Binary insecticidal and acaricidal composition preparation and application thereof

Abstract

The invention belongs to the field of insecticides and acaricides, and relates to a binary insecticidal and acaricidal composition preparation and application thereof. The binary insecticidal and acaricidal composition preparation comprises an active component, at least one auxiliary agent and a carrier, the active components comprise an active component A and an active component B, the active component A has the following structure, and the active component B is selected from nereistoxin insecticides (B1), macrolide insecticides (B2), organophosphorus insecticides (B3), carbamate insecticides (B4), tetronic acid insecticides (B5), biological source insecticides (B6), pyrethroid insecticides (B7) and insect growth regulator insecticides (B8); the pesticide composition comprises one or more of an amide pesticide (B9), a nicotine pesticide (B10), an insect ingestion retardation pesticide (B11), a bactericide (B12), an acaricide (B13) and an inorganic substance (B14); the active component A has the following structure; the preparation provided by the invention can be used for preventing and treating various pests and pest mites. # imgabs0 #

Description

Technical Field

[0001] The present invention belongs to the field of insecticides and acaricides, and relates to a binary insecticidal and acaricidal composition preparation and its application. Background Art

[0002] Chemical pesticides are still the most important means to deal with crop pests and diseases at present, and play a crucial role in boosting the continuous stable yield and even improving the quality and increasing the yield of crops. However, the long-term and large-scale use of single-component pesticides has a single mechanism of action, which is easy to produce drug resistance, and there are certain limitations in application. By reasonably mixing insecticides / acaricides with different mechanisms of action, the control effect on target pests can be improved while the control range can be expanded. It can not only slow down the speed of pest resistance generation, but also extend the effective use time of insecticides. For this reason, exploring the combined compounding of different chemical pesticides to further innovate the application of existing chemical pesticides has always been the focus of the research on the efficient control of crop pests and diseases, and it is also the most effective shortcut at present and for some time to come.

[0003] According to the Chinese invention patent CN112457288 B, the piperic acid derivative compound A shown in formula I is publicly reported: The contact and stomach toxicity activities of compound A and its good conduction characteristics make it show good effects in controlling various pests. It can be used to control various pests such as Lepidoptera, Hemiptera, Thysanoptera, Coleoptera, Acarina, etc. The structure of this compound is unique, with a wide insecticidal spectrum and high activity. Different from other insecticides, compound A is not easy to cause cross-resistance in pests, which means it may become an environmentally friendly agent for controlling pests that have developed resistance to other agents. Especially for Thysanoptera pests, such as the world-recognized difficult-to-control pest Frankliniella occidentalis, etc., it has outstanding control effects.

[0004]

[0005] Pesticides need to be processed into preparation products through formulation technology to meet the application requirements in the fields of agriculture, forestry and hygiene. Through pesticide formulation technology, not only can the biological activity of compound pesticides be improved, the dosage be reduced, and the cost be saved, but also the pesticide utilization rate can be maximized, and the harm of pesticides to the environment can be reduced. Through literature retrieval, the technical scheme of a binary insecticidal and acaricidal composition preparation containing compound A has not been specifically disclosed. Summary of the Invention

[0006] The object of the present invention is to provide a binary insecticidal and acaricidal composition preparation and its application.

[0007] In order to achieve the object of the present invention, the technical scheme of the present invention is as follows:

[0008] A binary insecticidal and acaricidal composition preparation, the preparation comprising an active ingredient, at least one auxiliary agent and a carrier; the active ingredient is active component A and active component B, active component A has the following structure, and active component B is selected from nereistoxin insecticides (B1), macrolide insecticides (B2), organophosphorus insecticides (B3), carbamate insecticides (B4), tetronic acid insecticides (B5), biogenic insecticides (B6), pyrethroid insecticides (B7), insect growth regulator insecticides (B8), amide insecticides (B9), nicotinic insecticides (B 10 ), insect feeding deterrent insecticides (B 11 ), fungicides (B 12 ), acaricides (B 13 ), or one or several of other insecticides and inorganic substances (B 14 ); the weight ratio of active component A to active component B is 100:1 to 1:100 (preferably 50:1 to 1:50);

[0009] Active component A has the following structure:

[0010]

[0011] The nereistoxin insecticides (B1) are selected from: cartap, bisultap, monosultap, thiocyclam, bensultap, trithialan or polythialan;

[0012] The macrolide insecticides (B2) are selected from: avermectin, Tenvermectins, emamectin benzoate (abbreviation: emamectin), liuyangmycin, ivermectin, emamectin, milbemycin, mibelmycin, doramectin, acetylaminoavermectin, moxidectin, selamectin, enantemamectin, streptomycin, nikkomycins or Milbemycin Oxime;

[0013] The organophosphorus insecticides (B3) are selected from: acephate, chlorpyrifos, chlorpyrifos-methyl, omethoate, diazinon, methamidophos, monocrotophos, parathion-methyl, parathion, terbufos, phoxim, methidathion, triazophos, azinphos-methyl, azinphos-ethyl, chlorethoxyfos, chlorfenvinphos, chlormephos, coumaphos, cyanophos, phosmet, dichlorvos, dicrotophos, dimethylvinphos, disulfoton, EPN, ethion, fenthion, heptenophos, mecarbam, mevinphos, naled, oxydemeton-methyl, phenthoate, isofenphos, pirimiphos-methyl, tebupirimfos, propaphos, propetamphos, prothiofos, pyraclofos, pyridaphenthion, quinalphos, sulfotep, temephos, tetrachlorvinphos, thiometon, trichlorfon, acethion, malathion, phosalone, vamidothion, naftalofos, isoxathion, pyrazophos, fenitrothion, sulprofos, nitrothion,Azamethiphos, diazinon, fonofos, bromophos-ethyl, bromfenvinfos, trithion, cyanophenphos, demeton methyl, dioxabenzofos, flupyrazofos, formothion, fosmethilan, lodofenphos, iprobenfos, methacrifos, phosemet, pyridathion, prothoate, tebupirimfos;

[0014] The carbamate insecticides (B4) are selected from: Carbosulfan, CPMC, dimetan, pyrolan, prramat, isolan, methomyl, butocarboxim, carbaryl, fenothiocarb, methiocarb, mexathacarb, metolcarb, propoxur, thiofanox, triazamate, fenobucarb, benfuracarb, bendiocarb, furathiocarb, pirimicarb, butoxycarboxim, ethiofencarb, isoprocarb, trimethacarb, XMC, xylylcarb, fenoxycarb or nitrilacarb.

[0015] The tetronic acid insecticides (B5) are selected from: Spirodiclofen, Spirotetramat, Spiromesifen, spirotetramate, Spiropidion, spirodiclofen or spidoxamat;

[0016] Biogenic pesticides (B6) are selected from: microbial agents, matrine, cineole, mineral oil, star anise oil, allicin, ginkgol, d-limonene, diatomaceous earth, rotenone, azadirachtin, Celastrus angulatus extract, Cordyceps javanica, Veratrum grandiflorum extract, Paecilomyces sp., Aschersonia sp., Verticillium sp., osthole, chamaejasmin, tea saponin, oxymatrine, preparations containing nuclear polyhedrosis virus, preparations containing cytoplasmic polyhedrosis virus, preparations containing granulosis virus, Wugufengsu or coronatine.

[0017] Pyrethroid insecticides (B7) are selected from: bifenthrin; furethrin; gamma-cyhalothrin; barthrin; metofluthrin; fenpropathrin; methothrin; terallethrin; cyclethrin; beta-cypermethrin; lambda-cyhalothrin; cypermethrin; beta-cyfluthrin; cyfluthrin; tetramethrin; permethrin; etofenprox; deltamethrin; pyresmethrin; phenothrin; cyphenothrin; fenpirithrin; resmethrin; dimethrin; butethrin; transpermethrin; theta-cypermethrin; rich-d-t-tetramethrin; flucythrinate; tau-fluvalinate; proparthin; acrinathrin; silafluofen; flumethrin; pyrethrins; empenthrin; heptafluthrin; meperfluthrin; zeta-cypermethrin; chlorempenthrin; japothrins; tefluthrin; fenvalerate; esfenvalerate; prallethrin; furamethrin; imiprothrin; kadethrin; cyhalothrin;Flufenprox; Bioresmethrin; Biopermethrin; Bioallethrin; S-Bioallethrin; Cismethrin; Alpha-Cypermethrin; Transfluthrin; Dimefluthrin; Tetramethylfluthrin; Tralomethrin; Fenfluthrin; Valerate; Pentmethrin; Allethrin; Bromethrin; Brofluthrinate; Tralocythrin; Brofenvalerate; Cycloprothrin; D-Tetramethrin; D-Trans-Tetramethrin; Chloroprallethrin; heptaflumetylvalinate; Bioallethrin; Permethrin; D-Allethrin; Esbiothrin; Profluthrin; Momfluorothrin; Kappa-Tefluthrin; Kappa-Bifenthrin; Epsilon-Momfluorothrin; Epsilon-Metofluthrin; Alpha-Cypermethrin; Cis-Fenvalerate; Cyhalothrin; Esbiothrin; Es-Bioallethrin or D-Phenothrin.;

[0018] Insect growth regulator insecticides (B8) are chitin synthesis inhibitor insecticides, ecdysteroid insecticides or juvenile hormone insecticides;

[0019] The chitin synthesis inhibitor insecticides are: buprofezin, diflubenzuron, hexaflumuron, lufenuron, flufenoxuron, triflumuron, chlorfluazuron, teflubenzuron, dichlorbenzuron, fluazuron, noviflumuron, dichlorzine urea; flucofuron; flucycloxuron, bistrifluron, chlorbenzuron, penfluron, novaluron, juvenazole, chitiazole, thiazine urea, diafenthiuron, chloromethiuron, diflovidazin, cyromazine;

[0020] The ecdysteroid insecticides are: methoxyfenozide, fufenozide, furantebufenozide, halofenozide, chromafenozide, tebufenozide, RH-5849, flometoquin, protrifenbute;

[0021] The juvenile hormone insecticides are: pyriproxyfen, hydroprene, kinoprene, methoprene, triprene, antijuvenileene, epofenonane, juvenileyne, diofenolan, pyriproxyphenone, precocene Ⅰ, precocene Ⅱ, precocene Ⅲ, juvenile hormone Ⅰ, juvenile hormone Ⅱ, juvenile hormone Ⅲ.

[0022] The amide insecticides (B9) are selected from: flubendiamide, cyantraniliprole, cyantraniliprole, tetraniliprole, cyhalodiamide, thiotraniliprole, flursulamid, fenoxacrim, tolfenpyrad, cyclaniliprole, cyclaniliprole, broflanilide, cyproflanilide, triflumidamid, fluchlordiniliprole, tetrachlorantraniliprole, flubendiamide, cyantraniliprole, dimpropyridaz.

[0023] The nicotinic insecticides (B 10 ) are selected from: acetamiprid, thiamethoxam, clothianidin, thiacloprid, imidacloprid, nitenpyram, dinotefuran, cycloxaprid, guadipyr, flupyradifurone, sulfoxaflor, imidaclothiz, sulfoxaflor, paichongding, pyrifluquinazon, nicotine, anabasine, nornicotine, flupyrimin;

[0024] The insect feeding deterrent insecticides (B 11 ) are selected from pymetrozine, flonicamid, afidopyropen, afidopyropen, pyrifluquinazon, triflumidamid, fluhexafon, benzpyrimoxan, tyclopyrazoflor;

[0025] The fungicides (B 12)One or two selected from methoxyacrylate, triazole, pyrrole, amide, benzimidazole, substituted benzene, dithiocarbamate, organosulfur, oxazole fungicides.

[0026] Acaricide (B 13)Selected from: pyridaben, cyetpyrafen, fluacrypyrim, fenpyroximate, tebufenpyrad, cyenopyrafen, etoxazole, hexythiazox, clofentezine, propargite, bifenazate, cyflumetofen, azocyclotin, cyhexatin, fenbutatin oxide, phenproxide, benzoximate, triarathene, dofenapyn, halfenprox, chloropropylate, dienochlor, flubenzimine, tazimcarb, phostin, dicofol, tetradifon, chlorfenethol, tetrasul, tetranactin, medimeform, aramite, chlorfenson, chlorfensulphide, genite, MNFA, cycloprate, amidoflumet, fenazaflor, clenpirin, thioquinox, fenazaquin, binapacryl, fluenetil, dinocton, chlorbenside, cymiazole, morphothion, pyriminostrobin, pyrimidifen, acequinocyl, chinomethionat, chloromebuform, malonoben, bromocyclen, azobenzene, TEPP, dinosulfon, bromopropylate,Dinopenton, dinoterbon, prothidathion, dinex, dinobuton, chlorobenzilate, benoxafos, endosulfan, sulfur, DNOC, semiamitraz, amitraz, chlordimeform, formetanate, Flipper (biological acaricide containing C7-C20 fatty acids), pyflubumide, acynonapyr or trifluenfuronate;

[0027] Other insecticides and inorganic substances (B 14)Selected from: indoxacarb, metaflumizone, fluxametamide, isocycloseram; sulfluramid; nifluridide; plifenate; flupyradifurone; pyriprole; pyrafluprole; vaniliprole; nicofluprole; chlorfenapyr; brofenapyr; pyridalyl; acetoprole; dicloromezotiaz; fipronil; flufiprole; butaniliprole; dicyclanil; ethiprole; acetoprole; thiapronil; bromonitril; dicresyl; dilor; flupyroxystrobin; rafoxanide; nithiazine; flufenerim; sulfoxime; thiofluoximate; bromfenvinfos; mirex; methidathiazole; chloromethiuron; flufenerim; oxazosulfyl; kelevan; closantel; mercurous chloride; potassium thiocyanate; borax; boric acid; calcium arsenate; lead arsenate; potassium arsenite; barium hexafluorosilicate; chlordecone; isobenzan; bollex; isodrin; endrin, indazapyroxamet, fenmezoditiaz, anisiflupurin, tigolaner, sarolaner, fluralaner, afoxolaner, flupentiofenox, modoflaner, sulfiflumin;

[0028] Preferably, the active ingredient B in the binary insecticidal and acaricidal composition is preferably:

[0029] The nereistoxin insecticides (B1) are selected from cartap, bisultap, and monosultap;

[0030] The macrolide insecticides (B2) are selected from avermectin, abamectin, and emamectin benzoate;

[0031] The organophosphorus insecticides (B3) are selected from acephate, chlorpyrifos, diazinon, triazophos, malathion, and phoxim;

[0032] The carbamate insecticides (B4) are selected from carbosulfan and carbaryl;

[0033] The tetronic acid acaricides (B5) are selected from spirodiclofen, spirotetramat, spiromesifen, metoxadiazone, and spiroxamine;

[0034] The biogenic insecticides (B6) are selected from azadirachtin;

[0035] The pyrethroid insecticides (B7) are selected from bifenthrin, beta-cyfluthrin, fenpropathrin, beta-cypermethrin, lambda-cyhalothrin, gamma-cyhalothrin, cyfluthrin, esfenvalerate, cis-cypermethrin, transfluthrin, cypermethrin, ethofenprox, deltamethrin, pyrethrins, zeta-cypermethrin, fenvalerate, permethrin, and fenpropathrin;

[0036] The insect growth regulator insecticides (B8) are selected from chitin synthesis inhibitor insecticides: diflubenzuron, hexaflumuron, buprofezin, lufenuron, flufenoxuron, chlorfluazuron, novaluron, chlorbenzuron, diafenthiuron, and cyromazine; ecdysone hormone insecticides: methoxyfenozide, tebufenozide, and halofenozide; juvenile hormone insecticides: pyriproxyfen;

[0037] The amide insecticides (B9) are selected from flubendiamide, tetraniliprole, cyantraniliprole, and tolfenpyrad;

[0038] The nicotine insecticides (B 10 ) are selected from acetamiprid, thiamethoxam, clothianidin, thiacloprid, imidacloprid, nitenpyram, dinotefuran, and sulfoxaflor;

[0039] The insect feeding deterrent insecticides (B 11 ) are selected from pymetrozine, flonicamid, triflumezopyrim, and pyflubumide;

[0040] The fungicides (B 12 ) are selected from enostroburin, fludioxonil, metalaxyl-M, difenoconazole, tebuconazole, azoxystrobin, and pyraclostrobin;

[0041] The acaricides (B 13)Selected from pyridaben and etoxazole nitrile;

[0042] Other insecticides and inorganic substances (B 14 )Selected from metaflumizone, flutriafol, isoxazoline insectamide, fipronil, sulfiflumin, and modoflaner.

[0043] The preparation is one or more of a suspension concentrate, a suspo-emulsion, a microcapsule granule, a microcapsule suspension, a dispersible oil suspension, an emulsion in water, a soluble solution, a dispersible liquid, a tablet, a dispersible oil, an ultra-low volume agent, a powder, a wettable powder, a granule, a microemulsion, an emulsifiable concentrate, a water dispersible granule, an emulsifiable powder, an emulsifiable granule, a floating granule, an effervescent granule, an effervescent tablet, a sustained release granule, or an aerosol, a seed treatment dry powder, a seed treatment dispersible powder, a seed treatment liquid, a seed treatment emulsion, a seed treatment suspension concentrate.

[0044] The dosage form is preferably: a suspension concentrate, a suspo-emulsion, a dispersible oil suspension, an emulsion in water, a soluble solution, a wettable powder, a granule, a microemulsion, an emulsifiable concentrate, a water dispersible granule, a sustained release granule, a seed treatment suspension concentrate;

[0045] The adjuvants are one or more of a surface modification adjuvant, an emulsifier, a dispersant, a wetting agent, a binder, a stabilizer, an antifoaming agent, an antifreezing agent, a preservative, a penetrant, a thickening agent.

[0046] Preferably, the adjuvants are a surface modification adjuvant and one or more of an emulsifier, a dispersant, a wetting agent, a binder, a stabilizer, an antifoaming agent, an antifreezing agent, a preservative, a penetrant, a thickening agent.

[0047] An emulsifiable concentrate is a homogeneous transparent liquid formed by uniformly mixing the technical material, an organic solvent, and a surfactant. It usually contains 10 - 50% of the active ingredient, 2 - 20% of the emulsifier, 0 - 20% of other additives such as penetrants, etc., and the balance of the inert carrier.

[0048] A suspension concentrate is usually prepared by mixing the technical material, a surfactant, an antifreezing agent, and water, and then subjecting it to sand milling in a sand mill to obtain a stable non-settling flowable product. A suspension concentrate usually contains 5 - 75% of the active ingredient, 5 - 15% of the dispersant, 4 - 10% of the antifreezing agent, 0 - 10% of other additives such as antifoaming agents, preservatives, stabilizers, penetrants, and thickening agents, and the balance of the liquid carrier.

[0049] An emulsion in water is usually prepared by uniformly mixing the technical material, an organic solvent, and a surfactant to form an oil phase; mixing water and an antifreezing agent together to form a homogeneous transparent water phase. Using a high-shear emulsifier to shear the oil phase at high speed while slowly adding the water phase to the oil phase, a uniformly dispersed emulsion in water can be obtained. It usually contains 1 - 0% of the active ingredient, 5 - 20% of the emulsifier, 0 - 10% of other additives, such as penetrants, and the balance of the inert carrier.

[0050] Microemulsions are usually prepared by mixing the technical material, organic solvents, surfactants, and water to form a homogeneous and transparent liquid. They usually contain 1 - 50% active ingredient, 10 - 40% emulsifier, 2 - 10% antifreeze agent, 0 - 10% other additives such as penetrants, and the balance being inert carrier.

[0051] Soluble concentrates are prepared by mixing the active ingredient, organic solvents, and surfactants to form a homogeneous and transparent liquid. Usually, they contain 1 - 50% active ingredient, 6 - 20% surfactant, 0 - 10% other additives such as penetrants, and the balance being inert carrier.

[0052] Oil-based suspension concentrates are usually prepared by mixing the active ingredient, surfactants, and oil-based carriers and then grinding them in a sand mill until the particle size meets the requirements. They usually contain 2 - 60% active ingredient, 6 - 20% emulsifier, 0 - 10% other additives such as penetrants, and the balance being inert carrier.

[0053] Microcapsule suspensions are usually prepared by uniformly mixing the active ingredient, surfactants, and solvents to form an emulsion, then mixing it with a pre-prepared urea-formaldehyde resin prepolymer. Under stirring, the pH value is adjusted with an aqueous acid solution to form capsules and cure them. Then, the pH value of the system is adjusted to 7 with an aqueous alkali solution and water is added to make it uniform by stirring to obtain the microcapsule suspension. They usually contain 2 - 45% active ingredient, 5 - 15% dispersant, 5 - 30% other additives such as defoamers, preservatives, stabilizers, penetrants, and thickeners, and the balance being liquid carrier.

[0054] Granules are usually prepared by mixing the active ingredient and carrier, kneading, granulating, drying, and coating. They usually contain 0.1 - 10% active ingredient, 0 - 10% other additives such as binders, and the balance being inert carrier.

[0055] The manufacturing method of the slow-release pesticide granules of the present invention is not particularly limited, and general methods for manufacturing granules can be used, such as wet granulation, dry granulation, spray granulation, stirring granulation, extrusion granulation, etc. The preferred method is extrusion granulation, which is simple, easy to operate, and has low manufacturing costs.

[0056] Water dispersible granules are usually prepared by mixing the technical material, surfactants, and carriers, first grinding them to obtain a powder, and then kneading and granulating. They are usually made into granules with a size of 10 - 100 international standard mesh (1.676 - 0.152 mm) and can be prepared by extrusion, dipping, or spray granulation methods. Usually, water dispersible granules contain 5 - 75% active ingredient and 5 - 20% surfactants such as stabilizers, wetting and dispersing agents, disintegrants, and binders, and the balance being inert carrier.

[0057] Wettable powders are usually prepared by mixing the technical material, auxiliaries and carriers and then grinding them to obtain a powder substance, which usually contains 10 - 85% active ingredient, 3 - 10% dispersant, 0 - 10% other additives such as penetrants or adhesives, and the balance being an inert carrier.

[0058] Aqueous dispersions and emulsions (such as compositions obtained by diluting the emulsifiable concentrates, wettable powders or concentrates of the present invention with water) are also within the scope of the present invention. The above emulsions can be water-in-oil or oil-in-water type and can have a thick paste consistency.

[0059] In addition, the solid preparations in the present invention also include conventional solid preparations that can be prepared, such as tablets, powders, granules, floating granules, emulsifiable powders (or granules), effervescent granules (or tablets), microcapsule granules, sustained-release granules, etc.

[0060] The surface modification auxiliaries are selected from one or more of fluorinated polyacrylates, sulfosuccinates, modified alkoxylates (such as Efka SL 3030, Efka SL 3031, Efka SL 3034, Efka SL 3035, Efka SL 3039, etc.), silicone surfactants (such as Hydropalat WE 3220, Hydropalat WE 3225, etc.), alkoxylated surfactants (such as Hydropalat WE3120, Hydropalat WE 3165, Hydropalat WE 3189, etc.), star polymers (such as Hydropalat WE 3322, Hydropalat WE 3123, etc.).

[0061] Suitable liquid carriers or solvents can be water, various aromatic hydrocarbons, aliphatic hydrocarbons, ketones, ethers, etc., such as toluene, xylene, acetone, cyclohexanone, acetonitrile, benzene, cyclohexane, isopropanol, ethylene glycol, sorbitol, methanol, ethanol, butanol, dimethylformamide, dimethyl sulfoxide, N-methyl-pyrrolidone, cyclohexanone, tributyl phosphate, methyl isobutyl ketone, decalin, machine oil, petroleum ether, methyl oleate, methylated soybean oil or methyl cellosolve, etc., and one or more of them. Mixtures of different liquids are often suitable.

[0062] Suitable solid carriers include natural or synthetic clays and silicates. Solid carriers suitable for powders include naturally formed rock powders, chalk, quartz, clay, montmorillonite, sodium sulfate, precipitated silica, silica, silica sand, diatomaceous earth, pumice, gypsum, talc, bentonite, kaolin, attapulgite, light calcium carbonate, pottery clay and synthetic ground minerals (such as finely dispersed silicic acid or alumina). Suitable particulate carriers include crushed and graded natural rocks such as calcite, marble, pumice, sepiolite and dolomite and synthetic granules made from powders of organic and inorganic substances.

[0063] Suitable cosolvents include one or more of methanol, phenol, isopentyl alcohol, tributyl phosphate, ethyl acetate, methyl ethyl ketone, dimethylformamide, methyl sulfoxide, N-methyl-pyrrolidone, methyl oleate, methyl isobutyl ketone, methyl cellosolve, Solvesso 100, Solvesso 200, etc.

[0064] Suitable emulsifiers can be ethoxylated castor oil, polyoxyethylene(n 20 ) ethylphenol ether oleate alkylaryl polyoxyethylene polyoxypropylene ether, alkylaryl formaldehyde resin polyoxyethylene ether, triphenylvinylphenol polyoxyethylene(n 20 ) ether phosphorylated triethanolamine salt, castor oil polyoxyethylene ether, alkyl vinyl aryl phenyl ether (YUS-SC3) diphenylphenol polyoxyethylene(n) formaldehyde condensate, calcium isothiocyanate oleate agricultural emulsion AEO-3, agricultural emulsion 0201B, agricultural emulsion 0203B, agricultural emulsion T-20, agricultural emulsion T-85, agricultural emulsion S-80, agricultural emulsion 507#, agricultural emulsion 100#, agricultural emulsion 36#, agricultural emulsion 500#, agricultural emulsion 600#, agricultural emulsion 700#, agricultural emulsion 1601#, agricultural emulsion 0X-2681, agricultural emulsion 0X-8686, agricultural emulsion 2201#, agricultural emulsion NP-7, agricultural emulsion 0X-635, agricultural emulsion 0X-653, agricultural emulsion YUS-D935, agricultural emulsion YUS-CP120, agricultural emulsion YUS-A41B, agricultural emulsion YUS-D3020, agricultural emulsion NP-10, agricultural emulsion NP-15, etc.

[0065] Suitable dispersants can be sodium lignin sulfonate, calcium lignin sulfonate, sodium salt of alkyl naphthalene sulfonic acid polycondensate, polycarboxylate dispersant, sodium naphthalene sulfonate formaldehyde condensate, sodium salt of naphthol sulfonic acid formaldehyde condensate, methyl naphthalene sulfonic acid formaldehyde condensate, alkyl-diethylene glycol ether-sodium sulfonate, N-methyl-oleyl-sodium taurine, detergent LS, sodium methylene naphthalene sulfonate, sodium oleic acid methylaminoethyl sulfonate, epoxy polyether, dispersant SP-28F, dispersant SP-SC3, Darun dispersant D909S, alkyl aryl polyoxyethylene ether, dodecyl polyoxyethylene ether phosphate, polyaryl phenol polyoxyethylene ether, p-tert-butyl ether, piperonyl butoxide, alkyl amide taurate, alkyl naphthalene sulfonate formaldehyde condensate Compound (NNO), ethylene oxide-propylene oxide segment copolymer alkylphenol polyoxyethylene ether formaldehyde condensate, N-methyl-fatty acyl-sodium sulfonate, alkylphenol polyoxyethylene ether formaldehyde condensate, sodium dibutylnaphthalene sulfonate (Lakai powder BX) dibutylnaphthalene sulfonic acid formaldehyde condensate, alkylphenol polyoxyethylene ether formaldehyde condensate sulfate, alkylphenol polyoxyethylene phosphate, dispersant YUS-NV1203, dispersant YUS-NV1420, dispersant YUS-WG4, dispersant YUS-TG285, dispersant YUS-WP1, dispersant YUS-110, dispersant YUS-EP60P, dispersant YUS-CH1100, etc., one or more thereof.

[0066] Suitable wetting agents may be one or more of sodium sulfate, Morwet EFW, wetting agent SP-SC3266, wetting agent YUS-SXC, wetting agent YUS-204, sodium isopropyl naphthalene sulfonate, sodium alkyl alcohol polyvinyl ether sulfate, alkylphenol polyhydrogen vinyl ether formaldehyde condensate sulfate, sodium lauryl sulfate, sodium dodecylbenzene sulfonate, sodium dodecyl sulfate, calcium dodecylbenzene sulfonate, sodium alkyl tea sulfonate, fatty alcohol polyoxyethylene ether, alkylphenol polyoxyethylene ether, and the like.

[0067] Suitable thickeners can be synthetic (such as methyl alcohol, polyvinyl alcohol, polyvinyl acetate, LT-908) or natural water-soluble polymers (such as xanthan gum, gelatin, gum arabic, polyvinyl pyrrolidone, magnesium aluminum silicate, polyvinyl alcohol, polyethylene glycol, phenolic resin, shellac, methyl cellulose, soluble starch, carboxymethyl cellulose and sodium alginate, etc.), and are added to the preparation in the form of powder, granules or latex.

[0068] The wall materials are: natural polymer materials, such as gelatin, gum arabic, agar, alginate, chitosan, fibrin, zein, etc.; semi-synthetic polymer materials, such as methyl (ethyl) cellulose, methyl cellulose (sodium) acetate cellulose and its esters and some glycerides, etc.; fully synthetic polymer materials, such as one or more of polyacrylic resin, polylactic acid, melamine resin, urea-formaldehyde resin, polyamide, polyester, polymethyl methacrylate, polyurea, polyurethane, etc.

[0069] Suitable defoamers include antifoam A, silicone-based compounds, C 8～10 fatty alcohols, phosphate esters C 10～20 saturated fatty acids (such as capric acid) and amides, SAG1522, SAG1572, GY-007, etc., or one or more of them.

[0070] Suitable preservatives can be selected from sodium benzoate, Kathon (2-methyl-4-isothiazolin-3-one and (B) 5-chloro-2-methyl-4-isothiazolin-3-one), potassium sorbate, sodium dehydroacetate, morpholine derivatives (Nipacide MBM), triazine derivatives (Nipacide BK), benzisothiazolinone (Nipacide BIT20), chlorine-containing and non-chlorine-containing methylisothiazolinone (Nipacide CI), EQ or others, or one or more of them.

[0071] Suitable binders can be one or more of polyvinyl alcohol, polyvinyl acetate, xanthan gum, gelatin, carboxymethyl cellulose, and sodium alginate.

[0072] Application in a binary insecticidal and acaricidal composition formulation, and application of the formulation in the control of pests, mites or hygienic pests on ornamental plants, fruit trees, vegetables, cotton, flowers, tea and cereal crops.

[0073] According to its action target and application method, the present invention has developed a formulation containing compound A by searching for adjuvant varieties matching the active ingredients, so as to achieve the purpose of improving the transfer efficiency of the active ingredients in the processes of atomization, deposition, attachment and spreading, penetration and absorption, and conduction from application to the target and its growth medium. By increasing the retention amount, prolonging the retention time and enhancing the permeability of the pesticide active ingredients on the plant surface, the bioavailability and effective utilization efficiency of the pesticide are improved.

[0074] The invention obtains a binary insecticide and acaricide composition preparation containing compound A through good synergistic compatibility of auxiliary agents and optimal preparation process route and conditions. The binary insecticide and acaricide composition preparation has the characteristics of good dispersibility, high suspension rate, high bioavailability, good biological activity, small dosage, low cost, good environmental compatibility, etc., and has the following advantages compared with the known preparations: 1) the solvent used in the emulsifiable concentrate of the invention is green and environmentally friendly, and has good wettability and spreading ability when it is prepared into an emulsion by adding water and sprayed on crops or harmful organisms; 2) the wettable powder of the invention disintegrates quickly in water, has good wettability, less foam, good physical stability, and convenient packaging, storage and transportation; 3) the suspension of the invention has low viscosity, is convenient for production canning and pouring during use, has high sand grinding efficiency, has finer particle size of the output under the same production conditions, and has better efficacy within a certain range. Good stability, can form a stable suspension liquid, not easy to precipitate, suitable for long-distance transportation and storage; 4) The dispersible oil suspension of the present invention not only has good dispersibility, stable performance, better adhesion, larger deposition amount, obvious synergistic effect on the target, more effective drug effect, but also has little pollution to the environment, is safe for humans, livestock, birds and beneficial organisms, and is more conducive to protecting the ecological balance; 5) The microcapsule suspension of the present invention has a long lasting effect, slow / controlled release of the active components of the pesticide after application, achieving a good combination of quick effect and lasting effect, thereby achieving the purpose of reducing the number of times and the amount of medication, improving the utilization rate of the effective ingredients, and is conducive to saving labor and energy. DETAILED DESCRIPTION

[0075] The following specific examples are used to further illustrate the present invention, which includes but is not limited to these examples. Methods well known to those skilled in the art are all within the scope of the present invention. The percentages in all formulation ratios are weight percentages, and the active ingredients are calculated as effective content.

[0076] Preparation formula example

[0077] Example 1 30% Compound A·Methafluzin wettable powder preparation (2:1)

[0078] 20% of compound A, 10% of cyanoflumizone, 2% of Morwet EFW, 4% of Ultrazine NA, 4% of Dispersogen WGN, 2% of white carbon black HL-200, 2% of fluorinated polyacrylate and calcined kaolin are added, fully mixed and crushed with an ultrafine grinder to obtain a 30% compound A·cyanoflumizone wettable powder.

[0079] Example 2 24% Compound A·Insecticidal single suspension concentrate (1:5)

[0080] Mix 4% of Compound A, 20% of monosultap, 2% of D-305, 4% of DA1349, 1% of DS569, 2% of Hydropalat WE3322, 4% of ethylene glycol, 0.2% of xanthan gum, 0.2% of EQ, 1% of 1522 and 20% of magnesium aluminum silicate A, and make up the balance with water to 100%. Add them into a sand mill kettle and grind finely to obtain a 24% Compound A·monosultap suspension concentrate.

[0081] Monosultap can also be replaced with cartap or dimehypo described in this specification to form new examples.

[0082] Example 3: 20% Compound A·abamectin emulsion in water (1:1)

[0083] Add 10% of Compound A, 10% of abamectin, 5% of AEO-9, 8% of S-20, 1% of sulfosuccinate, 1% of T-80, 4% of ethylene glycol, 2% of polyethylene glycol, 1% of 1522 and 25% of dimethylacetamide into a mixer, stir and mix to dissolve them into a homogeneous oil phase. Under high-speed stirring, make up the balance with water to 100% and add it to the oil phase to obtain a 20% Compound A·abamectin emulsion in water.

[0084] Example 4: 30% Compound A·emamectin benzoate emulsifiable concentrate (1:1)

[0085] Add 15% of Compound A, 15% of emamectin benzoate, 20% of Genagen NBP, 15% of SV-17, 1% of D865, 3% of Synergen 848, 1% of Hydropalat WE 3120, 15% of Solvesso 150 to 100% and add them into a mixing kettle. Stir and disperse until it is clear and transparent. Heat and dissolve if necessary to obtain a 30% Compound A·emamectin benzoate emulsifiable concentrate.

[0086] Example 5: 24% Compound A·chlorpyrifos emulsion in water (5:1)

[0087] Add 20% of Compound A, 4% of chlorpyrifos, 3% of SK-5935, 5% of 700#, 1% of NP-10P, 4% of propylene glycol, 2% of fluorinated polyacrylate, 1% of 1522, 8% of cyclohexanone and 30% of dimethylacetamide into a mixer, stir and mix to dissolve them into a homogeneous oil phase. Under high-speed stirring, make up the balance with water to 100% and add it to the oil phase to obtain a 24% Compound A·chlorpyrifos emulsion in water.

[0088] Chlorpyrifos can also be replaced with acephate and triazophos described in this specification to prepare a 24% Compound A·acephate emulsion in water and a 24% Compound A·triazophos emulsion in water.

[0089] Example 6 60% Compound A·Malathion Water Dispersible Granules (1:1)

[0090] Mix 30% Compound A, 30% malathion, 4% YUS-RXB, 2% Hydropalat WE 3225, 2% Soprophor FD, 4% YUS-WG1, 2% Geropon Ultrasperse, and make up to 100% with bentonite. Mix and pulverize, then knead with water added, and add into a granulator equipped with a certain specification sieve for granulation. Then, through drying and screening (according to the sieve range), 60% Compound A·Malathion Water Dispersible Granules can be obtained.

[0091] With the same above formula, malathion can be replaced by diazinon or phoxim to prepare 60% Compound A·Diazinon Water Dispersible Granules and 60% Compound A·Phoxim Dispersible Granules respectively.

[0092] Example 7 20% Compound A·Spirodiclofen Dispersible Oil Suspension Concentrate (1:3)

[0093] Mix 5% Compound A, 15% spirodiclofen, 5% agricultural emulsifier 0203B, 15% 96DB10, 5% D800, 1% Efka SL3039, 4% glycerol, 1% white carbon black, 1% organic bentonite, and the balance methyl oleate (make up to 100%). First, carry out coarse pulverization and homogenization through high shear, then enter a sand mill for fine grinding. Use a particle size distribution analyzer to detect the particle size of the sand-milled material. After the particle size meets the standard requirements, filter to obtain 20% Compound A·Spirodiclofen Dispersible Oil Suspension Concentrate.

[0094] With the same above formula, spirodiclofen can also be replaced by one of the acetyl-CoA carboxylase inhibitor insecticidal / acaricidal agents described in this specification to form a new 20% Compound A·Acetyl-CoA Carboxylase Inhibitor Insecticidal / Acaricidal Agent Dispersible Oil Suspension Concentrate.

[0095] Example 8 6% Compound A·Fludioxonil Microemulsion (1:5)

[0096] Add 1% Compound A, 5% fludioxonil, 5% agricultural emulsifier 0201B, 2% sulfosuccinate, 4% 600#, 1% 500#, 10% cyclohexanone, 10% water, 4% ethylene glycol, and the balance triethyl phosphate (make up to 100%) into a mixer, stir and mix to dissolve into a homogeneous liquid, then 6% Compound A·Fludioxonil Microemulsion with good dispersibility can be obtained.

[0097] Example 9 18% Compound A·Carbosulfan Suspension Concentrate (5:1)

[0098] Mix 15% of Compound A, 3% of carbosulfan, 2% of Efka SL 3030, 3% of carboxylate dispersant SP-27001, 2% of sulfonate anionic dispersant SK20TX, 2% of sulfate dispersant SK-34SC, 1.6% of LT-908, 0.6% of magnesium aluminum silicate B, 4% of ethylene glycol, 0.8% of SAG-1572, 0.2% of EQ, and make up the balance with water to 100%. Add them into a sand mill kettle and grind finely to obtain 18% Compound A·carbosulfan suspending agent.

[0099] Carbosulfan can also be replaced with carbaryl or fenobucarb in this specification, and the types and dosages of carboxylate, sulfonate and corresponding sulfate auxiliaries are adjusted to prepare 20% Compound A·carbaryl suspending agent (1:1) and 22% Compound A·fenobucarb suspending agent (10:1).

[0100] Example 10 10% Compound A·beta-cyfluthrin soluble concentrate (1:1)

[0101] Mix 5% of Compound A, 5% of beta-cyfluthrin, 15% of agricultural emulsifier 600#, 6% of agricultural emulsifier 507#, 1% of Efka SL3039, 6% of T-20%, 12% of dimethylformamide, 25% of dimethyl sulfoxide, 26% of methanol, and heat with a hot water bath when necessary to dissolve it into a homogeneous liquid, then 10% Compound A·beta-cyfluthrin soluble concentrate can be obtained.

[0102] Example 11 20% Compound A·bifenthrin suspending agent (1:1)

[0103] Mix 10% of Compound A, 10% of bifenthrin, 10% of carboxylate dispersant SF-133, 2% of sulfosuccinate, 1% of alkylnaphthalene sulfonic acid condensate agent Morwet D-425, 2% of polyacrylic acid polymer Agrilan 700, 4% of urea, 0.2% of xanthan gum, 0.6% of BIT-20, 0.6% of fumed silica, and make up the balance with water to 100%. After high-speed shearing, wet sand grinding, and finally homogeneous filtration, 20% Compound A·bifenthrin suspending agent can be obtained.

[0104] Using the same above formula, replace bifenthrin with other pyrethrins or pyrethroids, and adjust the types and dosages of wetting dispersants to correspondingly prepare 20% Compound A·pyrethrin or pyrethroid suspending agent.

[0105] Example 12 22% Compound A·fluxapyroxad suspending agent (10:1)

[0106] 20% of Compound A, 2% of fluxametamide, 2% of lignosulfonate Ultrazine NA, 1% of Hydropalat WE 3123, 3% of carboxylate dispersant DS809, 2% of phosphate polyether Featdis DCP, 0.2% of xanthan gum, 4% of propylene glycol, 0.6% of BIT-20, 1% of SXP830, 0.8% of LT-908, and the balance of water to make up 100%. After shear wet grinding and finally homogenizing and filtering, a 22% Compound A·fluxametamide suspension concentrate product can be obtained.

[0107] Example 13 22% Compound A·isoxazolinon EC (10:1)

[0108] 20% of Compound A, 2% of isoxazolinon, 2% of agricultural emulsion 0201B, 2% of sulfosuccinate, 8% of agricultural emulsion 0203B, 7% of AEO-3, 10% of N-methylpyrrolidone, and the balance of S-200 (to make up 100%) are added to a mixing kettle and stirred and mixed to dissolve into a homogeneous oil phase, thus obtaining a 22% Compound A·isoxazolinon EC with good dispersibility.

[0109] Example 14 11% Compound A·fipronil slow-release granule (10:1)

[0110] 10% of Compound A, 1% of fipronil, 2% of sodium dodecyl sulfate, 1% of Efka SL 3034, 11% of naphthalene sulfonate formaldehyde condensate, 4% of calcium dodecyl sulfate, 17% of bentonite, 2% of hydroxyethyl cellulose aqueous solution, and kaolin to make up 100% are mixed, and then subjected to air-flow pulverization, kneading, granulation, drying, screening (according to the sieve mesh range), and finally coated with a coating material to obtain an 11% Compound A·fipronil slow-release granule.

[0111] Example 15 10% Compound A·flufenoxuron SC (1:1)

[0112] 5% of Compound A, 5% of flufenoxuron, 3% of block copolymer Genapol PF40, 1% of sulfosuccinate, 2% of YUS-D3020, 2% of DS528, 4% of ethylene glycol, 2% of LT-908, 0.2#EQ, and the balance of water to make up 100%. After shear wet grinding, and finally homogenizing and filtering, a 10% Compound A·flufenoxuron SC can be obtained.

[0113] Flufenoxuron can be replaced with other chitin synthesis inhibitor insecticides, such as: diflubenzuron, hexaflumuron, lufenuron, tralomethrin, chlorfluazuron, chlorbenzuron, diafenthiuron, etc., to obtain a 10% Compound A·chitin synthesis inhibitor insecticide SC.

[0114] Example 16 20% Compound A·methoxyfenozide EC (1:1)

[0115] Add 10% of Compound A, 10% of methoxyfenozide, 15% of T-80, 4% of 700#, 1% of Hydropalat WE 3189, 1% of 500#, 20% of dimethylacetamide, and the balance of SV-92 (to make up 100%) into a mixer, stir and mix them to dissolve into a uniform liquid, then 10% Compound A·methoxyfenozide emulsifiable concentrate can be obtained.

[0116] Example 17 20% Compound A·furametpyr aqueous emulsion (1:1)

[0117] Add 10% of Compound A, 10% of furametpyr, 5% of agricultural emulsion 0203B, 3% of SK551, 2% of sulfosuccinate, 10% of S-150, 22% of Rhodiasolv Green 25, 4% of ethylene glycol, 0.8% of SAG-1522 into a mixer, stir and mix them to dissolve into a uniform oil phase. Under high-speed stirring, add the balance of water to make up 100% to the oil phase, then 20% Compound A·furametpyr aqueous emulsion can be obtained.

[0118] Example 18 20% Compound A·tebufenozide emulsifiable concentrate (1:1)

[0119] Add 10% of Compound A, 10% of tebufenozide, 10% of 600#, 1% of Hydropalat WE 3165, 10% of agricultural emulsion 0201B, 10% of cyclohexanone, and the balance of dimethylacetamide (to make up 100%) into a mixing kettle, stir and mix them to dissolve into a uniform liquid, then 20% Compound A·tebufenozide emulsifiable concentrate can be obtained.

[0120] Example 19 10% Compound A·cyromazine microemulsion (1:1)

[0121] Add 5% of Compound A, 5% of cyromazine, 10% of Rhodiasolv DIB, 2% of sulfosuccinate, 2% of 700#, 3% of Agrilan 755, 8% of Ethylan NS-500LQ into a mixer, stir and mix them to dissolve into a uniform liquid, then 10% Compound A·cyromazine microemulsion can be obtained.

[0122] Example 20 15% Compound A·pyriproxyfen wettable powder (1:1)

[0123] Add 7.5% of Compound A, 7.5% of pyriproxyfen, 4% of Dispersogen SI, 4% of Hydropalat WE 3225, 4% of SK-21K, 8% of corn starch, and make up to 100% with kaolin, mix thoroughly, and then obtain 15% Compound A·pyriproxyfen wettable powder after pulverizing with an ultrafine pulverizer.

[0124] Example 21 20% Compound A·Buprofezin Suspension Concentrate (1:3)

[0125] Mix 5% Compound A, 15% buprofezin, 2% SK-92FS1, 3% YUS-FS3000, 2% fluorinated polyacrylate, 2% Agrilan 755, 1% magnesium aluminum silicate NM-178D, 0.2% xanthan gum, 4% ethylene glycol, 0.6% Atlox 3772, 0.3% Nipacide BK, and make up the balance with water to 100%. After shear wet grinding and finally homogeneous filtration, 20% Compound A·Buprofezin Suspension Concentrate can be obtained.

[0126] Example 22 2% Compound A·Tetramethrinamide Microcapsule Suspension Concentrate (1:1)

[0127] Mix 1% Compound A, 1% tetramethrinamide, and 8% dimethylacetamide completely to dissolve into a homogeneous oil phase. Shear it with an aqueous solution containing 0.6% toluene diisocyanate, 4% Atlox100A, 4% Atlox 100B, 3% Ethylan 324, 1% Efka SL3039, and 1% Morwet IP. Then add 0.2% ammonia water, 0.1% sulfuric acid aqueous solution, 4% ethylene glycol, 0.6% Atlox 3772, 0.2% EQ, 0.2% xanthan gum, and make up the balance with water to 100%. Stir and mix. After the reaction is complete, continue to stir and carry out heat preservation and curing to obtain 2% Compound A·Tetramethrinamide Microcapsule Suspension Concentrate.

[0128] Example 23 20% Compound A·Cyantraniliprole Emulsion in Water (1:3)

[0129] Add 5% Compound A, 15% cyantraniliprole, 3% T-20, 15% SV-33, 2% fluorinated polyacrylate, 15% methylnaphthalene, 4% Atlox 4916, 5% propylene glycol, and 0.8% SAG-1522 to a mixer, stir and mix to dissolve into a homogeneous oil phase. Under high-speed stirring, make up the balance with water to 100% and add it to the oil phase to obtain 20% Compound A·Cyantraniliprole Emulsion in Water.

[0130] Cyantraniliprole can be replaced with flubendiamide or tolfenpyrad described in this specification to form new examples.

[0131] Example 24 20% Compound A·Clothianidin Suspension Concentrate (1:3)

[0132] Mix 5% of Compound A, 15% of clothianidin, 3% of Atlox 4894, 3% of sulfosuccinate, 4% of Atlox4913, 2% of Synperonic T / 304, 4% of ethylene glycol, 0.2% of xanthan gum, 1% of SF04, 0.6% of BIT-20, 1% of SXP830, and make up to 100% with water. After shear wet grinding and finally homogenizing and filtering, a suspending agent product can be obtained.

[0133] Example 25: 22% Compound A·acetamiprid emulsion in water (10:1)

[0134] Mix 20% of Compound A, 2% of acetamiprid, 3% of Synperonic PE / F 127, 3% of Atlax G-5000, 1% of sulfosuccinate, 3% of T-20, 15% of SV-92, 17% of SV-17, 5% of propylene glycol, and 0.8% of SAG-1522 in a mixer, stir and mix to dissolve them into a homogeneous oil phase. Under high-speed stirring, make up the remaining water to 100% and add it to the oil phase to obtain a 22% Compound A·acetamiprid emulsion in water.

[0135] Acetamiprid can be replaced with thiamethoxam to form a new example.

[0136] Example 26: 60% Compound A·nitenpyram water dispersible granule (1:3)

[0137] Mix 15% of Compound A, 45% of nitenpyram, 4% of xylooligosaccharide, 4% of Hydropalat WE 3189, 5% of YUS-WG5, 3% of Morwet D-110, 1% of SXP830, and make up the remaining light calcium carbonate to 100%. Mix and pulverize, then knead with water, and add it to a granulator equipped with a certain specification sieve mesh for granulation. Then, after drying and screening (according to the sieve mesh range), a 60% Compound A·nitenpyram water dispersible granule can be obtained.

[0138] Nitenpyram can be replaced with pymetrozine described in this specification to form a new example.

[0139] Example 27: 18% Compound A·dinotefuran suspending agent (5:1)

[0140] Mix 15% of Compound A, 3% of dinotefuran, 3% of Atlax G-5000, 4% of Atlox 4913, 3% of fluorinated polyacrylate, 2% of DS809, 1% of magnesium aluminum silicate, 0.2% of xanthan gum, 4% of urea, 0.6% of Atlox 3772, 0.3% of NipacideBK, and make up the remaining water to 100%. After shear wet grinding and finally homogenizing and filtering, an 18% Compound A·dinotefuran suspending agent can be obtained.

[0141] Dinotefuran can be replaced with sulfoxaflor described in this specification to form a new example.

[0142] Example 28 22% Compound A·Imidacloprid Dispersible Oil Suspension Concentrate (1:10)

[0143] Mix 2% Compound A, 20% imidacloprid, 9% Atlax G-1086, 2% Atlox 4914, 3% sulfosuccinate, 2.5% organic bentonite and methyl oleate (up to 100%). First, perform rough crushing and homogenization through high shear, then enter a sand mill for fine grinding. Use a particle size distribution analyzer to detect the particle size of the sand milled material. After the particle size meets the standard requirements, filter to obtain 22% Compound A·Imidacloprid Dispersible Oil Suspension Concentrate.

[0144] Imidacloprid can be replaced with thiacloprid described in this specification to form a new example.

[0145] Example 29 20% Compound A·Flonicamid Suspension Concentrate (1:1)

[0146] Mix 10% Compound A, 10% flonicamid, 4% XUS-D787, 2% SK-24N, 3% Hydropalat WE3120, 2% AG-TP1, 1% LT-908, 0.2% xanthan gum, 4% propylene glycol, 0.4% SAG-1572, 0.3% Nipacide BK and water up to 100%. After shear wet sand milling and finally homogenizing and filtering, 20% Compound A·Flonicamid Suspension Concentrate can be obtained.

[0147] Flonicamid can be replaced with pyfluquinazon described in this specification, and adjust the type and dosage of wetting and dispersing agents to form a new example

[0148] Example 30 10.5% Compound A·Triflumezopyrim Suspension Concentrate (1:20)

[0149] Mix 0.5% Compound A, 10% triflumezopyrim, 2% MNS / 90, 3% D100, 3% SP-SC29, 4% Hydropalat WE 3225, 4% ethylene glycol, 0.8% Kathon, 0.6% GX-007, 1% PVP-K30, 1.2% LT-908 and water up to 100%. After shear wet sand milling and finally homogenizing and filtering, 10.5% Compound A·Triflumezopyrim Suspension Concentrate can be obtained.

[0150] Example 31 22% Compound A·Enestroburin Dispersible Oil Suspension Concentrate (10:1)

[0151] Mix 20% of Compound A, 2% of enestroburin, 2.5% of Atlax 4915, 2.5% of Atlox LP-1, 1% of sulfosuccinate, 0.8% of Tween24, 3.5% of organobentonite and mineral oil (up to 100%). First, conduct rough crushing and homogenization through high shear, and then enter a sand mill for fine grinding. Use a particle size distribution analyzer to detect the particle size of the sand-milled material. After the particle size meets the standard requirements, filter to obtain a 22% Compound A·enestroburin dispersible oil suspension concentrate.

[0152] Enestroburin can be replaced with fludioxonil described in this specification, and the types and dosages of water-based and oil-based dispersants can be adjusted to form a new example.

[0153] Example 32: 30% Compound A·mefenoxam microemulsion (5:1)

[0154] Mix 25% of Compound A, 5% of mefenoxam, 25% of Atplus310, 3% of 0201B, 1% of sulfosuccinate, and 4% of propylene glycol in a mixer, stir and mix to dissolve them into a homogeneous oil phase. Under high-speed stirring, add the remaining water up to 100% to the oil phase to obtain a 30% Compound A·mefenoxam microemulsion.

[0155] Example 33: 20.5% Compound A·difenoconazole water emulsion (40:1)

[0156] Mix 20% of Compound A, 0.5% of difenoconazole, 3% of Tensiofix XA265, 2% of Hydropalat WE3165, 3% of Tensiofix EW 70, 12% of Solvesso 100, 15% of Solvesso 200, 5% of propylene glycol, and 0.8% of GY-007 in a mixer, stir and mix to dissolve them into a homogeneous oil phase. Under high-speed stirring, add the remaining water up to 100% to the oil phase to obtain a 20.5% Compound A·difenoconazole water emulsion.

[0157] Example 34: 21% Compound A·tebuconazole suspension concentrate (20:1)

[0158] Mix 20% of Compound A, 1% of tebuconazole, 2% of TENSIOFIX DB08, 1.5% of Hydropalat WE 3123, 1.5% of TENSIOFIX SC, 3% of SP-SC29, 4% of glycerol, 0.4% of Proxel GXL, 0.5% of TENSIOFIX 821, 0.6% of TENSIOFIX LO51, 1% of PVP-K30 and water up to 100%. After shear wet sand grinding and finally homogenization and filtration, a 21% Compound A·tebuconazole suspension concentrate can be obtained.

[0159] Tebuconazole can be replaced with the azoxystrobin described in this manual, and the type and amount of the wetting and dispersing agent can be adjusted to form a new example

[0160] Example 35 22% Compound A·Pyraclostrobin seed treatment suspension (10:1)

[0161] 20% compound A, 2% pyraclostrobin, 5% DS569, 3% DS809, 2% D305, 1% sulfosuccinate, 4% ethylene glycol, 0.2% xanthan gum, 0.5% kason, 0.8% TENSIOFIX LO51, 1% white carbon black and water are added to 100%, and the mixture is subjected to shear wet sand grinding and finally homogenized filtration to obtain a 22% compound A·pyraclostrobin seed treatment suspension.

[0162] Example 36 33% Compound A·Pyridaben wettable powder (1:10)

[0163] 3% of compound A, 30% of pyridabenzone, 8% of TENSIOFIX LX SPECIAL, 4% of sulfosuccinate, 3% of TENSIOFIX SC, 1% of TENSIOFIX DP400, 0.6% of TENSIOFIX CJK and kaolin are added to make up to 100%, mixed thoroughly and pulverized with an ultrafine grinder to obtain a 33% compound A·pyridabenzone wettable powder.

[0164] Example 37 42% Compound A·Ethiophanate suspension (1:20)

[0165] 2% compound A, 40% ethazofonil, 3% GY-D07, 3% GY-DS1287, 1% fluorinated polyacrylate, 4% urea, 0.2% xanthan gum, 0.5% BIT20, 0.8% magnesium aluminum silicate, 1% white carbon black and water are added to 100%, and the mixture is subjected to shear wet sand grinding and finally homogenized filtration to obtain a 42% compound A·ethazofonil suspension.

[0166] The particle size of the tested products is compared with the prior art suspension as shown in Table 1. The results show that the particle size of Example 37 is significantly larger than that of the commercially available suspension product (30% ethazofenyl suspension, trade name )Small.

[0167] Description: Particle size D50: The particle size corresponding to when the cumulative particle size distribution percentage of a sample reaches 50%. Its physical meaning is that 50% of the particles are larger than it and 50% of the particles are smaller than it. D50 is also called the median diameter or median particle size. D50 is often used to represent the average particle size of powders. Particle size D97: The particle size corresponding to when the cumulative particle size distribution number of a sample reaches 97%. Its physical meaning is that 97% of the particles are smaller than it. D97 is often used to represent the particle size index at the coarser end of the particles. The smaller the values of particle sizes D50 and D97, the finer the particle particles, and the more excellent the drug efficacy within a certain range.

[0168] Table 1 Particle Size Comparison

[0169] Example 38 18% Compound A·sulfiflumin Suspension Concentrate (1:5)

[0170] Mix 3% Compound A, 15% sulfiflumin, 3% Tersperse 2510, 5% SF133, 1.5% Hydropalat WE 3322, 4% ethylene glycol, 1.2% LT-908, 0.5% Nipacide BK, 1% silica white, and make up the balance to 100% with water. After shear wet sand grinding and finally homogeneous filtration, 18% Compound A·sulfiflumin Suspension Concentrate can be obtained.

[0171] Example 39 18% Compound A·modoflaner Suspension Concentrate (5:1)

[0172] Mix 15% Compound A, 3% modoflaner, 3% SP-27001, 2% TENSIOFIX DB08, 3% Efka SL3031, 1% D305, 4% ethylene glycol, 0.2% xanthan gum, 0.5% Nipacide BK, 1% magnesium aluminum silicate, and make up the balance to 100% with water. After shear wet sand grinding and finally homogeneous filtration, 18% Compound A·modoflaner Suspension Concentrate can be obtained.

[0173] Example 40 24% Compound A·avermectin Emulsion in Water (3:1)

[0174] Add 18% of Compound A, 6% of abamectin, 3% of YUS-D935, 2% of Ethylan NS-500LQ, 1% of Efka SL3034, 3% of SK-92FS1, 4% of glycerol, 0.8% of SAG-1522, 15% of Genagen 4296, and 17% of ARMID DM10 to a mixer, stir and mix them to dissolve into a uniform oil phase. Under high-speed stirring, make up the balance with water to 100% and add it to the oil phase to obtain 24% Compound A·abamectin aqueous emulsion.

[0175] Example 41 11% Compound A·azadirachtin suspension concentrate (10:1)

[0176] Add 10% of Compound A, 1% of modoflaner, 3% of DA1349, 2% of D800, 2% of Hydropalat WE 3120, 1% of TENSIOFIX SC, 4% of ethylene glycol, 0.2% of xanthan gum, 0.3% of EQ, 1% of aluminum magnesium silicate, and make up the balance with water to 100%. After shear wet grinding and finally homogeneous filtration, 11% Compound A·azadirachtin suspension concentrate can be obtained.

[0177] Example 42 Comparative experiment on the stability of suspension concentrate

[0178] Test the stability of the insecticidal and acaricidal preparations of the present invention, and at the same time conduct a comparative test with Compound A prepared by the method mentioned in CN112457288 B as the active ingredient in the control preparation. The test results are shown in Table 2.

[0179] Preparation of the control preparation: Mix the active ingredient compounds in the corresponding examples according to their ratios, then dissolve them with acetone (the content of acetone in the total solution does not exceed 10%), and then prepare a solution with the required concentration with 0.1% Tween 80 aqueous solution.

[0180] Table 2. Results of comparative experiment on stability (room temperature)

[0181]

[0182] It can be seen from Table 2 that the control preparation cannot be used anymore after being placed at room temperature for 1 month; while for the preparations provided by the present invention (taking the suspension concentrates prepared in Example 9 and Example 37 as examples), after being placed for 12 months, the surface tension changes little, and the average particle size (D90) changes little by 90%. This indicates that the samples of both examples can not only meet the wetting of the liquid medicine on the target, but also the ground particles basically do not change over time. The finer the particles, the better the drug effect, and vice versa, the worse the drug effect is exerted. The data in the above table confirm that the suspension concentrate prepared by using the auxiliary agent system of the present invention is convenient to apply and beneficial to the exertion of the drug effect.

[0183] The influence of adding the surface modification adjuvant on the surface tension is shown in Table 3: Sample 1 does not contain the surface modification adjuvant, Sample 2 adds the surface modification adjuvant according to the embodiment, and the control preparation dissolves the binary insecticidal and acaricidal composition technical in acetone (the content of acetone in the total solution does not exceed 10%), and then prepares a solution with the required concentration with 0.1% Tween 80 aqueous solution.

[0184] Table 3. Influence of Adding Surface Modification Adjuvant on Surface Tension

[0185]

[0186] Table 3. Influence of Adding Surface Modification Adjuvant on Surface Tension (Continued 1)

[0187]

[0188] Table 3. Influence of Adding Surface Modification Adjuvant on Surface Tension (Continued 2)

[0189]

[0190] Table 3. Influence of Adding Surface Modification Adjuvant on Surface Tension (Continued 3)

[0191]

[0192] Table 3. Influence of Adding Surface Modification Adjuvant on Surface Tension (Continued 4)

[0193]

[0194] It can be seen from the above table that the addition of the surface modification adjuvant reduces the surface tension of the dilution solution, which can improve the transfer efficiency of the active ingredient in the processes of atomization, deposition, attachment and spreading, penetration and absorption, and conduction from application to the target and its growth medium. It increases the retention amount of the pesticide active ingredient on the plant surface, prolongs the retention time and enhances the permeability, thereby improving the bioavailability and effective utilization efficiency of the pesticide.

[0195] The above embodiments are only to illustrate the technical concept and features of the present invention, and the purpose is to enable those who are familiar with this technology to understand the content of the present invention and implement it accordingly. It cannot be used to limit the protection scope of the present invention. Any equivalent changes or modifications made according to the essence of the present invention should be covered within the protection scope of the present invention. The content not described in detail in this specification belongs to the prior art well-known to those skilled in the art.

Claims

1. A binary insecticidal and acaricidal composition preparation, characterized in that: The preparation comprises an active ingredient, at least one auxiliary agent and a carrier; the active ingredient is active component A and active component B, active component A has the following structure, and active component B is selected from nereistoxin insecticides (B1), macrolide insecticides (B2), organophosphorus insecticides (B3), carbamate insecticides (B4), tetronic acid insecticides (B5), biogenic insecticides (B6), pyrethroid insecticides (B7), insect growth regulator insecticides (B8), amide insecticides (B9), nicotinic insecticides (B 10 ), insect feeding deterrent insecticides (B 11 ), fungicides (B 12 ), acaricides (B 13 ), or one or several of other insecticides and inorganic substances (B 14 ); the weight ratio of active component A to active component B is 100:1 to 1:100; The active ingredient A has the following structure:

2. The binary insecticidal and acaricidal composition preparation according to claim 1, characterized in that: The formulation is one or more of a suspension concentrate, a suspoemulsion, a microcapsule granule, a microcapsule suspension, a dispersible oil suspension, an emulsion in water, a soluble concentrate, a dispersible concentrate, a tablet, a dispersible oil, an ultra-low volume agent, a powder, a wettable powder, a granule, a microemulsion, an emulsifiable concentrate, a water dispersible granule, an emulsifiable powder, an emulsifiable granule, a floating granule, an effervescent granule, an effervescent tablet, a sustained release granule or an aerosol, a seed treatment dry powder, a seed treatment dispersible powder, a seed treatment liquid, a seed treatment emulsion, a seed treatment suspension concentrate.

3. The binary insecticidal and acaricidal composition preparation according to claim 1 or 2, characterized in that: The adjuvant is one or more of a surface modification adjuvant, an emulsifier, a dispersant, a wetting agent, a binder, a stabilizer, an antifoaming agent, an antifreezing agent, a preservative, a penetrant, a thickener.

4. The binary insecticidal and acaricidal composition preparation according to claim 3, characterized in that: The adjuvant is a surface modification adjuvant and one or more of an emulsifier, a dispersant, a wetting agent, a binder, a stabilizer, an antifoaming agent, an antifreezing agent, a preservative, a penetrant, a thickener.

5. The binary insecticidal and acaricidal composition preparation according to claim 4, characterized in that: The surface modification adjuvant is selected from one or more of a fluorinated polyacrylate, a sulfosuccinate, a modified alkoxide, a silicone surfactant, an alkoxylated surfactant, a star polymer.

6. Use in the binary insecticidal and acaricidal composition preparation according to claim 1, characterized in that: Application of the formulation in the control of pests, mite pests or sanitary pests on ornamental plants, fruit trees, vegetables, cotton, flowers, tea and cereal crops.

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