Echinococcus granulosus antigen Eg73 and its encoding gene and application

By constructing a cDNA expression library of Echinococcus granulosus and screening out the Eg73 antigen, the problem of lack of protective antigens in the existing technology was solved, and the effective preparation of canine Echinococcus granulosus vaccine and the application of diagnostic reagents were realized.

CN120267809BActive Publication Date: 2025-09-09JILIN UNIVERSITY
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Patent Information

Application Number
CN202510771556.9
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2025-06-11
Publication Date
2025-09-09
Estimated Expiration
2045-06-11

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Abstract

An Echinococcus granulosus antigen Eg73 and its encoding gene and application belong to the field of immunology technology. The present invention utilizes a three-day-old Echinococcus granulosus larvae cDNA expression library to screen the Eg73 antigen protein in a high-throughput, unbiased manner, and further provides a method for preparing the antigen protein and its application, aiming to provide a new antigen target for the development of candidate antigens for canine anti-Echinococcus granulosus vaccines. This solves the current problem of stagnant vaccine development for canine anti-Echinococcus granulosus infection and lagging protective antigen screening. The amino acid sequence of the antigen protein is shown in SEQ ID NO.6, and the nucleotide sequence encoding the antigen protein is shown in SEQ ID NO.7. It has been verified that the antigen protein can specifically react with positive serum from dogs infected with Echinococcus granulosus, and has high application value in the research and development of canine anti-Echinococcus granulosus vaccines and diagnostic reagents.
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Citation Information

Patent Citations

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