Application of wheat TaMIPS gene in resistance to Fusarium head blight and stem rot

By overexpressing or editing the TaMIPS gene in wheat to regulate inositol metabolism, the problem of inconsistent resistance among wheat varieties has been solved, achieving high-efficiency resistance to Fusarium head blight and stem rot, thus ensuring safe wheat production.

CN120290541BActive Publication Date: 2026-06-30NANJING AGRICULTURAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
NANJING AGRICULTURAL UNIVERSITY
Filing Date
2025-04-14
Publication Date
2026-06-30

AI Technical Summary

Technical Problem

Existing wheat varieties show inconsistent resistance to Fusarium head blight and stem rot, and the accumulation of DON toxin is closely related to the diseases, affecting safe wheat production and food security.

Method used

By overexpressing or editing the TaMIPS gene in wheat, the expression or activity of inositol phosphate synthase is enhanced, inositol metabolism is regulated, the pathogenicity of DON toxin is weakened, and wheat resistance to Fusarium head blight and stem rot is improved.

Benefits of technology

It significantly enhances wheat's resistance to Fusarium head blight and stem rot, reduces disease severity, decreases DON toxin accumulation, and improves the disease resistance stability of wheat varieties.

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Abstract

This invention discloses the application of the wheat gene TaMIPS in regulating resistance to Fusarium head blight and stem rot. Through the creation of wheat materials, it was demonstrated that overexpression of the TaMIPS gene significantly enhances wheat resistance to Fusarium head blight and stem rot, while mutants exhibit decreased disease resistance. Furthermore, this invention utilizes gene editing technology to optimize the promoter region of the TaMIPS gene, removing the inhibitory effect of the upstream non-coding open reading frame (uORF) on its expression, thereby significantly increasing the expression level of the TaMIPS gene-encoded protein and effectively enhancing wheat disease resistance.
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