Fragrant UV (ultraviolet) photocuring contact lens material as well as preparation method and application thereof

Abstract

The invention belongs to the technical field of contact lenses, and particularly discloses a fragrant UV (ultraviolet) photocuring contact lens material as well as a preparation method and application thereof. The contact lens material disclosed by the invention is prepared from 30 to 40 parts of a siloxane monomer, 50 to 80 parts of a hydrophilic monomer, 0.01 to 0.1 part of a nanocapsule, 0.5 to 1.5 parts of a cross-linking agent, 0.2 to 0.8 part of an ultraviolet light absorber and 0.5 to 1.5 parts of an initiator. Wherein the core material of the nano capsule is prepared from alpha-bisabolol, vanillin and apigenin. By adding the active components, xerophthalmia, eye inflammation and eye dryness can be relieved, and many problems caused by wearing contact lenses are avoided to a certain extent; the invention further discloses application of the nanocapsule, slow release of effective components is achieved, and stimulation to eyes is avoided. In addition, the mask also has the effects of emitting fragrance for a long time and making a wearer have physical and mental pleasure.

Description

Technical Field

[0001] The present invention relates to the technical field of contact lenses, and particularly to a scented UV - curable contact lens material, its preparation method and application. Background Art

[0002] As an important tool for modern vision correction, contact lenses have undergone several technological innovations since their inception in the mid - 20th century. From the initial hard lenses to today's soft hydrogels and silicone hydrogel materials, contact lenses have made significant progress in terms of comfort, oxygen permeability, and wearing duration. Especially silicone hydrogel contact lenses, which have the characteristics of ultra - high oxygen permeability and high water content, can reduce dry eye discomfort and enable comfortable wearing for more than 12 hours. With their unique advantages, they have become the mainstream choice in the modern contact lens market.

[0003] However, with the growing demand of consumers for personalized and multifunctional products, traditional contact lenses can no longer fully meet market expectations. In recent years, innovative products such as smart contact lenses and drug - releasing contact lenses have emerged one after another, showing great potential in this field. Against this background, scented UV - curable contact lenses, as a new type of product integrating sensory experience and advanced material technology, have important research value and application prospects.

[0004] With the wide application of silicone hydrogel contact lenses and the significant extension of the comfortable wearing time (even products that can be worn continuously for 7 days have emerged), it has created the possibility for the development of the fragrance - slow - release function of contact lenses. How to perfectly combine fragrance molecules with the contact lens matrix, ensure the stability and safety of fragrance release without affecting the oxygen permeability and optical properties of the lens, and at the same time enrich the functions of contact lenses has become the primary problem to be solved.

[0005] Therefore, how to provide a scented UV - curable contact lens material, its preparation method and application, and incorporate fragrance - functional molecules into the contact lens material to achieve the function of slow - releasing fragrance while ensuring safety is an urgent problem to be solved in this field. Summary of the Invention

[0006] In view of this, the present invention provides a scented UV - curable contact lens material, its preparation method and application, which solve the problem that the existing contact lens materials have a single function and do not have the function of slow - releasing fragrance.

[0007] To achieve the above - mentioned purpose, the present invention adopts the following technical solutions:

[0008] A scented UV - curable contact lens material is prepared from the following raw materials in parts by mass:

[0009] 30 to 40 parts of siloxane monomers, 50 to 80 parts of hydrophilic monomers, 0.01 to 0.1 part of nano-capsules, 0.5 to 1.5 parts of cross-linking agents, 0.2 to 0.8 part of ultraviolet absorbers, 0.5 to 1.5 parts of initiators;

[0010] The nano-capsules include a wall material and a core material, and the core material of the nano-capsules includes α-bisabolol, vanillin, and apigenin.

[0011] Preferably, the preparation method of the nano-capsules includes the following steps:

[0012] 1) Dissolve β-cyclodextrin in water to obtain an aqueous β-cyclodextrin solution;

[0013] Dissolve α-bisabolol, vanillin, and apigenin in ethanol to obtain a mixed solution;

[0014] 2) Drop the mixed solution into the aqueous β-cyclodextrin solution, and obtain an inclusion complex solution through an inclusion reaction; 3) Subject the inclusion complex solution to high-pressure homogenization, and then perform spray drying to obtain nano-capsules. Preferably, the mass concentration of β-cyclodextrin in the aqueous β-cyclodextrin solution is 60 to 80 g / L;

[0015] The total molar amount of α-bisabolol, vanillin, and apigenin and the molar ratio of β-cyclodextrin is 0.7 to 1:1;

[0016] The molar ratio of α-bisabolol, vanillin, and apigenin is 1 to 5:0.3 to 0.5:2 to 5;

[0017] The volume ratio of the mixed solution to the aqueous β-cyclodextrin solution is 1 to 5:10.

[0018] Preferably, the time of the inclusion reaction in step 2) is 1 to 2 h, and the temperature of the inclusion reaction is 50 to 60 °C.

[0019] Preferably, the pressure of the high-pressure homogenization is 20 to 50 MPa, the temperature of the high-pressure homogenization is 25 to 40 °C, and the number of times of high-pressure homogenization is 2 to 3 times;

[0020] The temperature of the spray drying is <80 °C;

[0021] The particle size of the nano-capsules is 20 to 250 nm.

[0022] Preferably, the siloxane monomers include one or more of methacryloxypropyl tris(trimethylsiloxy)silane, terminal divinyl polydimethylsiloxane, 1,3-bis(3-methacryloxypropyl)tetrakis(trimethylsiloxy)disiloxane, and N-(3-methacryloxy-2-hydroxypropyl)-3-aminopropyltriethoxysilane.

[0023] Preferably, the hydrophilic monomer includes one or more of N-vinylpyrrolidone, 2-hydroxyethyl methacrylate, butyl methacrylate, methacrylic acid, dimethylaminoethyl methacrylate, and glycerol methacrylate.

[0024] Preferably, the crosslinking agent includes one or more of ethylene glycol dimethacrylate, tetraethylene glycol dimethacrylate, and trimethylolpropane trimethacrylate;

[0025] The ultraviolet absorber includes benzotriazole ultraviolet absorbers and / or triazine ultraviolet absorbers;

[0026] The initiator includes one or more of bis(2,4,6-trimethylbenzoyl)phenylphosphine oxide, 2,4,6-trimethylbenzoyl-diphenylphosphine oxide, and 2-hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone.

[0027] Another object of the present invention is to provide a method for preparing a scented UV-curable contact lens material, comprising the following steps: mixing a siloxane monomer, a hydrophilic monomer, a nanocapsule, a crosslinking agent, an ultraviolet absorber, and an initiator, and then successively performing mold injection, UV curing, soaking, and sterilization to obtain a scented UV-curable contact lens material.

[0028] Another object of the present invention is to provide an application of the scented UV-curable contact lens material prepared by the above preparation method in the preparation of contact lenses.

[0029] It can be seen from the above technical solutions that, compared with the prior art, the present invention has the following beneficial effects:

[0030] 1. The contact lens material prepared by the present invention is a silicone hydrogel contact lens material, which has good wearing comfort and can meet long-term wearing. The present invention also adds a nanocapsule to the silicone hydrogel contact lens material. The nanocapsule is coated with α-bisabolol, vanillin, and apigenin. Among them, α-bisabolol is the main active ingredient of chamomile and has a mild woody-floral aroma. The addition of α-bisabolol also has the effect of alleviating eye inflammation or eye dryness caused by long-term wearing; vanillin can release aroma and has a relieving effect on dry eye; apigenin is a natural flavonoid compound, and the phenolic hydroxyl groups and double bonds in its molecular structure endow it with antioxidant and anti-inflammatory properties. Its combined action with α-bisabolol can also enhance its activity.

[0031] 2. The present invention adds α-bisabolol, vanillin, and apigenin in the form of nanocapsule coating, realizing the slow release of effective components and avoiding irritation to the eyes. Toxicology-related tests show that the silicone hydrogel contact lens material prepared by the present invention is non-irritating and has good biocompatibility.

[0032] 3. The silicone hydrogel contact lens material prepared by the present invention can emit fragrance for a long time, which makes the wearer feel happy physically and mentally, and can also relieve the discomfort caused by wearing contact lenses for a long time. DETAILED DESCRIPTION

[0033] The present invention provides a scented UV light-curing contact lens material, which is prepared from the following raw materials in parts by weight:

[0034] 30-40 parts of siloxane monomer, 50-80 parts of hydrophilic monomer, 0.01-0.1 parts of nanocapsules, 0.5-1.5 parts of crosslinking agent, 0.2-0.8 parts of ultraviolet absorber, 0.5-1.5 parts of initiator; under the above mass ratio, the addition amount of siloxane monomer can be 3234353638; the addition amount of hydrophilic monomer can be 52 parts, 55 parts, 58 parts, 60 parts, 62 parts, 65 parts, 68 parts, 70 parts, 72 parts, 75 parts, 78 parts parts; the addition amount of nanocapsules can be specifically 0.01 parts, 0.02 parts, 0.04 parts, 0.05 parts, 0.06 parts, 0.08 parts, and 0.09 parts; the addition amount of cross-linking agent can be specifically 0.6 parts, 0.8 parts, 1 parts, 1.2 parts, and 1.4 parts; the addition amount of ultraviolet absorber can be specifically 0.3 parts, 0.4 parts, 0.5 parts, 0.6 parts, and 0.7 parts; the addition amount of initiator can be specifically 0.6 parts, 0.8 parts, 1 parts, 1.2 parts, and 1.4 parts.

[0035] In the present invention, the nanocapsule comprises a wall material and a core material, and the core material of the nanocapsule comprises α-bisabolol, vanillin and apigenin.

[0036] In the present invention, the preparation method of the nanocapsule comprises the following steps:

[0037] 1) dissolving β-cyclodextrin in water to obtain a β-cyclodextrin aqueous solution;

[0038] Dissolving α-bisabolol, vanillin and apigenin in ethanol to obtain a mixed solution;

[0039] 2) adding the mixed solution dropwise into a β-cyclodextrin aqueous solution to obtain an inclusion complex solution through inclusion reaction; 3) homogenizing the inclusion complex solution under high pressure and then spray drying the solution to obtain nanocapsules.

[0040] In the present invention, the β-cyclodextrin is a biodegradable material, and using it as the wall material of the nanocapsule can achieve the sustained release of the effective components.

[0041] In the present invention, the mass concentration of β-cyclodextrin in the β-cyclodextrin aqueous solution is 60-80 g / L, specifically it can be 62 g / L, 64 g / L, 65 g / L, 66 g / L, 68 g / L, 70 g / L, 72 g / L, 74 g / L, 75 g / L, 76 g / L, 78 g / L.

[0042] In the present invention, the molar ratio of the total of α-bisabolol, vanillin and apigenin to β-cyclodextrin is 0.7-1:1, preferably 0.8-0.9:1, and more preferably 0.85:1.

[0043] In the present invention, the molar ratio of α-bisabolol, vanillin and apigenin is 1-5:0.3-0.5:2-5, preferably 2-4:0.35-0.45:3-4, and more preferably 3:0.4:3.5.

[0044] In the present invention, the volume ratio of the mixed solution to the β-cyclodextrin aqueous solution is 1-5:10, preferably 2-4:10, and more preferably 3:10.

[0045] In the present invention, the time of the inclusion reaction in step 2) is 1-2 h, specifically it can be 1.2 h, 1.4 h, 1.5 h, 1.6 h, 1.8 h; the temperature of the inclusion reaction is 50-60 °C, specifically it can be 52 °C, 54 °C, 55 °C, 56 °C, 58 °C.

[0046] In the present invention, the pressure of the high-pressure homogenization is 20-50 MPa, specifically it can be 25 MPa, 30 MPa, 35 MPa, 40 MPa, 45 MPa; the temperature of the high-pressure homogenization is 25-40 °C, specifically it can be 26 °C, 28 °C, 30 °C, 32 °C, 34 °C, 35 °C, 36 °C, 38 °C; the number of times of the high-pressure homogenization is 2-3 times;

[0047] In the present invention, the temperature of the spray drying <80 °C; specifically it can be 50 °C, 55 °C, 60 °C, 65 °C, 70 °C, 75 °C.

[0048] In the present invention, the particle size of the nanocapsules is 20-250 nm, specifically it can be 40 nm, 50 nm, 60 nm, 80 nm, 100 nm, 120 nm, 150 nm, 160 nm, 180 nm, 200 nm, 220 nm, 240 nm.

[0049] In the UV-curable contact lens material of the present invention, the nanocapsules have a small particle size, and the coating material is colorless and transparent, which will not affect the optical properties of the contact lenses.

[0050] In the present invention, the siloxane monomer includes one or more of methacryloxypropyl tris(trimethylsiloxy)silane, terminal divinyl polydimethylsiloxane, 1,3-bis(3-methacryloxypropyl)tetrakis(trimethylsiloxy)disiloxane, and N-(3-methacryloxy-2-hydroxypropyl)-3-aminopropyltriethoxysilane.

[0051] In the present invention, the hydrophilic monomer includes one or more of N-vinylpyrrolidone, 2-hydroxyethyl methacrylate, butyl methacrylate, methacrylic acid, dimethylaminoethyl methacrylate, and glycerol methacrylate.

[0052] In the present invention, the crosslinking agent includes one or more of ethylene glycol dimethacrylate, tetraethylene glycol dimethacrylate, and trimethylolpropane trimethacrylate.

[0053] In the present invention, the ultraviolet absorber includes benzotriazole ultraviolet absorbers and / or triazine ultraviolet absorbers.

[0054] In the present invention, the initiator includes one or more of bis(2,4,6-trimethylbenzoyl)phenylphosphine oxide, 2,4,6-trimethylbenzoyl-diphenylphosphine oxide, and 2-hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone.

[0055] The present invention also provides a method for preparing a fragrant UV-curable contact lens material, comprising the following steps: mixing a siloxane monomer, a hydrophilic monomer, nanocapsules, a crosslinking agent, an ultraviolet absorber, and an initiator, and then successively performing mold injection, UV curing, soaking, and sterilization to obtain a fragrant UV-curable contact lens material.

[0056] The present invention also provides an application of the fragrant UV-curable contact lens material prepared by the above preparation method in the preparation of contact lenses.

[0057] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present invention.

[0058] Example 1

[0059] Dissolve β-cyclodextrin in water (60 °C) to obtain an aqueous β-cyclodextrin solution; dissolve α-bisabolol, vanillin, and apigenin with a molar ratio of 2:0.3:3 in ethanol to obtain a mixed alcohol solution. Then, dropwise add the mixed alcohol solution to the aqueous β-cyclodextrin solution (mixed alcohol solution: aqueous β-cyclodextrin solution = 2:10, the mass concentration of the aqueous β-cyclodextrin solution is 65 g / L, and the total molar ratio of α-bisabolol, vanillin, and apigenin to β-cyclodextrin is 0.8:1), adjust the temperature to 60 °C, and stir for 1.5 h to obtain an inclusion complex solution. Then, subject the inclusion complex solution to high-pressure homogenization first at 20 MPa and 30 °C, and then at 30 MPa and 30 °C. After high-pressure homogenization, spray drying is carried out at 70 °C to obtain nanocapsules coated with α-bisabolol, vanillin, and apigenin. The particle size of the nanocapsules is 50 - 150 nm, and the loading amount is 10.5%.

[0060] Mix 35 parts of terminal divinyl polydimethylsiloxane, 70 parts of N-vinylpyrrolidone, 0.05 part of nanocapsules, 0.8 part of ethylene glycol dimethacrylate, 0.3 part of 2-(2'-hydroxy-5-methacryloyloxyethylphenyl)-2H-benzotriazole, and 1 part of 2,4,6-trimethylbenzoyl-diphenylphosphine oxide to obtain a contact lens material mixture. Then, inject the contact lens material mixture into a mold and carry out ultraviolet light curing molding. After curing, soak and sterilize in sequence to obtain a fragrant UV-cured contact lens material.

[0061] Example 2

[0062] Dissolve β-cyclodextrin in water (60 °C) to obtain an aqueous β-cyclodextrin solution; dissolve α-bisabolol, vanillin, and apigenin with a molar ratio of 5:0.5:5 in ethanol to obtain a mixed alcohol solution. Then, dropwise add the mixed alcohol solution to the aqueous β-cyclodextrin solution (mixed alcohol solution: aqueous β-cyclodextrin solution = 3:10, the mass concentration of the aqueous β-cyclodextrin solution is 60 g / L, and the total molar ratio of α-bisabolol, vanillin, and apigenin to β-cyclodextrin is 0.8:1), adjust the temperature to 60 °C, and stir for 2 h to obtain an inclusion complex solution. Then, subject the inclusion complex solution to high-pressure homogenization three times at 30 MPa and 30 °C. After high-pressure homogenization, spray drying is carried out at 60 °C to obtain nanocapsules coated with α-bisabolol, vanillin, and apigenin. The particle size of the nanocapsules is 20 - 120 nm, and the loading amount is 9.8%.

[0063] Mix 30 parts of vinyl-terminated polydimethylsiloxane, 58 parts of N-vinylpyrrolidone, 0.01 part of nanocapsules, 0.6 part of tetraethylene glycol dimethacrylate, 0.3 part of 2-(2'-hydroxy-5-methacryloyloxyethylphenyl)-2H-benzotriazole, and 0.5 part of bis(2,4,6-trimethylbenzoyl)phenylphosphine oxide to obtain a contact lens material mixture. Then, inject the contact lens material mixture into a mold and perform ultraviolet curing molding. After curing, perform soaking and sterilization in sequence to obtain a fragrant UV-cured contact lens material.

[0064] Example 3

[0065] Dissolve β-cyclodextrin in water (50 °C) to obtain an aqueous β-cyclodextrin solution; dissolve α-bisabolol, vanillin, and apigenin with a molar ratio of 3:0.4:4 in ethanol to obtain a mixed alcohol solution. Then, slowly add dropwise the mixed alcohol solution to the aqueous β-cyclodextrin solution (mixed alcohol solution: aqueous β-cyclodextrin solution = 1:10, the mass concentration of the aqueous β-cyclodextrin solution is 70 g / L, and the total molar ratio of α-bisabolol, vanillin, and apigenin to β-cyclodextrin is 0.8:1). Adjust the temperature to 50 °C and stir for 2 h to obtain an inclusion complex solution. Then, subject the inclusion complex solution to high-pressure homogenization twice at 20 MPa and 30 °C, and then at 30 MPa and 30 °C. After the high-pressure homogenization is completed, perform spray drying at 70 °C to obtain nanocapsules coated with α-bisabolol, vanillin, and apigenin. The particle size of the nanocapsules is 20 - 100 nm, and the loading amount is 9.5%.

[0066] Mix 40 parts of methacryloxypropyltris(trimethylsiloxy)silane, 75 parts of 2-hydroxyethyl methacrylate, 0.08 part of nanocapsules, 1.2 parts of ethylene glycol dimethacrylate, 0.8 part of 2-(2'-hydroxy-5-methacryloyloxyethylphenyl)-2H-benzotriazole, and 1.5 parts of 2,4,6-trimethylbenzoyl-diphenylphosphine oxide to obtain a contact lens material mixture. Then, inject the contact lens material mixture into a mold and perform ultraviolet curing molding. After curing, perform soaking and sterilization in sequence to obtain a fragrant UV-cured contact lens material.

[0067] Example 4

[0068] Dissolve β-cyclodextrin in water (60 °C) to obtain an aqueous β-cyclodextrin solution; dissolve α-bisabolol, vanillin, and apigenin with a molar ratio of 1:0.3:2 in ethanol to obtain a mixed alcohol solution. Then, dropwise add the mixed alcohol solution to the aqueous β-cyclodextrin solution (mixed alcohol solution: aqueous β-cyclodextrin solution = 1:10, the mass concentration of the aqueous β-cyclodextrin solution is 80 g / L, and the total molar ratio of α-bisabolol, vanillin, and apigenin to β-cyclodextrin is 1:1), adjust the temperature to 60 °C, and stir for 1 h to obtain an inclusion complex solution. Then, subject the inclusion complex solution to high-pressure homogenization first at 25 MPa and 25 °C, and then at 40 MPa and 25 °C. After high-pressure homogenization, spray drying is carried out at 75 °C to obtain nano-capsules coated with α-bisabolol, vanillin, and apigenin. The particle size of the nano-capsules is 100 - 200 nm, and the loading capacity is 10.2%.

[0069] Mix 36 parts of terminal divinyl polydimethylsiloxane, 70 parts of N-vinylpyrrolidone, 0.03 parts of nano-capsules, 0.6 parts of ethylene glycol dimethacrylate, 0.5 parts of 2-(2'-hydroxy-5-methacryloyloxyethylphenyl)-2H-benzotriazole, and 1.2 parts of 2,4,6-trimethylbenzoyl-diphenylphosphine oxide to obtain a mixed solution of contact lens material. Then, inject the mixed solution of contact lens material into a mold and carry out ultraviolet light curing molding. After curing, soak and sterilize in sequence to obtain a fragrant UV-cured contact lens material.

[0070] Experimental Example 1

[0071] Perform the following tests on the fragrant UV-cured contact lens materials prepared in Examples 1 - 4:

[0072] The standard for cytotoxicity testing: ISO9363-1 (the test results are divided into levels 0 - 4, and the lower the value, the better the material safety);

[0073] The standard for water content testing: "Measurement of water content / evaporation loss of hydrogel contact lenses by the gravimetric method" recorded in Section 4.5 of GB / T 11417.7-2012;

[0074] The standard for oxygen permeability testing: Polarography method in Section 4.4.3 of GB / T 11417.7-2012;

[0075] The standard for light transmittance testing: The testing method recorded in Section 4.4 refractive index of GB / T 11417.7-2012;

[0076] The standard for contact angle testing: The testing method recorded in Section 4.6 contact angle of GB / T 11417.7-2012; The test results are shown in Table 1.

[0077] Table 1 Test results

[0078]

[0079]

[0080] It can be seen from Table 1 that the cytotoxicity of the scented UV light-curing contact lens materials prepared by the present invention is all level 0, the material safety is good, the added α-bisabolol, vanillin, and apigenin components will not cause irritation to the human body, and the safety is relatively high; in addition, the contact lens materials have excellent parameters such as water content and oxygen permeability, which can meet the requirements of long-term wearing comfort, and based on the addition of effective components, can also alleviate dry eye syndrome, eye inflammation, etc.; during long-term wearing, the contact lens material will slowly release fragrance, and the fragrance is mild and non-irritating, which can make the wearer feel physically and mentally happy.

[0081] The various embodiments in this specification are described in a progressive manner, and each embodiment focuses on the differences from other embodiments. The same or similar parts between the various embodiments can be referenced to each other.

[0082] The above description of the disclosed embodiments enables one skilled in the art to implement or use the present invention. Various modifications to these embodiments will be apparent to one skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to the embodiments shown herein, but rather to the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A fragrant UV - curable contact lens material, characterized in that, It is prepared from the following raw materials in parts by mass: 30 to 40 parts of siloxane monomer, 50 to 80 parts of hydrophilic monomer, 0.01 to 0.1 part of nano-capsule, 0.5 to 1.5 parts of cross-linking agent, 0.2 to 0.8 part of ultraviolet absorber, 0.5 to 1.5 parts of initiator; The nano-capsule includes a wall material and a core material, and the core material of the nano-capsule includes α-bisabolol, vanillin, and apigenin.

2. The fragrant UV curable contact lens material according to claim 1, characterized in that The preparation method of the nano-capsule includes the following steps: 1) Dissolve β-cyclodextrin in water to obtain a β-cyclodextrin aqueous solution; Dissolve α-bisabolol, vanillin, and apigenin in ethanol to obtain a mixed solution; 2) Drop the mixed solution into the β-cyclodextrin aqueous solution, and perform an inclusion reaction to obtain an inclusion complex solution; 3) Subject the inclusion complex solution to high-pressure homogenization, and then perform spray drying to obtain nano-capsules.

3. A fragrant UV-curable contact lens material according to claim 2, characterized in that, The mass concentration of β-cyclodextrin in the β-cyclodextrin aqueous solution is 60 to 80 g / L; The total molar ratio of α-bisabolol, vanillin, and apigenin to β-cyclodextrin is 0.7 to 1:1; The molar ratio of α-bisabolol, vanillin, and apigenin is 1 to 5:0.3 to 0.5:2 to 5; The volume ratio of the mixed solution to the β-cyclodextrin aqueous solution is 1 to 5:

10.

4. The fragrant UV-curable contact lens material according to claim 2 or 3, characterized in that, In step 2), the time of the inclusion reaction is 1 to 2 h, and the temperature of the inclusion reaction is 50 to 60 °C.

5. A fragrant UV - curable contact lens material according to claim 4, characterized in that, The pressure of the high-pressure homogenization is 20 to 50 MPa, the temperature of the high-pressure homogenization is 25 to 40 °C, and the number of high-pressure homogenization times is 2 to 3 times; The temperature of the spray drying is <80 °C; The particle size of the nano-capsule is 20 to 250 nm.

6. A scented UV - curable contact lens material according to any one of claims 1 to 3 and 5, characterized in that, The siloxane monomer includes one or more of methacryloxypropyl tris(trimethylsiloxy)silane, vinyl-terminated polydimethylsiloxane, 1,3-bis(3-methacryloxypropyl)tetrakis(trimethylsiloxy)disiloxane, and N-(3-methacryloxy-2-hydroxypropyl)-3-aminopropyltriethoxysilane.

7. A fragrant UV - curable contact lens material according to claim 6, characterized in that, The hydrophilic monomer includes one or more of N-vinylpyrrolidone, hydroxyethyl methacrylate, butyl methacrylate, methacrylic acid, dimethylaminoethyl methacrylate, and glycerol methacrylate.

8. The fragrance-containing UV-curable contact lens material according to claim 7, characterized in that, The cross-linking agent includes one or more of ethylene glycol dimethacrylate, tetraethylene glycol dimethacrylate, and trimethylolpropane trimethacrylate; The ultraviolet absorber includes benzotriazole ultraviolet absorbers and / or triazine ultraviolet absorbers; The initiator includes one or more of bis(2,4,6-trimethylbenzoyl)phenylphosphine oxide, 2,4,6-trimethylbenzoyl-diphenylphosphine oxide, and 2-hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone.

9. A preparation method of a fragrant UV-curable contact lens material according to any one of claims 1 to 8, characterized in that, It includes the following steps: Mix the siloxane monomer, hydrophilic monomer, nano-capsule, cross-linking agent, ultraviolet absorber, and initiator, and then successively perform mold injection, UV light curing, soaking, and sterilization to obtain a fragrant UV light-curing contact lens material.

10. Use of the fragrant UV light-curing contact lens material prepared by the preparation method described in claim 9 in the preparation of contact lenses.

Images