Traditional Chinese medicine composition for treating carotid atherosclerosis and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine composition for treating carotid atherosclerosis and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine compositions.The traditional Chinese medicine composition is prepared from, by mass, 20 g of semen ziziphi spinosae, 15 g of rhizoma curcumae longae, 10 g of myrrh, 10 g of radix notoginseng, 20 g of radix salviae miltiorrhizae, 15 g of ground beetles, 10 g of gadflies, 5 g of edible tulip, 15 g of radix cyathulae and 30 g of uniflower swisscentaury roots. The preparation method comprises the following steps: S1, decocting, namely decocting the medicinal components according to the mass ratio for three times, adding water which is 5 times of the mass of the medicinal components each time, and decocting for 45 minutes; s2, filtering: filtering by using a 120-mesh filter screen to obtain a filtrate; s3, concentration: concentrating the filtrate into thick extract with the relative density of 1.15 times; s4, performing granulation: adding dextrin and 0.1% stevioside, performing boiling granulation, and controlling the water content to be within 5%; s5, sub-packaging: sub-packaging one dose into 12 small bags; the invention provides a traditional Chinese medicine composition for treating carotid atherosclerosis, which can nourish and activate blood, soften hardness to dissipate stagnation and dredge vessels to remove blood stasis, so as to treat carotid atherosclerosis by treating both blood and vessels.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine compositions, and in particular to a traditional Chinese medicine composition for treating carotid atherosclerosis and a preparation method thereof. Background Art

[0002] Carotid atherosclerosis, a warning "window" for systemic atherosclerosis, has long been considered a high-risk factor for cardiovascular and cerebrovascular diseases. Therefore, the present invention aims to effectively intervene in the formation of carotid atherosclerosis, slowing or even reversing its progression, and reducing the risk of cardiovascular and cerebrovascular diseases.

[0003] Lipid regulation remains the core of the treatment of carotid atherosclerosis. Statins, as the first choice of clinical treatment, can effectively lower total cholesterol and low-density lipoprotein levels, but long-term use can cause adverse reactions such as muscle soreness and abnormal liver function. More importantly, statins have limited efficacy in reversing or eliminating plaque growth, with an efficiency of only 8%, resulting in many patients still facing the risk of developing arterial stenosis or occlusion. For patients with moderate to severe arterial stenosis, surgical interventions such as carotid endarterectomy and carotid stenting are often used. However, complications caused by surgical treatment and the risk of restenosis and thrombosis after surgery restrict its clinical application. Therefore, exploring safer, more effective, and body-friendly anti-atherosclerotic methods and drugs is an urgent clinical need. Summary of the Invention

[0004] The present invention aims to provide a traditional Chinese medicine composition for treating carotid atherosclerosis and a preparation method thereof, so as to solve the problems raised in the above background technology.

[0005] In order to achieve the above object, the present invention provides the following technical solutions:

[0006] A traditional Chinese medicine composition for treating carotid atherosclerosis comprises the following components by mass: 20g of spinach seed, 15g of turmeric, 10g of myrrh, 10g of Panax notoginseng, 20g of salvia miltiorrhiza, 15g of earthworm, 10g of horsefly, 5g of Trillium, 15g of Cyathula, and 30g of Rhizoma Cyperi.

[0007] A method for preparing a traditional Chinese medicine composition for treating carotid atherosclerosis, comprising:

[0008] S1, decoction, after completing the mass ratio of each drug component, decoct 3 times, adding 5 times the mass of water each time, and decoct for 45 minutes;

[0009] S2, filtering, using a 120-mesh filter screen to obtain a filtrate;

[0010] S3, concentrating, concentrating the filtrate to a thick extract with a relative density of 1.15 times;

[0011] S4. Granulation: Add dextrin and 0.1% stevioside, and perform boiling granulation, controlling the moisture content within 5%.

[0012] S5. Sub-packaging: Sub-package into 12 small bags per dose.

[0013] Compared with the prior art, the present invention has the following beneficial effects:

[0014] The present invention provides a traditional Chinese medicine combination for treating carotid atherosclerosis, which can nourish blood and activate blood circulation, soften hardness and disperse nodules, dredge meridians and remove stasis, achieving the treatment of both blood and meridians and treating carotid atherosclerosis. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 It is a flow chart of the preparation method of a traditional Chinese medicine composition for treating carotid atherosclerosis. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0016] The following further elaborates the present invention in detail in conjunction with the drawings and embodiments:

[0017] A traditional Chinese medicine composition for treating carotid atherosclerosis, with each component calculated by mass as follows: 20 g of Semen Ziziphi Spinosae, 15 g of Curcuma longa, 10 g of Myrrha, 10 g of Panax notoginseng, 20 g of Salvia miltiorrhiza, 15 g of Eupolyphaga seu Steleophaga, 10 g of Tabanus, 5 g of Cremastra appendiculata, 15 g of Cyathula officinalis, and 30 g of Rhaponticum uniflorum.

[0018] The pharmacological effects of each medicinal material are as follows:

[0019] Semen Ziziphi Spinosae and Cremastra appendiculata are the monarch drugs, following the principle of "one tonifying and one eliminating". The two drugs are used in combination. One is to nourish the blood essence by the combination of sour and sweet flavors, and the other is to resolve phlegm and disperse nodules to remove the superficial symptoms, treating both the root cause and the symptoms. Eupolyphaga seu Steleophaga and Tabanus (Hirudo nipponica) are used for their property of searching and dredging of insect drugs, breaking blood and resolving stasis, dissipating phlegm and removing blood stasis. Together with Myrrha and Panax notoginseng, they enhance the effect of promoting blood circulation and removing blood stasis, and are all ministerial drugs to remove the superficial symptoms of "intermingled phlegm and blood stasis". "Salvia miltiorrhiza alone has the same effect as the four drugs for nourishing blood", which can not only cooperate with the monarch drug Semen Ziziphi Spinosae to nourish the blood and nourish the heart to treat the root cause, but also assist the ministerial drugs Eupolyphaga seu Steleophaga and Myrrha to promote blood circulation and remove blood stasis to treat the superficial symptoms. It is truly a good product for both tonifying and purging. The drug pair "Curcuma longa - Cyathula officinalis": Curcuma longa is pungent, warm, dispersing, reaching the qi aspect externally to promote qi and relieve depression, and entering the blood aspect internally to promote blood circulation and relieve pain; Cyathula officinalis is bitter, sweet, sour, and neutral, specifically entering the blood aspect, capable of promoting blood circulation and dredging menstruation, tonifying the liver and kidney, strengthening the tendons and bones, and especially good at guiding blood downward. The two drugs are combined, one qi and one blood, one ascending and one descending, jointly exerting the effects of promoting qi and blood circulation and regulating qi and blood, and also containing the profound meaning of "using both elimination and tonification". The assistant drug Rhaponticum uniflorum is used because when phlegm and blood stasis are intermingled for a long time, it is easy to transform into heat and generate toxins. Taking the bitter and cold property of Rhaponticum uniflorum, it can not only clear heat and detoxify to remove stagnant heat, but also promote blood circulation and dredge meridians to assist the medicinal power. It is truly an important drug for the syndrome of phlegm and blood stasis transforming into heat. When all the drugs are combined, they treat both blood and meridians, nourish blood and activate blood circulation, soften hardness and disperse nodules, dredge meridians and remove stasis, and can effectively inhibit atherosclerosis and prevent the progression of the disease.

[0020] Such as Figure 1As shown, a method for preparing a traditional Chinese medicine composition for treating carotid atherosclerosis comprises:

[0021] S1, decoction, after completing the mass ratio of each drug component, decoct 3 times, adding 5 times the mass of water each time, and decoct for 45 minutes;

[0022] S2, filtering, using a 120-mesh filter screen to obtain a filtrate;

[0023] S3, concentrating, concentrating the filtrate to a thick extract with a relative density of 1.15 times;

[0024] S4, granulation, adding dextrin and 0.1% steviol glycosides, boiling granulation, controlling the moisture content within 5%;

[0025] S5. Divide into 12 small bags per dose.

[0026] The specific implementation process is as follows:

[0027] Typical Case 1

[0028] The patient, a 52-year-old male, was first diagnosed on August 16, 2023.

[0029] Chief complaint: Carotid artery plaque was discovered 8 months ago. The patient was diagnosed with carotid artery plaque during a physical examination at another hospital 8 months ago and received no treatment. Current medical history: no special discomfort, normal diet, bowel movements and urination. Past medical history: hyperlipidemia, taking atorvastatin calcium.

[0030] Physical examination: body temperature 36.5℃, heart rate 78 beats / min, respiratory rate 20 breaths / min, blood pressure 130 / 80 mmHg, tongue and pulse: pale red tongue with thin white fur, stringy pulse; auxiliary examination: carotid artery color Doppler ultrasound: the diameter of the common carotid arteries, internal carotid arteries and external carotid arteries on both sides were not dilated or narrowed, the wall of the artery was not smooth, a 1.8*19.7mm uneven plaque was found in the left common carotid artery, and a 1.6*10mm uneven echo plaque was found in the right subclavian artery; routine blood test and liver and kidney function showed no obvious abnormalities.

[0031] Western medicine diagnosis: carotid artery plaque.

[0032] Traditional Chinese Medicine diagnosis: phlegm nodules; treatment principle: nourishing blood and activating blood circulation, softening and dispersing nodules, unblocking meridians and removing blood stasis; selected prescription: Huaban Tongmai Granules, composition: 20g of Ziziphus jujuba seed, 15g of Curcuma longa, 10g of Myrrha, 10g of Panax notoginseng, 20g of Salvia miltiorrhiza, 15g of Eupolyphaga sinensis, 10g of Horsetail flea market, 5g of Trillium, 15g of Cyathula capitata, 30g of Rhizoma Cyperi; take the above granules with boiled water, 150mL each time, 3 times a day, for a total of 42 doses.

[0033] Second visit (January 24, 2024): The patient had no special discomfort, and his diet and bowel movements were normal. Physical examination: body temperature 36.2℃, heart rate 64 beats / min, respiratory rate 20 breaths / min, blood pressure 124 / 80 mmHg. Tongue and pulse: The tongue was pale red with teeth marks on the edges, the tongue coating was thin and white, and the pulse was stringy. Auxiliary examination: Color Doppler ultrasound of the carotid artery: the thickness of the intima-media of the bilateral common carotid arteries was approximately 0.6mm; the intima-media of the posterior wall of the left common carotid artery bifurcation was locally thickened, with a length of approximately 10mm and a thicker part of approximately 1.3mm. Routine blood tests and liver and kidney function tests showed no obvious abnormalities. Western medicine diagnosis: carotid artery plaque. Traditional Chinese Medicine diagnosis: phlegm nodules; treatment principle: nourishing blood and activating blood circulation, softening and dispersing nodules, unblocking meridians and removing blood stasis; selected prescription: Huaban Tongmai Granules, composition: 20g of Ziziphus jujuba seed, 15g of Curcuma longa, 10g of Myrrha, 10g of Panax notoginseng, 20g of Salvia miltiorrhiza, 15g of Eupolyphaga sinensis, 10g of Horsetail flea market, 5g of Trillium, 15g of Cyathula capitata, 30g of Rhizoma Cyperi; take the above granules with boiled water, 150mL each time, 3 times a day, for a total of 42 doses.

[0034] Typical Case 2

[0035] The patient, a 71-year-old female, was first diagnosed on March 14, 2023.

[0036] Chief complaint: Carotid artery plaque was found more than a month ago. The patient was found to have carotid artery plaque during a physical examination in another hospital a month ago and was not treated; current medical history: palpitations, tinnitus, poor sleep, normal diet and bowel movements; past medical history: fatty liver, hypertriglyceridemia.

[0037] Physical examination: temperature 36.3°C, heart rate 72 beats / min, respiratory rate 20 breaths / min, blood pressure 133 / 82 mmHg; tongue and pulse: dark tongue with a thin, greasy, white coating, and a tight, stringy pulse; auxiliary examination: carotid ultrasound: medial thickening of the left common carotid artery 0.8 mm. Multiple mixed echogenic plaques, approximately 6.6 x 3.0 mm, were observed at the common carotid bifurcation.

[0038] Western medicine diagnosis: carotid artery plaque.

[0039] Traditional Chinese Medicine diagnosis: phlegm nodules; treatment principle: nourishing blood and activating blood circulation, softening and dispersing nodules, unblocking meridians and removing blood stasis; selected prescription: Huaban Tongmai Granules, composition: 20g of Ziziphus jujuba seed, 15g of Curcuma longa, 10g of Myrrha, 10g of Panax notoginseng, 20g of Salvia miltiorrhiza, 15g of Eupolyphaga sinensis, 10g of Horsetail flea market, 5g of Trillium, 15g of Cyathula capitata, 30g of Rhizoma Cyperi; take the above granules with boiled water, 150mL each time, 3 times a day, for a total of 42 doses.

[0040] On the second visit (August 9, 2023), the patient had no special discomfort, and his diet and bowel movements were normal. Physical examination: temperature 36.5°C, heart rate 75 beats / min, respiratory rate 20 breaths / min, blood pressure 124 / 80 mmHg. Tongue and pulse: dark tongue, thin white fur, and tight pulse. Auxiliary examination: Carotid artery color Doppler ultrasound: strong echo attachment was found on the wall of the left common carotid artery at the bifurcation, with the thickest part being approximately 2.1 mm. Routine blood tests and liver and kidney function tests showed no obvious abnormalities. Western medicine diagnosis: carotid artery plaque. Traditional Chinese Medicine diagnosis: phlegm nodules; treatment principle: nourishing blood and activating blood circulation, softening and dispersing nodules, unblocking meridians and removing blood stasis; selected prescription: Huaban Tongmai Granules, composition: 20g of Ziziphus jujuba seed, 15g of Curcuma longa, 10g of Myrrha, 10g of Panax notoginseng, 20g of Salvia miltiorrhiza, 15g of Eupolyphaga sinensis, 10g of Horsetail flea market, 5g of Trillium, 15g of Cyathula capitata, 30g of Rhizoma Cyperi; take the above granules with boiled water, 150mL each time, 3 times a day, for a total of 42 doses.

[0041] Carotid artery ultrasound is the gold standard for clinical assessment of carotid atherosclerosis. Six months after standardized treatment, follow-up carotid ultrasound examinations in the aforementioned patients revealed varying degrees of reduction in carotid plaque size. This objective imaging evidence fully confirms the significant anti-carotid atherosclerotic effect of this traditional Chinese medicine granule preparation.

[0042] The above is only an embodiment of the present invention, and the common knowledge such as the specific technical solutions and / or characteristics in the solution are not described in detail here. It should be pointed out that for those skilled in the art, without departing from the technical solution of the present invention, several variations and improvements can be made, which should also be regarded as the scope of protection of the present invention, and these will not affect the effect of the implementation of the present invention and the practicality of the patent. The scope of protection required by this application shall be based on the content of its claims, and the specific implementation methods and other records in the description can be used to interpret the content of the claims.

Claims

1. A Chinese medicine composition for treating carotid atherosclerosis, characterized in that: The components are calculated by mass as follows: 20g of Ziziphus jujuba seeds, 15g of turmeric, 10g of myrrh, 10g of Panax notoginseng, 20g of Salvia miltiorrhiza, 15g of Eupolyphaga sinensis, 10g of Gadfly, 5g of Trillium, 15g of Cyathula, and 30g of Rhizoma Cyperi.

2. A method for preparing a traditional Chinese medicine composition for treating carotid atherosclerosis, characterized in that: The method comprises: S1, decoction, after completing the mass ratio of each drug component, decoct 3 times, adding 5 times the mass of water each time, and decoct for 45 minutes; S2, filtering, using a 120-mesh filter screen to obtain a filtrate; S3, concentrating, concentrating the filtrate to a thick extract with a relative density of 1.15 times; S4, granulation, adding dextrin and 0.1% steviol glycosides, boiling granulation, controlling the moisture content within 5%; S5. Divide into 12 small bags per dose.

Images