Preparation process and application of qi and blood tonifying composition

Abstract

The invention discloses a qi and blood tonifying composition as well as a preparation process and application thereof, and belongs to the field of health care products. The composition for tonifying qi and blood provided by the invention takes the perilla leaf powder, the eclipta alba powder, the asparagus cochinchinensis powder, the hen egg membrane powder, the husked sorghum powder and the ginger powder as raw materials, and an excellent effect of tonifying qi and blood is obtained by compounding the raw materials.

Description

Technical Field

[0001] The present invention relates to the field of health products, and specifically relates to a preparation process and application of a qi and blood supplement composition. Background Art

[0002] In modern society, with the acceleration of the pace of life, people are facing various pressures and challenges. Often in a high-intensity working state and a fast-paced lifestyle, over time, these lifestyles have an adverse impact on the body, and some people gradually show a series of sub-healthy phenomena such as qi deficiency and fatigue, and deficiency of yin and blood. Qi deficiency and fatigue are manifested as easy fatigue, listlessness, decreased physical strength, and shortness of breath even with a little activity; deficiency of yin and blood may lead to symptoms such as pale complexion, dizziness, insomnia, and forgetfulness. These health problems not only affect daily life and work efficiency but also attract wide attention from all sectors of society.

[0003] Based on the above background, there is an urgent need to develop a product that can play a certain role in replenishing qi and blood to help young people improve their physical condition, enhance their physique, and improve their quality of life. Summary of the Invention

[0004] The purpose of the present invention is to provide a preparation process and application of a qi and blood supplement composition. The qi and blood supplement composition uses perilla leaf powder, eclipta prostrata powder, asparagus root powder, egg membrane of chicken powder, job's tears powder, and ginger powder as raw materials, and excellent qi and blood supplement effects are obtained through compounding the above raw materials.

[0005] In order to achieve the above purpose, the present invention adopts the following technical solutions:

[0006] In the first aspect, the present invention provides a qi and blood supplement composition, and the qi and blood supplement composition includes the following raw materials in parts by mass:

[0007] Perilla leaf powder: 5 - 7 parts;

[0008] Eclipta prostrata powder: 5 - 7 parts;

[0009] Asparagus root powder: 5 - 7 parts;

[0010] Egg membrane of chicken powder: 5 - 7 parts;

[0011] Job's tears powder: 2 - 4 parts;

[0012] Ginger powder: 2 - 4 parts.

[0013] Further, the qi and blood supplement composition includes the following raw materials in parts by mass:

[0014] Perilla leaf powder: 6 parts;

[0015] Eclipta prostrata powder: 6 parts;

[0016] Asparagus root powder: 6 parts;

[0017] Membrane of chicken embryo egg powder: 6 parts;

[0018] Sorghum powder: 3 parts;

[0019] Ginger powder: 3 parts.

[0020] In a second aspect, the present invention provides the use of the qi and blood tonifying composition described in the first aspect in the preparation of a qi and blood tonifying preparation.

[0021] Preferably, the qi and blood tonifying preparation is a qi and blood tonifying powder or a qi and blood tonifying concentrated liquid.

[0022] In a third aspect, the present invention provides the qi and blood tonifying concentrated liquid described in the second aspect. The preparation method of the qi and blood tonifying concentrated liquid comprises the following steps:

[0023] Mix the qi and blood tonifying composition described in the first aspect with drinking water and soak. After the soaking is completed, decoct to obtain a decoction; concentrate the decoction to 1 / 4 - 1 / 6 of the original volume to obtain the qi and blood tonifying concentrated liquid;

[0024] In the preparation method, the mass ratio of the qi and blood tonifying composition to drinking water is 1:5 - 8; the soaking time is 0.5 - 1.5 h; the decocting time is 4 - 8 h; the decocting temperature is 60 - 80 °C.

[0025] Compared with the prior art, the beneficial effects of the present invention are as follows: The present invention provides a qi and blood tonifying composition, which is prepared from perilla leaf powder, eclipta powder, asparagus powder, membrane of chicken embryo egg powder, sorghum powder, and ginger powder. Through research, it is found that there is a synergistic effect among perilla leaf powder, eclipta powder, asparagus powder, membrane of chicken embryo egg powder, sorghum powder, and ginger powder in the present invention. Specifically:

[0026] Perilla leaf powder has dual effects of hemostasis and anticoagulation. Among them, terpenoid compounds such as perillaldehyde have anti-inflammatory and antioxidant effects, which can improve blood circulation and promote the generation of qi and blood. Eclipta prostrata powder has the effects of cooling blood to stop bleeding and enhancing coagulation ability. The various flavonoids and polyphenols contained in it can promote blood circulation and the generation of qi and blood through antioxidant and immune regulation. Asparagus root powder contains components such as flavonoids, polysaccharides, and steroidal saponins, and has the effects of nourishing yin and moistening dryness, supplementing qi and nourishing blood. Its polysaccharide component can regulate immune function and enhance hematopoietic function, thus playing a role in supplementing qi and blood. Membrane of chicken's eggshell membrane powder contains rich active substances, which can promote blood circulation, increase the synthesis of hemoglobin, improve the oxygen supply capacity of blood, thus improving anemia symptoms and playing a role in supplementing qi and blood. Sorghum powder is rich in dietary fiber and various trace elements, which can regulate gastrointestinal function, promote nutrient absorption, and indirectly provide a material basis for the generation of qi and blood. Ginger powder has the effects of warming the middle-jiao to dispel cold and promoting blood circulation. Its components can stimulate blood vessel dilation and promote blood flow, thus enhancing the circulation of qi and blood. Among them, asparagus root powder and membrane of chicken's eggshell membrane powder have the effect of supplementing qi and blood, can regulate immunity and promote hematopoietic function, increase the synthesis of hemoglobin, and play a role in supplementing qi and nourishing blood. Ginger powder, by warming the middle-jiao to dispel cold, promoting blood circulation, and enhancing the circulation of qi and blood, acts synergistically with asparagus root powder and membrane of chicken's eggshell membrane powder to further enhance the effect of supplementing qi and blood. Perilla leaf powder and eclipta prostrata powder have dual effects of hemostasis and anticoagulation. Perilla leaf powder can regulate the balance of blood coagulation and anticoagulation, while eclipta prostrata powder can promote wound healing by enhancing coagulation ability. The combination of perilla leaf powder and eclipta prostrata powder can not only effectively stop bleeding but also avoid blood stasis and promote qi and blood circulation. Sorghum powder can regulate gastrointestinal function, promote nutrient absorption, and provide a material basis for the generation of qi and blood. The effect of ginger powder in warming the middle-jiao to dispel cold can improve the function of the digestive system and further promote nutrient absorption. The two act synergistically to provide sufficient nutritional support for the generation of qi and blood. The polysaccharides and flavonoid components in asparagus root powder and eclipta prostrata powder have immune regulation and antioxidant effects, can enhance the body's immunity, scavenge free radicals, protect cells from oxidative damage, and thus create a good internal environment for the generation of qi and blood. In summary, the six compositions in the present invention, through their respective action mechanisms, synergistically interact with each other in supplementing qi and blood, and jointly play multiple effects such as promoting blood circulation, enhancing hematopoietic function, regulating immunity, and improving nutrient absorption, so as to achieve the effect of supplementing qi and blood. Detailed implementation manners

[0027] To better understand the present invention, the following further describes the present invention in combination with specific application examples. The terms used in the compositions are for describing specific specific implementation manners and do not constitute a limitation on the protection scope of the present invention.

[0028] The test methods without specific conditions indicated in the following tests are usually carried out under conventional conditions or according to the conditions recommended by the manufacturers. Unless otherwise specified, calculations are made according to mass percentages and mass parts.

[0029] The partial raw materials and their sources are as follows:

[0030] Perilla leaf: Purchased from Bozhou Huozhengtang Pharmaceutical Co., Ltd.;

[0031] Eclipta prostrata: Purchased from Bozhou Huozhengtang Pharmaceutical Co., Ltd.;

[0032] Asparagus root: Purchased from Gansu Yishengxiang Biotechnology Co., Ltd.;

[0033] Membrane of chicken's egg: Purchased from Gansu Yishengxiang Biotechnology Co., Ltd.;

[0034] Sorghum rice: Purchased from Bozhou Wufang Jiuru Pharmaceutical Co., Ltd.;

[0035] Ginger: Purchased from Guangzhou Huayu Biotechnology Co., Ltd.;

[0036] Before use, the above raw materials need to be impurity-removed, ground into powder, sieved through an 80-mesh sieve, and then sealed and stored for standby.

[0037] Other raw materials are all purchased commercially.

[0038] The raw materials of the qi and blood tonifying composition and their mass parts ratio are as follows:

[0039] Composition 1: Perilla leaf powder: 6 parts; Eclipta prostrata powder: 6 parts; Asparagus root powder: 6 parts; Membrane of chicken's egg powder: 6 parts; Sorghum rice powder: 3 parts; Ginger powder: 3 parts.

[0040] Composition 2: Perilla leaf powder: 5 parts; Eclipta prostrata powder: 7 parts; Asparagus root powder: 5 parts; Membrane of chicken's egg powder: 7 parts; Sorghum rice powder: 4 parts; Ginger powder: 2 parts.

[0041] Composition 3: Perilla leaf powder: 7 parts; Eclipta prostrata powder: 5 parts; Asparagus root powder: 7 parts; Membrane of chicken's egg powder: 5 parts; Sorghum rice powder: 2 parts; Ginger powder: 4 parts.

[0042] Composition ①: Different from Composition 1, it lacks Perilla leaf powder, and the lacking amount is supplemented with Eclipta prostrata powder, Asparagus root powder, Membrane of chicken's egg powder, Sorghum rice powder, and Ginger powder in a mass ratio of 6:6:6:3:3.

[0043] Composition ②: Different from Composition 1, it lacks Eclipta prostrata powder, and the lacking amount is supplemented with Perilla leaf powder, Asparagus root powder, Membrane of chicken's egg powder, Sorghum rice powder, and Ginger powder in a mass ratio of 6:6:6:3:3.

[0044] Composition ③: Different from Composition 1, it lacks Asparagus root powder, and the lacking amount is supplemented with Perilla leaf powder, Eclipta prostrata powder, Membrane of chicken's egg powder, Sorghum rice powder, and Ginger powder in a mass ratio of 6:6:6:3:3.

[0045] Composition ④: Different from Composition 1, it lacks the powder of chicken's egg membrane, and the lacking amount is supplemented with perilla leaf powder, Eclipta prostrata powder, asparagus powder, Job's tears powder, and ginger powder in a mass ratio of 6:6:6:3:3.

[0046] Composition ⑤: Different from Composition 1, it lacks Job's tears powder, and the lacking amount is supplemented with perilla leaf powder, Eclipta prostrata powder, asparagus powder, chicken's egg membrane powder, and ginger powder in a mass ratio of 6:6:6:6:3.

[0047] Composition ⑥: Different from Composition 1, it lacks ginger powder, and the lacking amount is supplemented with perilla leaf powder, Eclipta prostrata powder, asparagus powder, chicken's egg membrane powder, and Job's tears powder in a mass ratio of 6:6:6:6:3.

[0048] Composition ⑦: Perilla leaf powder: 4 parts; Eclipta prostrata powder: 8 parts; Asparagus powder: 4 parts; Chicken's egg membrane powder: 8 parts; Job's tears powder: 5 parts; Ginger powder: 1 part.

[0049] Qi and Blood Tonifying Concentrate 1 - 3, ① - ⑦: The compositions used are Composition 1 - 3, ① - ⑦, and their preparation methods are as follows:

[0050] Mix the qi and blood tonifying composition and drinking water in a mass ratio of 1:7, soak for 1 h, and decoct at 70 °C for 6 h to obtain a decoction; concentrate the decoction to 1 / 5 of its original volume to obtain the qi and blood tonifying concentrate.

[0051] Qi and Blood Tonifying Concentrate 4: The composition used is Composition 1, and its preparation method is as follows:

[0052] Mix the qi and blood tonifying composition and drinking water in a mass ratio of 1:5, soak for 1.5 h, and decoct at 60 °C for 8 h to obtain a decoction; concentrate the decoction to 1 / 4 of its original volume to obtain the qi and blood tonifying concentrate.

[0053] Qi and Blood Tonifying Concentrate 5: The composition used is Composition 1, and its preparation method is as follows:

[0054] Mix the qi and blood tonifying composition and drinking water in a mass ratio of 1:8, soak for 0.5 h, and decoct at 80 °C for 4 h to obtain a decoction; concentrate the decoction to 1 / 6 of its original volume to obtain the qi and blood tonifying concentrate.

[0055] Qi and Blood Tonifying Concentrate ⑧: The composition used is Composition 1, and its preparation method is as follows:

[0056] Mix the qi and blood tonifying composition and drinking water in a mass ratio of 1:7, without soaking, directly decoct at 70 °C for 7 h to obtain a decoction; concentrate the decoction to 1 / 5 of its original volume to obtain the qi and blood tonifying concentrate.

[0057] Qi and Blood Tonifying Concentrate ⑨: The composition used is Composition 1, and its preparation method is as follows:

[0058] The qi and blood tonifying composition and drinking water are mixed and soaked at a mass ratio of 1:7 for 1 h, and then decocted at 100 °C for 6 h to obtain a decoction; the decoction is concentrated to 1 / 5 of the original volume to obtain the concentrated qi and blood tonifying liquid.

[0059] Evaluation of the efficacy of qi and blood tonifying:

[0060] Test samples: Concentrated qi and blood tonifying liquids 1-5, ①-⑨.

[0061] Configuration of test samples: The test samples are diluted with drinking water to a 30 v / v% mixture, and prepared immediately before use.

[0062] Experimental animals: 200 male SPF-grade mice at 7 weeks of age are taken and raised in a controllable environment, with a 12-h day-night cycle, a temperature of 22 ± 2 °C, a humidity of 50 ± 5%, and a closed space. The mice can freely eat and drink water.

[0063] Grouping of animals: The experimental animals are randomly selected and randomly divided into 16 groups, including 1 normal control group, 1 model control group, and 14 test groups; there are 9 mice in each group.

[0064] Experimental method:

[0065] Medication starts on the 1st day from the beginning of the experiment, and the administration mode is gavage. The test groups are gavaged with the test samples at a gavage concentration of 0.1 mL / 10 g body weight; the normal control group and the model control group are gavaged with drinking water, and the gavage dose is the same as that of the test groups. The test groups, the normal control group, and the model control group are continuously gavaged for 28 days.

[0066] The model control group and the test groups are subcutaneously injected with phenylhydrazine hydrochloride at a dose of 20 mg / kg once on the 2nd day from the beginning of the experiment; on the 5th day from the beginning of the experiment, they are subcutaneously injected with phenylhydrazine hydrochloride at a dose of 40 mg / kg once; on the 5th, 6th, 7th, and 8th days from the beginning of the experiment, they are intraperitoneally injected with cyclophosphamide at a dose of 40 mg / kg once a day for the above four days. The normal group is injected with normal saline at the same time, in the same dose, and at the same site.

[0067] After the 28th day, the whole blood from the mouse tail tip is taken, and the white blood cell count (WBC), red blood cell count (RBC), hemoglobin (HGB), and platelet count (PLT) results are measured by an automatic three-part blood analyzer.

[0068] Experimental results:

[0069] The measured results of WBC, RBC, HGB, and PLT in the blood of mice in each group are shown in Table 1.

[0070] Table 1 Measured results of mouse blood

[0071]

[0072]

[0073] Note: "*" indicates comparison with the normal control group, p < 0.05; "#" indicates comparison with the model control group, p < 0.05.

[0074] It can be seen from the results in Table 1 that:

[0075] The Qi and Blood Tonifying Concentrates 1 - 5 all have varying degrees of improvement on the blood indexes of mice, among which the Qi and Blood Tonifying Concentrate 1 has a relatively significant improvement.

[0076] By comparing the results of Qi and Blood Tonifying Concentrate 1 with those of Qi and Blood Tonifying Concentrates ① - ⑦, it can be seen that there is a significant synergistic effect among the various raw materials in the composition defined by the present invention.

[0077] By comparing the results of Qi and Blood Tonifying Concentrate 1 with those of Qi and Blood Tonifying Concentrates ⑧ - ⑨, it can be seen that within the range of the preparation process and parameters defined by the present invention, the Qi and Blood Tonifying effect of the Qi and Blood Tonifying Concentrate on mice can be effectively improved.

[0078] Application Example 1:

[0079] A beverage for tonifying Qi and nourishing blood, the components and mass percentages thereof are specifically as follows:

[0080] Qi and Blood Tonifying Concentrate 1: 30%;

[0081] Drinking water: 70%;

[0082] Preparation method: Stir Qi and Blood Tonifying Concentrate 1 and drinking water evenly, fill into containers, sterilize, and store in a sealed manner.

[0083] Sensory evaluation:

[0084] According to the detection methods and sensory requirements described in GB7101 - 2022 "National Food Safety Standard Beverages", 10 professionally trained sensory evaluators were selected to evaluate Application Example 1 of the present invention.

[0085] Evaluation result: The beverage for tonifying blood and Qi prepared in Application Example 1 of the present invention has uniform color, has the color that the product should have, has a slightly sweet taste, has the unique fragrance of plants, has no abnormal odor, has a uniform state, and has no foreign matter visible to normal vision.

[0086] The embodiments described above are some, but not all, of the embodiments of the present invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the claimed invention, but merely represents selected embodiments of the present invention. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without creative efforts fall within the scope of protection of the present invention.

Claims

1. A Qi and blood replenishing composition, characterized in that: Contains the following raw materials by weight: Perilla leaf powder: 5-7 parts; Eclipta prostrata powder: 5-7 parts; Asparagus powder: 5-7 portions; Phoenix clothing powder: 5-7 parts; Millet flour: 2-4 portions; Ginger powder: 2-4 servings.

2. The composition according to claim 1, characterized in that Contains the following raw materials by weight: Perilla leaf powder: 6 parts; Eclipta prostrata powder: 6 parts; Asparagus powder: 6 portions; Phoenix clothing powder: 6 parts; Millet flour: 3 portions; Ginger powder: 3 parts.

3. Use of the composition according to claim 1 or 2 in the preparation of a Qi and blood tonifying preparation.

4. The use according to claim 3, characterized in that: The Qi and blood replenishing preparation is a Qi and blood replenishing powder or a Qi and blood replenishing concentrated liquid.

5. A concentrated solution for replenishing qi and blood as claimed in claim 4, characterized in that: The preparation method of the concentrated solution comprises the following steps: The qi and blood replenishing composition according to claim 1 or 2 is mixed with drinking water and soaked, and then boiled after soaking to obtain a decoction; the decoction is concentrated to 1 / 4-1 / 6 of the original volume to obtain the qi and blood replenishing concentrated solution.

6. The Qi-replenishing and blood-replenishing concentrated solution according to claim 5, characterized in that: The mass ratio of the qi and blood replenishing composition to drinking water is 1:5-8.

7. The Qi-replenishing and blood-replenishing concentrated solution according to claim 5, characterized in that: The soaking time is 0.5-1.5h.

8. The Qi-replenishing and blood-replenishing concentrated solution according to claim 5, characterized in that: The decoction time is 4-8h.

9. The Qi-replenishing and blood-replenishing concentrated solution according to claim 5, characterized in that: The decoction temperature is 60-80℃.

10. A product for replenishing qi and blood, characterized in that: It comprises the Qi and blood replenishing composition described in any one of claims 1-2 or the Qi and blood replenishing concentrated solution described in any one of claims 5-9.

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