Traditional Chinese medicine composition for treating precocious puberty (syndrome of downward flow of damp-heat) of children

Abstract

The invention discloses a traditional Chinese medicine composition for treating child sexual precocity (syndrome of downward flow of damp-heat), which belongs to the field of traditional Chinese medicines and is prepared from the following raw material medicines in parts by weight: radix bupleuri, patrinia, rhizoma smilacis glabrae, semen coicis, golden cypress, radix achyranthis bidentatae, radix gentianae, tortoise shell, selfheal, rhizoma anemarrhenae, rehmannia, lophatherum gracile, radix scrophulariae and liquorice. The traditional Chinese medicine composition adopts natural traditional Chinese medicines as raw materials, has definite curative effect and no toxic or side effect, can effectively treat damp-heat downward flow type pediatric precocious puberty, and promotes children to enter a benign growth and development cycle. After the medicine disclosed by the invention is clinically used and is incorporated into 110 patients according to statistics, the symptoms can be relieved and even disappear after the medicine is taken for 3-5 treatment courses. In the aspect of clinical effects, statistics shows that the cure rate is 89%, and the total effective rate reaches 98%.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and more specifically, it refers to a traditional Chinese medicine composition for treating precocious puberty (syndrome of damp-heat pouring downward) in children. Background Art

[0002] Precocious puberty refers to the appearance of secondary sexual characteristics in boys before the age of 9 and in girls before the age of 7.5. According to the pathogenesis and clinical manifestations, it is divided into central (gonadotropin-releasing hormone-dependent) precocious puberty and peripheral (non-gonadotropin-releasing hormone-dependent) precocious puberty. Among them, central precocious puberty (CPP) is the most common clinically.

[0003] It is reported that the global incidence of precocious puberty is about 0.2‰ to 1 / 10,000. In recent years, the incidence has increased significantly, and it has become one of the common pediatric endocrine diseases in clinical practice. Usually, the incidence in girls is higher, about 4.5 times that in boys. The clinical manifestations are premature puberty, premature appearance of secondary sexual characteristics. In boys, it shows the development of beard and sexual organs, and in girls, it shows breast development, menstruation, etc.

[0004] In traditional Chinese medical ancient books, there is no such disease name as "precocious puberty". Zhu Danxi believed that in children, "yang is often excessive and yin is often insufficient", so it is easy for "the ministerial fire to rise easily. When the five zang-organs of jueyin are fanned by the ministerial fire, they will move disorderly." The viscera of children are delicate and their form and qi are not fully developed, so they are of the constitution of immature yin and yang, with "the liver often being excessive and the kidney often being insufficient".

[0005] Therefore, traditional Chinese medicine believes that the main lesions of precocious puberty are in the liver and kidney. Physiologically, in children, the liver is often excessive, and the ministerial fire is easy to move disorderly; the kidney is often insufficient, and it is easy to have yin deficiency and fire hyperactivity. Therefore, the treatment mainly focuses on nourishing yin and reducing fire, and the legislative basis is to nourish the kidney yin and purge the ministerial fire.

[0006] Treatment from the liver. The liver governs dispersion and discharge, is the residence of the soul, the storage of blood, and the origin of tendons. It belongs to wood in the five elements, is in charge of ascending, and is in charge of movement. The liver stores blood, and the thoroughfare vessel is the sea of blood. The two are interconnected in the meridians. Women also rely on blood for their functions. When the liver blood is sufficient and the thoroughfare vessel is harmonious, a woman's menstruation will occur regularly.

[0007] Treatment from the kidney. The kidney stores essence, internally stores primordial yin and yang, is the congenital foundation, and is in charge of growth, development, and reproductive functions. Zhang Jingyue said in "Transmitting Loyalty Record · Supplementary Meaning of the Gate of Vitality": "The gate of vitality is the sea of essence and blood, and the spleen and stomach are the sea of water and grains. Both are the foundation of the five zang-organs and six fu-organs. However, the gate of vitality is the root of primordial qi, the dwelling place of water and fire. The yin qi and yang qi of the five zang-organs cannot be stimulated without it." The fire of the gate of vitality is rooted in the kidney water, and "the kidney is in charge of water, receiving the essence qi of the five zang-organs and six fu-organs and storing it".

[0008] According to "Pediatric Traditional Chinese Medicine" (5th Edition) (Xiong Lei. Pediatric Traditional Chinese Medicine [M]. Beijing: People's Medical Publishing House, 2024.) and "Clinical Diagnosis and Treatment Terms of Traditional Chinese Medicine Part 2: Syndromes" (GB / T 16751.2 - 2021, Clinical Diagnosis and Treatment Terms of Traditional Chinese Medicine, Part 2: Syndromes [S]), the syndrome of damp - heat pouring downward can be seen. That is, it is caused by the internal accumulation of damp - heat, which follows the meridian and pours downward, invading parts such as the bladder, intestine, uterus, genitals, anus or lower limbs. Clinically, there are symptoms such as distending pain in the abdomen, abdominal pain with resistance to pressure, frequent and urgent painful urination, or foul - smelling and loose stools, yellow and foul - smelling vaginal discharge, or eczema and itching in the anus and genitals, or ulceration and oozing of sores on the lower limbs, yellow - greasy tongue coating, and slippery or soggy and rapid pulse, etc.

[0009] To sum up, the existing treatment plans do not target precocious puberty in children with the syndrome of damp - heat pouring downward. To improve the deficiencies of the existing technology, in view of the characteristics of the above - mentioned syndrome type, the purpose of the present invention is to provide a traditional Chinese medicine composition for treating precocious puberty in children with the syndrome of damp - heat pouring downward. The formula is scientific and reasonable, the preparation method is simple, and it is convenient to use. The total clinical effective rate reaches 98%, and it has good economic and social benefits. Summary of the Invention

[0010] The purpose of this application of the present invention is to provide a traditional Chinese medicine composition for treating precocious puberty in children (syndrome of damp - heat pouring downward). The formula is rigorous, the compatibility is appropriate, and it hits the pathogenesis accurately. Each herb in the formula plays the roles of monarch, minister, assistant, and courier, treating both the symptoms and the root cause, and can effectively improve and treat precocious puberty in children with the syndrome of damp - heat pouring downward, showing significant curative effects clinically.

[0011] To solve the above - mentioned technical problems, the technical solution adopted by the present invention is as follows:

[0012] The present invention intends to provide a traditional Chinese medicine composition for treating precocious puberty in children (syndrome of damp - heat pouring downward), which relates to the technical field of traditional Chinese medicine. It includes the following Chinese medicinal materials: Bupleurum chinense, Patrinia scabiosaefolia, Smilax glabra, Coix lacryma - jobi, Phellodendron amurense, Achyranthes bidentata, Gentiana scabra, Testudinis carapax, Prunella vulgaris, Anemarrhena asphodeloides, Rehmannia glutinosa, Lophatherum gracile, Scrophularia ningpoensis, and Glycyrrhiza uralensis.

[0013] Compared with the prior art, this application has at least the following advantages or beneficial effects:

[0014] The effects of the medicinal materials used are as follows:

[0015] Bupleurum chinense: Pungent, bitter, slightly cold. It belongs to the liver, gallbladder, and lung meridians. Its effects are: dispersing wind - heat and relieving fever, soothing the liver and relieving depression, ascending yang - qi. Recorded in "Herbal Medicine for Prepared Use", Bupleurum chinense mainly treats the sinking of yang - qi, can lead the clear qi upward, and relieve the pathogenic heat of Shaoyang and Jueyin meridians. It promotes qi and blood circulation, dissipates stasis and regulates menstruation. Note by Wu Qian: People only know that Bupleurum chinense can induce sweating, but they don't know that Bupleurum chinense is most effective in regulating the interior. Therefore, it is often used in tonifying and blood - regulating herbs.

[0016] Patrinia scabiosaefolia: Pungent, bitter, slightly cold. It belongs to the stomach, large intestine, and liver meridians. Its effects are: clearing heat and detoxifying, eliminating carbuncles and discharging pus, removing stasis and relieving pain. This herb is pungent and dispersing, bitter and draining, cold and cooling. It can not only clear heat and detoxify but also eliminate carbuncles and discharge pus.

[0017] Glabrous Greenbrier Rhizome: sweet, light, neutral. It belongs to the liver and stomach meridians. Its effects are: detoxifying, removing dampness, clearing heat and detoxifying, dissipating swelling and nodules. This herb is sweet, light, and promoting diuresis, detoxifying and removing dampness. It is used to treat stranguria with turbid discharge, leukorrhea, scabies, eczema, and damp sores caused by damp-heat. The "Classic" says: Dampness harms people, affecting the skin, muscles, and tendons. Glabrous Greenbrier Rhizome is light and can promote diuresis, sweet and can tonify, and is mainly used to treat scrofula and sores. Recorded in "Compendium of Materia Medica from Yunnan", taking this herb alone by decocting in water can treat itching in the private parts, leukorrhea, and itching of the skin due to damp-heat.

[0018] Coix Seed: sweet, light, cool. It belongs to the spleen, stomach, and lung meridians. Its effects are: promoting diuresis and percolating dampness, strengthening the spleen and stopping diarrhea, dispelling impediment, discharging pus, and detoxifying and dissipating nodules. This herb clears the heat of the lung and intestine, discharges pus and eliminates carbuncles, and detoxifies and dissipates nodules.

[0019] Phellodendron Bark: bitter, cold. It belongs to the kidney and bladder meridians. Its effects are: clearing heat and drying dampness, purging fire and detoxifying, clearing away steaming bone. Danxi said: Ministerial fire is like the fire of heaven, the fire of dragon and thunder, and yin fire. It cannot be controlled by water and dampness. It should be subdued according to its nature. Only herbs like Phellodendron Bark can reduce it.

[0020] Achyranthes Root: bitter, sweet, sour. It belongs to the liver and kidney meridians. Its effects are: promoting blood circulation to remove stasis and relieve dysmenorrhea, tonifying the liver and kidney, strengthening the bones and muscles, promoting diuresis and relieving stranguria, guiding blood downward. Modern pharmacological research shows that Achyranthes Root and its active ingredients have the effects of contracting uterine smooth muscle, anti-implantation, and anti-early pregnancy on the reproductive system.

[0021] Gentiana Root: bitter, cold. It belongs to the liver and gallbladder meridians. Its effects are: clearing heat and drying dampness, purging the fire of the liver and gallbladder. This herb is bitter and cold. While clearing heat and drying dampness, it benefits the liver and gallbladder and purges fire, especially good at clearing dampness-heat in the lower jiao, and is commonly used to treat various syndromes caused by dampness-heat in the lower jiao. Modern pharmacological research shows that the Gentiana Root decoction can significantly inhibit the activity of steroid Δ4-reductase in hyperthyroid rats, suggesting that Gentiana Root can inhibit the inactivation of cortisol by the liver, proving the pharmacological effect of Gentiana Root in purging liver fire. It can inhibit the inactivation of cortisol by the liver, and the pharmacological experiment has a clear target for the treatment of hyperthyroidism.

[0022] Turtle Shell: salty, sweet, slightly cold. It belongs to the liver, kidney, and heart meridians. This herb is a product with rich nutrition and qi. It is salty, sweet, and slightly cold in nature. It can not only nourish the yin of the liver and kidney to reduce internal heat, but also subdue the liver yang to calm internal wind. It is used to treat yin deficiency with internal heat, hectic fever due to yin deficiency, night sweats, and spermatorrhea.

[0023] Selfheal Spike Sedge Herb: pungent, bitter, cold. It belongs to the liver and gallbladder meridians. Its effects are: clearing the liver and purging fire, dissipating swelling and nodules, and can treat breast abscess, breast nodulation, and breast distending pain. This herb is pungent to dissipate nodules and bitter to drain heat, and can treat goiter and scrofula, achieving the effects of clearing liver fire and dissipating phlegm nodules together.

[0024] Anemarrhena Rhizome: Bitter, sweet, cold. It acts on the lung, stomach and kidney meridians. Its functions are: clearing heat and purging fire, nourishing yin and moistening dryness. Entering the kidney meridian, it can nourish the kidney yin, purge the kidney fire, and reduce hectic fever. It is used to treat kidney yin deficiency, yin deficiency and excessive fire, hectic fever due to yin deficiency, spermatorrhea and night sweats. "Compendium of Materia Medica Preparation" records that Anemarrhena Rhizome moistens the kidney dryness and nourishes yin, entering the qi aspect of two meridians. Phellodendron Bark enters the blood aspect of two meridians, so the two herbs must be used in combination.

[0025] Rehmannia Root: Sweet, cold. It acts on the heart, liver and kidney meridians. Its functions are: clearing heat and cooling blood, nourishing yin and promoting the production of body fluid. Being sweet and cold, it enters the nutrient and blood aspects, being good at clearing heat and cooling blood. Nourishing yin and clearing heat, entering the kidney meridian, it can nourish the kidney yin and reduce deficiency fire, nourish the body fluid and drain latent heat. It is used to treat yin deficiency with internal heat and hectic fever due to yin deficiency.

[0026] Lophatherum Herb: Sweet, light, cold. It acts on the heart, stomach and small intestine meridians. Its functions are: clearing heat and purging fire, removing vexation and quenching thirst, promoting diuresis and relieving stranguria. Being cold in nature, it can clear the heart and reduce fire; being sweet and light, it can promote dampness and induce diuresis. It is used to treat sores and ulcers of the mouth and tongue caused by the upward flaring of heart fire, or short, red and painful urination due to the downward transfer of heart fire to the small intestine.

[0027] Scrophularia Root: Sweet, bitter, salty, slightly cold. It acts on the lung, stomach and kidney meridians. Its functions are: clearing heat and cooling blood, nourishing yin and reducing fire, detoxifying and dissipating nodules. Being sweet and cold in nature and moist in quality, it can clear heat and promote the production of body fluid, nourish yin and moisten dryness. "Compendium of Materia Medica Preparation" records: Its cold nature disperses fire, and its salty nature softens hardness, mainly treating scrofula and nodules.

[0028] Licorice Root: Sweet, flat. It acts on the heart, lung, spleen and stomach meridians. Its functions are: invigorating the spleen and replenishing qi, clearing heat and detoxifying, relieving spasm and pain, and coordinating the properties of various herbs.

[0029] Based on years of clinical experience in traditional Chinese medicine, the applicant of the present invention has conducted in-depth research on the disease of precocious puberty in children. It is believed that although the syndrome appears in the kidney, the disease actually originates from the liver, so the liver and kidney are treated together. The formula Longdan Xiegan Decoction in the "Prescriptions of the Bureau" can treat excessive fire and damp-heat in the liver and gallbladder meridians, flaccidity of the tendons, sweating in the genitals, swelling and pain of the genitals, leukorrhea with bloody urine, so Longdan is selected to purge the heat of the jueyin meridian. Li Dongyuan treated itching and foul odor in the anterior yin; Bupleurum Root soothes the heat of the shaoyang meridian, and Lophatherum Herb is used as an assistant to purge the dampness of the small intestine and bladder meridians. Alisma Orientalis in the original formula is replaced with Patrinia Scabiosaefolia and Smilax Glabra to drain the dampness of the kidney meridian. For the disease in the lower part, herbs are used to drain it, and Coix Seed and Achyranthes Bidentata Root are selected to drain damp-heat. Based on the syndrome differentiation theory of traditional Chinese medicine, starting from the whole, the combination of various herbs treats both the symptoms and the root causes, and has significant curative effects clinically. Detailed Implementation Modes

[0030] It should be noted that the following detailed descriptions are all illustrative and are intended to provide further explanations for the present application. Unless otherwise specified, all technical and scientific terms used herein have the same meaning as commonly understood by those of ordinary skill in the technical field to which the present application belongs.

[0031] To make the objectives, technical solutions and advantages of the embodiments of this application clearer, the following will clearly and completely describe the technical solutions in the embodiments of this application. Obviously, the described embodiments are only partial descriptions of the present invention, rather than all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without making creative efforts belong to the scope of protection of the present invention.

[0032] For those conditions not specified in the embodiments, they are carried out according to conventional conditions. For the reagents or instruments whose manufacturers are not specified, they are all conventional products that can be obtained through commercial purchase.

[0033] The embodiments of this application provide a traditional Chinese medicine composition for treating precocious puberty in children (syndrome of damp-heat pouring downward), which relates to the technical field of traditional Chinese medicine. It includes the following traditional Chinese medicines: bupleurum, patrinia scabiosaefolia, smilax glabra, coix seed, phellodendron amurense, achyranthes bidentata, gentiana scabra, tortoise shell, prunella vulgaris, anemarrhena asphodeloides, rehmannia glutinosa, lophatherum gracile, scrophularia ningpoensis and licorice root.

[0034] The basis of this invention lies in that: the inventor believes that although the syndrome is seen in the kidney, the disease actually originates from the liver, so the liver and kidney are treated together. The Bureau Prescription Gentiana Liver-Clearing Decoction can treat the excess fire and damp-heat in the liver and gallbladder meridians, flaccidity of the tendons, sweating of the genitals, swelling and pain of the genitals, leukorrhea with bloody urine, etc. Therefore, gentiana is selected to purge the heat of the jueyin meridian, and Li Dongyuan's treatment for itching and fetid odor in the anterior yin. Bupleurum soothes the heat of the shaoyang meridian, and lophatherum gracile purges the dampness of the small intestine and bladder as an assistant. The original rhizoma alismatis in the formula is replaced with patrinia scabiosaefolia and smilax glabra to purge the dampness of the kidney meridian. For the pathological changes in the lower part, coix seed and achyranthes bidentata are selected to purge damp-heat.

[0035] The clinical effect of this invention: This invention uses natural traditional Chinese medicine as raw materials, with definite curative effect and no toxic side effects. It can effectively treat precocious puberty in children of the damp-heat pouring downward type and promote children to enter a benign growth and development cycle. When using the medicine of this invention clinically, among the 110 patients included in the statistics, after taking the medicine for 3 - 5 courses of treatment, the symptoms can all be relieved or even disappear. In terms of clinical effect, after statistics, the cure rate is 89%, and the total effective rate reaches 98%.

[0036] Example 1:

[0037] Ratio: 10 g of bupleurum, 10 g of patrinia scabiosaefolia, 10 g of smilax glabra, 10 g of coix seed, 10 g of phellodendron amurense, 10 g of achyranthes bidentata, 10 g of gentiana scabra, 20 g of tortoise shell, 10 g of prunella vulgaris, 10 g of anemarrhena asphodeloides, 10 g of rehmannia glutinosa, 10 g of lophatherum gracile, 10 g of scrophularia ningpoensis, 5 g of licorice root.

[0038] Preparation and administration method: Decoct in water for oral administration, one dose every two days, divided into three times in the morning, middle and evening, and taken after meals.

[0039] Clinical case 1:

[0040] Patient: Zhang XX, female, 6 years and 3 months old

[0041] Initial diagnosis time: June 16, 2019.

[0042] Chief complaint: Abnormal vaginal discharge for more than half a year.

[0043] History of present illness: The patient developed right breast development half a year ago, with a breast nodule about 0.5×1.0 cm, hard in texture and significantly tender. There is no pubic hair, and white vaginal discharge can be seen. The patient is irritable, has a good appetite, has trouble falling asleep, has a bowel movement once a day, and normal urination.

[0044] The patient was included in the clinical case, and the patient was treated with the traditional Chinese medicine composition of the present invention. Prepared and taken according to the method described in "Example 1", 6 doses are one course of treatment, and a total of 2 courses of treatment were taken.

[0045] Follow-up and prognosis: Continuous follow-up until July 2022, no progressive breast development in both breasts, no vaginal discharge, and no menstruation.

[0046] Example 2:

[0047] Ratio: Bupleurum chinense 8g, Patrinia scabiosaefolia 8g, Smilax glabra 8g, Coix lacryma-jobi 8g, Phellodendron amurense 8g, Achyranthes bidentata 8g, Gentiana scabra 6g, Turtle shell 15g, Prunella vulgaris 8g, Anemarrhena asphodeloides 8g, Rehmannia glutinosa 8g, Lophatherum gracile 8g, Scrophularia ningpoensis 8g, Licorice 5g.

[0048] Preparation and administration method: Decoct in water for oral administration, one dose every two days, divided into three times in the morning, middle and evening, and taken after meals.

[0049] Clinical case 2:

[0050] Patient: Li Mou, female, 4 years and 11 months old

[0051] Initial diagnosis time: March 14, 2022.

[0052] Chief complaint: Definite precocious puberty in another hospital for 11 months.

[0053] History of present illness: The patient was diagnosed with "precocious puberty" in another hospital at the age of 4. When coming to our hospital for treatment, both breasts were developed, breast nodules were palpable, slightly tender to touch, vaginal discharge could be seen, with a large amount and yellow color, no pubic or axillary hair growth, poor appetite, restless sleep, dry stools, once a day, and normal urination.

[0054] The patient was included in the clinical case, and the patient was treated with the traditional Chinese medicine composition of the present invention. Prepared and taken according to the method described in "Example 2", 6 doses are one course of treatment, and a total of 2 courses of treatment were taken.

[0055] Follow-up and prognosis: Continuous follow-up until February 2023, no progressive breast development in both breasts, no vaginal discharge, and no menstruation.

[0056] Example 3:

[0057] Ratio: Bupleurum chinense 10g, Patrinia scabiosaefolia 10g, Smilax glabra 10g, Coix lacryma-jobi 10g, Phellodendron amurense 10g, Achyranthes bidentata 10g, Gentiana scabra 8g, Turtle shell 20g, Prunella vulgaris 10g, Anemarrhena asphodeloides 10g, Rehmannia glutinosa 10g, Lophatherum gracile 10g, Scrophularia ningpoensis 10g, Licorice 5g.

[0058] Preparation and administration method: Decoct in water for oral administration, one dose every two days, divided into three times in the morning, noon and evening, and take after meals.

[0059] Clinical case 3:

[0060] Child: Chen, female, 5 years old

[0061] Initial diagnosis time: February 5, 2023.

[0062] Chief complaint: Vaginal discharge was found for more than 1 month.

[0063] Current medical history: When the child visited the doctor, both breasts were developing, there was a small amount of light yellow vaginal discharge, the appetite was normal, the sleep was poor, it was a little difficult to fall asleep, easy to wake up, enuresis occurred 1-2 times, the urine was normal during the day, the stool was dry, once a day.

[0064] Included in the clinical case, the child was given the traditional Chinese medicine composition of the present invention for treatment. According to the preparation and administration method described in "Example 3", every 6 doses is a course of treatment, and a total of 2 courses of treatment were taken.

[0065] Follow-up and prognosis: When re-examined on March 12, 2023, both breasts shrank compared with before, there was no vaginal secretion, no pubic hair or armpit hair growth, and the weight decreased by 2.5 kg. The parents requested consolidation treatment.

[0066] Example 4:

[0067] Ratio: Bupleurum chinense 10g, Patrinia scabiosaefolia 10g, Smilax glabra 10g, Coix lacryma-jobi 15g, Phellodendron amurense 10g, Achyranthes bidentata 10g, Gentiana scabra 10g, Turtle shell 20g, Prunella vulgaris 10g, Anemarrhena asphodeloides 10g, Rehmannia glutinosa 10g, Lophatherum gracile 10g, Scrophularia ningpoensis 10g, Licorice 5g.

[0068] Preparation and administration method: Decoct in water for oral administration, one dose every two days, divided into three times in the morning, noon and evening, and take after meals.

[0069] Clinical case 4:

[0070] Child: Chen XX, female, 8 years and 9 months old

[0071] Initial diagnosis time: August 23, 2022.

[0072] Chief complaint: Menstruation for 1 month.

[0073] Present illness history: When the child came for treatment, one side of the breast was swollen, the right breast was harder, there was occasional breast burning and itching, a small amount of axillary hair and pubic hair could be seen, and yellowish-white vaginal discharge could be seen. Menarche occurred on August 18, 2022, lasting for 2 - 3 days, with dark red color, no blood clots, no abdominal pain, irregular menstruation, normal appetite, poor sleep, loose stools, once a day, normal urination, red tip of the tongue, and thin white coating.

[0074] The clinical case was included, and the child was treated with the traditional Chinese medicine composition of the present invention. According to the preparation method and administration method described in "Example 4", every 6 doses were taken as one course of treatment, and a total of 3 courses of treatment were taken.

[0075] Follow - up and prognosis: When the child came for a follow - up visit on October 18, 2023, both breasts had shrunk compared to before, there was no tenderness, there was no vaginal discharge, menstruation came regularly, and the height increased by 1.5 cm.

[0076] Finally, it should be noted that the above examples are only used to illustrate the technical solutions of the present invention, not to limit it; those of ordinary skill in the art should understand that they can still modify the technical solutions described in the foregoing examples, or perform equivalent replacements on some or all of the technical features; any equivalent replacement or change made according to the technical solutions of the present invention and its inventive concept should be covered within the protection scope of the present invention.

Claims

1. A traditional Chinese medicine composition for treating precocious puberty in children (syndrome of damp-heat pouring downward), characterized in that, It includes the following traditional Chinese medicines: Bupleurum chinense, Patrinia scabiosaefolia, Smilax glabra, Coix lacryma-jobi, Phellodendron amurense, Achyranthes bidentata, Gentiana scabra, Testudinis carapax, Prunella vulgaris, Anemarrhena asphodeloides, Rehmannia glutinosa, Lophatherum gracile, Scrophularia ningpoensis, Glycyrrhiza uralensis.

2. The traditional Chinese medicine composition for treating children's precocious puberty (syndrome of damp-heat pouring downward) according to claim 1, wherein, It includes the following traditional Chinese medicines by weight parts: Bupleurum chinense, Patrinia scabiosaefolia, Smilax glabra, Coix lacryma-jobi, Phellodendron amurense, Achyranthes bidentata, Gentiana scabra, Testudinis carapax, Prunella vulgaris, Anemarrhena asphodeloides, Rehmannia glutinosa, Lophatherum gracile, Scrophularia ningpoensis, Glycyrrhiza uralensis.

3. The traditional Chinese medicine composition for treating precocious puberty in children (syndrome of damp-heat pouring downward) according to claim 1, wherein, It includes the following traditional Chinese medicines by weight parts: 10 g of Bupleurum chinense, 10 g of Patrinia scabiosaefolia, 10 g of Smilax glabra, 10 g of Coix lacryma-jobi, 10 g of Phellodendron amurense, 10 g of Achyranthes bidentata, 10 g of Gentiana scabra, 20 g of Testudinis carapax, 10 g of Prunella vulgaris, 10 g of Anemarrhena asphodeloides, 10 g of Rehmannia glutinosa, 10 g of Lophatherum gracile, 10 g of Scrophularia ningpoensis, 5 g of Glycyrrhiza uralensis.

4. A traditional Chinese medicine composition for treating precocious puberty in children (syndrome of damp-heat pouring downward), as claimed in claim 1, wherein, It includes the following traditional Chinese medicines by weight parts: 8 g of Bupleurum chinense, 8 g of Patrinia scabiosaefolia, 8 g of Smilax glabra, 8 g of Coix lacryma-jobi, 8 g of Phellodendron amurense, 8 g of Achyranthes bidentata, 6 g of Gentiana scabra, 15 g of Testudinis carapax, 8 g of Prunella vulgaris, 8 g of Anemarrhena asphodeloides, 8 g of Rehmannia glutinosa, 8 g of Lophatherum gracile, 8 g of Scrophularia ningpoensis, 5 g of Glycyrrhiza uralensis.

5. A traditional Chinese medicine composition for treating precocious puberty in children (damp-heat pouring downward syndrome) according to claim 1, wherein, It includes the following traditional Chinese medicines by weight parts: 10 g of Bupleurum chinense, 10 g of Patrinia scabiosaefolia, 10 g of Smilax glabra, 10 g of Coix lacryma-jobi, 10 g of Phellodendron amurense, 10 g of Achyranthes bidentata, 8 g of Gentiana scabra, 20 g of Testudinis carapax, 10 g of Prunella vulgaris, 10 g of Anemarrhena asphodeloides, 10 g of Rehmannia glutinosa, 10 g of Lophatherum gracile, 10 g of Scrophularia ningpoensis, 5 g of Glycyrrhiza uralensis.

6. The traditional Chinese medicine composition for treating children's precocious puberty (syndrome of damp-heat pouring downward) according to claim 1, wherein, It includes the following traditional Chinese medicines by weight parts: 10 g of Bupleurum chinense, 10 g of Patrinia scabiosaefolia, 10 g of Smilax glabra, 15 g of Coix lacryma-jobi, 10 g of Phellodendron amurense, 10 g of Achyranthes bidentata, 10 g of Gentiana scabra, 20 g of Testudinis carapax, 10 g of Prunella vulgaris, 10 g of Anemarrhena asphodeloides, 10 g of Rehmannia glutinosa, 10 g of Lophatherum gracile, 10 g of Scrophularia ningpoensis, 5 g of Glycyrrhiza uralensis.

7. The traditional Chinese medicine composition for warming muscles and expelling cold-dampness between meridians according to any one of claims 1-2, characterized in that The dosage form of the traditional Chinese medicine composition is decoction or granule.