Auxiliary detection device for measuring release rate of microneedle transdermal patch

Abstract

The invention discloses an auxiliary detection device for determining the release degree of a microneedle transdermal patch, which comprises a screw cap and a screw bottom, the screw cap and the screw bottom are assembled and connected through threads, a cavity is formed after the screw cap and the screw bottom are assembled, and a front baffle plate, a middle glue layer and a rear baffle plate are sequentially laminated in the cavity along the direction from the screw cap to the screw bottom; first through holes are formed in the middle of the front blocking piece and the middle of the middle adhesive layer, the edge of the microneedle transdermal patch is attached to the middle adhesive layer, a microneedle array of the microneedle transdermal patch is arranged in the first through holes in a penetrating mode, and second through holes are formed in the screw cap right opposite to the microneedle array; and the rear separation blade is in contact connection with the middle adhesive layer and the micro-needle transdermal patch. The device disclosed by the invention is simple in structure and convenient to assemble, simulates a medication scene, and realizes drug release of the side, in contact with the skin, of the microneedle transdermal patch, so that a measurement result is accurate and precise, the microneedle quality condition and the drug release condition can be effectively reflected, and a guarantee is provided for research and standardization of microneedle products.

Description

Technical Field

[0001] The present invention relates to the technical field of pharmaceutical product testing, and particularly relates to an auxiliary detection device for determining the release rate of a microneedle transdermal patch. Background Art

[0002] At present, in the field of drug research and development, the development of new formulations is changing with each passing day. As a special dosage form among transdermal patches, the microneedle transdermal patch generally uses one or several of high-molecular materials such as sodium hyaluronate, polyvinyl alcohol, and silk fibroin, and loads drugs through a special process to form an array of "small needles". When using the microneedle transdermal patch, the array composed of "small needles" is closely attached to the skin. Microneedles have obvious advantages over traditional transdermal patches in terms of drug delivery method, drug delivery efficiency, toxic and side effects, and patient compliance, so they have broad development space.

[0003] The quality control of drugs is a necessary means to ensure the safety and effectiveness of drugs. In the quality control of transdermal patches, the release rate is a key evaluation index. The methods for determining the drug release rate in traditional transdermal patches are difficult to be applied to microneedle transdermal patches. The methods for determining the drug release rate in traditional transdermal patches are: the paddle-disk method and the rotating cylinder method, which are not applicable to microneedle transdermal patches.

[0004] The paddle-disk method uses a double-layer metal mesh to "clamp" the patch to be tested in the middle, and determines its release rate by measuring the unidirectional release of the patch. Due to the good water permeability of the double-layer metal mesh, the microneedles will "swell" and / or "dissolve" in the mesh and "release drugs" in all directions, which does not conform to the situation of drug release on the side in contact with the skin in the actual drug delivery scenario. The obtained release rate results will be too high, and the drug release time will be too short, which cannot guide and evaluate the quality and process of microneedles.

[0005] The rotating cylinder method is to "closely attach" the back side of the patch to the rotating cylinder and release drugs into the medium. Due to the different hardness of microneedles and the inability to ensure that they are completely attached to the rotating cylinder, the rotating cylinder method is not applicable to microneedle transdermal patches.

[0006] In summary, although microneedle transdermal patches are also transdermal drug delivery preparations, their differences in materials, hardness, structure, etc. result in the inapplicability of the traditional methods for determining the drug release rate of transdermal patches. Therefore, with the increasing popularity of microneedle dosage forms, an auxiliary device (equipment) that can effectively and reasonably detect their release rate is urgently needed to complete the closed-loop operation of microneedle quality control. Summary of the Invention

[0007] In view of the deficiencies in the prior art, the present invention provides an auxiliary detection device for measuring the release rate of a microneedle transdermal patch, which is used to effectively and reasonably assist in the drug release rate of the microneedle transdermal patch, so as to provide more accurate detection results, and further effectively guide and evaluate the quality and process of microneedles. The design of the auxiliary device of the present invention is based on the characteristics of the material, structure, etc. of the microneedle, and combines the drug delivery method of the microneedle to simulate the drug delivery scenario to the greatest extent, so as to accurately measure the drug release rate of the microneedle product and accurately control the quality of the microneedle; this auxiliary measurement device is used in conjunction with a conventional dissolution tester in the laboratory to provide a new method for the accurate test of the drug release rate of the microneedle transdermal patch and has good applicability.

[0008] To solve the above technical problems, the present invention provides an auxiliary detection device for measuring the release rate of a microneedle transdermal patch, including a screw cap and a screw bottom. The screw cap and the screw bottom are assembled and connected by threads. After the screw cap and the screw bottom are assembled, a cavity is formed. In the cavity, a front baffle, a middle adhesive layer and a rear baffle are sequentially stacked in the direction from the screw cap to the screw bottom;

[0009] First through holes are provided in the middle of both the front baffle and the middle adhesive layer. The edge of the microneedle transdermal patch is attached to the middle adhesive layer, and the microneedle array of the microneedle transdermal patch penetrates through the first through holes. A second through hole is provided on the screw cap opposite to the microneedle array;

[0010] The rear baffle is in contact connection with the middle adhesive layer and the microneedle transdermal patch.

[0011] The auxiliary detection device for measuring the release rate of the microneedle transdermal patch of the present invention forms a cavity for accommodating the microneedle transdermal patch through the cooperation and assembly of the screw cap and the screw bottom, provides mechanical strength support through the front baffle, and provides a water sealing condition through the middle adhesive layer. The microneedles sequentially penetrate through the first through holes in the middle adhesive layer and the front baffle, and the needle tips face the screw cap. By providing a second through hole in the middle of the screw cap, the microneedles can be brought into contact with the release medium; the edge of the microneedle transdermal patch is closely attached to the middle adhesive layer to prevent the release medium from permeating to the other side of the microneedle transdermal patch. At the same time, the side of the microneedle transdermal patch without microneedles is pressed tightly by the rear baffle to further prevent the side of the microneedle transdermal patch without microneedles from coming into contact with the release medium and causing release on the side without microneedles.

[0012] The assembly method of the auxiliary detection device for measuring the release rate of the microneedle transdermal patch of the present invention is as follows: sequentially install the front baffle and the middle adhesive layer into the screw cap. Among them, the first through holes of the front baffle and the middle adhesive layer are arranged opposite and coincident. Insert the microneedles of the microneedle transdermal patch into the first through hole along the direction from the middle adhesive layer to the front baffle, with the needle tips facing the screw cap direction. Press the edge of the microneedle transdermal patch tightly against the middle adhesive layer, and then press the rear baffle tightly on the outside of the middle adhesive layer and the microneedle transdermal patch. Finally, screw the screw bottom and the screw cap together for assembly to obtain the auxiliary detection device for measuring the release rate of the microneedle transdermal patch, and place it in a dissolution tester to measure the drug release rate of the microneedles. The device of the present invention has a simple structure, is convenient to assemble, simulates the medication scenario, and realizes drug release in a single direction. Therefore, the measurement results are accurate and precise, can effectively reflect the quality of the microneedles, and provide guarantee for the research and standardization of microneedle products.

[0013] Furthermore, a thickened layer is provided in the area where the middle adhesive layer contacts the edge of the microneedle transdermal patch and in the area of the rear baffle opposite to this contact area. The thickened layers on the middle adhesive layer and the rear baffle cooperate to bite the microneedle transdermal patch, facilitating the fixation of the microneedle transdermal patch.

[0014] Furthermore, a sealing ring is provided between the screw cap and the front baffle. The sealing ring is preferably a rubber ring to achieve the seal between the screw cap and the front baffle.

[0015] Furthermore, the shape of the first through hole is selected from one of a circle, a square, a wing shape, an eye patch shape, a strip shape, a triangle, a trapezoid, a rhombus, etc., including but not limited to this, and can be adjusted according to the specific shape of the microneedles to facilitate the research on the release rate of different-shaped microneedles.

[0016] Furthermore, the materials of the front baffle and the rear baffle are selected from one of polyetheretherketone, polytetrafluoroethylene, and polyvinyl alcohol. The front baffle and the rear baffle are made of materials with chemical inertness, resistant to acid and alkali corrosion and wear, and do not decompose in the release medium within the range of 30°C - 40°C.

[0017] Furthermore, the material of the middle adhesive layer is silica gel.

[0018] Furthermore, several positioning columns are provided on the side of the front baffle close to the middle adhesive layer, and positioning grooves are provided on the middle adhesive layer and the rear baffle opposite to the positioning columns. During assembly, the positioning columns are inserted into the positioning grooves, which can facilitate the positioning among the three, and at the same time, prevent the relative rotational movement between the front baffle inside and the middle adhesive layer and the microneedle transdermal patch fixed on the middle adhesive layer when the screw cap and the screw bottom are screwed and assembled.

[0019] Furthermore, the first through hole in the front baffle and the middle adhesive layer is consistent with the shape of the microneedle array in the microneedle transdermal patch, and is arranged opposite and coincident.

[0020] Further, the shape of the second through hole is circular, and the projection area of the first through hole on the screw cap is located within the second through hole.

[0021] Further, the screw cap is provided with internal threads, and the screw bottom is provided with external threads, and the two are assembled and connected through the internal and external threads.

[0022] Advantages of the present invention:

[0023] In the present invention, a cavity for accommodating the microneedle transdermal patch is formed by the cooperation and assembly of the screw cap and the screw bottom. The front baffle provides mechanical strength support, and the middle adhesive layer provides a water sealing condition. The microneedles penetrate into the first through holes in the middle adhesive layer and the front baffle in sequence with the needle tips facing the screw cap. By providing a second through hole in the middle of the screw cap, contact between the microneedles and the release medium can be achieved. The edge of the microneedle transdermal patch is closely attached to the middle adhesive layer to prevent the release medium from penetrating to the other side of the microneedle transdermal patch. At the same time, the side of the microneedle transdermal patch without microneedles is pressed tightly by the rear baffle, further avoiding contact between the side of the microneedle transdermal patch without microneedles and the release medium, which may cause release on the side without microneedles.

[0024] In the present invention, the middle adhesive layer and the thickened layer on the rear baffle cooperate to bite the microneedle transdermal patch, which is convenient for fixing the microneedle transdermal patch. At the same time, through the cooperation of the positioning posts on the front baffle and the positioning grooves on the middle adhesive layer, relative rotational movement between the internal front baffle, the middle adhesive layer, and the microneedle transdermal patch fixed on the middle adhesive layer during the screwing and assembling of the screw cap and the screw bottom is avoided, further preventing the movement of the microneedles within the first through holes.

[0025] The device of the present invention has a simple structure, is convenient to assemble, and simulates the medication scenario, achieving unidirectional drug release. Therefore, the measurement results are accurate and precise, which can effectively reflect the quality of the microneedles and provide guarantee for the research and standardization of microneedle products. Description of the Drawings

[0026] In order to more clearly illustrate the technical solutions of the present invention, the drawings required for use in the embodiments will be briefly introduced below. Obviously, the drawings in the following description are only embodiments of the present invention. For those of ordinary skill in the art, other drawings can be obtained based on these drawings without creative efforts.

[0027] Figure 1 is an exploded schematic view of the auxiliary detection device for measuring the release rate of the microneedle transdermal patch of the present invention;

[0028] Figure 2 is a sectional view of the auxiliary detection device for measuring the release rate of the microneedle transdermal patch of the present invention;

[0029] Figure 3 is a schematic view of the screw cap structure of the present invention;

[0030] Figure 4 It is a schematic diagram of the screw bottom structure of the present invention;

[0031] Figure 5 It is a schematic diagram of the front baffle structure with a square first through hole of the present invention;

[0032] Figure 6 It is a schematic diagram of the middle front baffle structure with a circular first through hole of the present invention;

[0033] Figure 7 It is a schematic diagram of the front baffle structure with an eye patch-shaped first through hole of the present invention;

[0034] Figure 8 It is the cumulative release curve of the drug release rate measured by the paddle method for the microneedle transdermal patch;

[0035] Figure 9 It is the cumulative release curve of the drug release rate measured by the auxiliary test device of the present invention in cooperation with a dissolution tester for the microneedle transdermal patch;

[0036] Explanation of the reference numerals in the figure: 1. Screw cap, 2. Screw bottom, 3. Front baffle, 4. Middle adhesive layer, 5. Rear baffle, 6. First through hole, 7. Microneedle transdermal patch, 8. Second through hole, 9. Thickened layer, 10. Positioning post, 11. Sealing ring. Detailed implementation manners

[0037] Next, the technical solution of the present invention will be clearly and completely described in conjunction with the specific embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without making creative efforts belong to the scope of protection of the present invention.

[0038] In the present invention, unless otherwise specified, the orientation or positional relationship indicated by the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc. used in the present invention is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be construed as a limitation to the present invention; the terms "first", "second", "third" are only used for descriptive purposes and cannot be construed as indicating or implying relative importance; in addition, unless otherwise clearly defined and limited, the terms "installed", "connected", "connected" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection, an electrical connection; it can be directly connected, or indirectly connected through an intermediate medium, and it can be the communication inside two elements. For those of ordinary skill in the art, the specific meanings of the above terms in this patent can be understood according to specific circumstances.

[0039] This embodiment provides an auxiliary detection device for measuring the release rate of a microneedle transdermal patch, with reference to Figures 1-4 As shown, it includes a screw cap 1 and a screw base 2. The screw cap 1 and the screw base 2 are assembled and connected by threads. After the screw cap 1 and the screw base 2 are assembled, a cavity is formed. Inside the cavity, a front baffle 3, a middle adhesive layer 4, and a rear baffle 5 are sequentially stacked in the direction from the screw cap 1 to the screw base 2. First through holes 6 are provided in the middle of both the front baffle 3 and the middle adhesive layer 4. With reference to Figures 5-7 , the edge of the microneedle transdermal patch 7 is attached to the middle adhesive layer 4, and the microneedle array of the microneedle transdermal patch 7 penetrates through the first through hole 6. A second through hole 8 is provided on the screw cap 1 opposite to the microneedle array. The rear baffle 5 is in contact connection with the middle adhesive layer 4 and the microneedle transdermal patch 7. The auxiliary device for measuring the release rate of the microneedle transdermal patch 7 in this embodiment forms a cavity for accommodating the microneedle transdermal patch 7 through the cooperation and assembly of the screw cap 1 and the screw base 2, provides mechanical strength support through the front baffle 3, and provides a water sealing condition through the middle adhesive layer 4. The microneedles sequentially penetrate into the first through holes 6 in the middle adhesive layer 4 and the front baffle 3, and the needle tips face the screw cap 1. By providing a second through hole 8 in the middle of the screw cap 1, contact between the microneedles and the release medium can be achieved. The edge of the microneedle transdermal patch 7 is closely attached to the middle adhesive layer 4 to prevent the release medium from permeating to the other side of the microneedle transdermal patch 7. At the same time, the side of the microneedle transdermal patch 7 without microneedles is pressed tightly by the rear baffle 5 to further prevent the side of the microneedle transdermal patch 7 without microneedles from coming into contact with the release medium and causing release on the side without microneedles.

[0040] The assembly method of the auxiliary detection device for measuring the release rate of the microneedle transdermal patch in this embodiment is as follows: The front baffle 3 and the middle adhesive layer 4 are sequentially inserted into the screw cap 1. Among them, the first through holes 6 of the front baffle 3 and the middle adhesive layer 4 are set to coincide exactly. The microneedles of the microneedle transdermal patch 7 are inserted into the first through hole 6 in the direction from the middle adhesive layer 4 to the front baffle 3, with the needle tips facing the screw cap 1 direction. The edge of the microneedle transdermal patch 7 is pressed and adhered tightly to the middle adhesive layer 4. Then, the rear baffle 5 is pressed tightly on the outside of the middle adhesive layer 4 and the microneedle transdermal patch 7. Finally, the screw base 2 is screwed tightly with the screw cap 1 to obtain the auxiliary detection device for measuring the release rate of the microneedle transdermal patch, which is placed in a dissolution tester to measure the drug release rate of the microneedles.

[0041] The auxiliary detection device for measuring the release rate of the microneedle transdermal patch in this embodiment has a simple structure, is convenient to assemble, and simulates the drug use scenario, realizing single-direction drug release. Therefore, the measurement results are accurate and precise, can effectively reflect the quality of the microneedles, and provide guarantee for the research and standardization of microneedle products.

[0042] As a preferred embodiment, the first through-hole 6 in the front baffle 3 and the middle adhesive layer 4 is consistent with the shape of the microneedle array in the microneedle transdermal patch 7, and they are arranged opposite and coincident; a thickened layer 9 is provided in the area where the middle adhesive layer 4 contacts the edge of the microneedle transdermal patch 7 and in the area of the rear baffle 5 opposite to this contact area. The thickened layers 9 on the middle adhesive layer 4 and the rear baffle 5 cooperate to bite the microneedle transdermal patch 7, facilitating the fixation of the microneedle transdermal patch 7. A number of positioning posts 10 are provided on the side of the front baffle 3 close to the middle adhesive layer 4. Positioning grooves are provided on the middle adhesive layer 4 and the rear baffle opposite to the positioning posts 10. When assembling, the positioning posts 10 are inserted into the positioning grooves, which can facilitate the positioning among the three. At the same time, it can prevent the relative rotational movement between the inner front baffle 3 and the middle adhesive layer 4 and the microneedle transdermal patch 7 fixed on the middle adhesive layer 4 when the screw cap 1 and the screw bottom 2 are screwed and assembled.

[0043] As a preferred embodiment, a sealing ring 11 is further provided between the screw cap 1 and the front baffle 3. The sealing ring 11 is preferably a rubber ring to achieve the seal between the screw cap 1 and the front baffle 3.

[0044] As a preferred embodiment, the materials of the front baffle 3 and the rear baffle 5 are selected from one of polyetheretherketone, polytetrafluoroethylene, and polyvinyl alcohol. The front baffle 3 and the rear baffle 5 are made of materials with chemical inertness, resistant to acid and alkali corrosion and wear, and do not decompose in the release medium within the range of 30°C - 40°C. The material of the middle adhesive layer 4 is silica gel.

[0045] As a preferred embodiment, referring to Figures 5-7 , the shape of the first through-hole 6 is selected from one of a circle, a square, a wing shape, an eye patch shape, a strip shape, a triangle, a trapezoid, a rhombus, etc., including but not limited to this, and can be adjusted according to the specific shape of the microneedles to facilitate the study of the release degree of different-shaped microneedles. The shape of the second through-hole 8 is a circle, and the projection area of the first through-hole 6 on the screw cap 1 is located within the second through-hole 8.

[0046] As a preferred embodiment, the screw cap 1 is provided with an internal thread, and the screw bottom 2 is provided with an external thread, and the two are assembled and connected through the internal thread and the external thread.

[0047] Test example

[0048] Place the auxiliary device loaded with the microneedle transdermal patch in a dissolution tester to measure the drug release degree, and compare it with the result of measuring the drug release degree of this microneedle transdermal patch by the paddle-disk method, referring to Figure 8 and Figure 9When the paddle - disk method is used to determine the drug release rate of the microneedle transdermal patch, the cumulative release amount and release rate at the same time point are both greater than the measurement results obtained using the device of the present invention. If the results of the paddle - disk method are used to guide the formulation process development, an incorrect conclusion that the drug can be rapidly released in a short time will inevitably be drawn. The reason is that the microneedles are in full contact with the medium, and the drug can be released without hindrance on the front side (the side with microneedles), the back side (the side without microneedles), and the side of the microneedle transdermal patch. This does not conform to the clinical drug - using scenario and cannot reflect the actual drug release situation and the quality of the microneedles. When using the device of the present invention, only the side with the microneedle array can release the drug. The detection result of the release rate is about half of that of the paddle - disk method, which truly reflects the actual drug release situation of the drug. This result can correctly guide clinical drug use, process optimization, and provide a basis for the quality control of microneedles.

[0049] In summary, in the present invention, the screw cap and the screw bottom are assembled in cooperation to form a cavity for accommodating the microneedle transdermal patch. The front baffle provides mechanical strength support, and the middle adhesive layer provides a water - sealing condition. The microneedles penetrate through the first through - holes in the middle adhesive layer and the front baffle in sequence with the needle tips facing the screw cap. By setting the second through - hole in the middle of the screw cap, the contact between the microneedles and the release medium can be achieved; the edge of the microneedle transdermal patch is closely attached to the middle adhesive layer to prevent the release medium from permeating to the other side of the microneedle transdermal patch. At the same time, the side of the microneedle transdermal patch without microneedles is pressed tightly by the rear baffle to further avoid the contact between the side of the microneedle transdermal patch without microneedles and the release medium, which may cause the release on the side without microneedles; the middle adhesive layer and the thickened layer on the rear baffle cooperate to bite the microneedle transdermal patch, which is convenient for fixing the microneedle transdermal patch. At the same time, through the cooperation of the positioning posts on the front baffle and the positioning grooves on the middle adhesive layer, the relative rotational movement between the internal front baffle, the middle adhesive layer, and the microneedle transdermal patch fixed on the middle adhesive layer during the screwing and assembling of the screw cap and the screw bottom is avoided, further preventing the movement of the microneedles in the first through - holes. The device has a simple structure, is convenient to assemble, and simulates the drug - using scenario, realizing single - direction drug release. Therefore, the measurement results are accurate and precise, can effectively reflect the quality of the microneedles, and provide a guarantee for the research and standardization of microneedle products.

[0050] The present invention has been described in detail above in combination with specific embodiments and exemplary examples, but these descriptions should not be construed as limiting the present invention. Those skilled in the art understand that without departing from the spirit and scope of the present invention, various equivalent substitutions, modifications, or improvements can be made to the technical solutions and their implementation manners of the present invention, and all of these fall within the scope of the present invention. The protection scope of the present invention is subject to the appended claims.

Claims

1. An auxiliary detection device for measuring the release rate of a microneedle transdermal patch, characterized in that It includes a screw cap and a screw bottom. The screw cap and the screw bottom are assembled and connected by threads. After the screw cap and the screw bottom are assembled, a cavity is formed. A front baffle, a middle adhesive layer, and a rear baffle are sequentially stacked in the cavity in the direction from the screw cap to the screw bottom. First through holes are provided in the middle of both the front baffle and the middle adhesive layer. The edge of the microneedle transdermal patch is attached to the middle adhesive layer, and the microneedle array of the microneedle transdermal patch penetrates through the first through holes. A second through hole is provided in the screw cap opposite to the microneedle array. The rear baffle is in contact connection with the middle adhesive layer and the microneedle transdermal patch.

2. The auxiliary detection device for measuring the release rate of the microneedle transdermal patch according to claim 1, wherein, A thickened layer is provided in a circular shape in the area where the middle adhesive layer is in contact with the edge of the microneedle transdermal patch and in the area of the rear baffle opposite to this contact area.

3. The auxiliary detection device for measuring the release rate of the microneedle transdermal patch according to claim 1, wherein A number of positioning posts are provided on the side of the front baffle close to the middle adhesive layer, and positioning grooves are provided on the middle adhesive layer and the rear baffle opposite to the positioning posts.

4. The auxiliary detection device for measuring the release rate of the microneedle transdermal patch according to claim 1, characterized in that, A sealing ring is also provided between the screw cap and the front baffle.

5. The auxiliary detection device for determining the release rate of the microneedle transdermal patch according to claim 1, characterized in that, The shape of the first through hole is selected from one of a circle, a square, a wing shape, an eye patch shape, a strip shape, a triangle, a trapezoid, and a rhombus.

6. The auxiliary detection device for measuring the release rate of the microneedle transdermal patch according to claim 1, wherein, The materials of the front baffle and the rear baffle are selected from one of polyetheretherketone, polytetrafluoroethylene, and polyvinyl alcohol.

7. The auxiliary detection device for measuring the release rate of the microneedle transdermal patch according to claim 1, characterized in that, The material of the middle adhesive layer is silica gel.

8. The auxiliary detection device for measuring the release rate of the microneedle transdermal patch according to claim 1, wherein, The first through holes in the front baffle and the middle adhesive layer are consistent with the shape of the microneedle array in the microneedle transdermal patch and are arranged opposite and coincidentally.

9. The auxiliary detection device for measuring the release rate of the microneedle transdermal patch according to claim 1, wherein, The shape of the second through hole is circular, and the projection area of the first through hole on the screw cap is located within the second through hole.

10. The auxiliary detection device for determining the release rate of the microneedle transdermal patch according to claim 1, wherein, The screw cap is provided with an internal thread, and the screw bottom is provided with an external thread. The two are assembled and connected through the internal thread and the external thread.

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