An adenogastritis modeling agent, its preparation method and application

The proventriculitis modeling agent, which is a complex of ZnO-OTA core and mesoporous silica shell, achieves efficient and stable construction of proventriculitis model, solving the problems of poor modeling effect and long cycle in existing methods, and realizing rapid and controllable construction of proventriculitis pathological model.

CN120392811BActive Publication Date: 2026-06-09WUHAN SUNHY BIOLOGICAL
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
WUHAN SUNHY BIOLOGICAL
Filing Date
2025-05-13
Publication Date
2026-06-09

AI Technical Summary

Technical Problem

Existing methods for prostategastroenteritis modeling have problems such as large differences between the modeling effect and the natural disease, success rate being affected by multiple factors, long cycle, and difficulty in controlling toxin dosage, making it difficult to meet the needs of high-throughput drug screening.

Method used

A ZnO-OTA core and mesoporous silica shell complex is used to bind ochratoxin A through electrostatic adsorption to form a pH-responsive nanocarrier, which enables the specific release of pathogenic factors in the proventriculus region, controls the OTA dose to be below the EU limit, and keeps the total ZnO content below the aquaculture standard.

Benefits of technology

A stable proventriculitis model with high pathological concordance rate can be established within 21 days, which is more than 30% shorter than traditional methods. It has low toxicity, controllable effect, and is suitable for the construction of pathological models of proventriculitis in broilers.

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Abstract

The present application relates to the technical field of experimental animal pathological model modeling, and more particularly to a glandular gastritis modeling agent, a preparation method and application thereof.The present application relates to a glandular gastritis modeling agent, which comprises a ZnO-OTA core and a mesoporous silica shell layer coated on the surface of the ZnO-OTA core; the ZnO-OTA core comprises amino zinc oxide nanoparticles and ochratoxin A.In the present application, the amino zinc oxide nanoparticles and ochratoxin A are combined through electrostatic adsorption, and then coated with mesoporous silica to form a core-shell structure; when applied to the construction of a broiler glandular gastritis pathological model, a stable and high-pathology-compliance glandular gastritis model can be established, the required time is short, the modeling effect is good, and a stable and high-pathology-compliance glandular gastritis model can be established within 21 days.
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