Arisaema erubescens with anti-inflammatory and nourishing functions and application thereof

Abstract

This invention belongs to the field of dietary therapy and health preservation, specifically disclosing a powder containing Artemisia annua, honeycomb, and osmanthus with both anti-inflammatory and nourishing functions, and its application. The raw materials include: dried Artemisia annua, honeycomb, beeswax, papain, monk fruit seeds, and freeze-dried osmanthus powder; the ratio of the dried Artemisia annua, honeycomb, beeswax, papain, monk fruit seeds, and freeze-dried osmanthus powder is 12:5:1:0.3:5:15. This invention utilizes the common anti-inflammatory properties of Artemisia annua, beeswax, and honeycomb, combined with the related functions of eggs, to rationally combine and utilize these ingredients to assist in the treatment of various inflammations in the human body, especially gastritis. The combined use of beeswax and honeycomb enhances their medicinal properties, improving efficacy. Simultaneously, the beneficial components contained in these materials can also enhance human immunity. The hunger-suppressing effect of beeswax and eggs is also beneficial for weight loss in obese individuals. Furthermore, the addition of monk fruit seeds to the raw materials of the powder gives it a slightly sweet taste, effectively improving its flavor and making it highly acceptable to the general population.

Description

Technical Field

[0001] This invention belongs to the field of dietary therapy and health preservation, specifically involving a powder containing Artemisia argyi and Osmanthus fragrans with both anti-inflammatory and nourishing functions, and its application. Background Technology

[0002] Chronic gastritis is a chronic inflammatory lesion of the gastric mucosa, a common and frequently occurring disease of the digestive system. Modern clinical treatment often employs bismuth-based quadruple therapy, supplemented with prokinetic drugs (such as mosapride), digestive aids (such as compound digestive enzymes), and acid-suppressing drugs (such as omeprazole). While these Western medical treatments are highly targeted, they have certain side effects and limitations in indications, and their effect on improving the patient's overall health is limited. Some traditional Chinese medicine preparations also have specific indications, but currently, there are no standardized products in dietary therapy that scientifically combine Artemisia annua, honeycomb products, and eggs to provide both anti-inflammatory and nourishing benefits for gastritis.

[0003] This invention, based on the principle of "medicine and food sharing the same origin," integrates traditional wisdom with modern research, and selects core ingredients such as Artemisia annua, beeswax, honeycomb, and eggs. It aims to provide a dietary therapy that can assist in the treatment of all types of gastritis from both broad-spectrum anti-inflammatory and immune-boosting perspectives, without toxic side effects. The technical background of each ingredient is as follows:

[0004] Artemisia annua (Artemisia): As a traditional Chinese medicine, its application has a long history, first recorded in "Fifty-Two Prescriptions". The Chinese Pharmacopoeia (2020 edition) records that it has the effects of clearing deficiency heat, relieving summer heat, eliminating bone steaming, reducing jaundice, and stopping malaria. Modern pharmacological research has confirmed that "Artemisia annua polysaccharide" contained in Artemisia annua has a good anti-inflammatory effect (Shuai Xuehong, Chen Jixuan, Shi Jun, et al. Preparation of Artemisia annua polysaccharide and study on its anti-inflammatory effect in vivo. Journal of Southwest University: Natural Science Edition, 2016, 38(9): 102-106). In folk medicine, the dietary application of Artemisia annua has a long history. For example, the "bitter grass (Artemisia annua) tea egg" used for postpartum recovery recorded in "Yongzheng Chongming County Annals" has the effects of promoting blood circulation, removing blood stasis, and reducing inflammation. In addition, it is also used for making sauces (patent number: CN201710823238.8) and brewing wine. Its food preparation techniques have become an intangible cultural heritage (No. 18 Hu Chongfu Fa

[2021] 18).

[0005] Eggs (formerly known as "Muxi") are neutral in nature and sweet in taste, entering the spleen, stomach, and lung meridians. They have nourishing and strengthening effects, as well as blood-nourishing and calming effects. Ancient medical classics such as "Fifty-Two Prescriptions," "Poultry and Egg Therapy," and "Medicinal Eggs Cure a Hundred Diseases" all record the widespread use of eggs in treating internal medicine, surgery, gynecology, pediatrics, and ENT diseases. Modern clinical observations and expert discussions further support their medicinal value. For example, Fang Lin, an expert in gastroenterology at Southern Medical University's Southern Hospital, points out that eggs are rich in high-quality protein and lecithin, which can supplement nutrition, promote metabolism, improve immunity, and help repair damaged gastric mucosa tissue. Xiao Yinglian, an expert in gastroenterology at the First Affiliated Hospital of Sun Yat-sen University, also points out that the lecithin in egg yolks can form a protective film on the surface of the gastric mucosa, reducing the stimulation of gastric acid and pepsin, and promoting the repair and regeneration of the gastric mucosa. This provides a scientific basis for the application of eggs in the adjunctive treatment of gastritis.

[0006] Beeswax and honeycomb: Beeswax is listed as a superior medicine in the *Shennong Bencao Jing* (Shennong's Classic of Materia Medica), which records that it "treats dysentery with pus and blood, nourishes the middle, benefits qi, prevents hunger, and promotes longevity." A study published in the top international food journal *Food Chemistry* (2018) states that "beeswax contains vitamin E and antioxidants, which may indirectly promote mucosal repair." Folk remedies, such as the one published in *Bee Magazine* (2017) which states that "2-3 grams of pure beeswax, chewed and swallowed three times a day, is mainly used to treat gastritis," provide further evidence.

[0007] Old honeycomb (referring to honeycomb older than 3 years and dark in color) has a complex composition, integrating various bioactive components such as beeswax, propolis, and bee pollen, thus possessing higher medicinal value. The journal *Chinese Beekeeping* (Issue 3, 1997) published an article titled "Old Honeycomb Has Special Effects in Treating Gastritis and Rhinitis," documenting a case where a patient was cured of long-term chronic gastritis after consuming "old honeycomb fried eggs." In folk medicine, chewing honeycomb is often used to treat gastritis, gastric ulcers, and other digestive system inflammations, with significant effects.

[0008] However, in existing technologies, there is no standardized powder product that combines the above-mentioned raw materials, especially with papain enzymatic hydrolysis to improve the extraction rate of Artemisia annua polysaccharides, and with Luo Han Guo seeds to improve the taste. Therefore, developing a Hao Chao Mu Xi powder that has clear therapeutic effects, good taste, and is easy to produce on a large scale and in a standardized manner has important practical significance and application value. Summary of the Invention

[0009] The purpose of this invention is to provide a powder containing Artemisia annua and Osmanthus fragrans with both anti-inflammatory and nourishing functions, and its application. By combining the anti-inflammatory properties of Artemisia annua, the antibacterial and anti-inflammatory properties of beeswax and honeycomb and their mucosal repair properties, and the nourishing and mucosal protection functions of eggs, a synergistic effect is achieved. This invention has sufficient traditional basis and modern scientific support to solve the problems mentioned in the background art.

[0010] To achieve the above objectives, the present invention provides the following technical solution:

[0011] A powder containing Artemisia annua, honeycomb, and osmanthus with both anti-inflammatory and nourishing properties, whose ingredients include: dried Artemisia annua, honeycomb, beeswax, papain, monk fruit seeds, and freeze-dried osmanthus powder;

[0012] The ratio of dried Artemisia annua, honeycomb, beeswax, papain, monk fruit seeds, and freeze-dried Osmanthus fragrans powder is 12:5:1:0.3:5:15.

[0013] Dried Artemisia annua contains active ingredients such as artemisinin, which are the core anti-inflammatory substances; by cutting, shredding, and drying with low moisture content, its effective components can be preserved to the maximum extent.

[0014] Beeswax (purified) or old honeycomb (over 3 years old) contains flavonoids, esters and other components, which have both nourishing and immune-boosting effects; the beeswax purification process (multiple melting and impurity removal) can improve the purity, and the long-term use of old honeycomb allows it to accumulate more active substances;

[0015] Osmanthus, or freeze-dried egg powder, provides high-quality protein and other nutrients, achieving a nourishing function. It also forms egg flowers at a specific temperature, making the nutrients easier to absorb.

[0016] Preferably, the preparation method of the Artemisia argyi powder includes:

[0017] S1. Artemisia annua, honeycomb, beeswax, and monk fruit seeds are extracted and decocted using the traditional Chinese medicine extract process to obtain the mother liquor.

[0018] S2. Cool the mother liquor (S1) to 50-60℃, add papain, and let stand for 3-4 hours;

[0019] S3. Concentrate the mother liquor (S2) containing papain under vacuum reduced pressure to a relative density of 1.10-1.25 at a temperature of 60°C.

[0020] S4. Add the concentrated mother liquor (S3) to the lyophilized osmanthus powder, stir well, let stand for 1 hour, freeze dry to obtain the initial product of osmanthus powder, grind through a 100-mesh sieve to obtain osmanthus powder.

[0021] Preferably, the decoction temperature in step S1, water extraction and decoction, is 80-100℃.

[0022] Preferably, the moisture content of the initial product of Artemisia annua is ≤5%.

[0023] The above-described application of Artemisia argyi powder, which has both anti-inflammatory and nourishing functions, in the preparation of food or health products for the adjunctive treatment of gastritis.

[0024] Based on the synergistic effect of the anti-inflammatory and nourishing properties of artemisia annua, beeswax, and eggs, this invention provides an artemisia annua powder with readily available materials and clear effects.

[0025] Compared with the prior art, the beneficial effects of the present invention are:

[0026] This invention utilizes the shared anti-inflammatory properties of Artemisia annua, beeswax, and honeycomb, combined with the relevant functions of eggs, to provide an adjunctive treatment for various inflammations in the human body, especially gastritis. The combined use of beeswax and honeycomb enhances their medicinal properties, improving efficacy and achieving full utilization of bee products. The materials are readily available, the effects are significant, and there are no toxic side effects. At the same time, the beneficial components contained in these materials can also enhance human immunity. The hunger-suppressing effects of beeswax and eggs can also help obese people lose weight. In addition, the addition of monk fruit seeds to the raw materials of Artemisia annua and honeycomb powder gives the product a slightly sweet taste, effectively improving its flavor and making it easily acceptable to both adults and children. The unique properties of monk fruit seeds also make it suitable for diabetics. Attached Figure Description

[0027] To more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings used in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort. Wherein:

[0028] Figure 1 This is a schematic diagram of the loose arrangement of *Osmanthus fragrans* according to the present invention;

[0029] Figure 2 This is a schematic diagram of the liquid state of the Artemisia argyi powder after brewing according to the present invention. Detailed Implementation

[0030] To make the above-mentioned objects, features and advantages of the present invention more apparent and understandable, the specific embodiments of the present invention will be described in detail below with reference to the accompanying drawings.

[0031] Many specific details are set forth in the following description in order to provide a full understanding of the invention. However, the invention may also be practiced in other ways different from those described herein, and those skilled in the art can make similar extensions without departing from the spirit of the invention. Therefore, the invention is not limited to the specific embodiments disclosed below.

[0032] Secondly, the term "one embodiment" or "embodiment" as used herein refers to a specific feature, structure, or characteristic that may be included in at least one implementation of the present invention. The phrase "in one embodiment" appearing in different places in this specification does not necessarily refer to the same embodiment, nor is it a single or selective embodiment that is mutually exclusive with other embodiments.

[0033] As attached Figure 1 As shown:

[0034] Example 1: This example provides a powder containing Artemisia annua and Osmanthus fragrans with both anti-inflammatory and nourishing functions. The raw materials include: dried Artemisia annua, honeycomb, beeswax, papain, monk fruit seeds, and freeze-dried Osmanthus fragrans powder.

[0035] The ratio of dried Artemisia annua, honeycomb, beeswax, papain, monk fruit seeds, and freeze-dried Osmanthus fragrans powder is 12:5:1:0.3:5:15.

[0036] Specifically, the preparation method of the Artemisia argyi powder includes:

[0037] S1. Artemisia annua, honeycomb, beeswax, and monk fruit seeds are extracted and decocted using the traditional Chinese medicine extract process to obtain the mother liquor.

[0038] S2. Cool the mother liquor (S1) to 50-60℃, add papain, and let stand for 3.5 hours;

[0039] S3. Concentrate the mother liquor (S2) containing papain under vacuum reduced pressure to a relative density of 1.10-1.25 at a temperature of 60°C.

[0040] S4. Add the concentrated mother liquor (S3) after depressurization to lyophilized osmanthus powder, stir well, let stand for 1 hour, freeze dry to obtain the initial product of osmanthus powder, grind through a 100-mesh sieve to obtain osmanthus powder.

[0041] Specifically, the decoction temperature in step S1, water extraction and decoction, is 90°C.

[0042] Specifically, the moisture content of the initial product of the Artemisia annua powder is 3%.

[0043] In summary, the combination of beeswax and honeycomb in this herbal powder aims to synergize their medicinal properties and enhance efficacy. This herbal powder uses readily available materials, has noticeable effects, no toxic side effects, and makes full use of bee products. It leverages the shared anti-inflammatory properties of Artemisia annua, beeswax, and honeycomb, along with the related functions of eggs, to provide adjunctive treatment for various inflammations, particularly gastritis. Furthermore, the beneficial components of these non-toxic materials can enhance the body's immunity, and the hunger-suppressing effects of beeswax and eggs can aid in weight loss for obese individuals. The addition of monk fruit seeds to the herbal powder gives it a slightly sweet taste, effectively improving its flavor and making it palatable for both adults and children. The unique properties of monk fruit seeds also make it suitable for diabetics.

[0044] Example 2: This example provides the application of the above-mentioned Artemisia argyi powder with both anti-inflammatory and tonic functions in the preparation of food or health products for the adjunctive treatment of gastritis.

[0045] From March 2024 to April 2025, 100 patients (volunteers) with chronic gastritis were selected as the observation objects, and were treated with the aid of Haochao Muxisǎn. At the same time, 40 patients with chronic gastritis were selected as the control group, and these patients were treated with Western medicine. The treatment effects of the two groups of patients were observed, and the TCM symptom scores, gastroscopy and pathological scores of the two groups of patients before and after treatment were compared. Results: The number of cases with clinical cure, marked effect and effective effect in the observation group was higher than that in the control group, and the total effective rate of treatment was significantly higher than that in the control group, with statistical significance (P<0.05); before treatment, there was no significant difference in the TCM symptom scores such as stomachache, acid regurgitation, stuffiness and fatigue between the two groups. After treatment, the above indicators of the two groups of patients decreased compared with before treatment, and the decrease in the observation group was more obvious (P<0.05); there was no significant difference in the gastroscopy score and pathological score between the two groups of patients before treatment. After treatment, the gastroscopy and pathological scores of the two groups of patients decreased, and the decrease in the observation group was more obvious (P<0.05).

[0046] Among the 100 patients, 55 had superficial gastritis and 45 had chronic atrophic gastritis, all of whom met the diagnostic criteria of "epigastric pain" or "block syndrome" in traditional Chinese medicine. Among them, there were 52 males and 48 females; the age ranged from 20 to 66 years old, 33 cases had a disease course of <5 years, 42 cases had a disease course of 5 - 10 years, and 25 cases had a disease course of more than 10 years. At the same time, 40 patients with chronic gastritis were selected as the control group, including 19 males and 21 females; the age ranged from 24 to 66 years old. There was no significant difference in the general data such as age, gender and disease course between the two groups of patients.

[0047] Methods: (1) Control group: Treated with conventional Western medicine, taking amoxicillin orally, 0.5 g each time, 3 times a day; taking omeprazole orally, 20 mg each time, 2 times a day. (2) Observation group: On the basis of the control group, Haochao Muxisǎn was additionally taken, and it was taken warm 1 hour after breakfast and dinner, 2 doses per day.

[0048] Clinical evaluation indicators: Observe the treatment effects of the two groups, and compare the TCM symptom scores, endoscopic and pathological scores of the two groups of patients before and after treatment. Curative effect evaluation criteria: Clinical cure: disappearance of clinical related symptoms and signs; Marked effect: basic disappearance of clinical main symptoms and signs, and the score decreased by more than 2 / 3; Effective: reduction of main symptoms and signs, and the score decreased by more than 1 / 3; Ineffective: failing to meet the above effective criteria or showing deterioration. The higher the TCM symptom score, endoscopic and pathological score, the more severe the symptoms or signs.

[0049] Statistics: All data were processed using SPSS 11.5 statistical software. Count data were expressed as cases or percentages, and measurement data were expressed as mean ± standard deviation. General data were processed using t-test or chi-square test according to the data type. The treatment effects of the patients were analyzed using chi-square test, and the TCM symptom scores, gastroscopy and pathological scores before and after treatment were statistically processed using t-test. P<0.05 was considered to indicate a statistically significant difference.

[0050] Clinical results:

[0051] 1. Comparison of clinical efficacy between the two groups: As shown in Table 1, the total effective rate of the observation group was significantly higher than that of the control group, which was statistically significant (P<0.05).

[0052] Table 1 Comparison of treatment effects between the two groups

[0053] Group n Clinical cure Effective efficient invalid Overall effectiveness (%) control group 40 11 11 10 8 80.0 Observation group 100 27 33 36 4 96.0

[0054] 2. Comparison of TCM symptom scores before and after treatment in the two groups: Before treatment, there was no significant difference in the TCM symptom scores of stomach pain, acid reflux, epigastric fullness, and fatigue between the two groups (P>0.05); after treatment, the above indicators in both groups decreased compared with before treatment, and the decrease was more significant in the observation group (P<0.05). See Table 2.

[0055] Table 2 Comparison of TCM symptom scores before and after treatment in the two groups

[0056] Before treatment After treatment

[0057] project control group Observation group control group Observation group stomachache 4.68±1.52 4.69±1.56 <![CDATA[1.89±1.02 * ]]> <![CDATA[1.02±0.58 *& ]]> acid reflux 4.27±1.47 4.28±1.52 <![CDATA[1.52±0.68 * ]]> <![CDATA[1.10±0.26 *& ]]> sullen 3.75±1.12 3.76±1.33 <![CDATA[2.13±1.01 * ]]> <![CDATA[1.05±0.87 *& ]]> fatigue 3.98±1.13 3.96±1.05 <![CDATA[2.08±1.02 * ]]> <![CDATA[0.97±0.22 *& ]]> Sigh 4.25±1.35 4.26±1.63 <![CDATA[2.85±1.12 * ]]> <![CDATA[1.65±0.86 *& ]]> Dry mouth and bitter taste 4.08±2.13 4.09±2.22 <![CDATA[2.07±0.63 * ]]> <![CDATA[1.54±0.48 *& ]]> Loose stools or constipation 4.15±2.05 4.16±1.89 <![CDATA[2.68±1.13 * ]]> <![CDATA[1.08±0.62 *& ]]>

[0058] 3. Comparison of gastroscopy and pathology scores before and after treatment in the two groups. Table 3 shows that there was no significant difference in gastroscopy and pathology scores before treatment in the two groups; after treatment, the gastroscopy and pathology scores of both groups decreased, and the decrease was more significant in the observation group (P<0.05).

[0059] Table 3 Comparison of gastroscopy and pathological scores before and after treatment in the two groups

[0060] project Group Before treatment After treatment t-value p-value Gastroscopy score control group 4.25±1.02 2.07±1.16 3.688 0.031 Observation group 4.23±1.13 1.52±0.98 4.952 0.026 Pathology score control group 3.78±1.13 2.32±1.05 3.156 0.037 Observation group 3.80±1.20 1.63±0.86 4.137 0.024

[0061] Conclusion: The combination of Haochao Muxi powder and commonly used Western medicines enhances the therapeutic effect on patients with chronic gastritis, significantly reducing clinical symptoms and lowering gastroscopy and pathological scores.

[0062] The present invention provides convenient consumption of Artemisia annua powder, which is conducive to standardized and large-scale production.

[0063] It should be understood that numerous specific implementation decisions can be made during the development of any practical implementation, such as in any engineering or design project. Such development efforts may be complex and time-consuming, but for those skilled in the art who benefit from this disclosure, the development effort will be a routine work of design, manufacturing, and production without requiring much experimentation.

[0064] It should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit it. Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention, and all such modifications or substitutions should be covered within the scope of the claims of the present invention.

Claims

1. A powder containing Artemisia argyi and Osmanthus fragrans with both anti-inflammatory and tonic properties, characterized in that... The ingredients include: dried Artemisia annua, honeycomb, beeswax, papain, monk fruit seeds, and freeze-dried Osmanthus fragrans powder; The ratio of dried Artemisia annua, honeycomb, beeswax, papain, monk fruit seeds, and freeze-dried Osmanthus fragrans powder is 12:5:1:0.3:5:

15.

2. The Artemisia annua and Osmanthus fragrans powder with both anti-inflammatory and tonic functions according to claim 1, characterized in that, The preparation method of the Artemisia argyi powder includes: S1. Artemisia annua, honeycomb, beeswax, and monk fruit seeds are extracted and decocted using the traditional Chinese medicine extract process to obtain the mother liquor. S2. Cool the mother liquor (S1) to 50-60℃, add papain, and let stand for 3-4 hours; S3. Concentrate the mother liquor (S2) containing papain under vacuum reduced pressure to a relative density of 1.10-1.25 at a temperature of 60°C. S4. Add the concentrated mother liquor (S3) to the lyophilized osmanthus powder, stir well, let stand for 1 hour, freeze dry to obtain the initial product of osmanthus powder, grind through a 100-mesh sieve to obtain osmanthus powder.

3. The Artemisia annua and Osmanthus fragrans powder with both anti-inflammatory and tonic functions according to claim 2, characterized in that, The decoction temperature in step S1, water extraction and decoction, is 80-100℃.

4. The Artemisia annua and Osmanthus fragrans powder with both anti-inflammatory and tonic functions according to claim 2, characterized in that, The moisture content of the initial product of the *Osmanthus fragrans* powder is ≤5%.

5. The application of the Artemisia argyi powder with both anti-inflammatory and tonic functions as described in any one of claims 1-4 in the preparation of food or health products for the adjunctive treatment of gastritis.

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