Multivitamin microcapsules, and methods of making and using the same

Abstract

The application discloses a kind of multi-vitamin microcapsules and preparation method and application thereof, belong to medical manufacturing industry and dietary nutrient supplement technical field.The plant raw material is selected, is extracted by immersion, alcohol precipitation, stirring, drying, and plant slime polysaccharide powder is obtained;Polyglycerol polyricinoleate is mixed with sunflower seed oil, and beta-carotene, vitamin D3 is added, stirring, and oil phase is obtained;Vitamin B1, vitamin B2, vitamin C is dissolved in water, and water phase is obtained;The plant slime polysaccharide powder is dissolved in water, and malt dextrin and gum arabic are added, and stirred uniformly, and wall material solution is obtained;Water phase is added to oil phase, shear, and wall material solution is mixed, shear, high-pressure homogenization, by emulsification and homogenization, and homogeneous liquid material is obtained;After spray drying, multi-vitamin microcapsules are obtained.The multi-vitamin microcapsules have high encapsulation efficiency and good structural stability, and can significantly improve the stability of vitamins.

Description

Technical Field

[0001] This invention relates to the fields of pharmaceutical manufacturing and dietary supplement technology, and particularly to a multivitamin microcapsule, its preparation method, and its application. Background Technology

[0002] Multivitamins, also known as multivitamins or multivitamin tablets, are nutritional supplements containing a variety of vitamins and minerals. They can be used as an adjunct supplement for nutrient deficiencies caused by unbalanced diets, poor digestion and absorption, or other reasons. Multivitamins typically include vitamins A, C, D, E, B vitamins (including B1, B2, B6, B12, etc.), folic acid, calcium, iron, zinc, and magnesium. Vitamins are essential micronutrients for the human body, playing a crucial role in various biochemical reactions. However, the natural content of vitamins is low, and they are easily affected by external factors such as oxidation, heat treatment, and light exposure during production, storage, and processing, leading to a decline in their biological activity.

[0003] Microcapsules are miniature containers with polymer or inorganic walls. Existing protein microcapsules are sensitive to high temperatures, which can lead to denaturation, structural damage, and core material leakage, and they are also costly. Gum-based microcapsules, such as those made of gum arabic or gelatin, suffer from high price, low purity, and limited availability. Synthetic polymer microcapsules are prone to environmental pollution and biocompatibility issues. Other types, such as nanoscale microcapsules, are susceptible to adhesion problems and breakage risks. Therefore, improving the selection of wall materials and preparation processes to enhance encapsulation efficiency and structural integrity is a critical technical challenge that needs to be addressed in current technologies. Summary of the Invention

[0004] Based on the technical problems to be solved by the present invention, the present invention proposes a multivitamin microcapsule, its preparation method and application. The multivitamin microcapsule is prepared by using a microcapsule preparation method based on plant mucilage polysaccharides, so as to improve the encapsulation rate and structural stability of vitamins and expand the application of vitamins in food.

[0005] One objective of this invention is to provide a method for preparing multivitamin microcapsules, comprising the following steps:

[0006] S1. Select cactus, okra or aloe vera, peel or remove seeds, extract, precipitate with alcohol, stir to obtain gel, collect gel, dry to obtain plant mucilage polysaccharide powder;

[0007] S2. Mix polyglycerol polyricinoleate (PGPR) with sunflower seed oil, heat to 55℃~75℃, stir, cool, add β-carotene and / or vitamin D3, stir, and obtain the oil phase;

[0008] S3. Dissolve vitamin B1, vitamin B2, and / or vitamin C in water to obtain an aqueous phase;

[0009] S4. Dissolve the plant mucilage polysaccharide powder in water, add maltodextrin (MD) and gum arabic (GA), stir evenly to obtain a wall material solution;

[0010] S5. Add the aqueous phase to the oil phase, shear, mix with the wall material solution, shear, and homogenize under high pressure. Through emulsification and homogenization, obtain the homogenized liquid material.

[0011] S6. Spray dry the homogenized liquid to obtain multivitamin microcapsules.

[0012] Furthermore, the cactus or aloe vera is peeled, and the okra is seeded.

[0013] The volume ratio of the cactus, okra, or aloe vera to the water is 1:1 to 1:4.

[0014] The water is distilled water;

[0015] The extraction time is 24 hours;

[0016] The alcohol precipitation is performed by adding more than 75% ethanol to precipitate a white milky gel precipitate; preferably, the ethanol concentration is more than 80%.

[0017] The drying temperature is 20℃~60℃; the drying time is 12h~36h.

[0018] Furthermore, the polyglycerol polyricinoleate has a mass concentration of 1% to 9%;

[0019] The stirring degree is sufficient for complete dissolution;

[0020] The polyglycerol polyricinoleate and sunflower seed oil were mixed under the following conditions: 45℃~85℃ for 10min~50min.

[0021] Further, the mucopolysaccharide has a mass-to-volume ratio of 0.01% to 0.09%; the maltodextrin or gum arabic has a mass-to-volume ratio of 2% to 10%.

[0022] Furthermore, the water-to-oil mass ratio of the multivitamin microcapsules is 1:9 to 5:5; and the core-to-wall mass ratio is 1:1 to 1:9.

[0023] Furthermore, after the aqueous phase and the oil phase are mixed, the shearing with the wall material solution is high-speed shearing; the high-speed shearing speed is 10000 r / min to 16000 r / min, and the processing time is 1 min to 10 min;

[0024] The aqueous phase, the oil phase, and the wall material solution after high-speed shearing are homogenized at a pressure of 100 bar to 500 bar for 1 min to 10 min.

[0025] Furthermore, the inlet air temperature of the spray dryer is 115℃~125℃, the outlet air temperature is 50℃~70℃, and the flow rate is 3mL / min~10mL / min.

[0026] Furthermore, the gel is a white emulsion; the gel is dried at 20℃~60℃ for 12h~36h.

[0027] The second objective of this invention is to provide a multivitamin microcapsule, prepared according to the method for preparing the multivitamin microcapsule.

[0028] A third objective of this invention is to provide an application of multivitamin microcapsules in the pharmaceutical, feed, or food industries.

[0029] Compared with existing technologies, this invention proposes a multivitamin microcapsule, its preparation method, and its application, which have the following beneficial effects:

[0030] 1. The multivitamin microcapsules proposed in this invention are based on plant mucilage polysaccharides, with raw materials selected from natural plants such as cactus, okra, and aloe vera. These materials offer advantages such as being natural, safe, odorless, preservative-free, and bactericide-free. Furthermore, plant mucilage polysaccharides possess stable chemical properties, making them resistant to chemical reactions or cross-linking with certain drugs. They can also encapsulate various types of core materials, including solids, liquids, and gases. The release rate of the core material can be precisely controlled, resulting in a good controlled-release effect. As a natural polymer material, plant mucilage polysaccharides are widely available and renewable, reducing reliance on traditional chemical materials and minimizing environmental pollution.

[0031] 2. The multivitamin microcapsules proposed in this invention explore the ratio of aqueous and oil phases in depth, overcoming the shortcomings of existing dual-emulsion system emulsifier wall materials, which have the disadvantages of rapid drying speed, difficulty in completely encapsulating vitamins, and uneven and incomplete microcapsule structures. The invention proposes a wall material based on plant mucilage polysaccharides, and further improves the encapsulation rate and microcapsule structural stability by optimizing the microcapsule preparation process.

[0032] 3. The multivitamin microcapsules prepared by this invention encapsulate vitamins in nano- or micron-sized capsules. Microencapsulation technology can effectively isolate vitamins from environmental factors that are detrimental to them, while masking unpleasant tastes and enabling controlled release. Attached Figure Description

[0033] Figure 1The yield diagram of multivitamin microcapsules with different wall material compositions according to an embodiment of the present invention is shown.

[0034] Figure 2 The diagram shows the water content of multivitamin microcapsules with different wall material compositions according to an embodiment of the present invention.

[0035] Figure 3 The diagram shows the microstructure of a multivitamin microcapsule with different wall material compositions according to an embodiment of the present invention. Detailed Implementation

[0036] Exemplary embodiments of the present application will now be described in more detail with reference to the accompanying drawings. While exemplary embodiments of the present application are shown in the drawings, it should be understood that the present application may be implemented in various forms and should not be limited to the embodiments set forth herein. Rather, these embodiments are provided so that this application will be thorough and complete, and will fully convey the scope of the present application to those skilled in the art.

[0037] Unless otherwise specified, the technical means used in the following embodiments are conventional means well known to those skilled in the art, and the reagents and materials in this invention are obtained from the market or other public channels.

[0038] The experimental materials and equipment involved in this invention mainly include, but are not limited to:

[0039] Reagents:

[0040] Maltodextrin (Yuanye Biotechnology), Sunflower Seed Oil (Yihai Kerry Golden Dragon Fish), Gum Arabic Powder (Sinopharm Chemical Reagent Co., Ltd.), L(+)-Ascorbic Acid (99.7% Sinopharm Chemical Reagent Co., Ltd.), Polyglycerol Ricinoleic Acid Ester (75% Shanghai Maclean Biochemical Technology Co., Ltd.), β-Carotene (96% Shanghai Maclean Biochemical Technology Co., Ltd.), Vitamin B1 (99% Kinglong Beijing Biotechnology Co., Ltd.), Vitamin D3 (97% Kinglong Beijing Biotechnology Co., Ltd.), Riboflavin (Kinglong Beijing Biotechnology Co., Ltd.);

[0041] instrument:

[0042] High-speed dispersion homogenizer (FJ200-SH, Shanghai Huxi Industrial Co., Ltd.), high-pressure homogenizer (APV-2000, Abeway Far East Equipment Co., Ltd.), small spray dryer (ADL 311, Yamato Technology Trading (Shanghai) Co., Ltd.), high-performance liquid chromatograph (Model 1100, Agilent Technologies, Inc.), scanning electron microscope (JEOL 7500F, Nippon Electron Ltd.).

[0043] This invention discloses a multivitamin microcapsule, its preparation method, and its application. Using plants such as cactus, okra, and aloe vera as raw materials, plant mucilage polysaccharides are prepared through steps including peeling or deseeding, extraction, alcohol precipitation, drying, and grinding. Subsequently, polyglycerol polyricinoleate is mixed with sunflower seed oil and heated to 65°C to dissolve. After cooling, β-carotene and vitamin D3 are added to form the oil phase. Simultaneously, vitamins B1, B2, and C are dissolved in distilled water to form the aqueous phase. Plant mucilage polysaccharide powder is dissolved in distilled water, and maltodextrin and gum arabic are added to form the wall material solution. The aqueous and oil phases are mixed in a specific ratio, subjected to high-speed shearing, then mixed with the wall material solution and homogenized under high pressure. Finally, multivitamin microcapsules are obtained by spray drying. The multivitamin microcapsules prepared by the method of this invention have high encapsulation efficiency and good structural stability, significantly improving the stability of vitamins and expanding their application in the food industry.

[0044] The main technical principles of this invention include:

[0045] By leveraging the synergistic effect of plant mucilage polysaccharides and PGPR, combined with the formation mechanism of a dual emulsion system, the limitations of traditional microencapsulation technology in terms of encapsulation efficiency, stability, and controlled release performance have been overcome. Plant mucilage polysaccharides possess a unique polymer chain structure, with polysaccharide chains linked by glycosidic bonds to form network or branched polymers. This structure endows them with excellent hydrophilicity and high hydration capacity, enabling them to form stable colloidal solutions in the aqueous phase, providing high viscosity and strong rheological properties for the microcapsule wall material. Through synergistic effects with excipients such as maltodextrin and gum arabic, plant mucilage polysaccharides further enhance the structural stability of the wall material through intermolecular interactions such as hydrogen bonds and van der Waals forces, effectively preventing the destruction of vitamins by the external environment and ensuring efficient encapsulation and controlled release of multivitamins. During the emulsification process, PGPR, as an amphoteric surfactant, plays a crucial role. Its molecules consist of hydrophilic polyglycerol chains and hydrophobic ricinoleic acid chains, exhibiting excellent emulsifying properties. In aqueous solution, PGPR self-assembles into micelles, forming a stable emulsion film at the oil-water interface, reducing interfacial tension and ensuring the stability of the oil-water phase. In microcapsule preparation, PGPR not only stabilizes the formation of the base emulsion but also plays a crucial role in the formation of biemulsion (O / W / O or W / O / W) structures. By precisely controlling the concentration of PGPR and emulsification conditions, the stability of the biemulsion structure is ensured, thereby achieving uniform encapsulation and controlled release of vitamins.

[0046] Based on the above principles, this invention proposes a multivitamin microcapsule, its preparation method, and its application, including:

[0047] S1. Wash the cactus, okra, and aloe vera with distilled water. Use a knife to separate the inner pulp of the cactus and aloe vera and slice them. At the same time, remove the seeds from the okra and slice it. Add the above-treated materials to distilled water at a volume ratio of 1:2 and let stand for 24 hours. Then filter them separately. Add 95% (v / v) ethanol at a volume ratio of 3:1 and stir until a white milky gel is formed. Collect the gel, dry it, and grind it into powder to obtain plant mucilage polysaccharide powder.

[0048] S2. Weigh 1-9% (w / w) of PGPR and stir with sunflower seed oil until dissolved. Cool to room temperature, add β-carotene and vitamin D3, and stir until completely dissolved to obtain the oil phase.

[0049] S3. Dissolve vitamin B1, vitamin B2 and vitamin C in distilled water to obtain an aqueous phase;

[0050] S4. Dissolve the plant mucilage polysaccharide powder (0.01-0.09% w / v) in distilled water, add 2-10% (w / v) of MD and GA, stir evenly to obtain a wall material solution;

[0051] S5. Add the aqueous phase to the oil phase at a ratio of 1:9 to 5:5, and shear at 13000 r / min for 3 min using a high-speed shearing machine. Then mix it with the wall material solution at a ratio of 1:1 to 1:9, and continue to shear at 10000 r / min for 3 min. Then perform high-pressure homogenization. Through emulsification and homogenization, a homogenized liquid material is obtained.

[0052] S6. The homogenized liquid is spray-dried at an inlet air temperature of 120°C, an outlet air temperature of 60°C, and a flow rate of 6 mL / min to obtain multivitamin microcapsules.

[0053] The efficacy indicators for multivitamin microcapsules mainly include yield, water content, and encapsulation efficiency, and the calculation formulas are as follows:

[0054] Yield = (mass of microcapsules after spray drying / (total mass of wall material and vitamin core material)) × 100%;

[0055] Moisture content on wet basis = (Weight of microcapsules before drying - Weight of microcapsules after drying) / Weight of microcapsules before drying × 100%;

[0056] Encapsulation rate = (mass of vitamin core material encapsulated in microcapsules / mass of vitamin core material added during microcapsule preparation) × 100%.

[0057] Example 1

[0058] This invention proposes a method for preparing multivitamin microcapsules based on cactus mucilage polysaccharides.

[0059] Mainly includes:

[0060] (1) Preparation of cactus mucilage polysaccharide: Wash the cactus thoroughly with distilled water. Separate the inner pulp of the cactus using a knife and slice it. Add the above-treated material to distilled water at a volume ratio of 1:2 and let it stand for 24 hours. Then filter it separately. Add 95% (v / v) ethanol at a volume ratio of 3:1 and stir until a white emulsion gel is formed. Collect the gel, dry it at 40°C for 24 hours, and then grind it into powder for later use.

[0061] (2) Preparation of microcapsules: 5% (w / w) of PGPR was weighed and mixed with sunflower seed oil. The mixture was stirred at 65°C for 30 min until dissolved. After cooling, β-carotene and vitamin D3 were added and stirred until completely dissolved to obtain the oil phase. Vitamin B1, vitamin B2, and vitamin C were dissolved in distilled water to form the aqueous phase. Cactus mucilage polysaccharide powder was dissolved in distilled water at a concentration of 0.05% (w / v), and 6% (w / v) of MD and GA were added. The mixture was stirred evenly to form the wall material solution. The aqueous phase was added to the oil phase at a ratio of 4:6 (v / v), and sheared at 13000 r / min for 3 min. Then, it was mixed with the wall material solution at a ratio of 1:9 (v / v), sheared at 10000 r / min for 3 min, and then homogenized under high pressure at 300 bar for 3 min. The mixture was fed into a spray dryer and spray dried at an inlet air temperature of 120°C and an outlet air temperature of 60°C at a flow rate of 6 mL / min to obtain multivitamin microcapsules.

[0062] Results: Please refer to Figures 1-3 As shown in Table 1, the yield of the obtained multivitamin microcapsules was 22.48±0.91%, and the water content was 2.11±0.17%. The encapsulation efficiencies for vitamin B1, vitamin B2, vitamin C, β-carotene, and vitamin D were 68.50±0.13%, 76.18±0.18%, 84.82±0.19%, 79.29±0.13%, and 74.65±0.18%, respectively. The microstructure exhibited a relatively regular spherical shape with wrinkles and depressions on the surface. These results indicate that the microcapsules have a high yield, a relatively intact structure, and a low water content, thus improving the encapsulation efficiency of multivitamins.

[0063] Example 2

[0064] This invention proposes a method for preparing multivitamin microcapsules based on okra mucilage polysaccharides.

[0065] Mainly includes:

[0066] (1) Preparation of okra mucilage polysaccharide: Wash okra with distilled water. Remove seeds and slice okra using a knife. Add the above-treated material to distilled water at a volume ratio of 1:2 and let stand for 24 hours. Then filter separately and add 95% (v / v) ethanol at a volume ratio of 3:1. Stir until a white emulsion gel is formed. Collect the gel, dry it at 40°C for 24 hours, and then grind it into powder for later use.

[0067] (2) Preparation of microcapsules: 5% (w / w) of PGPR was weighed and mixed with sunflower seed oil. The mixture was stirred at 65°C for 30 min until dissolved. After cooling, β-carotene and vitamin D3 were added and stirred until completely dissolved to obtain the oil phase. Vitamin B1, vitamin B2, and vitamin C were dissolved in distilled water to form the aqueous phase. Okra mucilage polysaccharide powder was dissolved in distilled water at a concentration of 0.05% (w / v), and 6% (w / v) of MD and GA were added. The mixture was stirred evenly to form the wall material solution. The aqueous phase was added to the oil phase at a ratio of 4:6 (v / v), and sheared at 13000 r / min for 3 min. Then, it was mixed with the wall material solution at a ratio of 1:9 (v / v), sheared at 10000 r / min for 3 min, and then homogenized under high pressure at 300 bar for 3 min. The mixture was fed into a spray dryer and spray dried at an inlet air temperature of 120°C and an outlet air temperature of 60°C at a flow rate of 6 mL / min to obtain multivitamin microcapsules.

[0068] Results: Please refer to Figures 1-3 As shown in Table 1, the yield of the obtained multivitamin microcapsules was 23.23±0.04%, and the water content was 2.45±0.02%. The encapsulation efficiencies for vitamin B1, vitamin B2, vitamin C, β-carotene, and vitamin D were 67.22±0.03%, 76.62±0.08%, 84.76±0.15%, 79.20±0.13%, and 75.10±0.27%, respectively. The microstructure exhibited a regular spherical shape with few surface wrinkles. These results indicate that the microcapsules have a high yield, intact structure, low water content, and improved encapsulation efficiency for multivitamins.

[0069] Example 3

[0070] This invention proposes a method for preparing multivitamin microcapsules based on aloe vera mucopolysaccharides.

[0071] Mainly includes:

[0072] (1) Preparation of aloe vera mucilage polysaccharide: Wash aloe vera thoroughly with distilled water. Separate the inner pulp of aloe vera using a knife and slice it. Add the above-treated material to distilled water at a volume ratio of 1:2 and let it stand for 24 hours. Then filter it separately and add 95% (v / v) ethanol at a volume ratio of 3:1. Stir until a white emulsion gel is formed. Collect the gel, dry it at 40°C for 24 hours, and then grind it into powder for later use.

[0073] (2) Preparation of microcapsules: 5% (w / w) of PGPR was weighed and mixed with sunflower seed oil. The mixture was stirred at 65°C for 30 min until dissolved. After cooling, β-carotene and vitamin D3 were added and stirred until completely dissolved to obtain the oil phase. Vitamin B1, vitamin B2, and vitamin C were dissolved in distilled water to form the aqueous phase. Aloe vera mucilage polysaccharide powder was dissolved in distilled water at a concentration of 0.05% (w / v), and 6% (w / v) of MD and GA were added. The mixture was stirred evenly to form the wall material solution. The aqueous phase was added to the oil phase at a ratio of 4:6 (v / v), and sheared at 13000 r / min for 3 min. Then, it was mixed with the wall material solution at a ratio of 1:9 (v / v), sheared at 10000 r / min for 3 min, and then homogenized under high pressure at 300 bar for 3 min. The mixture was fed into a spray dryer and spray dried at an inlet air temperature of 120°C and an outlet air temperature of 60°C at a flow rate of 6 mL / min to obtain multivitamin microcapsules.

[0074] Results: Please refer to Figures 1-3 As shown in Table 1, the yield of the obtained multivitamin microcapsules was 25.09±0.10%, and the water content was 2.25±0.22%. The encapsulation efficiencies for vitamin B1, vitamin B2, vitamin C, β-carotene, and vitamin D were 72.82±0.49%, 82.96±0.05%, 88.58±0.05%, 79.34±0.08%, and 89.29±0.04%, respectively. The microstructure exhibited a regular spherical shape with a smooth and compact surface. These results indicate that the microcapsules possess a complete and stable structure, a high yield, and a low water content, thus improving the encapsulation efficiency of multivitamins.

[0075] Comparative Example

[0076] This invention presents a comparative experiment of different types of dual-emulsion system emulsifiers (wall materials).

[0077] Mainly includes:

[0078] The preparation method of Comparative Example 1 is the same as that of Example 1. The oil phase, water phase, water-oil mass ratio, core-wall mass ratio and homogenization conditions remain unchanged during preparation. The drying method is spray drying. The only difference is that the wall material solution is 6% (w / v) MD and GA dissolved together in distilled water.

[0079] Results: Please refer to Figures 1-3 As shown in Table 1, the yield of the multivitamin microcapsules obtained at this stage was 17.48±0.41%, and the water content was 4.02±0.04%. The encapsulation rates for vitamin B1, vitamin B2, vitamin C, β-carotene, and vitamin D were 67.75±0.09%, 74.55±0.43%, 83.34±0.10%, 79.43±0.12%, and 71.97±0.18%, respectively. The microstructure exhibited a relatively regular spherical shape with a rough, wrinkled surface. These findings indicate that the microcapsule yield was low, the water content was high, the encapsulation rate was low, and the particle integrity was poor.

[0080] Table 1. Vitamin encapsulation efficiency of multivitamin microcapsules with different wall material compositions.

[0081]

[0082] Note: Identical letters in the same column indicate no significant difference (p>0.05).

[0083] Currently, for the co-encapsulation of various vitamins, including those that are fat-soluble and water-soluble, the most commonly used method for microcapsule preparation is a dual-emulsion system (such as W / O / W emulsions) combined with spray drying technology. However, in practical applications, the emulsifier (wall material) in the dual-emulsion system dries too quickly, making it difficult to completely encapsulate the vitamins, resulting in microcapsule structures that are either uneven or incomplete. Furthermore, due to the poor chemical stability of vitamins themselves, these factors may lead to poor protection of vitamins by the microcapsules during spray drying or storage, and unsatisfactory sustained-release performance.

[0084] It should be noted that the term "comprising," or any other variation thereof, is intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising..." does not exclude the presence of other identical elements in the process, method, article, or apparatus that includes said element.

[0085] The above are merely embodiments of this application and are not intended to limit the scope of this application. Various modifications and variations can be made to this application by those skilled in the art. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of this application should be included within the scope of the claims of this application.

Claims

1. A method for preparing multivitamin microcapsules, characterized in that, Includes the following steps: S1. Select aloe vera and peel it. Mix the treated aloe vera with distilled water at a volume ratio of 1:1 to 1:4 and extract for 24 hours. Add ethanol with a volume fraction of more than 75% for alcohol precipitation. Collect the white milky gel and dry it at 20℃ to 60℃ for 12 to 36 hours to obtain aloe vera mucopolysaccharide powder. S2. Mix polyglycerol polyricinoleate with sunflower seed oil at 1%~9% w / w, stir at 45℃~85℃ for 10min~50min until completely dissolved, heat to 55℃~75℃ and cool, add β-carotene and / or vitamin D3, stir evenly to obtain the oil phase; S3. Dissolve vitamin B1, vitamin B2, and / or vitamin C in water to obtain an aqueous phase; S4. Dissolve the aloe vera mucilage polysaccharide powder in water at 0.01%~0.09% w / v, then add maltodextrin and gum arabic, the concentration of maltodextrin or gum arabic is 2%~10% w / v, stir evenly to obtain the wall material solution. S5. Add the aqueous phase to the oil phase at a water-to-oil mass ratio of 1:9 to 5:5, then mix with the wall material solution. Perform high-speed shearing at 10000 r / min to 16000 r / min for 1 min to 10 min, followed by high-pressure homogenization at 100 bar to 500 bar for 1 min to 10 min to obtain the homogenized liquid material; wherein the core-to-wall mass ratio is 1:1 to 1:

9. S6. The homogenized liquid material is spray-dried at an inlet air temperature of 115℃~125℃ and an outlet air temperature of 50℃~70℃, with a feed flow rate of 3mL / min~10mL / min to obtain multivitamin microcapsules.

2. The method for preparing multivitamin microcapsules according to claim 1, characterized in that, The ethanol concentration used for the alcohol precipitation is above 80%.

3. A multivitamin microcapsule, characterized in that, The multivitamin microcapsules are prepared by the method described in claim 1 or claim 2.

4. The application of the multivitamin microcapsules according to claim 3 in the fields of pharmaceuticals, feed or food.

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