Long-tube atomizing dosing device

Abstract

The invention provides a long-tube atomization dosing device which comprises an atomization dosing hose with the length larger than 200 mm, the atomization dosing hose comprises an airflow cavity and a liquid medicine cavity, and the area of an air spraying hole in the head end of the airflow cavity is not larger than 0.3 times of the cross section of the airflow cavity; a medicine outlet hole in the head end of the liquid medicine cavity is formed in the edge of the air injection hole; an included angle of 45-90 degrees is formed between the medicine outlet hole and the central axis of the air injection hole; the tail end of the airflow cavity is communicated with an air supply device, and the tail end of the liquid medicine cavity is communicated with a dosing device; pressurized air flow of the air supply device is sprayed out from the narrow air spraying hole through the air flow cavity, negative pressure is generated in the air spraying hole, liquid medicine discharged from the medicine outlet hole through the liquid medicine cavity by the dosing device is sucked into the air flow and blown into mist, and the air flow is used for conducting atomization dosing on the deep part of a body cavity through a medical endoscope operation cavity or is directly placed into the human body cavity. The oral-nasal aerosol inhalation device is simple in structure, low in cost, accurate in administration, uniform, rapid, safe and reliable.

Description

Technical Field

[0001] The present invention relates to the field of medical devices, and particularly to a long-tube atomizing drug delivery device. Background Art

[0002] During endoscopy, it is often necessary to locally atomize and administer drugs (porphyrin drugs or fluorescein) to body cavities (digestive tract, airway) to perform fluorescence endoscopy, which is convenient for early detection of microtumors and precancerous lesions that cannot be diagnosed by conventional endoscopy, guiding accurate biopsy, differentiating and diagnosing certain conditions, accurately positioning the boundary of tumors, judging the resection range and tumor killing effect, etc.

[0003] Currently, most of the fluorescent agents for endoscopy are administered by injection and spraying. The drug administration is uneven and the dosage is large, which not only affects the clinical effect but also has a harmful effect on the human body. If an atomizer is connected to the end of the endoscopy channel for drug administration, most of the atomized medicine forms condensate beads on the inner wall when passing through the narrow endoscopy channel, and the effect is extremely poor.

[0004] To achieve fluorescence examination of the bronchoscope, aerosol inhalation of the fluorescent agent is often carried out before the examination, which takes about half an hour. The dose of the fluorescent agent is large, and all respiratory tracts and alveoli are in contact with the fluorescent agent, which brings harm to the patient and inconvenience to the clinic.

[0005] Clinically, there is an urgent need for a device that can be inserted through the endoscopy channel, and after exiting the endoscopy channel, can atomize and evenly administer drugs locally on the inner wall of the body cavity to be examined, reduce the dosage of the fluorescent agent, and facilitate temporary implementation.

[0006] At the same time, in the anesthesiology department or the intensive care unit (ICU), patients with tracheal intubation often suffer from respiratory or pulmonary diseases and need atomized drug treatment. When atomizing and administering drugs, the atomizer is at the connection part of the tracheal catheter and the breathing corrugated tube. The atomized drug enters the respiratory system through the tracheal catheter. Under the influence of the patient's breathing airflow, a large amount of the atomized drug adheres to the inner wall of the tracheal catheter and the large airway, and it is difficult to enter the deep part of the lung, resulting in drug waste and poor effect. Clinically, there is also an urgent need for a device that can directly atomize and administer drugs deep in the airway, increase the dosage of the drug entering the small airway and alveoli, reduce drug waste caused by breathing, and improve the treatment effect.

[0007] At the same time, currently, whether it is a medical or household atomizer, when a non-intubated conscious patient undergoes aerosol inhalation treatment, the liquid medicine tank at the inhalation end of the aerosol treatment must be upright, and the patient must be in a standing or sitting position to perform aerosol inhalation, and it cannot be carried out in a lying position. This is extremely inconvenient for critically ill elderly patients, comatose patients, and uncooperative infants, causing burden and discomfort to the patients. Clinically, there is an urgent need for a device that has no position restriction on the patient and can easily achieve aerosol inhalation treatment even when the patient is in a supine position, which is convenient for elderly patients, comatose patients to perform aerosol inhalation treatment in the lying position and for infants to perform aerosol inhalation treatment in the sleeping state. Summary of the Invention

[0008] In view of the above-mentioned defects of the prior art, the present invention provides a long-tube atomizing drug dispenser, which includes an atomizing drug delivery hose with a length greater than 200 mm. The atomizing drug delivery hose includes an air flow chamber and a liquid medicine chamber. An air jet hole is provided at the head end of the air flow chamber, and the area of the air jet hole is not greater than 0.3 times the cross-sectional area of the air flow chamber.

[0009] An outlet hole is provided at the head end of the liquid medicine chamber, and the outlet hole is arranged at the edge of the air jet hole; the outlet hole forms an angle of 45-90° with the central axis of the air jet hole.

[0010] At the tail of the atomizing drug delivery hose, a gas supply device is connected to the air flow chamber, and a drug dispenser is connected to the liquid medicine chamber.

[0011] The pressurized air flow of the gas supply device is ejected through the narrow air jet hole in the air flow chamber, generating a negative pressure at the air jet hole, sucking the liquid medicine discharged from the drug dispenser through the liquid medicine chamber into the air flow at the outlet hole and dispersing it into a mist.

[0012] Further, the atomizing drug delivery hose is a single-tube double-chamber structure, with the main chamber being the air flow chamber and the secondary chamber being the liquid medicine chamber; the head end of the atomizing drug delivery hose is closed to form a blind end, and an air jet hole is provided in the liquid medicine chamber that penetrates the side wall of the atomizing drug delivery hose adjacent to the blind end. The opening of the liquid medicine chamber penetrated by the air jet hole 13 forms an outlet hole; a 120-180° corner is provided at a distance of 5-15 mm from the tail side of the air jet hole and bends away.

[0013] Further, the atomizing drug delivery hose is a double-tube structure, with the main tube being the air flow chamber and the secondary tube being the liquid medicine chamber.

[0014] A medicine spraying pipe head is hermetically connected and arranged at the head end of the air flow chamber, and the head side port of the medicine spraying pipe head forms an air jet hole; an outlet hole is arranged at the edge of the air jet hole communicating with the liquid medicine chamber.

[0015] Further, a control switch is provided in the liquid medicine chamber; the control switch is linked with the air flow chamber; when the air flow chamber pressurizes and supplies air, the control switch opens, and the liquid medicine chamber is communicated; when the air flow chamber stops supplying air, the control switch closes, and the liquid medicine chamber is blocked.

[0016] Further, the control switch includes a bladder cavity communicated with the air flow chamber, a control rod is arranged adjacent to the bladder cavity and penetrates the liquid medicine chamber, a medicine passing hole is correspondingly arranged on the control rod and the liquid medicine chamber, and an elastic body is sleeved outside the control rod.

[0017] When the pressure in the air flow chamber increases, the bladder cavity expands, pushing the control rod to shift, and the medicine passing hole is aligned with the liquid medicine chamber; when the pressure in the air flow chamber decreases, the bladder cavity returns to its original state, the elastic body elastically resets, pushing the control rod to reset, and the medicine passing hole is misaligned with the liquid medicine chamber to block it.

[0018] Further, the length of the atomizing drug delivery hose is 400-1000 mm, and the outer diameter is set to 1.5-1.8 mm or 2.5-2.8 mm.

[0019] The air supply device and the medicator are integrally arranged as a double-chamber syringe. The double-chamber syringe includes an air injection chamber and a medicine injection chamber. The cross-sectional ratio of the air injection chamber to the medicine injection chamber is greater than 5. The push rods and pistons of the air injection chamber and the medicine injection chamber are integrally linked.

[0020] Further, the length of the atomizing medicine delivery hose is 800 - 3000 mm, and the outer diameter is set to 15 - 40 mm.

[0021] The air supply device includes an air pump and a medical oxygen source. The medicator is set as an automatic medicator, including an elastic medicine bag, a medicine injection micropump, and a hanging medicine bag.

[0022] A perforated face mask or a mouthpiece tube is connected and arranged at the head end of the atomizing medicine delivery hose.

[0023] Further, the length of the atomizing medicine delivery hose is 300 - 500 mm, and the outer diameter is set to 1.5 - 4 mm.

[0024] The tail of the atomizing medicine delivery hose is movably provided with an adapter tee. The adapter tee is connected and provided with a catheter interface, a loop interface, and an atomizing insertion port. The catheter interface is adapted to the respiratory interface of the tracheal catheter. The loop interface is adapted to the threaded tube interface. The atomizing insertion port is hermetically adapted to the outer diameter of the atomizing medicine delivery hose.

[0025] The air supply device includes an air pump and a medical oxygen source. The medicator is set as an automatic medicator, including an elastic medicine bag, a medicine injection micropump, and a hanging medicine bag.

[0026] Further, the air pump is electrically connected with a chip to accurately control the power of the air pump. A gas filter is arranged at the air inlet of the air pump.

[0027] Further, several three-way tubular adjusting accessories are provided at the head of the medicine spraying tube. The adjusting accessories are provided with secondary spraying holes through the long axis, and secondary medicine outlet holes are connected to the secondary spraying holes through one side wall of the adjusting accessories.

[0028] The shape of the adjusting accessory matches the spraying hole of the head of the medicine spraying tube. The secondary spraying hole is smaller than the spraying hole, and the secondary medicine outlet hole is smaller than the medicine outlet hole.

[0029] The adjusting accessory is hermetically assembled in the spraying hole. The secondary spraying hole is hermetically connected to the spraying hole. At the same time, the secondary medicine outlet hole is hermetically connected to the medicine outlet hole.

[0030] The beneficial effects of the present invention:

[0031] 1. Through the unique structure setting of the atomizing hose, the liquid medicine container is separated from the atomizing liquid medicine outlet, so that the outer diameter of the entire atomizing pipeline is smaller, realizing tail-end medicine delivery of the atomizing hose and atomization at the head end of the atomizing hose, realizing atomizing medicine delivery for patients in any position, avoiding condensation of the atomizing liquid medicine during long-tube transmission, and realizing atomizing medicine delivery to the deep part of the body cavity.

[0032] 2. The outer diameter of the drug delivery tube is narrow, enabling convenient local atomized drug delivery through the endoscopic examination cavity; the drug delivery is uniform, the drug delivery site is precise, the drug dosage is small, and it is convenient to achieve fluoroscopy, improving the examination effect and reducing the drug dosage.

[0033] 3. It is convenient for tracheal intubation patients to administer drugs deep into the airway, improving the accuracy of the drug delivery site, reducing drug waste, and enhancing the effect of aerosol inhalation therapy.

[0034] 4. It is convenient for unconscious patients to receive aerosol inhalation drug delivery in any position (supine or semi-sitting position); and for uncooperative infants to receive aerosol inhalation therapy during sleep.

[0035] 5. The spray hole forms negative pressure, which can suck out all the liquid medicine for atomization, avoiding the waste of residual liquid medicine.

[0036] 6. The structure is simple, the cost is low, the pipeline is for single use, avoiding cross-infection, and it is easy to promote. BRIEF DESCRIPTION OF THE DRAWINGS

[0037] Figure 1 It is a schematic structural diagram of the first embodiment of the present invention;

[0038] Figure 2 It is a schematic structural diagram of the second embodiment of the present invention;

[0039] Figure 3 It is a schematic structural diagram of the third embodiment of the present invention;

[0040] Figure 4 It is a schematic structural diagram of the fourth embodiment of the present invention;

[0041] Figure 5 It is a schematic structural diagram of the fifth embodiment of the present invention;

[0042] Figure 6 It is a schematic structural diagram of a structure in which a control switch is provided in the liquid medicine cavity of the present invention;

[0043] Figure 7 It is a schematic structural diagram of an adjustment accessory of the present invention;

[0044] In the figure,

[0045] 1. Atomized drug delivery hose; 11. Air flow cavity; 12. Liquid medicine cavity; 13. Spray hole; 14. Medicine outlet hole; 15. Spray tube head; 16. Bladder cavity; 17. Control rod; 18. Medicine passage hole; 19. Elastic body; 2. Gas supply device; 21. Air pump; 22. Medical oxygen source; 23. Gas filter; 3. Drug delivery device; 31. Double-chamber syringe; 32. Air injection cavity; 33. Drug injection cavity; 34. Push rod piston; 4. Connecting tee; 41. Catheter interface; 42. Circuit interface; 43. Atomization inlet; 5. Adjustment accessory; 51. Sub-spray hole; 52. Sub-medicine outlet hole. Detailed implementation mode

[0046] In order to enable those skilled in the art to better understand the technical solutions of the present invention and make the above features, objectives and advantages of the present invention clearer and easier to understand, the present invention will be further described below in conjunction with embodiments. The embodiments are only used to illustrate the present invention and not to limit the scope of the present invention.

[0047] At present, in all clinical atomization inhalation devices, the atomization medicine outlet and the atomization liquid bottle are adjacently arranged, and the following defects exist:

[0048] 1. The atomization liquid bottle must be adjacently arranged at the mouth and nose part of the patient, so that the atomization medicine outlet is adjacent to the mouth and nose part of the patient, to avoid a large amount of condensation of the atomized medicine on the inner wall of the inhalation pipeline and affect the atomization treatment effect;

[0049] 2. The atomization liquid bottle must be kept upright, otherwise the medicine will spill, which means that the patient must keep standing or sitting; when it is necessary to perform atomization treatment on a lying patient, a section of transition pipeline must be set in front of the atomization medicine outlet. At this time, it is inevitable that the atomized medicine condenses on the inner wall of the pipeline;

[0050] 3. The atomization medicine outlet and the atomization liquid bottle are adjacent, and the overall shape is large, and it cannot enter the narrow body cavity, and can only perform atomization inhalation treatment outside the mouth and nose; when local atomization drug delivery to the body cavity is required, only atomization drug delivery to the entire respiratory system can be performed, which not only wastes drugs but also affects the treatment effect.

[0051] The present invention adopts the soft long tube head-end jet atomization technology. The medicine liquid and the air flow are both supplied from the tail of the long tube, and atomization drug delivery is performed at the head end of the soft long tube. Different thicknesses of the long tube are applied to different scenarios. Its principle is that under the Bernoulli principle, when the air flow passes through the long tube and sprays out at the narrow spray port, a negative pressure is formed locally at the spray port, sucking the medicine liquid supplied at the spray port part into the spray air flow and colliding and dispersing into aerosol particles. The size of the aerosol particles is related to the gas flow rate, the size of the narrow spray port and the medicine liquid flow rate. The size of the aerosol particles can be controlled within 0.5 - 10 microns.

[0052] As Figures 1-5 shown, the long tube atomization drug delivery device of the present invention includes an atomization drug delivery hose 1 with a length greater than 200 mm. The atomization drug delivery hose 1 includes an air flow cavity 11 and a medicine liquid cavity 12. A spray hole 13 is provided at the head end of the air flow cavity 11, and the area of the spray hole 13 is not greater than 0.3 times the cross-sectional area of the air flow cavity 11.

[0053] An outlet hole 14 is provided at the head end of the medicine liquid cavity 12. The outlet hole 14 is provided at the edge of the spray hole 13; the outlet hole 14 forms an angle of 45 - 90° with the central axis of the spray hole 13.

[0054] At the tail of the atomizing drug delivery hose 1, the air flow chamber 11 is connected to a gas supply device 2, and the liquid medicine chamber 12 is connected to a drug dispenser 3.

[0055] The pressurized air flow from the gas supply device 2 is ejected through the narrow air jet hole 13 in the air flow chamber 11, generating a negative pressure at the air jet hole 13. The liquid medicine discharged from the drug dispenser 13 through the liquid medicine chamber 12 is inhaled into the air flow and dispersed into a mist at the air jet hole 13.

[0056] The atomizing drug delivery hose 1 with a length greater than 200 mm serves as the flow channel for air flow and liquid medicine. The air flow passes through the relatively thicker inner diameter air flow chamber 11, and the liquid medicine passes through the relatively narrower liquid medicine chamber 12. After the air flow passes through the air flow chamber 11, it is ejected from the air jet hole 13 provided at the head end of the air flow chamber 11. The area of the air jet hole 13 is not greater than 0.3 times the cross-sectional area of the air flow chamber 11, and the flow velocity of the air flow ejected from the air jet hole 13 increases by more than 3 times, thereby forming a negative pressure on the side wall of the air jet hole 13. At the same time, after the atomized liquid medicine passes through the liquid medicine chamber 12, it flows out at a relatively small flow velocity from the liquid medicine outlet hole 14 provided at the edge of the air jet hole 13. Under the action of the negative pressure generated by the high-speed air flow passing through the air jet hole 13, the liquid medicine flowing out through the liquid medicine outlet hole 14 is inhaled into the jet air flow and dispersed into a mist under the collision of the high-speed air flow, thereby realizing the atomizing effect of the air flow on the liquid medicine. The liquid medicine outlet hole 14 forms an angle of 45 - 90° with the central axis of the air jet hole 13. Here, the angle refers to the minimum angle between the liquid medicine outlet hole 14 and the perpendicular line of the plane of the air jet hole 13, and the maximum does not exceed 90°. In specific implementation, the larger the angle between the liquid medicine outlet hole 14 and the plane of the air jet hole 13, the better, and 90° is the best, which is conducive to the liquid medicine being inhaled into the air flow by the negative pressure of the high-speed air flow in the air jet hole 13 after flowing out of the liquid medicine outlet hole 14 and then being atomized.

[0057] The gas supply device 2 provides gas with a certain flow velocity and pressure for the air flow chamber 11 during atomization implementation. It can be a manual gas supply device or an electric gas supply device. According to the thickness of the air flow chamber 11, the air flow velocity can be 2 - 15 L / min. In the present invention, the pipeline of the liquid medicine chamber 12 is long and the inner cavity is narrow. It is difficult to meet the liquid medicine discharge requirement only relying on the negative pressure generated by the high-speed air flow passing through the air jet hole 13. The drug dispenser 3 should provide a certain driving force for the liquid medicine flow. It can discharge the liquid manually, squeeze the liquid mechanically, or control the liquid discharge under the action of electricity. The liquid discharge speed is much smaller than the air flow velocity. The gas flow velocity given by the gas supply device, the liquid medicine flow velocity given by the drug dispenser 3, and the ratio of the flow areas of the air jet hole 13 and the air flow chamber 11 jointly determine the size of the aerosol particles after liquid medicine atomization. The greater the gas flow velocity given by the gas supply device, the smaller the liquid medicine flow velocity given by the drug dispenser 3, and the smaller the ratio of the flow areas of the air jet hole 13 and the air flow chamber 11, the smaller and more uniform the aerosol particles of the atomized liquid medicine.

[0058] Furthermore, as Figure 1As shown, the atomizing drug delivery hose 1 has a single-tube double-chamber structure. The main chamber is the air flow chamber 11, and the secondary chamber is the liquid medicine chamber 12. The head end of the atomizing drug delivery hose 1 is closed to form a blind end. Adjacent to the blind end, an air jet hole 13 is provided in the liquid medicine chamber 2 that penetrates the side wall of the atomizing drug delivery hose 1. The liquid medicine chamber 2 is penetrated by the air jet hole 13 to form a medicine outlet hole 14 at the opening. A 120-180° corner is provided 5-15 mm away from the tail side of the air jet hole 13 and is bent away.

[0059] The atomizing drug delivery hose 1 is set to have a single-tube double-chamber structure and is made by an extrusion molding process, so that the main chamber air flow chamber 11 and the secondary chamber liquid medicine chamber 12 are integrally formed. The thickness and length of the atomizing drug delivery hose 1 can be arbitrarily controlled according to clinical needs to meet various clinical scenarios. When necessary, the outer diameter of the atomizing drug delivery hose 1 can be made to be 1-3 mm to meet the need for local atomizing drug delivery in a narrow body cavity. The head end of the atomizing drug delivery hose 1 is closed to form a blind end. Adjacent to the blind end, an air jet hole 13 is provided in the liquid medicine chamber 2 that penetrates the side wall of the atomizing drug delivery hose 1. The air jet hole 13 penetrates the side wall of the drug delivery hose 1 and at the same time penetrates and communicates with the corresponding local main chamber air flow chamber 11, forming the only air flow outlet for the main chamber air flow chamber 11. The area of the air jet hole 13 should be less than 0.3 times that of the main chamber air flow chamber 11, and it is preferably set to 0.05-0.1 times the area of the main chamber air flow chamber 11. When the air flow in the main chamber air flow chamber 11 flows through the air jet hole 13, the gas velocity increases by more than 3 times, and it is preferably 10-20 times. A negative pressure is formed at the edge of the air jet hole 13 by the high-speed air flow. The head side opening of the liquid medicine chamber 2 after being penetrated by the air jet hole 13 forms a medicine outlet hole 14. The medicine outlet hole 14 is located at the tail side edge of the air jet hole 13. After the liquid medicine in the liquid medicine chamber 2 is discharged from the air jet hole 13, it is sucked into the air flow by the negative pressure of the high-speed air flow and is atomized. It should be noted that in this implementation scheme, the cross-section of the liquid medicine chamber 2 determines the size of the medicine outlet hole 14, and the two are of the same size. In order to control the air flow velocity and the liquid discharge ratio, the cross-section of the liquid medicine chamber 2 should be less than 0.3 times that of the main chamber air flow chamber 11, and it is preferably 0.05-0.1 times.

[0060] The greatest advantage of the atomizing drug delivery hose 1 with a single-tube double-chamber structure is that it is suitable for inserting and extending the extremely thin atomizing drug delivery hose 1 (with an outer diameter of 2.5-2.8 mm or 1.5-1.8 mm) into and out of the head end of the endoscope through the endoscopic operation channel (a channel with an inner diameter of 3 mm or 2 mm), and locally atomizing and delivering drugs to the inner wall of the body cavity under endoscopic visualization. For example, in digestive tract fluoroscopy, fluoroscopy of the inner wall of the airway under bronchoscopy or bronchoscope, which is beneficial to evenly contact the local inner wall of the body cavity after atomizing the fluorescent agent, improving the recognition degree of fluoroscopy; at the same time, reducing the dosage of the fluorescent agent and avoiding the adverse hazards of the fluorescent agent.

[0061] The current alternative method of temporarily atomizing and administering a fluorescent agent during fluoroscopy is as follows: Seal the head end of a suitable hose and puncture several micropores. After placing it into and extending it out of the endoscopic operation channel, connect a syringe to the tail end of the hose and directly inject and extrude the liquid medicine. It is similar to a shower nozzle, with extremely poor atomization effect. The fluorescent agent on the inner wall of the body cavity is extremely uneven, the dosage of the fluorescent agent is large, and it seriously affects the effect of fluorescence endoscopy examination.

[0062] At a position 5 - 15 mm on the tail side of the atomizing drug delivery hose 1 away from the gas spraying hole 13, a 120 - 180° corner is bent away. Specifically, it is the included angle between the long axes on both sides of the first and last positions of the bend of the atomizing drug delivery hose 1. Through the bending setting of a 120 - 180° corner at a position 5 - 15 mm on the tail side of the gas spraying hole 13, the gas spraying hole 13 originally located on the side of the head end of the atomizing drug delivery hose 1 returns to its natural state after exiting the endoscopic operation hole, making the gas spraying hole 13 face the center of the body cavity directly, which is convenient for quickly and evenly atomizing and administering drugs to the annular inner wall of the body cavity under endoscopic visualization.

[0063] Further, as Figures 2-5 shown, the atomizing drug delivery hose 1 has a double - tube structure. The main tube is the air flow cavity 11, and the secondary tube is the liquid medicine cavity 12; the cross - sectional area of the main tube cavity is larger than that of the secondary tube cavity, at least more than 3 times the cross - sectional area of the secondary tube cavity. The secondary tube cavity can be arranged inside the main tube cavity, as Figures 2-4 ; or it can be arranged inside and outside the main tube cavity, as Figure 5 ; depending on clinical needs, it is preferably arranged inside the main tube cavity.

[0064] The head end of the air flow cavity 11 is hermetically connected and provided with a medicine spraying tube head 15. The medicine spraying tube head 15 has a tubular structure, and its tail is adapted to the head - side opening of the air flow cavity 11 and can be hermetically connected and communicated with the head - side opening of the air flow cavity 11. The inner cavity of the medicine spraying tube head 15 is tubular, and the air outlet on the head side is less than 0.3 times the cross - section of the air flow cavity 11, forming a gas spraying hole 13 at the head - side port of the medicine spraying tube head 15. A medicine outlet hole 14 is arranged at the edge of the gas spraying hole 13 communicating with the liquid medicine cavity 12. Specifically: The medicine outlet hole 14 is arranged on the inner wall of the gas spraying hole 13 on the head side of the medicine spraying tube head 15, and the medicine outlet hole 14 penetrates through the side wall or the tail end of the medicine spraying tube head 15. A connection port is arranged on the side wall or the tail end of the medicine spraying tube head 15 and is hermetically communicated with the liquid medicine cavity 12. The liquid medicine in the liquid medicine cavity 12 is discharged through the medicine outlet hole 14 on the inner side edge of the gas spraying hole 13. The advantage of the medicine spraying tube head 15 is that the medicine outlet hole 14 is directly arranged at the head end of the air flow cavity 11, with a correct position; the disadvantage is that it is necessary to add pipelines for assembling the air flow cavity 11 and the liquid medicine cavity 12, and the implementation difficulty is relatively large for pipelines below 3 mm.

[0065] In order to further control the discharge of the medicine applicator 3 and avoid accidental loss of the liquid medicine during non-atomization operations, a control switch is locally provided corresponding to the liquid medicine chamber 12; the control switch is linked with the air flow chamber 11; during the atomization operation, the air supply device 2 supplies air, pressurizes and supplies air to the air flow chamber 11, and under the pressure feedback, the control switch automatically opens, the liquid medicine chamber 12 is communicated, and the liquid medicine of the medicine applicator 3 is discharged through the liquid medicine chamber 12 and atomized by the air flow; when the atomization operation stops, the air supply device 2 stops supplying air, the pressure feedback stops, the air flow chamber 11 stops supplying air, the control switch automatically closes, the liquid medicine chamber 12 is blocked, and the liquid medicine of the medicine applicator 3 stops flowing into the liquid medicine chamber 12, and the atomization stops. The control switch can be set as a pressure-sensing electric control or a mechanical structure.

[0066] Specifically, as Figure 6 shown, it is a control switch for the liquid medicine chamber 12 with a mechanical structure. The control switch includes a bladder chamber 16 communicated with the air flow chamber 11. The pressure bladder chamber 16 is a thin-walled bladder body that expands under gas pressure and elastically restores when the gas pressure disappears. A control rod 17 is arranged adjacent to the bladder chamber 16 and penetrates through the liquid medicine chamber 12. The control rod 17 is correspondingly provided with a medicine-passing hole 18 for the liquid medicine chamber 12, and an elastic body 19 is sleeved outside the control rod. In the initial state, the elastic body 19 is in an elastically compressed state. Under the elastic action of the elastic body 19, the medicine-passing hole 18 of the control rod 17 is misaligned with the liquid medicine chamber 12, and the control rod 17 penetrates through and blocks the liquid medicine chamber 12.

[0067] The air supply device 2 supplies air, pressurizes and supplies air to the air flow chamber 11. The pressure of the air flow chamber 11 increases, the bladder chamber 16 expands, pushes the control rod 17 to shift, further compresses the elastic body 19, and then makes the medicine-passing hole 18 fit and align with both sides of the liquid medicine chamber 12, so that the medicine-passing hole 18 matches and aligns with both sides of the liquid medicine chamber 12 and communicates with the liquid medicine chamber 12. The liquid medicine of the medicine applicator 3 flows into the liquid medicine chamber 12 and is discharged through the medicine outlet hole 14. The discharged liquid medicine is sucked into the air flow by the negative pressure generated by the high-speed air flow at the tail side edge of the air jet hole 13 at the head end of the air flow chamber 11 and is atomized and ejected. When the air supply of the air supply device 2 stops, the air flow in the air flow chamber 11 stops, the pressure of the air flow chamber 11 drops, the bladder chamber 16 elastically resets, and under the re-expansion action of the elastic body 19, the control rod 17 is pushed to shift. Finally, the elastic body 19 returns to the initial slightly compressed state, and at the same time, the control rod 17 returns to its original position, the medicine-passing hole 18 is misaligned with both sides of the liquid medicine chamber 12, the liquid medicine chamber 12 is blocked, the liquid medicine of the medicine applicator 3 no longer flows into the liquid medicine chamber 12, the medicine outlet hole 14 no longer discharges the liquid medicine, and the atomization stops. Thus, when the air supply device 2 supplies air, the medicine applicator 3 discharges liquid and atomizes and administers medicine; when the air supply device 2 stops supplying air, the medicine applicator 3 stops discharging liquid, and the atomization and administration of medicine are paused; the air supply of the air supply device 2 is linked with the discharge and atomization of the liquid medicine, avoiding waste of the liquid medicine.

[0068] Furthermore, as Figure 1As shown, the length of the atomizing drug delivery hose 1 is 400 - 1000 mm, and the outer diameter is set to 1.5 - 1.8 mm or 2.5 - 2.8 mm.

[0069] The air supply device 2 and the drug applicator 3 are integrally set as a double - chamber syringe 31. The double - chamber syringe 31 includes an air injection chamber 32 and a drug injection chamber 33. The cross - section ratio of the air injection chamber 32 to the drug injection chamber 33 is greater than 5; the push - rod pistons 34 of the air injection chamber 32 and the drug injection chamber 33 are integrally linked.

[0070] This embodiment is mainly used for fluorescence atomization or rapid local drug delivery in the body cavity during endoscopic examination. The operation cavity of the endoscope is 2 mm or 3 mm. The atomizing drug delivery hose 1 with an outer diameter of 1.5 - 1.8 mm can be smoothly inserted through the 2 - mm operation cavity of the endoscope, and the atomizing drug delivery hose 1 with an outer diameter of 2.5 - 2.8 mm can be smoothly inserted through the 3 - mm operation cavity of the endoscope. After being inserted into and extending out of the operation cavity of the endoscope, it can perform local atomizing drug delivery on the inner wall of the body cavity to perform fluorescence endoscopy or local treatment. The length of the atomizing drug delivery hose 1 is 400 - 1000 mm, which can meet the usage requirements of endoscopes with different lengths. The optimal length of the atomizing drug delivery hose 1 should be 3 - 5 cm longer than the operation cavity of the endoscope, which is convenient for operation during use.

[0071] For fluorescence endoscopy or local drug delivery, the volume of the drug solution is small, and there are no high requirements for the size of the atomized particles. The main requirements are uniform drug delivery and it needs to be completed within 1 - 5 minutes. To meet the above requirements, the air supply device 2 and the drug applicator 3 are preferably integrally set as a double - chamber syringe 31. The double - chamber syringe 31 includes an air injection chamber 32 and a drug injection chamber 33. The air injection chamber 32 undertakes the function of the air supply device 2, and the drug injection chamber 33 undertakes the function of the drug applicator 3. The cross - section ratio of the air injection chamber 32 to the drug injection chamber 33 is greater than 5, so that the gas volume of the air injection chamber 32 is more than 5 times the volume of the drug injection chamber 33, and preferably 20 - 25 times. The lengths of the air injection chamber 32 and the drug injection chamber 33 are similar. The push - rod pistons 34 of the air injection chamber 32 and the drug injection chamber 33 are integrally linked. When the push - rod piston 34 is pushed so that the gas in the air injection chamber 32 is ejected through the air injection hole 13, the drug solution in the drug injection chamber 33 is synchronously discharged through the drug outlet hole 14. The air flow rate is 20 - 25 times the drug solution flow rate. When the push - rod piston 34 is pushed to the bottom of the double - chamber syringe 31, the air injection ends, and the drug solution in the drug injection chamber 33 is also exhausted, so as to achieve the purpose of rapid and accurate local atomizing drug delivery. During clinical implementation, the volume of the air injection chamber 32 is 50 ml, and the volume of the drug injection chamber 33 is preferably 2 ml. Interfaces are respectively provided at the tails of the air flow chamber 11 and the drug solution chamber 12 for temporary fixation with the head - side injection interfaces of the air injection chamber 32 and the drug injection chamber 33. When multiple atomizing drug deliveries are required, the double - chamber syringe 31 is removed from the tail of the atomizing drug delivery hose 1, a needle is connected to the head - side injection interface of the drug injection chamber 33, and the atomizing drug solution is re - aspirated. At the same time, the air injection chamber 32 is filled with gas; after the drug - drawing and gas - filling are completed, after removing the needle, it is re - connected and fixed to the tail interfaces of the air flow chamber 11 and the drug solution chamber 12, and then the rapid quantitative atomizing drug delivery can be repeated again.

[0072] Further, as Figures 2-4 shown, the length of the atomizing drug delivery hose 1 is 300 - 500 mm, and the outer diameter is set to 1.5 - 4 mm.

[0073] The tail movable ring sleeve of the atomizing drug delivery hose 1 is connected to the connecting tee 4, and the connecting tee 4 is connected to a catheter interface 41, a loop interface 42 and an atomizing inlet 43; the catheter interface 41 is adapted to the respiratory interface of the tracheal catheter; the loop interface 42 is adapted to the threaded tube interface; the atomizing inlet 43 is hermetically adapted to the outer diameter of the atomizing drug delivery hose 1.

[0074] The gas supply device 2 includes an air pump 21 and a medical oxygen source 22; the drug dispenser 3 is set as an automatic drug dispenser, including an elastic medicine bag, an injection micro-pump and a hanging medicine bag.

[0075] This embodiment is mainly used for deep airway atomizing drug delivery to intubated patients. The atomizing drugs are mainly hormones, antispasmodic drugs, expectorant drugs and antibiotics. Such as: dexamethasone, budesonide, salbutamol, montelukast, adrenaline, ammonium chloride, ambroxol, bromhexine, and bacteria-sensitive antibiotics, etc. For different conditions, 1 - 3 kinds of liquid medicines are selected to atomize and deliver drugs to the deep airway separately or simultaneously.

[0076] Specifically described as follows: To reduce the product models of the present invention and lower the production cost. The tracheal catheters of pediatric patients are thinner and shorter. A thinner and shorter atomizing drug delivery hose 1 can be selected, with a length of 400 mm and an outer diameter of 1.5 mm, which can meet all requirements and will not block the inner cavity of the tracheal catheter and can meet the requirements of mechanical ventilation; for adult tracheal patients, the tracheal catheters are thicker and longer. A slightly longer and thicker atomizing drug delivery hose 1 can be selected, with a length of 500 mm and an outer diameter of 3.5 mm to meet the requirements. Of course, when the airway of an adult with respiratory spasm has a narrow tracheal lumen, the pediatric model atomizing drug delivery hose 1 can be used for atomizing inhalation.

[0077] When an intubated patient undergoes atomizing inhalation, the catheter interface 41 of the connecting tee 4 is hermetically connected to the respiratory interface of the tracheal catheter, the loop interface 42 is hermetically connected to the threaded tube end of the ventilator or anesthetic machine, and then the atomizing drug delivery hose 1 is inserted into the patient's airway to an appropriate depth through the atomizing inlet 43. According to the specific condition, different depths are inserted: for main tracheal diseases, it is best that the head end of the atomizing drug delivery hose 1 is at a position 10 - 20 mm above the carina; for bronchial diseases, the head end of the atomizing drug delivery hose 1 is best at the corresponding bronchial lesion site. At this time, the three tube ends of the connecting tee 4 are hermetically connected to the corresponding pipelines respectively, and deep airway atomizing inhalation treatment can be carried out while mechanical ventilation is supported by the ventilator.

[0078] Since the amount of atomized medicine required for respiratory diseases is relatively large (5 - 15 ml) and the time is relatively long (30 - 60 minutes each time), at this time, the air supply device 2 needs to continuously supply air to the air injection chamber 32, such as Figures 2-3 , an air pump 21 with a separate battery or external power supply can be selected (a gas filter 23 should be installed at the air inlet of the air pump 21 to ensure the cleanliness of the gas), or such as Figure 4 , use a medical oxygen source in a medical scenario as the air supply device 2. Set the power of the air pump 21 according to the specific condition of the disease or adjust the air supply flow rate through the oxygen cylinder of the oxygen source. At the same time, the medicine dispenser 3 needs to continuously discharge the liquid medicine into the medicine injection chamber 33, and an elastic medicine bag ( Figure 2 ), a medicine injection micro-pump, and a hanging medicine bag ( Figures 3-4 ) can be selected. Elastic medicine bags are commonly used in analgesia pumps, and the medicine discharge speed and time are controlled by the elasticity of the elastic medicine bag, the wall thickness, and the inner diameter of the medicine outlet tube. The medicine injection micro-pump is also a commonly used device in the medical scenario. The liquid medicine is aspirated into the syringe and clamped in the medicine injection micro-pump. By adjusting the medicine injection speed of the medicine injection micro-pump, the liquid medicine discharge speed can be accurately controlled, and the illustration is omitted. In a simple condition, a hanging medicine bag can also be selected. Observe the drip speed through the drip chamber, and adjust the inner diameter of the pipeline flow through the infusion regulator to control the liquid discharge speed of the hanging medicine bag. To reduce costs and achieve single-use, in a medical scenario, the air supply device 2 preferably selects an oxygen source equipped with an oxygen cylinder, and the medicine dispenser 3 preferably selects a medicine injection micro-pump, which has the lowest cost, can accurately control, and can also provide oxygen inhalation for the patient during atomization treatment.

[0079] Furthermore, as Figure 5 shown, the length of the atomized medicine delivery hose 1 is 800 - 3000 mm, and the outer diameter is set to 15 - 40 mm.

[0080] The air supply device 2 includes an air pump 21 and a medical oxygen source 22; the medicine dispenser 3 is set as an automatic medicine delivery device, including an elastic medicine bag, a medicine injection micro-pump, and a hanging medicine bag;

[0081] A perforated face mask or a mouthpiece is connected and set at the head end of the atomized medicine delivery hose 1.

[0082] This embodiment is mainly applicable to the atomization inhalation of non-intubated patients, such as infections of the respiratory system and patients with mild asthma. The atomized medicine is inhaled through the perforated face mask or mouthpiece worn on the patient's mouth and nose. Its advantage is that through the bending and deformation of the atomized medicine delivery hose 1, the medicine dispenser 3 is far away from the atomized medicine outlet, enabling weak patients to perform atomization inhalation in the lateral position or supine position, and enabling young children to perform atomization inhalation in the supine sleeping state, improving the comfort and feasibility of atomization inhalation.

[0083] In this embodiment, the length of the atomizing drug delivery hose 1 is 800 - 3000 mm, which facilitates placing the air supply device 2 and the drug dispenser 3 on the bedside table far from the patient's head. In this scenario, there is no restriction on the outer diameter of the pipeline. The amount of atomized treatment drug is large and the time is long. It is most suitable to set its outer diameter to 15 - 40 mm, which can provide a larger air flow rate, achieve smaller atomized particles of aerosol particles, and can provide more delicate aerosol inhalation treatment in the airway and even the alveoli when needed.

[0084] The air supply device 2 can select an air pump 21 in a household environment, and preferably selects a medical oxygen source 22 in a medical scenario; the drug dispenser 3 is set as an automatic drug delivery device. In a medical condition, a drug injection micro-pump and a hanging medicine bag are preferred, and a professional adjusts the drug delivery speed precisely; in a household environment, an elastic medicine bag is preferred, and a non-professional family member correctly implements atomized treatment.

[0085] Furthermore, the air pump is electrically connected to a set chip to precisely control the power of the air pump; a gas filter 23 is arranged at the air inlet of the air pump 21. In a household environment, the drug delivery speed of the drug dispenser 3 is constant. The particle size of the aerosol during atomized treatment can be adjusted by precisely controlling the power of the air pump 21. The greater the power of the air pump 21, the greater the air flow rate, and the smaller the aerosol particles. Larger aerosol particles are mainly used for the treatment of main airway diseases, smaller aerosol particles are used for the treatment of finer small airway diseases, and even smaller aerosol particles are used for the treatment of diseases in delicate airways and alveoli.

[0086] Furthermore, as Figure 7 shown, a number of three-way tubular adjusting accessories 5 are provided with the medicine spraying pipe head 15; a secondary spray hole 51 is arranged through the long axis of the adjusting accessory 5, and a secondary medicine outlet hole 52 is arranged through one side side wall communicating with the secondary spray hole 51.

[0087] The outer shape of the adjusting accessory 5 matches the spray hole 13 of the medicine spraying pipe head 15. The secondary spray hole 31 is smaller than the spray hole 13, and the secondary medicine outlet hole 52 is smaller than the medicine outlet hole 14.

[0088] The adjusting accessory 5 is adaptively and hermetically assembled in the spray hole 13. The secondary spray hole 51 is hermetically communicated with the spray hole 13. At the same time, the secondary medicine outlet hole 52 is hermetically communicated with the medicine outlet hole 14.

[0089] This is a specific embodiment for Figure 5 a household environment. At this time, the air supply device 2 selects an air pump 21, and the power is fixed (the best air flow rate is 10 L / min). By selecting different specifications of adjusting accessories 5, after correct assembly, the spray hole 13 is changed to the secondary spray hole 31, and the medicine outlet hole 14 is changed to the secondary medicine outlet hole 52. Thus, on the premise that the power of the air pump 21 remains unchanged, different adjusting accessories 5 are selected for different conditions, and the particle size of the aerosol during atomized treatment is changed for the treatment of different respiratory conditions.

[0090] In specific implementation, only two specifications of adjustment accessories 5 need to be configured: the spray holes 13 and the medicine outlet holes 14 of the medicine spraying pipe head 15 are the largest. When the adjustment accessory 5 is not assembled, the aerosol particles during its atomization treatment are controlled to be 5 - 10 μm, which is used for the treatment of tracheal diseases; the inner diameters of the secondary spray holes 31 and the secondary medicine outlet holes 52 of one adjustment accessory 5 are slightly smaller, and the aerosol particles during its atomization treatment are controlled to be 2 - 5 μm, which is used for the treatment of bronchial diseases; the inner diameters of the secondary spray holes 31 and the secondary medicine outlet holes 52 of the other adjustment accessory 5 are the smallest, and the aerosol particles during its atomization treatment are controlled to be 0.5 - 1 μm, which is used for the treatment of alveolar diseases. The specific sizes of the spray holes 13 and the medicine outlet holes 14 of the medicine spraying pipe head 15, and the specific sizes of the secondary spray holes 31 and the secondary medicine outlet holes 52 of the two specifications of adjustment accessories 5 are related to the power of the air pump 21 and there are no fixed sizes.

[0091] In summary, through the unique structural design of the present invention, the outer diameter of the atomization pipeline is no longer restricted, and it can be minimized to 1.5 mm, changing the current situation that existing atomization treatment can only be implemented outside the mouth and nose, and it can be used for precise atomization in deep body cavities for examination or treatment; at the same time, the atomization treatment is not restricted by the requirement that the medicine bottle must be upright, enabling patients to receive atomization treatment in the lying position, increasing the comfort and cooperation of atomization treatment, with low cost and being convenient for transformation and popularization.

[0092] The above embodiments only illustratively explain the principle and its efficacy of this patent application, rather than being used to limit this patent application. Any person familiar with this technology can modify or change the above embodiments without departing from the spirit and scope of this patent application. Therefore, all equivalent modifications or changes completed by those with ordinary knowledge in the technical field without departing from the spirit and technical idea disclosed by this patent application should still be covered by the claims of this patent application.

Claims

1. Long tube atomizer, characterized by: The invention comprises an atomizing drug delivery hose (1) with a length greater than 200 mm, wherein the atomizing drug delivery hose (1) comprises an air flow chamber (11) and a drug solution chamber (12), wherein an air jet hole (13) is arranged at the head end of the air flow chamber (11), and the area of ​​the air jet hole (13) is not greater than 0.3 times the cross section of the air flow chamber (11); The medicine liquid cavity (12) is provided with a medicine outlet hole (14) at the head end, and the medicine outlet hole (14) is arranged at the edge of the air jet hole (13); the medicine outlet hole (14) and the central axis of the air jet hole (13) form an angle of 45-90 degrees; At the tail end of the atomizing drug delivery hose (1), the air flow chamber (11) is connected to an air supply device (2), and the drug liquid chamber (12) is connected to a drug delivery device (3); The pressurized air flow of the air supply device (2) is ejected through the air flow chamber (11) at the narrow air jet hole (13), generating negative pressure at the air jet hole (13), sucking the liquid medicine discharged from the drug delivery device (13) through the liquid medicine chamber (12) at the medicine outlet hole (14) into the air flow and blowing it into a mist.

2. The long tube atomizing drug delivery device according to claim 1, characterized in that: The atomizing drug delivery hose (1) is a single-tube dual-cavity structure, wherein the main cavity is an airflow cavity (11), and the secondary cavity is a liquid medicine cavity (12); the head end of the atomizing drug delivery hose (1) is closed to form a blind end, and an air jet hole (13) is provided adjacent to the liquid medicine cavity (12) penetrating the side wall of the atomizing drug delivery hose (1) through the blind end, and the opening of the liquid medicine cavity (12) penetrated by the air jet hole (13) forms a drug outlet hole (14); and a 120-180° bend is provided at a position 5-15 mm away from the tail side of the air jet hole (13).

3. The long tube atomizing drug delivery device according to claim 1, characterized in that: The atomizing drug delivery hose (1) is a double-tube structure, the main tube is an air flow chamber (11), and the secondary tube is a drug liquid chamber (12); The head end of the airflow cavity (11) is sealed and connected to a medicine spraying pipe head (15), and a nozzle hole (13) is formed at the head side port of the medicine spraying pipe head (15); a medicine outlet hole (14) is provided at the edge of the nozzle hole (13) and is connected to the medicine liquid cavity (12).

4. The long tube atomizing drug delivery device according to claim 1, characterized in that: The medicine liquid chamber (12) is provided with a control switch; the control switch is linked to the airflow chamber (11); when the airflow chamber (11) is pressurized to supply air, the control switch is opened and the medicine liquid chamber (12) is connected; when the airflow chamber (11) stops supplying air, the control switch is closed and the medicine liquid chamber (12) is blocked.

5. The long tube atomizing drug delivery device according to claim 4, characterized in that: The control switch comprises a capsule cavity (16) connected to the airflow cavity (11), a control rod (17) is arranged adjacent to the capsule cavity (16) and penetrates the liquid medicine cavity (12), a medicine passage hole (18) is arranged corresponding to the control rod (17) and the liquid medicine cavity (12), and an elastic body (19) is arranged on the outer surface of the control rod; When the pressure of the airflow chamber (11) increases, the bladder chamber (16) expands, pushing the control rod (17) to shift, and the medicine hole (18) and the medicine liquid chamber (12) are adapted to align; when the pressure of the airflow chamber (11) decreases, the bladder chamber (16) recovers, the elastic body (19) elastically resets, pushing the control rod (17) to reset, and the medicine hole (18) and the medicine liquid chamber (12) are misaligned and blocked.

6. The long tube atomizing drug delivery device according to claim 2, characterized in that: The atomizing drug delivery hose (1) has a length of 400-1000 mm and an outer diameter of 1.5-1.8 mm or 2.5-2.8 mm; The air supply device (2) and the drug dispenser (3) are integrally arranged as a double-chamber syringe (31), the double-chamber syringe (31) comprising an air injection chamber (32) and a drug injection chamber (33), the cross-sectional ratio of the air injection chamber (32) to the drug injection chamber (33) being greater than 5; the push rod piston (34) of the air injection chamber (32) and the drug injection chamber (33) are integrally linked.

7. The long tube atomizing drug delivery device according to claim 1, characterized in that: The atomizing drug delivery hose (1) has a length of 800-3000 mm and an outer diameter of 15-40 mm; The air supply device (2) comprises an air pump (21) and a medical oxygen source (22); the drug delivery device (3) is configured as an automatic drug delivery device, comprising an elastic drug bag, a drug injection micro pump and a hanging drug bag; A mask with holes or a mouth tube is connected to the head end of the atomizing drug delivery hose (1).

8. The long tube atomizing drug delivery device according to claim 1, characterized in that: The atomizing drug delivery hose (1) has a length of 300-500 mm and an outer diameter of 1.5-4 mm; The tail of the atomizing drug delivery hose (1) is movably provided with a connecting tee (4), and the connecting tee (4) is connected to a catheter interface (41), a loop interface (42) and an atomizing inlet (43); the catheter interface (41) is adapted to the breathing interface of the tracheal tube; the loop interface (42) is adapted to the threaded pipe interface; the atomizing inlet (43) is sealed and adapted to the outer diameter of the atomizing drug delivery hose (1); The air supply device (2) comprises an air pump (21) and a medical oxygen source (22); the drug delivery device (3) is configured as an automatic drug delivery device, comprising an elastic drug bag, a drug injection micro pump and a hanging drug bag.

9. The long tube atomizing drug delivery device according to claim 7 or 8, characterized in that: The air pump is electrically connected to a chip to accurately control the power of the air pump; and a gas filter (23) is arranged at the air inlet of the air pump.

10. The long tube atomizing drug delivery device according to claim 3, characterized in that: The spraying pipe head (15) is provided with a plurality of three-way tubular adjusting accessories (5); a secondary jet hole (51) is provided through the long axis of the adjusting accessory (5); and a secondary medicine outlet hole (52) is provided through the side wall of one side of the adjusting accessory (5) and connected to the secondary jet hole (51); The shape of the accessory (5) is adjusted to match the jet hole (13) of the spray pipe head (15), the auxiliary jet hole (31) is smaller than the jet hole (13), and the auxiliary medicine outlet hole (52) is smaller than the medicine outlet hole (14); The regulating accessory (5) is adapted and sealed to be assembled in the air jet hole (13); the auxiliary air jet hole (51) is in sealed communication with the air jet hole (13); and at the same time, the auxiliary medicine outlet hole (52) is in sealed communication with the medicine outlet hole (14).

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