Positioning position determination method for neutron treatment and treatment auxiliary system

Abstract

The invention relates to the technical field of medical equipment, in particular to a positioning position determining method for neutron therapy and a therapy auxiliary system. Checking whether the treatment table and the auxiliary firmware interfere with the treatment head or not to obtain an auxiliary firmware positioning parameter and a treatment table positioning parameter; after an auxiliary firmware is fixed to the treatment bed according to the auxiliary firmware positioning parameters, the treatment bed is located at the initial center position, and the laser positioning line is aligned with the initial center position, the treatment bed is controlled to move according to the treatment bed positioning parameters, and the alignment position of the moved laser positioning line on the treatment bed is determined as the positioning position of the detected target. According to the invention, the positioning and positioning time of neutron treatment of the detected target is greatly saved, and the inconvenience of frequent CT scanning of the detected target and multiple attempts of verification and positioning of the treatment bed is greatly reduced.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and specifically provides a method for determining the positioning position for neutron therapy and a treatment assistance system. Background Art

[0002] During radiotherapy, accurate positioning and setup can ensure that the radiation beam accurately irradiates the tumor site while minimizing damage to surrounding normal tissues. This helps improve the treatment effect and reduce the risk of complications. Neutron therapy is different from photon radiotherapy. During photon therapy, patient positioning is relatively flexible, while neutron therapy generally belongs to fixed-beam therapy, mostly horizontal-beam therapy. High-flux neutron beams can only be obtained by closely attaching to the collimator. When performing neutron therapy on a patient, an extended treatment head is usually required to improve the treatment accuracy and meet the needs of different treatment sites. Since the treatment head is generally not used during routine patient CT scans, and neutron therapy generally requires the patient to closely attach to the treatment head, this makes it difficult to verify most irradiation schemes from the side (such as the ear direction) because it will cause the treatment head to collide with the treatment couch in advance due to the shoulders before getting close to the patient's head, making the treatment plan unable to be implemented, resulting in having to reposition and scan the CT again. In order to reduce the rework caused by re-scanning the CT (multiple re-scanings may occur), an auxiliary fixture is usually designed to be added to the treatment couch. The auxiliary fixture can move horizontally or vertically on the treatment couch, and the movement step size is the distance between adjacent positioning holes. Let the patient's head and neck lie on the auxiliary fixture to simulate the positioning and setup, so as to verify whether the treatment plan is feasible. If not, the patient needs to continuously try multiple times to determine the optimal positioning and setup scheme, resulting in poor user experience and increasing the positioning and setup time for the patient to undergo neutron therapy.

[0003] Based on this, the present invention provides a method for determining the positioning position for neutron therapy and a treatment assistance system to solve the above technical problems. Summary of the Invention

[0004] In order to overcome the above defects, the method for determining the positioning position for neutron therapy and the treatment assistance system proposed by the present invention solve the technical problem that the existing method requires the object to be examined to continuously try multiple times on the treatment couch to determine the optimal setup scheme, thus increasing the positioning and setup time for neutron therapy.

[0005] In a first aspect, the present invention provides a method for determining the positioning position for neutron therapy, the method comprising:

[0006] Based on the determined irradiation angle and source-skin distance for neutron therapy, check whether the treatment couch and the auxiliary fixture will interfere with the treatment head, and record the auxiliary fixture positioning parameters and treatment couch positioning parameters corresponding to the situation where neither the treatment couch nor the auxiliary fixture interferes with the treatment head;

[0007] After the auxiliary firmware is fixed on the treatment couch according to the positioning parameters of the auxiliary firmware, and the position of the treatment couch is at the initial center position and the laser positioning line is aligned with the initial center position, control the treatment couch to move according to the positioning parameters of the treatment couch, and determine the alignment position of the laser positioning line on the treatment couch after the movement as the setup position of the object to be examined.

[0008] Further, the method further includes: determining the target area and the organs at risk based on the CT image of the object to be examined, and determining the irradiation angle and the source-skin distance for neutron therapy based on the prescription doses of the target area and the organs at risk.

[0009] In some embodiments: The checking whether the treatment couch and the auxiliary firmware will interfere with the treatment head based on the determined irradiation angle and source-skin distance for neutron therapy includes:

[0010] Set the neutron irradiation positioning parameters as the irradiation angle and the source-skin distance;

[0011] Set the position of the treatment couch as the initial center position, determine whether the treatment couch interferes with the treatment head. If so, update the position of the treatment couch until the treatment couch does not interfere with the treatment head and record the updated position, and determine the positioning parameters of the treatment couch according to the updated position. Otherwise, determine the initial center position as the positioning parameters of the treatment couch;

[0012] Set the initial offset of the auxiliary firmware relative to the treatment couch, determine whether the auxiliary firmware interferes with the treatment head. If so, adjust the offset of the auxiliary firmware relative to the treatment couch until the auxiliary firmware does not interfere with the treatment head and record the adjusted offset, and determine the positioning parameters of the auxiliary firmware according to the adjusted offset. Otherwise, determine the initial offset as the positioning parameters of the auxiliary firmware.

[0013] In some embodiments: The determining whether the treatment couch interferes with the treatment head, if so, updating the position of the treatment couch until the treatment couch does not interfere with the treatment head and recording the updated position includes:

[0014] Determine whether the treatment head interferes with the treatment couch;

[0015] If the interference occurs in the vertical direction, update the position of the treatment couch in the vertical direction according to the first preset step length until there is no interference in the vertical direction;

[0016] If the interference occurs in the longitudinal direction, update the position of the treatment couch in the longitudinal direction according to the second preset step length until there is no interference in the longitudinal direction;

[0017] If interference occurs in the lateral direction, update the position of the treatment couch in the lateral direction according to a third preset step length until interference no longer occurs in the lateral direction;

[0018] Record the updated position of the treatment couch;

[0019] Wherein, the vertical direction is the vertically movable direction of the treatment couch, and the lateral direction and the longitudinal direction are the horizontally movable directions of the treatment couch.

[0020] In some embodiments: The determination of whether interference occurs between the auxiliary fixture and the treatment head, and if so, adjusting the offset of the auxiliary fixture relative to the treatment couch until interference no longer occurs between the auxiliary fixture and the treatment head and recording the adjusted offset includes:

[0021] Determine whether interference occurs between the treatment head and the auxiliary fixture;

[0022] If interference occurs in the lateral direction, adjust the offset of the auxiliary fixture relative to the treatment couch in the lateral direction according to a fourth preset step length until interference no longer occurs in the lateral direction;

[0023] If interference occurs in the longitudinal direction, adjust the offset of the auxiliary fixture relative to the treatment couch in the longitudinal direction according to a fifth preset step length until interference no longer occurs in the longitudinal direction;

[0024] Record the adjusted offset of the auxiliary fixture relative to the treatment couch;

[0025] Wherein, the lateral direction and the longitudinal direction are the horizontally movable directions of the auxiliary fixture.

[0026] Further, the method further includes the step of adjusting the positioning position of the object to be examined.

[0027] In some embodiments, the adjustment of the positioning position of the object to be examined includes: determining the placement position of the positioning film on the treatment couch according to the positioning position of the object to be examined, moving the positioning film on the treatment couch based on the placement position to align the positioning mark on the positioning film with the laser positioning line, and adjusting the position where the positioning film is located when the positioning mark is aligned with the laser positioning line as the positioning position of the object to be examined.

[0028] In a second aspect, the present invention provides a treatment assistance system, the system includes a treatment couch, an auxiliary fixture, a laser lamp, a treatment plan formulation module, and an operation control module;

[0029] The treatment couch is used for placing the object to be examined;

[0030] The auxiliary fixture is used for assisting the object to be examined to be positioned on the treatment couch;

[0031] The laser lamp is used to generate a laser positioning line;

[0032] The treatment plan formulation module is used to check whether the treatment couch and the auxiliary fixture will interfere with the treatment head based on the determined irradiation angle and source-skin distance for neutron therapy, and record the auxiliary fixture positioning parameters and treatment couch positioning parameters corresponding to the situation where neither the treatment couch nor the auxiliary fixture interferes with the treatment head;

[0033] The operation control module is used to control the treatment couch to move according to the treatment couch positioning parameters after the auxiliary fixture is fixed on the treatment couch according to the auxiliary fixture positioning parameters, the position of the treatment couch is at the initial center position, and the laser positioning line is aligned with the initial center position, and determine the alignment position of the laser positioning line on the treatment couch after the movement as the setup position of the object to be examined.

[0034] In some embodiments, the treatment couch is connected with a mechanical component, and the operation control module controls the mechanical component connected with the treatment couch to realize controlling the treatment couch to move according to the treatment couch positioning parameters.

[0035] In some embodiments, a plurality of positioning holes are respectively arranged on the treatment couch and the auxiliary fixture, and the treatment couch and the auxiliary fixture are fixedly connected through the positioning holes; the auxiliary fixture positioning parameters are used to determine the positioning holes for fixedly connecting the auxiliary fixture and the treatment couch from the plurality of positioning holes.

[0036] One or more of the above technical solutions of the present invention have at least one or more of the following beneficial effects: In implementing the technical solution of the present invention, first, based on the determined irradiation angle and source-skin distance for neutron therapy, check whether the treatment couch and the auxiliary fixture will interfere with the treatment head, and record the auxiliary fixture positioning parameters and treatment couch positioning parameters corresponding to the situation where neither the treatment couch nor the auxiliary fixture interferes with the treatment head; then, after the auxiliary fixture is fixed on the treatment couch according to the auxiliary fixture positioning parameters, the position of the treatment couch is at the initial center position, and the laser positioning line is aligned with the initial center position, control the treatment couch to move according to the treatment couch positioning parameters, and determine the alignment position of the laser positioning line on the treatment couch after the movement as the setup position of the object to be examined. The solution provided by this application can determine the setup position simply and quickly, greatly saving the positioning and setup time of the object to be examined for neutron therapy. Since the object to be examined only needs to lie on the treatment couch once to complete the positioning and setup, it also greatly reduces the inconvenience of the object to be examined undergoing frequent CT scans and the treatment couch undergoing multiple trial verifications of the setup. Description of the Drawings

[0037] Referring to the accompanying drawings, the disclosure of the present invention will become more readily understandable. It is readily understood by those skilled in the art that these drawings are only for illustrative purposes and are not intended to limit the scope of protection of the present invention. In addition, similar numbers in the figures are used to represent similar components, where:

[0038] Figure 1 is a schematic structural diagram of a treatment assistance system provided by an embodiment of the present application;

[0039] Figure 2 is a schematic diagram of the relative positional relationship between auxiliary fixtures of different shapes and a treatment couch provided by an embodiment of the present application;

[0040] Figure 3 is a main implementation step flowchart of a method for determining a positioning and setup position for neutron therapy provided by an embodiment of the application;

[0041] Figure 4 is a schematic flowchart of a method for determining optimal positioning parameters according to an embodiment of the present application;

[0042] Figure 5 is a schematic diagram of an implementation manner of positioning and setup based on the determined optimal positioning parameters according to an embodiment of the present application.

[0043] 10 - treatment head, 20 - treatment couch, 30 - auxiliary fixture, 40 - treatment plan formulation module, 50 - operation control module, 60 - laser lamp, 21 - positioning holes on the treatment couch, 31 - positioning holes on the auxiliary fixture. Detailed implementation manners

[0044] The following describes some implementation manners of the present invention with reference to the accompanying drawings. Those skilled in the art should understand that these implementation manners are only used to explain the technical principle of the present invention and are not intended to limit the scope of protection of the present invention.

[0045] In the description of the present invention, it should be noted that the orientation or positional relationship indicated by the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc. is based on the orientation or positional relationship shown in the accompanying drawings. It is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus cannot be understood as a limitation of the present invention. In addition, the terms "first", "second", "third" are only used for descriptive purposes and cannot be understood as indicating or implying relative importance. The terms "installation", "connection", "coupling" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be directly connected or indirectly connected through an intermediate medium, and it can be the communication inside two elements.

[0046] Some terms related to the present invention will be explained first here.

[0047] Neutron irradiation positioning parameters: refer to the irradiation angle and the source-skin distance. The irradiation angle refers to the vector direction from the irradiation point of the neutron beam to the centroid of the tumor or the deepest part of the tumor, and the source-skin distance refers to the distance from the center of the radiation source to the irradiation center of the body surface skin.

[0048] Positioning film: A medical consumable used in radiotherapy, mainly for the auxiliary positioning and fixation of the object to be examined (such as a tumor patient).

[0049] A treatment assistance system is used for the positioning and setup of the object to be examined (such as a tumor patient) during neutron capture tumor treatment, as well as the formulation, verification, and execution of the treatment plan.

[0050] Refer to the appendix Figure 1 , Figure 1 is a schematic diagram of a treatment assistance system according to an embodiment of the present invention. It should be understood that the shapes of the various components of the system shown in the figure are all schematic, and the purpose is only to clearly understand the system composition of the present invention and its application scenarios. As Figure 1 The treatment assistance system shown mainly includes a treatment couch 20, an auxiliary fixture 30, a treatment plan formulation module 40, an operation control module 50, and a laser lamp 60. Among them:

[0051] The treatment couch 20 is used to achieve the setup of the object to be examined.

[0052] The auxiliary fixture 30 is used to assist the object to be examined in setting up on the treatment couch 20.

[0053] The laser lamp 60 is used to generate laser positioning lines. For example, the laser lamp 60 usually adopts a cross laser lamp.

[0054] The treatment plan formulation module 40 is used to check whether the treatment couch 20 and the auxiliary fixture 30 will interfere with the treatment head 10 based on the determined irradiation angle and source-skin distance for neutron therapy, and record the auxiliary fixture positioning parameters and treatment couch positioning parameters corresponding when neither the treatment couch 20 nor the auxiliary fixture 30 interferes with the treatment head 10;

[0055] The operation control module 50 is used to control the treatment couch 30 to move according to the treatment couch positioning parameters after the auxiliary fixture 40 is fixed on the treatment couch 30 according to the auxiliary fixture positioning parameters, the position of the treatment couch 30 is at the initial center position, and the laser positioning line is aligned with the initial center position, and determine the alignment position of the laser positioning line on the treatment couch after the movement as the setup position of the object to be examined.

[0056] In practical applications, the treatment couch 20 can move left and right, forward and backward in the horizontal direction, and move up and down in the vertical direction. As shown in the figure, the x-direction and y-direction represent the horizontal direction. Generally, the left-right movement direction is the transverse direction, and the forward-backward movement direction is the longitudinal direction. The z-direction represents the vertical direction. For example, in a specific embodiment, the treatment couch can be connected with a mechanical component, and the operation control module controls the mechanical component connected to the treatment couch to control the treatment couch to move according to the treatment couch positioning parameters. The treatment couch positioning parameters can be used to determine the position of the treatment couch in the horizontal and vertical directions. For example, the mechanical component can be a lifting device or a moving component such as a slide rail.

[0057] In practical applications, the auxiliary fixture 30 is usually horizontally placed on the treatment couch 20, as Figure 2 shown in the schematic diagram of the relative position relationship between the auxiliary fixtures of different shapes provided by the embodiments of the present application and the treatment couch. As Figure 2 shown, a plurality of positioning holes 21 and 31 are respectively provided on the treatment couch 20 and the auxiliary fixture 30. The treatment couch 20 and the auxiliary fixture 30 are fixedly connected through the positioning holes. The auxiliary fixture 30 can move left and right and forward and backward in the horizontal direction. As shown in the figure, the x-direction and y-direction represent the horizontal direction (transverse direction and longitudinal direction), that is, move left and right in the transverse direction and move forward and backward in the longitudinal direction. Among them, the auxiliary fixture positioning parameters can be used to determine the fixed position of the auxiliary fixture 30 relative to the treatment couch 20, that is, according to the auxiliary fixture positioning parameters, the positioning hole 41 used to fixedly connect the auxiliary fixture 30 and the treatment couch 20 can be determined from a plurality of positioning holes.

[0058] In Figure 1 the basis of the treatment assistance system shown, the method for determining the positioning position for neutron therapy provided by the embodiments of the present invention mainly includes the steps of determining the treatment couch positioning parameters and the auxiliary fixture positioning parameters and the step of determining the positioning position of the object to be examined based on the auxiliary fixture positioning parameters and the treatment couch positioning parameters. Further, after determining the positioning position of the object to be examined, it may further include the step of adjusting the positioning position of the object to be examined, that is, moving the treatment couch through the positioning parameters and combining the laser positioning line to complete the approximate position of the patient's pre-positioning, and then completing the accurate pre-positioning position through the positioning film marking. In the complete implementation application scenario of positioning and positioning in neutron therapy, after determining the pre-positioning position, the synchronous bed moving positioning will be completed in sequence through the relative offset between the isocenter of the patient treatment plan and the user origin, and the final synchronous bed moving positioning will be completed through the X-ray image guidance system, so as to complete the complete implementation of positioning and positioning.

[0059] Refer to the appendix Figure 3 , Figure 3It is a schematic flowchart of a specific implementation method for determining the positioning position for neutron therapy provided by an embodiment of the present invention. Among them, step S11 corresponds to the specific implementation method for determining the positioning parameters of the treatment couch to assist the positioning parameters of the fixture, and step S12 corresponds to the specific implementation method for determining the positioning position of the object to be examined based on the positioning parameters of the fixture and the positioning parameters of the treatment couch. The specific steps of step S11 and step S12 shown in the figure are as follows:

[0060] Step S11: Based on the determined irradiation angle and source-skin distance for neutron therapy, check whether the treatment couch and the fixture will interfere with the treatment head, and record the positioning parameters of the fixture and the positioning parameters of the treatment couch corresponding to the situation where neither the treatment couch nor the fixture will interfere with the treatment head.

[0061] In this embodiment, the determined irradiation angle and source-skin distance for neutron therapy can be determined based on manual experience or can be determined by the treatment plan formulation module through designing an automatic optimization method. Among them, the method for determining the irradiation angle and source-skin distance based on the treatment plan formulation module is not specifically limited in this embodiment. It can be determined in any way that those skilled in the art can think of based on the CT images of the object to be examined to determine the target area and organs at risk, and based on the prescription doses of the target area and organs at risk.

[0062] Step S12: After the fixture is fixed on the treatment couch according to the positioning parameters of the fixture, and the position of the treatment couch is at the initial center position and the laser positioning line is aligned with the initial center position, control the treatment couch to move according to the positioning parameters of the treatment couch, and determine the alignment position of the laser positioning line on the treatment couch after the movement as the positioning position of the object to be examined.

[0063] In practical applications, after the above step S12, it may further include the step of adjusting the positioning position of the object to be examined. The specific implementation method can be: determine the placement position of the positioning film on the treatment couch according to the positioning position of the object to be examined determined in step S12, move the positioning film on the treatment couch based on the placement position to align the positioning mark on the positioning film with the laser positioning line, and adjust the position where the positioning film is located when the positioning mark is aligned with the laser positioning line as the positioning position of the object to be examined.

[0064] In a specific embodiment, the above step S11 can be implemented by a treatment plan formulation module. The treatment plan formulation module can perform anti-interference judgment based on set parameters (such as neutron irradiation positioning parameters, parameters representing the positions of the treatment head, treatment couch, and auxiliary fixtures, parameters representing the movement step size, etc.), and can automatically update relevant parameters according to the judgment result and finally output parameters representing the relative positions of the treatment couch and the auxiliary fixtures when no interference occurs (such as the treatment couch positioning parameters and auxiliary fixture positioning parameters in this embodiment). The inspection of whether the treatment couch and the auxiliary fixtures will interfere with the treatment head based on the determined irradiation angle and source-skin distance for neutron therapy in step S11 can specifically include the following steps 111 to 113:

[0065] Step 111: Set the neutron irradiation positioning parameters as the irradiation angle and the source-skin distance;

[0066] Step 112: Set the position of the treatment couch as the initial center position, judge whether the treatment couch interferes with the treatment head. If so, update the position of the treatment couch until the treatment couch does not interfere with the treatment head and record the updated position, and determine the treatment couch positioning parameters according to the updated position. Otherwise, determine the initial center position as the treatment couch positioning parameters;

[0067] Exemplarily, if the initial center position is (X1, Y1, Z1) and the updated position is (X2, Y2, Z2), the treatment couch positioning parameters determined according to the updated position can be recorded as (X2, Y2, Z2), or as (X2 - X1, Y2 - Y1, Z2 - Z1), where X2 - X1 represents the lateral direction offset of the treatment couch relative to the initial center position, Y2 - Y1 represents the longitudinal direction offset of the treatment couch relative to the initial center position, and Z2 - Z1 represents the vertical direction offset of the treatment couch relative to the initial center position. The vertical direction here can be understood as the vertically movable direction of the treatment couch, and the lateral direction and the longitudinal direction can be understood as the horizontally movable directions of the treatment couch. It should be understood that the initial center position can be understood as the initial positioning position of the object to be examined on the treatment couch, and the treatment couch positioning parameters can be understood as the re-determined positioning position of the object to be examined on the treatment couch. The movement of the treatment couch can be realized by operating a control module to control the mechanical components connected to the treatment couch to move the treatment couch in the lateral direction, longitudinal direction, and vertical direction. The movement step size adopted for updating the position of the treatment couch can be set with different step sizes for different directions respectively. The total step size that the treatment couch needs to move relative to the initial center position can be determined according to the lateral direction offset, longitudinal direction offset, and vertical direction offset in the treatment couch positioning parameters.

[0068] Step 113: Set the initial offset of the auxiliary firmware relative to the treatment couch, and determine whether there is interference between the auxiliary firmware and the treatment head. If so, adjust the offset of the auxiliary firmware relative to the treatment couch until there is no interference between the auxiliary firmware and the treatment head, and record the adjusted offset. Determine the positioning parameters of the auxiliary firmware according to the adjusted offset. Otherwise, determine the initial offset as the positioning parameters of the auxiliary firmware.

[0069] Exemplarily, if the initial offset is (u1, v1) and the adjusted offset is (u2, v2), the positioning parameters of the auxiliary firmware determined according to the adjusted offset can be denoted as (u2, v2), where u2 represents the lateral direction offset of the auxiliary firmware relative to the treatment couch, and v2 represents the longitudinal direction offset of the auxiliary firmware relative to the treatment couch. The lateral direction and the longitudinal direction here can be understood as the horizontal movable directions of the auxiliary firmware. It should be understood that the auxiliary firmware and the treatment couch are usually fixedly connected by positioning holes. Therefore, the movement step size for adjusting the offset of the auxiliary firmware relative to the treatment couch can be the distance between adjacent positioning holes. The lateral positioning hole can be determined according to the lateral direction offset of the positioning parameters of the auxiliary firmware, and the longitudinal positioning hole can be determined according to the longitudinal direction offset. Then, the auxiliary firmware is fixed on the treatment couch according to the determined lateral positioning hole and longitudinal positioning hole.

[0070] Further, based on the above Step 112, where determining whether there is interference between the treatment couch and the treatment head, if so, updating the position of the treatment couch until there is no interference between the treatment couch and the treatment head and recording the updated position can specifically include the following a1 and a2:

[0071] a1. Determine whether there is interference between the treatment head and the treatment couch;

[0072] If there is interference in the vertical direction, update the position of the treatment couch in the vertical direction according to the first preset step size until there is no interference in the vertical direction;

[0073] If there is interference in the longitudinal direction, update the position of the treatment couch in the longitudinal direction according to the second preset step size until there is no interference in the longitudinal reverse direction;

[0074] If there is interference in the lateral direction, update the position of the treatment couch in the lateral direction according to the third preset step size until there is no interference in the lateral direction;

[0075] a2. Record the updated position of the treatment couch.

[0076] Exemplarily, the first preset step size can be set to 1 centimeter, the second preset step size can be set to the distance between adjacent longitudinal positioning holes, and the third preset step size can be set to the distance between adjacent lateral positioning holes.

[0077] Based on the above step 112, the judgment of whether there is interference between the auxiliary firmware and the treatment head, and if so, adjusting the offset of the auxiliary firmware relative to the treatment bed until there is no interference between the auxiliary firmware and the treatment head and recording the adjusted offset can specifically include the following b1 and b2:

[0078] b1. Judge whether there is interference between the treatment head and the auxiliary firmware;

[0079] If there is interference in the lateral direction, adjust the offset of the auxiliary firmware relative to the treatment bed in the lateral direction according to the fourth preset step length until there is no interference in the lateral direction;

[0080] If there is interference in the longitudinal direction, adjust the offset of the auxiliary firmware relative to the treatment bed in the longitudinal direction according to the fifth preset step length until there is no interference in the longitudinal direction;

[0081] b2. Record the adjusted offset of the auxiliary firmware relative to the treatment bed.

[0082] Wherein, the lateral direction and the longitudinal direction are the horizontally movable directions of the auxiliary firmware, the fourth preset step length can be set as the distance between adjacent lateral positioning holes, and the fifth preset step length can be set as the distance between adjacent longitudinal positioning holes.

[0083] In a specific implementation manner, the present invention first completes the delineation of the target area and the organs at risk and the formulation of the neutron treatment plan based on the patient's scanned CT in sequence, and then determines the positioning and setup parameters (lateral offset, longitudinal offset, vertical offset) and the position of the auxiliary firmware relative to the treatment bed (lateral offset and longitudinal offset) based on the irradiation parameters of the neutron treatment plan and the treatment bed / auxiliary firmware parameters. Then, the treatment bed is first reset to the initial center position of the treatment bed (the vertical coordinate is located on the upper surface of the bed board) and aligned with this center position by laser positioning. The auxiliary firmware is fixed on the treatment bed according to the calculated lateral offset and longitudinal offset. Then, the positioning and setup parameters are applied to the treatment bed and the treatment bed is controlled to move to the corresponding position. At this time, the updated position of the laser positioning on the treatment bed is the optimal positioning and setup position of the patient lying on the treatment bed. Finally, the synchronous bed movement positioning is completed through the relative offset between the isocenter of the patient treatment plan and the user origin, and the final synchronous bed movement positioning is completed through the X-ray image guidance system (correcting the small deviations caused by the laser positioning and the subtle changes in the patient's anatomical structure). For the specific implementation manner, please refer to the appendix Figure 4 and Figure 5 。

[0084] Figure 4 is the flow of an optimal positioning parameter determination method provided in this embodiment. In this embodiment, it is specifically used to determine the treatment bed positioning parameters and the auxiliary firmware positioning parameters of the neutron treatment plan, such asFigure 4 It mainly includes the following steps from step 201 to step 215:

[0085] Step 201: Obtain the patient's CT scan image;

[0086] Step 202: Complete the delineation of the target area and organs at risk based on the CT scan image;

[0087] Step 203: Complete the formulation of the neutron treatment plan based on the prescription dose requirements of the target area and organs at risk, and obtain the determined irradiation angle and source-skin distance (the relative position between the treatment head and the patient is determined);

[0088] Step 204: Record the initial central position (X1, Y1, Z1) of the treatment couch;

[0089] Step 205: Conduct an interference check on the treatment head and the treatment couch at this irradiation angle and source-skin distance;

[0090] Step 206: Judge whether there is interference between the treatment head and the treatment couch in the vertical direction. If so, update and adjust the vertical offset by a step size of 1 cm, and then return to execute step 205. Otherwise, execute step 207;

[0091] Step 207: Judge whether there is interference between the treatment head and the treatment couch in the longitudinal direction. If so, update and adjust the longitudinal offset by a step size of A (A is the distance between adjacent longitudinal positioning holes, 1 ≤ A ≤ 10 cm), and then return to execute step 205. Otherwise, execute step 208;

[0092] Step 208: Judge whether there is interference between the treatment head and the treatment couch in the transverse direction. If so, update and adjust the transverse offset by a step size of B (B is the distance between adjacent transverse positioning holes, 1 ≤ B ≤ 10 cm), and then return to execute step 205. Otherwise, execute step 209;

[0093] Step 209: Record the updated position (X2, Y2, Z2) of the treatment couch;

[0094] Step 210: Record (X2 - X1, Y2 - Y1, Z2 - Z1) as the treatment couch positioning parameter of the patient relative to the treatment couch;

[0095] Step 211: Record the initial offset (U1, V1) of the auxiliary fixture relative to the treatment couch;

[0096] Step 212: Judge whether there is interference between the treatment head and the auxiliary fixture in the transverse direction. If so, update and adjust the transverse offset by a step size of C (C is the distance between adjacent transverse positioning holes, 1 ≤ C ≤ 10 cm), and continue to execute step 212. Otherwise, execute step 213;

[0097] Step 213: Determine whether there is interference between the treatment head and the auxiliary fixture in the longitudinal direction. If so, update and adjust the longitudinal offset according to the step size D, where D is the distance between longitudinally adjacent positioning holes (1 ≤ D ≤ 10 cm), and return to execute Step 212. Otherwise, execute Step 214;

[0098] Step 214: Record the updated offset (U2, V2) of the auxiliary fixture relative to the treatment couch, and use it as the positioning parameter for the accessory fixture;

[0099] Step 215: Complete the determination of the treatment plan positioning parameters and end.

[0100] Figure 5 It is a schematic diagram of an implementation method for positioning and setup based on the determined optimal positioning parameters provided in this embodiment. As shown in Figure 5 the following steps 301 to 307 are mainly included:

[0101] Step 301: Based on the positioning parameters (U2, V2) of the auxiliary fixture obtained through optimization calculation, complete the installation and positioning of the auxiliary fixture on the treatment couch;

[0102] Step 302: Reset the treatment couch, and position the cross laser lamp at the initial center position of the treatment couch. At this time, the patient does not get on the couch;

[0103] Step 303: Based on the positioning parameters of the treatment couch obtained through optimization calculation, complete the movement of the treatment couch. At this time, the relative position of the cross laser line on the treatment couch is updated;

[0104] Step 304: Place the positioning film on the treatment couch. The treatment couch does not move, and the positioning film moves on the treatment couch to align the positioning mark on the positioning film with the cross laser positioning line;

[0105] Step 305: Remove the positioning film, and let the patient lie on the treatment couch to ensure that the position where the patient lies corresponds to the position of the positioning film, completing the pre-setup of the patient on the treatment couch;

[0106] Step 306: Based on the relative offset between the isocenter of the patient's treatment plan and the user origin, complete the bed movement positioning (the patient moves synchronously with the treatment couch);

[0107] Step 307: Based on the X-ray image guidance system, complete the bed movement positioning (the patient moves synchronously with the treatment couch).

[0108] Based on a full understanding of the significant differences between the patient CT scanning scenario and the treatment scenario in the neutron treatment process, and comprehensively considering the universality of patient CT scanning, the personalization of patient treatment plans, and the accuracy and convenience of positioning and setup, the present invention proposes an optimized positioning and setup method for neutron treatment plans. On the premise that the patient treatment plan is completed, the specific positioning position of the patient relative to the treatment couch without interference and safety is calculated by quickly optimizing the initial center of the treatment couch and the three directions of horizontal, longitudinal, and vertical. Then, the specific positioning position of the auxiliary fixture relative to the treatment couch without interference and safety is calculated by quickly optimizing the initial position of the auxiliary fixture and the two directions of horizontal and longitudinal. Finally, the pre-setup of the patient on the treatment couch is completed by combining the cross laser positioning line and the positioning film marking, greatly saving the positioning and setup time for the patient to undergo neutron treatment and minimizing the trial-and-error positioning and setup of the patient lying randomly on the bed during secondary CT scanning.

[0109] It should be noted that although the above embodiments describe the various steps in a specific order, those skilled in the art can understand that in order to achieve the effects of the present invention, different steps do not necessarily have to be executed in such an order. They can be executed simultaneously (in parallel) or in other orders, and these variations are all within the protection scope of the present invention.

[0110] Those skilled in the art can understand that all or part of the processes in the method of the above embodiments of the present invention can also be completed by instructing relevant hardware through a computer program. The computer program can be stored in a computer-readable storage medium. When the computer program is executed by a processor, the steps of the above various method embodiments can be implemented. Among them, the computer program includes computer program code, and the computer program code can be in the form of source code, object code, executable file, or some intermediate form, etc. The computer-readable storage medium can include: any entity or device, medium, USB flash drive, mobile hard disk, magnetic disk, optical disc, computer memory, read-only memory, random access memory, electrical carrier signal, telecommunication signal, and software distribution medium that can carry the computer program code.

[0111] So far, the technical solution of the present invention has been described in combination with the preferred embodiments shown in the drawings. However, those skilled in the art can easily understand that the protection scope of the present invention is obviously not limited to these specific embodiments. Without departing from the principle of the present invention, those skilled in the art can make equivalent changes or substitutions to the relevant technical features, and the technical solutions after these changes or substitutions will all fall within the protection scope of the present invention.

Claims

1. A method for determining a positioning position for neutron therapy, characterized in that: The method comprises: Based on the determined irradiation angle and source-skin distance for neutron therapy, checking whether the treatment couch and the auxiliary firmware will interfere with the treatment head, and recording the auxiliary firmware positioning parameters and treatment couch positioning parameters corresponding to when the treatment couch and the auxiliary firmware will not interfere with the treatment head; After the auxiliary firmware is fixed on the treatment bed according to the auxiliary firmware positioning parameters, the position of the treatment bed is at an initial center position and the laser positioning line is aligned with the initial center position, the treatment bed is controlled to move according to the treatment bed positioning parameters, and the aligned position of the laser positioning line on the treatment bed after the movement is determined as the placement position of the inspected object.

2. The method according to claim 1, characterized in that The method further comprises: determining the target area and the organ at risk based on the CT image of the inspected object, and determining the irradiation angle and source-skin distance for neutron therapy based on the prescription dose of the target area and the organ at risk.

3. The method according to claim 1, characterized in that: The checking of whether the treatment bed and the auxiliary firmware will interfere with the treatment head based on the determined irradiation angle and source-skin distance for neutron therapy includes: Setting the neutron irradiation positioning parameters to the irradiation angle and the source-skin distance; Setting the position of the treatment bed as the initial center position, determining whether the treatment bed and the treatment head interfere with each other, if yes, updating the position of the treatment bed until the treatment bed and the treatment head do not interfere with each other and recording the updated position, determining the treatment bed positioning parameters according to the updated position, otherwise determining the initial center position as the treatment bed positioning parameters; An initial offset of the auxiliary firmware relative to the treatment bed is set, and it is determined whether the auxiliary firmware interferes with the treatment head. If so, the offset of the auxiliary firmware relative to the treatment bed is adjusted until the auxiliary firmware does not interfere with the treatment head and the adjusted offset is recorded. A positioning parameter of the auxiliary firmware is determined according to the adjusted offset. Otherwise, the initial offset is determined as the positioning parameter of the auxiliary firmware.

4. The method according to claim 3, characterized in that: The determining whether the treatment bed and the treatment head interfere with each other, and if yes, updating the position of the treatment bed until the treatment bed and the treatment head do not interfere with each other and recording the updated position includes: Determine whether there is interference between the treatment head and the treatment bed; If interference occurs in the vertical direction, the position of the treatment bed is updated in the vertical direction according to the first preset step length until no interference occurs in the vertical direction; If interference occurs in the longitudinal direction, the position of the treatment bed is updated in the longitudinal direction according to the second preset step length until no interference occurs in the reverse longitudinal direction; If interference occurs in the lateral direction, updating the position of the treatment bed in the lateral direction according to the third preset step length until no interference occurs in the lateral direction; Record the updated location of the treatment bed; The vertical direction is the vertical movable direction of the treatment bed, and the transverse direction and the longitudinal direction are the horizontal movable directions of the treatment bed.

5. The method according to claim 3, characterized in that: The determining whether the auxiliary firmware and the treatment head interfere with each other, and if so, adjusting the offset of the auxiliary firmware relative to the treatment bed until the auxiliary firmware and the treatment head do not interfere with each other and recording the adjusted offset includes: Determine whether the treatment head and the auxiliary firmware interfere with each other; If interference occurs in the lateral direction, adjusting the offset of the auxiliary fixture relative to the treatment bed in the lateral direction according to the fourth preset step length until no interference occurs in the lateral direction; If interference occurs in the longitudinal direction, adjusting the offset of the auxiliary fixture relative to the treatment bed in the longitudinal direction according to the fifth preset step length until no interference occurs in the reverse longitudinal direction; Record the offset of the adjusted auxiliary firmware relative to the treatment bed; The transverse direction and the longitudinal direction are horizontal movable directions of the auxiliary fixture.

6. The method according to claim 1, characterized in that The method also includes the step of adjusting the position of the inspected object.

7. The method according to claim 6, characterized in that The adjusting the setup position of the inspected object includes: determining the placement position of a positioning film on the treatment bed according to the setup position of the inspected object, moving the positioning film on the treatment bed based on the placement position to align a positioning mark on the positioning film with the laser positioning line, and adjusting the position of the positioning film when the positioning mark is aligned with the laser positioning line to the setup position of the inspected object.

8. A treatment assistance system, characterized in that: The system includes a treatment bed, auxiliary firmware, a laser light, a treatment plan formulation module and an operation control module; The treatment bed is used to place the object to be inspected; The auxiliary firmware is used to assist the object to be inspected in positioning on the treatment bed; The laser lamp is used to generate a laser positioning line; The treatment plan making module is used to check whether the treatment bed and the auxiliary firmware will interfere with the treatment head based on the determined irradiation angle and source-skin distance for neutron treatment, and record the auxiliary firmware positioning parameters and treatment bed positioning parameters corresponding to when the treatment bed and the auxiliary firmware will not interfere with the treatment head; The operation control module is used to control the treatment bed to move according to the positioning parameters of the treatment bed after the auxiliary firmware is fixed on the treatment bed according to the positioning parameters of the auxiliary firmware and the position of the treatment bed is at an initial center position and the laser positioning line is aligned with the initial center position, and determine the aligned position of the laser positioning line on the treatment bed after the movement as the placement position of the inspected object.

9. The system according to claim 8, characterized in that The treatment bed is connected to a mechanical component, and the operation control module controls the mechanical component connected to the treatment bed to control the treatment bed to move according to the positioning parameters of the treatment bed.

10. The system according to claim 8, characterized in that The treatment bed and the auxiliary fixture are respectively provided with a plurality of positioning holes, and the treatment bed and the auxiliary fixture are fixedly connected through the positioning holes; and the auxiliary fixture positioning parameter is used to determine, from the plurality of positioning holes, a positioning hole for fixing the auxiliary fixture to the treatment bed.

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