Continuous monitoring method for neonatal jaundice and related device

Abstract

The invention discloses a continuous monitoring method for neonatal jaundice and a related device. The method comprises the steps that a sensor module arranged on a patch or a bracelet is used for percutaneously measuring the bilirubin level of a neonate; the measurement data of the photoelectric sensor is corrected according to the data of the temperature sensor, the bilirubin level of the newborn is calculated through a preset bilirubin model based on the corrected data of the photoelectric sensor, and the preset bilirubin model comprises a light absorption model and a dynamic correction model; establishing a relation model of light absorption and bilirubin concentration by the light absorption model; the dynamic correction model adjusts parameters of the light absorption model; and transmitting the bilirubin level to a remote server, and when the bilirubin level exceeds a preset alarm threshold, generating an alarm signal and pushing the alarm signal to a medical staff client and / or a parent client. According to the invention, personalized continuous monitoring of neonatal jaundice is realized through a dynamic correction model, an intelligent alarm threshold, closed-loop control and auxiliary treatment means.

Description

Technical Field

[0001] The present invention relates to the technical field of medical device assistance, and particularly to a method and device for continuously monitoring neonatal jaundice, and a computing device. Background Art

[0002] Neonatal jaundice is a common disease. Approximately 80% of newborns will develop jaundice, and about 10% of them require medical intervention. Severe hyperbilirubinemia may lead to acute bilirubin encephalopathy or kernicterus, causing permanent nerve damage such as cerebral palsy and hearing loss. Currently, clinically, the bilirubin levels of newborns are mainly monitored by intermittent blood sampling (TSB) or transcutaneous detection (TcB). However, it is impossible to monitor the dynamic changes of bilirubin in real time, and high-risk cases are likely to be missed. Blood sampling detection brings pain and infection risks, increasing the pain of children. Moreover, the compliance is poor, and it is difficult to ensure the continuity and accuracy of follow-up.

[0003] To solve the above problems, the present invention discloses a method for continuously monitoring neonatal jaundice, which realizes personalized continuous monitoring of neonatal jaundice through a dynamic correction model, an intelligent alarm threshold, a closed-loop control, and an auxiliary treatment means. Summary of the Invention

[0004] In view of the above problems, the present invention provides a method and device for continuously monitoring neonatal jaundice, and a computing device.

[0005] According to one aspect of the present invention, there is provided a method for continuously monitoring neonatal jaundice, including:

[0006] Measuring the bilirubin level of a newborn transcutaneously using a sensor module disposed on a patch or a bracelet, wherein the sensor module includes a photoelectric sensor and a temperature sensor, the photoelectric sensor is used to measure the light absorption value of bilirubin under the skin, and the temperature sensor is used to correct the measurement data of the photoelectric sensor;

[0007] Correcting the measurement data of the photoelectric sensor according to the data of the temperature sensor, and calculating the bilirubin level of the newborn based on the corrected photoelectric sensor data. The preset bilirubin model includes a light absorption model and a dynamic correction model. The light absorption model establishes a relationship model between light absorption and bilirubin concentration according to the skin light absorption characteristics; the dynamic correction model dynamically adjusts the parameters of the light absorption model according to the age, weight, and skin color of the newborn;

[0008] Transmitting the bilirubin level to a remote server, and generating an alarm signal and pushing it to a medical staff client and / or a parent client when the bilirubin level exceeds a preset alarm threshold.

[0009] In an optional manner, the parameter adjustment formula of the dynamic correction model is:

[0010]

[0011] Among them, k(t) is the dynamic correction coefficient; k0 is the initial correction coefficient; is the neonatal weight change rate; is the change rate of skin bilirubin concentration over time; γ is the temperature sensitivity coefficient; T(t) is the real-time skin temperature; T0 is the reference temperature threshold.

[0012] In an optional manner, the setting formula of the preset alarm threshold is:

[0013]

[0014] Among them, B0 is the initial reference threshold; δ is the bilirubin rising rate weight; is the positive change rate extraction operator; η is the historical fluctuation attenuation coefficient; ΔB i is the bilirubin decrease amount after the i-th treatment; t i is the treatment timestamp; μ and σ are the mean and standard deviation of the treatment interval respectively.

[0015] In an optional manner, the formula for correcting the measurement data of the optoelectronic sensor is:

[0016]

[0017] Among them, C corrected is the corrected bilirubin concentration value; C raw is the original bilirubin concentration measurement value; T is the temperature of the skin surface or near the probe measured by the temperature sensor; T ref is the reference point for temperature correction; T range is the temperature fluctuation range; a n and b n are the Fourier series correction coefficients; n is the order of the Fourier series; N is the maximum order.

[0018] In an optional manner, the sensor module includes:

[0019] At least 12 photodiodes, distributed on the patch surface in a 4×3 matrix, each diode covering a wavelength range of 400 - 500 nm, with a central wavelength interval of 10 nm;

[0020] A pressure-sensitive conductive rubber layer for monitoring the contact pressure between the patch and the skin, triggering a self-check program when the pressure < 5 kPa;

[0021] A microfluidic channel network containing a bilirubin standard solution for performing in-situ self-calibration;

[0022] A wireless charging coil and an energy harvesting module generate electricity through the micro-vibrations produced by the movements of a newborn, enabling the sensor module to continuously operate for more than 72 hours.

[0023] The waterproof and breathable film layer is made of a polyurethane / fluorocarbon composite material.

[0024] In an alternative embodiment, the sensor module further includes an intelligent adjustment system that automatically adjusts and fixes the sensor module to the skin of the newborn through a robotic arm and a micro-motor.

[0025] In an alternative embodiment, the sensor module integrates a closed-loop control module that dynamically adjusts the treatment parameters of the patch or bracelet according to the real-time bilirubin level of the newborn.

[0026] Wherein, the treatment parameters include the irradiation intensity, irradiation duration, and irradiation frequency of the blue LED.

[0027] The patch or bracelet integrates a micro-vibration motor that generates vibrations when the bilirubin level continues to rise.

[0028] In an alternative embodiment, the sensor module adopts an integrated multi-spectral analysis chip that integrates multiple narrow-band LED light sources and a photodetector array.

[0029] According to another aspect of the present invention, there is provided a continuous neonatal jaundice monitoring device, comprising:

[0030] A transcutaneous measurement module for transcutaneously measuring the bilirubin level of a newborn using a sensor module provided on a patch or bracelet, wherein the sensor module includes a photoelectric sensor and a temperature sensor, the photoelectric sensor is used to measure the light absorption value of bilirubin under the skin, and the temperature sensor is used to correct the measurement data of the photoelectric sensor.

[0031] A data correction module for correcting the measurement data of the photoelectric sensor according to the data of the temperature sensor, and calculating the bilirubin level of the newborn through a preset bilirubin model based on the corrected photoelectric sensor data. The preset bilirubin model includes a light absorption model and a dynamic correction model. The light absorption model establishes a relationship model between light absorption and bilirubin concentration according to the skin light absorption characteristics; the dynamic correction model dynamically adjusts the parameters of the light absorption model according to the age, weight, and skin color of the newborn.

[0032] A data alarm module for transmitting the bilirubin level to a remote server, and generating an alarm signal and pushing it to the medical staff client and / or the parent client when the bilirubin level exceeds a preset alarm threshold.

[0033] According to another aspect of the present invention, there is provided a computing device, including: a processor, a memory, a communication interface, and a communication bus, where the processor, the memory, and the communication interface complete communication with each other through the communication bus;

[0034] The memory is used to store at least one executable instruction, and the executable instruction causes the processor to perform operations corresponding to the above-mentioned continuous monitoring method for neonatal jaundice.

[0035] According to the solution provided by the present invention, a sensor module disposed on a patch or a bracelet is used to transcutaneously measure the bilirubin level of a neonate. Among them, the sensor module includes a photoelectric sensor and a temperature sensor. The photoelectric sensor is used to measure the light absorption value of bilirubin under the skin, and the temperature sensor is used to correct the measurement data of the photoelectric sensor; the measurement data of the photoelectric sensor is corrected according to the data of the temperature sensor, and based on the corrected data of the photoelectric sensor, the bilirubin level of the neonate is calculated through a preset bilirubin model. Among them, the preset bilirubin model includes a light absorption model and a dynamic correction model. The light absorption model establishes a relationship model between light absorption and bilirubin concentration according to the skin light absorption characteristics; the dynamic correction model dynamically adjusts the parameters of the light absorption model according to the age, weight, and skin color of the neonate; the bilirubin level is transmitted to a remote server, and when the bilirubin level exceeds a preset alarm threshold, an alarm signal is generated and pushed to the medical staff client and / or the parent client. The present invention realizes personalized continuous monitoring of neonatal jaundice through a dynamic correction model, an intelligent alarm threshold, closed-loop control, and auxiliary treatment means.

[0036] The above description is only an overview of the technical solution of the present invention. In order to be able to understand the technical means of the present invention more clearly, it can be implemented according to the content of the description. And in order to make the above and other purposes, features, and advantages of the present invention more obvious and understandable, the following specifically illustrates the embodiments of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0037] By reading the detailed description of the preferred embodiments below, various other advantages and benefits will become clear to those of ordinary skill in the art. The drawings are only for the purpose of showing the preferred embodiments and are not considered to be a limitation of the present invention. Moreover, throughout the drawings, the same reference numerals are used to represent the same components. In the drawings:

[0038] Figure 1 A flowchart showing the continuous monitoring method for neonatal jaundice according to an embodiment of the present invention is shown;

[0039] Figure 2 A framework diagram showing the continuous monitoring device for neonatal jaundice according to an embodiment of the present invention is shown;

[0040] Figure 3 The structure diagram of the computing device according to an embodiment of the present invention is shown. Detailed implementation manners

[0041] The exemplary embodiments of the present invention will be described in more detail below with reference to the accompanying drawings. Although the exemplary embodiments of the present invention are shown in the drawings, it should be understood that the present invention can be implemented in various forms and should not be limited by the embodiments set forth herein. On the contrary, these embodiments are provided so that the present invention can be more thoroughly understood and the scope of the present invention can be fully conveyed to those skilled in the art.

[0042] Figure 1 The flowchart of the continuous neonatal jaundice monitoring method according to an embodiment of the present invention is shown. Specifically, as Figure 1 shown, the method includes the following steps:

[0043] Step S101: Use the sensor module disposed on the patch or bracelet to transcutaneously measure the bilirubin level of the neonate. Wherein, the sensor module includes a photoelectric sensor and a temperature sensor. The photoelectric sensor is used to measure the light absorption value of bilirubin under the skin, and the temperature sensor is used to correct the measurement data of the photoelectric sensor.

[0044] In this embodiment, the pain and infection risks brought by traditional blood tests are avoided, the comfort of the child is improved, the dynamic changes of the bilirubin level are continuously monitored, the deficiency of intermittent detection is made up, and it is helpful to detect high-risk cases and disease changes earlier. Measuring with a photoelectric sensor avoids the subjective error of visual assessment and improves the accuracy and reliability of the monitoring. Temperature correction takes into account the influence of skin temperature on the measurement result and performs real-time correction through a temperature sensor, further improving the accuracy of the measurement.

[0045] Specifically, a photoelectric sensor sensitive to bilirubin is selected, and its working wavelength range covers the main area of the bilirubin absorption spectrum. The photoelectric sensor emits light of a specific wavelength and irradiates the skin of the neonate. Part of the light is absorbed and scattered by the skin tissue, and among them, bilirubin will absorb light of a specific wavelength. The photoelectric sensor receives the reflected light and analyzes the change in the intensity of the light. By analyzing the change in the light intensity at different wavelengths, the concentration of bilirubin (light absorption model) is calculated. The measurement data of the photoelectric sensor is corrected using the skin temperature measured by the temperature sensor to eliminate the influence of temperature on the measurement result.

[0046] For example, jaundice appears in a premature infant on the third day after birth. Medical staff gently paste the patch on the forehead or chest skin of the infant, and the patch is in close contact with the skin. The pressure sensor inside the patch continuously monitors the contact pressure between the patch and the skin, and automatically gives a prompt if the pressure is insufficient. The photoelectric sensor on the patch starts to work and measures bilirubin every few minutes. The temperature sensor synchronously monitors the skin temperature of the infant. The microprocessor inside the patch corrects the raw data measured by the photoelectric sensor according to the value of the temperature sensor to eliminate the influence of temperature. Then, the current bilirubin level of the infant is calculated using a preset bilirubin model. The patch sends the bilirubin level data to the central monitoring system in the ward via Bluetooth. The attending physician can view the bilirubin monitoring curve of the infant in real time on their mobile phone APP and set the alarm threshold. If the bilirubin level of the infant exceeds the preset alarm threshold, an alarm message is automatically sent to the mobile phone APP and computer client of the attending physician to remind the doctor to intervene in a timely manner.

[0047] In an alternative embodiment, the sensor module includes:

[0048] At least 12 photodiodes, distributed on the patch surface in a 4×3 matrix, each diode covering a wavelength range of 400 - 500 nm, with a central wavelength interval of 10 nm;

[0049] A pressure-sensitive conductive rubber layer for monitoring the contact pressure between the patch and the skin, triggering a self-check program when the pressure < 5 kPa;

[0050] A microfluidic channel network containing a bilirubin standard solution for performing in-situ self-calibration;

[0051] A wireless charging coil and an energy harvesting module that generate electricity through the micro-vibrations generated by the movement of the newborn to maintain the continuous operation of the sensor module for > 72 hours;

[0052] A waterproof and breathable membrane layer made of a polyurethane / fluorocarbon composite material.

[0053] In this embodiment, multiple photodiodes (12 in number) cover the wavelength range of 400 - 500 nm with a central wavelength interval of 10 nm, improving the accuracy of bilirubin detection. Lights of different wavelengths have different absorption degrees for bilirubin. By analyzing the absorption values at multiple wavelengths, the bilirubin concentration can be more accurately inferred, reducing the influence of other factors (such as skin pigment differences). The 4x3 matrix distribution improves the measurement range and averages the influence brought by skin heterogeneity. The pressure-sensitive conductive rubber layer ensures good contact between the patch and the skin. The microfluidic channel network contains bilirubin standard solution for in-situ self-calibration, eliminating the influence of sensor drift and environmental factors on the measurement results. The wireless charging coil is combined with an energy harvesting module (generating electricity through micro-vibration), extending the battery life of the sensor module (>72 hours), reducing the frequency of replacement or charging, and reducing the nursing burden. The polyurethane / fluorocarbon composite material is used as the waterproof and breathable membrane layer, which can not only prevent sweat and external liquids from entering and affecting the sensor performance, but also ensure the breathability of the skin, reducing allergies or discomfort.

[0054] In an alternative manner, the sensor module further includes an intelligent adjustment system, which realizes the automatic adjustment and fixation of the sensor module to the skin of the newborn through a robotic arm and a micro-motor.

[0055] In this embodiment, the activities and postures of the newborn often cause the patch position to shift. The intelligent adjustment system can automatically adjust the position and pressure of the sensor module to ensure good contact with the skin of the newborn, reducing measurement errors caused by factors such as patch loosening and uneven pressure, and improving the reliability of bilirubin monitoring. The automatic adjustment system also adjusts the patch position in a gentler way to avoid discomfort or damage to the skin of the newborn.

[0056] In an alternative manner, the sensor module integrates a closed-loop control module, and the closed-loop control module dynamically adjusts the treatment parameters of the patch or the bracelet according to the real-time bilirubin level of the newborn;

[0057] Wherein, the treatment parameters include the irradiation intensity, irradiation duration, and irradiation frequency of the blue LED;

[0058] The patch or the bracelet integrates a micro-vibration motor, and when the bilirubin level continuously rises, the micro-vibration motor generates vibration.

[0059] In this embodiment, the sensor module monitors the bilirubin level of the newborn in real time through the closed-loop control module to ensure the timeliness and accuracy of the data. According to the real-time monitored bilirubin level, the closed-loop control module dynamically adjusts the treatment parameters, such as the irradiation intensity, irradiation duration, and irradiation frequency of the blue light LED, so as to provide a personalized treatment plan. When the bilirubin level continues to rise, the micro vibration motor generates vibration to remind medical staff and parents to take measures in time, improving the safety of the newborn. The automatic adjustment function of the closed-loop control module reduces the intervention frequency of medical staff and parents and improves the user experience.

[0060] In an optional manner, the sensor module adopts an integrated multi-spectral analysis chip, and the integrated multi-spectral analysis chip integrates a plurality of narrow-band LED light sources and a photodetector array.

[0061] In this embodiment, traditional photoelectric sensors may rely on only a few specific wavelengths and are easily interfered by other skin components (such as melanin and hemoglobin). The integrated multi-spectral analysis chip integrates a plurality of narrow-band LED light sources and a photodetector array, covering a wider spectral range. By analyzing the absorption and reflection of light at different wavelengths, the information of bilirubin under the skin can be obtained more accurately.

[0062] Step S102, correct the measurement data of the photoelectric sensor according to the data of the temperature sensor. Based on the corrected photoelectric sensor data, calculate the bilirubin level of the newborn through a preset bilirubin model. Among them, the preset bilirubin model includes a light absorption model and a dynamic correction model. The light absorption model establishes a relationship model between light absorption and bilirubin concentration according to the skin light absorption characteristics; the dynamic correction model dynamically adjusts the parameters of the light absorption model according to the age, weight, and skin color of the newborn.

[0063] In this embodiment, temperature affects the optical properties of the skin and the performance of the photoelectric sensor. Using the temperature sensor to correct the data of the photoelectric sensor can effectively reduce the error introduced by temperature changes, thereby improving the accuracy of bilirubin level measurement. The dynamic correction model takes into account the individual differences in the age, weight, and skin color of the newborn, and realizes more accurate personalized bilirubin monitoring by dynamically adjusting the model parameters. The whole process is carried out in real time to provide continuous and dynamic bilirubin level monitoring data, which helps to detect abnormal changes in bilirubin levels in time.

[0064] In an optional manner, the formula for correcting the measurement data of the photoelectric sensor is:

[0065]

[0066] Where C corrected is the corrected bilirubin concentration value; C rawis the original bilirubin concentration measurement value; T is the temperature of the skin surface or near the probe measured by the temperature sensor; T ref is the reference point for temperature correction; T range is the temperature fluctuation range; a n and b n are the Fourier series correction coefficients; n is the order of the Fourier series; N is the maximum order.

[0067] In this embodiment, the Fourier series correction coefficients capture the influence of temperature changes on the measurement data of the optoelectronic sensor, thereby improving the accuracy of bilirubin concentration measurement. By inputting real-time temperature data, the correction parameters can be dynamically adjusted to adapt to the changes in the skin temperature of newborns.

[0068] In an alternative manner, the parameter adjustment formula of the dynamic correction model is:

[0069]

[0070] where k(t) is the dynamic correction coefficient; k0 is the initial correction coefficient; is the change rate of the newborn's weight; is the change rate of the skin bilirubin concentration over time; γ is the temperature sensitivity coefficient; T(t) is the real-time skin temperature; T0 is the reference temperature threshold.

[0071] In this embodiment, different from intermittent detection, it can continuously monitor the bilirubin level of newborns and detect abnormalities early. The dynamic correction takes into account factors such as the change in the newborn's weight, the change in the skin bilirubin concentration, and the skin temperature, further improving the measurement accuracy.

[0072] Step S103, transmit the bilirubin level to the remote server. When the bilirubin level exceeds the preset alarm threshold, generate an alarm signal and push it to the medical staff client and / or the parent client.

[0073] In this embodiment, the neonate starts to receive jaundice monitoring 24 hours after birth, and the sensor module is worn on the wrist of the neonate. The sensor module measures the bilirubin level and body temperature every 15 minutes and transmits the data to the remote server via Bluetooth BLE. After receiving the data, the remote server monitors the bilirubin level in real time. The initial benchmark threshold is set at 12 mg / dL and is dynamically adjusted according to the weight change rate and skin bilirubin concentration change rate of the neonate. After 6 hours of monitoring, the server detects that the bilirubin level reaches 15 mg / dL, exceeding the current preset alarm threshold of 14 mg / dL. The server immediately generates an alarm signal and sends the alarm information to the medical staff client and the parent client via the push service. The medical staff client displays the alarm information and provides functions to view historical data and trend charts. The medical staff can judge the condition of the neonate based on the alarm information and historical data. The parent client displays the alarm information, prompting the parents to pay attention to the baby's health status and communicate with the medical staff in a timely manner.

[0074] In an alternative approach, the formula for setting the preset alarm threshold is:

[0075]

[0076] where B0 is the initial benchmark threshold; δ is the bilirubin rising rate weight; is the positive change rate extraction operator; η is the historical fluctuation attenuation coefficient; ΔB i is the bilirubin decrease amount after the i-th treatment; t i is the treatment timestamp; μ and σ are the mean and standard deviation of the treatment interval respectively.

[0077] According to the solution provided by the present invention, a sensor module disposed on a patch or a bracelet is used to transcutaneously measure the bilirubin level of a neonate. The sensor module includes a photoelectric sensor and a temperature sensor. The photoelectric sensor is used to measure the light absorption value of bilirubin under the skin, and the temperature sensor is used to correct the measurement data of the photoelectric sensor; the measurement data of the photoelectric sensor is corrected according to the data of the temperature sensor, and based on the corrected data of the photoelectric sensor, the bilirubin level of the neonate is calculated through a preset bilirubin model. The preset bilirubin model includes a light absorption model and a dynamic correction model. The light absorption model establishes a relationship model between light absorption and bilirubin concentration according to the skin light absorption characteristics; the dynamic correction model dynamically adjusts the parameters of the light absorption model according to the age, weight and skin color of the neonate; the bilirubin level is transmitted to the remote server, and when the bilirubin level exceeds the preset alarm threshold, an alarm signal is generated and pushed to the medical staff client and / or the parent client. The present invention realizes personalized continuous monitoring of neonatal jaundice through a dynamic correction model, an intelligent alarm threshold, closed-loop control and auxiliary treatment means.

[0078] Figure 2 The framework schematic diagram of the neonatal jaundice continuous monitoring device according to an embodiment of the present invention is shown. The neonatal jaundice continuous monitoring device includes:

[0079] A transcutaneous measurement module 210 for transcutaneously measuring the bilirubin level of a neonate using a sensor module disposed on a patch or a bracelet. The sensor module includes a photoelectric sensor and a temperature sensor. The photoelectric sensor is used to measure the light absorption value of bilirubin under the skin, and the temperature sensor is used to correct the measurement data of the photoelectric sensor;

[0080] A data correction module 220 for correcting the measurement data of the photoelectric sensor according to the data of the temperature sensor, and calculating the bilirubin level of the neonate through a preset bilirubin model based on the corrected photoelectric sensor data. The preset bilirubin model includes a light absorption model and a dynamic correction model. The light absorption model establishes a relationship model between light absorption and bilirubin concentration according to the skin light absorption characteristics; the dynamic correction model dynamically adjusts the parameters of the light absorption model according to the age, weight and skin color of the neonate;

[0081] A data alarm module 230 for transmitting the bilirubin level to a remote server, and generating an alarm signal and pushing it to a medical staff client and / or a parent client when the bilirubin level exceeds a preset alarm threshold.

[0082] Figure 3 The structural schematic diagram of an embodiment of the computing device according to the present invention is shown. The specific implementation of the computing device in the specific embodiment of the present invention is not limited.

[0083] As Figure 3 shown, the computing device may include: a processor 302, a communication interface 304, a memory 306, and a communication bus 308.

[0084] Among them: The processor 302, the communication interface 304, and the memory 306 communicate with each other through the communication bus 308. The communication interface 304 is used to communicate with network elements of other devices such as a client or other servers. The processor 302 is used to execute a program 310, and specifically may execute relevant steps in the above-mentioned embodiment of the neonatal jaundice continuous monitoring method.

[0085] Specifically, the program 310 may include program code, and the program code includes computer operation instructions.

[0086] The processor 302 may be a central processing unit (CPU), or an application specific integrated circuit (ASIC), or one or more integrated circuits configured to implement the embodiments of the present invention. One or more processors included in the computing device may be of the same type of processor, such as one or more CPUs; or may be of different types of processors, such as one or more CPUs and one or more ASICs.

[0087] A memory 306 for storing a program 310. The memory 306 may include high-speed RAM memory and may also include non-volatile memory, such as at least one disk memory.

[0088] According to the solution provided by the present invention, a sensor module disposed on a patch or a bracelet is used to transdermally measure the bilirubin level of a newborn. The sensor module includes a photoelectric sensor and a temperature sensor. The photoelectric sensor is used to measure the light absorption value of bilirubin under the skin, and the temperature sensor is used to correct the measurement data of the photoelectric sensor; the measurement data of the photoelectric sensor is corrected according to the data of the temperature sensor, and based on the corrected data of the photoelectric sensor, the bilirubin level of the newborn is calculated through a preset bilirubin model. The preset bilirubin model includes a light absorption model and a dynamic correction model. The light absorption model establishes a relationship model between light absorption and bilirubin concentration according to the skin light absorption characteristics; the dynamic correction model dynamically adjusts the parameters of the light absorption model according to the age, weight, and skin color of the newborn; the bilirubin level is transmitted to a remote server, and when the bilirubin level exceeds a preset alarm threshold, an alarm signal is generated and pushed to the medical staff client and / or the parent client. The present invention realizes personalized continuous monitoring of neonatal jaundice through a dynamic correction model, an intelligent alarm threshold, a closed-loop control, and an auxiliary treatment means.

[0089] Those skilled in the art can understand that the modules in the devices in the embodiments can be adaptively changed and set in one or more devices different from the embodiments. The modules or units or components in the embodiments can be combined into one module or unit or component, and in addition, they can be divided into multiple sub-modules or sub-units or sub-components. Except that at least some of such features and / or processes or units are mutually exclusive, any combination can be adopted to combine all the features disclosed in this specification (including the accompanying claims, abstract and drawings) and all the processes or units of any method or device so disclosed. Unless otherwise clearly stated, each feature disclosed in this specification (including the accompanying claims, abstract and drawings) can be replaced by an alternative feature providing the same, equivalent or similar purpose. In addition, those skilled in the art can understand that although some of the embodiments herein include certain features included in other embodiments rather than other features, the combination of the features of different embodiments means that it is within the scope of the present invention and forms different embodiments. For example, in the following claims, any one of the claimed embodiments can be used in any combination. The present invention can be implemented by means of hardware including several different elements and by means of a properly programmed computer. In the unit claims listing several devices, several of these devices can be embodied by the same hardware item. The steps in the above embodiments, unless otherwise specified, should not be construed as a limitation on the execution order.

Claims

1. A continuous monitoring method for neonatal jaundice, characterized in that, Comprising: Using a sensor module disposed on a patch or a bracelet to transdermally measure the bilirubin level of a newborn. The sensor module includes a photoelectric sensor and a temperature sensor. The photoelectric sensor is used to measure the light absorption value of bilirubin under the skin, and the temperature sensor is used to correct the measurement data of the photoelectric sensor; Correcting the measurement data of the photoelectric sensor according to the data of the temperature sensor. Based on the corrected photoelectric sensor data, calculating the bilirubin level of the newborn through a preset bilirubin model. The preset bilirubin model includes a light absorption model and a dynamic correction model. The light absorption model establishes a relationship model between light absorption and bilirubin concentration according to the skin light absorption characteristics; the dynamic correction model dynamically adjusts the parameters of the light absorption model according to the age, weight and skin color of the newborn; Transmitting the bilirubin level to a remote server. When the bilirubin level exceeds a preset alarm threshold, generating an alarm signal and pushing it to the medical staff client and / or the parent client.

2. The continuous neonatal jaundice monitoring method according to claim 1, characterized in that, The parameter adjustment formula of the dynamic correction model is: Among them, k(t) is the dynamic correction coefficient; k0 is the initial correction coefficient; is the neonatal weight change rate; is the change rate of skin bilirubin concentration over time; γ is the temperature sensitivity coefficient; T(t) is the real-time skin temperature; T0 is the reference temperature threshold.

3. The continuous neonatal jaundice monitoring method according to claim 1, wherein, The setting formula of the preset alarm threshold is: Among them, B0 is the initial reference threshold; δ is the weight of the bilirubin rising rate; is the positive change rate extraction operator; η is the historical fluctuation attenuation coefficient; ΔB i is the bilirubin decrease amount after the i-th treatment; t i is the treatment timestamp; μ and σ are the mean and standard deviation of the treatment interval respectively.

4. The continuous neonatal jaundice monitoring method according to claim 1, characterized in that, The formula for correcting the measurement data of the photoelectric sensor is: Among them, C corrected is the corrected bilirubin concentration value; C raw is the original bilirubin concentration measurement value; T is the temperature of the skin surface or near the probe measured by the temperature sensor; T ref is the reference point for temperature correction; T range is the temperature fluctuation range; a n and b n are the Fourier series correction coefficients; n is the order of the Fourier series; N is the maximum order.

5. The continuous neonatal jaundice monitoring method according to claim 1, characterized in that, The sensor module includes: At least 12 photodiodes, distributed on the surface of the patch in a 4×3 matrix, each diode covering a wavelength range of 400 - 500nm, with a central wavelength interval of 10nm; A pressure-sensitive conductive rubber layer for monitoring the contact pressure between the patch and the skin, and triggering a self-check program when the pressure < 5kPa; A microfluidic channel network containing a bilirubin standard solution for performing in-situ self-calibration; A wireless charging coil and an energy harvesting module, generating electricity through the micro-vibrations generated by the movement of the newborn to maintain the continuous operation of the sensor module for > 72 hours; A waterproof and breathable membrane layer made of a polyurethane / fluorocarbon composite material.

6. The continuous neonatal jaundice monitoring method according to claim 1, characterized in that, The sensor module further includes an intelligent adjustment system, which realizes the automatic adjustment and fixation of the sensor module and the skin of the newborn through a robotic arm and a micro-motor.

7. The continuous neonatal jaundice monitoring method according to claim 1, wherein, The sensor module integrates a closed-loop control module, and the closed-loop control module dynamically adjusts the treatment parameters of the patch or the bracelet according to the real-time bilirubin level of the newborn; Wherein, the treatment parameters include the irradiation intensity, irradiation duration and irradiation frequency of the blue LED; The patch or the bracelet integrates a micro-vibration motor, and when the bilirubin level continuously rises, the micro-vibration motor generates vibrations.

8. The continuous neonatal jaundice monitoring method according to claim 1, wherein, The sensor module adopts an integrated multi-spectral analysis chip, and the integrated multi-spectral analysis chip integrates multiple narrow-band LED light sources and a photodetector array.

9. A continuous neonatal jaundice monitoring device, characterized in that, Including: A transdermal measurement module for using a sensor module disposed on a patch or a bracelet to transdermally measure the bilirubin level of a newborn. The sensor module includes a photoelectric sensor and a temperature sensor. The photoelectric sensor is used to measure the light absorption value of bilirubin under the skin, and the temperature sensor is used to correct the measurement data of the photoelectric sensor; A data correction module is used to correct the measurement data of the photoelectric sensor according to the data of the temperature sensor. Based on the corrected photoelectric sensor data, the bilirubin level of the newborn is calculated through a preset bilirubin model. Among them, the preset bilirubin model includes a light absorption model and a dynamic correction model. The light absorption model establishes a relationship model between light absorption and bilirubin concentration according to the skin light absorption characteristics; the dynamic correction model dynamically adjusts the parameters of the light absorption model according to the age, weight and skin color of the newborn. A data alarm module is used to transmit the bilirubin level to a remote server. When the bilirubin level exceeds a preset alarm threshold, an alarm signal is generated and pushed to the medical staff client and / or the parent client.

10. A computing device, comprising: A processor, a memory, a communication interface and a communication bus. The processor, the memory and the communication interface complete mutual communication through the communication bus. The memory is used to store at least one executable instruction, and the executable instruction causes the processor to execute the operations corresponding to the above-mentioned continuous monitoring method for neonatal jaundice.

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