Traditional Chinese medicine composition for treating ankylosing spondylitis and preparation method thereof

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating ankylosing spondylitis and a preparation method thereof. The traditional Chinese medicine is prepared from the following raw materials: 6-18 g of fructus psoraleae, 6-20 g of herba epimedii, 3-15 g of radix aconiti lateralis preparata, 6-20 g of rhizoma drynariae, 9-18 g of radix achyranthis bidentatae, 12-24 g of dipsacus root, 6-12 g of radix clematidis, 10-30 g of garden balsam stem, 10-30 g of lycopodium clavatum, 9-15 g of radix paeoniae rubra, 6-12 g of native copper, 3-9 g of Chinese polyphaga, 6-12 g of roasted rhubarb, 6-15 g of notopterygium root, 6-15 g of radix angelicae pubescentis, 6-12 g of radix saposhnikoviae, 3-9 g of ephedra, 9-15 g of radix paeoniae alba, 6- The traditional Chinese medicine composition is prepared by adding and reducing cassia twig, Chinese herbaceous peony and rhizoma anemarrhenae decoction which are Jingui to be a little, the inflammatory response, bone destruction and pain symptoms of ankylosing spondylitis are accurately improved through the synergistic effect of multiple target points, and meanwhile, the preparation process is standardized to ensure the stable medicine effect.

Description

Technical Field

[0001] The present invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for treating ankylosing spondylitis and a preparation method thereof. Background Art

[0002] Ankylosing spondylitis is a chronic autoimmune disease. The existing treatment plans mainly include non-steroidal anti-inflammatory drugs, immunosuppressants and biological agents. The treatment of traditional Chinese medicine is based on the principles of "tonifying the kidney and strengthening bones, dispelling wind and dampness, and activating blood circulation and dredging collaterals".

[0003] Problems and disadvantages of the prior art: The existing treatment plans have large side effects (such as gastrointestinal damage, liver and kidney toxicity) and high costs after long-term medication; the existing compound preparations of traditional Chinese medicine generally have problems such as complicated prescriptions, unstable curative effects, and lack of standardized processes. Summary of the Invention

[0004] The purpose of the present invention is to provide a traditional Chinese medicine composition for treating ankylosing spondylitis with a scientific prescription, definite curative effect and standardized preparation method, which can accurately improve the inflammatory reaction, bone destruction and pain symptoms of ankylosing spondylitis through multi-target synergistic effects, and at the same time standardize the preparation process to ensure stable drug efficacy.

[0005] To achieve the above purpose, the technical solution adopted by the present invention is: A traditional Chinese medicine composition for treating ankylosing spondylitis is made from the following raw materials: Psoralea corylifolia 6 - 18 g, Epimedium brevicornu 6 - 20 g, Radix Aconiti Lateralis Preparata 3 - 15 g, Drynaria fortunei 6 - 20 g, Achyranthes bidentata 9 - 18 g, Dipsacus asperoides 12 - 24 g, Clematis chinensis 6 - 12 g, Speranskia tuberculata 10 - 30 g, Lycopodium clavatum 10 - 30 g, Paeonia lactiflora 9 - 15 g, Pyritum (processed with vinegar) 6 - 12 g, Eupolyphaga seu Steleophaga 3 - 9 g, Rheum officinale (processed with honey) 6 - 12 g, Notopterygium incisum 6 - 15 g, Angelica pubescens 6 - 15 g, Saposhnikovia divaricata 6 - 12 g, Ephedra sinica 3 - 9 g, Paeonia lactiflora 9 - 15 g, Rehmannia glutinosa 6 - 18 g, Anemarrhena asphodeloides 6 - 15 g, Aucklandia lappa 6 - 12 g, Atractylodes lancea 3 - 9 g, Ramulus Cinnamomi 6 - 15 g, Aristolochia mollissima 6 - 15 g.

[0006] Further, the specific dosages are Psoralea corylifolia 12 g, Epimedium brevicornu 12 g, Radix Aconiti Lateralis Preparata 12 g, Paeonia lactiflora 12 g, Paeonia lactiflora 12 g, Aucklandia lappa 9 g, Atractylodes lancea 6 g, Achyranthes bidentata 12 g, Pyritum 9 g, Rehmannia glutinosa 9 g, Rheum officinale (processed with honey) 9 g, Drynaria fortunei 15 g, Anemarrhena asphodeloides 9 g, Eupolyphaga seu Steleophaga 9 g, Clematis chinensis 9 g, Speranskia tuberculata 20 g, Dipsacus asperoides 18 g, Saposhnikovia divaricata 9 g, Ramulus Cinnamomi 12 g, Notopterygium incisum 9 g, Angelica pubescens 9 g, Ephedra sinica 6 g, Lycopodium clavatum 20 g, Aristolochia mollissima 15 g.

[0007] Further, the Radix Aconiti Lateralis Preparata and Ephedra sinica need to be detoxified before use; the Pyritum is used after being processed with vinegar to remove dregs.

[0008] Another object of the present invention is to provide a method for preparing a Chinese medicine composition for treating ankylosing spondylitis, comprising the following steps: S1. After the natural copper is calcined red, it is immersed in rice vinegar to quench the crisp, and the impurities are removed and ground into powder for later use; the preparation of aconite and ephedra is prepared according to the "Chinese Pharmacopoeia" processing specification for detoxification; S2. Mix all the raw materials and boil them in water to make a decoction; or dry all the raw materials and mix them and grind them to a particle size of ≤200 μm, then pass them through a 50-mesh sieve and fill them into capsules.

[0009] Therapeutic mechanism: This prescription is modified from Guizhi Shaoyao Zhimu Decoction in Synopsis of the Golden Chamber; the main drugs (Psoralea corylifolia, Epimedium, and Aconite) are warm in nature, enter the kidney meridian, warm and tonify kidney yang, strengthen tendons and bones. The auxiliary drugs (Achyranthes bidentata, Rhizoma Dioscoreae, and Rhizoma Drynariae) enter the liver and kidney meridians, tonify the liver and kidney, strengthen the waist and knees, and inhibit bone destruction. The auxiliary drugs (Red Peony Root, Eupolyphaga Sinensis, and Natural Copper) are red peony root, Eupolyphaga Sinensis, and Natural Copper, which can promote blood circulation and remove blood stasis, dredge the meridians and relieve pain; Radix Penicilliae and Herba Lycopodii can dispel wind and dampness. The harmonizing drugs (White Peony Root, Radix Rehmanniae, and Rhizoma Anemarrhenae) are cool in nature, nourish yin and clear heat, balance the warm and dry properties, and reduce side effects.

[0010] The effect of the combination of main drugs The main drug plays a major therapeutic role for the main disease or main symptom, and is an indispensable core part of the prescription. In this prescription, the four herbs of Psoralea corylifolia, Epimedium, Prepared Aconite, and Drynaria fortunei work together to nourish the kidney and replenish essence, warm yang and dispel cold, which is the key to the treatment of the "kidney deficiency and governor cold" pathogenesis of ankylosing spondylitis. Psoralea corylifolia and Epimedium: Both have the effect of nourishing kidney yang and strengthening tendons and bones. Psoralea corylifolia focuses on nourishing the kidney and supporting yang, and is a basic drug for the root of kidney deficiency; Epimedium can not only nourish kidney yang and strengthen tendons and bones, but also has a positive effect on improving osteoporosis. The combination of the two drugs enhances the power of nourishing kidney yang and strengthening tendons and bones, fundamentally improving the patient's bone problems caused by kidney deficiency, and laying the foundation for the treatment of the disease. Prepared Aconite and other monarch drugs: Prepared Aconite warms the kidney and dispels cold, clears the twelve meridians, and can effectively relieve the typical symptom of "kidney deficiency and governor cold" in the spine, which is cold pain. It works with Psoralea corylifolia and Epimedium to strengthen the kidney yang while strengthening the ability to dispel cold and dredge the meridians, allowing the yang energy to reach the meridians throughout the body and improve the cold symptoms in the patient's body. Drynaria nourishes the kidney and strengthens bones, promotes bone repair and inhibits bone destruction. It works with the other three main herbs to comprehensively act on the kidneys and bones, improve bone lesions caused by kidney deficiency from multiple angles, and jointly target the core pathogenesis of ankylosing spondylitis.

[0011] Compatibility of adjuvant drugs Assistant herbs assist the sovereign herb in enhancing the treatment of the primary disease or syndrome, or act on the secondary diseases or syndromes. In this formula, Achyranthes bidentata, Dipsacus asperoides, Clematis chinensis, Speranskia tuberculata, and Lycopodium clavatum target the pathogenesis of "wind-damp obstruction" and "static blood obstruction in collaterals", directly relieving the symptoms. Achyranthes bidentata and Dipsacus asperoides: Achyranthes bidentata guides the herbs downward, strengthens the waist and knees, promotes blood circulation and dredges the meridians, can lead all the herbs to the affected area, enhances the effect of the herbs on the waist and knee parts, and at the same time promotes blood circulation and improves the condition of static blood obstruction in collaterals. Dipsacus asperoides supplements the liver and kidney, strengthens the muscles and bones, and dispels wind-dampness concurrently. In combination with Achyranthes bidentata, it not only enhances the efficacy of supplementing the liver and kidney and strengthening the muscles and bones, but also jointly dispels the pathogenic factors of wind-dampness, enabling the liver and kidney to be supplemented, the muscles and bones to be strengthened, and the wind-dampness to be eliminated. Clematis chinensis, Speranskia tuberculata, and Lycopodium clavatum: Clematis chinensis dispels wind-dampness, dredges the meridians, and is good at relieving joint stiffness and pain; Speranskia tuberculata specializes in treating bone joint wind-dampness and can soften ligament adhesions; Lycopodium clavatum focuses on relaxing tendons and activating collaterals and improving joint mobility. These three herbs cooperate with each other, targeting various symptoms caused by wind-damp obstruction in joint collaterals from different aspects, comprehensively improving joint stiffness, pain, and limited movement, etc., and collaborating with Achyranthes bidentata and Dipsacus asperoides to jointly assist the sovereign herb and strengthen the treatment of the secondary syndromes of the disease.

[0012] The Compatibility Functions of Assistant Herbs There are three meanings of assistant herbs: one is the assistant herb, which assists the sovereign and ministerial herbs in enhancing the therapeutic effect, or directly treats the secondary concurrent syndromes; the second is the adjuvant herb, which is used to eliminate or alleviate the toxicity or strong nature of the sovereign and ministerial herbs; the third is the counter-adjuvant herb, that is, according to the needs of the disease condition, a herb with a nature opposite to that of the sovereign herb is used and can play a complementary role in the treatment. There are various assistant herbs in this formula, each playing different roles.

[0013] Assistant Herbs for Promoting Blood Circulation to Remove Blood Stasis and Harmonizing the Properties of Herbs Paeonia lactiflora Pall.: Clears heat and cools blood, disperses stasis and relieves pain. It can not only assist the sovereign and ministerial herbs in activating blood circulation and dredging collaterals, but also prevent the yang-warming herbs from generating heat and fire. When combined with Paeonia albiflora, one disperses and one astringes, harmonizing qi and blood, making the qi and blood circulation more smooth and peaceful.

[0014] Pyritum (quenched with vinegar): Disperses stasis and relieves pain, promotes fracture healing. It enhances the blood-activating effect of the formula, has a certain repair effect on bone injuries that may be caused by the disease, further strengthens the treatment of the pathogenesis of static blood obstruction in collaterals, and assists the sovereign and ministerial herbs to exert better therapeutic effects.

[0015] Eupolyphaga seu Steleophaga: Breaks blood stasis, dredges collaterals and relieves pain. As an insect herb, it is good at penetrating deep into the meridians and has a good curative effect on stubborn pain. In the formula, it targets the stubborn blood stasis pain in the disease condition and plays the role of assisting the sovereign and ministerial herbs to strengthen the treatment.

[0016] Rhubarb (processed with honey): Purgates heat and relieves constipation, promotes blood circulation to remove blood stasis. For patients with constipation symptoms, retaining this herb can expel the accumulated heat in the body through the purgative effect, and at the same time its effect of promoting blood circulation to remove blood stasis also helps to improve the blood stasis state and assists other herbs to play better therapeutic roles.

[0017] Assistant Herbs for Dispelling Wind and Cold and Harmonizing the Exterior and Interior Notopterygium incisum and Angelica pubescens: Notopterygium incisum is good at dispelling wind-dampness in the upper body, while Angelica pubescens is better at dispelling wind-dampness in the lower body. The combination of the two can comprehensively remove wind-dampness throughout the body. According to the specific condition of the patient, one of them can be retained, or both can be used together to enhance the effect of dispelling wind-dampness and assist the monarch and minister herbs in treating the symptoms of wind-dampness blocking the channels.

[0018] Saposhnikovia divaricata: It dispels wind and relieves the exterior, eliminates dampness and alleviates pain, and has a certain anti-inflammatory effect. In the formula, it can enhance the power of the whole formula in dispelling wind and dampness, and its anti-inflammatory effect helps to relieve the pain caused by inflammation, assisting the monarch and minister herbs to better exert their curative effects.

[0019] Ephedra: It induces sweating to dispel cold and promotes the flow of yang qi. When the cold symptoms are obvious, retaining this herb can strengthen the power of the formula in dispelling cold, enabling the yang qi to flow smoothly, and improving the cold symptoms of the patient together with other herbs, assisting the monarch herb in warming yang and dispelling cold.

[0020] Compatibility effects of harmonizing herbs Harmonizing herbs mainly harmonize various herbs, enabling each herb in the formula to better exert its synergistic effect. Paeonia lactiflora, Rehmannia glutinosa, and Anemarrhena asphodeloides together play the role of nourishing yin and blood and balancing the warm and dry nature of herbs such as Aconiti Lateralis Radix Praeparata and Ramulus Cinnamomi.

[0021] Paeonia lactiflora: It has the effects of nourishing blood and astringing yin, and soothing the liver to relieve pain. In the formula, it can not only assist Rehmannia glutinosa and Anemarrhena asphodeloides in nourishing yin and blood, but also restrict the warm and dry nature of herbs such as Aconiti Lateralis Radix Praeparata and Ramulus Cinnamomi, making the property of the whole formula more moderate and avoiding excessive injury to yin by warm and dry herbs.

[0022] Rehmannia glutinosa: It nourishes yin and replenishes blood, and replenishes essence and marrow. It can nourish the yin of the liver and kidney, supplement the body's yin fluid, cooperate with Paeonia lactiflora and Anemarrhena asphodeloides to enhance the power of nourishing yin, and at the same time balance the dryness and fierceness of the yang-warming herbs in the formula, enabling yin and yang to coordinate with each other and making the formula achieve a better therapeutic effect.

[0023] Anemarrhena asphodeloides: It clears heat and purges fire, nourishes yin and moistens dryness. Its cooperation with Paeonia lactiflora and Rehmannia glutinosa can not only clear heat to prevent the yang-warming herbs from turning into heat and injuring yin, but also nourish yin and moisten dryness, further restricting the side effects of warm and dry herbs such as Aconiti Lateralis Radix Praeparata and Ramulus Cinnamomi, enabling the formula to maintain the balance of yin and yang while warming yang and dispelling cold, dispelling wind and dampness, and promoting blood circulation to remove stasis, and reducing the adverse reactions of the herbs.

[0024] Compatibility effects of secondary herbs These herbs can be appropriately added or subtracted according to the specific symptoms of the patient, and play an auxiliary therapeutic role in specific situations.

[0025] Saussurea costus: It promotes qi circulation to relieve pain. When the patient has obvious qi stagnation pain, adding this herb can promote qi movement, relieve the pain caused by qi stagnation, and enhance the therapeutic effect of the formula on pain symptoms.

[0026] Atractylodes: Drying dampness and strengthening the spleen. For patients with spleen deficiency and dampness, retaining Atractylodes can enhance the spleen and stomach transportation and transformation functions, remove dampness from the body, improve related symptoms caused by spleen deficiency and dampness, and assist the prescription to better exert the overall therapeutic effect.

[0027] Dried cinnamon twig: warms and unclogs the meridians. When the symptoms of cold stagnation and blood stasis are prominent, adding dried cinnamon twig can enhance the effect of warming and unblocking the blood vessels, promote blood circulation, improve the symptoms such as pain and limb numbness caused by cold stagnation and blood stasis, and synergize with other drugs to treat the disease.

[0028] Xungufeng: dispels rheumatism and relieves pain. Since its functions have been covered by Tougucao and Shenjincao, it can be used according to the actual symptoms. When Tougucao and Shenjincao can fully play their roles, Xungufeng can be removed to simplify the prescription.

[0029] The above-mentioned types of drugs are compatible and synergistic with each other, and work together to exert therapeutic effects on the complex pathogenesis and diverse symptoms of ankylosing spondylitis, achieving the best therapeutic effect overall.

[0030] The properties, meridians, effects and medical records of each herb: Psoralea corylifolia: Nature and flavor and meridians entered: pungent, bitter, warm; enters the kidney and spleen meridians.

[0031] Function: Warms the kidney and assists yang, consolidates semen and reduces urination, warms the spleen and stops diarrhea, and replenishes qi and relieves asthma. It is used for kidney yang deficiency, asthma and cough due to deficiency-cold, and cold pain in the waist and knees.

[0032] Medical records: "Compendium of Materia Medica" says that it "benefit the kidney qi and strengthen the primordial yang" and is often used for symptoms such as kidney deficiency, low back pain, and early morning diarrhea.

[0033] Epimedium: Nature and flavor and meridians entered: pungent, sweet, warm; enters the liver and kidney meridians.

[0034] Function: Nourishes kidney yang, strengthens tendons and bones, and eliminates rheumatism; mainly used to treat kidney yang deficiency and rheumatic pain.

[0035] Medical records: "Shennong's Herbal Classic" lists it as a medium-grade product, saying that it "treats impotence, paralysis, and pain in the penis."

[0036] Prepared Aconite root: Nature and flavor and meridians entered: pungent, sweet, very hot; enters the heart, kidney and spleen meridians.

[0037] Function: restore yang, spur fire and aid yang, dispel cold and relieve pain; used for yang loss, collapse, cold and dampness arthralgia.

[0038] Medical books record: In "Treatise on Febrile Diseases", Sini Decoction and Fuzi Decoction both use Fuzi as the main medicine.

[0039] Drynaria fortunei: Nature and flavor and meridians: bitter, warm; enters the liver and kidney meridians.

[0040] Function: Nourishes the kidney and strengthens bones, heals injuries and relieves pain; mainly used to treat kidney deficiency, low back pain, and traumatic injuries.

[0041] Medical records state: "Yaoxing Lun" records that it "treats poisonous qi in the bones and pain due to wind and blood".

[0042] Achyranthes bidentata: Nature, flavor, and meridian tropism: Bitter, sweet, sour, neutral; attributing to the liver and kidney meridians.

[0043] Functions: Promoting blood circulation to remove blood stasis, tonifying the liver and kidneys, strengthening the bones and muscles; used for soreness and weakness in the waist and knees, amenorrhea, and mass in the abdomen.

[0044] Medical records state: "Compendium of Materia Medica" says that it "treats chronic malaria with fever and chills, and stranguria with hematuria".

[0045] Dipsacus asperoides: Nature, flavor, and meridian tropism: Bitter, pungent, slightly warm; attributing to the liver and kidney meridians.

[0046] Functions: Tonifying the liver and kidneys, strengthening the bones and muscles, mending fractures; used for soreness and weakness in the waist and knees, falls and injuries.

[0047] Medical records state: "Huayan Ben Cao" states that "the severed blood vessels cannot be mended without this, and the injured bones and muscles cannot be nourished without this".

[0048] Clematis chinensis: Nature, flavor, and meridian tropism: Pungent, salty, warm; attributing to the bladder meridian.

[0049] Functions: Expelling wind-dampness, dredging the meridians, relieving bone obstruction; mainly treating rheumatic arthralgia, numbness of limbs.

[0050] Medical records state: "Kaibao Bencao" records that it "treats various wind syndromes, promotes the circulation of qi in the five zang-organs, and removes cold stagnation in the abdomen".

[0051] Phryma leptostachya L. var. asiatica Hara: Nature, flavor, and meridian tropism: Pungent, warm; attributing to the liver and kidney meridians.

[0052] Functions: Expelling wind and dampness, relaxing muscles and tendons, promoting blood circulation to relieve pain; used for rheumatic arthralgia, swelling and pain from falls and injuries.

[0053] Medical records state: Commonly used in external washing prescriptions, such as treating rheumatic bone pain in "Zhengzong of Surgery".

[0054] Lycopodium clavatum L.: Nature, flavor, and meridian tropism: Slightly bitter, pungent, warm; attributing to the liver, spleen, and kidney meridians.

[0055] Functions: Expelling wind and dampness, relaxing muscles and tendons; mainly treating difficulty in flexion and extension of joints, and muscle contracture.

[0056] Medical records state: "Compendium of Materia Medica": "Lycopodium clavatum L. expels wind and dampness, relaxes muscles and tendons, and treats rheumatic arthralgia." Paeonia lactiflora Pall.: Nature, flavor, and meridian tropism: Bitter, slightly cold; attributing to the liver meridian.

[0057] Functions: Clearing heat and cooling blood, promoting blood circulation to remove stasis and relieve pain; used for epidemic febrile disease with maculae, hematemesis and epistaxis due to blood heat.

[0058] Medical records state: Listed in the middle grade in "Shennong Ben Cao Jing", mainly treating "abdominal pain due to pathogenic qi, removing blood stasis obstruction".

[0059] Pyritum (quenched with vinegar): Nature, flavor, and meridian tropism: Pungent, neutral; attributing to the liver meridian.

[0060] Function: Disperse stasis and relieve pain, reconnect fractured bones and heal injuries; used for traumatic injuries and swelling pain due to fractures.

[0061] Recorded in medical books: Often combined with frankincense and myrrh, seen in the "Golden Mirror of Medicine" in the "Jiegu Zijin Dan".

[0062] Eupolyphaga seu Steleophaga: Nature, flavor and meridian tropism: salty, cold; belongs to the Liver Meridian.

[0063] Function: Break blood stasis, remove stasis, reconnect tendons and bones; mainly treats traumatic injuries and tendon and bone fractures.

[0064] Recorded in medical books: "Compendium of Materia Medica" states that it "has miraculous effects in treating traumatic injuries and reconnecting tendons and bones".

[0065] Fried Rheum officinale (Rheum palmatum): Nature, flavor and meridian tropism: bitter, cold; belongs to the Spleen, Stomach, Large Intestine, Liver and Pericardium Meridians.

[0066] Function: Induce purgation to attack accumulation, clear heat and purge fire, cool blood and detoxify; after being processed with wine, the power of promoting blood circulation to remove stasis is enhanced.

[0067] Recorded in medical books: In "Treatise on Febrile Diseases", Rheum officinale in Taohuachengqi Decoction is used to remove stasis and heat.

[0068] Notopterygium incisum: Nature, flavor and meridian tropism: pungent, bitter, warm; belongs to the Bladder and Kidney Meridians.

[0069] Function: Induce sweating to dispel cold, expel wind and dampness, relieve pain; used for wind-cold-damp arthralgia and pain in the shoulders and back.

[0070] Recorded in medical books: "Compendium of Materia Medica Comments" calls it "the essential herb for treating wind-dampness in the Taiyang Meridian".

[0071] Angelica pubescens: Nature, flavor and meridian tropism: pungent, bitter, slightly warm; belongs to the Kidney and Bladder Meridians.

[0072] Function: Expel wind and dampness, dredge collaterals and relieve pain; mainly treats wind-cold-damp arthralgia and pain in the waist and knees.

[0073] Recorded in medical books: "Justice of Materia Medica" states that it "promotes the flow of all meridians and harmonizes the collaterals".

[0074] Saposhnikovia divaricata: Nature, flavor and meridian tropism: pungent, sweet, slightly warm; belongs to the Bladder, Liver and Spleen Meridians.

[0075] Function: Expel wind and relieve the exterior, overcome dampness and relieve pain; used for exterior syndrome caused by exogenous pathogens and wind-damp arthralgia.

[0076] Recorded in medical books: Listed as a superior-grade herb in "Shennong Ben Cao Jing", mainly treating "severe headache due to wind".

[0077] Ephedra sinica: Nature, flavor and meridian tropism: pungent, slightly bitter, warm; belongs to the Lung and Bladder Meridians.

[0078] Function: Induce sweating to relieve the exterior, promote the dispersing function of the lung and relieve asthma, promote diuresis and reduce swelling; used for wind-cold exterior syndrome with no sweating.

[0079] Medical records state: In "Treatise on Febrile and Miscellaneous Diseases", Mahuang Decoction is a representative formula for inducing sweating and relieving exterior syndrome.

[0080] White Peony Root: Nature, flavor, and meridian tropism: Bitter, sour, slightly cold; attributing to the liver and spleen meridians.

[0081] Functions: Nourishing blood and regulating menstruation, astringing yin and stopping sweating, soothing the liver and relieving pain; used for sallow complexion due to blood deficiency, spontaneous sweating and night sweating.

[0082] Medical records state: "Compendium of Materia Medica" states that it "benefits the spleen, purges the liver, and soothes the middle energizer".

[0083] Prepared Rehmannia Root: Nature, flavor, and meridian tropism: Sweet, slightly warm; attributing to the liver and kidney meridians.

[0084] Functions: Tonifying blood and nourishing yin, replenishing essence and marrow; used for sallow complexion due to blood deficiency, yin deficiency of the liver and kidney.

[0085] Medical records state: "Complete Works of Jingyue" states that it "greatly tonifies blood decline and nourishes kidney water".

[0086] Anemarrhena Rhizome: Nature, flavor, and meridian tropism: Bitter, sweet, cold; attributing to the lung, stomach, and kidney meridians.

[0087] Functions: Clearing heat and purging fire, nourishing yin and moistening dryness; used for feverish thirst, cough due to lung heat.

[0088] Medical records state: Listed in the middle grade in "Shennong's Classic of Materia Medica", mainly treating "consumptive thirst and heat in the middle energizer".

[0089] Costus Root: Nature, flavor, and meridian tropism: Pungent, bitter, warm; attributing to the spleen, stomach, large intestine, and triple energizer meridians.

[0090] Functions: Promoting qi circulation to relieve pain, strengthening the spleen and promoting digestion; used for epigastric and abdominal distension pain, tenesmus.

[0091] Medical records state: "Compendium of Materia Medica" states that it "is a medicine for the qi aspect of the triple energizer and can regulate qi in all directions".

[0092] Atractylodes Rhizome: Nature, flavor, and meridian tropism: Pungent, bitter, warm; attributing to the spleen, stomach, and liver meridians.

[0093] Functions: Drying dampness and strengthening the spleen, expelling wind and cold; used for dampness obstructing the middle energizer, rheumatic arthralgia pain.

[0094] Medical records state: "Compendium of Materia Medica" states that it "treats retention of damp phlegm, downward flow of spleen dampness resulting in turbid discharge".

[0095] Dry Ramulus Cinnamomi: Nature, flavor, and meridian tropism: Pungent, sweet, warm; attributing to the heart, lung, and bladder meridians.

[0096] Functions: Inducing sweating and releasing the muscles, warming and dredging the meridians, assisting yang to transform qi; used for exterior syndrome of wind-cold, cold congealing and blood stasis.

[0097] Medical records state: In "Treatise on Febrile and Miscellaneous Diseases", Cinnamon Twig Decoction is a representative formula for regulating nutrient qi and defensive qi.

[0098] Mogwort Herb: Nature, flavor, and meridian tropism: Pungent, bitter, flat; attributing to the liver meridian.

[0099] Function: Dispelling wind-dampness, dredging collaterals and relieving pain; used for wind-damp arthralgia and limb numbness.

[0100] Recorded in medical books: "New Reference of Decoction Pieces" records that it "dispels wind-bi, dredges collaterals and treats bone joint pain".

[0101] In the formula, the monarch drugs tonify the kidney and strengthen bones, warm yang and dredge Du meridian; specifically, Psoralea corylifolia: tonifying the kidney and assisting yang, strengthening tendons and bones, targeting the root of kidney deficiency; Epimedium brevicornum: warming the kidney yang, strengthening tendons and bones, improving osteoporosis; Prepared Radix Aconiti Lateralis Praeparata (decocted first): warming the kidney and dispelling cold, dredging the twelve meridians, relieving cold pain in the spine. Drynaria fortunei: tonifying the kidney and strengthening bones, promoting bone repair, inhibiting bone destruction; the four work together to tonify the kidney and replenish essence, warm yang and dispel cold, and are the core for treating the pathogenesis of "kidney deficiency and Du meridian cold" in ankylosing spondylitis; the ministerial drugs dispel wind-dampness, activate blood circulation and dredge collaterals; specifically, Achyranthes bidentata: guiding the drugs downward, strengthening the waist and knees, activating blood circulation and dredging menstruation; Dipsacus asperoides: tonifying the liver and kidney, strengthening tendons and bones, and dispelling wind-dampness; Clematis chinensis: dispelling wind-dampness, dredging collaterals, relieving joint stiffness and pain; Speranskia tuberculata: specializing in treating wind-dampness in bone joints, softening ligament adhesions; Lycopodium clavatum: relaxing tendons and activating collaterals, improving joint mobility; targeting the pathogenesis of "wind-damp obstruction" and "blood stasis blocking collaterals", directly relieving symptoms; Specific implementation method

[0102] Example 1 A traditional Chinese medicine composition for treating ankylosing spondylitis is composed of 24 traditional Chinese medicines including 12 g of Psoralea corylifolia, 12 g of Epimedium brevicornum, 12 g of Prepared Radix Aconiti Lateralis Praeparata (decocted first), 15 g of Drynaria fortunei, 12 g of Achyranthes bidentata, 18 g of Dipsacus asperoides, 9 g of Clematis chinensis, 20 g of Speranskia tuberculata, 20 g of Lycopodium clavatum, 12 g of Paeonia lactiflora, 9 g of Pyritum (quenched with vinegar and the residue removed), 9 g of Eupolyphaga seu Steleophaga, 9 g of Rhizoma Rhei Praeparatum, 9 g of Notopterygium incisum, 9 g of Angelica pubescens, 9 g of Saposhnikovia divaricata, 6 g of Ephedra sinica, 12 g of Paeonia lactiflora, 9 g of Rehmannia glutinosa, 9 g of Anemarrhena asphodeloides, 9 g of Aucklandia lappa, 6 g of Atractylodes lancea, 12 g of Ramulus Cinnamomi, 15 g of Aristolochia mollissima, etc.

[0103] A preparation method of a traditional Chinese medicine composition for treating ankylosing spondylitis includes the following steps: Step 1: Pretreatment. Pyritum is treated by quenching with vinegar (calcine Pyritum until it is red-hot, then immerse it in rice vinegar until it becomes brittle, remove impurities and grind it into powder for later use). Prepared Radix Aconiti Lateralis Praeparata and Ephedra sinica are treated to reduce toxicity according to the processing specifications of the Chinese Pharmacopoeia.

[0104] Step 2: Mixing and pulverizing. Dry all the raw materials and mix them, pulverize them to a particle size ≤ 200 μm, and pass through a 50-mesh sieve to obtain uniform fine powder.

[0105] Step 3: Preparation of the preparation. It can be made into a decoction or capsules according to clinical needs (note: the decoction does not need to be pulverized).

[0106] Preparation of the decoction: Weigh each medicinal material according to the ratio, add 7 times the amount of water and soak for 30 - 60 minutes, decoct once in the morning and once in the evening (1.5 hours for the first time and 1 hour for the second time), and concentrate to 1 g of crude drug per milliliter.

[0107] The preparation of the capsule involves filling powder into the capsule shell. Each capsule contains 0.5 g of crude drug and is taken 4 capsules each time, 3 times a day.

[0108] Application examples Clinical cases Statistical data: A total of 220 cases were treated, including 174 males and 46 females. Those under 40 years old accounted for 71%, and those over 60 years old accounted for 29%. Among them, 161 cases were cured, 23 cases showed marked improvement, and 21 cases were effective.

[0109] Evaluation criteria: Cured: Symptoms such as pain and stiffness in the lumbosacral region and peripheral joints completely disappeared, the spinal range of motion returned to normal, and the Schober test, "4" - word test, and pelvic compression test were all negative. Erythrocyte sedimentation rate (ESR) and C - reactive protein (CRP) returned to normal, and CT of the sacroiliac joint showed bone repair of the joint surface and improvement of the joint space.

[0110] Marked improvement: Symptoms such as pain and stiffness in the lumbosacral region and peripheral joints were significantly reduced, the spinal range of motion was significantly improved, and the Schober test, "4" - word test, and pelvic compression test were significantly improved compared with before treatment. ESR and CRP decreased significantly, and CT of the sacroiliac joint showed that the progression of bone destruction of the joint surface was controlled.

[0111] Effective: Symptoms such as pain and stiffness in the lumbosacral region and peripheral joints were somewhat relieved, the spinal range of motion was somewhat improved, and the Schober test, "4" - word test, and pelvic compression test were somewhat improved. ESR and CRP decreased somewhat, and CT of the sacroiliac joint showed that there was no obvious progression of bone destruction of the joint surface.

[0112] Ineffective: Those who did not meet the above criteria.

[0113] After 3 - course treatment, among 220 patients, 161 cases (73.18%) were cured, 23 cases (10.45%) showed marked improvement, 21 cases (9.55%) were effective, and 15 cases (6.82%) were ineffective. The total effective rate was 93.18%. In terms of age distribution, the effective rate of patients under 40 years old was 97.44% (152 / 156), and the effective rate of patients over 60 years old was 82.81% (53 / 64). The effective rate of patients under 40 years old was significantly higher than that of patients over 60 years old (P < 0.05). In terms of gender, the effective rate of male patients was 94.25% (164 / 174), and the effective rate of female patients was 89.13% (41 / 46). The effective rate of male patients was slightly higher than that of female patients, but the difference was not statistically significant (P > 0.05).

[0114] Specific cases Case 1: Ankylosing Spondylitis of Liver and Kidney Deficiency Syndrome Complicated with Cold-Dampness Blockage Syndrome Patient Information: Lin, male, 30 years old, a programmer. Permanent address: Shangqiu City, Henan Province, unmarried.

[0115] Date of First Diagnosis: March 5, 2023 Symptoms at First Diagnosis: The patient has felt dull pain in the lumbosacral region for nearly 8 months, which is aggravated in the early morning and after rest and relieved slightly after activity. There are also soreness and weakness in the waist and knees, accompanied by fatigue. The pain intensifies when exposed to cold and during rainy weather. There is numbness in both lower extremities from time to time, and the sleep quality at night is poor. The tongue is pale and plump, with tooth marks on the sides, the tongue coating is white and greasy, and the pulse is deep, thready and weak.

[0116] Physical Examination: The physiological curvature of the spine is straightened, and the range of motion is limited. When bending forward, the distance from the fingertips to the ground is 20 cm (normal is less than 10 cm), the backward extension angle is 10° (normal is greater than 30°), the left lateral bending angle is 15° (normal is greater than 20°), and the right lateral bending angle is 15° (normal is greater than 20°). The Schober test is positive (<4 cm), the "4" - word test is positive, and the pelvic compression test is positive. When performing the bilateral "4" - word test, the pain in the right buttock and groin is obvious, and the left side is slightly relieved. When performing the pelvic compression test, the pain in the lumbosacral region of the patient intensifies. Auxiliary Examinations: Erythrocyte sedimentation rate (ESR) is 50 mm / h (normal for men is 0 - 15 mm / h), C - reactive protein (CRP) is 30 mg / L (normal is <8 mg / L). The MRI of the sacroiliac joint shows that the surfaces of both sacroiliac joints are rough, and long T2 signal shadows can be seen in the joint space, indicating joint inflammation; small cystic long T1 and long T2 signal foci can be seen in the subchondral bone, considering bone erosion. The lumbar X - ray film shows that the edges of the lumbar vertebrae are blurred, and the intervertebral joint spaces of some vertebrae are narrowed.

[0117] Diagnosis: Traditional Chinese Medicine Diagnosis: Bi Syndrome (Liver and Kidney Deficiency Syndrome Complicated with Cold - Dampness Blockage Syndrome); Western Medicine Diagnosis: Ankylosing Spondylitis.

[0118] Medication at First Diagnosis: Bugu Qiangji Decoction.

[0119] Prescription: Psoralea corylifolia 12 g, Epimedium brevicornu 12 g, Prepared Aconite Root (decocted first) 12 g, Red Peony Root 12 g, White Peony Root 12 g, Aucklandia lappa 9 g, Atractylodes lancea 6 g, Achyranthes bidentata 12 g, Pyritum (quenched with vinegar and removed the dregs) 9 g, Rehmannia glutinosa 9 g, Rhubarb processed with honey 9 g, Drynaria fortunei 15 g, Anemarrhena asphodeloides 9 g, Eupolyphaga sinensis 9 g, Clematis chinensis 9 g, Speranskia tuberculata 20 g, Dipsacus asperoides 18 g, Saposhnikovia divaricata 9 g, Ramulus Cinnamomi 12 g, Notopterygium incisum 9 g, Angelica pubescens 9 g, Ephedra sinica 6 g, Lycopodium clavatum 20 g, Aristolochia mollissima 15 g. 7 doses, 1 dose per day, decocted in water and taken warm in the morning and evening.

[0120] Therapeutic effect and follow-up visit: First follow-up visit (March 13, 2023): The patient reported that the pain in the lumbosacral region was slightly relieved, but still felt fatigued, weak in the waist and knees. The roasted Rhubarb was removed from the original prescription, and 15g of Taxillus chinensis was added to enhance the power of tonifying the liver and kidney and strengthening the bones and muscles. Continue to take the medicine for 14 doses. Second follow-up visit (March 28, 2023): The patient's lumbosacral pain was significantly relieved, the numbness in the lower limbs was reduced, and the sleep quality was improved, but still felt that the symptoms worsened when encountering cold. 3g of Asarum was added to the original prescription to enhance the efficacy of dispelling cold and relieving pain. Continue to take the medicine for 14 doses. Third follow-up visit (April 15, 2023): The patient's symptoms were significantly improved, and there was only slight discomfort after fatigue. Keep the prescription and take the medicine for another 14 doses to consolidate the therapeutic effect. After the condition stabilized, switch to capsule form for regular use, 4 capsules each time, 3 times a day, taken with warm water. Therapeutic effect evaluation: After treatment, the patient's symptoms were significantly reduced, and the quality of life was significantly improved. Follow-up for 3 months, the condition was stable, and there was no obvious recurrence.

[0121] Case 2: Ankylosing spondylitis of the type of kidney-yang deficiency combined with blood stasis blocking collaterals Patient information: Guo, female, 38 years old, accountant. Permanent address: Shangqiu City, Henan Province, married.

[0122] Initial diagnosis date: May 10, 2023 Initial diagnosis symptoms: The patient had pain in the lumbosacral region for more than half a year. The pain was stabbing, fixed, the movement of the waist was limited, accompanied by fear of cold and cold limbs, and frequent urination at night. The tongue was dark, with ecchymosis, the coating was thin and white, and the pulse was deep and unsmooth.

[0123] Physical examination: The movement of the spine was significantly limited. When the lumbar spine was flexed forward, the distance between the chest and the thigh was 15cm (should be close normally), when extended backward, the pain was aggravated and the angle was only 5° (should be greater than 30° normally), when laterally flexed, both sides were less than 10° (should be greater than 20° normally). Schober test was positive (<4cm), "4" word test was positive, and pelvic compression test was positive. During the "4" word test, the patient had severe pain in both hip joints and could not complete the standard movement. During the pelvic compression test, the patient had a painful expression and unbearable pain in the lumbosacral region. Auxiliary examination: Erythrocyte sedimentation rate (ESR) 48mm / h, C-reactive protein (CRP) 25mg / L. Plain CT scan of the sacroiliac joint showed that the joint surfaces of both sacroiliac joints were uneven, the joint spaces were of different widths, and bone hyperplasia and moth-eaten bone destruction could be seen in some areas. Pelvic X-ray showed increased bone density of both sacroiliac joints and blurred joint spaces.

[0124] Diagnosis: Traditional Chinese medicine diagnosis: Bi syndrome (type of kidney-yang deficiency combined with blood stasis blocking collaterals); Western medicine diagnosis: Ankylosing spondylitis.

[0125] Medication at initial diagnosis: Bushen Qiangji Decoction.

[0126] Prescription: Psoralea corylifolia 12g, Epimedium brevicornu 12g, Prepared Aconite Root (decocted first) 12g, Red Peony Root 12g, White Peony Root 12g, Aucklandia lappa 9g, Atractylodes lancea 6g, Achyranthes bidentata 12g, Pyritum (quenched with vinegar and the dregs removed) 9g, Rehmannia glutinosa 9g, Rhubarb 9g, Drynaria fortunei 15g, Anemarrhena asphodeloides 9g, Eupolyphaga sinensis 9g, Clematis chinensis 9g, Speranskia tuberculata 20g, Dipsacus asperoides 18g, Saposhnikovia divaricata 9g, Ramulus Cinnamomi 12g, Notopterygium incisum 9g, Angelica pubescens 9g, Ephedra sinica 6g, Lycopodium clavatum 20g, Aristolochia mollissima 15g. 14 doses, 1 dose per day, decocted in water and taken warm in two divided doses.

[0127] Therapeutic effect and follow-up visit: First follow-up visit (May 26, 2023): The pain in the lumbosacral region of the patient was relieved, but there was still a stabbing pain, and the frequency of nocturia decreased. Remove Atractylodes lancea from the original prescription and add 9g of Persica vulgaris to enhance the power of promoting blood circulation and removing stasis. Continue to take 14 doses. Second follow-up visit (June 19, 2023): The pain of the patient was further relieved, the range of motion of the waist increased, and the symptoms of fear of cold were alleviated. Remove Ephedra sinica from the original prescription and add 12g of Morinda officinalis to enhance the effect of tonifying kidney yang. Continue to take 28 doses. Third follow-up visit (July 28, 2023): The symptoms of the patient were significantly improved, and there was only slight discomfort after sitting for a long time. Keep the prescription and make it into capsules for regular use, 4 capsules each time, 3 times a day, taken with warm water.

[0128] Therapeutic effect evaluation: After treatment, the symptoms of the patient were effectively controlled and the activity ability was restored. Follow-up for 3 months, the condition was stable.

[0129] Case 3: Ankylosing spondylitis of qi and blood deficiency combined with wind-damp obstruction type Patient information: Xu, male, 35 years old, a courier. Permanent address: Shangqiu City, Henan Province, married.

[0130] Initial diagnosis date: July 15, 2023 Initial diagnosis symptoms: The patient had pain in the lumbosacral region and bilateral hip joints for 1 year. The pain was migratory, accompanied by limb numbness, weakness, pale complexion, shortness of breath and reluctance to talk. The tongue was pale, the coating was thin and white, and the pulse was thready and weak.

[0131] Physical examination: The range of motion of the spine was poor. When bending forward, external force was needed, and the distance between the fingertips and the ground was 30cm. It was almost impossible to complete backward extension, and the lateral flexion angles on both sides were less than 5°. Schober test was positive (<4cm), "4" - word test was positive, and pelvic compression test was positive. During the "4" - word test, pain occurred alternately in the bilateral hip joints, with the right side being more severe. During the pelvic compression test, the patient felt pain in the lumbosacral region and bilateral hip joints. Auxiliary examination: Erythrocyte sedimentation rate (ESR) was 42mm / h, C-reactive protein (CRP) was 22mg / L. Sacroiliac joint angiography showed irregular stenosis of the bilateral sacroiliac joint spaces, rough and uneven joint surfaces, and uneven distribution of the contrast agent. Blood routine examination showed hemoglobin of 100g / L (normal for men is 120 - 160g / L), indicating anemia.

[0132] Diagnosis: Traditional Chinese Medicine diagnosis: Bi syndrome (type of qi and blood deficiency complicated with wind-damp obstruction); Western medicine diagnosis: Ankylosing spondylitis.

[0133] Medication at the first visit: Bugu Qiangji Decoction.

[0134] Prescription: Psoralea corylifolia 12g, Epimedium brevicornu 12g, Prepared Aconite Root (decocted first) 12g, Red Peony Root 12g, White Peony Root 12g, Aucklandia lappa 9g, Atractylodes lancea 6g, Achyranthes bidentata 12g, Pyritum (quenched with vinegar and the residue removed) 9g, Rehmannia glutinosa 9g, Rhubarb (processed) 9g, Drynaria fortunei 15g, Anemarrhena asphodeloides 9g, Eupolyphaga sinensis 9g, Clematis chinensis 9g, Speranskia tuberculata 20g, Dipsacus asperoides 18g, Saposhnikovia divaricata 9g, Ramulus Cinnamomi 12g, Notopterygium incisum 9g, Angelica pubescens 9g, Ephedra sinica 6g, Lycopodium clavatum 20g, Aristolochia mollissima 15g, Astragalus membranaceus 30g, Angelica sinensis 12g. 7 doses, 1 dose per day, decocted in water and taken warm in two divided doses.

[0135] Therapeutic effect and follow-up visit: First follow-up visit (July 23, 2023): The patient's pain was relieved, but still felt fatigued. Remove Rhubarb (processed) from the original prescription, add Pseudostellaria heterophylla 15g to enhance the qi-tonifying power. Continue to take for 14 doses. Second follow-up visit (August 9, 2023): The patient's limb numbness was reduced, the complexion gradually became rosy, but there was still slight joint pain. Remove Ephedra sinica and Atractylodes lancea from the original prescription, add Gentiana macrophylla 9g to enhance the power of expelling wind and dampness. Continue to take for 14 doses. Third follow-up visit (August 26, 2023): The patient's symptoms were significantly improved and physical strength was restored. Keep the prescription and continue to take for 1 month to consolidate the therapeutic effect. After the condition stabilized, change to capsule form of the same prescription for regular use, 4 capsules each time, 3 times a day, taken with warm water.

[0136] Therapeutic effect evaluation: After treatment, the patient's symptoms were relieved, and life and work were basically not affected. Follow-up for 6 months, the condition was stable.

[0137] Case 4: Ankylosing spondylitis of the type of cold-damp stagnation complicated with liver-kidney deficiency Patient information: Deng, female, 26 years old, kindergarten teacher. Permanent address: Shangqiu City, Henan Province, unmarried.

[0138] Date of first visit: September 20, 2023 Symptoms at the first visit: The patient had lumbosacral pain accompanied by stiffness for 3 months. The stiffness was particularly obvious in the morning and could only be relieved after more than half an hour of activity. The pain was aggravated by cold and relieved by warmth, accompanied by dizziness, tinnitus, and soreness and weakness of the waist and knees. The tongue was pale, the tongue coating was white, and the pulse was deep and slow.

[0139] Physical examination: The spine is rigid, with severely limited mobility. When bending forward, the angle between the body and the thigh is 45° (normally close to 0°), the backward extension angle is about 8° (normally greater than 30°), and the range of lateral flexion on both the left and right is less than 12° (normally greater than 20°). The Schober test is positive (<4 cm), the "4" - word test is positive, and the pelvic compression test is positive. During the "4" - word test, the patient has obvious pain in the right buttock and the inner thigh. During the pelvic compression test, the pain in the lumbosacral region of the patient is aggravated, and the expression is painful. Auxiliary examinations: Erythrocyte sedimentation rate (ESR) is 55 mm / h, and C - reactive protein (CRP) is 32 mg / L. Ultrasound of the sacroiliac joint shows thickening of the synovium of both sacroiliac joints, effusion can be seen in the joint cavity, the echo of the joint surface is uneven, and the echo is enhanced or weakened in some areas. Dual - energy X - ray bone density detection suggests reduced bone mass in the lumbar spine and pelvis.

[0140] Diagnosis: Traditional Chinese medicine diagnosis: Bi syndrome (type of cold - damp stagnation combined with liver - kidney deficiency); Western medicine diagnosis: Ankylosing spondylitis.

[0141] Medication at the first visit: Bugu Qiangji Decoction.

[0142] Prescription: Psoralea corylifolia 12 g, Epimedium brevicornu 12 g, Prepared Aconite Root (decocted first) 12 g, Red Peony Root 12 g, White Peony Root 12 g, Aucklandia lappa 9 g, Atractylodes lancea 6 g, Achyranthes bidentata 12 g, Pyritum (quenched with vinegar and filtered) 9 g, Rehmannia glutinosa 9 g, Rhubarb (processed) 9 g, Drynaria fortunei 15 g, Anemarrhena asphodeloides 9 g, Eupolyphaga sinensis 9 g, Clematis chinensis 9 g, Speranskia tuberculata 20 g, Dipsacus asperoides 18 g, Saposhnikovia divaricata 9 g, Ramulus Cinnamomi 12 g, Notopterygium incisum 9 g, Angelica pubescens 9 g, Ephedra sinica 6 g, Lycopodium clavatum 20 g, Aristolochia mollissima 15 g. 14 doses, 1 dose per day, decocted in water and taken warm in two divided doses.

[0143] Efficacy and follow - up visit: First follow - up visit (October 4, 2023): The pain in the lumbosacral region of the patient is reduced, but the stiffness is not significantly improved. Remove Rhubarb (processed) from the original prescription and add Zaocys dhumnades 9 g to dispel wind and dredge collaterals to improve the stiffness symptom. Continue to take for 21 doses.

[0144] Second follow - up visit (October 28, 2023): The patient's stiffness is reduced, the symptoms of dizziness and tinnitus are slightly relieved, but still feels weak in the waist and knees. Add Eucommia ulmoides 15 g to the original prescription to enhance the effect of tonifying the liver and kidney and strengthening the waist and knees. Continue to take for 28 doses. Third follow - up visit (December 2, 2023): The patient's symptoms are significantly reduced and can move freely. Keep the original prescription and take for another 28 doses to consolidate the curative effect. After the condition is stable, switch to capsule form for regular use, 4 capsules each time, 3 times a day, taken with warm water.

[0145] Efficacy evaluation: After treatment, the patient's symptoms are significantly improved and daily activities are not restricted. Follow - up for 6 months, the condition is stable.

[0146] Case 5: Ankylosing spondylitis of phlegm - stasis obstruction combined with kidney - yang deficiency type Patient Information: Huang, male, 52 years old, a driver. Permanent address: Shangqiu City, Henan Province, married.

[0147] Date of First Diagnosis: November 10, 2023 Symptoms at First Diagnosis: The patient has had pain in the lumbosacral region accompanied by limited mobility for 2 years. The pain is like a stabbing by a cone, fixed at the painful area. The joints are swollen and deformed, the skin is rough and scaly, accompanied by fear of cold and cold limbs, and fatigue. The tongue is purple and dark, with ecchymosis, the tongue coating is white and greasy, and the pulse is stringy and unsmooth.

[0148] Physical Examination: The spine shows a mild kyphotic deformity, with severely limited mobility. When bending forward, the distance between the chest and the thigh is 25 cm. Extension and lateral flexion are basically impossible to complete. The Schober test is positive (<4 cm), the "4" - word test is positive, and the pelvic compression test is positive. During the "4" - word test, both hip joints are severely painful, and joint movement is significantly limited. During the pelvic compression test, the patient has severe pain in the lumbosacral region, which is unbearable. Auxiliary Examinations: Erythrocyte sedimentation rate (ESR) is 58 mm / h, C - reactive protein (CRP) is 35 mg / L. Enhanced MRI scan of the sacroiliac joints shows severe damage to the bilateral sacroiliac joint surfaces, obvious narrowing of the joint space, thickening of the soft tissues around the joints, and obvious enhancement, indicating active inflammation. Serum immunoglobulin examination shows a slight increase in IgA and IgG.

[0149] Diagnosis: Traditional Chinese Medicine Diagnosis: Bi - syndrome (phlegm - stasis obstruction combined with kidney - yang deficiency type); Western Medicine Diagnosis: Ankylosing Spondylitis.

[0150] Medication at First Diagnosis: Bugu Qiangji Decoction.

[0151] Prescription: Psoralea corylifolia 12 g, Epimedium brevicornu 12 g, Prepared Aconite Root (decocted first) 12 g, Red Peony Root 12 g, White Peony Root 12 g, Aucklandia lappa 9 g, Atractylodes lancea 6 g, Achyranthes bidentata 12 g, Pyritum (quenched with vinegar and filtered) 9 g, Rehmannia glutinosa 9 g, Rhubarb (processed) 9 g, Drynaria fortunei 15 g, Anemarrhena asphodeloides 9 g, Eupolyphaga seu Steleophaga 9 g, Clematis chinensis 9 g, Herba Speranskiae tuberculatae 20 g, Dipsacus asperoides 18 g, Saposhnikovia divaricata 9 g, Ramulus Cinnamomi 12 g, Notopterygium incisum 9 g, Angelica pubescens 9 g, Ephedra sinica 6 g, Lycopodium clavatum 20 g, Aristolochia mollissima 15 g. 28 doses, 1 dose per day, decocted in water and taken warm in two divided doses.

[0152] Therapeutic Effect and Follow - up Visits: First Follow - up Visit (December 8, 2023): The patient's pain was slightly relieved, but the joint swelling was still obvious. Remove Atractylodes lancea from the original prescription, add Squama Manis 6 g (substitute) to enhance the power of resolving phlegm and removing stasis, and dredging collaterals and dissipating nodules. Continue to take 28 doses. Second Follow - up Visit (January 10, 2024): The patient's joint pain was reduced, the swelling was somewhat relieved, and the fear - of - cold symptom was alleviated. Remove Ephedra sinica from the original prescription, add Cuscuta chinensis 15 g to enhance the effect of tonifying kidney - yang. Continue to take 28 doses. Third Follow - up Visit (February 18, 2024): The patient's symptoms were significantly improved, and the joint mobility increased. Keep the original prescription and take 14 more doses to consolidate the therapeutic effect, and then switch to capsule form for regular use, 4 capsules each time, 3 times a day, taken with warm water.

[0153] Efficacy evaluation: After systematic treatment, the patient's symptoms improved and joint function gradually recovered. After 6 months of follow-up, the condition was stable.

Claims

1. A Chinese medicine composition for treating ankylosing spondylitis, characterized in that: It is made from the following raw materials: 6-18g of Psoralea corylifolia, 6-20g of Epimedium, 3-15g of processed Aconite root, 6-20g of Drynaria fortunei, 9-18g of Achyranthes bidentata, 12-24g of Chuanduan, 6-12g of Clematidis, 10-30g of Radix Pennisetum, 10-30g of Herba Lycopodii, 9-15g of Red Peony Root, 6-12g of Natural Copper, 3-9g of Eupolyphaga Sinensis, 6-12g of Rhizoma Chuanxiong, 6-15g of Notopterygium, 6-15g of Angelica dahurica, 6-12g of Saposhnikovia divaricata, 3-9g of Ephedra sinica, 9-15g of White Peony Root, 6-18g of Rehmannia root, 6-15g of Anemarrhena asphodeloides, 6-12g of Radix Aucklandiae, 3-9g of Atractylodes, 6-15g of Dry Cinnamomum Cassiae, and 6-15g of Xungusifolia.

2. The Chinese medicine composition for treating ankylosing spondylitis according to claim 1, characterized in that: It is made from the following raw materials: 12g of Psoralea corylifolia, 12g of Epimedium, 12g of processed Aconite root, 12g of Red Peony Root, 12g of White Peony Root, 9g of Guangmuxiang, 6g of Atractylodes, 12g of Achyranthes bidentata, 9g of Natural Copper, 9g of Rehmannia Glutinosa, 9g of Roasted Chuanjun, 15g of Drynaria, 9g of Anemarrhena, 9g of Scolopendra subspinipes, 9g of Clematidis, 20g of Radix Penicillae, 18g of Chuanduan, 9g of Saposhnikovia divaricata, 12g of dried cinnamon twig, 9g of Notopterygium wilfordii, 9g of Angelica dahurica, 6g of Ephedra, 20g of Smilax glabra, and 15g of Xungufeng.

3. The Chinese medicine composition for treating ankylosing spondylitis according to any one of claims 1 or 2, characterized in that: The prepared aconite root and ephedra must be treated for toxicity reduction before use; the natural copper is treated with vinegar to remove the residue before use.

4. The method for preparing the Chinese medicine composition for treating ankylosing spondylitis according to claim 3, characterized in that: The following steps are involved: S1. After the natural copper is calcined red, it is immersed in rice vinegar to quench, and the impurities are removed and ground into powder for later use; the preparation of aconite and ephedra is treated according to the "Chinese Pharmacopoeia" processing specification for detoxification; S2. Mix all the raw materials and boil them in water to make a decoction; or dry all the raw materials and mix them and grind them to a particle size of ≤200 μm, then pass them through a 50-mesh sieve and fill them into capsules.