In-vivo cornea biomechanical property measuring device and application

Abstract

The invention discloses an in-vivo cornea biomechanical characteristic measuring device and application, and belongs to the technical field of ophthalmology biomechanical measurement, the in-vivo cornea biomechanical characteristic measuring device comprises a negative pressure adsorption module and an imaging module; wherein a single-side opening groove is formed in the negative pressure adsorption module; the open side of the open slot is adsorbed on the limbus of the cornea; the open slot and the front surface of the cornea form a closed cavity; the closed cavity is used for receiving external negative pressure, so that the cornea is stressed to expand; the external negative pressure is monotonically changed and is changed once every preset time, so that the cornea stress is changed and the morphology is changed; by means of the designed negative pressure adsorption module, stable pressurization of external negative pressure on the closed cavity instead of instantaneous pressure can be achieved, so that the cornea is stably stressed to generate morphology changes, the stable morphology is kept instead of the transient morphology, and the influence of cornea inertia and viscoelasticity is effectively avoided; and accurate measurement of the static biomechanical characteristics of the cornea can be realized in a non-invasive manner.

Description

Technical Field

[0001] The present invention belongs to the technical field of ophthalmic biomechanical measurement, and more specifically, relates to a device and application for measuring the biomechanical properties of the in-vivo cornea. Background Art

[0002] The cornea is an important part of the eyeball, and its biomechanical properties are crucial for maintaining the normal shape and function of the eyeball. With the increasing incidence of ophthalmic diseases such as myopia year by year, the application of ophthalmic medical technologies such as corneal refractive surgery has become increasingly widespread. However, the effect of corneal refractive surgery and postoperative recovery are closely related to the biomechanical properties of the cornea. The biomechanical properties of the cornea mainly refer to the stress-strain relationship of the cornea, that is, the relationship between corneal topography and corneal force. Traditional methods for detecting the biomechanical properties of the cornea mostly use ex-vivo measurement methods, such as corneal stretching method, corneal inflation method, etc. However, these methods destroy the inherent physiological environment and structural characteristics of the cornea and cannot fully reflect the biomechanical properties of the cornea in the physiological environment.

[0003] In recent years, with the continuous progress of medical technology, the in-vivo measurement technology of corneal biomechanics has gradually become a research hotspot. Measuring the biomechanical properties of the cornea in-vivo through non-invasive or minimally invasive methods can not only provide more accurate pre-operative evaluation and post-operative monitoring means for ophthalmic medical technologies such as corneal refractive surgery, but also help to deeply understand the physiological and pathological processes of the cornea and provide a scientific basis for the treatment and prevention of related ophthalmic diseases. Therefore, developing an efficient, accurate, and non-invasive in-vivo measurement technology for corneal biomechanics has important clinical significance and scientific value.

[0004] Clinically, an ocular response analyzer (ORA) is usually used to measure the biomechanical properties of the cornea in-vivo. By applying an air pulse to the cornea to change the shape of the corneal surface, the relationship between corneal topography and its force is reflected. However, the air pulse can only apply instantaneous pressure to the cornea, and the corresponding corneal topography is only a transient topography. However, the transient topography is easily affected by corneal inertia and viscoelasticity, and the measurement of the static biomechanical properties of the cornea cannot be achieved, and the true biomechanical properties of the cornea cannot be comprehensively and accurately reflected. Summary of the Invention

[0005] In view of the above deficiencies or improvement requirements of the prior art, the present invention provides a device and application for measuring the biomechanical properties of the in-vivo cornea, and its purpose is to accurately measure the static biomechanical properties of the cornea non-invasively.

[0006] To achieve the above object, in a first aspect, the present invention provides a device for measuring the biomechanical properties of the in-vivo cornea, including:

[0007] A negative pressure adsorption module is provided with a single-sided opening groove; one side where the opening groove opens is used as the first side of the negative pressure adsorption module for adsorbing on the corneal limbus of the cornea; the opening groove and the anterior surface of the cornea form a sealed cavity; the sealed cavity is used to receive the action of external negative pressure, so that the cornea is stressed and expands; the external negative pressure changes monotonically and changes once every preset time, so that the cornea is stressed and undergoes morphological changes.

[0008] An imaging module is used to collect three-dimensional morphological images of the cornea under different forces, forming a set of three-dimensional morphological images of the cornea carrying corneal force information to characterize the biomechanical properties of the cornea.

[0009] Further preferably, the above-mentioned in-vivo corneal biomechanical property measuring device further includes: a negative pressure module for applying negative pressure to the sealed cavity.

[0010] Further preferably, a negative pressure pipeline is further arranged on the opening groove for introducing external negative pressure into the sealed cavity.

[0011] Further preferably, the contact area between the first side of the negative pressure adsorption module and the corneal limbus is a toroidal surface.

[0012] Further preferably, the side of the opening groove opposite to the cornea is used as the second side of the negative pressure adsorption module, and a transparent module is arranged thereon; the above-mentioned imaging module is used to collect three-dimensional morphological images of the cornea under different forces through the transparent module.

[0013] Further preferably, the above-mentioned in-vivo corneal biomechanical property measuring device further includes: an intraocular pressure measuring module for measuring the intraocular pressure of the cornea under different forces.

[0014] In a second aspect, the present invention provides a method for calculating corneal biomechanical parameters, including:

[0015] Respectively extract the corresponding corneal surface contour features from each three-dimensional morphological image in the set of three-dimensional morphological images of the cornea carrying corneal force information as its true result; wherein, the set of three-dimensional morphological images of the cornea is measured by the above-mentioned in-vivo corneal biomechanical property measuring device;

[0016] Based on the three-dimensional morphological image of the cornea without morphological changes, establish a three-dimensional geometric model of the cornea;

[0017] Import the three-dimensional corneal geometric model into finite element analysis software, and apply different force information carried in the three-dimensional corneal topography image set to the three-dimensional corneal geometric model respectively to obtain the simulation results of the corresponding corneal surface contour features under the constraint of the corneal constitutive equation; by minimizing the absolute value of the difference between the simulation results of each corneal surface contour feature and the corresponding real results, use the finite element analysis method to inversely analyze the corneal biomechanical parameters in the corneal constitutive equation.

[0018] Further preferably, the corneal surface contour features include: anterior corneal surface contour features or posterior corneal surface contour features; wherein, the anterior corneal surface contour features include: the spatial volume enclosed by the anterior corneal surface and the plane where the corneal limbus is located; the posterior corneal surface contour features include: the spatial volume enclosed by the posterior corneal surface and the plane where the corneal limbus is located.

[0019] Further preferably, the corneal biomechanical parameters include: Young's modulus and shear modulus of the cornea.

[0020] Further preferably, the three-dimensional topography image of the cornea without morphological changes is measured by the above-mentioned in-vivo corneal biomechanical property measurement device; during the measurement, the external negative pressure acting on the in-vivo corneal biomechanical property measurement device is consistent with the ambient pressure.

[0021] In a third aspect, the present invention provides a corneal biomechanical parameter calculation device, including: a memory and a processor, the memory stores a computer program, and when the processor executes the computer program, it executes the method provided in the second aspect of the present invention.

[0022] In a fourth aspect, the present invention provides a corneal biomechanical parameter calculation system, including: the in-vivo corneal biomechanical property measurement device provided in the first aspect of the present invention and the corneal biomechanical parameter calculation device provided in the third aspect of the present invention.

[0023] In a fifth aspect, the present invention further provides a computer-readable storage medium, the computer-readable storage medium includes a stored computer program, wherein, when the computer program is run by a processor, it controls the device where the storage medium is located to execute the method provided in the second aspect of the present invention.

[0024] In a sixth aspect, the invention further provides a computer program product, including a computer program / instructions, when the computer program / instructions are executed by a processor, they implement the method provided in the second aspect of the present invention.

[0025] Generally speaking, through the above technical solutions conceived by the present invention, the following beneficial effects can be achieved:

[0026] 1. The present invention provides a device for measuring the biomechanical properties of the in-vivo cornea. A unilateral opening groove is provided on the negative pressure adsorption module; one side of the opening groove is used for adsorbing on the corneal limbus of the cornea; the opening groove and the anterior corneal surface form a sealed cavity; the sealed cavity is used to receive the action of external negative pressure, so that the cornea is stressed and expands; the external negative pressure changes monotonically and changes once every preset time, so that the stress on the cornea changes and generates topographical changes; the present invention controls the pressure difference inside and outside the cornea through negative pressure, realizes a non-invasive in-vivo corneal expansion process, and can realize the stable pressurization of the sealed cavity by the external negative pressure rather than instantaneous pressure through the designed negative pressure adsorption module, so that the cornea is stably stressed to generate topographical changes and maintain a stable topography rather than a transient topography, effectively avoiding the influence of corneal inertia and viscoelasticity, and can non-invasively realize the accurate measurement of the static biomechanical properties of the cornea.

[0027] 2. Further, in the device for measuring the biomechanical properties of the in-vivo cornea provided by the present invention, a negative pressure pipeline is provided on the negative pressure adsorption module, which can simply and conveniently introduce external negative pressure into the sealed cavity.

[0028] 3. The present invention provides a method for calculating corneal biomechanical parameters. Based on the device for measuring the biomechanical properties of the in-vivo cornea provided in the first aspect of the present invention, the three-dimensional topographical images of the cornea under different forces can be accurately measured, and then the accurate inverse analysis of corneal biomechanical parameters can be realized.

[0029] 4. Further, in the method for calculating corneal biomechanical parameters provided by the present invention, the corneal surface contour features include the space volume enclosed by the anterior corneal surface and the plane where the corneal limbus is located or the space volume enclosed by the posterior corneal surface and the plane where the corneal limbus is located, which can obtain more comprehensive and rich corneal surface contour information and further improve the accuracy of corneal biomechanical parameter calculation.

[0030] 5. The present invention solves the problem that there is a lack of correlation between clinical medical equipment and classical corneal mechanical parameters. Among them, the measurement of the biomechanical properties of the in-vivo cornea itself is a part of the ophthalmic surgical procedure, the measurement process is simple, and the calculated corneal biomechanical parameters are more intuitive and accurate. BRIEF DESCRIPTION OF THE DRAWINGS

[0031] Figure 1 Schematic diagram of a device for measuring the biomechanical properties of the in-vivo cornea provided by an embodiment of the present invention;

[0032] Figure 2 Flow chart of a method for calculating corneal biomechanical parameters provided by an embodiment of the present invention;

[0033] Figure 3 Inverse analysis flow chart of corneal biomechanical parameters provided by an embodiment of the present invention;

[0034] Figure 4 A corneal biomechanical parameter calculation system provided by an embodiment of the present invention;

[0035] Figure 5 A specific schematic diagram of an in-vivo corneal biomechanical property measuring device provided by an embodiment of the present invention. Specific implementation manners

[0036] In order to make the objectives, technical solutions and advantages of the present invention clearer, the present invention will be further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention. In addition, the technical features involved in the various embodiments of the present invention described below can be combined with each other as long as they do not conflict with each other.

[0037] To achieve the above objective, in a first aspect, the present invention provides an in-vivo corneal biomechanical property measuring device, including:

[0038] A negative pressure adsorption module, on which a single-sided opening groove is provided; one side of the opening of the opening groove serves as the first side of the negative pressure adsorption module and is used to adsorb on the corneal limbus of the cornea; the opening groove and the anterior corneal surface form a sealed cavity; the sealed cavity is used to receive the action of an external negative pressure, so that the cornea is stressed and expands; the external negative pressure changes monotonically and changes once every preset time, so that the cornea is stressed and undergoes a morphological change;

[0039] An imaging module, which is used to collect three-dimensional morphological images of the cornea under different forces, and form a set of corneal three-dimensional morphological images carrying corneal force information to characterize the corneal biomechanical properties.

[0040] As Figure 1 shown is a schematic diagram of the in-vivo corneal biomechanical property measuring device provided by the present invention. It should be noted that the external negative pressure can gradually increase or gradually decrease, so that the pressure in the sealed cavity changes. Specifically, when the external negative pressure gradually increases, the pressure in the sealed cavity decreases correspondingly (the negative pressure increases correspondingly), so that the expansion intensity of the cornea towards the second side of the negative pressure adsorption module increases. When the external negative pressure gradually decreases, the pressure in the sealed cavity also increases correspondingly (the negative pressure decreases correspondingly), so that the expansion intensity of the cornea towards the second side of the negative pressure adsorption module decreases.

[0041] In an alternative embodiment, the side of the opening groove opposite to the cornea serves as the second side of the negative pressure adsorption module, and a transparent module is provided thereon; wherein, the transparent module can be any transparent module, such as a lens, a transparent film, glass, etc., preferably a thin material with a very high light transmittance; at this time, the imaging module is used to collect three-dimensional topography images of the cornea under different forces through the transparent module. It should be noted that this is only one of the embodiments, and the imaging module can also be arranged inside the opening groove, for example, on the inner wall of the second side of the negative pressure adsorption module, which is not limited herein.

[0042] In an alternative embodiment, the above-mentioned in-vivo corneal biomechanical property measuring device further includes: a negative pressure module for applying negative pressure to the sealed cavity. It should be noted that the negative pressure module can be a vacuum pump, a temperature module, etc., which is not limited herein. The vacuum pump provides negative pressure by pumping out the gas in the sealed cavity, so that the pressure in the sealed cavity is less than the ambient pressure. The temperature module can provide negative pressure by reducing the temperature in the sealed cavity.

[0043] In an alternative embodiment, the above-mentioned negative pressure adsorption module further includes a negative pressure pipeline arranged on the opening groove for introducing external negative pressure into the sealed cavity. At this time, the negative pressure module is preferably a vacuum pump, and the vacuum pump applies negative pressure to the sealed cavity through the negative pressure pipeline.

[0044] Preferably, the contact area between the first side of the negative pressure adsorption module and the corneal limbus is an annular curved surface to achieve close contact.

[0045] In an alternative embodiment, the preset time is 10 s to 2 min, preferably 10 s to 60 s, to ensure the stability of the negative pressure in the sealed cavity.

[0046] It should be noted that the above-mentioned imaging module is an image acquisition device. In an alternative embodiment, the imaging module has a three-dimensional imaging function, such as a depth camera, an optical coherence tomography scanner (OCT), a Scheimpflug imager, a corneal topographer, etc. Preferably, the imaging module is an optical coherence tomography scanner. In an alternative embodiment, every time the force on the cornea changes, the imaging module collects a three-dimensional topography image of the cornea.

[0047] It should be noted that for each application of an external negative pressure, the pressure in the sealed cavity can be constantly maintained at the corresponding pressure. Preferably, in order to ensure the safety of the cornea, in an alternative embodiment, the above external negative pressure has a safety upper limit threshold, which is specifically less than or equal to the negative pressure limit that the cornea can withstand. In another alternative embodiment, there is an obstacle inside the negative pressure adsorption module for restricting the maximum deformation range during the negative pressure adsorption process of the cornea. Preferably, the obstacle is a transparent baffle arranged in the sealed cavity, preferably an arc-shaped baffle with the opening direction facing the cornea; when the negative pressure adsorption module further includes a negative pressure pipeline, the negative pressure pipeline is located between the obstacle and the first side of the negative pressure adsorption module.

[0048] It should be noted that the degree of corneal expansion is different under different external negative pressures. The corneal topographical changes include but are not limited to vertical height, vertex displacement, and curvature changes.

[0049] In an alternative embodiment, the above in-vivo corneal biomechanical property measuring device further includes: an intraocular pressure measuring module for measuring the intraocular pressure of the cornea under different forces, which is more convenient for clinical operation and application.

[0050] In a second aspect, the present invention provides a method for calculating corneal biomechanical parameters, including:

[0051] Extracting the corresponding corneal surface contour features from each corneal three-dimensional topographical image in the corneal three-dimensional topographical image set carrying corneal force information as its true results; wherein, the corneal three-dimensional topographical image set is measured by the above in-vivo corneal biomechanical property measuring device;

[0052] Based on the three-dimensional topographical image of the cornea without morphological changes, establishing a corneal three-dimensional geometric model;

[0053] Importing the corneal three-dimensional geometric model into finite element analysis software, and applying different force information carried in the corneal three-dimensional topographical image set to the corneal three-dimensional geometric model respectively to obtain the simulation results of the corresponding corneal surface contour features under the constraints of the corneal constitutive equation; by minimizing the absolute value of the difference between the simulation results of each corneal surface contour feature and the corresponding true results, using the finite element analysis method to inversely analyze the corneal biomechanical parameters in the corneal constitutive equation.

[0054] It should be noted that there are various methods for establishing the corneal three-dimensional geometric model. The corneal three-dimensional geometric model can be established by using finite element analysis software, or can also be established by using Solidworks, C4D, 3Dmax, CAD, etc., which is not limited here.

[0055] The finite element analysis software can be any finite element analysis software, such as ANSYS, ABAQUS, COMSOL, etc., which is not limited here.

[0056] In an alternative embodiment, the above corneal biomechanical parameters include: Young's modulus and shear modulus of the cornea.

[0057] It should be noted that there can be various corneal surface profile features, such as vertical height, vertex displacement, curvature, etc. Specifically, it can be the offset of the reference point on the anterior corneal surface in the image relative to the initial position of the cornea, the offset of the reference point on the anterior corneal surface in the image relative to the plane where the corneal limbus is located, the offset of the reference point on the posterior corneal surface relative to the initial position of the cornea, the offset of the reference point on the posterior corneal surface in the image relative to the plane where the corneal limbus is located, etc. There is no limitation here. In order to obtain more comprehensive and rich corneal surface profile information, preferably, in an alternative embodiment, volume is used for feature characterization; the corneal surface profile features include: anterior corneal surface profile features or posterior corneal surface profile features; wherein, the anterior corneal surface profile features include: the volume of the space enclosed by the anterior corneal surface and the plane where the corneal limbus is located; the posterior corneal surface profile features include: the volume of the space enclosed by the posterior corneal surface and the plane where the corneal limbus is located.

[0058] It should be noted that the three-dimensional topographic image of the cornea without morphological changes can be acquired by using any existing corneal acquisition device, such as an optical coherence tomograph, etc.

[0059] Preferably, in an alternative embodiment, the three-dimensional topographic image of the cornea without morphological changes is measured by using the in-vivo corneal biomechanical property measurement device provided in the first aspect of the present invention; during the measurement, the external negative pressure acting on the in-vivo corneal biomechanical property measurement device is consistent with the ambient pressure, that is, the external negative pressure is 0; at this time, the cornea is in its initial topography and does not undergo morphological changes.

[0060] It should be noted that there are various methods for minimizing the absolute value of the difference between the simulation results and the corresponding real results of each corneal surface profile feature, such as the least squares method, Newton iteration method, gradient descent method, etc. When the absolute value of the difference between the simulation results and the corresponding real results of the corneal surface profile feature is less than or equal to a preset value, the final corneal biomechanical parameters are obtained.

[0061] To further illustrate the corneal biomechanical parameter calculation method provided by the present invention, a specific embodiment is described in detail below:

[0062] As Figure 2 described, the corneal biomechanical parameter calculation method provided in this embodiment includes:

[0063] A1. Extract the corresponding corneal surface contour features from each corneal three-dimensional topography image in the corneal three-dimensional topography image set carrying corneal force information as its true result. Among them, the corneal three-dimensional topography image set is measured by the in-vivo corneal biomechanical property measurement device provided in the first aspect of the present invention.

[0064] In this embodiment, the corneal surface contour feature is the corneal anterior surface contour feature, that is, the spatial volume enclosed by the corneal anterior surface and the plane where the corneal limbus is located. Specifically, for each corneal topography image, take any point on the corneal optical axis as the origin, the corneal optical axis as the z-axis, and the plane passing through the origin and perpendicular to the z-axis as the xy-plane to establish the same xyz coordinate system. Randomly collect pixel points within the range where the distance from the z-axis is less than or equal to k mm, and obtain the corresponding spatial coordinates. Denote the i-th spatial coordinate among them as (x i , y i , z i ). Among them, k is the distance from the corneal limbus to the corneal optical axis, and the value in this embodiment is 4.5 mm. In this embodiment, the number of pixel points collected is greater than the preset number m. In this embodiment, m takes the value of 524288 (i.e., 1024×512). Integrate the collected spatial coordinates to obtain the spatial volume enclosed by the corneal anterior surface and the plane where the corneal limbus is located as:

[0065]

[0066] A2. Based on the three-dimensional topography image of the cornea without morphological changes, establish a corneal three-dimensional geometric model.

[0067] Specifically, take any point on the corneal optical axis as the origin, the corneal optical axis as the z-axis, and the plane passing through the origin and perpendicular to the z-axis as the xy-plane to establish the xyz coordinate system.

[0068] Construct corresponding smooth surface equations for the corneal anterior surface topography and the corneal posterior surface topography in the corneal topography image of the cornea without morphological changes as the corneal anterior surface topography model and the corneal posterior surface topography model. Among them, the smooth surface equation includes but is not limited to spherical surface, ellipsoidal surface, hyperbolic surface, Zernike surface equation, etc.

[0069] Form a closed entity with the corneal anterior surface topography model and the corneal posterior surface topography model as the corneal three-dimensional geometric model.

[0070] A3. Import the three-dimensional corneal geometric model into finite element analysis software, and apply different force information carried in the three-dimensional corneal topography image set to the three-dimensional corneal geometric model respectively to obtain the simulation results of the corresponding corneal surface contour features under the constraint of the corneal constitutive equation; by minimizing the absolute value of the difference between the simulation results of each corneal surface contour feature and the corresponding real results, use the finite element analysis method to inversely analyze the corneal biomechanical parameters in the corneal constitutive equation.

[0071] It should be noted that the corneal constitutive equation is a parametric corneal constitutive equation, including corneal biomechanical parameters.

[0072] Preferably, in the above inverse analysis process, there are also the following boundary conditions, including: fixed constraints, symmetric boundary conditions, etc. applied at positions within a certain radius range of the cornea. Among them, the radius range of the cornea is determined by the distance from the corneal limbus to the corneal optical axis.

[0073] As Figure 3 shown, by iteratively minimizing the absolute value of the difference between the simulation results of each corneal surface contour feature and the corresponding real results, the iterative method includes but is not limited to the Newton iterative method. When the absolute value of the difference between the simulation results of the corneal surface contour feature and the corresponding real results is less than or equal to the preset volume d mm 3 , the solution of the corneal biomechanical parameters is completed, and the solved corneal biomechanical parameters are output. d in this embodiment is 10um 3 .

[0074] The finite element analysis software in this embodiment is COMSOL. The corneal biomechanical parameters in this embodiment include: physical quantities such as Young's modulus, shear modulus, bulk modulus, stiffness, stress-strain relationship, etc. of the cornea.

[0075] In this embodiment, according to the solution target requirements, the corresponding corneal constitutive model is selected; the corneal constitutive model includes but is not limited to isotropic model, anisotropic model, transversely isotropic model, hyperelastic model, etc.

[0076] The present invention solves the problem of the lack of correlation between clinical medical equipment and classical corneal mechanical parameters. Its measurement method itself is a part of the ophthalmic surgery process, the method is simple, and the measured parameters are more intuitive and accurate. This method is not limited to the diagnosis of various ophthalmic diseases, such as keratoconus, glaucoma, corneal ectasia after refractive surgery, etc.

[0077] In the third aspect, the present invention provides a corneal biomechanical parameter calculation device, including: a memory and a processor, the memory stores a computer program, and when the processor executes the computer program, it executes the method provided in the second aspect of the present invention.

[0078] The related technical solutions are the same as the corneal biomechanical parameter calculation method provided in the second aspect of the present invention, which will not be elaborated here.

[0079] Fourthly, the present invention provides a corneal biomechanical parameter calculation system, including: the in-vivo corneal biomechanical property measurement device provided in the first aspect of the present invention and the corneal biomechanical parameter calculation device provided in the third aspect of the present invention.

[0080] Specifically, in an optional embodiment, as Figure 4 shown, the corneal biomechanical parameter calculation system 8 includes: an in-vivo corneal biomechanical property measurement device and a corneal biomechanical parameter calculation device 4; wherein, the in-vivo corneal biomechanical property measurement device includes: an imaging module 1 and a negative pressure adsorption module 2; the specific schematic diagram of the in-vivo corneal biomechanical property measurement device in this embodiment is as Figure 5 shown. The corneal biomechanical parameter calculation device is a computer control device, including: a memory 5 and a processor 6; the memory 5 contains a computer program for executing the corneal biomechanical parameter calculation method provided in the second aspect of the present invention.

[0081] The imaging module 1 captures the real-time topography of the human eye 7, and collects three-dimensional topography images of the cornea under different forces under the negative pressure adsorption device 2, constitutes a set of corneal three-dimensional topography images carrying corneal force information, and imports them into the processor 6. When the processor 6 executes the computer program contained in the memory 5, it executes the method provided in the second aspect of the present invention to obtain corneal biomechanical parameters. Among them, the negative pressure adsorption device 2 can effectively fix the anterior surface area of the patient's cornea and can effectively control the pressure stability in the negative pressure adsorption.

[0082] Furthermore, the above in-vivo corneal biomechanical property measurement device further includes an intraocular pressure measurement device 3 for measuring the physiological intraocular pressure IOP inside the cornea in real time during the negative pressure adsorption process.

[0083] The related technical solutions are the same as the in-vivo corneal biomechanical property measurement device provided in the first aspect of the present invention and the corneal biomechanical parameter calculation device provided in the third aspect of the present invention, which will not be elaborated here.

[0084] Fifthly, the present invention further provides a computer-readable storage medium, the computer-readable storage medium includes a stored computer program, wherein, when the computer program is run by a processor, it controls the device where the storage medium is located to execute the method provided in the second aspect of the present invention.

[0085] The related technical solutions are the same as the corneal biomechanical parameter calculation method provided in the second aspect of the present invention, which will not be elaborated here.

[0086] In a sixth aspect, the invention also provides a computer program product, including a computer program / instructions, which when executed by a processor implement the method provided in the second aspect of the present invention.

[0087] The related technical solutions are the same as the corneal biomechanical parameter calculation method provided in the second aspect of the present invention, and will not be elaborated here.

[0088] Those skilled in the art can easily understand that the above are only preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent replacements, and improvements made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. An in-vivo corneal biomechanical property measurement device, characterized in that Comprising: A negative pressure adsorption module, on which a one-sided opening groove is provided; one side where the opening of the opening groove is located serves as the first side of the negative pressure adsorption module and is used for adsorbing on the corneal limbus of the cornea; the opening groove and the anterior corneal surface form a sealed cavity; the sealed cavity is used to receive the action of an external negative pressure, so that the cornea is stressed and expands; the external negative pressure changes monotonically and changes once every preset time, so that the cornea is stressed and undergoes morphological changes. An imaging module, which is used to collect three-dimensional morphological images of the cornea under different forces, and form a set of three-dimensional morphological images of the cornea carrying corneal force information to characterize the biomechanical properties of the cornea.

2. The in-vivo corneal biomechanical property measuring device according to claim 1, characterized in that, A negative pressure pipeline is further provided on the opening groove and is used to introduce the external negative pressure into the sealed cavity.

3. The in-vivo corneal biomechanical property measurement device according to claim 1, wherein The contact area between the first side of the negative pressure adsorption module and the corneal limbus is a toroidal surface.

4. The in-vivo corneal biomechanical property measurement device according to any one of claims 1-3, characterized in that, The side of the opening groove opposite to the cornea serves as the second side of the negative pressure adsorption module, and a transparent module is provided thereon; the imaging module is used to collect three-dimensional morphological images of the cornea under different forces through the transparent module.

5. A method for calculating corneal biomechanical parameters, characterized in that, Comprising: Extract the corresponding corneal surface contour features from each three-dimensional morphological image of the cornea in the set of three-dimensional morphological images of the cornea carrying corneal force information as its true result; wherein, the set of three-dimensional morphological images of the cornea is measured by the in-vivo corneal biomechanical property measuring device according to any one of claims 1-4. Based on the three-dimensional morphological image of the cornea without morphological changes, establish a three-dimensional corneal geometric model. Import the three-dimensional corneal geometric model into finite element analysis software, and apply different force information carried in the set of three-dimensional morphological images of the cornea to the three-dimensional corneal geometric model respectively to obtain the simulation results of the corresponding corneal surface contour features under the constraint of the corneal constitutive equation; by minimizing the absolute value of the difference between the simulation results of each corneal surface contour feature and the corresponding true result, use the finite element analysis method to inversely analyze the corneal biomechanical parameters in the corneal constitutive equation.

6. The corneal biomechanical parameter calculation method according to claim 5, characterized in that The corneal surface contour features include: anterior corneal surface contour features or posterior corneal surface contour features; the anterior corneal surface contour features include: the space volume enclosed by the anterior corneal surface and the plane where the corneal margin is located; the posterior corneal surface contour features include: the space volume enclosed by the posterior corneal surface and the plane where the corneal margin is located.

7. The method for calculating corneal biomechanical parameters according to claim 5 or 6, characterized in that, The three-dimensional morphological image of the cornea without morphological changes is measured by the in-vivo corneal biomechanical property measuring device according to any one of claims 1-4; during the measurement, the external negative pressure acting on the in-vivo corneal biomechanical property measuring device is consistent with the ambient pressure.

8. An apparatus for calculating corneal biomechanical parameters, characterized in that, Comprising: A memory and a processor, the memory stores a computer program, and when the processor executes the computer program, it executes the method according to any one of claims 5-7.

9. A corneal biomechanical parameter calculation system, characterized in that, Comprising: The in-vivo corneal biomechanical property measuring device according to any one of claims 1-4 and the corneal biomechanical parameter calculation device according to claim 8.

10. A computer-readable storage medium, characterized in that, The computer-readable storage medium includes a stored computer program, wherein when the computer program is run by a processor, it controls the device where the storage medium is located to execute the method according to any one of claims 5 to 7.

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