In-vivo tissue sampling device and sampling assembly thereof

Abstract

The invention discloses an in-vivo tissue sampling device and a sampling assembly thereof. The in-vivo tissue sampling device comprises a handle, an outer sleeve, a push-pull cable and a sampling assembly, wherein the handle comprises a handle body and a sliding block. The sampling assembly comprises a forceps head, a forceps head seat and a push-pull rod, the forceps head seat is provided with fins, the tail ends of forceps head handles are provided with concave notches, the concave notches are provided with cylindrical protrusions, the sum of the thicknesses of the two forceps head handles is equal to the distance between the fins, the push-pull rod is provided with a tail end rotating shaft, and a connecting piece with the thickness delta equal to the depth of the concave notches is connected to the outer sides of the push-pull rod and the forceps head handles to form a rotating pair. The tong head handles are arranged in a back-to-back mode, concave notches of the tong head handles are outward, the tong head handles are embedded into the tong head seat after being assembled with the connecting piece and the push-pull rod through cylindrical protrusions and tail end rotating shafts, the outer side faces w11 of the tong head handles and the outer side faces w21 of the connecting piece are attached to the inner side surfaces of fins of the tong head seat, and tong head rotating shafts are fixed to the fins. And the tong head rotating shaft penetrates through the upper parts of the back-to-back tong head handles and forms a revolute pair with the tong head handles and the fins.

Description

Technical Field

[0001] The present invention relates to a tissue sampling instrument, and particularly to an in-vivo tissue sampling device and its sampling assembly. Background Art

[0002] Existing in-vivo tissue sampling devices, referring to Figure 1 , generally include a bendable spring tube 21, a push-pull cable 22 passing through the spring tube 21, a handle 1, and a sampling assembly 3. The in-vivo tissue sampling device is a minimally invasive surgical instrument, mainly used for collecting tissue samples in the human body for pathological examination. When in use, the in-vivo tissue sampling device often needs to pass through a small lumen smoothly to reach the position of the tissue specimen to be collected. Taking the lungs as an example, the in-vivo tissue sampling device needs to pass through the main bronchus, bronchi, etc. in sequence to complete the collection of the tissue specimen. The main bronchus and bronchi are very small, and only an in-vivo tissue sampling device with an outer diameter of 1.8 mm and 1.0 mm can enter and pass through. An in-vivo tissue sampling device with an outer diameter of 2.3 mm is too large to pass through the surgical channel of the bronchoscope and cannot be used for lung biopsy. In this way, the in-vivo tissue sampling device (the part entering the body) becomes very small, and its outer diameter is even not greater than 1.0 mm, resulting in the requirement for the sampling assembly located at the head of the in-vivo tissue sampling device to be miniaturized, and its outer diameter is even less than 1.0 mm. Referring to Figure 1 , the sampling assembly 3 and the spring tube 21 (including the push-pull cable 22 inside the spring tube 21) are the parts entering the body, that is: they are required to be able to pass through small lumens such as the bronchi, so the sampling assembly 3, the spring tube 21, and the push-pull cable 22 inside the spring tube 21 are required to be very small, and their outer diameters are even required not to be greater than 1.0 mm. It is relatively easy to miniaturize the spring tube 21 and the push-pull cable 22 inside it, while the miniaturization of the sampling assembly 3 has always been a difficult point in the improvement of in-vivo tissue sampling devices. Especially, the miniaturized in-vivo tissue sampling device must also have reliability to ensure that the biopsy tissue can be cut off smoothly and removed from the human body.

[0003] In order to solve the problems of miniaturization and refinement of the sampling assembly of existing in-vivo tissue sampling devices, many miniaturization technical measures have been adopted. However, due to its unreasonable structure and the original defects of the component structures, its structure is relatively complex, which not only makes its assembly cumbersome and difficult, but also affects its reliability. To facilitate the analysis of the problems of the existing technology, first introduce the structure of the sampling assembly of the existing in-vivo tissue sampling device: Referring to Figure 2 ( Figure 2(Cross-sectional view of the prior art structure of the sampling component of the in-vivo tissue sampling device), the sampling component includes a pair of forceps head handles 32, a forceps head 3 composed of a pair of forceps jaws 31 provided on the forceps head handles 32, a forceps head seat 33 and a push-pull rod 36. The main body of the forceps head seat 33 is a sleeve. At one end of the sleeve, a pair of facing fins 331 are provided. A forceps head rotating shaft 34 is provided between the pair of fins 331, and both ends of the forceps head rotating shaft 34 are fixed to the pair of fins 331 respectively. The pair of forceps head handles 32 are arranged between the pair of facing fins 331 and sleeved on the forceps head rotating shaft 34, so that the pair of forceps head handles 32 are respectively rotatably connected to the forceps head rotating shaft 34. A gasket 4 is provided on the forceps head rotating shaft 34, and the gasket 4 is located between the forceps head handle 32 and the fin 331. A central shaft 5 is rotatably connected to the end of the forceps head handle 32. A (sheet-shaped) connecting member 35 is provided on the central shaft 5, and the central shaft 5 is fixedly connected to one end of the connecting member 35. A terminal rotating shaft 37 is fixed to the head of the push-pull rod 36, and the terminal rotating shaft 37 is rotatably connected to the other end of the connecting member 35.

[0004] Referring to Figure 1 (Schematic diagram of the structure of the in-vivo tissue sampling device), after connecting the outer sleeve spring tube 21 to the forceps head seat 33 and connecting the pull cable 22 of the outer sleeve spring tube 21 to the end of the push-pull rod 36, by pushing the pull cable 22 forward and pulling the pull cable 22 backward, the opening and closing of the forceps jaws 31 can be realized to complete the biopsy.

[0005] Although the in-vivo tissue sampling device and its sampling component in the prior art can be used for biopsy and sampling, such a mechanism still has the following defects: 1. The structural design of the sampling component is unreasonable, resulting in a complex structure and making the assembly or installation of the sampling component cumbersome and complex. As described above, in the prior art, a central shaft 5 is rotatably connected to the end of the forceps head handle 32. A (sheet-shaped) connecting member 35 is provided on the central shaft 5 and the central shaft 5 is fixedly connected to one end of the connecting member 35. Referring to Figure 2 , when implementing this structure, holes need to be drilled at the end of the forceps head handle 32 and one end of the connecting member 35 respectively, and then the central shaft 5 is inserted into these two holes. However, if the central shaft 5 is only inserted into these two holes, during the rotation and movement of the forceps head and the connecting member 35, the central shaft 5 will fall off and will probably remain in the patient's body, resulting in a medical accident. To solve this problem, the central shaft 5 uses a pin with a flange. The pin with a flange is inserted into the hole at the end of the forceps head handle 32 and the hole at one end of the connecting member 35 in sequence from the inside of the forceps head handle 32 and the outside of the connecting member 35 is fixed to the pin with a flange by welding. Although this problem is solved, a new problem appears, that is, the forceps jaws 31 will swing and shake: Referring to Figure 4, due to the existence of the connecting member 35 at the outer end of the jaw handle 32 and the welding point protrusion 351 of the central axis 5 and the connecting member 35, the outer side of the jaw handle 32 and the outer side of the connecting member 35 cannot be touched or fitted to the inner side of the wing 331, resulting in a gap A between the outer side of the jaw handle 32 and the inner side of the wing 331. When clamping or cutting the sampled tissue, the jaws 31 are stressed and swing and shake ( Figure 4 as shown by the KK arrow) and the two jaws 31 are misaligned with each other, causing the sampling to fail and having to replace the in-vivo tissue sampling device. To solve this new problem, that is, to eliminate the gap A, referring to Figure 2 , a gasket 4 is added between the outer side of the jaw handle 32 and the inner side of the wing 331. Thus, it can be seen that the connection structure of the end of the jaw handle 32 and the connecting member 35 is relatively complex and the number of components is large. Moreover, the new problem that appears in the connection structure of the end of the jaw handle 32 and the connecting member 35 has to add a new component, that is, the gasket 4, which makes the existing sampling assembly structure more complex and the number of components more, and its volume is relatively large as a result, and it is impossible to make an in-vivo tissue sampling device with an outer diameter of 1.0 mm. In addition, because the components of the sampling assembly are small and numerous, it also leads to difficult and complicated assembly or fitting.

[0006] 2. The complex structure of the sampling assembly restricts the further miniaturization and refinement of the sampling assembly of the in-vivo tissue sampling device and the in-vivo tissue sampling device. Since the existing technology requires that pairs of jaw handles 32, connecting members 35, flanges of the central axis 5 and welding point protrusions 351 must be accommodated between the wings, so many components make the sampling assembly relatively thick and large, restricting the further miniaturization of the in-vivo tissue sampling device. The present invention realizes the further miniaturization of the in-vivo tissue sampling device by means of simplifying the structure and reducing the number of components.

[0007] In summary, the existing in-vivo tissue sampling device or sampling assembly has technical defects such as cumbersome and difficult assembly and its further miniaturization being restricted by its own structure. Summary of the Invention

[0008] Aiming at the technical defects of the existing technology, such as cumbersome and difficult assembly, difficult further miniaturization and low reliability, the technical problem to be solved by the present invention is to provide an in-vivo tissue sampling device and its sampling assembly, and by improving the structure of its components, the assembly is simplified, the reliability of the in-vivo tissue sampling device and the sampling assembly is improved, and it has the advantage of being refinable.

[0009] The present invention adopts the following technical solutions to solve the above technical problems, that is: The present invention provides an in-vivo tissue sampling device, comprising: a handle, an outer sleeve, a push-pull cable disposed inside the outer sleeve, and a sampling assembly. The handle includes a handle body connected to one end of the outer sleeve and a slider slidably connected to the handle body. The slider is connected to one end of the push-pull cable. The sampling assembly includes a pair of jaw handles and a pair of jaws provided on the jaw handles, a jaw seat, and a push rod. The jaw seat is disposed at the other end of the outer sleeve and has a pair of facing fins. One end of the push rod is connected to the other end of the push-pull cable. A concave notch is respectively provided on the outer side of the end of each jaw handle, and a cylindrical protrusion is provided on the concave notch. The height h of the cylindrical protrusion is not greater than the depth d of the concave notch. The sum of the thicknesses of the two jaw handles is equal to the distance between the two fins. A terminal rotating shaft is provided at the other end of the push rod, and both ends of the terminal rotating shaft protrude from the push rod respectively. The thickness of the other end of the push rod in the axial direction of the terminal rotating shaft and the sum of the thicknesses of the two connecting pieces are equal to the distance between the two fins. A connecting piece with a thickness δ equal to the depth d of the concave notch is provided between the other end of the push rod and the end of the jaw handle. Moreover, the connecting piece is located outside the jaw handle and the push rod. Axial holes are respectively provided at both ends of the connecting piece, and a rotating pair is formed with the jaw handle and the push rod through the cylindrical protrusion and the terminal rotating shaft respectively. The pair of jaw handles are arranged back to back with their concave notches facing outwards, and are embedded in the jaw seat after being assembled with the connecting piece and the push rod through the cylindrical protrusion and the terminal rotating shaft. The outer side surface w11 of the jaw handle and the outer side surface w21 of the connecting piece are attached to the inner surface of the fin of the jaw seat. A jaw rotating shaft is fixed on the fin, and the jaw rotating shaft passes through the upper part of the back-to-back jaw handles and forms a rotating pair with the jaw handles and the fins.

[0010] The present invention also provides a sampling assembly of an in-vivo tissue sampling device, comprising a pair of jaw handles and a pair of jaws provided on the jaw handles, a jaw seat, and a push rod. The jaw seat has a pair of facing fins. A concave notch is respectively provided on the outer side of the end of each jaw handle, and a cylindrical protrusion is provided on the concave notch. The height h of the cylindrical protrusion is not greater than the depth d of the concave notch. The sum of the thicknesses of the two jaw handles is equal to the distance between the two fins. A terminal rotating shaft is provided at the other end of the push rod, and both ends of the terminal rotating shaft protrude from the push rod respectively. The thickness of the other end of the push rod in the axial direction of the terminal rotating shaft and the sum of the thicknesses of the two connecting pieces are equal to the distance between the two fins. A connecting piece with a thickness δ equal to the depth d of the concave notch is provided between the other end of the push rod and the end of the jaw handle. Moreover, the connecting piece is located outside the jaw handle and the push rod. Axial holes are respectively provided at both ends of the connecting piece, and a rotating pair is formed with the jaw handle and the push rod through the cylindrical protrusion and the terminal rotating shaft respectively. The pair of pliers head handles are arranged back to back with their recessed notches facing outward, and are integrally embedded in the pliers head seat after being assembled with the connecting piece and the push-pull rod through cylindrical protrusions and end rotating shafts. The outer side surface w11 of the pliers head handle and the outer side surface w21 of the connecting piece are attached to the inner surface of the wing of the pliers head seat. A pliers head rotating shaft is fixed on the wing. The pliers head rotating shaft passes through the upper part of the back-to-back pliers head handles and forms a rotating pair with the pliers head handles and the wing.

[0011] Compared with the prior art, the present invention has the following beneficial effects: Aiming at the defects of the prior art, such as a large number of components, complex structure, resulting in a complex and cumbersome assembly process, and difficulty in miniaturization, the present invention improves the sampling assembly to make it more miniaturized. Its outer diameter can be as small as 1.0 mm, with higher reliability, and the assembly process is simple and convenient for assembly.

[0012] (1) By improving the pliers head structure, the present invention makes the pliers head handle 32 and the connecting piece 35 in the sampling assembly both fit with the wing 331 of the pliers head seat, eliminating the gap between the pliers head handle 32, the connecting piece 35 and the wing 331 of the pliers head seat in the prior art. Finally, the in-vivo tissue sampling device becomes more miniaturized due to the improvement of the pliers head structure. As mentioned above, in the sampling assembly of the prior in-vivo tissue sampling device, the rotational connection between the pliers head handle 32 and the connecting piece 35 is realized through the central axis 5 passing through the pliers head handle 32 and the connecting piece 35. To prevent the central axis 5 from falling off due to its axial movement, a flange limit must be provided at the inner end of the central axis 5, and the outer end is fixed to the connecting piece 35 by welding. The solder pad located between the connecting piece 35 and the wing 331 of the pliers head seat causes the generation of the gap therebetween, so that neither the pliers head handle 32 nor the connecting piece 35 can fit with the wing 331 of the pliers head seat. Therefore, this gap is the reason for the relatively large size of the in-vivo tissue sampling device. Aiming at this defect, the present invention improves the existing pliers head structure. First, a recessed notch 322 is dug at the end of the pliers head handle 32. The recessed notch 322 is used to just accommodate the sheet-shaped connecting piece 35, that is, the depth of the recessed notch 322 is equal to the thickness of the sheet-shaped connecting piece 35. A cylindrical protrusion 321 is fixedly connected in the recessed notch 322. There is a matching hole on the connecting piece 35. When the connecting piece 35 is sleeved on the cylindrical protrusion 321, the outer side surface of the recessed notch 322 and the outer side surface of the connecting piece 35 are coplanar, that is, the two are in the same plane, so that the outer side surface of the recessed notch 322 and the outer side surface of the connecting piece 35 can directly fit with the inner surface of the wing 331 of the pliers head seat, eliminating the gap between the outer side surface of the recessed notch 322 and the outer side surface of the connecting piece 35 and the inner surface of the wing 331 of the pliers head seat. Therefore, the present invention eliminates the gap in the prior art through structural improvement, that is, eliminates the gap that causes the in-vivo tissue sampling device to be thick and large, making the present invention more miniaturized.

[0013] (2) By improving the structure of the pliers head, the assembly process of the present invention is made simple and the difficulty is reduced. As described above, the present invention has improved the pliers head handle 32 in the sampling assembly, that is: ① A concave notch 322 is provided, and a cylindrical protrusion 321 serving as a rotating shaft is fixed in the concave notch 322. A sheet-like connecting member 35 with a thickness value equal to the depth of the concave notch 322 is selected. When the connecting member 35 is sleeved on the cylindrical protrusion 321, the outer side surface of the connecting member 35, the outer side surface of the pliers head handle 32, and the end surface of the cylindrical protrusion 321 are all in the same plane. It should be noted here that the connecting member 35 and the cylindrical protrusion 321 do not need to be welded or fixed, but only sleeved on the cylindrical protrusion 321, and the two can rotate relative to each other; ② The thickness of the head of the push-pull rod 36 (i.e., the other end of the push-pull rod 36) and the sum of the thicknesses of the two connecting members 35 are equal to the distance between the two wing pieces 331. The end rotating shaft 37 is inserted into the head of the push-pull rod 36 and the two connecting members 35 located on both sides thereof. The end rotating shaft 37 is not fixed to the connecting member 35, and the connecting member 35 is only sleeved on the end rotating shaft 37; the sum of the thicknesses of the two pliers head handles 32 is equal to the distance between the two wing pieces 331. Based on these improvements, when the pliers head handle 32 (pliers head), the connecting member 35, and the push-pull rod 36 are assembled through the cylindrical protrusion 321 and the end rotating shaft 37 and then inserted as a whole between the two wing pieces 331, the pliers head handle 32 (pliers head), the connecting member 35, and the push-pull rod 36 are all clamped between the wing pieces by the cylindrical protrusion 321 and the end rotating shaft 37. Finally, the pliers head rotating shaft 34 is inserted into the two wing pieces 331 and the pliers head handle 32 and the pliers head rotating shaft 34 is fixed to the wing piece 331, thus assembling a complete sampling assembly.

[0014] The above structural improvement of the present invention eliminates the welding step of the central shaft 5 and the upsetting steps at both ends of the end rotating shaft 37 that are necessary and indispensable in the prior art, making its assembly process simpler and less difficult compared to the assembly process of the existing in-vivo tissue sampling device, and improving the production efficiency, as follows: ①Compared with the prior art, the present invention omits the welding step of the central axis 5. In the prior art, the pliers head handle 32 is rotatably connected to the connecting member 35 through the central axis 5. To ensure that the central axis 5 does not axially move or fall off, limiting measures need to be taken. A necessary limiting measure in the prior art is to weld the outer sides of the central axis 5 and the connecting member 35. Therefore, the welding step in the assembly process of the prior in-vivo tissue sampling device is caused by the fixed connection between the central axis 5 and the connecting member 35 required by its structure. In contrast, in the present invention, the connecting member 35 only needs to be sleeved on the cylindrical protrusion 321, and it is not necessary and cannot weld the cylindrical protrusion 321 and the connecting member 35. On the one hand, the cylindrical protrusion 321 is fixed to the pliers head handle 32, and the cylindrical protrusion 321 and the pliers head handle 32 can be directly processed into a whole. On the other hand, the connecting member 35 is in contact with the wing piece, and the limiting effect of the wing piece on the connecting member 35 ensures that the connecting member 35 is always sleeved on the cylindrical protrusion 321 and does not come off. Moreover, it is necessary to ensure that the connecting member 35 can rotate on the cylindrical protrusion 321. Therefore, the improved structure adopted by the present invention omits the welding step between the connecting member and the shaft that is necessary in the prior art.

[0015] ②Compared with the prior art, the present invention omits the upsetting steps at both ends of the end rotating shaft 37. In the prior art, the connecting member 35 is rotatably connected to the wing piece through the end rotating shaft 37. Since there is a gap between the connecting member 35 and the wing piece in this structure, to prevent the wing piece from detaching from the end rotating shaft 37, the end of the end rotating shaft 37 is upset to limit the connecting member 35. Therefore, the step of upsetting the end of the end rotating shaft 37 is an essential step in its assembly process. In contrast, the improved structure of the present invention eliminates the gap between the connecting member 35 and the wing piece. The connecting member 35 is directly in contact with the wing piece, and the wing piece limits the connecting member 35 and the end rotating shaft 37. Therefore, the improved structure changes the limiting method. The connecting member 35 only needs to be sleeved on the end rotating shaft 37 and inserted between the two wing pieces. Therefore, the improved structure adopted by the present invention omits the upsetting step at the end of the end rotating shaft 37 that is necessary in the prior art.

[0016] Since the in-vivo tissue sampling device is very small, with an outer diameter of only 2.3 mm, 1.8 mm or even 1.0 mm, each additional process will bring great trouble and increase the difficulty of assembly. The present invention omits the essential welding step and upsetting step in the assembly process of the prior in-vivo tissue sampling device, thus simplifying the assembly process and reducing the difficulty.

[0017] (3) By improving the structure of the pliers head, the reliability of the present invention is enhanced. As described above, the pliers head handle 32 (pliers head), the connecting member 35, and the push-pull rod 36 are integrally inserted between the two wing pieces 331 after being assembled through the cylindrical protrusion 321 and the end rotating shaft 37. The pliers head handle 32 (pliers head), the connecting member 35, and the push-pull rod 36 are all clamped between the wing pieces by the cylindrical protrusion 321 and the end rotating shaft 37, and their outer surfaces are all in contact with the inner surfaces of the wing pieces. When the push-pull cable 22 drives the connecting member 35 to rotate, thereby driving the pliers head to open and close, the inner surface of the wing piece guides the connecting member 35, causing the connecting member 35 to always rotate in the original plane, that is, the inner surface of the wing piece, ultimately ensuring that the two jaws 31 of the in-vivo tissue sampling device are always aligned and do not shift during the tissue sampling (cutting and sampling tissue) process. Therefore, the improved pliers head structure endows the present invention with the advantage of high reliability. Description of the Drawings

[0018] Figure 1 It is a schematic structural diagram of the in-vivo tissue sampling device.

[0019] Figure 2 It is a cross-sectional view of the prior art structure of the sampling assembly.

[0020] Figure 3 It is a structural diagram of the prior art pliers head part, where Figure 3 a is the front view of the pliers head, Figure 3 b is the left view of the pliers head. Figure 4 It is a reference diagram of the partial structure of the sampling assembly.

[0021] Figure 5 It is a schematic diagram of the mechanism of the sampling assembly of the present invention, where Figure 5 a is the front view of the sampling assembly, Figure 5 b is the left view of the sampling assembly, Figure 5 c is the combined cross-sectional view B-B of the sampling assembly.

[0022] Figure 6 It is a structural diagram of the pliers head part of the present invention, where Figure 6 a is the front view of the pliers head, Figure 6 b is the left view of the pliers head.

[0023] Figure 7 It is a schematic diagram of the partial improved structure of the sampling assembly of the present invention and the prior art.

[0024] Figure 8 It is an exploded view of the sampling assembly of the present invention.

[0025] Wherein, 1: handle, 11: slider, 12: handle body; 21: spring tube, 22: push-pull cable; 3: sampling assembly, 31: jaws, 32: jaw handle, 321: cylindrical protrusion, h: height of the cylindrical protrusion 321, 322: recessed notch, d: depth of the recessed notch 322, w11: outer side surface of the jaw handle 32, 33: jaw seat, 331: fin, 34: jaw rotating shaft, 35: connecting piece, δ: thickness of the connecting piece 35, w21: outer side surface of the connecting piece 35, 36: push rod, 37: end rotating shaft; 4: gasket; 5: central shaft. Detailed implementation mode Embodiment 1

[0026] An in-vivo tissue sampling device includes: a handle 1, an outer sleeve, a push-pull cable 22 disposed inside the outer sleeve, and a sampling assembly 3. The handle 1 includes a handle body 12 connected to one end of the outer sleeve and a slider 11 slidably connected to the handle body 12. The slider 11 is connected to one end of the push-pull cable 22. The sampling assembly 3 includes a jaw formed by a pair of jaw handles 32 and jaws 31 disposed on the jaw handles 32, a jaw seat 33, and a push rod 36. The jaw seat 33 is disposed at the other end of the outer sleeve and has a pair of facing fins 331. One end of the push rod 36 is connected to the other end of the push-pull cable 22. A recessed notch 322 is respectively provided on the outer side of the end of each jaw handle 32, and a cylindrical protrusion 321 is provided on the recessed notch 322. The height h of the cylindrical protrusion 321 is not greater than the depth d of the recessed notch 322. The sum of the thicknesses of the two jaw handles 32 is equal to the distance between the two fins 331. An end rotating shaft 37 is provided at the other end of the push rod 36, and both ends of the end rotating shaft 37 respectively protrude from the push rod 36. The thickness of the other end of the push rod 36 in the axial direction of the end rotating shaft 37 and the sum of the thicknesses of the two connecting pieces 35 are equal to the distance between the two fins 331. A connecting piece 35 with a thickness δ equal to the depth d of the recessed notch 322 is provided between the other end of the push rod 36 and the end of the jaw handle 32. Moreover, the connecting piece 35 is located on the outer sides of the jaw handle 32 and the push rod 36. Axial holes are respectively provided at both ends of the connecting piece 35, and a rotating pair is respectively formed with the jaw handle 32 and the push rod 36 through the cylindrical protrusion 321 and the end rotating shaft 37. The pair of jaw handles 32 are arranged back to back with their recessed notches 322 facing outward, and are assembled with the connecting piece 35 and the push rod 36 through the cylindrical protrusion 321 and the end rotating shaft 37 and then embedded in the jaw seat 33. The outer side surface w11 of the jaw handle 32 and the outer side surface w21 of the connecting piece 35 are attached to the inner surface of the fin 331 of the jaw seat 33. A jaw rotating shaft 34 is fixed on the fin 331. The jaw rotating shaft 34 passes through the upper part of the back-to-back jaw handles 32 and forms a rotating pair with the jaw handles 32 and the fin 331.

[0027] In this embodiment: The outer sleeve is a bellows 21; the push-pull cable 22 is a bendable and resilient steel wire. During tissue sampling, by pushing forward the handle body 12 and utilizing the bending and resilient characteristics of the push-pull cable 22, the in-vivo tissue sampling device can move in the lumen of the main bronchus, bronchus, etc. By pulling back the handle body 12, the in-vivo tissue sampling device can smoothly withdraw; the cylindrical protrusion 321 is formed by bulging outward from the concave notch 322, that is: refer to Figure 6 , the cylindrical protrusion 321 and the clamp head handle 32 are an integral part and form a single component. Or, the cylindrical protrusion 321 is a cylindrical pin, and the cylindrical pin is threadedly connected to the concave notch 322, that is: the end of the cylindrical protrusion 321 is provided with an external thread, a threaded hole is opened on the concave notch 322, and the cylindrical protrusion 321 is screwed into the threaded hole on the concave notch 322 so that the cylindrical protrusion 321 is fixed on the concave notch 322. Embodiment 2

[0028] Refer to Figure 5 and Figure 8 , a sampling assembly of an in-vivo tissue sampling device, including a clamp head composed of a pair of clamp head handles 32 and a clamp mouth 31 provided on the clamp head handles 32, a clamp head seat 33, and a push-pull rod 36. The clamp head seat 33 has a pair of facing fins 331, A concave notch 322 is respectively provided on the outer side of the end of each clamp head handle 32, and a cylindrical protrusion 321 is provided on the concave notch 322. The height h of the cylindrical protrusion 321 is not greater than the depth d of the concave notch 322, and the sum of the thicknesses of the two clamp head handles 32 is equal to the distance between the two fins 331; A terminal rotating shaft 37 is provided at the other end of the push-pull rod 36, and both ends of the terminal rotating shaft 37 protrude from the push-pull rod 36 respectively. The thickness of the other end of the push-pull rod 36 in the axial direction of the terminal rotating shaft 37 and the sum of the thicknesses of the two connecting pieces 35 are equal to the distance between the two fins 331; A connecting piece 35 with a thickness δ equal to the depth d of the concave notch 322 is provided between the other end of the push-pull rod 36 and the end of the clamp head handle 32. And the connecting piece 35 is located on the outer sides of the clamp head handle 32 and the push-pull rod 36. Axial holes are respectively provided at both ends of the connecting piece 35, and a rotational pair is formed with the clamp head handle 32 and the push-pull rod 36 through the cylindrical protrusion 321 and the terminal rotating shaft 37 respectively; The pair of pliers handle 32 are arranged back to back, with their recessed notches 322 facing outward, and are integrally embedded in the pliers head seat 33 after being assembled with the connecting member 35 and the push-pull rod 36 through the cylindrical protrusion 321 and the end rotating shaft 37. The outer side surface w11 of the pliers handle 32 and the outer side surface w21 of the connecting member 35 are attached to the inner surface of the fin 331 of the pliers head seat 33. A pliers head rotating shaft 34 is fixed to the fin 331. The pliers head rotating shaft 34 passes through the upper part of the back-to-back pliers handles 32 and forms a rotating pair with the pliers handles 32 and the fin 331.

[0029] In this embodiment, the cylindrical protrusion 321 can be formed by bulging outward from the recessed notch 322, or the cylindrical protrusion 321 can be a cylindrical pin, and the cylindrical pin is threadedly connected to the recessed notch 322.

[0030] The following makes a more detailed description of the specific implementation manners of the present invention with reference to the accompanying drawings: Referring to Figure 1 , the handle 1 of the present invention can adopt the handle technical solution of the prior art. The handle 1 includes a handle body 12 and a slider 11. The slider 11 is sleeved on the handle body 12 to enable the slider 11 to slide on the handle body 12.

[0031] Referring to Figure 5 and Figure 1 , the outer sleeve tube adopts a spring tube 21. The push-pull cable 22 disposed inside the spring tube 21 can adopt a bendable and resilient steel wire. One end of the spring tube 21 is connected to the handle body 12, and the other end thereof is connected to the pliers head seat 33 in the sampling assembly 3. The bendable and resilient steel wire can be pulled or slid back and forth inside the spring tube 21. One end thereof is connected to the slider 11 of the handle 1, and the other end thereof is connected to one end of the push-pull rod 36 in the sampling assembly 3.

[0032] Referring to Figure 5 , Figure 6 and Figure 8 , the present invention first improves the pliers head, and the improvement point lies in: the combined structure formed by the recessed notch 322 of the pliers handle 32, the cylindrical protrusion 321 thereon, the connecting member 35, the fin 331 of the pliers head seat 33 and their connection relationship and positional relationship. Figure 6 is the pliers head structure. The pliers head includes a pair of pliers handles 32 and a pliers mouth 31 provided on the pliers handles 32. The pliers handles 32 and the pliers mouth 31 can be integrally formed. The present invention first improves the pliers handles 32, that is: a recessed notch 322 is respectively provided on the outer sides of the ends of the pliers handles 32, a cylindrical protrusion 321 is provided on the recessed notch 322, and the cylindrical protrusion 321 is fixed on the recessed notch 322. The height h of the cylindrical protrusion 321 is not greater than the depth d of the recessed notch 322. As an embodiment, Figure 6 the example shown is where the height h of the cylindrical protrusion 321 is equal to the depth d of the recessed notch 322; secondly, referring toFigure 7 , in the present invention, a connecting member 35 with a thickness δ equal to the recessed depth d of the recessed notch 322 is adopted. When the connecting member 35 is assembled or sleeved on the cylindrical protrusion 321, the inner side of the connecting member 35 fits against the recessed notch 322, and the outer surface of the connecting member 35 is coplanar with the outer surface of the pliers head handle 32, that is, located in the same plane. Then, the head thickness of the push-pull rod 36 is selected as the difference between the distance between the inner sides of the two wing pieces 331 and twice the thickness δ of the connecting member 35, so that the assembled combination of the pliers head handle 32, the connecting member 35, the end rotating shaft 37 and the push-pull rod 36 can be integrally attached to the inner surface of the wing piece 331 without any gap therebetween, eliminating the gasket for eliminating the gap therebetween which is indispensable in the prior art. With the reduction of components, the structure of the present invention is simplified, the structure is relatively simpler, and a tissue sampling device with an outer diameter of 1 mm can be manufactured. In addition, its assembly becomes simple, that is, the assembly process is simplified, and the overall limit and positioning provided by a pair of wing pieces 331 for the combination are more reliable.

[0033] In the present invention, the outer side of the end of the pliers head handle 32 or the outer side of the pliers head handle 32 refers to the side of the end of the pliers head handle 32 facing the wing piece 331 or one side of the pliers head handle 32, and the side opposite to the wing piece 331 is its inner side; the outer side of the connecting member 35 refers to the side of the connecting member 35 facing the wing piece 331, and the inner side of the connecting member 35 refers to the side of the connecting member 35 opposite to the wing piece 331; the inner side of the wing piece 331 refers to the side of the wing piece facing the pliers head handle 32 or the connecting member 35.

[0034] During use, referring to Figure 1 and Figure 5 , push and pull the slider 11, and the slider 11 can slide back and forth on the handle body 12. Then, drive the push-pull rod 36 of the sampling assembly 3 to slide back and forth in the pliers head seat 33 through the push-pull cable 22 connected to the slider 11, and the jaws 31 of the pliers head open and close accordingly to achieve tissue sampling.

Claims

1. An in-vivo tissue sampling device, comprising: A handle (1), an outer sleeve, a push-pull cable (22) disposed inside the outer sleeve, and a sampling assembly (3). The handle (1) includes a handle body (12) connected to one end of the outer sleeve and a slider (11) slidably connected to the handle body (12). The slider (11) is connected to one end of the push-pull cable (22). The sampling assembly (3) includes a pair of pliers head handles (32) and a pliers head (31) disposed on the pliers head handles (32), a pliers head seat (33), and a push-pull rod (36). The pliers head seat (33) is disposed at the other end of the outer sleeve and has a pair of facing fins (331). One end of the push-pull rod (36) is connected to the other end of the push-pull cable (22). It is characterized in that, A concave notch (322) is respectively provided on the outer side of the end of each pliers head handle (32), and a cylindrical protrusion (321) is provided on the concave notch (322). The height h of the cylindrical protrusion (321) is not greater than the depth d of the concave notch (322). The sum of the thicknesses of the two pliers head handles (32) is equal to the distance between the two fins (331); A terminal rotating shaft (37) is provided at the other end of the push-pull rod (36), and both ends of the terminal rotating shaft (37) respectively protrude from the push-pull rod (36). The thickness of the other end of the push-pull rod (36) in the axial direction of the terminal rotating shaft (37) and the sum of the thicknesses of the two connecting members (35) are equal to the distance between the two fins (331); A connecting member (35) with a thickness δ equal to the depth d of the concave notch (322) is provided between the other end of the push-pull rod (36) and the end of the pliers head handle (32). And the connecting member (35) is located outside the pliers head handle (32) and the push-pull rod (36). Axial holes are respectively provided at both ends of the connecting member (35), and a rotational pair is respectively formed with the pliers head handle (32) and the push-pull rod (36) through the cylindrical protrusion (321) and the terminal rotating shaft (37); The pair of pliers head handles (32) are arranged back to back with their concave notches (322) facing outward, and are assembled with the connecting member (35) and the push-pull rod (36) through the cylindrical protrusion (321) and the terminal rotating shaft (37) and then embedded in the pliers head seat (33). The outer side surface w11 of the pliers head handle (32) and the outer side surface w21 of the connecting member (35) are attached to the inner surface of the fins (331) of the pliers head seat (33). A pliers head rotating shaft (34) is fixed on the fins (331). The pliers head rotating shaft (34) passes through the upper part of the back-to-back pliers head handles (32) and forms a rotational pair with the pliers head handle (32) and the fins (331).

2. The in-vivo tissue sampling device according to claim 1, wherein The outer sleeve is a spring tube (21).

3. The in vivo tissue sampling device according to claim 1, characterized in that, The push-pull cable (22) is a bendable and resilient steel wire.

4. The in-vivo tissue sampling device according to claim 1, 2 or 3, characterized in that, The cylindrical protrusion (321) is formed by bulging outward from the concave notch (322).

5. The in-vivo tissue sampling device according to claim 1, 2 or 3, characterized in that, The cylindrical protrusion (321) is a cylindrical pin, and the cylindrical pin is threadedly connected to the concave notch (322).

6. The sampling assembly of an in-vivo tissue sampling device, comprising a pair of forceps heads composed of a pair of forceps head handles (32) and forceps jaws (31) provided on the forceps head handles (32), a forceps head seat (33) and a push-pull rod (36), wherein the forceps head seat (33) has a pair of facing fins (331), and is characterized in that a recessed notch (322) is respectively provided on the outer side of the end of each forceps head handle (32), a cylindrical protrusion (321) is provided on the recessed notch (322), the height h of the cylindrical protrusion (321) is not greater than the depth d of the recessed notch (322), and the sum of the thicknesses of the two forceps head handles (32) is equal to the distance between the two fins (331); a terminal rotating shaft (37) is provided at the other end of the push-pull rod (36), and both ends of the terminal rotating shaft (37) respectively protrude from the push-pull rod (36), and the thickness of the other end of the push-pull rod (36) in the axial direction of the terminal rotating shaft (37) and the sum of the thicknesses of the two connecting pieces (35) are equal to the distance between the two fins (331); a connecting piece (35) with a thickness δ equal to the depth d of the recessed notch (322) is provided between the other end of the push-pull rod (36) and the end of the forceps head handle (32), and the connecting piece (35) is located on the outer sides of the forceps head handle (32) and the push-pull rod (36). Axial holes are respectively provided at both ends of the connecting piece (35), and a rotating pair is respectively formed with the forceps head handle (32) and the push-pull rod (36) through the cylindrical protrusion (321) and the terminal rotating shaft (37); the pair of forceps head handles (32) are arranged back to back with their recessed notches (322) facing outward, and are integrally embedded in the forceps head seat (33) after being assembled with the connecting piece (35) and the push-pull rod (36) through the cylindrical protrusion (321) and the terminal rotating shaft (37). The outer side surface w11 of the forceps head handle (32) and the outer side surface w21 of the connecting piece (35) are attached to the inner surface of the fins (331) of the forceps head seat (33). A forceps head rotating shaft (34) is fixed on the fins (331), and the forceps head rotating shaft (34) passes through the upper part of the back-to-back forceps head handles 32) and forms a rotating pair with the forceps head handle (32) and the fins (331).

7. The sampling assembly of the in-vivo tissue sampling device according to claim 6, wherein, The cylindrical protrusion (321) is formed by bulging outward from the recessed notch (322).

8. The sampling assembly of the in-vivo tissue sampling device according to claim 6, wherein The cylindrical protrusion (321) is a cylindrical pin, and the cylindrical pin is threadedly connected to the recessed notch (322).

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