Monoclonal antibody against monkeypox virus m1r protein and use thereof

CN120137011BActive Publication Date: 2026-05-26INST OF MICROBIOLOGY CHINESE ACAD OF SCI
View PDF 2 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
INST OF MICROBIOLOGY CHINESE ACAD OF SCI
Filing Date
2025-03-17
Publication Date
2026-05-26

AI Technical Summary

Technical Problem

The lack of high-affinity and in vitro neutralizing monkeypox virus antibodies in existing technologies makes it difficult to prevent and control monkeypox virus infection. Furthermore, monkeypox virus mutates rapidly during human-to-human transmission, threatening global public health security.

Method used

Monoclonal antibodies against monkeypox virus M1R protein were developed. By screening fully humanized mice with antibodies, monoclonal antibodies M1R-12E10, M1R-12H5, M1R-12H6, M1R-24A7, and M1R-24H1 with strong specific binding ability, high affinity, and good in vitro neutralization were obtained. These antibodies were then expressed and purified in host cells using expression vectors.

Benefits of technology

These monoclonal antibodies exhibit good binding and neutralizing properties in vitro, providing protection against vaccinia virus and offering detection and treatment products for monkeypox virus, thus enabling the prevention and treatment of monkeypox virus infection.

✦ Generated by Eureka AI based on patent content.

Smart Images

  • Figure BDA0005314065620000051
    Figure BDA0005314065620000051
  • Figure BDA0005314065620000061
    Figure BDA0005314065620000061
  • Figure BDA0005314065620000071
    Figure BDA0005314065620000071
Patent Text Reader

Abstract

This application discloses monoclonal antibodies against monkeypox virus M1R protein and their applications. Specifically, this application discloses several antibodies (M1R-12E10, M1R-12H5, M1R-12H6, M1R-24A7, M1R-24H1) that have good specificity and affinity for M1R protein, and that they have good neutralizing activity and certain in vivo protective effects.
Need to check novelty before this filing date? Find Prior Art