Reagent container and automatic analyzer

Abstract

The technical problem of the present invention is to appropriately reduce foam generated in a reagent in a reagent container. A reagent container according to an embodiment is provided in a rotating reagent reservoir of an automatic analyzer. The reagent container includes a stopper. The blocking portion partially blocks the rotating inner diameter side and outer diameter side inside the reagent container. The gap between the stopper and the side surface of the reagent container is configured so as to become larger from the upper portion toward the lower portion of the stopper.

Description

Technical Field

[0001] The embodiments disclosed in this specification and the accompanying drawings relate to a reagent container and an automatic analyzer. Background Art

[0002] Conventionally, automated analyzers dispense reagents and samples into reaction vessels, and then measure test items by optically measuring changes in color and turbidity caused by the reaction of the reagent-sample mixture. To dispense the reagent, the reagent reservoir containing the reagent container is rotated, moving the container to a suction position where a reagent dispensing probe aspirates the reagent.

[0003] Furthermore, conventional automated analyzers have included a liquid level sensing function to ensure that the reagent dispensing probe properly descends to the liquid level within the reagent container at the aspiration position. However, if foam forms in the reagent within the reagent container during rotation or stopping of the reagent reservoir, the liquid level sensing function may mistakenly detect the foam as the liquid level. In this case, the reagent dispensing probe cannot be properly lowered to the liquid level, making it difficult for the probe to properly aspirate the reagent.

[0004] Therefore, in order to reduce the foam generated in the reagent, a baffle is sometimes provided in the reagent container. The baffle reduces the foam generated in the reagent by suppressing the movement of the reagent in the reagent container.

[0005] Prior art literature

[0006] Patent Literature

[0007] Patent Document 1: Japanese Patent Application No. 2016-516990 Summary of the Invention

[0008] Technical problem to be solved by the invention

[0009] One of the problems to be solved by the embodiments disclosed in this specification and the accompanying drawings is to appropriately reduce the foam generated in the reagent in the reagent container.

[0010] Technical solutions to technical problems

[0011] A reagent container according to an embodiment is installed in a rotating reagent storage of an automated analyzer. The reagent container includes a blocking portion. The blocking portion partially blocks the inner and outer diameters of the reagent container during rotation. The gap between the blocking portion and the side of the reagent container is configured to increase from the upper portion of the blocking portion toward the lower portion. BRIEF DESCRIPTION OF THE DRAWINGS

[0012] Figure 1 This is a block diagram showing a configuration example of the automatic analyzer according to the first embodiment.

[0013] Figure 2Yes Figure 1 The diagram shows the configuration of the analysis mechanism.

[0014] Figure 3 It is a side view showing a configuration example of a reagent container according to the first embodiment.

[0015] Figure 4 It is a perspective view showing a configuration example of a reagent container according to the first embodiment.

[0016] Figure 5 This is a front view showing the blocking portion of the reagent container according to the first embodiment.

[0017] Figure 6 This is a diagram showing an example of the movement of the reagent in the reagent container according to the first embodiment.

[0018] Figure 7 It is a diagram showing an example of the movement of a reagent in a reagent container according to a comparative example.

[0019] Figure 8 This is a front view showing a blocking portion of a reagent container according to a first modification of the first embodiment.

[0020] Figure 9 This is a front view showing a blocking portion of a reagent container according to a second modified example of the first embodiment.

[0021] Figure 10 This is a front view showing a blocking portion of a reagent container according to a third modified example of the first embodiment.

[0022] Figure 11 This is a front view showing a blocking portion of a reagent container according to a fourth modified example of the first embodiment.

[0023] Figure 12 This is a front view showing a first blocking portion of a reagent container according to a second embodiment.

[0024] Figure 13 This is a diagram showing an example of the movement of a reagent in a reagent container according to the second embodiment. DETAILED DESCRIPTION

[0025] Hereinafter, embodiments of the automatic analyzer will be described in detail with reference to the accompanying drawings. In the following description, components having substantially the same function and configuration are denoted by the same reference numerals, and repeated description will be given only when necessary.

[0026] (First embodiment)

[0027] Figure 1 This is a block diagram showing a configuration example of the automatic analyzer 1 according to the first embodiment. Figure 1The illustrated automatic analyzer 1 includes an analyzing mechanism 2 , an analysis circuit 3 , a driving mechanism 4 , an input interface 5 , an output interface 6 , a communication interface 7 , a storage circuit 8 , and a control circuit 9 .

[0028] The analysis mechanism 2 adds the reagents used in each inspection item set for the sample to the sample such as the standard sample (i.e., calibrator) and the sample to be tested, thereby obtaining a mixture of the sample and the reagent (i.e., reaction solution). The analysis mechanism 2 measures the mixture of the sample and the reagent to generate standard data and tested data represented by, for example, absorbance or scattered light. The standard data represents measurement data of the absorbance, fluorescence intensity or scattered light amount of a standard sample whose concentration of the detection object is known, or measurement data of luminescence, phosphorescence or a combination thereof. In addition, the tested data represents measurement data of the absorbance, fluorescence intensity or scattered light amount of the tested sample. In addition, in the following description, when the standard sample and the tested sample are not distinguished, they are sometimes simply referred to as "samples".

[0029] The analysis circuit 3 is a processor that analyzes the standard data and test data generated by the analysis unit 2 to generate calibration data, analytical data, and the like. Calibration data, for example, represents the relationship between the standard data and a pre-set standard calibration curve for a standard sample. For example, a standard calibration curve is a calibration curve calculated by a reagent manufacturer using a standard sample to provide high measurement accuracy. Analytical data, for example, is obtained by analyzing the test data based on the calibration data and is expressed as concentration values and enzyme activity values.

[0030] The analysis circuit 3 executes the operating program stored in the storage circuit 8 and implements the functions corresponding to the operating program, thereby generating calibration data and analytical data. For example, the analysis circuit 3 calculates calibration data based on standard data obtained for a standard sample with a known absorbance or scattered light amount and a concentration of zero, and multiple standard samples with known absorbance or scattered light amounts and known concentrations, a pre-set standard calibration curve for these standard samples, and pre-set photometry timing. Furthermore, the analysis circuit 3 generates analytical data based on the test data, calibration data for the inspection items corresponding to the test data, and pre-set photometry timing. The analysis circuit 3 outputs the generated calibration data and analytical data to the control circuit 9.

[0031] The driving mechanism 4 drives the analyzing mechanism 2 according to the control of the control circuit 9. The driving mechanism 4 is realized by, for example, gears, a stepping motor, a belt, a lead screw, and the like.

[0032] The input interface 5 receives settings of analysis parameters and the like for various test items of the sample to be measured, for example, from an operator or via the hospital network NW. The input interface 5 is implemented by, for example, a mouse, a keyboard, and a touchpad for inputting instructions by touching the operation surface. The input interface 5 is connected to the control circuit 9, converts the operation instructions input by the user into electrical signals, and outputs the electrical signals to the control circuit 9. In addition, in this specification, the input interface 5 is not limited to an interface having physical operating components such as a mouse and a keyboard. For example, a processing circuit that receives an electrical signal corresponding to an operation instruction input from an external input device that is separately provided relative to the automatic analyzer 1 and outputs the electrical signal to the control circuit 9 is also included in the example of the input interface 5.

[0033] The output interface 6 is connected to the control circuit 9 and outputs signals supplied from the control circuit 9. The output interface 6 is implemented, for example, by a display circuit and a printed circuit. Examples of display circuits include CRT displays, liquid crystal displays, organic EL displays, LED displays, and plasma displays. Furthermore, the display circuit also includes a processing circuit that converts data representing a display object into a video signal and outputs the video signal externally. Examples of printed circuits include printers. Furthermore, the printed circuit also includes an output circuit that outputs data representing a print object externally.

[0034] The communication interface 7 is connected to, for example, an intra-hospital network NW. The communication interface 7 performs data communication with an HIS (Hospital Information System) via the intra-hospital network NW. Alternatively, the communication interface 7 may perform data communication with an HIS via a laboratory information system (LIS) connected to the intra-hospital network NW.

[0035] The storage circuit 8 is a non-temporary storage device that stores various types of information, such as an HDD (Hard Disk Drive), an optical disk, an SSD (Solid State Drive), and an integrated circuit storage device. The storage circuit 8 stores, for example, a control program for controlling the automatic analyzer 1 and various data used to execute the control program. In addition to HDDs and SSDs, the storage circuit 8 can also be a drive device that reads and writes various types of information to and from removable storage media such as CDs (Compact Discs), DVDs (Digital Versatile Discs), and flash memory, or semiconductor memory devices such as RAM (Random Access Memory). Furthermore, the storage circuit 8 does not necessarily need to be implemented by a single storage device. For example, the storage circuit 8 can also be implemented by multiple storage devices.

[0036] More specifically, the storage circuit 8 stores an action program executed by the analysis circuit 3 and an action program executed by the control circuit 9. The storage circuit 8 stores calibration curve information related to the reagents held in the analysis mechanism 2. The calibration curve information includes data related to a standard calibration curve pre-set for the reagents for each inspection item. The calibration curve information is provided by the reagent manufacturer via the communication interface 7, for example, in units of reagent batches. Alternatively, the calibration curve information may be provided by the reagent manufacturer together with the reagents and input by the user through the input interface 5.

[0037] The control circuit 9 is a processor that functions as the core of the automatic analyzer 1. The control circuit 9 implements the functions corresponding to the operating program by executing the operating program stored in the storage circuit 8. The control circuit 9 may also include a storage area for storing at least a portion of the data stored in the storage circuit 8.

[0038] Figure 2 Yes Figure 1 The schematic diagram of an example of the structure of the analysis mechanism 2 shown. Figure 2 The illustrated analysis mechanism 2 includes a reaction disk 201 , a constant temperature section 202 , a sample disk 203 , a first reagent reservoir 204 , and a second reagent reservoir 205 .

[0039] The reaction disk 201 transports the reaction containers 2011 along a predetermined path. Specifically, the reaction disk 201 holds a plurality of reaction containers 2011 arranged in a ring. The reaction disk 201 is rotated and stopped alternately and repeatedly at predetermined time intervals by the driving mechanism 4 .

[0040] For example, the reaction vessel 2011 is fed to the Figure 2 The reaction vessels 2011 are rotated and moved in the direction of arrow R1, stopping at a different stop position than before the movement. For example, the reaction vessel 2011 is rotated and moved in the direction R1 for each cycle time by the rotation of the reaction disk 201. The reaction vessels 2011 stop at a position adjacent to the reaction vessel 2011 in the direction R1, relative to the reaction vessel 2011 located at a 90° angle in the direction R1 from its position before the movement. Subsequently, the reaction vessels 2011 stop at the same stop position for each round time, which is longer than one cycle time.

[0041] The stop positions of the reaction container 2011 include a sample discharge position, a first reagent discharge position, a second reagent discharge position, a first stirring position, a second stirring position, and a washing position, which will be described later.

[0042] Reaction vessel 2011 is formed, for example, of glass. Reaction vessel 2011 has a quadrangular prism shape and an opening at its top. Light emitted from a light source provided in photometric unit 214 enters the outer surface of a first side wall, one of the first to fourth side walls forming the quadrangular prism. Light incident from the outer surface of the first side wall is emitted from the outer surface of a second side wall, one of the first to fourth side walls, that is opposite the first side wall.

[0043] The constant temperature unit 202 stores a heat medium set to a predetermined temperature. The constant temperature unit 202 immerses the reaction container 2011 in the stored heat medium to increase the temperature of the mixed solution contained in the reaction container 2011 .

[0044] The sample tray 203 holds a plurality of sample containers containing samples and is rotated and stopped by the driving mechanism 4 according to each cycle time.

[0045] The first reagent storage 204 keeps cold a plurality of reagent containers 2042 containing first reagents that react with specified components contained in standard samples and test samples. The first reagent can be, for example, a buffer solution containing bovine serum albumin (BSA). A reagent label is affixed to the reagent container 2042. An optical mark indicating reagent information is printed on the reagent label. For example, any pixel code such as a one-dimensional pixel code and a two-dimensional pixel code is used in the optical mark. The reagent information is information related to the reagent contained in the reagent container 2042, including, for example, the reagent name, reagent manufacturer code, reagent item code, bottle type, bottle size, capacity, manufacturing batch number, and validity period.

[0046] The first reagent storage 204 also keeps a plurality of standard sample containers containing standard samples cool. Standard sample containers can also contain standard samples of the same component with different concentrations. Furthermore, the standard sample containers can also be held on the sample tray 203.

[0047] In the first reagent storehouse 204, a reagent rack 2041 is provided in a rotatable manner. The reagent rack 2041 arranges a plurality of reagent containers 2042 and a plurality of standard sample containers into an annular shape and holds them. The reagent rack 2041 rotates and stops according to each cycle time by the driving mechanism 4. In addition, a reader (not shown) is provided in the first reagent storehouse 204 to read reagent information from the reagent label attached to the reagent container 2042. The reagent information read is stored by the storage circuit 8.

[0048] A first reagent aspiration position is set at a predetermined position on the first reagent storage 204. The first reagent aspiration position is provided, for example, at a position where the rotation trajectory of the first reagent dispensing probe 209 intersects with the movement trajectory of the openings of the reagent containers 2042 and the standard sample containers arranged in an annular pattern on the reagent tray 2041.

[0049] The second reagent reservoir 205, for example, keeps cold a plurality of reagent containers 2052 containing a second reagent, which is paired with the first reagent of a dual-reagent system. The second reagent can be, for example, a solution containing a predetermined antigen or antibody contained in a sample and an insoluble carrier, such as carrier particles, immobilized with the antigen or antibody that binds or separates through a specific antigen-antibody reaction. The substance that binds or separates through a specific reaction can be an enzyme, a matrix, an aptamer, or a receptor. A reagent rack 2051 is rotatably mounted within the second reagent reservoir 205.

[0050] The reagent rack 2051 arranges and maintains a plurality of reagent containers 2052 in an annular shape. In addition, in the second reagent storehouse 205, the standard sample container for accommodating the standard sample can also be kept cold. The reagent rack 2051 rotates and stops according to each cycle time by the driving mechanism 4. In addition, a reader (not shown) is provided in the second reagent storehouse 205 to read the reagent information from the reagent label attached to the reagent container 2052. The reagent information read is stored by the storage circuit 8.

[0051] A second reagent aspiration position is set at a predetermined position on the second reagent storage 205. The second reagent aspiration position is provided at a position where the rotation trajectory of the second reagent dispensing probe 211 intersects the movement trajectory of the openings of the reagent containers 2052 arranged in an annular pattern on the reagent tray 2051.

[0052] in addition, Figure 2 The illustrated analysis mechanism 2 includes a sample dispensing arm 206, a sample dispensing probe 207, a first reagent dispensing arm 208, a first reagent dispensing probe 209, a second reagent dispensing arm 210, a second reagent dispensing probe 211, a first stirring unit 212, a second stirring unit 213, a photometry unit 214, and a cleaning unit 215. The sample dispensing probe 207 is an example of a first dispensing probe. The first reagent dispensing probe 209 and the second reagent dispensing probe 211 are examples of second dispensing probes.

[0053] The sample dispensing arm 206 is provided between the reaction disk 201 and the sample disk 203. The sample dispensing arm 206 is movable vertically and rotatable horizontally by the drive mechanism 4. The sample dispensing arm 206 holds a sample dispensing probe 207 at one end.

[0054] The sample dispensing probe 207 rotates along an arc-shaped trajectory as the sample dispensing arm 206 rotates. The opening of the sample container held by the sample disk 203 is located on this trajectory. Furthermore, a sample ejection position is provided on the rotation trajectory of the sample dispensing probe 207 for ejecting the sample drawn by the sample dispensing probe 207 into the reaction container 2011. The sample ejection position corresponds to, for example, the intersection of the rotation trajectory of the sample dispensing probe 207 and the movement trajectory of the reaction container 2011 held on the reaction disk 201.

[0055] The sample dispensing probe 207 is driven by the drive mechanism 4 to move directly above the opening of the sample container held by the sample disk 203, or to move in the vertical direction at the sample ejection position. Furthermore, the sample dispensing probe 207 dispenses the sample in accordance with the operation of the dispensing pump connected to the sample dispensing probe 207. Specifically, the sample dispensing probe 207 draws the sample from the sample container directly below it through the suction operation of the dispensing pump, which is controlled by the control circuit 9. Furthermore, the sample dispensing probe 207 ejects the drawn sample into the reaction container 2011, which is directly below the sample ejection position, through the ejection operation of the dispensing pump, which is controlled by the control circuit 9.

[0056] The first reagent dispensing arm 208 is provided near the outer periphery of the first reagent reservoir 204. The first reagent dispensing arm 208 is provided to be movable vertically and horizontally by the drive mechanism 4. The first reagent dispensing arm 208 holds a first reagent dispensing probe 209 at one end.

[0057] The first reagent dispensing probe 209 rotates along an arc-shaped rotation trajectory as the first reagent dispensing arm 208 rotates. A first reagent suction position is provided on this rotation trajectory. Furthermore, a first reagent discharge position is provided on the rotation trajectory of the first reagent dispensing probe 209 for discharging the first reagent or standard sample sucked by the first reagent dispensing probe 209 into the reaction container 2011. The first reagent discharge position corresponds to the intersection of the rotation trajectory of the first reagent dispensing probe 209 and the movement trajectory of the reaction container 2011 held by the reaction disk 201.

[0058] The first reagent dispensing probe 209 is driven by the drive mechanism 4 and moves vertically at a first reagent suction position or a first reagent discharge position on a rotational trajectory. The first reagent dispensing probe 209 dispenses the first reagent or standard sample in accordance with the operation of a first reagent pump connected to the first reagent dispensing probe 209. Specifically, the first reagent dispensing probe 209 draws the first reagent or standard sample from the reagent container 2042 located directly below the first reagent suction position by the suction operation of the first reagent pump in accordance with the control of the control circuit 9. Furthermore, the first reagent dispensing probe 209 discharges the drawn first reagent or standard sample into the reaction container 2011 located directly below the first reagent discharge position by the discharge operation of the first reagent pump in accordance with the control of the control circuit 9.

[0059] The second reagent dispensing arm 210 is provided near the outer periphery of the first reagent reservoir 204. The second reagent dispensing arm 210 is provided to be movable vertically and horizontally by the drive mechanism 4. The second reagent dispensing arm 210 holds a second reagent dispensing probe 211 at one end.

[0060] The second reagent dispensing probe 211 rotates along an arc-shaped rotation trajectory as the second reagent dispensing arm 210 rotates. A second reagent suction position is provided on this rotation trajectory. Furthermore, a second reagent discharge position is provided on the rotation trajectory of the second reagent dispensing probe 211 for dispensing the second reagent sucked by the second reagent dispensing probe 211 into the reaction container 2011. The second reagent discharge position corresponds to the intersection of the rotation trajectory of the second reagent dispensing probe 211 and the movement trajectory of the reaction container 2011 held by the reaction disk 201.

[0061] The second reagent dispensing probe 211 is driven by the drive mechanism 4 and moves vertically between the second reagent suction position and the second reagent discharge position on the rotational trajectory. The second reagent dispensing probe 211 dispenses the second reagent in accordance with the operation of the second reagent pump connected to the second reagent dispensing probe 211. Specifically, the second reagent dispensing probe 211 draws the second reagent from the reagent container 2052 located directly below the second reagent suction position through the suction operation of the second reagent pump in accordance with the control of the control circuit 9. Furthermore, the second reagent dispensing probe 211 discharges the drawn second reagent into the reaction container 2011 located directly below the second reagent discharge position through the discharge operation of the second reagent pump in accordance with the control of the control circuit 9.

[0062] The first stirring unit 212 is disposed near the outer periphery of the reaction disk 201. The first stirring unit 212 includes a first stirring arm 2121 and a first stirring member disposed at the front end of the first stirring arm 2121. The first stirring unit 212 utilizes the first stirring member to stir the standard sample and the first reagent contained in the reaction container 2011 located at the first stirring position on the reaction disk 201. Furthermore, the first stirring unit 212 utilizes the first stirring member to stir the sample and the first reagent contained in the reaction container 2011 located at the first stirring position on the reaction disk 201.

[0063] The second stirring unit 213 is disposed near the outer periphery of the reaction disk 201. The second stirring unit 213 includes a second stirring arm 2131 and a second stirring member disposed at the front end of the second stirring arm 2131. The second stirring unit 213 utilizes the second stirring member to stir the standard sample, the first reagent, and the second reagent contained in the reaction container 2011 located at the second stirring position on the reaction disk 201. Furthermore, the second stirring unit 213 utilizes the second stirring member to stir the sample, the first reagent, and the second reagent contained in the reaction container 2011 located at the second stirring position.

[0064] The photometric unit 214 optically measures the mixture of the sample, first reagent, and second reagent dispensed into the reaction vessel 2011 at the photometric position. More specifically, the photometric unit 214 measures the photometry of the mixture held in the reaction vessel 2011 as it passes the photometric position due to rotation of the reaction disk 201 by the drive mechanism 4. The photometric unit 214 includes a light source and a photodetector. Under control of the control circuit 9, the photometric unit 214 irradiates light from the light source. The irradiated light enters the first sidewall of the reaction vessel 2011 and exits the second sidewall opposite the first sidewall. The photometric unit 214 detects the light exiting the reaction vessel 2011 using the photodetector.

[0065] For example, the photodetector is positioned on the optical axis of light irradiated from the light source toward the reaction vessel 2011. Furthermore, the photodetector detects light that has passed through the mixture of the standard sample, the first reagent, and the second reagent within the reaction vessel 2011, and generates standard data represented by absorbance, etc., based on the intensity of the detected light. Furthermore, the photodetector detects light that has passed through the mixture of the test sample, the first reagent, and the second reagent within the reaction vessel 2011, and generates test data represented by absorbance, etc., based on the intensity of the detected light. The photometric unit 214 outputs the generated standard data and test data to the analysis circuit 3.

[0066] The cleaning unit 215 cleans the reaction container 2011 located at the cleaning position and having been subjected to measurement. More specifically, the cleaning unit 215 cleans the interior of the reaction container 2011 after the measurement of the mixed solution by the photometric unit 214 is completed.

[0067] Figure 1 The control circuit 9 shown controls the overall operation of the automatic analyzer 1 based on an electrical signal of an input operation input from the input interface 5. For example, the control circuit 9 includes a system control function 91, a calibration control function 92, and a measurement control function 93.

[0068] Here, for example, as Figure 1 The processing functions executed by the system control function 91, the calibration control function 92, and the measurement control function 93 of the components of the control circuit 9 shown are recorded in the storage circuit 8 in the form of programs that can be executed by a computer. The control circuit 9 is, for example, a processor. The processor constituting the control circuit 9 reads out each program from the storage circuit 8 and executes it, thereby realizing the function corresponding to each program read out. In other words, the control circuit 9 that has read out the status of each program has the following functions: Figure 1 The various functions represented within the control circuit 9.

[0069] In addition, Figure 1 91, calibration control function 92, and measurement control function 93 are implemented by a single control circuit 9, but the embodiment is not limited to this. For example, the control circuit 9 may be composed of a combination of multiple independent processors, with each processor executing a program to implement each processing function. Furthermore, the processing functions of the control circuit 9 may be appropriately distributed or integrated into a single or multiple control circuits.

[0070] The system control function 91 is a function for comprehensively controlling each unit in the automatic analyzer 1 based on input information input from the input interface 5 .

[0071] Calibration control function 92 controls analysis mechanism 2 and drive mechanism 4 to generate standard data. Specifically, control circuit 9 executes calibration control function 92 at predetermined timings. Examples of predetermined timings include initial setup, device startup, maintenance, and when a user inputs a command to start calibration.

[0072] When the calibration control function 92 is executed, the control circuit 9 controls the analysis mechanism 2 and the drive mechanism 4. By controlling the analysis mechanism 2 and the drive mechanism 4, standard data is generated in the analysis mechanism 2. Specifically, for example, the first reagent dispensing probe 209 of the analysis mechanism 2, driven by the drive mechanism 4, aspirates a standard sample from the first reagent reservoir 204 and ejects the aspirated standard sample into the reaction vessel 2011. The first reagent dispensing probe 209 aspirates a first reagent from the first reagent reservoir 204 and ejects the aspirated first reagent into the reaction vessel 2011 from which the standard sample was ejected. The first stirring unit 212 stirs the solution containing the first reagent added to the standard sample.

[0073] The second reagent dispensing probe 211 draws the second reagent from the second reagent reservoir 205 and ejects the drawn second reagent into the mixed solution of the standard sample and the first reagent. The second stirring unit 213 stirs the solution to which the second reagent is added. The photometric unit 214 generates standard data by optically measuring the mixed solution formed by stirring the standard sample, the first reagent, and the second reagent. The photometric unit 214 outputs the generated standard data to the analysis circuit 3. The photometric unit 214 repeatedly measures the mixed solution a predetermined number of times in a predetermined cycle and outputs the generated standard data to the analysis circuit 3. The analysis mechanism 2 repeatedly performs the above-mentioned operation on a plurality of predetermined concentrations of standard samples and outputs the generated standard data to the analysis circuit 3.

[0074] The measurement control function 93 controls the analysis mechanism 2 and the drive mechanism 4 to generate test data. Specifically, the control circuit 9 executes the measurement control function 93 in accordance with predetermined instructions. Predetermined instructions include, for example, user-input instructions to start a measurement operation and instructions indicating the arrival of a preset time.

[0075] When the measurement control function 93 is executed, the control circuit 9 controls the analysis mechanism 2 and the drive mechanism 4. By controlling the analysis mechanism 2 and the drive mechanism 4, test data is generated in the analysis mechanism 2. Specifically, driven by the drive mechanism 4, the sample dispensing probe 207 of the analysis mechanism 2 aspirates the test sample from the sample disk 203 and discharges the aspirated test sample into the reaction container 2011. The first reagent dispensing probe 209 aspirates the first reagent from the first reagent reservoir 204 and discharges the aspirated first reagent into the reaction container 2011 from which the test sample has been discharged. When the first reagent dispensing probe 209 aspirates the first reagent, the control circuit 9 senses the liquid level of the first reagent in the reagent container 2042 based on the contact state of the first reagent dispensing probe 209 with the reagent in the reagent container 2042. For example, the control circuit 9 senses the liquid level of the first reagent based on changes in electrical characteristics (e.g., capacitance or resistance) when the lower end of the first reagent dispensing probe 209 contacts the first reagent. Then, the control circuit 9 causes the driving mechanism 4 to lower the first reagent dispensing probe 209 until the first reagent liquid level is sensed, and to aspirate the first reagent by the first reagent dispensing probe 209. The first stirring unit 212 stirs the solution containing the first reagent added to the test sample.

[0076] The second reagent dispensing probe 211 draws the second reagent from the second reagent reservoir 205 and dispenses the drawn second reagent into the mixed solution of the test sample and the first reagent. Similar to the case where the first reagent dispensing probe 209 draws the first reagent, when the second reagent dispensing probe 211 draws the second reagent, the control circuit 9 causes the drive mechanism 4 to lower the second reagent dispensing probe 211 until the second reagent liquid level is sensed, and then the second reagent dispensing probe 211 draws the second reagent. The second stirring unit 213 stirs the solution to which the second reagent has been added. The photometric unit 214 optically measures the mixed solution formed by the stirring of the test sample, the first reagent, and the second reagent to generate test data. The photometric unit 214 outputs the generated test data to the analysis circuit 3. The photometric unit 214 repeatedly measures the mixed solution a predetermined number of times at a predetermined cycle and outputs the generated test data to the analysis circuit 3.

[0077] The analysis circuit 3 is a processor that analyzes the standard data and test data generated by the analysis unit 2 to generate calibration data, analytical data, and the like. Calibration data, for example, represents the relationship between the standard data and a pre-set standard calibration curve for a standard sample. For example, a standard calibration curve is a calibration curve calculated by a reagent manufacturer using a standard sample to provide high measurement accuracy. Analytical data, for example, is obtained by analyzing the test data based on the calibration data and is expressed as concentration values and enzyme activity values.

[0078] The analysis circuit 3 executes the operating program stored in the storage circuit 8 and implements the functions corresponding to the operating program, thereby generating calibration data and analytical data. For example, the analysis circuit 3 calculates calibration data based on standard data obtained for a standard sample with a known absorbance or scattered light amount and a concentration of zero, and multiple standard samples with known absorbance or scattered light amounts and known concentrations, a pre-set standard calibration curve for these standard samples, and pre-set photometry timing. Furthermore, the analysis circuit 3 generates analytical data based on the test data, calibration data for the inspection items corresponding to the test data, and pre-set photometry timing. The analysis circuit 3 outputs the generated calibration data and analytical data to the control circuit 9.

[0079] Next, the reagent container 2042 of the first embodiment will be described in detail. The following describes the configuration of the reagent container 2042 located in the first reagent storage 204 , but the configuration of the reagent container 2052 located in the second reagent storage 205 may be the same as that of the reagent container 2042 . Figure 3 This is a side view showing a configuration example of the reagent container 2042 according to the first embodiment. Figure 4 It is a perspective view showing a configuration example of the reagent container 2042 according to the first embodiment. Figure 51 is a front view showing the blocking portions 13A, 13B, 13C, and 13D of the reagent container 2042 according to the first embodiment. Figures 3 to 5 In the diagram, the D1 direction is defined as the inner side of the rotation radius of the first reagent reservoir 204, i.e., the inner diameter side. Furthermore, the D2 direction is defined as the outer side of the rotation radius of the first reagent reservoir 204, i.e., the outer diameter side. Furthermore, the D3 direction is defined as upward, and the D4 direction is defined as downward.

[0080] like Figure 3 and Figure 4 As shown, the reagent container 2042 includes a plate-shaped cover 11 formed with a first reagent removal port 14 and a main body 12 with the cover 11 fixed to the top. The reagent container 2042 is mounted in the rotating first reagent reservoir 204 of the automatic analyzer 1. The reagent container 2042 includes four blocking portions 13A, 13B, 13C, and 13D, consisting of a first blocking portion 13A, a second blocking portion 13B, a third blocking portion 13C, and a fourth blocking portion 13D. The number of blocking portions 13A, 13B, 13C, and 13D is not limited to four. For example, the number of blocking portions can be one or more and three or less, or five or more.

[0081] The blocking portions 13A, 13B, 13C, and 13D partially block the inner and outer diameter sides of the first reagent reservoir 204 during rotation within the reagent container 2042. The first blocking portion 13A is positioned closest to the inner diameter side D1 of the four blocking portions 13A, 13B, 13C, and 13D. The first blocking portion 13A is positioned closer to the inner diameter side D1 than the removal port 14. The first blocking portion 13A partially blocks the inner diameter side D1 and the outer diameter side D2 of the first blocking portion 13A within the reagent container 2042. The second blocking portion 13B is positioned closer to the outer diameter side D2 than the removal port 14. The second blocking portion 13B partially blocks the inner diameter side D1 and the outer diameter side D2 of the second blocking portion 13B within the reagent container 2042. The third blocking portion 13C is disposed on the outer diameter side D2 of the second blocking portion 13B. The third blocking portion 13C partially blocks an area within the reagent container 2042 that is closer to the inner diameter side D1 than the third blocking portion 13C and an area closer to the outer diameter side D2 than the third blocking portion 13C. The fourth blocking portion 13D is disposed on the outer diameter side D2 of the third blocking portion 13C. The fourth blocking portion 13D partially blocks an area within the reagent container 2042 that is closer to the inner diameter side D1 than the fourth blocking portion 13D and an area closer to the outer diameter side D2 than the fourth blocking portion 13D.

[0082] Here, the blocking portions 13A, 13B, 13C, and 13D are provided to reduce foam generated in the first reagent R. However, if the gaps G1 and G2 between the blocking portions 13A, 13B, 13C, and 13D and the reagent container side surfaces 1221 and 1222 are not appropriately maintained, the first reagent R may foam due to the structure of the blocking portions 13A, 13B, 13C, and 13D.

[0083] Therefore, in order to suppress the generation of bubbles in the first reagent R due to the structure of the blocking portions 13A, 13B, 13C, and 13D, in the first embodiment, the gaps G1 and G2 between the blocking portions 13A, 13B, 13C, and 13D and the reagent container side surfaces 1221 and 1222 are appropriately maintained. Specifically, Figure 5 As shown, the gaps G1 and G2 between the blocking portions 13A, 13B, 13C, and 13D and the reagent container side surfaces 1221 and 1222 are configured to increase from the top toward the bottom of the blocking portions 13A, 13B, 13C, and 13D. More specifically, the gap G1 between one end 131 of the blocking portions 13A, 13B, 13C, and 13D in the rotational direction R1 of the first reagent reservoir 204 and one side surface 1221 (i.e., the first side surface) of the reagent container 2042 facing the end 131 in the rotational direction R1 of the first reagent reservoir 204 is configured to increase from the top toward the bottom of the blocking portions 13A, 13B, 13C, and 13D. Furthermore, a gap G2 between the other end 132 of the blocking portions 13A, 13B, 13C, and 13D in the rotational direction R1 of the first reagent reservoir 204 and the other side surface 1222 (i.e., the second side surface) of the reagent container 2042 in the rotational direction R1 of the first reagent reservoir 204 facing the end 132 is also configured to increase in size from the top toward the bottom of the blocking portions 13A, 13B, 13C, and 13D. At the same height, the two gaps G1 and G2 may be the same size.

[0084] like Figure 3 As shown, stoppers 13A, 13B, 13C, and 13D are provided on the inner upper surface 111 of the reagent container 2042 (i.e., the lower surface of the lid 11) so as to extend downwardly D4 in a direction toward the bottom surface 121 of the reagent container 2042. Stoppers 13A, 13B, 13C, and 13D are integrally formed with the lid 11 using, for example, a mold.

[0085] The above-mentioned removal port 14 is provided at a position on the inner diameter side D1 of the inner upper surface 111 of the reagent container 2042 so as to penetrate the inner upper surface 111. Figure 3 and Figure 4As shown, the bottom surface 121 of the reagent container 2042 is inclined so as to move away from the inner upper surface 111 as it approaches the removal port 14 in the direction of the rotation radius of the first reagent reservoir 204. The bottom surface 121 of the reagent container 2042 is inclined so as to move away from the inner upper surface 111 as it approaches the removal port 14, thereby reducing the dead volume of the reagent container 2042 where the first reagent is not sucked out and accumulates. Figure 4 As shown, by providing a recessed portion 121 a on the bottom surface 121 that faces the removal port 14 , the dead volume can be further reduced.

[0086] As described above, the four blocking portions 13A, 13B, 13C, and 13D are spaced apart in the direction of the rotation radius of the first reagent reservoir 204. Of the four blocking portions 13A, 13B, 13C, and 13D, the first blocking portion 13A and the second blocking portion 13B, which are closer to the removal port 14, extend to a position D4 below (i.e., toward the bottom surface 121) than the third blocking portion 13C and the fourth blocking portion 13D, which are farther from the removal port 14. Furthermore, the third blocking portion 13C, which is closer to the removal port 14 than the fourth blocking portion 13D, extends to a position D4 below the fourth blocking portion 13D. The lower ends of the blocking portions 13A, 13B, 13C, and 13D may be in contact with the bottom surface 121 or may be spaced apart from the bottom surface 121 upward by D3.

[0087] like Figure 5 As shown in FIG. 1 , the width W of the blocking portions 13A, 13B, 13C, and 13D in the rotation direction R1 of the first reagent reservoir 204 decreases from the upper portion to the lower portion of the blocking portions 13A, 13B, 13C, and 13D. Figure 5 In the illustrated example, the width W of the blocking portions 13A, 13B, 13C, and 13D decreases continuously from the top to the bottom of the blocking portions 13A, 13B, 13C, and 13D. More specifically, the ends 131 and 132 of the blocking portions 13A, 13B, 13C, and 13D in the rotational direction R1 of the first reagent reservoir 204 have a straight line shape that is inclined relative to the reagent container side surfaces 1221 and 1222. In other words, when viewed in the direction of the rotational radius of the first reagent reservoir 204, the blocking portions 13A, 13B, 13C, and 13D have a trapezoidal shape (i.e., a wedge shape).

[0088] The angle formed by the ends 131 and 132 of the blocking portions 13A, 13B, 13C, and 13D relative to the reagent container side surfaces 1221 and 1222 in the rotation direction R1 of the first reagent storage 204 (hereinafter also referred to as the first inclination angle) may be 1.5° or greater. The first inclination angle is more preferably 2° or greater, and even more preferably 3° or greater.

[0089] The first inclination angle is greater than the second inclination angle formed by the end portions 133 of the blocking portions 13A, 13B, 13C, and 13D in the rotation radius direction relative to the side surfaces (i.e., the side surfaces of the second reagent container) 1223 and 1224 oriented to intersect the rotation radius direction of the first reagent reservoir 204. The side surfaces 1223 and 1224 oriented to intersect the rotation radius direction connect the side surfaces 1221 and 1222 oriented to intersect the rotation direction R1. Figure 3 In the example shown, the second inclination angle is almost 0°. The first inclination angle can also be referred to as the gradient of the barrier portions 13A, 13B, 13C, and 13D in the width direction. The second inclination angle can also be referred to as the gradient of the barrier portions 13A, 13B, 13C, and 13D in the thickness direction.

[0090] like Figure 3 As shown, the reagent container 2042 further includes a reinforcing portion 15 connected to the blocking portions 13A, 13B, 13C, and 13D and reinforcing the blocking portions 13A, 13B, 13C, and 13D. Figure 3 In the example shown, the reinforcement 15 projects from the center of the stoppers 13A, 13B, 13C, and 13D in the rotational direction R1 toward the outer diameter D2. Alternatively, the reinforcement 15 may project from the center of the stoppers 13A, 13B, 13C, and 13D in the rotational direction R1 toward the inner diameter D1.

[0091] The cover portion 11 and the main body portion 12 provided with the stopper portions 13A, 13B, 13C, and 13D can be formed by, for example, resin molding using a mold.

[0092] Next, an example of the movement of the reagent in the reagent container 2042 configured as described above will be described. Figure 6 This is a diagram showing an example of the movement of the reagent in the reagent container 2042 according to the first embodiment.

[0093] When the reagent container 2042 disposed in the first reagent storage 204 is moved to the first suction position, the driving mechanism 4 rotates the first reagent storage 204 in the rotation direction R1. When the first reagent storage 204 rotates, the centrifugal force generated by the rotation of the first reagent storage 204 acts on the first reagent R in the reagent container 2042. By the centrifugal force, as shown in FIG. Figure 6 As shown, the first reagent R in the reagent container 2042 moves toward the outer diameter side D2 of the reagent container 2042 (step S1).

[0094] When the first reagent reservoir 204 reaches the first suction position, the drive mechanism 4 stops the rotation of the first reagent reservoir 204. When the rotation of the first reagent reservoir 204 stops, the centrifugal force generated by the rotation of the first reagent reservoir 204 no longer acts on the first reagent R in the reagent container 2042. Due to the lack of centrifugal force, the first reagent R that has moved to the outer diameter side D2 of the reagent container 2042 tends to return to the inner diameter side D1.

[0095] At this time, the gaps G1 and G2 between the blocking portions 13A, 13B, 13C, and 13D and the side surfaces 1221 and 1222 of the reagent containers increase from the upper portion to the lower portion of the blocking portions 13A, 13B, 13C, and 13D. Figure 6 As shown by arrow A1 , the first reagent R located on the lower side D4 where the gaps G1 and G2 are wide returns to the inner diameter side D1 earlier than the first reagent R located on the upper side D3 where the gaps G1 and G2 are narrow (step S2 ).

[0096] Since the first reagent R on the lower D4 side returns to the inner diameter side D1 first, the first reagent can be smoothly returned to the inner diameter side D1. This can prevent the first reagent R on the upper D3 side from being drawn in (step S3). Figure 6 Arrow A2 superimposed with an "X" symbol in the figure indicates that the first reagent R indicated by arrow A2 is prevented from being drawn in. Furthermore, the blocking portions 13A, 13B, 13C, and 13D also prevent the first reagent R from being drawn in when the first reagent reservoir 204 rotates from a stopped state. This prevents the first reagent R from being drawn in, thereby reducing the amount of foam, or bubbles, generated in the first reagent R.

[0097] Figure 7 2 is a diagram showing an example of the movement of the reagent in the reagent container 2042 of the comparative example. On the other hand, assuming that the gaps G1 and G2 between the blocking portions 13A, 13B, 13C, and 13D and the reagent container side surfaces 1221 and 1222 decrease from the upper portion to the lower portion of the blocking portions 13A, 13B, 13C, and 13D, as shown in FIG. Figure 7 As shown by the arrow A3, the first reagent R on the upper D3 side where the gaps G1 and G2 are wide first returns to the inner diameter side D1 (step S2). Figure 7 As shown by arrow A4, the first reagent R on the upper side D3 is drawn in (step S3). As the first reagent R is drawn in, foam is generated in the first reagent R.

[0098] As described above, in the first embodiment, the gaps G1 and G2 between the stoppers 13A, 13B, 13C, and 13D and the reagent container side surfaces 1221 and 1222 are configured to increase from the upper portion toward the lower portion of the stoppers 13A, 13B, 13C, and 13D.

[0099] Thus, when the first reagent R is moved as the first reagent reservoir 204 rotates or stops, the first reagent R on the lower D4 side can be moved first, thereby preventing the first reagent R from being drawn in. Since the first reagent R can be prevented from being drawn in, the generation of foam in the first reagent R can be appropriately reduced. Since the generation of foam can be appropriately reduced, the measurement control function 93 using the first reagent dispensing probe 209 can appropriately detect the liquid level of the first reagent R. Since the liquid level of the first reagent R can be appropriately detected, the first reagent dispensing probe 209 can appropriately dispense the first reagent R. Furthermore, if the measurement control function 93 is configured to detect abnormalities associated with the generation of foam (for example, detecting abnormalities in the pressure of the first reagent R in the flow path connected to the first reagent dispensing probe 209, detecting abnormalities in the measurement results, etc.), the detection of such abnormalities and the occurrence of corresponding error processing can also be reduced. Thus, the throughput of the automatic analyzer 1 can be improved.

[0100] In the first embodiment, the stoppers 13A, 13B, 13C, and 13D are provided on the inner upper surface 111 of the reagent container 2042 so as to extend toward the bottom surface 121 of the reagent container 2042 .

[0101] Thus, the structure of the main body 12 side of the reagent container 2042 remains common, and the structure of the blocking parts 13A, 13B, 13C, and 13D provided on the cover 11 can be changed in design according to the conditions of rotation and stop of the first reagent reservoir 204, thereby reducing costs. In addition, since the blocking parts 13A, 13B, 13C, and 13D do not contact the bottom surface 121 of the reagent container 2042, they are different from the structure in which the blocking parts are provided on the bottom surface (for example, Figure 7 Compared with the comparative example), the corners on the bottom surface where the reagent is likely to remain can be reduced, and the dead space volume can be reduced.

[0102] In the first embodiment, the inner upper surface 111 is provided with a first reagent R removal port 14. Furthermore, the bottom surface 121 is inclined so as to move away from the inner upper surface 111 as it approaches the removal port 14. Furthermore, a plurality of blocking portions 13A, 13B, 13C, and 13D are provided at intervals in the direction of the rotation radius of the first reagent reservoir 204. Furthermore, the blocking portion closer to the removal port 14 among the plurality of blocking portions 13A, 13B, 13C, and 13D extends to a position D4 below the blocking portion farther from the removal port 14 among the plurality of blocking portions 13A, 13B, 13C, and 13D.

[0103] Thus, each of the dams 13A, 13B, 13C, and 13D can appropriately suppress rapid movement of the first reagent R, and thus foam generated in the first reagent R can be further appropriately reduced.

[0104] Furthermore, in the first embodiment, the width W of the dams 13A, 13B, 13C, and 13D in the rotation direction of the first reagent reservoir 204 decreases from the upper portion toward the lower portion of the dams 13A, 13B, 13C, and 13D.

[0105] Thus, by a simple structure of reducing the width W from the upper part to the lower part of the blocking parts 13A, 13B, 13C, and 13D, the gaps G1 and G2 between the blocking parts 13A, 13B, 13C, and 13D and the side surfaces 1221 and 1222 of the reagent containers can be formed to become larger from the upper part to the lower part of the blocking parts 13A, 13B, 13C, and 13D.

[0106] Furthermore, in the first embodiment, the widths W of the dam portions 13A, 13B, 13C, and 13D continuously decrease from the upper portions toward the lower portions of the dam portions 13A, 13B, 13C, and 13D.

[0107] Thus, by adopting a simpler structure in which the width W is continuously reduced from the upper part toward the lower part of the blocking parts 13A, 13B, 13C, and 13D, the gaps G1 and G2 between the blocking parts 13A, 13B, 13C, and 13D and the side surfaces 1221 and 1222 of the reagent containers can be formed to become larger from the upper part toward the lower part of the blocking parts 13A, 13B, 13C, and 13D.

[0108] In the first embodiment, the ends 131 and 132 of the blocking portions 13A, 13B, 13C, and 13D in the rotational direction of the first reagent storage 204 have a linear shape inclined with respect to the reagent container side surfaces 1221 and 1222 .

[0109] Thus, by having a simpler structure in which the ends 131 and 132 of the blocking parts 13A, 13B, 13C, and 13D have an inclined straight line shape, the gaps G1 and G2 between the blocking parts 13A, 13B, 13C, and 13D and the side surfaces 1221 and 1222 of the reagent containers can be formed to become larger from the upper part toward the lower part of the blocking parts 13A, 13B, 13C, and 13D.

[0110] In addition, in the first embodiment, the reagent container 2042 further includes a reinforcing portion 15 connected to the stoppers 13A, 13B, 13C, and 13D.

[0111] Thus, even if the width W of the stoppers 13A, 13B, 13C, 13D is locally reduced by changing the size of the gaps G1 and G2 in the vertical direction, the strength of the stoppers 13A, 13B, 13C, 13D can be appropriately ensured by the reinforcement 15 .

[0112] (First Modification)

[0113] Next, a first modified example of the first embodiment in which the widths W of the dam portions 13A, 13B, 13C, and 13D are made different will be described, focusing on the differences from the above-described embodiment. Figure 8 13A, 13B, 13C, and 13D of a reagent container 2042 according to a first modification of the first embodiment are shown.

[0114] exist Figure 8 In the illustrated example, the gaps G1 and G2 between the outer diameter side D2 of the plurality of stoppers 13A, 13B, 13C, and 13D and the reagent container side surfaces 1221 and 1222 are larger than the gaps G1 and G2 between the inner diameter side D1 of the plurality of stoppers 13A, 13B, 13C, and 13D and the reagent container side surfaces 1221 and 1222. Specifically, at the same height, the gaps G1 and G2 between the second stopper 13B and the reagent container side surfaces 1221 and 1222 are larger than the gaps G1 and G2 between the first stopper 13A and the reagent container side surfaces 1221 and 1222. Furthermore, at the same height, the gaps G1 and G2 between the third stopper 13C and the reagent container side surfaces 1221 and 1222 are larger than the gaps G1 and G2 between the second stopper 13B and the reagent container side surfaces 1221 and 1222. Furthermore, at the same height, the gaps G1 and G2 between the fourth blocking portion 13D and the reagent container side surfaces 1221 and 1222 are larger than the gaps G1 and G2 between the third blocking portion 13C and the reagent container side surfaces 1221 and 1222 .

[0115] That is, in Figure 8 In the illustrated example, the width W of the dam portion on the outer diameter side D2 of the plurality of dam portions 13A, 13B, 13C, and 13D is smaller than the width W of the dam portion on the inner diameter side D1 of the plurality of dam portions 13A, 13B, 13C, and 13D. Specifically, at the same height, the width W of the second dam portion 13B is smaller than the width W of the first dam portion 13A. Furthermore, at the same height, the width W of the third dam portion 13C is smaller than the width W of the second dam portion 13B. Furthermore, at the same height, the width W of the fourth dam portion 13D is smaller than the width W of the third dam portion 13C.

[0116] according to Figure 8 In the example shown, the gaps G1 and G2 between the blocking portion and the reagent container side surfaces 1221 and 1222 can be increased on the outer diameter side D2, where the flow rate and flow rate of the first reagent R are greater, thereby facilitating the movement of the first reagent R. This effectively reduces the occurrence of entrapment and the associated foaming. Furthermore, by employing a simple configuration in which the width W of the blocking portion is reduced on the outer diameter side D2, the gaps G1 and G2 between the blocking portion and the reagent container side surfaces 1221 and 1222 can be increased on the outer diameter side D2.

[0117] (Second Modification)

[0118] Next, modifications of the shapes of the end portions 131 and 132 of the dam portions 13A, 13B, 13C, and 13D will be described, focusing on differences from the above-described embodiment. Figure 9 It is a diagram showing the blocking portions 13A, 13B, 13C, and 13D of the reagent container 2042 according to the second modified example of the first embodiment.

[0119] exist Figure 5 In the example described above, the ends 131 and 132 of the stoppers 13A, 13B, 13C, and 13D in the rotation direction R1 of the reagent container 2042 have straight lines inclined relative to the reagent container side surfaces 1221 and 1222. Figure 9 In the example shown, the end portions 131 and 132 of the blocking portions 13A, 13B, 13C, and 13D have a curved shape that is inclined relative to the side surfaces 1221 and 1222 of the reagent container. Figure 9 In the illustrated example, the end portions 131 and 132 of the stoppers 13A, 13B, 13C, and 13D have a curved shape that bends outward.

[0120] In the second modified example, the gaps G1 and G2 between the blocking portions 13A, 13B, 13C, and 13D and the reagent container side surfaces 1221 and 1222 can also be configured to increase from the upper portion toward the lower portion of the blocking portions 13A, 13B, 13C, and 13D, thereby appropriately reducing foam generated in the first reagent R. Furthermore, the degree of freedom in the design of the blocking portions 13A, 13B, 13C, and 13D can be increased.

[0121] (Third Modification)

[0122] Next, other modified examples of the shapes of the end portions 131 and 132 of the dam portions 13A, 13B, 13C, and 13D will be described, focusing on the differences from the above-described embodiment. Figure 10 It is a diagram showing the blocking portions 13A, 13B, 13C, and 13D of the reagent container 2042 according to the third modified example of the first embodiment.

[0123] exist Figure 10 In the example shown, the end portions 131 and 132 of the blocking portions 13A, 13B, 13C, and 13D have a curved shape that is inclined relative to the side surfaces 1221 and 1222 of the reagent container. Figure 9 Different, in Figure 10 In the illustrated example, the end portions 131 and 132 of the stoppers 13A, 13B, 13C, and 13D have a curved shape that bends inward.

[0124] In the third modified example, the gaps G1 and G2 between the blocking portions 13A, 13B, 13C, and 13D and the reagent container side surfaces 1221 and 1222 can also be configured to increase from the upper portion toward the lower portion of the blocking portions 13A, 13B, 13C, and 13D, thereby appropriately reducing foam generated in the first reagent R. Furthermore, the degree of freedom in the design of the blocking portions 13A, 13B, 13C, and 13D can be increased.

[0125] (Fourth Modification)

[0126] Next, modifications of the width W of the dam portions 13A, 13B, 13C, and 13D will be described, focusing on differences from the above-described embodiment. Figure 11 It is a diagram showing the blocking portions 13A, 13B, 13C, and 13D of the reagent container 2042 according to the fourth modified example of the first embodiment.

[0127] exist Figure 5 In the example in which the width W of the barrier portions 13A, 13B, 13C, and 13D is continuously reduced from the upper portion to the lower portion of the barrier portions 13A, 13B, 13C, and 13D, is described. Figure 11 In the illustrated example, the width W of the stoppers 13A, 13B, 13C, and 13D decreases in stages from the upper portion toward the lower portion of the stoppers 13A, 13B, 13C, and 13D.

[0128] In the fourth modification, the gaps G1 and G2 between the blocking portions 13A, 13B, 13C, and 13D and the reagent container side surfaces 1221 and 1222 can also be configured to increase from the upper portion toward the lower portion of the blocking portions 13A, 13B, 13C, and 13D, thereby appropriately reducing foam generated in the first reagent R. Furthermore, the degree of freedom in the design of the blocking portions 13A, 13B, 13C, and 13D can be increased.

[0129] (Second embodiment)

[0130] Next, a second embodiment in which the stoppers 13A, 13B, 13C, and 13D are provided on the bottom surface 121 will be described, focusing on the differences from the above-described embodiment. Figure 12 It is a diagram showing the blocking portions 13A, 13B, 13C, and 13D of the reagent container 2042 according to the second embodiment.

[0131] In the first embodiment, the example in which the blocking portions 13A, 13B, 13C, and 13D are provided on the inner upper surface 111 of the reagent container 2042 has been described. Figure 12In the example shown, the blocking portions 13A, 13B, 13C, and 13D are provided on the bottom surface 121 of the reagent container 2042 so as to extend in a direction toward the inner upper surface 111 of the reagent container 2042 (i.e., upward D3). In other respects, the configuration of the blocking portions 13A, 13B, 13C, and 13D is similar to that of the first embodiment. Figure 5 The shown configuration is the same.

[0132] Figure 13 FIG. 2 is a diagram showing an example of the movement of the reagent in the reagent container 2042 according to the second embodiment. Figure 13 As shown, in the second embodiment, the gaps G1 and G2 between the blocking portions 13A, 13B, 13C, and 13D and the reagent container side surfaces 1221 and 1222 also increase from the upper portion to the lower portion of the blocking portions 13A, 13B, 13C, and 13D. As a result, when the rotation of the first reagent reservoir 204 stops, the first reagent R on the lower D4 side first returns to the inner diameter side D1 (step S2). This prevents the first reagent R on the upper D3 side from being drawn in (step S3).

[0133] Furthermore, similarly to the first embodiment, the first to fourth modified examples described above can also be applied to the dam portions 13A, 13B, 13C, and 13D in the second embodiment.

[0134] In the second embodiment, similar to the first embodiment, the gaps G1 and G2 between the blocking portions 13A, 13B, 13C, and 13D and the reagent container side surfaces 1221 and 1222 are formed to increase in size from the top to the bottom of the blocking portions 13A, 13B, 13C, and 13D. This allows the first reagent R on the lower side D4 to be moved first, thereby preventing the first reagent R from being drawn into the container. This can appropriately reduce the amount of foam generated by the first reagent R. Furthermore, the design freedom of the blocking portions 13A, 13B, 13C, and 13D can be increased.

[0135] According to at least one of the embodiments described above, foam generated in the reagent in the reagent container 2042 can be appropriately reduced.

[0136] The term "processor" used in the description of the embodiments means, for example, a CPU (Central Processing Unit), a GPU (Graphics Processing Unit), or an Application Specific Integrated Circuit (ASIC), a programmable logic device (such as a Simple Programmable Logic Device (SPLD), a Complex Programmable Logic Device (CPLD), and a Field Programmable Gate Array (FPGA)). The processor implements its functions by reading and executing the program stored in the storage circuit 8. In addition, instead of storing the program in the storage circuit 8, it is also possible to configure the program to be directly programmed into the circuit of the processor. In this case, the processor implements its functions by reading and executing the program loaded into the circuit. In addition, the processors of the above-mentioned embodiments are not limited to being configured as a single circuit for each processor, and multiple independent circuits can be combined to form one processor to implement its functions. Furthermore, multiple components in the above-mentioned embodiments can also be merged into one processor to implement its functions.

[0137] While several embodiments of the present invention have been described, these embodiments are provided as examples and are not intended to limit the scope of the invention. These embodiments can be implemented in various other ways and can be omitted, replaced, or modified without departing from the spirit of the invention. These embodiments and their variations are intended to be within the scope and spirit of the invention and are also intended to be within the scope of the invention set forth in the claims and their equivalents.

[0138] Description of Reference Numerals

[0139] 1Automatic analysis device

[0140] 111 internal upper surface

[0141] 121 Bottom

[0142] 1221 reagent container side

[0143] 1222 reagent container side

[0144] 13A first blocking portion

[0145] 13B second blocking portion

[0146] 13C third blocking part

[0147] 13D fourth blocking part

[0148] 131 end

[0149] 132 end

[0150] Exit 14

[0151] 15 Strengthening Department

[0152] 204 First Reagent Library

[0153] 2042 reagent container

Claims

1. A reagent container, provided in a rotating reagent reservoir of an automatic analysis device, The reagent container is provided with a blocking portion on the inner diameter side and the outer diameter side for partially blocking the rotation. The gap between the blocking portion and the side surface of the reagent container is configured to increase from an upper portion toward a lower portion of the blocking portion.

2. The reagent container according to claim 1, characterized in that The blocking portion is provided on the inner upper surface of the reagent container so as to extend toward the bottom surface of the reagent container.

3. The reagent container according to claim 1, characterized in that The blocking portion is provided on the bottom surface of the reagent container so as to extend toward the inner upper surface of the reagent container.

4. The reagent container according to claim 2, characterized in that A reagent removal port is provided on the inner upper surface. The bottom surface is inclined so as to be away from the inner upper surface as it approaches the removal port. The blocking parts are provided in plurality at intervals in the direction of the rotation radius of the reagent storage. Among the plurality of blocking portions, a blocking portion close to the removal opening extends to a position lower than a blocking portion far from the removal opening among the plurality of blocking portions.

5. The reagent container according to any one of claims 1 to 4, characterized in that The blocking parts are provided in plurality at intervals in the direction of the rotation radius of the reagent storage. A gap between the outer diameter side stopper among the plurality of stoppers and the side surface of the reagent container is larger than a gap between the inner diameter side stopper among the plurality of stoppers and the side surface of the reagent container.

6. The reagent container according to any one of claims 1 to 4, characterized in that The width of the blocking portion in the rotation direction of the reagent reservoir decreases from an upper portion toward a lower portion of the blocking portion.

7. The reagent container according to claim 6, characterized in that The blocking parts are provided in plurality at intervals in the direction of the rotation radius of the reagent storage. The width of the dam portion on the outer diameter side among the plurality of dam portions is smaller than the width of the dam portion on the inner diameter side among the plurality of dam portions.

8. The reagent container according to claim 6, characterized in that The width of the barrier portion continuously decreases from an upper portion toward a lower portion of the barrier portion.

9. The reagent container according to claim 8, characterized in that An end portion of the blocking portion in the rotational direction of the reagent reservoir has a linear shape inclined with respect to a side surface of the reagent container.

10. The reagent container according to claim 8, characterized in that An end portion of the blocking portion in a rotational direction of the reagent reservoir has a curved shape inclined relative to a side surface of the reagent container.

11. The reagent container according to claim 6, characterized in that The width of the barrier portion decreases in stages from an upper portion toward a lower portion of the barrier portion.

12. The reagent container according to claim 1, characterized in that The invention further comprises a reinforcing portion connected to the blocking portion.

13. The reagent container according to claim 9, characterized in that An angle formed by an end portion of the blocking portion in the rotational direction with respect to a side surface of the reagent container is greater than or equal to 2°.

14. The reagent container according to claim 9, characterized in that The side surface of the reagent container is a side surface having a direction intersecting with the rotation direction, The angle is larger than a second angle formed by the end of the blocking portion in the rotation radius direction relative to the side surface of the second reagent container oriented to intersect the rotation radius direction of the reagent reservoir.

15. An automatic analyzer comprising a rotating reagent reservoir and a reagent container disposed in the reagent reservoir. The reagent container includes a blocking portion on the inner diameter side and the outer diameter side inside the reagent container for partially blocking the rotation. The gap between the blocking portion and the side surface of the reagent container is configured to increase from an upper portion toward a lower portion of the blocking portion.

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