Method for preparing oxadiazole compound through visible light induced iron catalysis
Through visible light-catalyzed iron catalyst and inorganic salt system, the problem of cumbersome reaction steps and the use of dangerous chemical raw materials in the preparation of oxadiazole compounds is solved, and efficient and safe large-scale preparation is achieved.
CN120247833APending Publication Date: 2025-07-04DALIAN UNIV OF TECH
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Patent Information
- Application Number
- CN202510429646.X
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-04-08
- Publication Date
- 2025-07-04
AI Technical Summary
Technical Problem
The prior art has problems in the preparation of oxadiazole compounds with cumbersome reaction steps, the use of hazardous chemical raw materials and the production of toxic gases, making it difficult to achieve efficient and safe large-scale preparation.
Method used
The oxadiazole compound was prepared by decarboxylation coupling cyclization reaction using visible light catalysis method, using cheap and easy-to-get iron catalyst and inorganic salt as the source of "NO", and combining Lewis acid as an additive to achieve efficient conversion of N-Boc-amino acids.
Benefits of technology
It achieves clean and gentle reaction conditions, is easy to operate, has good selectivity, high conversion rate, wide application range, and is suitable for large-scale industrial production.
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Figure CN120247833A_ABST
Abstract
The invention belongs to the field of organic synthesis, and discloses a method for preparing an oxadiazole compound through visible light induced iron catalysis. According to the method, under the illumination condition, ferric salt is used as a catalyst, an N-Boc-amino acid compound is used as a raw material, Lewis acid is used as an additive, and decarboxylation coupling cyclization is performed to generate the aromatic aldehyde compound. The method has the beneficial effects that the reaction adopts photocatalytic reaction and is clean and pollution-free, the reaction condition is mild, the operation is simple and convenient, the selectivity is good, and the conversion rate is high; the inorganic salt is used for providing a NO source; iron salt which is cheap and easy to obtain and can be industrially prepared on a large scale is used as the photocatalyst.
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