Traditional Chinese medicine composition for treating phlegm-heat accumulation type nodule diseases and application of traditional Chinese medicine composition

Abstract

The traditional Chinese medicine composition for treating phlegm-heat accumulation type nodule diseases is prepared from the following raw materials in parts by weight: 5 to 50 parts of radix ranunculi ternati, 5 to 60 parts of spica prunellae, 3 to 40 parts of spina gleditsiae, 1 to 5 parts of lapis lazuli, 3 to 20 parts of vinegar-processed rhizoma curcumae, 3 to 30 parts of fried tribulus terrestris, 5 to 40 parts of calcined clam shells, 4 to 30 parts of vinegar-processed radix curcumae, 1 to 15 parts of herba lagotis and 1 to 5 parts of adhatoda vasica. The traditional Chinese medicine composition is scientific and reasonable in formula compatibility and low in cost, has the effects of soothing liver-qi stagnation and reducing phlegm and resolving masses, can be effectively used for treating phlegm-heat accumulation type nodule diseases, is stable and reliable in curative effect and good in effect, is a great innovation in medicine for treating phlegm-heat accumulation type nodule diseases, and has huge social and economic benefits.

Description

Technical Field

[0001] The present invention relates to the field of medicine, and in particular to a traditional Chinese medicine composition for treating nodular diseases with internal accumulation of phlegm-heat and its application. Background Art

[0002] A nodule is a mass formed by abnormal hyperplasia of tissues, which can appear in multiple organs. For example, nodules may occur in the thyroid, lungs, liver, mammary glands, etc. According to their nature, nodules can be divided into benign and malignant, and malignant nodules may develop into cancer. The causes of nodules are complex and involve multiple factors such as genetics, environment, infection, inflammation, and immune responses. For example, thyroid nodules are related to iodine intake and genetic mutations, while lung nodules are associated with smoking, environmental pollution, and infection. Currently, the clinical diagnosis of nodular diseases mainly combines clinical manifestations, imaging examinations, and histopathological examinations, while excluding other diseases. The treatment plan depends on the nature and location of the nodules. Benign nodules are usually treated conservatively or surgically removed, while malignant nodules require surgery, radiotherapy, chemotherapy, or targeted therapy. The development of minimally invasive surgery and targeted drugs has improved the prognosis of patients. With the progress of imaging technology, more nodules are still in the early stage when discovered, and Western medicine mostly adopts conservative treatment plans, giving anti-inflammatory and other symptomatic treatments, but the effect is very small. In the field of traditional Chinese medicine, nodular diseases can be classified into "accumulation", "phlegm injection", "phlegm node", etc. The name of "accumulation" was first seen in "Huangdi Neijing". For example, in "Ling Shu·Wu Bian", it is said: "Those who are prone to accumulate in the intestines... have thin and inelastic skin, and soft and moist flesh. In this case, the gastrointestinal tract is weak, and when the pathogenic qi stays, accumulation will occur." In terms of treatment, "Su Wen·Zhi Zhen Yao Da Lun" put forward "reduce the hard ones", "disperse the knot ones", "attack the retained ones", which has general guiding significance. "Dan Xi Xin Fa" records: "Many diseases are accompanied by phlegm, which is unknown to the world. There are tubercles in the human body, which do not hurt, do not turn red, and do not suppurate, which is phlegm injection." Therefore, traditional Chinese medicine has certain effects in treating nodular diseases. Although there are currently traditional Chinese medicines for treating nodular diseases, there has been no relevant public report on a traditional Chinese medicine composition specifically for nodular diseases with internal accumulation of phlegm-heat. Summary of the Invention

[0003] In view of the above situation, in order to overcome the defects of the prior art, the purpose of the present invention is to provide a traditional Chinese medicine composition for treating nodular diseases with internal accumulation of phlegm-heat and its application, which can effectively solve the medication problem of nodular diseases with internal accumulation of phlegm-heat.

[0004] To achieve the above purpose, the technical solution solved by the present invention is that a traditional Chinese medicine composition for treating nodular diseases with internal accumulation of phlegm-heat includes the following raw materials in parts by weight: 5 - 50 parts of cat's claw grass, 5 - 60 parts of selfheal spike, 3 - 40 parts of saponary acanthus, 1 - 5 parts of lapis lazuli, 3 - 20 parts of vinegar processed zedoary, 3 - 30 parts of stir-fried tribulus terrestris, 5 - 40 parts of calcined concha meretricis seu cyclinae, 4 - 30 parts of vinegar processed turmeric, 1 - 15 parts of lagotis glauca, and 1 - 5 parts of justicia adhatoda.

[0005] Use of the described traditional Chinese medicine composition for treating nodular diseases with internal accumulation of phlegm-heat in the preparation of drugs for treating nodular diseases with internal accumulation of phlegm-heat.

[0006] The described drug is selected from decoction, plaster, traditional Chinese medicine application, medicinal liquor, elixir, tablet, capsule or granule.

[0007] The formula of the present invention is scientifically and rationally combined, with low cost, and has the effects of soothing the liver and relieving depression, resolving phlegm and dissipating nodules. It can be effectively used to treat nodular diseases with internal accumulation of phlegm-heat, with stable and reliable curative effect and good effect. It is a major innovation in drugs for treating nodular diseases with internal accumulation of phlegm-heat, and has great social and economic benefits. Detailed implementation mode

[0008] The following will make a detailed description of the specific implementation mode of the present invention in combination with examples and specific situations.

[0009] When the present invention is specifically implemented, it is given by the following examples. Example 1

[0010] A traditional Chinese medicine composition for treating nodular diseases with internal accumulation of phlegm-heat, comprising the following raw materials by weight: 5 parts of cat's claw grass, 5 parts of selfheal spike, 3 parts of Chinese honey locust spine, 1 part of lapis lazuli, 3 parts of vinegar zedoary, 3 parts of stir-fried puncturevine caltrop fruit, 5 parts of calcined clam shell, 4 parts of vinegar turmeric, 1 part of lagotis glauca and 1 part of justicia adhatoda. Example 2

[0011] A traditional Chinese medicine composition for treating nodular diseases with internal accumulation of phlegm-heat, comprising the following raw materials by weight: 50 parts of cat's claw grass, 60 parts of selfheal spike, 40 parts of Chinese honey locust spine, 5 parts of lapis lazuli, 20 parts of vinegar zedoary, 30 parts of stir-fried puncturevine caltrop fruit, 40 parts of calcined clam shell, 30 parts of vinegar turmeric, 15 parts of lagotis glauca and 5 parts of justicia adhatoda. Example 3

[0012] A traditional Chinese medicine composition for treating nodular diseases with internal accumulation of phlegm-heat, comprising the following raw materials by weight: 27 parts of cat's claw grass, 32 parts of selfheal spike, 21 parts of Chinese honey locust spine, 3 parts of lapis lazuli, 11 parts of vinegar zedoary, 16 parts of stir-fried puncturevine caltrop fruit, 22 parts of calcined clam shell, 17 parts of vinegar turmeric, 8 parts of lagotis glauca and 3 parts of justicia adhatoda. Example 4

[0013] A traditional Chinese medicine composition for treating nodular diseases with internal accumulation of phlegm-heat, comprising the following raw materials by weight: 10 parts of cat's claw grass, 50 parts of selfheal spike, 30 parts of Chinese honey locust spine, 2 parts of lapis lazuli, 18 parts of vinegar zedoary, 10 parts of stir-fried puncturevine caltrop fruit, 15 parts of calcined clam shell, 25 parts of vinegar turmeric, 5 parts of lagotis glauca and 2 parts of justicia adhatoda. Example 5

[0014] A traditional Chinese medicine composition for treating nodular diseases of endogenous phlegm-heat type comprises the following raw materials in parts by weight: 40 parts of cat's claw, 10 parts of selfheal, 10 parts of sapodilla thorn, 4 parts of lapis lazuli, 7 parts of vinegared zedoaria, 20 parts of stir-fried tribulus terrestris, 10 parts of calcined clam shell, 10 parts of vinegared turmeric, 13 parts of sedge and 3 parts of duckbill flower.

[0015] Among the above drugs, Cat's Claw: Sweet, pungent, warm in nature. Enters the liver and lung meridians. Resolves phlegm and resolves stagnation, detoxifies and reduces swelling. Its pungent and dispersing nature can resolve phlegm and eliminate depression, making it a good medicine for treating scrofula, phlegm nodules, lymph node tuberculosis and other diseases.

[0016] Prunella Vulgaris: Prunella Vulgaris is pungent, bitter and cold in nature. It enters the liver and gallbladder meridians. Prunella Vulgaris is used to regulate liver problems through its bitter taste to dissipate heat, pungent taste to disperse heat and cold nature to clear fire. It can not only clear liver fire and dissipate depression, but also nourish blood and calm hyperactivity of liver yang. It is suitable for problems such as excessive liver fire, high blood pressure and nodules. It is especially suitable for nighttime eye pain caused by blood deficiency and liver heat, and is an important medicinal material for improving vision.

[0017] Gleditsia sinensis: Gleditsia sinensis is pungent and warm in nature. It enters the liver and stomach meridians. This product has the effects of reducing swelling, expelling toxins, draining pus, and killing insects. It is used for carbuncle at the beginning or pus formation without ulceration; external treatment of scabies, leprosy.

[0018] Lapis lazuli: salty, astringent, cold in nature, enters the liver, kidney, and bladder meridians. It has the effects of clearing away heat, detoxifying, and drying up yellow water.

[0019] Curcuma zedoaria with vinegar: It tastes pungent and bitter, is warm in nature, and enters the liver and spleen meridians. It has the effects of promoting qi and removing blood, eliminating accumulation and relieving pain. It can be used to treat dysmenorrhea, amenorrhea, chest pain, heart pain, masses and other symptoms caused by blood stasis and qi stagnation. It can also be used to treat swelling and pain caused by trauma, as well as stomach distension and pain, hiccups, acid reflux, poor appetite, nausea, vomiting and other discomfort symptoms caused by food accumulation and qi stagnation.

[0020] Fried Tribulus terrestris: warm in nature, pungent and bitter in taste, enters the liver meridian, has the effects of calming the liver and relieving depression, promoting blood circulation and dispelling wind, improving eyesight, and relieving itching.

[0021] Calcined clam shell: It is cold in nature, salty in taste, and belongs to the stomach meridian, kidney meridian, and lung meridian. It mainly has the effects of clearing the lungs and resolving phlegm, promoting diuresis and eliminating evil, astringing sores and removing dampness, softening and dispersing nodules, and stopping acid and relieving pain.

[0022] Vinegar Curcuma: bitter, spicy, slightly cold, enters the liver, heart, and lung meridians. It has the effects of promoting qi and blood circulation, soothing the liver and relieving depression, cooling blood and stopping bleeding, resolving phlegm and relieving cough, digesting food and removing stagnation, and promoting bile and relieving jaundice. Rabbit Ear Grass: It tastes bitter and sweet, is cold in nature, and enters the liver and lung meridians. It usually has the effects of clearing away heat and detoxifying, promoting blood circulation and regulating menstruation, activating blood circulation and cooling blood, and lowering blood pressure. It is mainly used to treat hypertension and irregular menstruation.

[0023] Adhatoda vasica: Bitter and pungent in taste, warm in nature. It acts on the lung, stomach and liver meridians. It has the effects of expelling wind and promoting blood circulation, dissipating stasis and relieving pain, setting fractured bones and reducing swelling, and detoxifying and relieving pain.

[0024] In the present invention, Ranunculus ternatus Thunb. and Prunella vulgaris L. are used together as the monarch drugs, which are pungent and bitter in flavor, and work together to achieve the effect of detoxifying and dissipating nodules. Saponaria spina-christi, Rhizoma Curcumae Aromaticae processed with vinegar, and Concha Meretricis / Cyclinae calcined are used as the ministerial drugs. Saponaria spina-christi is pungent, warm and penetrating, reducing swelling and discharging pus, assisting the monarch drugs to disperse phlegm and stasis. Rhizoma Curcumae Aromaticae processed with vinegar enhances the effects of promoting blood circulation to remove blood stasis, promoting qi movement and relieving pain, targeting the masses caused by the intermingling of phlegm and stasis. Concha Meretricis / Cyclinae calcined is salty and softens hardness, astringent and reduces phlegm, and after calcination, its astringency is enhanced to balance the pungent dispersion of the monarch drugs. Lapis lazuli, Radix Curcumae processed with vinegar, and Fructus Tribuli stir-fried are used as the adjuvant drugs, with lapis lazuli clearing heat and detoxifying, Radix Curcumae processed with vinegar soothing the liver and relieving depression, and Fructus Tribuli stir-fried soothing the liver and improving eyesight, coordinating the medicinal properties of the whole prescription. Herba Lagotis glauca and Adhatoda vasica are used as the guiding drugs. For liver and gallbladder heat, Herba Lagotis glauca helps Prunella vulgaris soothe the liver and dissipate nodules, and Adhatoda vasica helps the monarch drugs resolve phlegm and detoxify. The whole prescription together exerts the effects of soothing the liver and relieving depression, and resolving phlegm and dissipating nodules.

[0025] According to clinical needs, the composition of the present invention can be made into any pharmaceutically acceptable dosage form, including: Decoction: Put several medicinal materials into a casserole or stainless steel pot, add cold water, and the amount of added water is 5 - 8 times the total weight volume of the medicinal materials (the weight volume is calculated as g for solids and ml for liquids). Soak for 30 minutes to 1 hour to allow the medicinal materials to fully absorb water. First, bring to a boil over high heat (strong fire), and then change to low heat (gentle fire) for slow simmering. The simmering time is 30 - 40 minutes. Stir appropriately during the simmering process to prevent the medicinal materials from sticking to the bottom. Filter the medicinal liquid with a gauze or strainer to obtain the first filtrate, and pour it into a clean container; add cold water to the medicinal residues again, with the amount of added water being 2 / 3 of the first time, repeat the decoction once, change to low heat after boiling and simmer for 20 - 30 minutes, filter the medicinal liquid, mix it with the first filtrate, and then heat and concentrate the combined medicinal liquids of the two decoctions to 300 mL, filter the medicinal liquid, and the finished decoction is obtained.

[0026] Ointment: For oral administration: Decoct the Chinese medicinal materials 2 - 3 times, combine the medicinal liquids, and concentrate to a thick paste. Mix the concentrated medicinal liquid with honey, syrup, donkey-hide gelatin, deer-hide gelatin, yellow gelatin, turtle shell gelatin, deer-hide gelatin, maltose or rock sugar, stir evenly, add vegetable oil, heat to 150 - 160 °C, and remove the moisture. Pour the mixed ointment into a container, cool to room temperature to form an ointment, and put the ointment into a sealed container and store it in a cool and dry place to obtain the oral ointment; for external use: Grind the Chinese medicinal materials into fine powder, or decoct and extract the medicinal liquid, mix the medicinal powder or liquid with a matrix (such as petrolatum, beeswax), heat and stir until uniform, pour the mixed ointment into a container, cool to room temperature to form an ointment, and put the ointment into a sealed container and store it in a cool and dry place to obtain the external ointment.

[0027] Traditional Chinese Medicine Application: Grind traditional Chinese medicinal materials into fine powder, or decoct them to extract the medicinal liquid. Mix the medicinal powder or liquid with a matrix (such as honey, vinegar, wine, vaseline, etc.), stir evenly to make a paste or ointment. Evenly spread the mixed medicine on gauze or cotton cloth with appropriate thickness, and apply the dressing with the spread medicine on the affected area or specific acupoints, then fix it with adhesive tape to obtain the external application patch.

[0028] Liquor Preparation: Soak the medicinal materials in white liquor or yellow rice wine for 7 - 30 days, filter to remove the residue, and take the medicinal liquor, then the liquor preparation is obtained.

[0029] Elixir Preparation: Grind traditional Chinese medicinal materials into fine powder, sieve to ensure the powder is uniform and delicate. Mix the medicinal powder with excipients (such as vinegar, wine, honey, etc.) in proportion, stir evenly. Put the mixed medicine into a pill furnace, heat and refine it. After refining is completed, cool the medicine to form an elixir, put it into a sealed container, and store it in a cool and dry place.

[0030] Tablet Preparation: Grind traditional Chinese medicinal materials into fine powder, sieve to ensure the powder is uniform and delicate. Mix the medicinal powder with excipients (such as starch, microcrystalline cellulose, etc.) in proportion, stir evenly. Add an appropriate amount of binder (such as water, ethanol) to the mixed medicine to make wet granules, then granulate through a sieve to form uniform granules. Place the wet granules in a drying oven and dry at a low temperature (temperature not exceeding 60°C). Screen the dried granules to ensure the particle size is uniform. Add a lubricant (such as magnesium stearate) to the screened granules, mix evenly, and use a tableting machine to press the granules into tablets. Put the tablets into a sealed container and store it in a cool and dry place.

[0031] Capsule Preparation: Grind traditional Chinese medicinal materials into fine powder, sieve to ensure the powder is uniform and delicate. Mix the medicinal powder with excipients (such as starch, microcrystalline cellulose, etc.) in proportion, stir evenly. Use a capsule filling machine to fill the mixed medicine into the capsule shells, close the upper and lower parts of the capsule shells to ensure sealing. Put the capsules into a sealed container and store it in a cool and dry place.

[0032] Granule Preparation: Decoct traditional Chinese medicinal materials 2 - 3 times, combine the medicinal liquids, and concentrate them into a thick paste. Or if using medicinal powder, grind the traditional Chinese medicinal materials into fine powder. Mix the concentrated paste or medicinal powder with excipients (such as dextrin, sucrose, etc.) in proportion, stir evenly. Add an appropriate amount of binder (such as water, ethanol) to the mixed medicine to make wet granules, granulate through a sieve to form uniform granules. Place the wet granules in a dryer and dry at a low temperature (temperature not exceeding 60°C). Screen the dried granules to ensure the particle size is uniform. Put the granules into a sealed container and store it in a cool and dry place.

[0033] Usage Method: For oral administration, take it twice a day, 14 days as one course of treatment, and there are 6 courses of treatment in total. For external use, apply it once every two days, 1 month as one course of treatment, and there are 2 courses of treatment in total.

[0034] As can be seen from the above, the traditional Chinese medicine composition for treating nodular diseases with phlegm-heat accumulation in the interior is a traditional Chinese medicine composition mainly for soothing the liver and relieving depression, resolving phlegm and dissipating nodules, with the advantages of high curative effect and no toxic and side effects. The curative effect is very good through clinical experiments. Taking Example 3 as an example, the clinical data are as follows: I. Case selection: A total of 863 patients with nodular diseases admitted to the First Affiliated Hospital of Henan University of Traditional Chinese Medicine and the Third Affiliated Hospital of Henan University of Traditional Chinese Medicine from October 2015 to October 2024.

[0035] II. Treatment plan: Take it according to the above method of the finished decoction. 14 days is one course of treatment, and 6 courses of treatment are continuously used, and the curative effect is statistically analyzed.

[0036] III. Diagnostic criteria: 3.1 Evaluation method Use color Doppler ultrasound measurement (in the same hospital). Measure the change in the diameter or volume of the nodule to evaluate the curative effect.

[0037] 3.2 Curative effect judgment criteria Complete remission (CR), that is, cured: the nodule completely disappears; Partial remission (PR), that is, markedly effective: the diameter of the nodule is reduced by ≥30%; Disease stable (SD), that is, effective: the diameter of the nodule is reduced by <30% or increased by <20%; Disease progression (PD), that is, ineffective: the diameter of the nodule is increased by ≥20%, or new lesions appear.

[0038] Total effective rate = (clinical cure + marked effect + effective) / total number of cases × 100%.

[0039] V. Treatment effect: According to the curative effect evaluation criteria, after statistical processing, the results are as follows: 12 cases (1.4%) with complete remission, 445 cases (51.6%) with partial remission, 366 cases (42.4%) with disease stable, 40 cases (4.6%) with disease progression, and the total effective rate is 95.4%.

[0040] VI. Typical cases 1. Li XX, female, 59 years old, from Luoyang, Henan She was diagnosed with pulmonary nodule for more than 1 month. CT showed a nodule in the right lung with a size of 5*6mm, and occasionally had chest tightness. Treated with the medicine of the present invention, the chest tightness symptom was relieved after 1 month, and the CT was reexamined after taking the medicine for 3 months, and the size of the nodule was 3*2mm.

[0041] 2. Wang XX, female, 30 years old, from Shangqiu, Henan More than half a year after being diagnosed with a thyroid nodule, color Doppler ultrasound showed a right thyroid nodule (BI-RADS category 3). After using the drug of the present invention for 1 month and then rechecking with color Doppler ultrasound, it showed a right thyroid nodule (BI-RADS category 2).

[0042] 3. Zhao, female, 32 years old, from Zhengzhou, Henan More than 1 month after being diagnosed with a breast nodule, color Doppler ultrasound showed (BI-RADS category 2). After using the drug of the present invention, the nodule disappeared after rechecking with color Doppler ultrasound 3 months later.

[0043] VII. Conclusion In summary, the component raw materials of the present invention are rich and easily available, the compatibility is scientific and reasonable, the cost is low, and the effect is good. It has the effects of soothing the liver and relieving depression, resolving phlegm and dissipating nodules, and can be effectively used to treat nodular diseases of the type of internal accumulation of phlegm-heat, such as lung nodules, breast nodules, thyroid nodules, lymph node enlargement, etc., and significantly reduces the nodule volume. The curative effect is stable and reliable, and the effect is good. After clinical trials, the effective rate is as high as 95.4%. It is a major innovation in the drugs for treating nodular diseases of the type of internal accumulation of phlegm-heat, and can be taken for a long time to adjust the pathological state of internal accumulation of phlegm-heat in the body and reduce the probability of malignant transformation of nodules. It has great social and economic benefits.

[0044] It should be noted that the technical features and key of this application are the compatibility of the traditional Chinese medicine composition. The dosage forms given above are only partial embodiments. Any technical solutions that are essentially the same as this application made by means of equivalent substitution or various dosage forms suitable for taking prepared by using the traditional Chinese medicine composition of this application by conventional preparation methods belong to the protection scope of this application.

Claims

1. A Chinese medicine composition for treating nodular diseases of endogenous phlegm-heat type, characterized in that: The invention comprises the following raw materials in parts by weight: 5-50 parts of cat's claw, 5-60 parts of selfheal, 3-40 parts of thorns of honey locust, 1-5 parts of lapis lazuli, 3-20 parts of vinegared zedoaria, 3-30 parts of stir-fried tribulus terrestris, 5-40 parts of calcined clam shell, 4-30 parts of vinegared turmeric, 1-15 parts of rabbit ear grass and 1-5 parts of duckbill flower.

2. The Chinese medicine composition for treating nodular diseases of phlegm-heat internal accumulation type according to claim 1, characterized in that: The invention comprises the following raw materials in parts by weight: 5 parts of cat's claw, 5 parts of selfheal, 3 parts of thorns of Gleditsia sinensis, 1 part of lapis lazuli, 3 parts of vinegared zedoaria, 3 parts of stir-fried tribulus terrestris, 5 parts of calcined clam shells, 4 parts of vinegared turmeric, 1 part of rabbit ear grass and 1 part of duckbill flower.

3. The Chinese medicine composition for treating nodular diseases of endogenous phlegm-heat type according to claim 1, characterized in that: The invention comprises the following raw materials in parts by weight: 50 parts of cat's claw, 60 parts of selfheal, 40 parts of thorns of Gleditsia sinensis, 5 parts of lapis lazuli, 20 parts of vinegared zedoaria, 30 parts of stir-fried tribulus terrestris, 40 parts of calcined clam shells, 30 parts of vinegared turmeric, 15 parts of rabbit ear grass and 5 parts of duckbill flower.

4. The Chinese medicine composition for treating nodular diseases of phlegm-heat internal accumulation type according to claim 1, characterized in that: The invention comprises the following raw materials in parts by weight: 27 parts of cat's claw, 32 parts of selfheal, 21 parts of thorns of Gleditsia sinensis, 3 parts of lapis lazuli, 11 parts of vinegared zedoaria, 16 parts of stir-fried tribulus terrestris, 22 parts of calcined clam shells, 17 parts of vinegared turmeric, 8 parts of rabbit ear grass and 3 parts of duckbill flower.

5. The Chinese medicine composition for treating nodular diseases of endogenous phlegm-heat type according to claim 1, characterized in that: The invention comprises the following raw materials in parts by weight: 10 parts of cat's claw, 50 parts of selfheal, 30 parts of thorns of honey locust, 2 parts of lapis lazuli, 18 parts of vinegared zedoaria, 10 parts of stir-fried tribulus terrestris, 15 parts of calcined clam shells, 25 parts of vinegared turmeric, 5 parts of rabbit ear grass and 2 parts of duckbill flower.

6. The Chinese medicine composition for treating nodular diseases of phlegm-heat internal accumulation type according to claim 1, characterized in that: The invention comprises the following raw materials in parts by weight: 40 parts of cat's claw, 10 parts of selfheal, 10 parts of thorns of Gleditsia sinensis, 4 parts of lapis lazuli, 7 parts of vinegared zedoaria, 20 parts of stir-fried tribulus terrestris, 10 parts of calcined clam shells, 10 parts of vinegared turmeric, 13 parts of rabbit ear grass and 3 parts of duckbill flower.

7. Use of the traditional Chinese medicine composition for treating nodular diseases of internal phlegm-heat type according to any one of claims 1 to 6 in the preparation of drugs for treating nodular diseases of internal phlegm-heat type.

8. The use according to claim 7, characterized in that: The medicine is selected from decoction, ointment, patch, wine, pill, tablet, capsule or granule.