Multi-nuclear magnetic resonance scanning device, scanning imaging method thereof and readable storage medium

Abstract

The invention provides a multi-nuclear magnetic resonance scanning device, a scanning imaging method thereof and a readable storage medium, and belongs to the technical field of medical equipment. The multi-nuclide radio frequency emission unit is used for generating radio frequency signals of at least two different nuclides. The gradient magnetic field unit is used for providing a gradient magnetic field required by space coding. The multi-nuclide radio frequency receiving unit is used for receiving echo signals of different nuclides. The control unit is configured to adjust the sequence time sequence of the multi-nuclide radio frequency transmitting unit, the multi-nuclide radio frequency receiving unit and the gradient magnetic field unit, and parallel excitation and synchronous receiving of at least two different nuclides are achieved. Through the multi-nuclide radio frequency transmitting unit, the gradient magnetic field unit, the multi-nuclide radio frequency receiving unit and the control unit, parallel excitation of radio frequency signals of at least two different nuclides and synchronous receiving of echo signals of different nuclides are realized, the excitation frequency and the receiving time required by imaging are reduced, the imaging speed is improved, and the imaging efficiency is improved. The problem that a traditional device is low in imaging speed is solved.

Description

Technical Field

[0001] The present application belongs to the field of medical equipment technology, and in particular relates to a multi-nuclear magnetic resonance scanning device, a scanning imaging method thereof, and a readable storage medium. Background Art

[0002] Magnetic resonance imaging (NMR) is an analytical and detection technique developed based on the physical phenomena of the magnetism of atomic nuclei and their interaction with external magnetic fields. NMR offers advantages such as non-invasiveness, high safety, strong soft tissue resolution, and the ability to image in any plane and provide comprehensive observation. It is widely used in fields such as chemistry, biomedicine, and materials science.

[0003] However, conventional devices rely on time-division multiplexing or alternating acquisition at the receiving end, resulting in slow MRI speeds. Summary of the Invention

[0004] The purpose of this application is to provide a multi-nuclear magnetic resonance scanning device and its scanning imaging method, and a readable storage medium, aiming to solve the problem of slow imaging speed existing in traditional multi-nuclear magnetic resonance scanning devices.

[0005] The present application provides a multi-nuclear magnetic resonance scanning device, comprising:

[0006] a multi-nuclide radio frequency transmitting unit, configured to generate radio frequency signals of at least two different nuclides;

[0007] A gradient magnetic field unit, used for providing a gradient magnetic field required for spatial encoding;

[0008] a multi-nuclide radio frequency receiving unit, configured to receive echo signals of the different nuclides;

[0009] The control unit is configured to adjust the sequence timing of the multi-nuclide radio frequency transmitting unit, the multi-nuclide radio frequency receiving unit and the gradient magnetic field unit to achieve parallel excitation and synchronous reception of at least two different nuclides.

[0010] In one embodiment, the multi-nuclide radio frequency receiving unit includes a parallel processing unit for digitally processing the received echo signals.

[0011] In one embodiment, the parallel processing unit includes a plurality of independent processing cores, and each of the processing cores is responsible for performing the digital processing of the echo signal of one nuclear species.

[0012] In one embodiment, the parallel processing unit includes:

[0013] At least two separate radio frequency receiving channels, each of which receives an echo signal of a nuclear species and performs digital processing;

[0014] The radio frequency receiving channel at least includes a signal processing module, a filtering and frequency conversion processing module, and an acquisition control module.

[0015] In one embodiment, the filtering and frequency conversion processing module is connected to the received signal processing module, and is used to perform filtering and frequency conversion processing on the digital signal according to the filtering coefficient and frequency conversion parameter corresponding to each nuclide to obtain the signal to be imaged.

[0016] In one embodiment, the filtering and frequency conversion processing module includes:

[0017] An extraction module, configured to extract data from the frequency-converted signal to obtain the signal to be imaged;

[0018] a communication analysis module, configured to send the radio frequency coil identification to the digital filtering module and the down-conversion processing module to determine the filtering coefficient and the frequency conversion parameter corresponding to each nuclide;

[0019] The communication analysis module is connected to the extraction module and is used to obtain the signal to be imaged corresponding to each nuclide.

[0020] In one embodiment, the multi-nuclide radio frequency transmission unit includes:

[0021] At least two separate radio frequency transmission modules, each of which is connected to the control unit and the radio frequency coil module, and is used to transmit a radio frequency signal of a corresponding nuclide to the radio frequency coil module according to the sequence timing.

[0022] In one embodiment, each of the radio frequency transmission modules includes:

[0023] A radio frequency signal generating module, connected to the control unit, for generating a digital pulse signal for each nuclide according to the sequence timing and the radio frequency coil identifier;

[0024] The transmitting signal processing module is connected to the radio frequency signal generating module and is used to process the digital pulse signal to obtain the radio frequency signal corresponding to each nuclide.

[0025] In one embodiment, the acquisition control module is connected to the control unit and is used to obtain the sequence timing and the radio frequency coil identifier, and the acquisition control module controls the synchronous reception of the receiving signal processing module according to the sequence timing;

[0026] The control unit is connected to the radio frequency transmission module and is used to send the radio frequency coil identification to the radio frequency transmission module and control the parallel excitation of the radio frequency transmission module according to the sequence timing.

[0027] The present application provides a multi-nuclear magnetic resonance imaging method, comprising:

[0028] Based on the imaging parameters of the multi-nuclear magnetic resonance scan, controlling the multi-nuclide radio frequency transmitting unit to generate radio frequency signals of at least two different nuclides;

[0029] The gradient magnetic field unit provides the gradient magnetic field required for spatial encoding;

[0030] The multi-nuclide radio frequency receiving unit receives the echo signals of the different nuclides;

[0031] The control unit adjusts the sequence timing of the multi-nuclide radio frequency transmitting unit, the multi-nuclide radio frequency receiving unit and the gradient magnetic field unit;

[0032] The adjustment of the sequence timing realizes the parallel excitation of at least two different nuclides in the multi-nuclide radio frequency transmitting unit and the synchronous reception of at least two different nuclides by the multi-nuclide radio frequency receiving unit.

[0033] In one embodiment, the adjustment of the sequence timing includes adjusting the timing based on a preset transceiver mode; wherein the transceiver mode includes at least one or more of: an independent mode, a synchronous mode, a nuclear Overhauser effect mode, and a decoupling mode.

[0034] In one embodiment, the parallel excitation of at least two different nuclides in the multi-nuclide radio frequency emission unit includes:

[0035] A radio frequency signal that simultaneously excites at least two different nuclides; or

[0036] The radio frequency signal of at least two different nuclides is excited in a time-sharing manner.

[0037] In one embodiment, the multi-nuclide radio frequency receiving unit synchronously receives at least two different nuclides, including:

[0038] The echo signals of different nuclides enter the parallel processing unit at the same time and perform digital processing synchronously.

[0039] The present application provides a computer-readable storage medium, wherein the computer-readable storage medium stores a computer program. When the computer program is executed by a processor, the method described in the above embodiments is implemented.

[0040] An embodiment of the present application provides a computer program product. When the computer program product is run on a terminal device, the terminal device executes the multi-nuclear magnetic resonance scanning imaging method described in the above embodiment.

[0041] Compared with the prior art, the embodiments of the present invention have the following beneficial effects:

[0042] The multi-nuclide radio frequency transmitting unit can generate radio frequency signals of at least two different nuclides, which can be radio frequency signals of two different nuclides or radio frequency signals of three or more different nuclides. Each nuclide corresponds to a radio frequency signal. The sequence timing of the multi-nuclide radio frequency transmitting unit, the multi-nuclide radio frequency receiving unit and the gradient magnetic field unit can be adjusted by the control unit. The sequence timing includes the sequence information and timing control information required for magnetic resonance imaging. The sequence information can be understood as a series of combined sequences of radio frequency signals, gradient magnetic fields and signal reception and acquisition formed according to different clinical needs and imaging purposes, such as: spin echo sequence, gradient echo sequence or gradient echo sequence, etc., which can be adjusted according to actual needs. The timing control information can be understood as the time parameters and execution order of each sequence combination in the sequence information to ensure precise control of the radio frequency signal, gradient magnetic field and signal reception and acquisition in time.

[0043] The multi-nuclide RF transmitting unit transmits RF signals from at least two different nuclides at a time, and the gradient magnetic field unit provides the gradient magnetic field required for spatial encoding. This enables selective and parallel excitation of different layers or regions within the target area, generating excitation signals at multiple spatial locations. This reduces the number of excitations required for imaging and shortens scanning time. Consequently, the multi-nuclide RF receiving unit simultaneously receives echo signals from different nuclides at different spatial locations, achieving a single reception of at least two different nuclides, reducing the reception time required for imaging and avoiding the time-consuming traditional point-by-point acquisition.

[0044] Thus, through the multi-nuclide radio frequency transmitting unit, gradient magnetic field unit, multi-nuclide radio frequency receiving unit and control unit in the multi-nuclear magnetic resonance scanning device provided by the present application, parallel excitation of radio frequency signals of at least two different nuclides and synchronous reception of echo signals of different nuclides are achieved, reducing the number of excitations and receiving time required for imaging, improving the imaging speed, and solving the problem of slow imaging speed of traditional devices. BRIEF DESCRIPTION OF THE DRAWINGS

[0045] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the following briefly introduces the drawings required for use in the embodiments or exemplary technical descriptions. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without any creative work.

[0046] Figure 1 This is a schematic structural diagram of a multi-nuclear magnetic resonance scanning device in some embodiments provided in this application.

[0047] Figure 2 This is a schematic structural diagram of a multi-nuclide radio frequency receiving unit in some embodiments provided in this application.

[0048] Figure 3 This is a schematic structural diagram of a multi-nuclide radio frequency transmission unit in some embodiments provided in this application.

[0049] Figure 4 This is a schematic structural diagram of the imaging reconstruction module and the data storage module in some embodiments provided in this application.

[0050] Figure 5 This is a schematic diagram of the steps of the multi-nuclear magnetic resonance imaging method provided in this application. DETAILED DESCRIPTION

[0051] In order to make the technical problems, technical solutions and beneficial effects to be solved by this application more clearly understood, this application is further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain this application and are not intended to limit this application.

[0052] It should be noted that when an element is referred to as being “fixed on” or “disposed on” another element, it may be directly on the other element or indirectly on the other element. When an element is referred to as being “connected to” another element, it may be directly connected to the other element or indirectly connected to the other element.

[0053] It should be understood that the terms "length", "width", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", etc., indicating the orientation or position relationship, are based on the orientation or position relationship shown in the accompanying drawings, and are only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on this application.

[0054] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of the technical features being referred to. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of the features. Throughout the description of this application, "plurality" means two or more, unless otherwise specifically defined.

[0055] See Figure 1The present application provides a multi-nuclear magnetic resonance scanning device 100. The multi-nuclear magnetic resonance scanning device 100 includes a multi-nuclide radio frequency transmitting unit, a gradient magnetic field unit, a multi-nuclide radio frequency receiving unit, and a control unit 60. The multi-nuclide radio frequency transmitting unit is used to generate radio frequency signals of at least two different nuclides. The gradient magnetic field unit is used to provide the gradient magnetic field required for spatial encoding. The multi-nuclide radio frequency receiving unit is used to receive echo signals of different nuclides. The control unit 60 is configured to adjust the sequence timing of the multi-nuclide radio frequency transmitting unit, the multi-nuclide radio frequency receiving unit, and the gradient magnetic field unit to achieve parallel excitation and synchronous reception of at least two different nuclides.

[0056] In this embodiment, the multi-nuclide radio frequency transmitting unit can generate radio frequency signals of at least two different nuclides, which can be radio frequency signals of two different nuclides, or radio frequency signals of three or more different nuclides. Each nuclide corresponds to a radio frequency signal. The control unit 60 can adjust the sequence timing of the multi-nuclide radio frequency transmitting unit, the multi-nuclide radio frequency receiving unit, and the gradient magnetic field unit. The sequence timing includes the sequence information and timing control information required for magnetic resonance imaging. The sequence information can be understood as a series of combined sequences of radio frequency signals, gradient magnetic fields, and signal reception and acquisition formed according to different clinical needs and imaging purposes, such as: spin echo sequence, gradient echo sequence, or gradient echo sequence, which can be adjusted according to actual needs. The timing control information can be understood as the time parameters and execution order of each sequence combination in the sequence information to ensure precise control of the radio frequency signal, gradient magnetic field, and signal reception and acquisition in time.

[0057] The multi-nuclide RF transmitting unit transmits RF signals from at least two different nuclides at a time, and the gradient magnetic field unit provides the gradient magnetic field required for spatial encoding. This enables selective and parallel excitation of different layers or regions within the target area, generating excitation signals at multiple spatial locations. This reduces the number of excitations required for imaging and shortens scanning time. Consequently, the multi-nuclide RF receiving unit simultaneously receives echo signals from different nuclides at different spatial locations, achieving a single reception of at least two different nuclides, reducing the reception time required for imaging and avoiding the time-consuming traditional point-by-point acquisition.

[0058] Thus, through the multi-nuclide radio frequency transmitting unit, gradient magnetic field unit, multi-nuclide radio frequency receiving unit and control unit 60 in the multi-nuclear magnetic resonance scanning device 100 provided by the present application, parallel excitation of radio frequency signals of at least two different nuclides and synchronous reception of echo signals of different nuclides are achieved, thereby reducing the number of excitations and reception time required for imaging, improving the imaging speed, and solving the problem of slow imaging speed of traditional devices.

[0059] In one embodiment, the multi-nuclide radio frequency receiving unit includes a parallel processing unit for digitally processing the received echo signals.

[0060] In this embodiment, the parallel processing unit can simultaneously receive and process echo signals corresponding to multiple different nuclides, achieving digital processing of multiple data streams. Furthermore, the parallel processing unit can synchronously and parallelly receive echo signals from different nuclides and perform synchronous and parallel digital processing on the echo signals, thereby achieving fully digital data processing of the echo signals. Thus, by digitally processing the received echo signals, the accuracy and anti-interference capability of the echo signal processing process are improved, analog distortion is avoided, and the digital signal is more stable. This solves the problems of noise accumulation and signal distortion caused by the reception chain of traditional devices relying on analog circuits for signal processing.

[0061] In one embodiment, the parallel processing unit includes a plurality of independent processing cores, and each processing core is responsible for performing digital processing of the echo signal of a nuclear species.

[0062] In this embodiment, each processing core has its own logic resources, registers, and local memory, enabling independent digital processing of echo signals for a specific species. Simultaneously, multiple processing cores can each perform digital processing of their respective corresponding species' echo signals without waiting for each other. Multiple independent processing cores enable simultaneous and functionally independent digital processing of echo signals for multiple different species, providing greater flexibility and efficiency.

[0063] In one embodiment, the parallel processing unit may be a Field-Programmable Gate Array (FPGA), a Multi-core Application-Specific Integrated Circuit (ASIC), or a Multi-core Central Processing Unit (CPU). The multiple independent processing cores are computing units in the FPGA, multi-core ASIC, or multi-core CPU that can run in parallel and have independent functions.

[0064] In one embodiment, the parallel processing unit includes at least two separate RF receiving channels. Each RF receiving channel receives echo signals corresponding to a specific radionuclide and performs digital processing. Each RF receiving channel includes at least a received signal processing module 30, a filtering and frequency conversion processing module 40, and an acquisition control module 70.

[0065] In this embodiment, the received signal processing module 30 receives the echo signal, amplifies it, and performs analog-to-digital conversion processing to obtain a digital signal. The filtering and frequency conversion processing module 40 is connected to the received signal processing module 30 and performs filtering and frequency conversion processing on the digital signal based on the filter coefficients and frequency conversion parameters corresponding to each nuclear species to obtain the signal to be imaged. The acquisition control module 70 is connected to the filtering and frequency conversion processing module 40 to enable the transmission and exchange of various data between the two, as well as the control and analysis of related equipment and operations. Thus, the received signal processing module 30, the filtering and frequency conversion processing module 40, and the acquisition control module 70 form an RF receiving channel, which receives the echo signal of each nuclear species and performs digital processing.

[0066] In one embodiment, the received signal processing module 30 is used to receive an echo signal, and perform an amplification and analog-to-digital conversion process on the echo signal to obtain a digital signal.

[0067] In this embodiment, the echo signals received by each received signal processing module 30 are relatively weak. Amplifying the echo signals by the received signal processing module 30 can increase their signal strength and improve the signal-to-noise ratio to match the subsequent processing circuitry. The received signal processing module 30 also performs analog-to-digital conversion on the amplified echo signals, improving signal processing accuracy and stability. This facilitates subsequent processing by the filtering and frequency conversion processing module 40, facilitating data storage and transmission.

[0068] By means of at least two receiving signal processing modules 30, the echo signals of different nuclides can be received synchronously, and the echo signals can be amplified and subjected to analog-to-digital conversion to obtain digital signals, thereby realizing full digital data processing of the echo signals. This improves the anti-interference capability during the echo signal processing process, avoids analog distortion, and makes the digital signal more stable, thus solving the problems of noise accumulation and signal distortion caused by the receiving link of traditional devices relying on analog circuits for signal processing.

[0069] Furthermore, at least two receiving signal processing modules 30 directly receive echo signals of different nuclides, achieving direct front-end acquisition, allowing the echo signals to enter the receiving acquisition circuit directly. In other words, the analog echo signals are directly converted into digital signals using an ADC. Compared to indirect acquisition structures such as those used in traditional devices using orthogonal demodulators, the direct front-end acquisition structure provided by this application ensures high signal fidelity, strong real-time performance, simplicity, and efficiency of the echo signals. This is more conducive to improving the accuracy of echo signals of multiple different nuclides, thereby enhancing the accuracy of magnetic resonance imaging.

[0070] In one embodiment, the filtering and frequency conversion processing module 40 is connected to the received signal processing module 30 and is used to perform filtering and frequency conversion processing on the digital signal according to the filtering coefficient and frequency conversion parameter corresponding to each nuclide to obtain the signal to be imaged.

[0071] In this embodiment, a filtering and frequency conversion processing module 40 is connected to a received signal processing module 30. Each filtering and frequency conversion processing module 40 is configured to perform filtering and frequency conversion processing on the digital signal based on the filter coefficient and frequency conversion parameters corresponding to each nuclear species, thereby obtaining a signal to be imaged. Based on the filter coefficient corresponding to each nuclear species, the filtering and frequency conversion processing module 40 can determine the amplitude-frequency response and phase-frequency response, thereby ensuring smooth passage of digital signals within the frequency range corresponding to each nuclear species, while meeting the amplitude-frequency response requirements and minimizing phase distortion.

[0072] Based on the frequency conversion parameters corresponding to each nuclide, the filtering and frequency conversion processing module 40 can reduce the frequency of the digital signal from a high frequency range to a low frequency range, achieving down-conversion processing. This facilitates signal processing and analysis, enhances anti-interference capabilities, and facilitates signal transmission and storage. After the digital signal undergoes fully digital data processing by the filtering and frequency conversion processing module 40, it has the advantages of high precision and strong anti-interference, avoiding analog distortion, and obtaining more accurate imaging signals, thereby achieving more accurate reconstruction of magnetic resonance images.

[0073] Thus, through the receiving signal processing module 30 and the filtering and frequency conversion processing module 40 in the multi-nuclide RF receiving unit, full digital data processing of the echo signal is achieved, solving the problems of noise accumulation and signal distortion caused by the receiving link of the traditional device relying on analog circuits for signal processing.

[0074] In one embodiment, the multi-nuclear MRI scanning apparatus 100 further includes at least two RF coil modules 20. Each received signal processing module 30 is connected to each RF coil module 20. The received signal processing module 30, connected to the RF coil module 20, amplifies and performs analog-to-digital conversion on the echo signal, enabling front-end direct acquisition, allowing the echo signal to directly enter the receiving and acquisition circuit of the received signal processing module 30.

[0075] In one embodiment, each RF coil module 20 may include a pair of RF coils, namely, a RF transmitting coil and a RF receiving coil. Each RF coil module 20 may also include an integrated transceiver coil, using an RF switch to switch between transmit and receive functions. The RF coil module 20 may be adjusted and selected based on the actual application scenario. The RF coil module 20 may be configured as a volume transmit coil (VTC) or an LC coil, and the selection may be based on sequence information.

[0076] In one embodiment, multiple RF coil modules 20 are identical. Each coil interface provided on the bed supports data acquisition of up to 24 channels. Based on the sequence timing required for imaging and multiple RF coil identifiers, multiple radionuclides, multiple RF signals, and multiple RF coil modules 20 corresponding to different RF coil identifiers are configured. Furthermore, the multiple RF coil modules 20 can accommodate different radionuclides for transmission and reception based on the matching of RF coil identifiers and RF signals. All coil interfaces can support a variety of different radionuclides coils.

[0077] See Figure 2 In one embodiment, the received signal processing module 30 includes a broadband RF preamplifier module 310 and an analog-to-digital conversion module 320. The broadband RF preamplifier module 310 is configured to amplify the echo signal to obtain an amplified echo signal. The analog-to-digital conversion module 320 is connected to the broadband RF preamplifier module 310 and is configured to perform analog-to-digital conversion on the amplified echo signal to obtain a digital signal.

[0078] In this embodiment, the broadband RF preamplifier module 310 can be a high-sensitivity, low-noise broadband RF receiver. The broadband RF preamplifier module 310 amplifies the echo signal to achieve a wide frequency response range. This allows for stable amplification of signals with different resonance frequencies corresponding to different nuclides, thereby improving signal detection sensitivity and signal strength.

[0079] The analog-to-digital conversion module 320 is connected to the broadband RF preamplifier module 310 and is configured to perform analog-to-digital conversion on the amplified echo signal to obtain a digital signal, which is then sent to the digital filtering module 410. The analog-to-digital conversion module 320 converts the analog characteristics of the amplified echo signal output by the broadband RF preamplifier module 310 into digital characteristics to obtain a digital signal, thereby improving signal processing accuracy and facilitating signal storage and transmission. The analog-to-digital conversion module 320 may be an analog-to-digital converter.

[0080] At least two received signal processing modules 30 can respectively receive echo signals of at least two nuclides from at least two channels. Within the received signal processing modules 30, echo signals received by the broadband RF preamplifier module 310 are uniformly amplified and analog-to-digital converted, eliminating the need to process specific nuclides. Consequently, the broadband RF preamplifier module 310 and the analog-to-digital conversion module 320 improve the compatibility of the receiving end of the multi-nuclear MRI scanning device 100.

[0081] Furthermore, the broadband RF preamplifier module 310 directly receives the echo signal, achieving direct front-end acquisition, allowing the echo signal to directly enter the broadband RF preamplifier module 310 and the analog-to-digital conversion module 320. Compared to indirect acquisition structures such as those used by orthogonal demodulators in traditional devices, the direct front-end acquisition structure adopted by the multi-nuclear MRI scanning device 100 provided in this application can ensure high signal fidelity, strong real-time performance, simplicity and efficiency of the MRI signal, and is more conducive to improving the accuracy of the echo signals of multiple nuclides, thereby enhancing the accuracy of MRI imaging.

[0082] In one embodiment, a broadband RF preamplifier module 310 is connected to a RF coil module 20. Multiple receiving signal processing modules 30 are identical, and there is no need to match a fixed nuclide. Echo signals of different types of nuclides can be collected and processed at will. In the multi-nuclear magnetic resonance scanning device 100 provided in this application, the receiving signal processing module 30, the filtering and frequency conversion processing module 40, and the acquisition control module 70 form a RF receiving channel, and the RF transmitting module 10 forms a RF transmitting channel. The RF transmitting module 10, the RF coil module 20, the receiving signal processing module 30, and the filtering and frequency conversion processing module 40 form a RF channel to excite and receive the magnetic resonance signal of a nuclide. Multiple RF transmitting modules 10, multiple RF coil modules 20, multiple receiving signal processing modules 30, and multiple filtering and frequency conversion processing modules 40 can form multiple RF channels to excite and receive echo signals corresponding to multiple nuclides. Each RF channel is independent of each other, and the nuclides can be matched arbitrarily. It can achieve parallel excitation and synchronous reception of at least two different nuclides under the sequence timing requirements required for imaging, which is more flexible than traditional devices.

[0083] In one embodiment, the broadband RF preamplifier module 310 can be a unified broadband RF circuit capable of covering all target nuclide signal frequency bands. It does not need to be matched to a specific nuclide and can freely collect and process echo signals of different types of nuclides, thereby improving the compatibility of the receiving end of the multi-nuclear MRI scanning device 100. Furthermore, in the subsequently connected digital filter module 410 and down-conversion processing module 420, the filter coefficient and frequency conversion parameters corresponding to each nuclide are determined by the RF coil identifier, thereby enabling the distinction between different nuclides through software setting of the filter coefficient and frequency conversion parameters.

[0084] In one embodiment, the broadband RF preamplifier module 310 can also be a front-end dedicated RF circuit, which can be understood as a circuit customized and optimized for each nuclide, processing the characteristic signal frequency band of the corresponding nuclide, and realizing the use of different front-end dedicated RF circuits for different nuclides, with the advantages of high sensitivity and low power consumption.

[0085] In one embodiment, each filtering and frequency conversion processing module 40 includes a digital filtering module 410 and a down-conversion processing module 420. The digital filtering module 410 is connected to the received signal processing module 30 and is configured to filter the digital signal according to the filter coefficient to obtain a digital filtered signal. The down-conversion processing module 420 is connected to the digital filtering module 410 and is configured to down-convert the digital filtered signal according to the frequency conversion parameters to obtain a frequency-converted signal.

[0086] In this embodiment, the digital filter module 410 filters the digital signal according to the filter coefficient to obtain a digital filtered signal. The digital filter module 410 includes a plurality of filter coefficients. In one embodiment, the digital filter module 410 includes 1 H. 2 H. 3 He, 9 Li, 13 C. 17 O. 19 F. 23 Na, 31 P and 129 Multiple filter coefficients are available for over 10 nuclides, including Xe. The filter coefficients determine the filtering effect on the input digital signal. Different filter coefficients produce different filtering effects.

[0087] The digital filter module 410 selects the filter coefficient required for the corresponding nuclide. Furthermore, the digital filter module 410 filters the digital signal based on the filter coefficient. Each digital filter module 410 can implement different digital filtering functions depending on the filter coefficient, and can filter frequencies corresponding to different nuclides. Regardless of the nuclide, the digital filter module 410 can implement the digital filtering function. Therefore, the analog-to-digital conversion module 320, broadband RF preamplifier module 310, and RF coil module 20 connected to the digital filter module 410 do not need to be matched to a fixed nuclide and can be freely connected and selected for different types of nuclides without affecting the digital filter module 410's filtering function for the digital signal.

[0088] The down-conversion processing module 420 is connected to the digital filter module 410 and is used to perform frequency conversion processing on the digital signal according to the frequency conversion parameters to obtain a frequency conversion signal. The frequency conversion parameters can reflect the magnetic resonance frequency of the nuclide. The down-conversion processing module 420 includes multiple frequency conversion parameters. In one embodiment, the down-conversion processing module 420 includes 1 H. 2 H. 3 He, 9 Li, 13 C. 17 O. 19 F. 23 Na, 31 P and129 Multiple frequency conversion parameters are available for over ten nuclides, including Xe. The local oscillator frequency (LOF) is determined based on the nuclide's magnetic resonance frequency and the target downconversion frequency, thereby determining the frequency of the frequency-converted signal output by the downconversion processing module 420. The downconversion processing module 420 mixes the LFO frequency with the input digital signal to achieve frequency conversion and generate a frequency-converted signal.

[0089] Each down-conversion processing module 420 can implement different down-conversion functions based on different frequency conversion parameters, and can perform down-conversion processing on frequencies corresponding to different nuclides. Regardless of the nuclides, the down-conversion processing module 420 can implement the down-conversion processing function. Therefore, the digital filter module 410, analog-to-digital conversion module 320, broadband RF preamplifier module 310, and RF coil module 20 connected to the down-conversion processing module 420 do not need to be fixed to a specific nuclides and can be freely connected to different nuclides without affecting the down-conversion function of the down-conversion processing module 420.

[0090] In one embodiment, each filtering and frequency conversion processing module 40 further includes an extraction module 430 and a communication analysis module 440. The extraction module 430 is used to extract data from the frequency conversion signal to obtain a signal to be imaged.

[0091] The communication analysis module 440 is configured to transmit the RF coil identifier to the digital filtering module 410 and the down-conversion processing module 420. The digital filtering module 410 determines the filter coefficient corresponding to each nuclide based on the RF coil identifier. The down-conversion processing module 420 determines the frequency conversion parameters corresponding to each nuclide based on the RF coil identifier. The communication analysis module 440 is also connected to the extraction module 430 to obtain the imaging signal corresponding to each nuclide.

[0092] In this embodiment, the extraction module 430 is connected to the down-conversion processing module 420 to extract data from the frequency conversion signal to obtain the signal to be imaged. The extraction module 430 can select sample points from the frequency conversion signal to form a new discrete signal sequence with a reduced number of data points, which can further reduce the amount of data and processing complexity, reduce the data volume and storage requirements, and improve anti-interference capabilities. Thus, by processing the digital signal through the digital filtering module 410, the down-conversion processing module 420, and the extraction module 430, the compatibility of the multi-nuclear magnetic resonance scanning device 100 of the present application is increased, and signals corresponding to different types of nuclides can be arbitrarily excited and received, thereby improving the efficiency and accuracy of nuclear magnetic resonance imaging.

[0093] The communication analysis module 440 enables the transmission and exchange of various data between the filtering and frequency conversion processing module 40 and the acquisition control module 70, as well as the control and analysis of related devices and operations. The communication analysis module 440 can send the acquired imaging signal to the acquisition control module 70. The communication analysis module 440 can also transmit the RF coil identifier obtained from the acquisition control module 70 to the digital filtering module 410 and the down-conversion processing module 420, respectively.

[0094] Therefore, the digital filtering module 410 selects the filter coefficient corresponding to the nuclide associated with the RF coil identifier based on the RF coil identifier. Regardless of the nuclide associated with the RF coil identifier, the digital filtering module 410 selects the corresponding filter coefficient, thus implementing the digital filtering function. The down-conversion processing module 420 selects the frequency conversion parameters corresponding to the nuclide associated with the RF coil identifier based on the RF coil identifier. Regardless of the nuclide associated with the RF coil identifier, the down-conversion processing module 420 selects the corresponding frequency conversion parameters, thus implementing the down-conversion processing function.

[0095] In one embodiment, the control unit 60 is connected to an acquisition control module 70. The acquisition control module 70 is configured to obtain a sequence timing and a radio frequency coil identifier, control the synchronous reception of the received signal processing module 30 based on the sequence timing, and transmit the radio frequency coil identifier to the communication analysis module 440. Each acquisition control module 70 is also connected to the communication analysis module 440 to obtain the signal to be imaged.

[0096] In this embodiment, each acquisition control module 70 is connected to the control unit 60 and the communication analysis module 440 to obtain the RF coil identifier and send the RF coil identifier to the communication analysis module 440. Each acquisition control module 70 is connected to the communication analysis module 440 to acquire the to-be-imaged signal output by the communication analysis module 440 and send the to-be-imaged signal to the data storage module 80 for storage.

[0097] Each acquisition control module 70 is also connected to the broadband RF preamplifier module 310 in the receiving signal processing module 30, and is used to send an RF switch signal, a tuning signal, or a detuning signal to the broadband RF preamplifier module 310, control the working state of the broadband RF preamplifier module 310, and thus control the receiving time of the receiving signal processing module 30.

[0098] In one embodiment, the control unit 60 is further configured to adjust the sequence timing of the multi-nuclide RF transmitting unit, the multi-nuclide RF receiving unit, and the gradient magnetic field unit and the configuration of multiple different nuclides according to different imaging requirement information.

[0099] In this embodiment, the at least two broadband RF preamplifier modules 310 and the at least two analog-to-digital conversion modules 320 in the multi-nuclide RF receiving unit are not fixedly configured with a certain fixed nuclide, and the echo signals of different types of nuclides can be received, collected and processed at will. The at least two digital filter modules 410 and the at least two down-conversion processing modules 420 in the multi-nuclide RF receiving unit are not fixedly configured with a certain fixed nuclide, and the echo signals of different types of nuclides can be received, collected and processed at will. 1 H. 2 H. 3 He, 9 Li, 13 C. 17 O. 19 F. 23 Na, 31 P and 129 The filter coefficients and frequency conversion parameters corresponding to more than 10 types of nuclides such as Xe are selected to match the imaging requirement information to realize the digital filtering function and down-conversion processing function.

[0100] Thus, the control unit 60 adjusts the sequence timing of the multi-nuclide RF transmitting unit, the multi-nuclide RF receiving unit, and the gradient magnetic field unit and the configuration of multiple different nuclides according to different imaging requirement information, and sends the corresponding sequence timing and the configuration of multiple different nuclides to each unit. This enables the independence of each RF channel and the arbitrary matching of nuclides. It enables the parallel excitation and synchronous reception of at least two different nuclides under the sequence timing requirements required for imaging, which is more flexible and has a faster imaging speed than traditional devices.

[0101] In one embodiment, the control unit 60 is connected to the RF transmission module 10 and is configured to send the RF coil identification to the RF transmission module 10 and control the parallel excitation of the RF transmission module 10 according to the sequence timing.

[0102] In this embodiment, based on the sequence timing, multiple nuclide information required for imaging can be obtained. Combined with multiple RF coil identifiers, each RF coil module 20 is assigned a corresponding nuclide, resulting in each RF coil module 20 corresponding to both a nuclide and an RF coil identifier. The RF coil identifier can be understood as the identity of the RF coil, or the ID of the RF coil. Each RF coil identifier corresponds to a RF coil module 20 and can represent the identity of the RF coil module 20.

[0103] Each RF transmission module 10 generates an RF signal of a specific frequency and energy corresponding to each nuclide based on the matching relationship between each nuclide and the RF coil identifier in the sequence time series. Each nuclide corresponds to an RF signal of a specific frequency and energy. Consequently, a corresponding relationship is formed between each RF transmission module 10, each RF coil identifier, each nuclide, and each RF signal. Thus, the control unit 60 can control the parallel excitation of the RF transmission modules 10. At the receiving end, the control unit 60 can control the synchronous reception of the received signal processing module 30, and further enable the digital filtering module 410 and the down-conversion processing module 420 to select the filter coefficients and frequency conversion parameters corresponding to the corresponding nuclide based on the RF coil identifier.

[0104] In one embodiment, the multi-nuclide RF transmission unit includes at least two separate RF transmission modules 10. Each RF transmission module 10 is connected to the control unit 60 and the RF coil module 20, and is used to transmit the RF signal of the corresponding nuclide to the RF coil module 20 according to the sequence timing.

[0105] In this embodiment, multiple RF coil modules 20 are respectively connected to multiple RF transmitter modules 10 to form multiple excitation magnetic fields based on multiple RF signals to stimulate the tissue being tested. Each RF coil module 20 connected to each RF transmitter module 10 corresponds to one RF signal, one radionuclide, and one RF coil identifier. Different clinical requirements (also understood as imaging requirements) require different sequence timings, as well as different types and numbers of radionuclides. The radionuclides, RF signals, and RF coil identifiers are matched.

[0106] The multi-nuclear magnetic resonance scanning device 100 provided by the present application, the radio frequency transmission module 10, the radio frequency coil module 20, the receiving signal processing module 30 and the filter frequency conversion processing module 40 form a radio frequency channel to excite and receive the magnetic resonance signal of a nuclide. At least two separate radio frequency transmission modules 10, at least two separate radio frequency coil modules 20, at least two separate receiving signal processing modules 30, at least two separate filter frequency conversion processing modules 40 and at least two separate acquisition control modules 70 can form at least two separate radio frequency channels to excite and receive echo signals corresponding to at least two different nuclides. Furthermore, the multi-nuclear magnetic resonance scanning device 100 provided by the present application can provide richer echo signals of multiple nuclides, so that the accuracy of magnetic resonance imaging is high and the imaging speed is fast, the efficiency and precision of nuclear magnetic resonance imaging are improved, and the needs of multi-dimensional and multi-parameter analysis of complex samples can be met.

[0107] In one embodiment, multiple RF transmission modules 10, multiple RF coil modules 20, multiple received signal processing modules 30, and multiple filtering and frequency conversion processing modules 40 form multiple RF channels. Each RF channel is adapted to any one of different nuclides, such as hydrogen, helium, lithium, carbon, oxygen, fluorine, sodium, phosphorus, and xenon.

[0108] Based on the sequence timing required for imaging and multiple RF coil identifiers, multiple RF transmission modules 10 establish a bridge connecting multiple RF signals, multiple nuclides, multiple RF coil modules 20, and multiple filtering and frequency conversion processing modules 40. Different RF coil identifiers can randomly correspond to different nuclides, thereby matching different RF signals with RF coil modules 20 to achieve parallel excitation and synchronous reception of signals. Furthermore, in the filtering and frequency conversion processing module 40, filter coefficients and frequency conversion parameters corresponding to different nuclides are set based on different RF coil identifiers. The digital signals received by the RF coil modules 20 and processed by the received signal processing module 30 are filtered and frequency converted to obtain the imaging signal to reconstruct the magnetic resonance image.

[0109] Thus, through the multi-nuclear magnetic resonance scanning device 100 provided by the present application, multiple RF transmission modules 10, multiple RF coil modules 20, multiple receiving signal processing modules 30, and multiple filtering and frequency conversion processing modules 40 do not need to be fixedly corresponding to a certain nuclide, and different nuclides can be matched according to the actual application scenario requirements.

[0110] In one embodiment, the present application provides a multi-nuclear magnetic resonance scanning device 100 that can be configured 1 H. 2 H. 3 He, 9 Li, 13 C. 17 O. 19 F. 23 Na, 31 P and 129 More than 10 nuclides including Xe.

[0111] In one embodiment, one RF transmission module 10, one RF coil module 20, one receiving signal processing module 30, and one filtering and frequency conversion processing module 40 form a RF channel, which can be used to excite and receive signals of H nuclides. Four RF transmission modules 10, four RF coil modules 20, four receiving signal processing modules 30, and four filtering and frequency conversion processing modules 40 form four separate RF channels, respectively realizing four X nuclides (for example: 3 He, 9 Li, 13 C. 17 O.19 F. 23 Na, 31 P and 129 Any 4 of Xe) can perform parallel excitation and synchronous reception of signals.

[0112] In one embodiment, multiple radio frequency channels perform independent, simultaneous, time-sharing, decoupled, or Nuclear Overhauser Effect (NOE) acquisition of multiple nuclides. Thus, the multi-nuclear magnetic resonance scanning apparatus 100 provided herein provides greater flexibility in acquiring and detecting multiple nuclides.

[0113] See Figure 3 In one embodiment, each RF transmission module 10 includes a RF signal generating module 110. The RF signal generating module 110 is connected to the control unit 60 and is configured to generate a digital pulse signal for each nuclide according to the sequence timing and the RF coil identifier.

[0114] In this embodiment, each RF signal generating module 110 is connected to the control unit 60 and is used to generate a digital pulse signal corresponding to each nuclide according to the sequence timing and the RF coil identification. The RF signal generating module 110 includes an RF transmitter that can generate a plurality of different types of nuclides (for example: 1 H. 2 H. 3 He, 9 Li, 13 C. 17 O. 19 F. 23 Na, 31 P and 129 Furthermore, by using at least two RF signal generation modules 110, digital pulse signals corresponding to different types of nuclides can be generated at will, without having to match a fixed nuclide, thereby enabling the configuration of multiple different nuclides according to imaging requirements.

[0115] In one embodiment, the multiple RF signal generating modules 110 may use independent transmission power supplies.

[0116] In one embodiment, each RF transmission module 10 further includes a transmission signal processing module 120. The transmission signal processing module 120 is connected to the RF signal generation module 110 and is configured to perform digital-to-analog conversion, filtering, and amplification on the digital pulse signal to obtain a RF signal corresponding to each nuclide.

[0117] In this embodiment, a transmit signal processing module 120 is connected to a RF signal generating module 110. Each transmit signal processing module 120 is configured to perform digital-to-analog conversion, filtering, and amplification on the digital pulse signal to obtain a corresponding RF signal for each nuclide. Each transmit signal processing module 120 performs digital-to-analog conversion, filtering, and amplification on the digital pulse signal to obtain a corresponding RF signal for each nuclide, which is then transmitted to the corresponding RF coil module 20.

[0118] Furthermore, through the at least two RF signal generating modules 110 and the at least two transmitting signal processing modules 120 in the RF transmitting module 10, it is possible to generate digital pulse signals corresponding to different types of nuclides at will without having to match a certain fixed nuclide, and perform digital-to-analog conversion, filtering and amplification on the digital pulse signals to form RF signals corresponding to at least two nuclides, which can match 1 H. 2 H. 3 He, 9 Li, 13 C. 17 O. 19 F. 23 Na, 31 P and 129 At least two of any of more than 10 nuclides such as Xe. Thus, the RF transmitting module 10 can realize the parallel transmission of RF signals of at least two different nuclides to match the synchronous reception of the RF receiving unit.

[0119] In one embodiment, each transmit signal processing module 120 includes a digital-to-analog conversion module 121, an analog filtering module 122, and an RF power amplification module 123. The digital-to-analog conversion module 121 is connected to the RF signal generation module 110 and is configured to perform digital-to-analog conversion on the digital pulse signal to obtain an analog pulse signal. The analog filtering module 122 is connected to the digital-to-analog conversion module 121 and is configured to filter the analog pulse signal to obtain an analog filtered signal. The RF power amplification module 123 is connected to the analog filtering module 122 and is configured to amplify the analog filtered signal to obtain the RF signal of each nuclide.

[0120] In this embodiment, the digital pulse signal generated by the RF signal generating module 110 is converted into an analog signal by the DAC module 121, thereby generating an analog pulse signal, which is conducive to exciting the RF coil module 20 to generate an excitation magnetic field to stimulate the nuclear magnetic resonance signal of the corresponding nuclide in the measured tissue.

[0121] The RF signal generation module 110 is connected to the analog filter module 122, whose operating state is controlled by an RF switch signal. The analog filter module 122 filters the analog pulse signal, achieving frequency selection and signal purification for different types of nuclides, while suppressing harmonics and spurious signals to ensure the spectral purity of the RF signal.

[0122] The analog filtered signal is amplified by the RF power amplifier module 123 so that the RF signal can drive the RF coil module 20, thereby generating a strong RF magnetic field around the tissue being measured to stimulate the generation of magnetic resonance signals, which is beneficial to improving imaging quality and efficiency.

[0123] In one embodiment, the RF power amplification module 123 may be a RF power amplifier, the digital-to-analog conversion module 121 may be a digital-to-analog converter, and the analog filtering module 122 may be a filter.

[0124] See Figure 4 In one embodiment, the gradient magnetic field unit includes a gradient module 90 connected to the control unit 60 and the gradient coil assembly within the main magnet. This module controls the gradient coil assembly to generate gradient magnetic fields in the X, Y, and Z directions, corresponding to slice selection gradients, phase encoding gradients, and frequency encoding gradients, respectively, to achieve spatial encoding. Furthermore, the gradient module 90 enables the selection of specific imaging slices (e.g., transverse, coronal, and sagittal planes) in three dimensions.

[0125] During the spatial encoding phase, the gradient magnetic field unit simultaneously applies the same gradient to all different nuclides, enabling gradient magnetic field-assisted positioning. The gradient magnetic field applied by the gradient magnetic field unit has a fixed effect on the frequencies of different nuclides, making gradient field-based spatial encoding universal. This eliminates the need for a dedicated encoding scheme for each nuclide, simplifying system design and signal processing.

[0126] In one embodiment, the Z-axis gradient field is generated by controlling the gradient coil assembly so that the frequencies of all different nuclear species vary linearly in space, for example, the frequency variation slopes of 1H and 31P are consistent.

[0127] In one embodiment, the gradient module 90 includes components such as a gradient amplifier, a gradient controller, a cooling system, a gradient power supply, and a feedback circuit.

[0128] In one embodiment, the multi-nuclear MRI scanning apparatus 100 further includes an imaging reconstruction module 50. The imaging reconstruction module 50 is configured to obtain multiple RF coil identifiers when the multiple RF coil modules 20 are respectively connected to the multiple RF transmitting modules 10 and the multiple received signal processing modules 30. The imaging reconstruction module 50 is also configured to obtain imaging requirement information.

[0129] The control unit 60 is connected to the imaging reconstruction module 50 and is used to obtain multiple RF coil identifiers and imaging requirement information, generate a sequence timing according to the imaging requirement information, and send the sequence timing and multiple RF coil identifiers to each RF transmission module 10.

[0130] When multiple RF coil modules 20 are respectively connected to multiple RF transmitting modules 10 and multiple received signal processing modules 30, multiple RF coil identifiers corresponding to the multiple RF coil modules 20 are sent to the imaging reconstruction module 50. Each time multi-nuclear MRI imaging is performed using the multi-nuclear MRI scanning device 100, a correspondence is established between each RF coil module 20, each RF transmitting module 10, each RF coil identifier, each nuclear species, and each RF signal, based on imaging requirements.

[0131] The imaging reconstruction module 50 transmits multiple RF coil identifiers to the control unit 60, and then transmits them to the multiple RF transmission modules 10 and the multiple acquisition control modules 70 via the control unit 60. The imaging reconstruction module 50 is connected to the multiple acquisition control modules 70 via the data storage module 80 to acquire multiple signals to be imaged. The imaging reconstruction module 50 reconstructs the multiple signals to be imaged using an imaging reconstruction algorithm to obtain magnetic resonance images. In one embodiment, the imaging reconstruction module 50 can be a device such as a computer.

[0132] In one embodiment, the data storage module 80 can store the multiple signals to be imaged output by the multiple acquisition control modules 70 and send the multiple signals to be imaged to the imaging reconstruction module 50 for imaging.

[0133] In one embodiment, the broadband RF preamplifier module 310, the analog-to-digital conversion module 320, the digital filtering module 410, the down-conversion processing module 420, the extraction module 430, the communication analysis module 440 and the acquisition control module 70 can be integrated into a parallel processing unit, or they can be implemented separately as independent modules to implement the functions of the above-mentioned embodiments.

[0134] See Figure 5 The present application provides a multi-nuclear magnetic resonance imaging method, comprising:

[0135] Step S10, based on the imaging parameters of the multi-nuclear magnetic resonance scan, controlling the multi-nuclide radio frequency transmitting unit to generate radio frequency signals of at least two different nuclides;

[0136] Step S20: The gradient magnetic field unit provides the gradient magnetic field required for spatial encoding;

[0137] Step S30, the multi-nuclide radio frequency receiving unit receives echo signals of different nuclides;

[0138] In step S40, the control unit 60 adjusts the sequence timing of the multi-nuclide RF transmitting unit, the multi-nuclide RF receiving unit, and the gradient magnetic field unit; wherein the adjustment of the sequence timing enables parallel excitation of at least two different nuclides in the multi-nuclide RF transmitting unit and synchronous reception of at least two different nuclides by the multi-nuclide RF receiving unit.

[0139] In this embodiment, the relevant descriptions of step S10, step S20, step S30 and step S40 may refer to the relevant descriptions in the above embodiments.

[0140] In one embodiment, adjusting the sequence timing includes adjusting the timing based on a preset transceiver mode, wherein the transceiver mode includes at least one or more of: an independent mode, a synchronous mode, a NOE mode, and a decoupling mode.

[0141] In this embodiment, in independent mode, independent transmission and reception time windows are assigned to different nuclides. Furthermore, based on the preset independent mode adjustment timing, each radio frequency transmission module 10 in the multi-nuclide radio frequency transmission unit is controlled to transmit radio frequency signals within the independent transmission time windows corresponding to the corresponding different nuclides. Based on the preset independent mode adjustment timing, each receiving signal processing module 30 in the multi-nuclide radio frequency receiving unit is controlled to receive echo signals within the independent receiving time windows corresponding to the corresponding different nuclides, so as to achieve the extraction of effective echo signals within each receiving time window. By adjusting the timing in independent mode, mutual interference between different nuclides with similar frequency bands can be avoided, thereby improving the accuracy of the multi-nuclear magnetic resonance scanning imaging method and facilitating improved imaging quality and efficiency.

[0142] In synchronous mode, different nuclides are assigned the same transmission and reception time windows. Furthermore, based on the preset synchronous mode timing adjustment, each RF transmission module 10 in the multi-nuclide RF transmission unit is controlled to transmit RF signals corresponding to all nuclides simultaneously within the same transmission time window. Based on the preset synchronous mode timing adjustment, each received signal processing module 30 in the multi-nuclide RF receiving unit is controlled to receive all echo signals simultaneously within the same reception time window. This synchronous mode timing adjustment captures transient coupling effects, facilitating the acquisition of more comprehensive imaging signals.

[0143] In the Nuclear Overhauser Effect (NOE) mode, the NOE effect is used to obtain molecular structural information, increasing the nuclear magnetic resonance signal through spatial proximity. Based on the preset NOE mode timing adjustment, the RF transmission module 10 in the multi-nuclide RF transmission unit is controlled to first transmit the RF signal of the transfer nuclide, and then transmit the RF signal of the target nuclide after a predetermined delay. Adjusting the timing in the NOE mode can enhance the echo signal of low-sensitivity nuclides, which is beneficial for improving imaging quality.

[0144] In decoupling mode, interfering RF pulses are applied to eliminate or weaken coupling effects between nuclear spins (such as J coupling and dipole coupling). Based on the preset decoupling mode, the timing is adjusted to control the RF transmission module 10 in the multi-nuclide RF transmission unit to continuously transmit decoupling RF pulses of the interfering nuclide, thereby controlling the various receiving signal processing modules 30 in the multi-nuclide RF receiving unit to receive the echo signal of the target nuclide under the interference of the decoupling RF pulses. Adjusting the timing in decoupling mode can eliminate or weaken spectral line splitting caused by J coupling and other factors, which is beneficial for improving imaging quality.

[0145] When one or more of the preset independent mode, synchronous mode, NOE mode, and decoupling mode are used to adjust the timing, the control unit 60 can adjust the sequence timing of the multi-nuclide radio frequency transmitting unit, the gradient magnetic field unit, and the multi-nuclide radio frequency receiving unit. Furthermore, when the control unit 60 adjusts the sequence timing of the multi-nuclide radio frequency transmitting unit, the multi-nuclide radio frequency receiving unit, and the gradient magnetic field unit, the architecture of the receiving signal processing module 30, the filtering and frequency conversion processing module 40, and the acquisition control module 70 at the receiving end does not change with the sequence timing under different acquisition modes. Through the hardware fixed support of the multi-nuclear magnetic resonance scanning device 100 provided by the present application, multi-nuclear magnetic resonance scanning imaging under different acquisition modes can be achieved.

[0146] In one embodiment, in step S40, the parallel excitation of at least two different nuclides in the multi-nuclide radio frequency emission unit includes:

[0147] Step S410, simultaneously exciting radio frequency signals of at least two different nuclides; or,

[0148] The radio frequency signal of at least two different nuclides is excited in a time-sharing manner.

[0149] In this embodiment, stimulating radio frequency signals of at least two different nuclides within the same emission time window can save scanning time, significantly improve detection efficiency and time utilization, and enhance the time synchronization and physiological relevance of the signals.

[0150] Sequentially exciting the radio frequency signals of at least two different nuclides within different emission time windows can avoid radio frequency interference between nuclides, improve signal purity, reduce the risk of energy deposition, and enhance safety.

[0151] In one embodiment, in step S40, the multi-nuclide radio frequency receiving unit synchronously receives at least two different nuclides, including:

[0152] In step S420 , the echo signals of different nuclides enter the parallel processing unit at the same time and are digitally processed synchronously.

[0153] In this embodiment, the echo signals of all different nuclides enter the parallel processing unit at the same time to realize the digital processing of multiple data streams. The echo signals of different nuclides are received by the broadband RF preamplifier receiver in the parallel processing unit and uniformly sampled by the analog-to-digital converter (ADC). Due to the difference in Larmor frequency of different nuclides (for example, 1H=64MHz, 31P=25MHz), the corresponding signals can be naturally separated in the frequency domain. Furthermore, the digital filtering function and the down-conversion processing function in the parallel processing unit respectively select the filter coefficients and frequency conversion parameters corresponding to the nuclides in real time for filtering and frequency conversion processing, separate the echo signals in real time, realize frequency division multiplexing, and isolate the target frequency band signal.

[0154] The present application provides a medical device, including the multi-nuclear magnetic resonance scanning device 100 according to any of the above embodiments. The medical device can be a magnetic resonance imager, a magnetic resonance angiography device, a magnetic resonance spectroscopy imaging device, a functional magnetic resonance imaging device, a magnetic resonance guided radiotherapy device, or a magnetic resonance interventional device.

[0155] An embodiment of the present application further provides a computer-readable storage medium, wherein the computer-readable storage medium stores a computer program, and when the computer program is executed by a processor, the steps in the above-mentioned various method embodiments can be implemented.

[0156] An embodiment of the present application provides a computer program product. When the computer program product is run on a mobile terminal, the mobile terminal can implement the steps in the above-mentioned various method embodiments when executing the computer program product.

[0157] Those skilled in the art can clearly understand that, for the convenience and simplicity of description, only the division of the above-mentioned functional units and modules is used as an example for illustration. In actual applications, the above-mentioned functions can be distributed and completed by different functional units and modules as needed, that is, the internal structure of the device can be divided into different functional units or modules to complete all or part of the functions described above. The functional units and modules in the embodiment can be integrated into one processing unit, or each unit can exist physically alone, or two or more units can be integrated into one unit. The above-mentioned integrated unit can be implemented in the form of hardware or in the form of software functional units. In addition, the specific names of the functional units and modules are only for the convenience of distinguishing each other and are not used to limit the scope of protection of this application.

[0158] In the above embodiments, the description of each embodiment has its own focus. For parts that are not described or recorded in detail in a certain embodiment, reference can be made to the relevant description of other embodiments.

[0159] Those skilled in the art will appreciate that the units and algorithm steps of each example described in conjunction with the embodiments disclosed herein can be implemented in electronic hardware, or a combination of computer software and electronic hardware. Whether these functions are performed in hardware or software depends on the specific application and design constraints of the technical solution. Professional and technical personnel can use different methods to implement the described functions for each specific application, but such implementation should not be considered beyond the scope of this application.

[0160] The division of modules or units described above is merely a logical functional division. In actual implementation, other divisions may be employed. For example, multiple units or components may be combined or integrated into another system, or some features may be omitted or not implemented. Furthermore, any coupling or direct coupling or communication connection shown or discussed between components may be an indirect coupling or communication connection via an interface, device, or unit, and may be electrical, mechanical, or other.

[0161] The units described as separate components may or may not be physically separate, and the components shown as units may or may not be physical units, that is, they may be located in one place or distributed across multiple network units. Some or all of these units may be selected to achieve the purpose of this embodiment according to actual needs.

[0162] In addition, the functional units in the various embodiments of the present application may be integrated into a single processing unit, or each unit may exist physically separately, or two or more units may be integrated into a single unit. The aforementioned integrated units may be implemented in the form of hardware or software functional units.

[0163] If the integrated module / unit is implemented in the form of a software functional unit and sold or used as an independent product, it can be stored in a computer-readable storage medium. The computer program includes computer program code, which can be in source code form, object code form, executable file or some intermediate form. The computer-readable medium may include: any entity or device that can carry the computer program code, recording medium, USB flash drive, mobile hard disk, magnetic disk, optical disk, computer memory, read-only memory (ROM), random access memory (RAM), electric carrier signal, telecommunication signal and software distribution medium, etc. It should be noted that the content contained in the computer-readable medium can be appropriately increased or decreased according to the requirements of legislation and patent practice in the jurisdiction. For example, in some jurisdictions, according to legislation and patent practice, computer-readable media do not include electric carrier signals and telecommunication signals.

[0164] The above-described embodiments are only used to illustrate the technical solutions of the present application, rather than to limit them. Although the present application has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or make equivalent replacements for some of the technical features therein. These modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the various embodiments of the present application, and should all be included in the scope of protection of the present application.

Claims

1. A multi-nuclear magnetic resonance scanning device, characterized in that: include: a multi-nuclide radio frequency transmitting unit, configured to generate radio frequency signals of at least two different nuclides; A gradient magnetic field unit, used for providing a gradient magnetic field required for spatial encoding; a multi-nuclide radio frequency receiving unit, configured to receive echo signals of the different nuclides; The control unit (60) is configured to adjust the sequence timing of the multi-nuclide radio frequency transmitting unit, the multi-nuclide radio frequency receiving unit and the gradient magnetic field unit to achieve parallel excitation and synchronous reception of at least two different nuclides.

2. The multi-nuclear magnetic resonance scanning device according to claim 1, wherein: The multi-nuclide radio frequency receiving unit includes a parallel processing unit for digitally processing the received echo signal.

3. The multi-nuclear magnetic resonance scanning device according to claim 2, wherein: The parallel processing unit includes a plurality of independent processing cores, and each of the processing cores is responsible for executing the digital processing of the echo signal of a nuclear species.

4. The multi-nuclear magnetic resonance scanning device according to claim 2, wherein: The parallel processing unit includes: At least two separate radio frequency receiving channels, each of which receives an echo signal of a nuclear species and performs digital processing; The radio frequency receiving channel at least comprises a receiving signal processing module (30), a filtering and frequency conversion processing module (40), and an acquisition control module (70).

5. The multi-nuclear magnetic resonance scanning device according to claim 4, wherein: The filtering and frequency conversion processing module (40) is connected to the received signal processing module (30) and is used to perform filtering and frequency conversion processing on the digital signal according to the filtering coefficient and frequency conversion parameter corresponding to each nuclide to obtain the signal to be imaged.

6. The multi-nuclear magnetic resonance scanning device according to claim 5, characterized in that: The filtering and frequency conversion processing module (40) comprises: An extraction module (430) is used to extract data from the frequency conversion signal to obtain the signal to be imaged; A communication analysis module (440) is used to send the radio frequency coil identifier to the digital filtering module (410) and the down-conversion processing module (420) to determine the filter coefficient and the frequency conversion parameter corresponding to each nuclide; The communication analysis module (440) is connected to the extraction module (430) and is used to obtain the signal to be imaged corresponding to each nuclide.

7. The multi-nuclear magnetic resonance scanning device according to claim 1, wherein: The multi-nuclide radio frequency transmitting unit includes: At least two separate radio frequency transmission modules (10), each of the radio frequency transmission modules (10) is connected to the control unit (60) and the radio frequency coil module (20), and is used to transmit a radio frequency signal of a corresponding nuclide to the radio frequency coil module (20) according to the sequence timing.

8. The multi-nuclear magnetic resonance scanning device according to claim 7, wherein: Each of the radio frequency transmission modules (10) comprises: A radio frequency signal generating module (110), connected to the control unit (60), for generating a digital pulse signal for each nuclide according to the sequence timing and the radio frequency coil identifier; A transmission signal processing module (120) is connected to the radio frequency signal generating module (110) and is used to process the digital pulse signal to obtain a radio frequency signal corresponding to each nuclide.

9. The multi-nuclear magnetic resonance scanning device according to any one of claims 1 to 8, characterized in that: The control unit (60) is connected to an acquisition control module (70), and the acquisition control module (70) is used to obtain the sequence timing and the radio frequency coil identifier, and control the synchronous reception of the reception signal processing module (30) according to the sequence timing; The control unit (60) is connected to the radio frequency transmission module (10) and is used to send the radio frequency coil identification to the radio frequency transmission module (10) and control the parallel excitation of the radio frequency transmission module (10) according to the sequence timing.

10. A multi-nuclear magnetic resonance imaging method, characterized in that: include: Based on the imaging parameters of the multi-nuclear magnetic resonance scan, controlling the multi-nuclide radio frequency transmitting unit to generate radio frequency signals of at least two different nuclides; The gradient magnetic field unit provides the gradient magnetic field required for spatial encoding; The multi-nuclide radio frequency receiving unit receives the echo signals of the different nuclides; The control unit adjusts the sequence timing of the multi-nuclide radio frequency transmitting unit, the multi-nuclide radio frequency receiving unit and the gradient magnetic field unit; The adjustment of the sequence timing realizes the parallel excitation of at least two different nuclides in the multi-nuclide radio frequency transmitting unit and the synchronous reception of at least two different nuclides by the multi-nuclide radio frequency receiving unit.

11. The multi-nuclear magnetic resonance imaging method according to claim 10, wherein: The adjustment of the sequence timing includes adjusting the timing based on a preset transceiver mode; wherein the transceiver mode includes at least one or more of: an independent mode, a synchronous mode, a nuclear Overhauser effect mode, and a decoupling mode.

12. The multi-nuclear magnetic resonance imaging method according to claim 10, wherein: The parallel excitation of at least two different nuclides in the multi-nuclide radio frequency emission unit comprises: A radio frequency signal that simultaneously excites at least two different nuclides; or The radio frequency signal of at least two different nuclides is excited in a time-sharing manner.

13. The multi-nuclear magnetic resonance imaging method according to claim 10, wherein: The multi-nuclide radio frequency receiving unit synchronously receives at least two different nuclides, including: The echo signals of different nuclides enter the parallel processing unit at the same time and perform digital processing synchronously.

14. A computer-readable storage medium storing a computer program, characterized in that: When the computer program is executed by a processor, the method according to any one of claims 10 to 13 is implemented.

Images