Composition for dispelling effects of alcohol and protecting liver, beverage, preparation method and application

Abstract

The composition for dispelling the effects of alcohol and protecting the liver is prepared from the following raw materials in parts by weight: 2 parts of rhizoma curcumae longae, 4 parts of radix puerariae, 2 parts of semen myristicae, 1 part of herba dendrodii officinalis, 2 parts of camphorwood, 1 part of zaocys dhumnade and 4 parts of liquorice root.

Description

Technical Field

[0001] The present invention relates to the field of functional foods, and particularly to an anti-hangover and liver-protecting composition, a beverage, a preparation method and an application thereof. Background Art

[0002] Wine is the first functional beverage for humans regardless of region, and the consumption of alcoholic beverages has even started before the beginning of human civilization. The wine culture in China has a long history and is also a very solemn and elegant food. It can be seen in occasions such as sacrifices, alliances, victory celebrations, weddings, funerals, and happy gatherings and send-offs, where wine is used to celebrate and add to the fun or for sacrificial ceremonies.

[0003] However, long-term excessive drinking can have various negative impacts on the liver. Initially, it usually manifests as fatty liver, and then it can develop into alcoholic hepatitis, liver fibrosis, and cirrhosis, and even progress to liver cancer. In severe cases, it can be complicated by liver failure and upper gastrointestinal bleeding, etc.

[0004] However, due to cultural traditions, it is impossible for people to significantly reduce the use of alcohol. Thus, how to minimize the harm of alcoholic beverages to the body, especially to the liver, has always been a necessity. Traditional Chinese medicine believes that wine is a product of dampness and heat, and its qi ascends. Subjects with a hangover have water retention in their bodies, and due to wine, the retained drink surges upward. After drinking, they often experience discomfort symptoms such as nausea, thirst, headache, dizziness, and loss of appetite, which can cause harm to important organs of the human body such as the liver, kidney, stomach, spleen, and heart. Summary of the Invention

[0005] One of the purposes of the present invention is to provide an anti-hangover and liver-protecting composition, a beverage, a preparation method and an application thereof, which can relieve hangover and protect the liver.

[0006] One of the purposes of the present invention is to provide an application of an anti-hangover and liver-protecting composition, a beverage, and a preparation method, which can protect the central nervous system and reduce the occurrence of adverse behaviors after drinking.

[0007] In order to achieve at least one of the invention purposes of the present invention, the present invention provides an anti-hangover and liver-protecting composition, which is made of raw materials in the following weight ratios: 2 parts of turmeric, 4 parts of kudzu root, 2 parts of nutmeg, 1 part of dendrobium officinale, 2 parts of camphorwood, 1 part of zaocys dhumnades, and 4 parts of licorice.

[0008] In some embodiments, pharmaceutically acceptable excipients or carriers are added, and the anti-hangover and liver-protecting composition is made into granules, capsules, tablets or oral liquids.

[0009] In some embodiments, the preparation method of the anti-hangover and liver-protecting composition includes the following steps:

[0010] Weigh 20 grams of turmeric, 40 grams of kudzu root, 20 grams of nutmeg, 10 grams of dendrobium officinale, 20 grams of camphorwood, 10 grams of zaocys dhumnades, and 40 grams of licorice in proportion and mix them;

[0011] Grind the total 160 grams of medicinal materials into powder;

[0012] Pour all the medicinal powder into a container and add one liter of distilled water;

[0013] Conduct decocting;

[0014] Decoct over low heat for half an hour; and

[0015] After cooling, filter to obtain the composition for relieving hangover and protecting the liver.

[0016] In some embodiments, the preparation method of the composition for relieving hangover and protecting the liver includes the following steps: calculated by 1000 grams per portion, weigh 2 portions of turmeric, 4 portions of kudzu root, 2 portions of nutmeg, 1 portion of dendrobium officinale, 2 portions of camphorwood, 1 portion of zaocys dhumnades, and 4 portions of licorice and mix them; grind them into powder; add the above mixed powder into a container, then add 50 liters of distilled water, stir and soak at room temperature for 2 hours; then add 50 liters of distilled water and heat for decocting; control the heating intensity so that the heating evaporation amount is about 25 liters per hour, and stir once every 30 minutes in the middle; stop heating after two hours and place at room temperature; after cooling, take the supernatant and concentrate and filter to obtain the composition for relieving hangover and protecting the liver.

[0017] According to another aspect of the present invention, the present invention also provides a royal jelly drink for relieving hangover and protecting the liver, which includes the composition for relieving hangover and protecting the liver as described above and royal jelly.

[0018] According to another aspect of the present invention, the present invention also provides a food or medicine for relieving hangover and protecting the liver, and the food or medicine for relieving hangover and protecting the liver includes the composition for relieving hangover and protecting the liver as described above.

[0019] According to another aspect of the present invention, the present invention also provides a composition drink for relieving hangover and protecting the liver, and the composition drink for relieving hangover and protecting the liver includes the composition for relieving hangover and protecting the liver and a glucose solution, and the composition for relieving hangover and protecting the liver is made from raw materials with the following weight ratios: 2 portions of turmeric, 4 portions of kudzu root, 2 portions of nutmeg, 1 portion of dendrobium officinale, 2 portions of camphorwood, 1 portion of zaocys dhumnades, and 4 portions of licorice.

[0020] According to another aspect of the present invention, the present invention also provides a bursting bead, which is prepared by using the composition for relieving hangover and protecting the liver as described above.

[0021] According to another aspect of the present invention, the present invention also provides an application of the composition for relieving hangover and protecting the liver as described above in the field of drinks.

[0022] According to another aspect of the present invention, the present invention also provides an application of the composition for relieving hangover and protecting the liver in the preparation of a product with the function of protecting the liver and relieving hangover.

[0023] The beneficial effects of the present invention include but are not limited to:

[0024] Curcumin contained in turmeric belongs to a class of polyphenolic compounds. This substance is the main component for turmeric to release its own pharmacological activities. Pharmacological experiments have clearly shown that curcumin can effectively anti-tumor, antioxidant and anti-inflammatory, etc., and has low toxicity and high safety. In the present invention, its anti-tumor and antioxidant effects are mainly utilized.

[0025] Kudzu root is not only rich in nutrients, but also contains more than a dozen flavonoid compounds such as puerarin, daidzin, daidzein, and puerarin xyloside. It can reduce the concentration of ethanol in the blood, protect the liver, and can also protect the central nervous system, reducing the occurrence of adverse behaviors after drinking.

[0026] As recorded in "Compendium of Materia Medica", nutmeg warms the middle-jiao, promotes digestion and stops diarrhea, treats abdominal pain due to accumulation of cold, cholera, sudden syncope, cold pathogen stagnation, vomiting with frothy cold qi, and infantile milk retention. It regulates qi in the middle-jiao, promotes appetite, relieves alcohol toxicity, and disperses qi in the external collaterals of the skin. In the present invention, its effect of relieving alcohol toxicity is mainly utilized.

[0027] Also in "Compendium of Materia Medica", Li Shizhen evaluated Dendrobium officinale as: "Strengthening yin and tonifying essence, taking it for a long time can thicken the intestines and stomach, supplement internal deficiency, balance the stomach qi, and promote muscle growth". In the present invention, its effect on the digestive system is mainly utilized.

[0028] Soaking snakes in wine has a long history. "Compendium of Materia Medica" says: "Or make wine and drink... as the snake wine of Zaocys dhumnades". Zaocys dhumnades is an important one among the detoxifying drugs in traditional Chinese medicine. In the present invention, its detoxifying effect is mainly utilized.

[0029] For camphorwood and licorice, in the present invention, their effect of coordinating various medicinal herbs is mainly utilized.

[0030] The combination of each component of the present invention can be used before drinking, which helps to relieve hangover and protect the liver. BRIEF DESCRIPTION OF THE DRAWINGS

[0031] Figure 1 It is a graph of the alcohol toxicity tolerance experiment of a hangover and liver protection composition drink for mice according to an embodiment of the present invention.

[0032] Figure 2 It is a graph of the alcohol toxicity tolerance experiment of a hangover and liver protection composition drink for mice according to an embodiment of the present invention.

[0033] Figure 3 It is a comparison graph of the relief of post-drinking symptoms of a hangover and liver protection composition drink for mice according to an embodiment of the present invention.

[0034] Figure 4 It is a comparison chart of the liver protection effect of an anti-hangover and liver protection composition drink according to an embodiment of the present invention. Detailed implementation mode

[0035] The following description is used to disclose the present invention so that those skilled in the art can implement the present invention. The preferred embodiments in the following description are only examples, and other obvious variations can be thought of by those skilled in the art. The basic principles defined in the following description of the present invention can be applied to other implementation schemes, variant schemes, improvement schemes, equivalent schemes, and other technical schemes that do not deviate from the spirit and scope of the present invention.

[0036] The parts mentioned in the embodiments are all weight ratios.

[0037] In a preferred embodiment, an anti-hangover and liver protection composition is made from the following raw materials in the following weight ratios: 2 parts of turmeric, 4 parts of kudzu root, 2 parts of nutmeg, 1 part of dendrobium officinale, 2 parts of camphorwood, 1 part of zaocys dhumnades, and 4 parts of licorice.

[0038] Preferably, pharmaceutically acceptable excipients or carriers are added, and the anti-hangover and liver protection composition is made into granules, capsules, tablets or oral liquids.

[0039] Example of preparation method 1:

[0040] The preparation method of the anti-hangover and liver protection composition includes the following steps:

[0041] Take the above-mentioned raw materials in the above weight parts (for example, the ratio unit: gram), and the specific operations are as follows:

[0042] S10: Calculated at 10 grams per part, weigh 20 grams of turmeric, 40 grams of kudzu root, 20 grams of nutmeg, 10 grams of dendrobium officinale, 20 grams of camphorwood, 10 grams of zaocys dhumnades, and 40 grams of licorice according to the ratio and mix them;

[0043] S20: Grind the total 160 grams of medicinal materials into powder; preferably, use a small stone mill or a powder mill with a stainless steel blade;

[0044] S30: Pour all the medicinal powder into a container and add about one liter of distilled water;

[0045] S40: Boil; preferably, first heat with medium heat until boiling. Among them, when using a gas stove, the medium heat is that the top of the flame just touches the bottom of the container pot; simmer for half an hour; preferably, when using a gas stove, the medium heat is: on the gas stove, the height of the flame is about half of the distance from the gas outlet to the bottom of the container pot;

[0046] S60: After cooling, filter to obtain the anti-hangover and liver protection composition. Preferably, filter with a filter bag or a filter screen. Preferably, the specification is 200 mesh.

[0047] Preparation Method Example 2:

[0048] The preparation method of the composition for relieving hangover and protecting the liver comprises the following steps:

[0049] S100: Wash and dry the raw materials: Weigh 2 parts of turmeric, 4 parts of kudzu root, 2 parts of nutmeg, 1 part of Dendrobium officinale, 2 parts of camphorwood, 1 part of Zaocys dhumnades, and 4 parts of licorice and mix them according to 1000 grams per portion;

[0050] S200: Grind: Grind a total of 16 kg of medicinal materials into powder; preferably, use an electric grinder with a stainless steel blade;

[0051] S300: Soak the materials; preferably, add the above mixed powder into a container (such as a container with a specification of 120 liters or more), then add 50 liters of distilled water, stir and soak at room temperature for 2 hours;

[0052] S400: Add another 50 liters of distilled water and heat to boil; preferably, first heat to boiling, control the heating intensity so that the heating time to boiling is controlled between 30 minutes and 60 minutes;

[0053] S500: Reduce the heating intensity after boiling; preferably, control the heating intensity so that the evaporation rate is about 25 liters per hour, and stir once every 30 minutes in the middle;

[0054] S600: Stop heating after two hours and let it stand overnight at room temperature;

[0055] S700: Take the supernatant for concentration and filtration to obtain the composition for relieving hangover and protecting the liver; preferably, first filter it roughly with a 120-mesh filter screen, and then filter it precisely with a filter with a pore size of 5 microns in a clean workshop;

[0056] S800: Package it into boxes of 200 ml in a clean workshop;

[0057] S900: Store the packaged drinks refrigerated at 4°C.

[0058] Effect Example:

[0059] Establish a cell model for detecting alcohol metabolism:

[0060] A: Select multiple cell lines (>10 kinds) and culture them in a culture dish until they reach the best state.

[0061] B: Add alcohol at different concentrations.

[0062] C: Culture for 24 hours or 48 hours.

[0063] D: Detect the change in alcohol concentration.

[0064] The final results show that the cell line HepG2 (an immortalized cell line derived from hepatocytes) has the function of reducing alcohol concentration and can be used as a model for alcohol detection.

[0065] Furthermore, the mouse alcohol toxicity tolerance experiment is as follows.

[0066] Experimental materials: 80 C57BL / 6 strain mice, with an equal number of males and females. The anti-alcohol and liver-protecting composition beverage used in the experiment was prepared according to the method of the present invention.

[0067] Experimental method: Control group (40 mice, with an equal number of males and females): Males and females were randomly divided into 4 groups according to body weight. The following 4 dose groups were designed for the alcohol dose: 12.5 g / kg, 11 g / kg, 9.5 g / kg, 8 g / kg. After the mice were fasted for 12 hours, during the fasting period, the experimental mice could drink water freely. After the fasting period ended, each group was intragastrically administered ethanol at the above doses. Observe the poisoning and death conditions of the mice within 24 hours.

[0068] The experimental group design is basically the same as that of the control group. The only difference is that during the fasting period, the experimental mice could not drink water and could only drink the anti-alcohol and liver-protecting composition beverage of the present invention. The results are as Figure 1 shown.

[0069] According to the Bliss method, the calculated LD50 of ethanol in the experiment was 10.34 g / kg, LD90 was 11.98 g / kg, and the 95% confidence interval was 9.43 - 10.91 g / kg.

[0070] Experimental results:

[0071] According to the Bliss method, the calculated median lethal dose of ethanol in the experiment was: in the control group, LD50 = 10.34 g / kg body weight, and the 95% confidence interval was 9.43 - 10.91 g / kg body weight. In the experimental group, LD50 = 10.95 g / kg body weight, and the 95% confidence interval was 9.88 - 11.50 g / kg body weight. Performing a multi-sample two-sided Z test, the obtained sample significance level p value was 0.0136, which was significantly less than the commonly used standard of 0.05. Therefore, the anti-alcohol and liver-protecting composition beverage of the present invention significantly improved the tolerance of mice to ethanol.

[0072] Furthermore, the effect of the anti-alcohol and liver-protecting composition beverage on the central inhibitory effect of ethanol (i.e., the mouse alcohol detoxification ability experiment) is as follows.

[0073] Experimental materials: 40 C57BL / 6 strain mice, with an equal number of males and females. The anti-alcohol and liver-protecting composition beverage was prepared according to the method of the present invention.

[0074] Experimental method: Control group (20 mice, 10 males and 10 females): Males and females were randomly divided into 4 groups according to body weight. The following 4 dose groups were designed for the alcohol dose: 0.75 g / kg, 0.5 g / kg, 0.25 g / kg, 0 g / kg. After the mice were fasted for 12 hours, during the fasting period, the experimental mice could drink water freely. After the fasting period ended, each group was intragastrically administered ethanol at the above doses. Observe the time when the righting reflex of the mice disappeared and the recovery time: Use the disappearance of the righting reflex of the mice as the sleep index, record the time when the righting reflex disappeared and the recovery time, and calculate the tolerance time (the time from the administration of ethanol to the disappearance of the righting reflex) and the maintenance time (the time from the disappearance of the righting reflex to the recovery).

[0075] The experimental group was designed basically the same as the control group. The only difference was that during the fasting period, the experimental mice could not drink water and could only drink the drink containing the anti-alcoholic and liver-protecting composition. The results are as Figure 2 .

[0076] Experimental results:

[0077] As Figure 2 shown, the sleep tolerance time of the mice in each dose group of the preventive administration of the drink containing the anti-alcoholic and liver-protecting composition was prolonged compared with that of the control group at the same dose. However, the sleep maintenance time decreased. It shows that the drink containing the anti-alcoholic and liver-protecting composition has an obvious preventive effect on the reaction of the mice administered with ethanol. And it is significantly correlated with the dose. There is a significant statistical difference between the two (p-value is less than 0.05%).

[0078] In the clinical example, for example, there were 46 subjects with mild alcoholic liver injury. Their conditions were all found through clinical examinations that the activity of alanine aminotransferase (ALT) increased, from the normal value of 0 - 40 IU / L to 40 - 80 IU / L. They were diagnosed with mild alcoholic liver injury and all had a history of regular drinking. They drank alcohol two to three times a week, and the amount of alcohol per time (calculated as pure alcohol) was 50 - 200 ml. Regardless of the amount of alcohol, the subjects all reported discomfort after drinking. Including central nervous system excitement, dizziness, nausea, flushing, whole body redness, rapid heartbeat, etc. However, the situations of severe alcohol poisoning including lethargy, coma, respiratory depression, blood pressure drop, cyanosis, incontinence of urine and feces were excluded. On the basis of the informed consent of these subjects, they were randomly divided into an experimental group and a control group according to the random principle, with 23 subjects in each group. Experimental group: 15 male subjects and 8 female subjects, their ages were 31 - 59 years old, and the average age was (46.3 ± 9.2) years old. Control group: 15 male subjects and 8 female subjects, their ages were 32 - 58 years old, and the average age was (45.2 ± 10.1) years old. There was no significant statistical difference in the gender, age, drinking type, drinking amount, past history, etc. between the two groups of subjects (P > 0.05), and the data were comparable.

[0079] Treatment method: To reduce the deviation caused by separate decoction, a unified rationing method is adopted. 100 liters of the drink are prepared at one time through the preparation method of Example 2 and stored in a 4-degree cold storage for regular distribution.

[0080] Experimental group: Subjects were given the drink containing the hangover and liver-protecting composition of the present invention, 200 ml / d.

[0081] Control group: Subjects were given chrysanthemum tea drink, 200 ml / d.

[0082] The use of the drink is divided into three stages, each stage lasting 7 days, with a 3-day interval in between. The total time of using the drink of the present invention is 21 days. At the end of the three stages, the total time is 30 days. During this period, the subjects' work and life are normal as usual.

[0083] The criteria for evaluating the curative effect are as follows:

[0084] Marked effect:

[0085] Hangover: After using this product, symptoms such as nausea, vomiting, dizziness, headache, and flushing in the subjects disappear or are significantly alleviated.

[0086] Liver protection: After using this product, the ALT transaminase of the subjects decreases by more than 10 IU / L.

[0087] Effective:

[0088] Hangover: After using this product, symptoms such as nausea, vomiting, dizziness, headache, and flushing in the subjects are partially alleviated.

[0089] Liver protection: After using this product, the ALT transaminase of the subjects decreases by more than 5 IU / L.

[0090] Invalid:

[0091] Hangover: After using this product, symptoms such as nausea, vomiting, dizziness, headache, and flushing in the subjects are not alleviated.

[0092] Liver protection: After using this product, the ALT transaminase of the subjects does not decrease.

[0093] Furthermore, a statistical method is adopted:

[0094] The data in this study are processed using SPSS 17.0 software. The t-test is used, and the chi-square test is used for count data. P < 0.05 indicates that the difference is statistically significant.

[0095] The results are as follows:

[0096] Hangover: The total effective rate is defined as the sum of marked effect and effective.

[0097] The total effective rate of treatment for the subjects in the experimental group was 91.3%, and the total effective rate of treatment for the subjects in the control group was 21.7%. The total effective rate of treatment for the subjects in the experimental group was higher than that of the control group, with a significant difference and statistical significance (P < 0.05).

[0098] Liver protection: The total effective rate is defined as the sum of marked effect and effective effect.

[0099] The total effective rate of treatment for the subjects in the experimental group was 91.3%, and the total effective rate of treatment for the subjects in the control group was 21.7%. The total effective rate of treatment for the subjects in the experimental group was higher than that of the control group, with a significant difference and statistical significance (P < 0.05).

[0100] Further, the comparison of clinical efficacy - hangover is as Figure 3 shown.

[0101] Among them, the total marked effective rate = number of marked effective cases / total number of cases * 100%; total effective rate = (number of marked effective cases + number of effective cases) / total number of cases * 100%; ineffective rate = number of ineffective cases / total number of cases * 100%.

[0102] Experimental group:

[0103] Total marked effective rate = (7 + 5) / 23 * 100% = 52.17%;

[0104] Total effective rate = (12 + 9) / 23 * 100% = 91.3%;

[0105] Ineffective rate = (1 + 1) / 23 = 8.7%.

[0106] Control group:

[0107] Total marked effective rate = (1 + 0) / 23 * 100% = 4.3%;

[0108] Total effective rate = (1 + 4) / 23 * 100% = 21.7%;

[0109] Ineffective rate = (12 + 6) / 23 = 78.3%.

[0110] Further, the comparison of clinical efficacy - liver protection is as Figure 4 shown.

[0111] Experimental group:

[0112] Total marked effective rate = (7 + 3) / 23 * 100% = 43.4%;

[0113] Total effective rate = (13 + 6) / 23 * 100% = 82.6%;

[0114] Ineffective rate = (2 + 2) / 23 = 17.4%.

[0115] Control group:

[0116] Total marked effective rate = (2 + 0) / 23 * 100% = 8.6%;

[0117] Total effective rate = (2 + 4) / 23 * 100% = 26.1%;

[0118] Ineffective rate = (9 + 6) / 23 = 65.2%.

[0119] The results showed that the total effective rate of the experimental group for hangover treatment was 91.3%, and that of the control group was 21.7%. Therefore, the drink of the hangover and liver - protecting composition of the present invention has a significant improvement in the hangover ability. The difference is significant and statistically significant (P < 0.05).

[0120] The total effective rate of the experimental group for hangover treatment was 82.6%, and that of the control group was 26.1%. The difference was also very significant and statistically significant (P < 0.05). Compared with the hangover ability, the value decreased slightly but was also very significant.

[0121] Examples of typical subjects are as follows:

[0122] Example 1: Li Mou, male, 52 years old. Under normal circumstances, when drinking 500m1 * 3 bottles of Tsingtao Beer, he would have strong after - drinking symptoms, including turning red all over, slow reaction, drowsiness, and sometimes severe vomiting. One hour before drinking, he took 200m1 of the drink of the hangover and liver - protecting composition prepared in Example 1 of the preparation method of the present invention. For all the above symptoms, only the symptom of blushing remained.

[0123] Example 2: Chang Mou, male, 33 years old. Due to work needs, he must drink three or four times a week. Because of his poor capacity for liquor, he suffered a lot every time. Generally, he drank 5 taels of white liquor (40 - 60 degrees) each time, and as a result, he vomited every time, had severe headaches, and his ALT transaminase reached 75.7 IU / L for half a year. The doctor advised him to quit drinking but he couldn't do it. After taking the drink of the hangover and liver - protecting composition of the present invention for one month (a total of 21 doses), when the drinking amount was normal, the vomiting completely disappeared, and the headache was effectively improved. Moreover, the transaminase dropped to about 23 IU / L, reaching the normal level.

[0124] Example 3: Li Mou, female, 58 years old. She considered herself to have a good capacity for liquor and had maintained the habit of drinking alcohol since adulthood for over 30 years. Generally, she drank twice a week, consuming about 4 to 6 bottles of liquor or about 6 liang of Chinese liquor each time. After drinking, her face used to just turn a bit red and she would talk more (i.e., central nervous system excitement). However, in the past three years, after drinking the same amount of alcohol, she had various reactions after drinking. The main sensations were unsteady walking, less talking instead of more talking (central nervous system inhibition), and sometimes vomiting. In the experimental group of the clinical trial of the drink containing the anti-hangover and liver-protecting composition of the present invention, the experimental result was that the reactions after drinking basically returned to the level of three years ago.

[0125] Those skilled in the art should understand that the embodiments of the present invention described above and shown in the drawings are only examples and do not limit the present invention. The object of the present invention has been completely and effectively achieved. The function and structural principle of the present invention have been demonstrated and explained in the embodiments. Without departing from this principle, any deformation or modification can be made to the embodiments of the present invention.

Claims

1. A composition for relieving hangover and protecting the liver, characterized in that, The composition for relieving hangover and protecting the liver is made from the following raw materials in the following weight ratios: 2 parts of turmeric, 4 parts of kudzu root, 2 parts of nutmeg, 1 part of dendrobium officinale, 2 parts of camphorwood, 1 part of zaocys dhumnades, and 4 parts of liquorice.

2. The composition for relieving hangover and protecting the liver according to claim 1, characterized in that, Adding pharmaceutically acceptable excipients or carriers, the composition for relieving hangover and protecting the liver is made into granules, capsules, tablets or oral liquids.

3. The composition for relieving hangover and protecting the liver according to claim 1, characterized in that, The preparation method of the composition for relieving hangover and protecting the liver comprises the following steps: Weighing 20 grams of turmeric, 40 grams of kudzu root, 20 grams of nutmeg, 10 grams of dendrobium officinale, 20 grams of camphorwood, 10 grams of zaocys dhumnades, and 40 grams of liquorice according to the ratio and mixing them; Grinding the total 160 grams of medicinal materials into powder; Pouring all the medicinal powder into a container and adding one liter of distilled water; Conducting decoction; Decocting with slow fire for half an hour; and Filtering after cooling to obtain the composition for relieving hangover and protecting the liver.

4. The composition for relieving hangover and protecting the liver according to claim 1, wherein The preparation method of the composition for relieving hangover and protecting the liver comprises the following steps: Calculated by 1000 grams per portion, weighing 2 parts of turmeric, 4 parts of kudzu root, 2 parts of nutmeg, 1 part of dendrobium officinale, 2 parts of camphorwood, 1 part of zaocys dhumnades, and 4 parts of liquorice and mixing them; grinding them into powder; adding the above mixed powder into a container, then adding 50 liters of distilled water, stirring and soaking at room temperature for 2 hours; adding another 50 liters of distilled water and heating for decoction; controlling the heating intensity so that the heating evaporation is about 25 liters per hour, and stirring once every 30 minutes in the middle; stopping heating after 2 hours and placing at room temperature; taking the supernatant after cooling, concentrating and filtering to obtain the composition for relieving hangover and protecting the liver.

5. A royal jelly drink for relieving hangover and protecting the liver, characterized in that, The royal jelly drink for relieving hangover and protecting the liver comprises the composition for relieving hangover and protecting the liver as described in any one of claims 1 to 4 and royal jelly.

6. A food or medicine for relieving hangover and protecting the liver, characterized in that: The food or drug for relieving hangover and protecting the liver comprises the composition for relieving hangover and protecting the liver as described in any one of claims 1 to 4.

7. A composition drink for relieving hangover and protecting the liver, characterized in that, The composition drink for relieving hangover and protecting the liver comprises the composition for relieving hangover and protecting the liver and a glucose solution. The composition for relieving hangover and protecting the liver is made from the following raw materials in the following weight ratios: 2 parts of turmeric, 4 parts of kudzu root, 2 parts of nutmeg, 1 part of dendrobium officinale, 2 parts of camphorwood, 1 part of zaocys dhumnades, and 4 parts of liquorice.

8. A popping bead, characterized in that, Prepared by using the composition for relieving hangover and protecting the liver as described in any one of claims 1 to 4.

9. Use of the composition for relieving hangover and protecting the liver as described in any one of claims 1 to 4 in the field of drinks.

10. Use of the composition for relieving hangover and protecting the liver as described in any one of claims 1 to 4 in the preparation of products with the function of protecting the liver and relieving hangover.

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