Tumor sample safe sampling device

Abstract

The invention discloses a tumor sample safe sampling device, and relates to the technical field of medical instruments, the tumor sample safe sampling device comprises a suction pipe, the suction pipe is a cylindrical pipe, the top of the suction pipe is fixedly provided with a suction pump, the bottom end of the suction pipe is fixedly provided with a sleeve, the output end of the suction pump is detachably fixedly provided with a suction pipe, and the suction pipe is used for being inserted into tumor tissue for sampling; the cannula is not in contact with cancer cells, can be repeatedly used and is made of medical-grade polycarbonate, and the inner wall is smooth and easy to clean and disinfect; a small ball is arranged in the suction pipe, and the small ball is released into the suction pipe after the suction of the device is completed and is used for judging whether sample liquid at the bottom in the pipe flows out or not after the suction by observing the position of the small ball; the technical effects that the sampling amount stability is improved, the sample liquid leakage risk is reduced, the sampling reliability and safety are improved, and follow-up detection is facilitated can be achieved.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to a safe tumor sample sampling device. Background Art

[0002] The tumor sample safety sampling device is a medical device specifically used to safely and effectively collect tumor tissue from the patient's body. It is designed to minimize damage to surrounding normal tissues during the sampling process while avoiding the spread and contamination of cancer cells.

[0003] Regarding tumor sample collection, Chinese invention patent publication number CN117357168B discloses a tumor detection sampling device comprising: a cylindrical tube with an extraction space at its bottom, an insertion tube fixedly connected to the bottom of the tube; multiple sample storage assemblies fixedly mounted in a ring on the side of the tube, comprising a mounting tube and a storage tube, the mounting tube fixedly connected to the side of the tube, the inlet end of the storage tube being threadedly connected to the tube end of the mounting tube; an extraction assembly disposed at the upper end of the tube for extracting tumor tissue into the storage tube, the extraction assembly comprising a guide block rotatably mounted within the mounting tube, an extraction port defined in the middle of the guide block, and a material guide port defined on the side of the extraction port, the material guide port being coplanar with the connection end of the mounting tube. This invention facilitates the extraction of multiple sets of samples in a single sampling process, improving sampling efficiency.

[0004] Although the above scheme improves the sampling efficiency to a certain extent when sampling tumor samples, in actual use, since the existing method is mainly based on manual aspiration, it may lead to unstable sampling volume and affect the accuracy of sampling. In addition, after the in vivo sampling is completed, due to its own gravity or the pressure in the tube just after the sampling is taken from the body, the sample liquid in the tube flows downward, causing leakage of the sample liquid, which may lead to contamination of the sample, reduce the reliability and safety of the sampling, and affect the accuracy of subsequent test results. Summary of the Invention

[0005] This application solves the technical problems in the prior art of unstable sampling volume, increased risk of sample liquid leakage, reduced reliability and safety of sampling, and disadvantages for subsequent detection by providing a safe tumor sample sampling device. It achieves the technical effects of improved sampling volume stability, reduced risk of sample liquid leakage, improved reliability and safety of sampling, and disadvantages for subsequent detection.

[0006] The present application provides a tumor sample safety sampling device, comprising a suction tube, which is a cylindrical tube with a suction pump fixed at the top and a sleeve fixed at the bottom. The suction tube is detachably fixed to the output end of the suction pump, and the suction tube is used to be inserted into tumor tissue for sampling; The sleeve does not contact cancer cells and can be used multiple times. It is made of medical-grade polycarbonate, and the inner wall is smooth and easy to clean and disinfect. A small ball is set inside the suction tube. The ball is released into the tube after the device completes the extraction. It is used to determine whether the sample liquid at the bottom of the tube has flowed out after extraction by observing the position of the ball.

[0007] Furthermore, the diameter of the sleeve is 3 to 5 mm; the diameter of the suction tube is 2 to 3 mm.

[0008] Furthermore, the suction pipe is provided with three sections, which are an upper section pipe, a soft tube and a lower section pipe from top to bottom; The upper section of the pipe is detachably fixed to the output end of the suction pump; the lower section of the pipe is fixed below the upper section of the pipe by a clamping method; the hose is a hollow tubular structure, the upper end of which is fixed to the outside of the upper section of the pipe by a fixing ring, and the lower end of which is fixed to the outside of the lower section of the pipe by a fixing ring.

[0009] Furthermore, the hose is a flexible structure and is made of rubber. In the initial state, when the upper section of the hose and the lower section of the hose are clamped, the hose is squeezed to form a ring structure and is sleeved on the outside of the suction tube. A small ball is provided between the hose and the suction tube to determine whether the sample liquid in the lower section of the hose has leaked and to display the amount of sample liquid extracted.

[0010] Furthermore, an electromagnet is embedded inside the sleeve at a position corresponding to the clamping connection. The fixing ring located below is made of iron and cooperates with the electromagnet to control the clamping connection between the upper tube and the lower tube by controlling the power supply of the electromagnet, thereby controlling the release of the ball.

[0011] Furthermore, a valve 1 is provided above the clamping part of the upper tube, which is used to cooperate with the ball and block the valve 1 through the movement of the ball to maintain a stable negative pressure in the lower tube and prevent the sample liquid inside the lower tube from flowing out.

[0012] Furthermore, a valve 2 is provided below the clamping point of the upper tube section, which is used to form a limited space with the valve 1, so that after the ball is released, it is always between the valve 1 and the valve 2, and the pressure in the lower tube section is maintained stable through the segmented pressure stabilization method.

[0013] Furthermore, the valve 1 and the valve 2 are both sac structures, and paraffin is provided inside them.

[0014] Furthermore, semiconductor refrigeration plates are provided on the outside of the upper and lower tubes and at positions corresponding to valves one and two. Through the action of the semiconductor refrigeration plates, valves one and two become hardened, and cooperate with the small balls to stabilize the pressure inside the lower tube.

[0015] Furthermore, the semiconductor refrigeration plate is a flexible structure, and its thickness is 0.8 to 1.0 mm.

[0016] One or more technical solutions provided in this application have at least the following technical effects or advantages: The connection and separation of the suction tube are controlled by an electromagnet, thereby realizing automation and precise control of the suction process; the cannula can be used multiple times without contacting cancer cells, and the suction tube is used once, thereby effectively reducing the risk of cross infection; by introducing a combination of the cannula, the suction tube and the ball 232, and performing a short period of negative pressure suction again after sampling, the risk of leakage caused by tissue fluid or cancer cells flowing out of the bottom of the tube mouth after sampling is effectively reduced, and the technical problems in the prior art of unstable sampling volume, increased risk of sample liquid leakage, reduced reliability and safety of sampling, and disadvantageous for subsequent detection are effectively solved, and the technical effects of improved sampling volume stability, reduced risk of sample liquid leakage, improved reliability and safety of sampling, and favorable for subsequent detection are achieved. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 This is a schematic diagram of the overall structure of a tumor sample safety sampling device of the present invention.

[0018] Figure 2 This is a schematic diagram of the partial three-dimensional structure of a tumor sample safety sampling device of the present invention.

[0019] Figure 3 This is a partial three-dimensional cross-sectional view of the cannula and suction tube of a tumor sample safety sampling device of the present invention.

[0020] Figure 4 A tumor sample safety sampling device of the present invention Figure 3 A partial enlarged schematic diagram of point A in the middle.

[0021] Figure 5 This is a longitudinal full-section view of the soft sleeve of a tumor sample safety sampling device of the present invention during sampling.

[0022] Figure 6 This is a full cross-sectional view of the soft cover of a tumor sample safety sampling device of the present invention when it is unfolded and releases the ball after sampling.

[0023] Figure 7 This is a full cross-sectional view of a tumor sample safety sampling device according to the present invention when negative pressure suction is performed again after sampling.

[0024] Figure 8 This is a partial three-dimensional cross-sectional view of the valve 1 of a tumor sample safety sampling device of the present invention.

[0025] In the figure: 100, suction tube; 110, sleeve; 120, suction pump; 200, suction tube; 210, upper section tube; 220, lower section tube; 230, hose; 231, fixing ring; 232, small ball; 240, electromagnet; 250, valve 1; 260, valve 2; 270, semiconductor refrigeration plate; 280, paraffin. DETAILED DESCRIPTION

[0026] To facilitate understanding of the present invention, the present application will be described more comprehensively below with reference to the relevant drawings; the drawings show preferred embodiments of the present invention, but the present invention can be implemented in many different forms and is not limited to the embodiments described herein; on the contrary, the purpose of providing these embodiments is to enable a more thorough and comprehensive understanding of the disclosed content of the present invention.

[0027] It should be noted that the terms “vertical”, “horizontal”, “up”, “down”, “left”, “right” and similar expressions used in this document are for illustrative purposes only and do not represent the only implementation method.

[0028] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by those skilled in the art to which this invention pertains; the terms used herein in the specification of the present invention are for the purpose of describing specific embodiments only and are not intended to limit the present invention; the term "and / or" used herein includes any and all combinations of one or more of the associated listed items.

[0029] See also Figure 1 , which is a schematic diagram of the overall structure of a tumor sample safety sampling device of the present invention; the tumor sample safety sampling device of the present invention controls the engagement and separation of the suction tube by an electromagnet, thereby realizing the automation and precise control of the suction process; the cannula can be used multiple times without contacting cancer cells, and the suction tube is used once, effectively reducing the risk of cross infection; by introducing a combination of the cannula, the suction tube and the small ball, and performing a short negative pressure suction again after the sampling, the risk of leakage caused by tissue fluid or cancer cells flowing out of the bottom of the tube after sampling is effectively reduced; the technical effects of improving the stability of the sampling volume, reducing the risk of sample liquid leakage, improving the reliability and safety of sampling, and facilitating subsequent detection are achieved.

[0030] Example 1: Figures 1 to 6 As shown, the present application provides a tumor sample safety sampling device, comprising a suction tube 100. The suction tube 100 is a cylindrical tube with a suction pump 120 fixed at the top and a sleeve 110 fixed at the bottom. The output end of the suction pump 120 is detachably fixed with a suction tube 200, which is used to be inserted into tumor tissue for sampling. The sleeve 110 does not contact cancer cells and can be used multiple times. It is made of medical-grade polycarbonate, and the inner wall is smooth and easy to clean and disinfect. A small ball 232 is set inside the suction tube 200. The small ball 232 is released into the tube after the device is extracted. By observing the position of the small ball 232, it is determined whether the sample liquid at the bottom of the tube has flowed out after extraction.

[0031] The diameter of the sleeve 110 is 3 to 5 mm; the diameter of the suction tube 200 is 2 to 3 mm.

[0032] The suction pipe 200 is provided with three sections, which are an upper section pipe 210, a hose 230 and a lower section pipe 220 from top to bottom; The upper tube section 210 is detachably fixed to the output end of the suction pump 120; The lower tube section 220 is fixed below the upper tube section 210 by means of a snap connection; The hose 230 is a hollow tubular structure, with its upper end fixed to the outside of the upper tube section 210 via a fixing ring 231 , and its lower end fixed to the outside of the lower tube section 220 via a fixing ring 231 .

[0033] The hose 230 is a flexible structure made of rubber. In the initial state, when the upper tube section 210 and the lower tube section 220 are clamped, the hose 230 is squeezed to form a ring structure and is sleeved on the outside of the suction tube 200. A small ball 232 is provided between the hose 230 and the suction tube 200 to determine whether the sample liquid in the lower tube section 220 has leaked and to display the amount of sample liquid extracted.

[0034] An electromagnet 240 is embedded inside the sleeve 110 at a position corresponding to the clamping connection. The fixing ring 231 located below is made of iron and cooperates with the electromagnet 240 to control the clamping connection between the upper tube 210 and the lower tube 220 by controlling the power supply of the electromagnet 240, thereby controlling the release of the ball 232.

[0035] The sleeve 110 and the suction tube 200 are both made of transparent material; the semiconductor cooling plate 270 is used to adjust the hardness of valve 1 250 and valve 2 260, and is preferably a TE Technology CP series; the suction pump 120 is used to drive the suction tube 200 to suction tumor samples in the human body through negative pressure, and is preferably a plunger pump; all of these are existing technologies and will not be described in detail here.

[0036] In actual operation, the embodiment of the present application comprises the following steps: first, the suction tube 200 is detachably fixed to the output end of the suction pump 120, and the electromagnet 240 is energized. The upper tube 210 and the lower tube 220 are connected together by magnetic attraction. At the same time, the ball 232 is squeezed between the hose 230 and the suction tube 200; then, the suction pump 120 is started to perform negative pressure suction to draw the tumor tissue fluid into the suction tube 200. When the sampling is completed, the suction tube 200 is moved to the suction tube 200. Pull out the suction tube 200 and turn off the power to the electromagnet 240 to separate the upper tube 210 from the lower tube 220, releasing the ball 232. Finally, to prevent leakage of the sample liquid, start the suction pump 120 to continue to apply negative pressure and suck the sample liquid in the tube upward a little. The ball 232 moves upward and blocks the valve 1 250, keeping the pressure in the lower tube 220 stable. After the sampling is completed, the device is cleaned and disinfected, and the suction tube 200 is replaced in preparation for the next sampling operation.

[0037] The technical solutions in the above embodiments of the present application have at least the following technical effects or advantages: The present application controls the engagement and separation of the suction tube 200 through the electromagnet 240, thereby realizing automation and precise control of the suction process, and improving the stability of the suction volume and the accuracy of sampling; the sleeve 110 can be used multiple times without contacting cancer cells, and the suction tube 200 is used once, which effectively reduces the risk of cross infection; by introducing the design of the sleeve 110 and the suction tube 200, especially the combination of the hose 230 and the ball 232, and performing a short period of negative pressure suction again after sampling, the risk of leakage caused by tissue fluid or cancer cells flowing out of the bottom of the tube mouth after sampling is effectively reduced, ensuring the integrity and safety of the sample and reducing the risk of contamination; the movement of the ball 232 can show how much the suction tube 200 continues to draw upward, which helps medical staff to control the sampling volume more accurately and improves the flexibility of the device; the technical effects of improving the stability of the sampling volume, reducing the risk of sample liquid leakage, improving the reliability and safety of sampling, and being beneficial to subsequent detection are achieved.

[0038] Example 2: In order to further improve the stability of the sample liquid pressure in the lower tube 220, the present application proposes the following technical solutions to address the above technical problems, specifically: like Figures 3 to 5 As shown, a valve 250 is provided above the clamping part of the upper tube 210 for cooperating with the ball 232 and sealing the valve 250 by moving the ball 232 to maintain a stable negative pressure in the lower tube 220 and prevent the sample liquid in the lower tube 220 from flowing out.

[0039] The present application sets a valve 250 similar to a one-way valve to allow fluid sample liquid to flow in a specific direction. When the ball 232 moves and blocks the valve 250, it can prevent the sample liquid in the upper tube 210 from flowing into the lower tube 220, effectively maintaining the negative pressure state in the upper tube 210, avoiding the sample liquid from flowing out due to pressure changes, and ensuring the accuracy and safety of sampling; the cooperation mechanism of valve 250 and ball 232 is adopted to achieve a fast-response blocking effect. When the ball 232 is moved to a specific position by the negative pressure of the suction pump 120, it can quickly block the valve 250 without the need for complicated mechanical operations or waiting time, thereby improving the efficiency of sampling, enabling medical staff to complete the sampling process more quickly, and reducing the waiting time and discomfort of patients.

[0040] Example 3: During the sampling process, due to human error or machine failure, the pressure in the tube may be unstable, causing the ball 232 to leak from the bottom of the lower tube 220, resulting in sample leakage. To address the above technical problems, this application proposes the following technical solutions, specifically: like Figures 5 to 7 As shown, a valve 260 is provided below the clamping point of the upper tube 210 to form a limited space with the valve 1 250, so that after the ball 232 is released, it is always between the valve 1 250 and the valve 2 260, and the pressure in the lower tube 220 is maintained stable through the segmented pressure stabilization method.

[0041] The valve 1 250 and the valve 2 260 are used to control the unidirectional flow of fluid (such as blood, liquid or gas), and are made of thermoplastic elastomer material. They are existing technologies and will not be described in detail here.

[0042] The present application utilizes the design of valve 260 to enable ball 232 to be quickly and accurately positioned between valve 1 250 and valve 2 260 after release, ensuring a reliable occlusion effect. Through a segmented pressure stabilization method, valve 1 250 and valve 2 260 work together, with ball 232 forming a dynamic sealing point between them, ensuring accurate and reliable occlusion, effectively preventing sample liquid leakage, and maintaining a stable pressure within lower tube 220. This is crucial for ensuring a smooth sampling process and avoiding problems such as unstable sampling volume or sample liquid leakage caused by pressure fluctuations. Because ball 232 is always located between valve 1 250 and valve 2 260, the dual-valve structure (valve 1 250 and valve 2 260) and the positioning mechanism of ball 232 enable more precise control of pressure changes during the sampling process, thereby improving sampling accuracy. Furthermore, the dual-valve design accommodates a wider negative pressure range, meeting the sampling requirements of different tumor tissues and reducing the impact of human error.

[0043] Example 4: In order to improve the pressure stabilization effect of the sample liquid in the tube, meet the anatomical structures or sampling requirements of different patients, and improve the flexibility of the device, the present application proposes the following technical solutions to address the above technical problems, specifically: like Figures 5 to 8 As shown, the valve 1 250 and the valve 2 260 are both sac structures, and paraffin 280 is provided inside them.

[0044] Semiconductor refrigeration sheets 270 are provided on the outside of the upper tube section 210 and the lower tube section 220 and at the positions corresponding to valve 1 250 and valve 2 260. The semiconductor refrigeration sheets 270 harden valve 1 250 and valve 2 260 and cooperate with the small ball 232 to stabilize the pressure inside the lower tube section 220.

[0045] The semiconductor cooling sheet 270 is a flexible structure with a thickness of 0.8 to 1.0 mm.

[0046] The semiconductor cooling sheet 270 is used to adjust the hardness of the valve 1 250 and the valve 2 260, and is preferably a TETechnology CP series. It is a prior art and will not be described in detail here.

[0047] The present application allows valve one 250 and valve two 260 to undergo elastic deformation when subjected to force while maintaining the integrity of the overall structure through the capsule design; by adjusting the temperature of valve one 250 and valve two 260 through the semiconductor refrigeration plate 270, the hardness of paraffin 280 can be controlled in real time to adapt to different suction pressure requirements; at the same time, through the hardening effect of paraffin 280, valve one 250 and valve two 260 can maintain their shape more stably during negative pressure suction, preventing sealing failure caused by pressure fluctuations; by enhancing the rigidity of valve one 250 and valve two 260, deformation caused by fluid pressure is reduced; the synergistic effect of the double valve structure and paraffin 280 can form a multi-level sealing barrier to effectively prevent leakage of sample liquid.

[0048] The foregoing description is merely a preferred embodiment of the present invention and is not intended to limit the present invention. Various modifications and variations are readily apparent to those skilled in the art. Any modifications, equivalent substitutions, or improvements made within the spirit and principles of the present invention shall be included within the scope of protection of the present invention.

Claims

1. A tumor sample safety sampling device, characterized in that: The suction tube (100) is a cylindrical tube with a suction pump (120) fixed on the top and a sleeve (110) fixed on the bottom. The suction tube (200) is fixed on the output end of the suction pump (120) in a detachable manner. The suction tube (200) is used to be inserted into tumor tissue for sampling. The sleeve (110) does not contact cancer cells and can be used multiple times. It is made of medical-grade polycarbonate and has a smooth inner wall that is easy to clean and disinfect. A small ball (232) is provided inside the suction tube (200). The small ball (232) is released into the tube after the device completes extraction, and is used to determine whether the sample liquid at the bottom of the tube after extraction has flowed out by observing the position of the small ball (232).

2. A tumor sample safety sampling device according to claim 1, characterized in that: The diameter of the sleeve (110) is 3 to 5 mm; the diameter of the suction tube (200) is 2 to 3 mm.

3. The tumor sample safety sampling device according to claim 1, characterized in that: The suction pipe (200) is provided with three sections, which are, from top to bottom, an upper section pipe (210), a hose (230), and a lower section pipe (220); The upper tube section (210) is detachably fixed to the output end of the suction pump (120); the lower tube section (220) is fixed below the upper tube section (210) by means of a snap connection; the hose (230) is a hollow tubular structure, the upper end of which is fixed to the outside of the upper tube section (210) by means of a fixing ring (231), and the lower end of which is fixed to the outside of the lower tube section (220) by means of a fixing ring (231).

4. A tumor sample safety sampling device according to claim 3, characterized in that: The hose (230) is a flexible structure and is made of rubber. In the initial state, when the upper tube (210) and the lower tube (220) are clamped, the hose (230) is squeezed to form a ring structure and is sleeved on the outside of the suction tube (200). A small ball (232) is provided between the hose (230) and the suction tube (200) for determining whether the sample liquid in the lower tube (220) has leaked and displaying the amount of sample liquid extracted.

5. The tumor sample safety sampling device according to claim 4, characterized in that: An electromagnet (240) is embedded inside the sleeve (110) at a position corresponding to the clamping connection. The fixing ring (231) located below is made of iron and cooperates with the electromagnet (240) to control the clamping connection between the upper tube (210) and the lower tube (220) by controlling the power supply of the electromagnet (240), thereby controlling the release of the ball (232).

6. The tumor sample safety sampling device according to claim 5, characterized in that: A valve 1 (250) is provided above the clamping portion of the upper tube section (210) for cooperating with the small ball (232) and sealing the valve 1 (250) by the movement of the small ball (232), thereby maintaining a stable negative pressure in the lower tube section (220) and preventing the sample liquid inside the lower tube section (220) from flowing out.

7. The tumor sample safety sampling device according to claim 6, characterized in that: A second valve (260) is provided below the clamping portion of the upper tube section (210) for forming a confined space with the first valve (250), so that after the ball (232) is released, it is always located between the first valve (250) and the second valve (260), and the pressure in the lower tube section (220) is maintained stable by a segmented pressure stabilization method.

8. The tumor sample safety sampling device according to claim 7, characterized in that: The valve 1 (250) and the valve 2 (260) are both sac structures, and paraffin (280) is provided inside them.

9. The tumor sample safety sampling device according to claim 8, characterized in that: Semiconductor cooling sheets (270) are provided on the outer sides of the upper tube section (210) and the lower tube section (220) and at locations corresponding to the first valve (250) and the second valve (260). The semiconductor cooling sheets (270) harden the first valve (250) and the second valve (260) and cooperate with the small ball (232) to stabilize the pressure inside the lower tube section (220).

10. The tumor sample safety sampling device according to claim 9, characterized in that: The semiconductor refrigeration sheet (270) is a flexible structure, and its thickness is between 0.8 and 1.0 mm.

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