Preparation method of herbaceous plant for conditioning diabetes

Abstract

The invention relates to the technical field of preparation of traditional Chinese medicine preparations, in particular to a preparation method of a herbaceous plant for conditioning diabetes mellitus, and the herbaceous plant is prepared from 200g of folium mori, 300g of bitter gourd, 150g of black fungus, 150g of radix angelicae pubescentis, 150g of radix paeoniae rubra, 300g of radix astragali, 200g of rhizoma atractylodis macrocephalae, 200g of poria cocos, 60g of ginseng, 200g of radix salviae miltiorrhizae, 200g of fructus gardeniae, 150g of American ginseng and 120g of radix notoginseng. Effective components of all plants can be reserved to the maximum extent, meanwhile, various medicinal material components are mutually compatible, radix astragali has the effects of tonifying qi and lifting yang, rhizoma atractylodis macrocephalae has the effects of tonifying spleen and eliminating dampness, poria cocos has the effects of clearing damp and promoting diuresis and the like, and tonifying products such as ginseng and American ginseng are matched and have a synergistic effect with blood glucose reducing components such as bitter gourd and folium mori; the diabetes is comprehensively conditioned from multiple aspects of regulating body metabolism, enhancing immunity, improving pancreas islet functions and the like, and the overall drug effect is improved.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine preparation, and specifically to a preparation method of herbal plants for regulating diabetes insipidus. Background Art

[0002] Diabetes insipidus, corresponding to diabetes mellitus and its related metabolic diseases in modern medicine, is a chronic disease characterized by hyperglycemia, which seriously threatens human health. With the change of lifestyle and the aggravation of population aging, the number of global diabetes patients shows an increasing trend year by year. According to the statistics of the International Diabetes Federation (IDF), currently, hundreds of millions of people around the world are troubled by diabetes, and this disease can cause various complications such as cardiovascular and cerebrovascular diseases, kidney lesions, and retinopathy, significantly reducing the quality of life of patients and increasing the social medical burden.

[0003] At present, modern medicine for treating diabetes mainly relies on chemical drugs (such as metformin, insulin secretagogues, etc.) and insulin injection. Although it can effectively control blood sugar, long-term use has side effects such as hypoglycemia risk, liver and kidney toxicity, and gastrointestinal discomfort. Some patients will also develop drug tolerance, resulting in a decline in efficacy. In contrast, traditional Chinese medicine has a long history in regulating diabetes insipidus and has the advantages of multi-target and overall regulation, and can play an important role in improving clinical symptoms, delaying the progression of complications, and reducing the side effects of western medicine. Summary of the Invention

[0004] The purpose of the present invention is to provide a preparation method of herbal plants for regulating diabetes insipidus to solve the problems raised in the above background art.

[0005] The technical solution of the present invention is: a preparation method of herbal plants for regulating diabetes insipidus, including 200 g of mulberry leaves, 300 g of balsam pears, 150 g of black fungus, 150 g of angelica pubescens, 150 g of red peonies, 300 g of astragalus membranaceus, 200 g of atractylodes macrocephala, 200 g of poria cocos, 60 g of ginseng, 200 g of salvia miltiorrhiza, 200 g of gardenia jasminoides, 150 g of American ginseng, 120 g of notoginseng, 200 g of lotus leaves, 200 g of wax gourd peel, 300 g of chicken gizzards, 200 g of schisandra chinensis, 150 g of phellodendron amurense, 200 g of alisma orientale, 150 g of cuscuta chinensis, 120 g of eucommia ulmoides, 150 g of ground bitter gall, 202 g of apricot kernels, 150 g of ligusticum wallichii, 120 g of raw licorice, 1000 g of honey, and 4000 g of white wine, and includes the following preparation steps: Step S1: Wash the mulberry leaves, dry them in a drying oven at 60 - 70 °C until the water content is lower than 8%, and then crush the mulberry leaves to 200 - 300 meshes to obtain mulberry leaf powder for standby; Step S2: Wash the balsam pear, remove the seeds, cut it into thin slices, perform vacuum freeze-drying at 50 - 60 °C, and then crush it into a powder of 100 - 150 meshes to obtain balsam pear powder for standby; Step S3: After the black fungus is soaked and washed, it is steamed in steam at 80 - 90 °C for 20 - 30 minutes, then dried at 55 - 65 °C, and then crushed into particles of 80 - 120 mesh to obtain black fungus powder for standby; Step S4: Wash Duhuo, Red Peony Root, Astragalus membranaceus, Atractylodes macrocephala, Poria cocos, Salvia miltiorrhiza, Gardenia jasminoides, American Ginseng, Notoginseng, Lotus Leaf, Wax Gourd Peel, Chicken Gizzard-membrane, Schisandra chinensis, Phellodendron amurense, Alisma orientale, Cuscuta chinensis, Eucommia ulmoides, Bitter Coptis Rhizome, Ligusticum wallichii, and Licorice Root, dry them in the air, and then perform reflux extraction with 70% - 80% ethanol for 2 - 3 times. The extraction time for each time is 1.5 - 2.5 hours. Combine the extraction liquids, concentrate them under reduced pressure to an extract with a relative density of 1.1 - 1.3 (60 °C), dry it, and then crush it into a powder of 100 - 150 mesh to obtain a mixed powder for standby; Step S5: Cut the ginseng into slices and extract it by the water extraction and alcohol precipitation method. First, decoct it with water for 2 - 3 times, 1 - 2 hours each time. Combine the decoction liquids, concentrate them, add ethanol to make the alcohol content reach 60% - 70%, let it stand overnight, filter, and concentrate the filtrate under reduced pressure into an extract. Dry it and then crush it into a powder of 100 - 150 mesh to obtain ginseng powder for standby; Step S6: Remove the skin of the almonds and extract almond oil by the pressing method for standby. Then crush the remaining residue into a powder of 100 - 150 mesh to obtain almond powder for standby; Step S7: Add mulberry leaf powder, balsam pear powder, black fungus powder, mixed powder, and almond powder to honey and stir evenly. Slowly add white liquor (500g - 1000g - 2500g) in 3 times. After adding white liquor each time, stir well for 5 - 10 minutes to ensure that the materials are mixed evenly to form a uniform mixed liquid. Seal the mixed liquid and soak it at 20 - 25 °C for 30 - 45 days. Stir it once every 5 - 7 days during the soaking process; Step S8: After the soaking is completed, use a plate and frame filter press with a 200 - mesh filter cloth for filtration to remove the residue, obtaining a combined medicinal liquid of herbal plants for regulating diabetes. The pressure for concentration under reduced pressure is -0.06 - -0.08 MPa, and the temperature is 50 - 60 °C. Add an appropriate amount of starch as an excipient, mix evenly to form a soft material, extrude the soft material through a pill-making machine into a pill bar with a diameter of 5 - 8 mm, and then cut it into uniform pills. Place the pills in a drying oven at 50 - 60 °C and dry them until the water content is less than 9% to obtain herbal pills for diabetes.

[0006] Preferably, the white liquor is a high - degree white liquor brewed from pure grain, and the alcohol content is 52 - 55 degrees.

[0007] Preferably, when extracting ginseng by the water extraction and alcohol precipitation method, the water addition amount for the first decoction is 8 - 10 times the mass of the medicinal materials, and the water addition amount for the second decoction is 6 - 8 times the mass of the medicinal materials.

[0008] Preferably, the particle size distribution of the mixed powder needs to be detected to ensure that more than 95% of the particles meet the standard of 100 - 150 mesh.

[0009] Preferably, after the almonds are pressed to extract oil, the residue needs to be dried at 40°C for 2 hours and then crushed.

[0010] Preferably, when performing ethanol reflux extraction, the medicinal materials need to be soaked in ethanol for 30 minutes before each extraction.

[0011] Preferably, the combined herbal medicine solution needs to be subjected to secondary sterilization treatment and filtered using a microporous membrane with a pore size of 0.22 μm.

[0012] Preferably, the honey is sophora flower honey, and the Baumé degree of the sophora flower honey is not less than 42 degrees.

[0013] The present invention provides an improved preparation method of herbal plants for conditioning diabetes insipidus. Compared with the prior art, it has the following improvements and advantages: Firstly: In the present invention, by adopting targeted treatment and extraction methods for different herbal plants, such as drying and crushing mulberry leaves, vacuum freeze-drying bitter gourds, steaming and drying black fungus, etc., the active ingredients of each plant can be retained to the greatest extent. At the same time, the components of various medicinal materials are mutually compatible. Astragalus membranaceus can invigorate qi and promote yang, Atractylodes macrocephala can strengthen the spleen and dry dampness, Poria cocos can promote diuresis and percolate dampness, etc. In combination with tonics such as ginseng and American ginseng, and synergistically acting with hypoglycemic components such as bitter gourd and mulberry leaves, it comprehensively conditions diabetes insipidus from multiple aspects such as regulating body metabolism, enhancing immunity, and improving islet function, thus enhancing the overall medicinal effect.

[0014] Secondly: In the present invention, during the preparation process, strict control is carried out on key links, such as the selection of liquor degree, the control of the amount of water added in water extraction and alcohol precipitation, the detection of powder particle size, the sterilization treatment of the medicinal liquid, etc. 52 - 55-degree liquor brewed from pure grains is beneficial to the leaching and preservation of active ingredients; the precise amount of water added in water extraction and alcohol precipitation ensures the full extraction of medicinal materials components; strict particle size detection and sterilization treatment ensure the uniformity, stability and safety of the product, enabling each batch of products to maintain a high quality standard and ensuring the consistency of product efficacy.

[0015] Thirdly: In the present invention, the finally prepared pill dosage form is convenient for carrying and taking, and is suitable for long-term conditioning use by patients. During the preparation process, through processes such as vacuum concentration and adding starch excipients, the pills are well formed and the water content is properly controlled. This not only ensures the content of the active ingredients of the medicine, but also is convenient for storage. At the same time, soaking in liquor and subsequent treatment enable the herbal plant components to be fully integrated. The prepared pills can slowly release the medicinal effect in the human body, extend the action time, improve the bioavailability of the medicine, and thus more effectively play the role of conditioning diabetes insipidus. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] The following further explains the present invention in conjunction with the drawings and embodiments: Figure 1 It is a schematic diagram of the production process of the present invention; Figure 2 is a schematic diagram of the processing technology of the present invention; Figure 3 is a schematic diagram of the detection method of the present invention. Specific Embodiments

[0017] The present invention will be described in detail below. The technical solutions in the embodiments of the present invention are clearly and completely described. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

[0018] The present invention provides a preparation method of herbal plants for regulating diabetes insipidus by improvement. The technical solution of the present invention is as follows: As Figure 1 - Figure 3 shown, a preparation method of herbal plants for regulating diabetes insipidus includes 200 g of mulberry leaves, 300 g of balsam pears, 150 g of black fungus, 150 g of angelica pubescens, 150 g of red peonies, 300 g of astragalus membranaceus, 200 g of atractylodes macrocephala, 200 g of poria cocos, 60 g of ginseng, 200 g of salvia miltiorrhiza, 200 g of gardenia jasminoides, 150 g of American ginseng, 120 g of notoginseng, 200 g of lotus leaves, 200 g of wax gourd peels, 300 g of chicken gizzards, 200 g of schisandra chinensis, 150 g of phellodendron amurense, 200 g of alisma orientale, 150 g of cuscuta chinensis, 120 g of eucommia ulmoides, 150 g of ground bitter gall, 202 g of apricot kernels, 150 g of ligusticum wallichii, 120 g of raw licorice, 1000 g of honey, and 4000 g of white liquor, and includes the following preparation steps: Step S1: Wash the mulberry leaves, dry them in a drying oven at 60-70 °C until the water content is lower than 8%, and then crush the mulberry leaves to 200-300 meshes to obtain mulberry leaf powder for standby; Step S2: Wash the balsam pear, remove the seeds, cut it into thin slices, perform vacuum freeze-drying at 50-60 °C, and then crush it into a powder of 100-150 meshes to obtain balsam pear powder for standby; Step S3: After soaking and washing the black fungus, steam it in steam at 80-90 °C for 20-30 minutes, then dry it at 55-65 °C, and then crush it into particles of 80-120 meshes to obtain black fungus powder for standby; Step S4: Wash angelica pubescens, red peony, astragalus membranaceus, atractylodes macrocephala, poria cocos, salvia miltiorrhiza, gardenia jasminoides, American ginseng, notoginseng, lotus leaf, wax gourd peel, chicken gizzard, schisandra chinensis, phellodendron amurense, alisma orientale, cuscuta chinensis, eucommia ulmoides, ground bitter gall, ligusticum wallichii, and raw licorice, dry them, and then perform reflux extraction with 70%-80% ethanol for 2-3 times, with each extraction time being 1.5-2.5 hours. Combine the extraction solutions, concentrate them under reduced pressure to an extract with a relative density of 1.1-1.3 (60 °C), dry it, and then crush it into a powder of 100-150 meshes to obtain a mixed powder for standby; Step S5: Slice the ginseng and extract it by the method of water extraction and alcohol precipitation. First, decoct it with water 2 - 3 times, 1 - 2 hours each time. Combine the decoction liquids, concentrate them, and then add ethanol to make the alcohol content reach 60% - 70%. Let it stand overnight, filter, concentrate the filtrate under reduced pressure into an extract, dry it, and then pulverize it into a powder of 100 - 150 mesh. Reserve the ginseng powder. Step S6: Remove the skins of the almonds and extract almond oil by the pressing method for reserve. Then pulverize the remaining residue into a powder of 100 - 150 mesh. Reserve the almond powder. Step S7: Add mulberry leaf powder, balsam pear powder, black fungus powder, the mixed powder, and almond powder into honey and stir evenly. Slowly add white liquor (500g - 1000g - 2500g) in 3 times. After adding the white liquor each time, stir well for 5 - 10 minutes to ensure the materials are evenly mixed, forming a uniform mixed liquid. Seal the mixed liquid and soak it at 20 - 25°C for 30 - 45 days. Stir it once every 5 - 7 days during the soaking process. Step S8: After the soaking is completed, filter it with a plate and frame filter press equipped with a 200 - mesh filter cloth to remove the residue, obtaining the herbal plant combination liquid for regulating diabetes mellitus. The pressure for reduced pressure concentration is -0.06 - -0.08 MPa, and the temperature is 50 - 60°C. Add an appropriate amount of starch as an excipient, mix evenly to make a soft material, extrude the soft material through a pill making machine into a pill strip with a diameter of 5 - 8 mm, and then cut it into uniform pills. Place the pills in a drying oven at 50 - 60°C and dry them until the water content is lower than 9%, obtaining the herbal plant pills for diabetes mellitus.

[0019] Furthermore, the white liquor is high - degree white liquor brewed from pure grains, with an alcohol content of 52 - 55 degrees. The high - degree white liquor brewed from pure grains plays an important role in the whole preparation process. Select high - quality grains such as sorghum, wheat, and corn as raw materials, and brew them through traditional processes such as steaming, fermentation, and distillation without adding any artificially synthesized spices, alcohol and other components, and the alcohol content is between 52 - 55 degrees. Such an alcohol content can not only effectively dissolve the active ingredients in the herbal plants and promote the leaching of various active substances in the medicinal materials, but also play a role in anti - corrosion and preservation of the medicinal effect to a certain extent. At the same time, the white liquor with such an alcohol content has a mellow taste. After being mixed with other components, it can make the final product achieve a better balance in taste and efficacy. When selecting white liquor, attention should be paid to checking the production standards and raw material components of the product to ensure that it meets the requirements of pure - grain brewing, so as to ensure the quality and safety of the finally prepared herbal plant product for regulating diabetes mellitus.

[0020] Furthermore, when extracting ginseng by the water extraction and alcohol precipitation method, the water addition amount for the first decoction is 8 - 10 times the mass of the medicinal materials, and the water addition amount for the second decoction is 6 - 8 times the mass of the medicinal materials. During the process of extracting ginseng by the water extraction and alcohol precipitation method, reasonably controlling the water addition amount is the key to ensuring the full extraction of the effective components of ginseng. The water addition amount for the first decoction being 8 - 10 times the mass of the medicinal materials, sufficient water can fully soak and heat the medicinal materials, prompting water-soluble components such as polysaccharides and saponins to dissolve into the water to the greatest extent. The water addition amount for the second decoction is 6 - 8 times the mass of the medicinal materials. At this time, some of the remaining effective components in the medicinal materials can still dissolve out in an appropriate amount of water. This way of decocting with two different water addition amounts not only ensures the extraction rate of the effective components but also avoids the problems of increased energy consumption and extended time in the subsequent concentration process due to excessive water. At the same time, during the decoction process, attention should be paid to controlling the heat and time to maintain uniform heating to ensure the same effect for each decoction, thereby improving the stability and reliability of ginseng extraction and laying a foundation for the subsequent production of high-quality herbal products for regulating diabetes mellitus.

[0021] Furthermore, the mixed powder needs to be subjected to particle size distribution detection to ensure that more than 95% of the particles meet the standard of 100 - 150 mesh. Conducting particle size distribution detection on the mixed powder is of great significance. The particle size standard of 100 - 150 mesh can ensure good uniformity when various herbal components are mixed with other raw materials subsequently. If the particles are too large, it may be difficult to disperse evenly when mixed with honey, liquor, etc., affecting the quality of the final product and the efficacy. If the particles are too fine, it may increase the surface area of the powder, making it more likely to absorb moisture and caking during storage, affecting the stability and shelf life of the product. By strictly detecting the particle size distribution to ensure that more than 95% of the particles meet the standard, it can ensure that the mixed powder has a uniform texture and accurate dosage when made into pills subsequently, and patients can better absorb the drug components after taking them, thereby enhancing the effect of regulating diabetes mellitus. In addition, the particle size distribution detection can also be used as a quality monitoring indicator during the production process to promptly discover and solve possible comminution process problems during production, ensuring the consistency and stability of product quality.

[0022] Further, after the almond oil is extracted by pressing, the residue needs to be dried at 40°C for 2 hours before being pulverized. After the almond oil is extracted by pressing, the residue still contains a certain amount of active ingredients and some moisture. Drying the residue at 40°C for 2 hours is a relatively scientific and reasonable temperature and time setting. The temperature of 40°C is neither too high to cause the active ingredients in the residue to decompose or denature due to heat, nor can it effectively remove the moisture in the residue. Appropriate drying treatment can reduce the water content of the residue, making it easier to operate in the subsequent pulverization process, and avoiding problems such as clogging of the pulverization equipment or caking of the pulverized powder due to excessive moisture. At the same time, the dried residue is pulverized into a powder of 100-150 mesh, which can better mix evenly with other herbal plant powders, and give full play to the role of the remaining active ingredients in the almond residue in regulating diabetes. In addition, the standardized drying and pulverization processes can also ensure the stability of the product quality, ensuring that the content and quality of the almond components in each batch of products are consistent, thereby improving the overall quality and efficacy of the product.

[0023] Further, when performing ethanol reflux extraction, the medicinal materials need to be soaked in ethanol for 30 minutes before each extraction. Soaking the medicinal materials in ethanol for 30 minutes before ethanol reflux extraction of the medicinal materials is an important pretreatment step. During the soaking process, ethanol can fully penetrate into the cell tissues inside the medicinal materials, soften the cell walls of the medicinal materials, and destroy the cell structure, creating good conditions for the dissolution of active ingredients during subsequent reflux extraction. After 30 minutes of soaking, active ingredients such as alkaloids and flavonoids in the medicinal materials can come into full contact with ethanol and are more easily extracted during the reflux extraction process, thereby increasing the extraction rate of active ingredients. In addition, soaking can also initially dissolve some easily soluble components of the medicinal materials in ethanol, reducing the reflux extraction time and energy consumption. At the same time, during the soaking process, attention should be paid to maintaining the cleanliness and sealing of the environment to avoid ethanol volatilization and contamination by external impurities, so as to ensure the quality and safety of the extraction. Through standardized soaking operations, it can be ensured that the ethanol reflux extraction process is more efficient and stable, providing a guarantee for obtaining high-quality mixed powder, and further improving the quality of the herbal plant product for regulating diabetes.

[0024] Furthermore, the herbal plant combined liquid medicine needs to be subjected to secondary sterilization treatment, which is filtered through a microporous membrane with a pore size of 0.22 μm. Secondary sterilization treatment of the herbal plant combined liquid medicine and filtration through a microporous membrane with a pore size of 0.22 μm are important steps to ensure the safety and quality of the product. The pore size of 0.22 μm can effectively intercept microorganisms such as bacteria, fungi, and yeasts, as well as some tiny impurity particles in the liquid medicine, enabling the liquid medicine to reach a high aseptic standard. Secondary sterilization treatment further reduces the risk of microbial contamination and extends the shelf life of the product, ensuring that patients will not experience adverse reactions caused by microbial contamination during the taking process. When performing microporous membrane filtration, it is necessary to strictly follow the operating procedures, select reliable filter membranes and filtration equipment to ensure the tightness and integrity of the filtration process. At the same time, the filtered liquid medicine also needs to be subjected to microbial detection to ensure compliance with relevant quality standards. In addition, secondary sterilization treatment not only improves the safety of the product but also can, to a certain extent, improve the clarity and stability of the liquid medicine, enhancing the appearance quality and internal quality of the product, making the finally prepared herbal plant pills for regulating diabetes more safe, effective, and reliable, and enhancing patients' trust and compliance with the product.

[0025] Furthermore, the honey is sophora flower honey, and the Baumé degree of the sophora flower honey is not less than 42 degrees. Selecting sophora flower honey with a Baumé degree not less than 42 degrees has a significant impact on the quality and efficacy of the herbal plant product for regulating diabetes. Sophora flower honey has unique properties. It has a sweet taste and a fragrant smell, and contains rich nutrients such as glucose, fructose, vitamins, and minerals. In the product, it not only plays a role in flavoring but also increases the viscosity of the product, helping to better mix various herbal plant powders and liquor together to form a uniform and stable system. Sophora flower honey with a Baumé degree not less than 42 degrees indicates that it has a low water content and a high sugar content, with good anti-corrosion properties, which can, to a certain extent, extend the shelf life of the product. At the same time, the active ingredients in sophora flower honey may also interact synergistically with other herbal plant ingredients to enhance the regulatory effect of the product on diabetes. When purchasing sophora flower honey, high-quality products from regular channels should be selected, and professional detection means should be used to ensure that its Baumé degree and quality meet the requirements. Also, pay attention to checking the production date, shelf life, and storage conditions of the sophora flower honey to avoid affecting the quality and efficacy of the entire product due to honey quality problems, thus ensuring that the finally prepared herbal plant pills for regulating diabetes have a good taste, stability, and curative effect.

[0026] The above description enables those skilled in the art to implement or use the present invention. Various modifications to these embodiments will be apparent to those skilled in the art, and the general principles defined herein can be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to these embodiments shown herein, but rather will be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A preparation method of a herbal plant for regulating diabetes insipidus, comprising 200 g of mulberry leaves, 300 g of balsam pears, 150 g of black fungus, 150 g of angelica pubescens, 150 g of red peonies, 300 g of astragalus membranaceus, 200 g of atractylodes macrocephala, 200 g of poria cocos, 60 g of ginseng, 200 g of salvia miltiorrhiza, 200 g of gardenia jasminoides, 150 g of american ginseng, 120 g of notoginseng, 200 g of lotus leaves, 200 g of wax gourd peel, 300 g of chicken gizzards, 200 g of schizandra chinensis, 150 g of phellodendron amurense, 200 g of alisma orientale, 150 g of cuscuta chinensis, 120 g of eucommia ulmoides, 150 g of picrorhiza scrophulariiflora, 202 g of apricot kernels, 150 g of ligusticum wallichii, 120 g of raw licorice root, 1000 g of honey, and 4000 g of white liquor, characterized in that: It includes the following preparation steps: Step S1: Wash the mulberry leaves, dry them in a drying oven at 60-70°C until the water content is less than 8%, and then crush the mulberry leaves to 200-300 mesh to obtain mulberry leaf powder for standby; Step S2: Wash the balsam pears, remove the seeds, cut them into thin slices, perform vacuum freeze-drying at 50-60°C, and then crush them into 100-150 mesh powder to obtain balsam pear powder for standby; Step S3: Soak and wash the black fungus, steam it in steam at 80-90°C for 20-30 minutes, then dry it at 55-65°C, and then crush it into 80-120 mesh particles to obtain black fungus powder for standby; Step S4: Wash the angelica pubescens, red peony root, astragalus membranaceus, atractylodes macrocephala, poria cocos, salvia miltiorrhiza, gardenia jasminoides, american ginseng, notoginseng, lotus leaf, wax gourd peel, chicken gizzard-membrane, schisandra chinensis, phellodendron amurense, alisma orientale, cuscuta chinensis, eucommia ulmoides, bitter gall of ground, ligusticum wallichii, and raw licorice root, dry them in the air, and then perform reflux extraction 2-3 times with 70%-80% ethanol. The extraction time for each time is 1.5-2.5 hours. Combine the extraction solutions, and concentrate them under reduced pressure to an extract with a relative density of 1.1-1.3 (60°C). After drying, crush it into 100-150 mesh powder to obtain mixed powder for standby; Step S5: Cut the ginseng into slices and extract it by the method of water extraction and alcohol precipitation. First, decoct it with water 2-3 times, 1-2 hours each time. Combine the decoction solutions, concentrate them, add ethanol to make the alcohol content reach 60%-70%, let it stand overnight, filter, and concentrate the filtrate under reduced pressure into an extract. After drying, crush it into 100-150 mesh powder for standby of ginseng powder; Step S6: Remove the skins of the almonds and extract almond oil by the pressing method for standby. Then crush the remaining residues into 100-150 mesh powder for standby of almond powder; Step S7: Add the mulberry leaf powder, balsam pear powder, black fungus powder, mixed powder, and almond powder to honey and stir evenly. Slowly add liquor (500g - 1000g - 2500g) in 3 times. After adding the liquor each time, stir well for 5-10 minutes to ensure uniform mixing of the materials and form a uniform mixture. Seal the mixture and soak it at 20-25°C for 30-45 days. Stir it once every 5-7 days during the soaking process; Step S8: After the soaking is completed, filter it with a plate and frame filter press equipped with a 200-mesh filter cloth to remove the residues, obtaining the herbal plant combination medicinal liquid for regulating diabetes. The pressure for reduced pressure concentration is -0.06--0.08MPa, and the temperature is 50-60°C. Add an appropriate amount of starch as an excipient, mix evenly to make a soft material, extrude the soft material through a pill-making machine into a pill bar with a diameter of 5-8mm, and then cut it into uniform pills. Place the pills in a drying oven at 50-60°C and dry them until the water content is less than 9% to obtain the herbal plant pills for diabetes.

2. The preparation method of a herbal plant for regulating diabetes according to claim 1, characterized in that: The liquor is a high-proof liquor brewed from pure grains, and the alcohol content is 52-55 degrees.

3. A preparation method of a herb for regulating diabetes according to claim 1, characterized in that: When extracting ginseng by the method of water extraction and alcohol precipitation, the amount of water added for the first decoction is 8-10 times the mass of the medicinal materials, and the amount of water added for the second decoction is 6-8 times the mass of the medicinal materials.

4. The preparation method of a herb for regulating diabetes according to claim 1, characterized in that: The mixed powder needs to be subjected to particle size distribution detection to ensure that more than 95% of the particles meet the 100-150 mesh standard.

5. The preparation method of a herb for regulating diabetes according to claim 1, characterized in that: After extracting oil from almonds, the residue needs to be dried at 40°C for 2 hours before being crushed.

6. The preparation method of a herb for regulating diabetes mellitus according to claim 1, wherein: When performing ethanol reflux extraction, the medicinal materials need to be soaked in ethanol for 30 minutes before each extraction.

7. A preparation method of a herb for regulating diabetes according to claim 1, characterized in that: The combined medicinal liquid of the herbal plants needs to be subjected to secondary sterilization treatment, and filtered using a microporous membrane with a pore size of 0.22 μm.

8. A preparation method of a herb for regulating diabetes mellitus according to claim 1, characterized in that: The honey is sophora flower honey, and the Baumé degree of the sophora flower honey is not less than 42 degrees.

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