Echinococcus granulosus antigen Eg73 and its encoding gene and application
By constructing a cDNA expression library of Echinococcus granulosus and screening out the Eg73 antigen, the problem of lack of protective antigens in the existing technology was solved, and the effective preparation of canine Echinococcus granulosus vaccine and the application of diagnostic reagents were realized.
Patent Information
- Application Number
- CN202510771556.9
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2025-06-11
- Publication Date
- 2025-09-09
- Estimated Expiration
- 2045-06-11
AI Technical Summary
The lack of effective protective antigens in the existing technology has led to a stagnation in the development of canine Echinococcus granulosus vaccines, and the inability to identify antigens that trigger protective immune responses.
By constructing a cDNA expression library of three-day-old larvae of Echinococcus granulosus, the serum probe was screened using the pseudoscreen method, and the Eg73 antigen protein was screened out. The recombinant expression vector was then used to prepare a canine anti-Echinococcus granulosus vaccine.
The Eg73 protein that can react with positive serum from dogs infected with Echinococcus granulosus was identified and prepared, and can be used for canine anti-Echinococcus granulosus vaccines and diagnostic reagents, which has high application value.