Duodenal-based electric field ablation methods, systems, and apparatuses

Abstract

Embodiments of the present application provide a duodenum-based electric field ablation method, system and device, the method comprising: in the case of determining a target tissue corresponding to a target object, determining the narrow pulse parameters required by the target tissue; wherein the target tissue is the position of the target object's duodenum that needs to be subjected to pulse electric field ablation; determining the state information of the main control system; detecting the state information, and in the case that the state information meets the preset condition, generating a first pulse and a second pulse based on the narrow pulse parameters through the driving of the H-bridge circuit; wherein the preset condition is that the state information of the main control system meets the preset state; performing phase shift control processing based on the first pulse and the second pulse to determine the narrow pulse corresponding to the narrow pulse parameters; and achieving electric field ablation of the target tissue through multiple electrodes based on the narrow pulse. In the above scheme, the stability of the output of the narrow pulse is improved, thereby improving the electric field ablation effect on the duodenum.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of medical electronics, in particular to a duodenum-based electric field ablation method, system and device. BACKGROUND

[0002] Pulse electric field ablation is a technology that causes cell death by applying a non-thermal, high-voltage pulse electric field on target tissue to form permanent electroporation on cell membranes. Control of pulse electric field ablation of the duodenum can accurately control the ablation area and reduce damage to surrounding healthy tissue, so that specific parts of the duodenum can be ablated without affecting the function of the entire organ.

[0003] At present, pulse electric field ablation of the duodenum uses narrow pulses. Due to the poor stability of the output of narrow pulses in the prior art, the effect of electric field ablation on the duodenum is not good. SUMMARY

[0004] The embodiments of the present application aim to provide a duodenum-based electric field ablation method, system and device that can improve the stability of the output of narrow pulses and improve the effect of electric field ablation on the duodenum.

[0005] The technical solution of the present application is as follows:

[0006] In a first aspect, the embodiments of the present application provide a duodenum-based electric field ablation method, which comprises:

[0007] In the case of determining the target tissue corresponding to the target object, the narrow pulse parameters required by the target tissue are determined; wherein the target tissue is the position of the duodenum of the target object that needs to be subjected to pulse electric field ablation;

[0008] The state information of the main control system is determined;

[0009] The state information of the main control system is detected, and in the case that the state information of the main control system reaches a preset condition, a first pulse and a second pulse are generated based on the narrow pulse parameters; wherein the preset condition is that the state information of the main control system reaches a preset state;

[0010] Based on the first pulse and the second pulse, a narrow pulse corresponding to the narrow pulse parameters is determined through phase shift control processing by an H-bridge circuit;

[0011] Based on the narrow pulse, electric field ablation of the target tissue is realized by multiple electrodes.

[0012] In the above scheme, the generation of the first pulse and the second pulse based on the narrow pulse parameters comprises:

[0013] configure a channel combination output state, timing information and a pulse output number of the driving H-bridge circuit based on the narrow pulse parameter;

[0014] generate the first pulse and the second pulse through the driving H-bridge circuit based on the channel combination output state, the timing information and the pulse output number.

[0015] In the scheme, the generation of the first pulse and the second pulse through the driving H-bridge circuit based on the channel combination output state, the timing information and the pulse output number comprises:

[0016] In the case of the channel combination output state being a first combination, the first pulse and the second pulse are generated; wherein the first combination is an A channel and a B channel; the first pulse is pulse A; and the second pulse is pulse B.

[0017] In the case of the channel combination output state being a second combination, the first pulse and the second pulse are generated; wherein the second combination is a C channel and a D channel; the first pulse is pulse C; and the second pulse is pulse D.

[0018] In the case of the channel combination output state being a third combination, the first pulse and the second pulse are generated; wherein the third combination is an A channel, a B channel, a C channel and a D channel; the first pulse is pulse A and pulse C; and the second pulse is pulse B and pulse D.

[0019] In the scheme, the determination of the narrow pulse corresponding to the narrow pulse parameter through the phase shift control processing of the H-bridge circuit based on the first pulse and the second pulse comprises:

[0020] In the case of the first pulse being pulse A and the second pulse being pulse B, a first phase difference of the pulse A and the pulse B is determined.

[0021] Based on the first phase difference, the pulse A and the pulse B are subjected to superposition processing through the H-bridge circuit to determine a high-voltage positive pulse.

[0022] The high-voltage positive pulse is determined as the narrow pulse corresponding to the narrow pulse parameter.

[0023] In the scheme, the determination of the narrow pulse corresponding to the narrow pulse parameter through the phase shift control processing of the H-bridge circuit based on the first pulse and the second pulse comprises:

[0024] In the case of the first pulse being pulse C and the second pulse being pulse D, a second phase difference of the pulse C and the pulse D is determined.

[0025] determining a high-voltage negative pulse based on the second phase difference and through phase shift control processing of the pulse C and the pulse D by the H-bridge circuit;

[0026] determining the high-voltage negative pulse as the narrow pulse corresponding to the narrow pulse parameter.

[0027] In the above scheme, the determination of the narrow pulse corresponding to the narrow pulse parameter based on the first pulse and the second pulse and through phase shift control processing by the H-bridge circuit comprises:

[0028] determining a first phase difference between the pulse A and the pulse B and a second phase difference between the pulse C and the pulse D in the case that the first pulse is the pulse A and the pulse C and the second pulse is the pulse B and the pulse D;

[0029] determining a high-voltage positive pulse based on the first phase difference and through superposition processing of the pulse A and the pulse B by the H-bridge circuit;

[0030] determining a high-voltage negative pulse based on the second phase difference and through phase shift control processing of the pulse C and the pulse D by the H-bridge circuit;

[0031] determining the high-voltage positive pulse and the high-voltage negative pulse as the narrow pulse corresponding to the narrow pulse parameter.

[0032] In the above scheme, the method further comprises:

[0033] performing system initialization on the main control system and the auxiliary control system respectively to determine state information of the main control system and state information of the auxiliary control system;

[0034] performing state detection, configuring a high-voltage power supply output parameter and sampling processing on the main control system to determine an output voltage; if the output voltage is greater than or equal to a preset voltage parameter, sending the state information corresponding to the main control system to the auxiliary control system through a main-auxiliary data communication module;

[0035] if the output voltage is less than the preset voltage parameter, updating the output voltage through parameter adjustment until the updated output voltage is greater than or equal to the preset voltage parameter, sending the state information corresponding to the main control system to the auxiliary control system through the main-auxiliary data communication module, and detecting the state information of the main control system by the auxiliary control system.

[0036] In the above scheme, the determination of the output voltage through state detection, configuration of the high-voltage power supply output parameter and sampling processing on the main control system comprises:

[0037] The main control system is detected and configured with high-voltage power output parameters to generate a PWM driving waveform;

[0038] Based on the PWM driving waveform, a high-voltage power supply generates high-voltage data; and the high-voltage data is sampled to obtain sampling data;

[0039] The sampling data is smoothed and filtered to determine voltage and current data;

[0040] If the voltage and current data represent an abnormality, an abnormality alarm is performed,

[0041] If the voltage and current data represent no abnormality, the output voltage is determined.

[0042] In a second aspect, the embodiments of the present application provide a duodenum-based electric field ablation system, comprising a determination unit and a generation unit;

[0043] The determination unit is configured to determine narrow pulse parameters required by a target tissue of a target object in a case where the target tissue is determined; wherein the target tissue is a part of the duodenum of the target object that needs to be subjected to pulse electric field ablation; and determine state information of a main control system.

[0044] The generation unit is configured to detect the state information of the main control system, and generate a first pulse and a second pulse based on the narrow pulse parameters in a case where the state information of the main control system meets a preset condition; wherein the preset condition is that the state information meets a preset state.

[0045] The determination unit is further configured to perform phase shift control processing on the first pulse and the second pulse through an H-bridge circuit to determine a narrow pulse corresponding to the narrow pulse parameters; and perform electric field ablation on the target tissue through multiple electrodes based on the narrow pulse.

[0046] In a third aspect, the embodiments of the present application provide a duodenum-based electric field ablation device, comprising a processor and a memory; wherein,

[0047] The memory is configured to store a computer program;

[0048] The processor is configured to call and run the computer program from the memory to execute the method of the first aspect.

[0049] The embodiment of the present application provides a duodenum-based electric field ablation method, system and device, the method comprises the following steps: in the case that a target tissue corresponding to a target object is determined, determining narrow pulse parameters required by the target tissue; wherein the target tissue is a position of the duodenum of the target object which needs to be subjected to pulse electric field ablation; determining state information of a main control system; detecting the state information, and in the case that the state information reaches a preset condition, generating a first pulse and a second pulse based on the narrow pulse parameters; wherein the preset condition is that the state information of the main control system reaches a preset state; performing phase shift control processing on the H-bridge circuit based on the first pulse and the second pulse, to determine a narrow pulse corresponding to the narrow pulse parameters; and performing electric field ablation on the target tissue through multiple electrodes based on the narrow pulse. In the above scheme, a narrower narrow pulse than the first pulse and the second pulse is generated through the first pulse and the second pulse. Since the first pulse and the second pulse can be stably output, the narrow pulse generated by superimposing the first pulse and the second pulse can also be stably output, so that the stability of the output of the narrow pulse can be improved. Since the stability of the output of the narrow pulse directly determines the effect of the electric field ablation of the duodenum, in the case that the stability of the output of the narrow pulse is improved, the electric field ablation effect on the duodenum can be improved. BRIEF DESCRIPTION OF DRAWINGS

[0050] The drawings incorporated in the specification and constituting a part of the specification illustrate embodiments consistent with the present application and, together with the specification, serve to explain the technical solutions of the present application. Obviously, the drawings in the following description are only some embodiments of the present application, and other drawings can also be obtained by those skilled in the art without creative effort on the basis of these drawings.

[0051] The flowchart shown in the drawings is only an exemplary description, and is not necessarily required to include all contents and operations / steps, and is not necessarily required to be executed in the order described. For example, some operations / steps can be further decomposed, and some operations / steps can be combined or partially combined, so that the actual execution order can be changed according to the actual situation.

[0052] Figure 1 An optional flowchart of a duodenum-based electric field ablation method provided by the embodiment of the present application;

[0053] Figure 2 A duodenum diagram of a duodenum-based electric field ablation method provided by the embodiment of the present application;

[0054] Figure 3 A duodenum treatment effect diagram of a duodenum-based electric field ablation method provided by the embodiment of the present application;

[0055] Figure 4 An optional H-bridge circuit schematic diagram of a duodenum-based electric field ablation method provided by an embodiment of the present application;

[0056] Figure 5 An optional H-bridge unit circuit schematic diagram of a duodenum-based electric field ablation method provided by an embodiment of the present application;

[0057] Figure 6 An optional phase-shifted narrow pulse schematic diagram of a duodenum-based electric field ablation method provided by an embodiment of the present application;

[0058] Figure 7 An optional drive control software flowchart of a duodenum-based electric field ablation method provided by an embodiment of the present application;

[0059] Figure 8 An optional system framework schematic diagram of a duodenum-based electric field ablation method provided by an embodiment of the present application;

[0060] Figure 9 An optional high-voltage circuit schematic diagram of a duodenum-based electric field ablation method provided by an embodiment of the present application;

[0061] Figure 10 An optional sampling isolation circuit schematic diagram of a duodenum-based electric field ablation method provided by an embodiment of the present application;

[0062] Figure 11 A structural schematic diagram of a duodenum-based electric field ablation system provided by an embodiment of the present application;

[0063] Figure 12 A structural schematic diagram of a duodenum-based electric field ablation device provided by an embodiment of the present application. DETAILED DESCRIPTION

[0064] In order to make the objectives, technical solutions and advantages of the embodiments of the present application clearer, the following will further describe the specific technical solutions of the present application with reference to the accompanying drawings in the embodiments of the present application. The following embodiments are used to explain the present application, but are not used to limit the scope of the present application.

[0065] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. The terminology used in the description herein is for describing the embodiments of the present application only and is not intended to limit the present application.

[0066] In the following description, "some embodiments", "this embodiment", "embodiments of the present application" and the like refer to all possible embodiments, but it is understood that "some embodiments" can be the same or different from each other, and can be combined with each other without conflict.

[0067] If similar descriptions of "first / second" appear in the application file, the following description is added. In the following description, the terms "first, second, third" refer to similar objects only, and do not represent a specific order of the objects. It is understood that "first, second, third" can be interchanged in a specific order or sequence as allowed, so that the embodiments of the present application described herein can be implemented in an order other than that illustrated or described herein.

[0068] Based on this, the embodiments of the present application provide a duodenal-based electric field ablation method, Figure 1 An optional flowchart of a duodenal-based electric field ablation method provided by the embodiments of the present application will be described in combination with Figure 1 The steps shown will be described.

[0069] S101, in the case of determining the target tissue corresponding to the target object, determining the narrow pulse parameters required by the target tissue; wherein the target tissue is the position of the duodenum of the target object which needs to be subjected to pulse electric field ablation.

[0070] In some embodiments of the present application, there is a rich nervous system in the human intestinal tract, which is called "gut brain". Duodenal electric field ablation acts on the submucosal nerve plexus of the duodenum through electric field of specific frequency and intensity, and regulates the function of the intestinal nervous system. Through this electric field intervention, the abnormality of intestinal nerve conduction can be corrected, the secretion regulation of gastrointestinal hormones can be improved, and then a positive influence on blood glucose metabolism can be produced. For example, it can regulate the gastric emptying speed, avoid the adverse effects of too fast or too slow gastric emptying on blood glucose, and make the change of blood glucose more stable.

[0071] In some embodiments of the present application, there are various endocrine cells in the duodenal mucosa, such as L cells, K cells, etc., which secrete hormones such as glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), etc., which play a key role in blood glucose regulation. Electric field ablation can stimulate the endocrine cells of the duodenal mucosa, increase the secretion of GLP-1, GIP and other intestinal insulinotropins. These hormones can promote the secretion of insulin by pancreatic beta cells, inhibit the secretion of glucagon, and enhance the sensitivity of insulin, thereby helping to reduce blood glucose levels.

[0072] In some embodiments of the present application, the duodenal electric field ablation can affect the composition and distribution of intestinal flora by changing the microecological environment in the intestinal tract. Studies have found that this method can increase the number of beneficial bacteria such as Bifidobacterium and Lactobacillus, and reduce the number of harmful bacteria such as Enterobacteriaceae. Beneficial bacteria can participate in various metabolic processes, produce beneficial substances such as short-chain fatty acids, and help improve insulin sensitivity and regulate glucose metabolism. At the same time, changes in intestinal flora can also affect intestinal barrier function, reduce the production and absorption of endotoxins, reduce systemic inflammatory response, and indirectly improve blood glucose control.

[0073] In some embodiments of the present application, the duodenal electric field ablation device determines the narrow pulse parameters required by the target tissue in the case of determining the target tissue corresponding to the target object.

[0074] In some embodiments of the present application, the target object is generally a user who needs duodenal treatment, and the target tissue is the position of the duodenum of the target object that needs to be subjected to pulse electric field ablation.

[0075] In some embodiments of the present application, the duodenal electric field ablation method is suitable for the scenario of ablation of the mucosa in the duodenum.

[0076] In some embodiments of the present application, the execution subject of the duodenal electric field ablation method is a duodenal electric field ablation device. The duodenal electric field ablation device can be a terminal device, and the terminal device includes a main control system and an auxiliary control system. The main control system and the auxiliary control system can interact through a main- auxiliary data communication module.

[0077] In some embodiments of the present application, the duodenal electric field ablation device can obtain the tissue image of the duodenum of the target object through an image acquisition device, perform image recognition on the tissue image, and determine the target tissue. Through the target tissue, the electric field intensity and the pulse sequence are calculated, and the narrow pulse parameters required by the target tissue are determined.

[0078] S102, determine the state information of the main control system.

[0079] In some embodiments of the present application, the state information of the main control system includes the states of the PWM module, the ADC sampling module, and the main- auxiliary data communication module.

[0080] In some embodiments of the present application, the main control system and the auxiliary control system are respectively initialized to determine the state information of the main control system and the state information of the auxiliary control system. The main control system is subjected to state detection, configuration of high-voltage power supply output parameters, and sampling processing to determine the output voltage. If the output voltage is greater than or equal to the preset voltage parameter, the state information of the main control system is sent to the auxiliary control system through the main- auxiliary data communication module.

[0081] It should be noted that the state information of the main control system sent to the auxiliary control system is the determined state information of the main control system.

[0082] S103, detecting the state information of the main control system, and generating the first pulse and the second pulse based on the narrow pulse parameter in the case that the state information of the main control system reaches a preset condition; wherein the preset condition is that the state information of the main control system reaches a preset state.

[0083] In some embodiments of the present application, the preset condition is that the state information of the main control system reaches a preset state. The preset state is a state in which the H-bridge circuit can be driven.

[0084] In some embodiments of the present application, the duodenum-based electric field ablation device detects the state information, and in the case that the state information reaches a preset condition, the channel combination output state, the timing information and the pulse output number of the driving H-bridge circuit are configured based on the narrow pulse parameter. Based on the channel combination output state, the timing information and the pulse output number, the first pulse and the second pulse are generated through the driving H-bridge circuit.

[0085] It should be noted that the channel combination can be any one of the first combination, the second combination and the third combination, the first combination is the channel A and the channel B; the second combination is the C channel and the D channel; the third combination is the A channel, the B channel, the C channel and the D channel. The pulse output number can be 2 or 4.

[0086] In some embodiments of the present application, the first pulse and the second pulse can each include one pulse or two pulses.

[0087] S104, based on the first pulse and the second pulse, the H-bridge circuit is phase-shifted to control and process to determine the narrow pulse corresponding to the narrow pulse parameter.

[0088] In some embodiments of the present application, the duodenum-based electric field ablation device can calculate the phase difference between the first pulse and the second pulse through the phase of the first pulse and the phase of the second pulse; based on the phase difference between the first pulse and the second pulse, the H-bridge circuit is phase-shifted to control and process to determine the narrow pulse corresponding to the narrow pulse parameter.

[0089] S105, based on the narrow pulse, the electric field ablation of the target tissue is realized through the multi-electrode.

[0090] In some embodiments of the present application, the duodenum-based electric field ablation device can perform electric field ablation on the target tissue of the target object through the multi-electrode on the duodenum-based electric field ablation device according to the generated narrow pulse.

[0091] An exemplary duodenum-based electric field ablation method includes: 1, first use an endoscope to reach the duodenum site; 2, place a guide wire through the endoscope lumen to the duodenum; 3, guide the ablation catheter to the duodenal horizontal segment through the guide wire; 4, start ablation, generally 8cm in length, single ablation area is limited, so multiple ablation is needed; 5, endoscopic observation is needed during ablation to facilitate operation of the ablation catheter; 6, after ablation is completed, the endoscope, ablation catheter and guide wire are pulled out together. As shown in Figure 2 and 3 As shown in Figure 2 is an image of the duodenum before electric field ablation, Figure 3 is an image of the duodenum tissue after electric field ablation, as shown in Figure 3 the ablation area is clearly visible, and the cell slice effect is obvious.

[0092] It can be understood that a narrow pulse narrower than the first pulse and the second pulse is generated by the first pulse and the second pulse, and since the first pulse and the second pulse can be stably output, the narrow pulse generated by superimposition of the first pulse and the second pulse can also be stably output, thereby improving the stability of the output of the narrow pulse. Since the stability of the output of the narrow pulse directly determines the effect of the electric field ablation of the duodenum, in the case of improving the stability of the output of the narrow pulse, the electric field ablation effect on the duodenum can be improved. In addition, the duodenum wall is about 4mm thick, and the mucosa layer is 0.3-0.5mm. First, the duodenum wall is very thin, other surgeries are risky, and the effective target site for ablation is the mucosa layer. However, electric field ablation is safer than other surgeries, and the narrow pulse generated by the phase shift principle has stable pulses and high repetition accuracy. The ablation under this technology can control the ablation accuracy to 0.1mm, which can greatly improve the treatment effect while ensuring the treatment effect.

[0093] In some embodiments of the present application, S103 can be implemented by S1031 and S1032, as follows:

[0094] S1031, based on the narrow pulse parameters, configure the channel combination output state, timing information and pulse output number of the driving H-bridge circuit.

[0095] In some embodiments of the present application, the channel combination output state includes channel combinations between different quadrants; the timing information is the time of the trigger pulse between different channels.

[0096] In some embodiments of the present application, based on the narrow pulse parameters, the channel combination output state, timing information and pulse output number of the driving H-bridge circuit are configured. Exemplarily, as shown in Figure 4As shown, the H-bridge circuit working area is divided into four quadrants, A (A+ / A-), B (B+ / B-), C (C+ / C-), and D (D+ / D-). When the A and B quadrants are turned on, the current flows from HV+ to HV- through QB1, the load, and QB2, and the load current is L1 to L2, generating a positive pulse. Similarly, when the C and D quadrants are turned on, the current flows from HV+ to HV- through QB3, the load, and QB4, and the load current is L2 to L1, generating a negative pulse.

[0097] S1032, based on the channel combination output state, the timing information, and the number of pulse outputs, generate a first pulse and a second pulse.

[0098] In some embodiments of the present application, when the channel combination output state is a first combination, a first pulse and a second pulse are generated; wherein the first combination is the A channel and the B channel; the first pulse is pulse A; and the second pulse is pulse B.

[0099] In some embodiments of the present application, when the channel combination output state is a second combination, a first pulse and a second pulse are generated; wherein the second combination is the C channel and the D channel; the first pulse is pulse C; and the second pulse is pulse D.

[0100] In some embodiments of the present application, when the channel combination output state is a third combination, a first pulse and a second pulse are generated; wherein the third combination is the A channel, the B channel, the C channel, and the D channel; the first pulse is pulse A and pulse C; and the second pulse is pulse B and pulse D.

[0101] In some embodiments of the present application, S104 can be implemented through S1041, S1042, and S1043, as follows:

[0102] S1041, in the case where the first pulse is pulse A and the second pulse is pulse B, determining a first phase difference of pulse A and pulse B.

[0103] In some embodiments of the present application, in the case where the first pulse is pulse A and the second pulse is pulse B, the time of pulse A and the time of pulse B are determined, and the first phase difference of pulse A and pulse B is calculated based on the time of pulse A and the time of pulse B.

[0104] S1042, based on the first phase difference, superimposing pulse A and pulse B through the H-bridge circuit to determine a high-voltage positive pulse.

[0105] In some embodiments of the present application, the conduction time of the H-bridge circuit is determined through the first phase difference, and the superimposition of pulse A and pulse B is performed based on the conduction time to determine the high-voltage positive pulse.

[0106] For example, Figure 4The H-bridge circuit shown is composed of Figure 5 The unit shown, the control signal adopts a pair of differential signal pair optocoupler control, when the optocoupler is turned on, RB2, IGBT and the internal chip constitute a conduction loop, IGBT is turned on; when the optocoupler is turned off, RB3, DB1, IGBT and the internal chip constitute a turn-off loop, IGBT is turned off. As shown in Figure 3 It can be seen that when A and B are all turned on, the H-bridge generates a positive pulse, and when C and D are all turned on, the H-bridge generates a negative pulse; it is difficult for a conventional control system to generate a stable narrow pulse, such as ns level, which can be generated by the principle of phase shift to generate the required pulse width, which not only reduces the system requirements, but also improves the effect of electric field ablation. As shown in Figure 6 As shown, after the output of pulses A and B, a certain phase is generated, so that a smaller pulse (t3-t2) can be generated in the superposition section. The pulse time can make H-bridge A and B all conduct, and the control pulse width after synthesis is narrower than that of pulses A and B itself, so a narrower high-voltage positive pulse can be output, as shown in Figure 6 As shown, the positive pulse A.

[0107] S1043, determining the high-voltage positive pulse as a narrow pulse corresponding to the narrow pulse parameter.

[0108] It can be understood that a narrower narrow pulse than pulse A and pulse B is generated by pulse A and pulse B. Since pulse A and pulse B can be stably output, the high-voltage positive pulse generated by the superposition of pulse A and pulse B can also be stably output, thereby improving the stability of the output of the narrow pulse.

[0109] In some embodiments of the present application, S104 can also be implemented by S1044, S1045 and S1046, as follows:

[0110] S1044, in the case where the first pulse is pulse C and the second pulse is pulse D, determining the second phase difference of pulse C and pulse D.

[0111] In some embodiments of the present application, in the case where the first pulse is pulse C and the second pulse is pulse D, the time of pulse C and the time of pulse D are determined, and the second phase difference of pulse C and pulse D is calculated according to the time of pulse C and the time of pulse D.

[0112] S1045, based on the second phase difference, performing phase shift control processing on pulse C and pulse D through the H-bridge circuit to determine the high-voltage negative pulse.

[0113] In some embodiments of the present application, the conduction time of the H-bridge circuit is determined through the second phase difference, and the high-voltage negative pulse is determined by superimposing pulse C and pulse D based on the conduction time.

[0114] For example, as shown inFigure 6 As shown, after the output of pulses C and D, a certain phase is generated, so that a smaller pulse (t3'-t2') can be generated in the superposition section, and the pulse time can make H-bridge C and D fully conduct. Compared with pulses C and D themselves, the width of the synthesized control pulse is narrower, so a narrower high-voltage negative pulse can be output, such as Figure 6 As shown, negative pulse B.

[0115] S1046, determining the high-voltage negative pulse as the narrow pulse corresponding to the narrow pulse parameter.

[0116] It can be understood that a narrower narrow pulse than pulses C and D is generated by pulses C and D. Since pulses C and D can be stably output, the high-voltage negative pulse generated by the superposition of pulses C and D can also be stably output, thereby improving the stability of the output of the narrow pulse.

[0117] In some embodiments of the present application, S104 can also be implemented by S1047, S1048, S1049 and S10410, as follows:

[0118] S1047, in the case where the first pulse is pulse A and pulse C, and the second pulse is pulse B and pulse D, determining the first phase difference of pulse A and pulse B, and the second phase difference of pulse C and pulse D.

[0119] In some embodiments of the present application, in the case where the first pulse is pulse A and pulse C, and the second pulse is pulse B and pulse D, the time of pulse A and the time of pulse B are determined, and the first phase difference of pulse A and pulse B is calculated according to the time of pulse A and the time of pulse B; the time of pulse C and the time of pulse D are determined, and the second phase difference of pulse C and pulse D is calculated according to the time of pulse C and the time of pulse D.

[0120] S1048, based on the first phase difference, superimposing pulse A and pulse B through the H-bridge circuit to determine the high-voltage positive pulse.

[0121] S1049, based on the second phase difference, phase-shifting control processing of pulse C and pulse D through the H-bridge circuit to determine the high-voltage negative pulse.

[0122] S10410, determining the high-voltage positive pulse and the high-voltage negative pulse as the narrow pulse corresponding to the narrow pulse parameter.

[0123] It can be understood that, through the pulse A and the pulse B, a narrower pulse than the pulse A and the pulse B is generated, through the pulse C and the pulse D, a narrower pulse than the pulse C and the pulse D is generated, since the pulse A and the pulse B can be stably output, therefore, the high-voltage positive pulse generated by superimposition of the pulse A and the pulse B can also be stably output, the high-voltage negative pulse generated by superimposition of the pulse C and the pulse D can also be stably output, so as to be able to improve the stability of the output of the narrow pulse.

[0124] In some embodiments of the present application, the duodenum-based electric field ablation method further comprises:

[0125] S201, system initialization is performed on the main control system and the auxiliary control system respectively, and state information of the main control system and state information of the auxiliary control system are determined.

[0126] In some embodiments of the present application, system initialization is performed on the main control system and the auxiliary control system respectively, specifically, each unit used by the main control system is initialized, and each unit used by the auxiliary control system is initialized, and state information of the main control system and state information of the auxiliary control system are determined.

[0127] For example, each unit used by the main control system includes a PWM module, an ADC sampling module, and a main-aid data communication module, and at the same time, the unit modules required by the PIC auxiliary control unit (i.e. the auxiliary control system) such as a PWM control module, an ADC sampling module, and a main-aid communication module.

[0128] S202, state detection is performed on the main control system, output parameters of the high-voltage power supply are configured, and sampling processing is performed, and output voltage is determined; if the output voltage is greater than or equal to a preset voltage parameter, the state information corresponding to the main control system is sent to the auxiliary control system through the main-aid data communication module.

[0129] In some embodiments of the present application, state detection is performed on the main control system, output parameters of the high-voltage power supply are configured, and sampling processing is performed, and output voltage is determined; if the output voltage is greater than or equal to a preset voltage parameter, the state information corresponding to the main control system is sent to the auxiliary control system through the main-aid data communication module.

[0130] In some embodiments of the present application, state detection is performed on the main control system, output parameters of the high-voltage power supply are configured, and sampling processing is performed, and output voltage is determined; if the output voltage is greater than or equal to a preset voltage parameter, the state information corresponding to the main control system is sent to the auxiliary control system through the main-aid data communication module.

[0131] State detection is performed on the main control system, and output parameters of the high-voltage power supply are configured, and a PWM driving waveform is generated;

[0132] Based on the PWM driving waveform, high-voltage data is generated by driving the high-voltage power supply; and sampling processing is performed on the high-voltage data to obtain sampling data;

[0133] The voltage and current data is smoothed and filtered to determine the data;

[0134] If the voltage and current data indicates an abnormality, an abnormality alarm is performed,

[0135] If the voltage and current data indicates no abnormality, the output voltage is determined.

[0136] As shown in the example, Figure 7 As shown in the example, after the system is running, the PIC master will perform system initialization. In the initialization stage, each unit used by the system will be initialized, such as the PWM module, the ADC sampling module, the master-slave data communication module, and the master unit log information output module function initialization. At the same time, the PIC auxiliary control unit will also perform system initialization, which is used to initialize the unit modules required by the auxiliary control, such as the PWM control module, the ADC sampling module, the master-slave communication module, etc. After initialization is completed, the PIC master and the PIC auxiliary control will establish communication through the master-slave data communication module and perform state interaction. Then the PIC master will configure the high-voltage power supply output parameters, such as the expected output target voltage and current limit. After configuring the high-voltage power supply parameters, the PWM module will be configured to generate a PWM waveform with a specific frequency and duty cycle, which is used to drive the high-voltage power supply to generate high voltage. After the PWM is generated, the ADC sampling module will sample the generated high-voltage data such as high-voltage value and current, and perform smoothing and filtering processing on the collected voltage and current data, so as to filter individual jitter data and make the data stable. After data processing, the data will be analyzed to determine whether the data is abnormal, such as no output of high voltage or inability to detect current. When this abnormality occurs, an abnormality alarm will be performed to inform the user. If the voltage and current data is within the normal range, the data will be compared with the preset voltage parameters to determine whether the output voltage is consistent with the expected output voltage. If there is a deviation between the output voltage parameter and the expectation, the voltage will be adjusted by PID parameters until the output voltage parameter is consistent with the expectation. Then the PIC auxiliary control will also be informed of the master control state information through the master-slave data communication, so that the auxiliary control can perform H-bridge circuit driving control.

[0137] After the PIC auxiliary controller obtains the expected voltage parameters of the PIC master controller via master-slave data communication and performs H-bridge drive control output, it continuously monitors the conduit temperature through the ADC sampling module and triggers H-bridge drive control. The H-bridge drive control triggering process is as follows: The PIC auxiliary controller configures the PWM drive output module, configuring the combined output status, timing information, and number of pulse outputs for channels A and B. Then, channels A and B are enabled, generating pulse A. After a specified clock cycle, pulse B is generated at the output. The overlapping portion of pulse A and pulse B is the synthesized pulse output, i.e., positive pulse A. Similarly, after a specified clock cycle, by configuring the combined output status, timing information, and number of pulse outputs for channels C and D, and then enabling channels C and D, pulse C is generated at the output. After a specified number of clock cycles, pulse D is generated at the output. The overlapping portion of pulse C and pulse D is the synthesized pulse output, i.e., negative pulse B. After the pulse output is completed, the PIC master controller is informed of the relevant status information via master-slave data communication, completing the H-bridge circuit drive control process.

[0138] This application also provides an electric field ablation system based on the duodenum, such as... Figure 8 As shown, the duodenal-based electric field ablation system mainly consists of an AC-DC converter, which converts mains power into low-voltage electricity for power supply and control of the low-voltage system. At the same time, the boost system converts the low-voltage electricity into high-voltage electricity for electric field ablation. The control system is implemented by two PIC32 microcontrollers: a main control system and an auxiliary system. The main control system is used for voltage acquisition, high-voltage power supply control, and information output. The auxiliary control system is used to control the H-bridge circuit to generate unipolar or bipolar high-voltage pulses. Signal control and transmission use optocouplers or electric field isolation to ensure the safety of the patient.

[0139] A boost system can be implemented using a high-voltage circuit, such as... Figure 9 As shown, after a low-voltage DC input, the voltage is filtered and stored by CC1, DC1 is used for overvoltage protection, and the voltage regulator circuit supplies power to the power supply PWM control and output monitoring unit. The high-voltage power supply system adopts a flyback topology, which converts the low-voltage electricity into a maximum 3kV DC high-voltage electricity through transformer boosting and diode capacitor voltage multiplication. RC6 and RC7 are used for current sampling and current limiting; RC2 and RC4 are used for high-voltage current feedback, which can accurately control the high-voltage output; RC3 and RC5 are used for sampling the actual output voltage to ensure that the set voltage and the actual output voltage are consistent. At the same time, in order to ensure safe use and good EMC characteristics, the high-voltage ground is connected to ground in parallel through RC8 and CC3. RC8 can provide DC grounding, and CC3 can provide AC grounding.

[0140] The front-end current sampling uses a Kelvin connection for direct acquisition, separating the power terminal (I+ / I-) and the signal terminal (R+ / R-) to avoid sampling errors caused by line resistance and soldering issues. Low-temperature drift alloy resistors are also used to avoid temperature-induced sampling errors. Optical isolation is used for current isolation. Optical isolation is low-cost, has strong anti-interference capabilities, and high linearity; however, conventional linear optocouplers typically isolate signals only in one direction, making AC signal acquisition circuitry complex and costly. After improvement and optimization, the system presets a DC level at the output of the differential amplifier, such as... Figure 10 The Vref shown indicates that the acquired AC signal output fluctuates around a preset level, thus achieving the purpose of AC signal acquisition.

[0141] Acquisition circuit, such as Figure 10 As shown, the acquisition circuit is divided into two stages of amplification: the first stage is a fully differential amplifier circuit composed of U1 and U2, and R7 and R8 are grounded to ensure that the amplitudes at both ends of the output are consistent; the second stage is a differential circuit composed of U3 and external resistors.

[0142] 1) For the first stage of amplification, based on the characteristics of the operational amplifier operating in the linear region, the voltage after amplification is calculated according to equation (1).

[0143]

[0144] In the formula: V S Ix is the differential input voltage, Ix is the current in the differential amplifier circuit, and U0 is the voltage. o+ and V o- The amplified voltage difference.

[0145] 2) For the second-stage amplification, the input section of U3 has two excitation sources at the positive terminal and one excitation source at the negative terminal. According to the voltage superposition theorem and the characteristics of operational amplifiers operating in the linear region, when each excitation source acts independently, the other excitation sources are grounded. The outputs of each excitation source are superimposed to obtain the final output V. out The value of V1 is derived by equation (2) when the negative terminal Vo- of U3 is used alone; when the positive terminals Vo+ and Vref of U3 are used, the output V2 of U3 is derived by equation (3).

[0146]

[0147] In the formula: V o1+ For V o+ and V ref The voltage applied to the positive terminal of U3, Io is the current in the feedback loop, and V2 is the total output voltage of the two excitations at the positive terminal.

[0148] From equations (2) and (3), we can obtain:

[0149]

[0150] In the formula: V1 is the output voltage of U3 negative terminal Vo- excitation, V2 is U3 positive terminal V o+ and V ref excitation. If the output voltage has equal proportion differential form, it must meet:

[0151]

[0152] Arranging formula (4) and formula (5), we can get:

[0153]

[0154] Set R9 = R11 = R10 = R12, so that the second stage amplifier output only differential function, no amplification.

[0155] Optocoupler isolation circuit, such as Figure 10 shown, isolation optocoupler HCNR200 is selected by PD1, PD2 and LED, isolation circuit R21 input voltage is V in2 (equal to the output of the sampling circuit V out ), the output voltage of operational amplifier IC2A is V out2 , LED current is I F , according to the gain transfer coefficient definition and device technical data can know:

[0156]

[0157] In the formula: I PD1_max is the maximum gain current of PD1, I PD2_max is the maximum gain current of PD2, K1, K2 and K3 are the transfer gain coefficient.

[0158] According to the basic characteristics of operational amplifier working in linear region, the current I PD1 and I PD2 flowing through PD1 and PD2 are calculated by formula (8):

[0159]

[0160] According to the constraint condition of formula (7) and formula (8), the relationship between the output voltage V out2 and the input voltage V in2 of operational amplifier IC2A is shown in formula (9):

[0161]

[0162] According to the technical data of optocoupler, the typical value of K3 is 1. In order to achieve the purpose of isolation only, let R 21 = R 23At this point, the isolation section is a 1:1 isolation circuit, and then the isolated signal is sent to the ADC conversion circuit. S203, if the output voltage is less than the preset voltage parameter, the output voltage is updated by adjusting the parameters until the updated output voltage is greater than or equal to the preset voltage parameter. The status information of the main control system is sent to the auxiliary control system through the main-auxiliary data communication module; the status information of the main control system is detected by the auxiliary control system.

[0163] Understandably, the phase-shifting sampling software generates narrow pulses. This method reduces system performance requirements while producing high-voltage pulses suitable for treatment, significantly improving system cost and reliability. Using an H-bridge phase-controlled method to generate bipolar pulses, which typically requires both positive and negative power supplies, allows for single-supply generation, reducing system design complexity and difficulty. The sampling circuit uses four terminals and Kelvin sampling resistors and methods, enabling more accurate testing of the system's output power, which is crucial for output energy control. Differential sampling and linear optical coupling are used to isolate and significantly reduce interference from the strong interference of the high-voltage pulse field, ensuring sampling accuracy and improving treatment efficacy.

[0164] Based on the duodenal-based electric field ablation method described in the above embodiments, this application also provides a duodenal-based electric field ablation system, such as... Figure 11 As shown, Figure 11 This application provides a schematic diagram of the structure of an electric field ablation system based on the duodenum. The electric field ablation system 11 based on the duodenum includes: a determining unit 1101 and a generating unit 1102, wherein...

[0165] The determining unit 1101 is used to determine the narrow pulse parameters required for the target tissue when the target tissue corresponding to the target object is determined; wherein, the target tissue is the location of the duodenum of the target object that needs to be ablated by pulsed electric field; and to determine the status information of the main control system;

[0166] The generation unit 1102 is used to detect the state information of the main control system, and generate a first pulse and a second pulse based on the narrow pulse parameters when the state information of the main control system reaches a preset condition; wherein, the preset condition is that the state information of the main control system reaches a preset state.

[0167] The determining unit 1101 is further configured to determine the narrow pulse corresponding to the narrow pulse parameter by performing phase shift control processing through an H-bridge circuit based on the first pulse and the second pulse; and to realize electric field ablation of the target tissue through multiple electrodes based on the narrow pulse.

[0168] In some embodiments of the present application, the duodenum-based electric field ablation system 11 further comprises: a configuration unit 1103; wherein

[0169] The configuration unit 1103 is configured to configure, based on the narrow pulse parameters, a channel combination output state, timing information, and a pulse output number of the driving H-bridge circuit.

[0170] The generation unit 1102 is further configured to generate, based on the channel combination output state, the timing information, and the pulse output number, the first pulse and the second pulse through the driving H-bridge circuit.

[0171] In some embodiments of the present application, the generation unit 1102 is further configured to generate the first pulse and the second pulse in a case where the channel combination output state is a first combination; wherein the first combination is an A channel and a B channel; the first pulse is pulse A; the second pulse is pulse B; generate the first pulse and the second pulse in a case where the channel combination output state is a second combination; wherein the second combination is a C channel and a D channel; the first pulse is pulse C; the second pulse is pulse D; generate the first pulse and the second pulse in a case where the channel combination output state is a third combination; wherein the third combination is an A channel, a B channel, a C channel, and a D channel; the first pulse is pulse A and pulse C; the second pulse is pulse B and pulse D.

[0172] In some embodiments of the present application, the determination unit 1101 is further configured to, in a case where the first pulse is pulse A and the second pulse is pulse B, determine a first phase difference between the pulse A and the pulse B; based on the first phase difference, perform superposition processing on the pulse A and the pulse B through the H-bridge circuit to determine a high-voltage positive pulse; and determine the high-voltage positive pulse as the narrow pulse corresponding to the narrow pulse parameters.

[0173] In some embodiments of the present application, the determination unit 1101 is further configured to, in a case where the first pulse is pulse C and the second pulse is pulse D, determine a second phase difference between the pulse C and the pulse D; based on the second phase difference, perform phase shift control processing on the pulse C and the pulse D through the H-bridge circuit to determine a high-voltage negative pulse; and determine the high-voltage negative pulse as the narrow pulse corresponding to the narrow pulse parameters.

[0174] In some embodiments of the present application, the determination unit 1101 is further configured to, in the case that the first pulse is pulse A and pulse C, and the second pulse is pulse B and pulse D, determine a first phase difference between the pulse A and the pulse B, and a second phase difference between the pulse C and the pulse D; perform superposition processing on the pulse A and the pulse B through the H-bridge circuit based on the first phase difference to determine a high-voltage positive pulse; perform phase shift control processing on the pulse C and the pulse D through the H-bridge circuit based on the second phase difference to determine a high-voltage negative pulse; and determine the high-voltage positive pulse and the high-voltage negative pulse as the narrow pulse corresponding to the narrow pulse parameter.

[0175] In some embodiments of the present application, the determination unit 1101 is further configured to perform system initialization on a main control system and an auxiliary control system respectively, and determine state information of the main control system and state information of the auxiliary control system; perform state detection, configuration of high-voltage power supply output parameters, and sampling processing on the main control system to determine an output voltage; if the output voltage is greater than or equal to a preset voltage parameter, send the state information corresponding to the main control system to the auxiliary control system through a main- auxiliary data communication module; if the output voltage is less than the preset voltage parameter, update the output voltage through parameter adjustment until the updated output voltage is greater than or equal to the preset voltage parameter, and then send the state information corresponding to the main control system to the auxiliary control system through the main- auxiliary data communication module; and detect the state information of the main control system through the auxiliary control system.

[0176] In some embodiments of the present application, the duodenum-based electric field ablation system 11 further comprises a sampling unit 1104; wherein,

[0177] The generation unit 1102 is further configured to perform state detection on the main control system and configuration of high-voltage power supply output parameters to generate a PWM driving waveform; and drive the high-voltage power supply to generate high-voltage data based on the PWM driving waveform.

[0178] The sampling unit 1104 is configured to perform sampling processing on the high-voltage data to obtain sampling data.

[0179] The determination unit 1101 is further configured to perform smoothing filtering processing on the sampling data to determine voltage and current data; if the voltage and current data represent an abnormality, perform abnormality alarm; and if the voltage and current data represent no abnormality, determine the output voltage.

[0180] Based on the duodenum-based electric field ablation method according to the above embodiments, the present application further provides a duodenum-based electric field ablation device, as shown in Figure 12 Figure 12 ​A structural schematic diagram of a duodenum-based electric field ablation device provided in an embodiment of the present application is shown in FIG. 12. The duodenum-based electric field ablation device 12 includes a processor 1201 and a memory 1202. The memory 1202 is configured to store a computer program, and the processor 1201 is configured to call and run the computer program from the memory to perform the duodenum-based electric field ablation method as described in the above embodiment.

[0181] In an embodiment of the present application, the processor 1201 can be at least one of an Application Specific Integrated Circuit (ASIC), a Digital Signal Processor (DSP), a Digital Signal Processing Device (DSPD), a Programmable Logic Device (PLD), a Field Programmable Gate Array (FPGA), a Central Processing Unit (CPU), a controller, a microcontroller, or a microprocessor. It can be understood that, for different devices, the electronic device used to implement the functions of the processor can also be other devices, and the present application is not limited in this regard.

[0182] In addition, each functional module in the embodiment of the present application can be integrated in one processing unit, or each unit can exist physically independently, or two or more units can be integrated in one unit. The integrated unit can be realized in the form of hardware or in the form of a software functional module.

[0183] When the integrated unit is realized in the form of a software functional module and is not sold or used as an independent product, it can be stored in a computer readable storage medium. Based on this understanding, the technical solutions of the present application essentially or the part that contributes to the prior art, or the whole or part of the technical solutions can be embodied in the form of a software product. The computer software product is stored in a storage medium and includes a number of instructions for causing a computer device (which can be a personal computer, a server, or a network device, etc.) or a processor to perform all or part of the steps of the method of the present application. The aforementioned storage medium includes a variety of media that can store program codes, such as a U disk, a mobile hard disk, a Read Only Memory (ROM), a Random Access Memory (RAM), a magnetic disk or an optical disk.

[0184] It should be understood that every feature, structure, or characteristic described above that is mentioned in connection with an "embodiment" or "one embodiment" or "some embodiments" means that the feature, structure, or characteristic is included in at least one embodiment of the application. Therefore, appearances of the phrases "in one embodiment" or "in an embodiment" or "in some embodiments" in various places in the specification are not necessarily referring to the same embodiment of the application. Furthermore, the features, structures, or characteristics can be combined in any suitable manner in one or more embodiments. It should be understood that the sequence of the above-mentioned processes is not meant to imply a sequence of execution, and the execution sequence of the processes should be determined according to their functions and inherent logic, and should not constitute any limitation on the implementation process of the embodiments of the application. The above-mentioned sequence of the embodiments of the application is only for description, and does not represent the advantages or disadvantages of the embodiments. The above description of each embodiment tends to emphasize the differences between each embodiment, and the same or similar parts can be referred to each other, and for the sake of brevity, the description is not repeated herein.

[0185] The above-mentioned modules described as separate components can or can not be physically separate, and the components shown as modules can or can not be physical modules; they can be located in one place or distributed on multiple network units; and part or all of the modules can be selected according to actual needs to achieve the purpose of the embodiments of the present application.

[0186] In addition, each functional module in each embodiment of the application can be integrated in one processing unit, or each module can be a separate unit, or two or more modules can be integrated in one unit; the integrated module can be realized in the form of hardware or in the form of hardware plus software functional unit.

[0187] Those skilled in the art can understand that all or part of the steps of the above-mentioned method embodiments can be completed by program instruction related hardware, and the above-mentioned program can be stored in a computer readable storage medium, and the program executes the steps of the above-mentioned method embodiments when executed; and the above-mentioned storage medium includes mobile storage device, read only memory (Read Only Memory, ROM), magnetic disc or optical disc and various storage program codes.

[0188] The methods disclosed in the several method embodiments provided by the embodiments of the application can be combined in any manner without conflict to obtain new method embodiments.

[0189] The features disclosed in the several product embodiments provided by the embodiments of the application can be combined in any manner without conflict to obtain new product embodiments.

[0190] The features disclosed in the several method or device embodiments provided by the embodiments of the present application can be combined arbitrarily without conflict, to obtain new method embodiments or device embodiments.

[0191] The above merely describes the implementation manners of the embodiments of the present application, but the protection scope of the embodiments of the present application is not limited thereto, any person skilled in the art can easily think of changes or replacements within the technical range disclosed by the present application, which should be covered in the protection scope of the embodiments of the present application. Therefore, the protection scope of the embodiments of the present application should be subject to the protection scope of the claims.

Claims

1. An electric field ablation system based on the duodenum, characterized in that, include: Determine the unit and generate the unit, wherein, The determining unit is used to determine the narrow pulse parameters required for the target tissue when the target tissue corresponding to the target object is determined; wherein, the target tissue is the part of the duodenum of the target object that needs to be ablated by pulsed electric field; and to determine the status information of the main control system; The generation unit is used to detect the state information of the main control system, and when the state information of the main control system reaches a preset condition, generate a first pulse and a second pulse based on the narrow pulse parameters; wherein, the preset condition is that the state information reaches a preset state. The determining unit is further configured to perform phase-shifting control processing through an H-bridge circuit based on the first pulse and the second pulse to determine the narrow pulse corresponding to the narrow pulse parameter; and to perform electric field ablation on the target tissue through multiple electrodes based on the narrow pulse. The determining unit is further configured to: determine a first phase difference between pulse A and pulse B when the first pulse is pulse A and the second pulse is pulse B; based on the first phase difference, superimpose pulse A and pulse B using the H-bridge circuit to determine a high-voltage positive pulse; determine the high-voltage positive pulse as the narrow pulse corresponding to the narrow pulse parameter; determine a second phase difference between pulse C and pulse D when the first pulse is pulse C and the second pulse is pulse D; based on the second phase difference, perform phase-shift control processing on pulse C and pulse D using the H-bridge circuit to determine a high-voltage negative pulse; and... The high-voltage negative pulse is determined to be the narrow pulse corresponding to the narrow pulse parameter; when the first pulse is pulse A and pulse C, and the second pulse is pulse B and pulse D, the first phase difference between pulse A and pulse B, and the second phase difference between pulse C and pulse D are determined; based on the first phase difference, pulse A and pulse B are superimposed using the H-bridge circuit to determine the high-voltage positive pulse; based on the second phase difference, pulse C and pulse D are phase-shifted using the H-bridge circuit to determine the high-voltage negative pulse; the high-voltage positive pulse and the high-voltage negative pulse are determined to be the narrow pulse corresponding to the narrow pulse parameter.

2. The system according to claim 1, characterized in that, The duodenal-based electric field ablation system further includes: a configuration unit; wherein, The configuration unit is used to configure the channel combination output state, timing information and number of pulse outputs of the driving H-bridge circuit based on the narrow pulse parameters. The generation unit is further configured to generate the first pulse and the second pulse by driving the H-bridge circuit based on the channel combination output state, the timing information, and the number of pulse outputs.

3. The system according to claim 2, characterized in that, The generation unit is further configured to generate the first pulse and the second pulse when the channel combination output state is a first combination; wherein the first combination is channel A and channel B; the first pulse is pulse A; and the second pulse is pulse B; generate the first pulse and the second pulse when the channel combination output state is a second combination; wherein the second combination is channel C and channel D; the first pulse is pulse C; and the second pulse is pulse D; generate the first pulse and the second pulse when the channel combination output state is a third combination; wherein the third combination is channel A, channel B, channel C, and channel D; the first pulse is pulse A and pulse C; and the second pulse is pulse B and pulse D.

4. The system according to claim 1, characterized in that, The determining unit is further configured to initialize the main control system and the auxiliary control system respectively, determine the status information of the main control system and the auxiliary control system; perform status detection, configure high-voltage power supply output parameters and sample processing on the main control system to determine the output voltage; if the output voltage is greater than or equal to a preset voltage parameter, the status information corresponding to the main control system is sent to the auxiliary control system through the main-auxiliary data communication module; if the output voltage is less than the preset voltage parameter, the output voltage is updated through parameter adjustment until the updated output voltage is greater than or equal to the preset voltage parameter, and the status information corresponding to the main control system is sent to the auxiliary control system through the main-auxiliary data communication module; and the status information of the main control system is detected by the auxiliary control system.

5. The system according to claim 1, characterized in that, The duodenal-based electric field ablation system further includes: a sampling unit; wherein, The generation unit is also used to perform state detection on the main control system and configure the output parameters of the high-voltage power supply, and generate a PWM drive waveform; based on the PWM drive waveform, drive the high-voltage power supply to generate high-voltage data; The sampling unit is used to sample and process the high voltage data to obtain sampled data; The determining unit is further configured to perform smoothing filtering on the sampled data to determine voltage and current data; if the voltage and current data indicates an anomaly, an anomaly alarm is triggered; if the voltage and current data indicates no anomaly, the output voltage is determined.

6. An electric field ablation device based on the duodenum, characterized in that, include: Processor and memory, of which, The memory is used to store computer programs; The processor is configured to retrieve and run the computer program from the memory to perform the following steps: Given a target tissue corresponding to a target object, determine the narrow pulse parameters required for the target tissue; wherein, the target tissue is the part of the duodenum of the target object that needs to be ablated by pulsed electric field; determine the status information of the main control system; The status information of the main control system is detected, and when the status information of the main control system reaches a preset condition, a first pulse and a second pulse are generated based on the narrow pulse parameters; wherein, the preset condition is that the status information reaches a preset state; Based on the first pulse and the second pulse, phase-shifting control processing is performed through an H-bridge circuit to determine the narrow pulse corresponding to the narrow pulse parameter; based on the narrow pulse, electric field ablation of the target tissue is achieved through multiple electrodes; When the first pulse is pulse A and the second pulse is pulse B, a first phase difference between pulse A and pulse B is determined; based on the first phase difference, pulse A and pulse B are superimposed using the H-bridge circuit to determine a high-voltage positive pulse; the high-voltage positive pulse is then identified as the narrow pulse corresponding to the narrow pulse parameter; when the first pulse is pulse C and the second pulse is pulse D, a second phase difference between pulse C and pulse D is determined; based on the second phase difference, pulse C and pulse D are phase-shifted using the H-bridge circuit to determine a high-voltage negative pulse; the high-voltage negative pulse is then identified as the narrow pulse corresponding to the narrow pulse parameter. The pulse is determined to be the narrow pulse corresponding to the narrow pulse parameter; when the first pulse is pulse A and pulse C, and the second pulse is pulse B and pulse D, the first phase difference between pulse A and pulse B, and the second phase difference between pulse C and pulse D are determined; based on the first phase difference, pulse A and pulse B are superimposed using the H-bridge circuit to determine a high-voltage positive pulse; based on the second phase difference, pulse C and pulse D are phase-shifted using the H-bridge circuit to determine a high-voltage negative pulse; the high-voltage positive pulse and the high-voltage negative pulse are determined to be the narrow pulse corresponding to the narrow pulse parameter.

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