Sargentodoxa cuneata mouth wash and preparation method thereof

Abstract

The invention provides a silver fruit mouthwash and a preparation method thereof, and belongs to the technical field of biological medicines. By combining a plurality of medicines and adopting a specific preparation method, the obtained product can effectively improve bad breath and optimize comprehensive conditions of the oral cavity, so that the tongue and palate are moist, the coated tongue and debris are reduced, and the conditions of the mouth and the lip are improved; and gingival indexes of patients with partial inflammation are reduced. Most patients can well evaluate the taste, the smell and the overall effect. The honeysuckle fruit mouthwash provides a new choice for oral care, is of great significance in improving oral health, improving life quality, meeting market requirements and the like, and plays a positive role in promoting the development of the oral care industry.

Description

Technical Field

[0001] The present invention relates to the field of biological medicine technology, and particularly relates to a silver fruit mouthwash and a preparation method thereof. Background Art

[0002] In today's society, oral health has become one of the key health areas that people focus on. With the improvement of living standards, people's attention to oral care has increased day by day, and the market demand for oral care products has also been continuously expanding. As an important part of oral care products, mouthwashes have been widely used in daily life.

[0003] Oral malodor is a common oral problem. It not only affects an individual's social image but may also imply potential health hazards in the oral cavity or other parts of the body. The causes of oral malodor are relatively complex and mainly include poor oral hygiene, food residue retention, bacterial growth, and oral diseases (such as dental caries, periodontitis, etc.). Although traditional brushing can clean the oral cavity to a certain extent, its cleaning effect on the deep and hidden parts of the oral cavity is limited, and it is difficult to completely eliminate oral malodor.

[0004] In addition to oral malodor, gingival inflammation is also a common oral health problem. If gingival inflammation is not treated promptly, it may develop into more serious periodontal diseases, resulting in tooth loosening or even tooth loss. The occurrence of gingival inflammation is closely related to the accumulation of dental plaque and dental calculus, and the effects of existing oral care products in preventing and treating gingival inflammation vary.

[0005] Currently, there are a wide variety of mouthwash products on the market, but there are significant differences in quality and efficacy. Some mouthwashes can cover up oral malodor in the short term but cannot fundamentally solve the problem; for some mouthwashes that claim to have the efficacy of treating gingival inflammation, their actual effects lack sufficient clinical verification. In addition, some mouthwashes may also contain irritating ingredients, causing discomfort in the user's mouthfeel and even damaging the oral mucosa.

[0006] In such a background, it is of great practical significance to develop a mouthwash that is safe, effective, comfortable in mouthfeel, and can simultaneously improve various oral problems such as oral malodor and gingival inflammation. The silver fruit mouthwash is precisely developed based on these problems, aiming to provide consumers with a better oral care product. Summary of the Invention

[0007] The purpose of the present invention is to provide a silver fruit mouthwash and a preparation method thereof, which have excellent curative effects.

[0008] In order to achieve the above-mentioned invention purpose, the present invention provides the following technical solutions:

[0009] The present invention provides a traditional Chinese medicine mouthwash composition. Calculated by weight parts, the raw materials include the following components:

[0010] 2 - 4 parts of Lonicera hypoglauca Miq., 2 - 4 parts of Scutellaria baicalensis Georgi, 2 - 4 parts of Mentha haplocalyx Briq., 1 - 3 parts of Morus alba L. leaf, 1 - 3 parts of Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang, 1 - 3 parts of Gardenia jasminoides Ellis, 2 - 4 parts of Polygonatum odoratum (Mill.) Druce, 2 - 4 parts of Ophiopogon japonicus (Thunb.) Ker - Gawl., 0.5 - 1.0 part of Stevia rebaudiana Bertoni, 0.8 - 1.2 parts of menthol, 20 - 30 parts of ethanol.

[0011] Preferably, the concentration of the ethanol is 70 - 80% (v / v).

[0012] Preferably, the composition further comprises a pharmaceutically acceptable excipient, and the excipient is selected from at least one of a flavoring agent, a preservative or a solubilizer.

[0013] Preferably, the flavoring agent is selected from xylitol, sorbitol or erythritol; the preservative is selected from sodium benzoate, potassium sorbate or parabens; the solubilizer is selected from polyethylene glycol, Tween series or Span series.

[0014] The present invention also provides a preparation method of the above - mentioned traditional Chinese medicine mouthwash composition, which comprises the following steps:

[0015] (1) Pretreatment: Put Lonicera hypoglauca Miq., Scutellaria baicalensis Georgi, Mentha haplocalyx Briq., Morus alba L. leaf, Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang, Gardenia jasminoides Ellis, Polygonatum odoratum (Mill.) Druce, Ophiopogon japonicus (Thunb.) Ker - Gawl., and Stevia rebaudiana Bertoni into a decoction bag, add cold water 10 - 15 times the total weight of the medicinal materials, and soak for 25 - 35 minutes;

[0016] (2) Decoction extraction: Decoct for the first time until boiling and maintain for 15 - 25 minutes, then filter to obtain the primary decoction; add cold water 8 - 12 times the total weight of the medicinal materials for the second decoction, boil and maintain for 15 - 25 minutes, and filter to obtain the secondary decoction;

[0017] (3) Preparation: Combine the primary decoction and the secondary decoction, and when controlling the temperature of the medicinal liquid at 40 - 50°C, add the menthol solution pre - dissolved in ethanol, and stir and mix evenly;

[0018] (4) Post - treatment: Adjust the pH value to 5.5 - 6.5, filter and sterilize, and then sub - pack.

[0019] Preferably, the preparation method of the menthol solution in step (3) is: dissolve menthol in ethanol with a concentration of 70 - 80%, and use a water bath at 40 - 50°C to assist in dissolution.

[0020] Preferably, the sterilization treatment in step (4) adopts a 0.22μm microporous membrane filtration method or a pasteurization method.

[0021] Preferably, the sub - packing in step (4) adopts a sterile filling process, and the packaging form is selected from glass bottles, plastic bottles or composite film bags.

[0022] The present invention also provides the use of the above-mentioned traditional Chinese medicine mouthwash composition in the preparation of oral care drugs, and the oral care includes treating oral ulcers, relieving gingivitis, improving bad breath or preventing dental caries.

[0023] Preferably, the mouthwash is used by gargling 2 - 4 times a day, with a dosage of 10 - 15 ml each time and a gargling time of 1 - 3 minutes.

[0024] Advantages of the present invention:

[0025] The Yinguo mouthwash provided by the present invention shows positive effects in terms of oral odor, overall oral condition, improvement of gingival inflammation and patient experience, and has traditional Chinese medicine value for maintaining oral health. After being used by many patients, the oral odor has been alleviated to varying degrees. Some patients have reached the significant effect standard, with the odor significantly reduced or hardly detectable beyond 10 cm; many patients are effective, with the bad breath significantly improved and the detectable range reduced to beyond 45 cm. This shows that the Yinguo mouthwash can effectively reduce oral odor and improve breath freshness. The overall oral condition of some patients has improved, changing from states such as dry tongue and palate, more tongue coating and debris, and chapped lips to significant or effective states with moist tongue and palate, less tongue coating and debris, and improved lip condition, which has a certain effect on improving the oral environment, relieving oral dryness and related discomforts. Some patients who originally had gingival inflammation (gingival index 1 - 3) had reduced gingival inflammation and a lower gingival index after use, indicating that the Yinguo mouthwash has a certain effect on relieving gingival inflammation and helps maintain gingival health. In the patient comfort evaluation, most patients have a good evaluation of the taste, smell and overall effect of the mouthwash, mainly concentrated in satisfied (3 points) or very satisfied (4 points), indicating that the mouthwash is relatively easy to accept in terms of use experience and overall effect.

[0026] The Yinguo mouthwash has multiple application values and important significances in the field of oral health, mainly reflected in aspects such as improving oral problems, enhancing the quality of life, meeting market demands and providing references for subsequent research.

[0027] The Yinguo mouthwash shows certain effects in improving oral odor, optimizing the overall oral condition and relieving gingival inflammation. It can effectively reduce oral odor and make the breath fresh, which can enhance the confidence of people with frequent social activities and avoid social embarrassment caused by bad breath. In terms of improving the overall oral condition and gingival inflammation, it can relieve oral dryness, reduce tongue coating and debris, improve chapped lips, reduce gingival inflammation and lower the gingival index, which helps maintain the stability of the oral environment and prevent the further development of oral diseases.

[0028] Good oral health is an important part of physical health. Using Yinguo mouthwash to improve oral problems can enhance the comfort of patients in their daily lives. For example, the improvement in taste and smell allows patients to enjoy daily activities such as eating and communicating more, thus enhancing the overall quality of life. This improvement is particularly important for patients who have been troubled by oral problems for a long time.

[0029] With the increasing attention to oral health, the market demand for mouthwash continues to grow. The emergence of Yinguo mouthwash has enriched the variety of mouthwashes in the market. Its effectiveness in improving oral problems can meet the needs of different consumers, providing more choices for consumers and promoting the diversified development of the mouthwash market.

[0030] The clinical research of Yinguo mouthwash provides valuable experience for the R & D and improvement of similar products. By evaluating its clinical effects, subsequent research can further explore the mechanism of action of the active ingredients, optimize the formula, and improve the product performance. It can also provide a reference for the research direction of other oral care products and promote the development of the entire oral care industry. Brief Description of the Drawings

[0031] Figure 1 For example ① of the clinical efficacy research results;

[0032] Figure 2 For example ② of the clinical efficacy research results;

[0033] Figure 3 For example ③ of the clinical efficacy research results;

[0034] Figure 4 For example ④ of the clinical efficacy research results;

[0035] Figure 5 For example ⑤ of the clinical efficacy research results. Detailed Description of the Invention

[0036] In the traditional Chinese medicine mouthwash composition provided by the present invention:

[0037] Scutellaria baicalensis Georgi is bitter in taste and cold in nature; it belongs to the lung, gallbladder, spleen, stomach, large intestine, and small intestine meridians, clearing heat and drying dampness, purging fire and detoxifying. Modern pharmacological research shows that the decoction of Scutellaria baicalensis Georgi has varying degrees of inhibitory effects on Bacillus dysenteriae, Corynebacterium diphtheriae, Pseudomonas aeruginosa, Salmonella typhi, Salmonella paratyphi, Proteus vulgaris, Staphylococcus aureus, Hemolytic streptococcus, Streptococcus pneumoniae, Neisseria meningitidis, Vibrio cholerae, etc. in vitro. This product also has effects such as antipyretic, antihypertensive, sedative, hepatoprotective, cholagogic, inhibiting intestinal peristalsis, reducing blood lipid, antioxidant, regulating cAMP level, and anti-tumor; the water extract of Scutellaria baicalensis Georgi has an inhibitory effect on prostaglandin biosynthesis.

[0038] Lonicera confusa DC. is sweet in taste and cold in nature, belonging to the lung, heart, and stomach meridians, with the effects of resolving turbidity and dispelling filth, clearing heat and detoxifying, and dispersing wind and heat.

[0039] Gardenia is cold in nature and bitter in taste. It enters the heart and triple burner meridians. It is bitter and cold, clearing and descending. It can clear the triple burner heat, clear the heart fire and relieve restlessness; it can clear the damp heat of the liver and gallbladder in the lower burner; it can clear the heat of the liver and gallbladder;

[0040] Peppermint is pungent and cool in nature. It enters the lung and liver meridians, dispels wind-heat, clears the head and eyes, relieves sore throat and rashes, and soothes the liver and promotes qi circulation. This product has a fragrant aroma that can ward off filth, and can also transform dampness and harmonize the stomach. It can also be used to treat summer heat, dampness, and turbid air, abdominal distension and pain, vomiting, and diarrhea.

[0041] Mulberry leaves are cold in nature, bitter in taste, sweet in taste, light in quality, light and clear, can clear lung heat, moisten lung dryness; enter the liver meridian, and can calm liver yang, clear liver heat, moisten yin and improve eyesight. Modern pharmacological research shows that mulberry leaves have the effects of lowering blood sugar, anti-inflammatory, antibacterial, antiviral, and anti-aging.

[0042] Luo Han Guo tastes sweet and is cool in nature; it enters the lung and large intestine meridians, clears the lungs and relieves sore throat, resolves phlegm and relieves cough, and moistens the intestines and promotes bowel movements.

[0043] Polygonatum odoratum is sweet and neutral in nature. It enters the lung and stomach meridians, nourishes yin and moistens dryness, promotes the production of body fluids and quenches thirst. Polygonatum odoratum is paired with mint: Polygonatum odoratum is sweet, cold and moist in nature, nourishes yin without clinging to evil; mint is light and floating, dispersing and clearing the head;

[0044] Ophiopogon japonicus: sweet, slightly bitter, slightly cold. Enters the heart, lung, and stomach meridians, nourishes yin and produces body fluid, moistens the lungs and relieves cough.

[0045] The technical solutions provided by the present invention are described in detail below in conjunction with the embodiments, but they should not be construed as limiting the protection scope of the present invention.

[0046] Example 1

[0047] Weigh 3g of Flos Lonicerae, 3g of Radix Scutellariae, 3g of Mentha, 2g of Folium Mori, 2g of Monk Fruit, 2g of Gardenia, 3g of Polygonatum, 3g of Radix Ophiopogonis, and 0.6g of Stevia, mix them in a non-woven bag, add about 450ml of cold water, and soak for 30min;

[0048] Transfer the above medicinal materials and soaking liquid into the decoction pot, start decocting, start timing after the water boils, decoct for 20 minutes, filter the residue, add about 450 ml of cold water to the decoction pot, continue decocting, start timing after the water boils, decoct for 20 minutes, filter the residue, combine the two liquid medicines, and transfer the liquid medicines to the packaging machine for standby;

[0049] Weigh 1g of menthol and dissolve it in 25ml of 75% ethanol. Heat in a water bath to dissolve. Transfer the menthol-ethanol solution into the drug solution and mix well.

[0050] Repack in 200ml bottles.

[0051] Example 2

[0052] Weigh 3 g of Lonicera japonica Thunb. var. chinensis (Wats.) Hsu et H. J. Wang, 3 g of Scutellaria baicalensis Georgi, 3 g of Mentha haplocalyx Briq., 2 g of Morus alba L. leaf, 2 g of Momordica grosvenori Swingle, 2 g of Gardenia jasminoides Ellis, 3 g of Polygonatum odoratum (Mill.) Druce, 3 g of Ophiopogon japonicus (Thunb.) Ker-Gawl., and 0.6 g of Stevia rebaudiana Bertoni. Combine the herbs in a non-woven bag, add about 450 ml of cold water, and soak for 30 min.

[0053] Transfer the above-mentioned herbs and the soaking solution to a decocting pot, start decocting, start timing after the water boils, decoct for 20 min, filter the residue, add about 450 ml of cold water to the decocting pot, continue decocting, start timing after the water boils, decoct for 20 min, filter the residue, combine the two decoctions, and transfer the decoction to a packaging machine for standby.

[0054] Weigh 1 g of menthol, dissolve it in 25 ml of sorghum edible wine, heat it in a water bath to dissolve, and transfer it to the decoction to mix evenly.

[0055] Package it, 200 ml per bottle, and it is ready.

[0056] Experimental example

[0057] Conduct a clinical efficacy study on the Yinguo mouthwash prepared in Example 1.

[0058] I. Experimental method

[0059] (I) Research subjects

[0060] Select patients of different age groups to participate in the study, with an age range from 8 to 84 years old, having a wide range of representativeness. When these patients were enrolled, detailed information such as department, name, age, and hospital admission number was recorded.

[0061] (II) Evaluation indicators

[0062] Oral malodor: Grade and evaluate according to the detectable range of the odor. Marked effect means no odor or there is an odor but it cannot be smelled beyond 10 cm; Effective means the halitosis is reduced and it cannot be smelled beyond 45 cm; Ineffective means the odor has not improved, there is a pungent smell, and it can still be smelled beyond 1 m.

[0063] Oral comprehensive condition (including bleeding tendency): Evaluate from the states of the tongue palate, tongue surface, palate, and lips. Marked effect shows that the tongue palate is moist, there is a small amount of tongue coating on the tongue surface, there are a small amount of debris on the palate, and the lips are smooth and without cracks; Effective means the tongue palate is slightly dry, there is a medium amount of tongue coating on the tongue surface, there are a medium amount of debris on the palate, the lips are dry with a small amount of scabs and there are cracks; Ineffective means the tongue palate is dry, there is a large amount of putrid tongue coating on the tongue surface, there are a large amount of debris on the palate, the lips are chapped, there are a large amount of scabs and secretions, and it is easy to bleed.

[0064] Gingival index: 0 point indicates no inflammation, normal gingiva; 1 point indicates mild inflammation, slightly changed gingival color, no bleeding on probing; 2 points indicate moderate inflammation, shiny gingiva, red, swollen, hyperplastic, bleeding on probing; 3 points indicate severe inflammation, obviously red and hyperplastic gingiva, with spontaneous bleeding.

[0065] Patient comfort evaluation: It includes four aspects: taste, smell, overall effect and price, all using a scoring standard of 1 - 4 points. 1 point represents very dissatisfied, 2 points represents dissatisfied, 3 points represents satisfied, and 4 points represents very satisfied.

[0066] (III) Evaluation time

[0067] Each patient was evaluated multiple times at different time points, and the time points were relatively scattered to observe the effect changes of the mouthwash at different usage stages.

[0068] (IV) Usage method

[0069] Usage amount: The amount of mouthwash used each time is about 15 - 20 milliliters. The mouthwash can be poured into an auxiliary tool such as a bottle cap or a measuring cup to determine the appropriate amount.

[0070] Gargling time: The gargling time is about 30 seconds - 1 minute. When gargling, let the mouthwash fully contact all parts of the teeth, gums and mucous membranes in the oral cavity, and make the mouthwash flow by agitating the cheeks and lips to ensure that every corner of the oral cavity can be cleaned.

[0071] Usage frequency: If there are minor inflammation problems in the oral cavity, and following the doctor's advice, use it 3 - 4 times a day after meals. It is not recommended to use it too frequently to avoid destroying the normal flora balance in the oral cavity.

[0072] Precautions for use: Rinse the mouth with clean water before using the mouthwash, which can initially remove food residues in the oral cavity. Spit out the mouthwash and do not swallow it. Try not to rinse the mouth with clean water within half an hour after using the mouthwash to avoid reducing the efficacy of the mouthwash.

[0073] II. Experimental results

[0074] The total number of patients was 216; among them, 175 had marked effects, 36 had effective results, 5 had ineffective results; the total effective rate was 97.68%.

[0075] The results of the example clinical efficacy study are shown in the appendix Figures 1 to 5 .

[0076] Among the numerous patients recorded, a considerable proportion of patients had their oral odor change from the initial obvious state to an effective or marked effect state after using the mouthwash, and the range where the odor could be smelled was significantly reduced.

[0077] In terms of the overall oral condition, positive effects have been achieved in many patients. Some patients have gradually changed from adverse conditions such as dry tongue and palate, more tongue coating and debris, and chapped lips to an effective or markedly effective state with a moist tongue and palate, less tongue coating and debris, and improved lip condition. However, there are still some patients with insignificant improvement and remain in an ineffective state. For example, after using the mouthwash for a period of time, the amount of tongue coating on the tongue surface of some patients has decreased, the debris on the palate has also decreased accordingly, and the chapped lip condition has improved.

[0078] The gingival index reflects the improvement of gingival inflammation in patients. Some patients who originally had gingival inflammation (gingival index of 1-3 points) had their gingival inflammation alleviated and the gingival index decreased after using the mouthwash; however, there were also some patients whose gingival index showed no obvious change or increased. For instance, some patients changed from gingival redness and bleeding on probing (gingival index of 2 points) to mild inflammation (gingival index of 1 point).

[0079] In terms of taste: Most patients rated the taste of the mouthwash as satisfactory (3 points) or very satisfactory (4 points), indicating that the taste of the mouthwash is relatively easy to accept, but there are still a few patients who rated it as unsatisfactory (1-2 points).

[0080] In terms of smell: Most patients were relatively satisfied with the oral smell after using the mouthwash and gave a rating of 3-4 points.

[0081] In terms of the overall effect: Generally speaking, most patients had a positive attitude towards the overall effect of the mouthwash, and the scores were concentrated in the range of 3-4 points.

[0082] The above are only the preferred embodiments of the present invention. It should be noted that for those of ordinary skill in the art, without departing from the principle of the present invention, several improvements and refinements can be made, and these improvements and refinements should also be regarded as the protection scope of the present invention.

Claims

1. A Chinese medicine mouthwash composition, characterized in that: The raw materials include the following components by weight: 2-4 parts of honeysuckle flowers, 2-4 parts of scutellaria baicalensis, 2-4 parts of mint, 1-3 parts of mulberry leaves, 1-3 parts of momordica grosvenori, 1-3 parts of gardenia, 2-4 parts of polygonatum, 2-4 parts of ophiopogon japonicus, 0.5-1.0 parts of stevia, 0.8-1.2 parts of menthol, and 20-30 parts of ethanol.

2. The Chinese medicine mouthwash composition according to claim 1, characterized in that The concentration of the ethanol is 70-80% (v / v).

3. The Chinese medicine mouthwash composition according to claim 1, characterized in that: The composition further comprises a pharmaceutically acceptable excipient, wherein the excipient is selected from at least one of a flavoring agent, a preservative or a solubilizer.

4. The Chinese medicine mouthwash composition according to claim 3, characterized in that: The flavoring agent is selected from xylitol, sorbitol or erythritol; the preservative is selected from sodium benzoate, potassium sorbate or parabens; the solubilizer is selected from polyethylene glycol, Tween series or Span series.

5. A method for preparing the Chinese medicine mouthwash composition according to any one of claims 1 to 4, characterized in that: The following steps are involved: (1) Pretreatment: Put honeysuckle, scutellaria, mint, mulberry leaf, momordica grosvenori, gardenia, polygonatum, ophiopogon japonicus, and stevia into a decoction bag, add cold water 10 to 15 times the total weight of the medicinal materials, and soak for 25 to 35 minutes; (2) Decoction extraction: After boiling for the first time, maintain the boiling temperature for 15 to 25 minutes, and filter to obtain the primary decoction; add cold water 8 to 12 times the total weight of the medicinal materials for the second decoction, maintain the boiling temperature for 15 to 25 minutes, and filter to obtain the secondary decoction; (3) Preparation: Combine the initial decoction and the secondary decoction, add the menthol solution dissolved in ethanol in advance when the temperature of the decoction is controlled at 40-50°C, and stir to mix evenly; (4) Post-treatment: adjust the pH value to 5.5-6.5, filter and sterilize, and then package.

6. The preparation method according to claim 5, characterized in that: The preparation method of the menthol solution in step (3) is as follows: dissolving menthol in 70-80% ethanol, and using a 40-50° C. water bath to assist in dissolution.

7. The preparation method according to claim 5, characterized in that: The sterilization treatment in step (4) adopts 0.22 μm microporous membrane filtration method or pasteurization method.

8. The preparation method according to claim 5, characterized in that: The packaging in step (4) adopts an aseptic filling process, and the packaging form is selected from glass bottles, plastic bottles or composite film bags.

9. Use of the Chinese medicine mouthwash composition according to any one of claims 1 to 4 in the preparation of oral care medicines, characterized in that: The oral care includes treating oral ulcers, relieving gingivitis, improving bad breath or preventing tooth decay.

10. The use according to claim 9, characterized in that: The mouthwash is used in a manner of gargling 2 to 4 times a day, with a usage amount of 10 to 15 ml each time and a gargling time of 1 to 3 minutes.

Images