Disposable glove and in-situ preparation method thereof

Abstract

The invention discloses an in-situ preparation method of disposable gloves, which is used for forming sodium alginate hydrogel disposable gloves on the surface of a human hand in situ, and the in-situ preparation method comprises the following steps: dissolving sodium alginate, a thickening agent and calcium carbonate powder in water to prepare a first solution; dissolving glucolactone in water to prepare a second solution; the first solution and the second solution are evenly mixed and then smeared on the surface of the hand, and after gel is formed, the disposable gloves made of the sodium alginate hydrogel are prepared in situ. According to the in-situ preparation method of the in-situ sodium alginate hydrogel disposable gloves, the forming process of the sodium alginate hydrogel is transferred to the surface of the human hand, so that the prepared gloves fit with the hand shape are convenient to use, and the sodium alginate hydrogel is degradable and environmentally friendly.

Description

[0001] This application is a divisional application of the invention patent application with the application date of July 28, 2022, application number 2022108983886, and invention name “In situ sodium alginate hydrogel disposable gloves and preparation method thereof”. Technical Field

[0002] The present invention belongs to the technical field of gloves, and in particular relates to an in-situ sodium alginate hydrogel disposable glove and an in-situ preparation method thereof. Background Art

[0003] Traditional disposable gloves are mostly plastic disposable gloves, latex disposable gloves, rubber disposable gloves, etc. They are low in price and easy to use. They are widely used in food, medical, chemical, electronics and other fields.

[0004] However, these gloves are typically manufactured using fixed molds. While available in various sizes, they can still be too large or too small, making them difficult to fit perfectly on all hands. Furthermore, conventional disposable gloves are mostly made of non-degradable materials like plastic and rubber, which poses a burden on the environment when manufactured and used in large quantities. Therefore, designing environmentally friendly disposable gloves that fit perfectly on the hand is of great significance. Summary of the Invention

[0005] In view of this, in order to overcome the shortcomings of the prior art, the purpose of the present invention is to provide an application of sodium alginate hydrogel in the in-situ preparation of disposable gloves and a specific preparation method, which can perfectly fit the shape of the hand, is easy to use, and the sodium alginate hydrogel is biodegradable and environmentally friendly.

[0006] In order to achieve the above object, the present invention adopts the following technical solutions:

[0007] The present invention provides application of sodium alginate hydrogel in in-situ preparation of disposable gloves.

[0008] The present invention also provides a disposable glove prepared based on the above application.

[0009] According to some preferred embodiments of the present invention, the disposable gloves are prepared by the following method:

[0010] Dissolve sodium alginate and a thickener in water to prepare a first solution; dissolve calcium chloride in water to prepare a second solution;

[0011] The first solution is evenly applied to the surface of the hand, and the second solution is sprayed onto the surface of the first solution, with the mass ratio of the first solution to the second solution being 1:1 to 1.1, to prepare a disposable glove containing sodium alginate hydrogel in situ. In some embodiments, the second solution can be sprayed onto the surface of the first solution. Upon contact between the two solutions, a hydrogel quickly forms on the contact surface, enveloping the entire hand and in close contact with the skin.

[0012] According to some preferred embodiments of the present invention, the disposable gloves are prepared by the following method:

[0013] Dissolving sodium alginate, thickener and calcium carbonate powder in water to prepare a first solution; dissolving gluconolactone in water to prepare a second solution;

[0014] The first solution and the second solution are mixed and applied to the hand surface, wherein the mass ratio of the first solution to the second solution is 1:1. After the gel is formed, the disposable gloves of sodium alginate hydrogel are prepared in situ. Gluconolactone will slowly hydrolyze and release H in aqueous solution. + , so that calcium carbonate dissolves and releases Ca 2+ This causes the sodium alginate to gel.

[0015] According to some preferred embodiments of the present invention, the viscosity of the first solution is 10,000 to 40,000 cps at 25°C.

[0016] According to some preferred embodiments of the present invention, the mass ratio of calcium chloride or calcium carbonate to sodium alginate is 0.3:1 to 0.8:1. Gloves produced within this ratio range achieve optimal strength. The essence of gel formation is the chemical reaction between calcium ions and sodium alginate. Too few calcium ions will result in insufficient gel strength, while too many will be limited by the amount of sodium alginate, halting the reaction.

[0017] According to some preferred embodiments of the present invention, the concentration of sodium alginate in the first solution is 1% to 5%.

[0018] According to some preferred embodiments of the present invention, the concentration of calcium chloride is 1% to 5%. If the concentration is too low, the gel strength is insufficient. Further increasing the calcium chloride concentration does not significantly change the gel properties, and adding too much will affect the final performance of the gloves. The mass concentration of calcium carbonate is 1% to 5%.

[0019] According to some preferred embodiments of the present invention, the concentration of gluconolactone in the second solution is calculated based on a mass ratio of gluconolactone to calcium carbonate of 1:2 to 1:6.

[0020] According to some preferred embodiments of the present invention, the thickener is a combination of one or more of carbomer, xanthan gum, sodium carboxymethyl cellulose, hydroxyethyl cellulose, polyethylene oxide, polyvinyl alcohol, and polyvinyl pyrrolidone. The thickener is a commonly used thickener in the cosmetics and daily chemical industries, and its function is to adjust the viscosity of the first solution so that it can evenly adhere to the surface of the hand and does not flow down, so that the apparent viscosity of the first solution is about 10,000 to 40,000 cps. If the viscosity is too low, the solution has good fluidity and cannot adhere to the surface of the hand. If the viscosity is too high, the time required to prepare the solution is too long, which reduces production efficiency and is inconvenient during use.

[0021] According to some preferred embodiments of the present invention, the first solution and / or the second solution contains a disinfectant, which is a combination of one or more of medical alcohol, quaternary ammonium salts, benzalkonium chloride, triclosan, and polyhexamethylene biguanide. Whether to add the disinfectant and the concentration to be added can be determined based on the intended use of the disposable gloves. For use in environments requiring antibacterial treatment, the disinfectant must at least reach a minimum inhibitory concentration.

[0022] The principle of the invention of this application is as follows: Sodium alginate is a heteropolysaccharide composed of β-1,4-D mannuronic acid (M) and α-1,4,-D guluronic acid (G), and its molecule contains rich -COO - When divalent cations are added to the aqueous solution of sodium alginate, the Na + It will exchange with these divalent cations to form a three-dimensional network structure, causing the sodium alginate solution to transform into a gel. 2+ With high chelating capacity and low biotoxicity, divalent cations are suitable for preparing sodium alginate hydrogels. During the transition from sodium alginate solution to gel, they are transferred to the hand surface, allowing for the in-situ preparation of hand-fitting disposable gloves.

[0023] Due to the implementation of the above technical solution, the present invention has the following advantages over the prior art: the in-situ preparation method of the sodium alginate hydrogel disposable gloves of the present invention transfers the formation process of the sodium alginate hydrogel to the surface of the human hand, so that the prepared sodium alginate hydrogel forms a glove that fits the shape of the hand, is easy to use, and the sodium alginate hydrogel is biodegradable and environmentally friendly. DETAILED DESCRIPTION

[0024] In order to enable those skilled in the art to better understand the technical solutions of the present invention, the technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts should fall within the scope of protection of the present invention.

[0025] Sodium alginate is a natural polysaccharide extracted from brown algae with excellent biocompatibility and biodegradability. Aqueous sodium alginate solutions readily combine with divalent cations to form gels. Based on this, the present invention provides an in-situ sodium alginate hydrogel disposable glove and its preparation method. These gloves are environmentally friendly, easy to use, and provide a perfect fit to the user's hand.

[0026] Depending on the usage mode (spraying or mixing and applying), the preparation method of the in-situ disposable gloves of the present invention has the following two forms (the concentrations mentioned below are by mass concentration by default):

[0027] The first preparation method comprises the following steps:

[0028] 1. Dissolve sodium alginate and thickener in water to prepare a first solution with a viscosity of 10,000 to 40,000 cps (25°C). The concentration of sodium alginate is 1% to 5%. If the concentration is too low, the gel layer will be too thin, while if it is too high, the solution viscosity will be too high, making it inconvenient to use.

[0029] 2. Dissolve calcium chloride and disinfectant in water to prepare a second solution. The calcium chloride concentration should be 1% to 5%. If the concentration is too low, the gel strength will be insufficient. Further increasing the calcium chloride concentration will not significantly change the gel properties, and adding too much will affect the final performance of the gloves. Different disinfectants require different concentrations, but at least the minimum inhibitory concentration (MIC) should be reached.

[0030] 3. During use, evenly apply the first solution to the hand surface, then spray the second solution onto the hand surface. This creates an in-situ sodium alginate hydrogel disposable glove. Upon contact, the two solutions quickly form a hydrogel on the contact surface, enveloping the entire hand and maintaining close contact with the skin.

[0031] Before use, it is best to clean and dry your hands to avoid severe dirt or excessive moisture that may affect the shaping and use of the gloves.

[0032] The second preparation method comprises the following steps:

[0033] 1. Dissolve and disperse sodium alginate, a thickener, calcium carbonate powder, and a disinfectant in water to prepare a first solution. The viscosity of the first solution is 10,000 to 40,000 cps (25°C). The mass concentration of sodium alginate is 1% to 5%. A lower concentration will result in a thin gel layer, while a higher concentration will result in excessive viscosity and inconvenience. The mass concentration of calcium carbonate is 1% to 5%. The required concentration varies for different disinfectants, but at least the minimum inhibitory concentration (MIC) is sufficient.

[0034] 2. Dissolve gluconolactone in water to prepare a second solution. The concentration of gluconolactone in the second solution is calculated based on a mass ratio of gluconolactone to calcium carbonate of 1:2 to 1:6. Gluconolactone will slowly hydrolyze and release H in aqueous solution. + , so that calcium carbonate dissolves and releases Ca 2+ This causes the sodium alginate to gel.

[0035] 3. When in use, mix the first solution and the second solution and apply them to the surface of the hand. After the gel is formed, the sodium alginate hydrogel disposable gloves are prepared in situ on the surface of the hand.

[0036] Thickeners are commonly used in the cosmetics and daily chemical industries, such as carbomer, xanthan gum, sodium carboxymethyl cellulose, hydroxyethyl cellulose, polyethylene oxide, polyvinyl alcohol, and polyvinyl pyrrolidone. They adjust the viscosity of the first solution, ensuring it adheres evenly to the hand surface and prevents runoff. Different thickener types generally require different concentrations, adjusting the apparent viscosity of the first solution to approximately 10,000 to 40,000 cps at 25°C. Disinfectants include medical alcohol, quaternary ammonium salts, benzalkonium chloride, triclosan, and polyhexamethylene biguanide. The required concentration varies depending on the disinfectant, but should at least reach the minimum inhibitory concentration.

[0037] The hydrogel prepared by the above method has a certain strength and contains disinfectant components. While being used as disposable gloves, it also has the effect of cleaning and disinfecting hands.

[0038] Example 1

[0039] The in-situ preparation of disposable gloves using sodium alginate hydrogel in this embodiment includes the following steps:

[0040] 1. Dissolve 3 g of sodium alginate and 0.8 g of thickener in 100 mL of water to prepare a first solution. The viscosity of the first solution is 28,000 cps (25° C.), wherein the concentration of sodium alginate is 2.9%.

[0041] 2. Dissolve 1.2g of calcium chloride and 0.2g of disinfectant in 100mL of water to prepare a second solution, where the concentration of calcium chloride is 1.2% and the concentration of disinfectant is 0.2%.

[0042] 3. When in use, evenly apply the first solution on the surface of the hand, and then spray the second solution on the surface of the hand in the form of a spray. The amount of the second solution is 1.1 times that of the first solution. That is, a sodium alginate hydrogel disposable glove is prepared in situ on the surface of the hand.

[0043] Example 2

[0044] The in-situ preparation of disposable gloves using sodium alginate hydrogel in this embodiment includes the following steps:

[0045] 1. Dissolve 2g of sodium alginate and 0.5g of thickener in 100mL of water to prepare a first solution. The viscosity of the first solution is 20,000 cps (25°C). The concentration of sodium alginate is 2%.

[0046] 2. Dissolve 1.4 g of calcium chloride and 0.2 g of disinfectant in 100 mL of water to prepare a second solution, where the concentration of calcium chloride is 1.4% and the concentration of disinfectant is 0.2%.

[0047] 3. When in use, evenly apply the first solution on the surface of the hand, and then spray the second solution on the surface of the hand in the form of a spray. The amount of the second solution is 1.05 times that of the first solution. That is, a sodium alginate hydrogel disposable glove is prepared in situ on the surface of the hand.

[0048] Example 3

[0049] The in-situ preparation of disposable gloves using sodium alginate hydrogel in this embodiment includes the following steps:

[0050] 1. Dissolve and disperse 3.5g of sodium alginate, 0.5g of thickener, 1.2g of calcium carbonate powder, and 0.2g of disinfectant in 100mL of water to prepare a first solution. The viscosity of the first solution is 25,000 cps (25°C). The mass concentration of sodium alginate is 3.3%; the mass concentration of calcium carbonate is 1.1%.

[0051] 2. Dissolve 0.5 g of gluconolactone in 100 mL of water to prepare the second solution.

[0052] 3. When in use, mix the first solution and the second solution and apply them to the surface of the hand, where the mass ratio of the first solution to the second solution is 1:1. After the gel is formed, the sodium alginate hydrogel disposable gloves are prepared in situ on the surface of the hand.

[0053] Example 4

[0054] The in-situ preparation of disposable gloves using sodium alginate hydrogel in this embodiment includes the following steps:

[0055] 1. Dissolve and disperse 2.5g of sodium alginate, 0.8g of thickener, 1g of calcium carbonate powder, and 0.2g of disinfectant in 100mL of water to prepare a first solution. The viscosity of the first solution is 26,000 cps (25°C). The mass concentration of sodium alginate is 2.5%; the mass concentration of calcium carbonate is 1%.

[0056] 2. Dissolve 0.3 g of gluconolactone in 100 mL of water to prepare the second solution.

[0057] 3. When in use, mix the first solution and the second solution and apply them to the surface of the hand, where the mass ratio of the first solution to the second solution is 1:1. After the gel is formed, the sodium alginate hydrogel disposable gloves are prepared in situ on the surface of the hand.

[0058] Comparative Example 1

[0059] The difference between this comparative example and Example 1 is that the concentration of calcium chloride in the second solution of this comparative example is 0.5%, resulting in insufficient gel strength and inability to form disposable gloves.

[0060] Comparative Example 2

[0061] The difference between this comparative example and Example 3 is that the concentration of gluconolactone in the second solution of this comparative example is too low, and the mass ratio of gluconolactone to calcium carbonate is 1:10, resulting in insufficient gel strength and inability to form disposable gloves.

[0062] Comparative Example 3

[0063] This comparative example differs from Example 3 in that the ratio of the first solution to the second solution is 3:1, meaning the proportion of the second solution is too low. The other ingredients and preparation steps are essentially the same as those in Example 3. The gel obtained in this comparative example is not strong enough to form a disposable glove.

[0064] Tests and Results

[0065] The preparation method described in the example was applied to a hand model, and after forming, the model was demoulded to obtain a sample glove. Water-impermeability and tensile properties were tested according to the method specified in GB24786-2009. The results are shown in Table 1.

[0066] Table 1 Test results

[0067] sample Impermeability Tensile strength (MPa) Example 1 qualified 18 Example 2 qualified 17 Example 3 qualified 22 Example 4 qualified 20 Commercially available polyethylene gloves qualified 17

[0068] Note: The commercially available gloves in the table are disposable polyethylene gloves produced by Haimen Yangzi Medical Instrument Co., Ltd.

[0069] According to the test results in Table 1, it can be seen that the in-situ sodium alginate hydrogel disposable gloves prepared by the present invention can achieve the same or better impermeability and tensile strength as existing commercially available disposable gloves, and can meet the needs of daily use.

[0070] The purpose of the present invention is to provide an in-situ sodium alginate hydrogel disposable glove, which is environmentally friendly, easy to use, and can fit the user's hand perfectly. The present invention adopts two methods: dissolving sodium alginate and a thickener in water to prepare a first solution; dissolving calcium chloride and a disinfectant in water to prepare a second solution. When in use, the first solution is evenly applied to the surface of the hand so that the surface of the hand is covered with a layer of sodium alginate solution, and then the second solution is sprayed on the surface of the hand in the form of a spray. After the two solutions come into contact, a hydrogel is quickly formed on the contact surface, wrapping the entire hand and making close contact with the skin of the hand; or, sodium alginate, a thickener, calcium carbonate powder, and a disinfectant are dissolved in water and dispersed evenly to obtain a first solution, and gluconolactone is dissolved in a small amount of water to obtain a second solution. Before use, the first solution and the second solution are evenly mixed and applied to the surface of the hand. After the solution is gelled, the gel layer will wrap the entire hand and make close contact with the skin of the hand; wherein gluconolactone will slowly hydrolyze and release H in the aqueous solution. + , so that calcium carbonate dissolves and releases Ca 2+ This gels the sodium alginate. The disposable gloves of the present invention can be formed in situ on the hand surface, perfectly fitting the hand shape and being easy to use, avoiding the problems of conventional disposable gloves being difficult to wear and not fitting properly. They are biodegradable sodium alginate hydrogels, making them environmentally friendly. Functional materials, such as disinfectants, can be added as needed to provide hand disinfection.

[0071] Although the present application is named as disposable gloves, it can also be used multiple times if it meets various usage requirements.

[0072] The above embodiments are only for illustrating the technical concept and features of the present invention. Their purpose is to enable people familiar with this technology to understand the contents of the present invention and implement them accordingly. They are not intended to limit the scope of protection of the present invention. Any equivalent changes or modifications made according to the spirit of the present invention should be included in the scope of protection of the present invention.

Claims

1. An in-situ preparation method for disposable gloves, for in-situ forming a sodium alginate hydrogel disposable glove on the surface of a human hand, characterized in that: The in-situ preparation method comprises the following steps: Dissolving sodium alginate, thickener, and calcium carbonate powder in water to prepare a first solution; dissolving gluconolactone in water to prepare a second solution; The first solution and the second solution are evenly mixed and then applied to the surface of the hand. After the gel is formed, a disposable glove of sodium alginate hydrogel is prepared in situ.

2. The in-situ preparation method according to claim 1, characterized in that The gluconolactone in the second solution is used to hydrolyze and release H in aqueous solution. + , so that calcium carbonate dissolves and releases Ca 2+ Thereby, the sodium alginate is gelled, and the gel layer wraps the entire hand and is in close contact with the hand skin, forming a sodium alginate hydrogel disposable glove in situ.

3. The in-situ preparation method according to claim 1, characterized in that The viscosity of the first solution at 25° C. is 10,000 to 40,000 cp.s.

4. The in-situ preparation method according to claim 1, characterized in that The mass ratio of the calcium carbonate to the sodium alginate is 0.3:1 to 0.8:

1.

5. The in-situ preparation method according to claim 1, characterized in that: The concentration of sodium alginate in the first solution is 1% to 5%.

6. The in-situ preparation method according to claim 1, characterized in that The mass concentration of the calcium carbonate in the first solution is 1% to 5%.

7. The in-situ preparation method according to claim 1, characterized in that The concentration of gluconolactone in the second solution is calculated based on a mass ratio of gluconolactone to calcium carbonate of 1:2 to 1:

6.

8. The in-situ preparation method according to claim 1, characterized in that: The thickener is a combination of one or more selected from carbomer, xanthan gum, sodium carboxymethyl cellulose, hydroxyethyl cellulose, polyethylene oxide, polyvinyl alcohol, and polyvinyl pyrrolidone.

9. The in-situ preparation method according to claim 1, characterized in that: The first solution and / or the second solution contains a disinfectant.

10. The in-situ preparation method according to claim 9, characterized in that: The disinfectant is a combination of one or more selected from medical alcohol, quaternary ammonium salt, benzalkonium chloride, triclosan, and polyhexamethylene biguanide.

11. The in-situ preparation method according to any one of claims 1 to 9, characterized in that: The steps further include cleaning and drying the hands before evenly applying the first solution to the surface of the hands.

12. An in-situ sodium alginate hydrogel disposable glove prepared by the in-situ preparation method according to any one of claims 1 to 11.