Lung-clearing, phlegm-eliminating and cough-relieving composition containing high Fruu-Asp pear essence as well as preparation method and application of lung-clearing, phlegm-eliminating and cough-relieving composition

Abstract

The invention relates to the technical field of phlegm eliminating and cough stopping, in particular to a lung clearing, phlegm eliminating and cough stopping composition containing high Fruu-Asp pear essence as well as a preparation method and application of the lung clearing, phlegm eliminating and cough stopping composition. The lung-clearing, phlegm-eliminating and cough-relieving composition containing the high Fruu-Asp pear essence is prepared from the following components in parts by weight: 5-50 parts of the high Fruu-Asp pear essence, 10-30 parts of white hyacinth beans and 25-50 parts of chrysanthemums, the prepared composition containing the high Fruu-Asp pear essence can synergistically improve the effects of clearing lung, relieving cough and reducing sputum, and meanwhile, the components are all medicinal and edible raw materials, so that the composition containing the high Fruu-Asp pear essence is free of toxic and side effects. And the use safety is improved.

Description

Technical Field

[0001] The present invention relates to the technical field of expectoration and cough relief, and in particular to a lung-clearing, expectoration and cough-relieving composition containing high-Fru-Asp pear extract, as well as a preparation method and application thereof. Background Art

[0002] Coughing is a protective mechanism of the respiratory tract, helping to clear irritants and prevent damage. Common types of coughs are exogenous coughs, which are mostly caused by the six external pathogens invading the lung system, with wind-cold, wind-heat, and wind-dryness coughs being the most common. The lungs prefer moisture and dislike dryness, so autumn dryness is most likely to harm the lungs. Mild cases can result in dry coughs with little sputum, while severe cases can result in blood in the sputum. Therefore, nourishing and moisturizing the lungs should be prioritized. The lungs are the organ that exchanges gases with the outside world. Pulmonary inflammation can easily expose an excessive number of cough receptors in the airways, creating favorable conditions for coughing. It can also make sputum thick and difficult to cough up, leading to frequent coughing. Treatment usually focuses on dispelling wind and heat, promoting lung function, and relieving coughs.

[0003] Currently, commonly used cough suppressants are mainly categorized as medications that reduce irritation to the pharyngeal cough receptors, antibiotics, anti-inflammatory drugs, and centrally acting antitussives. Syrups like pear paste offer significant advantages by reducing irritation to the pharyngeal cough receptors without side effects.

[0004] Pear paste is a traditional Chinese medicinal food, made by boiling the juice of pears or pears and other edible ingredients together. It has the functions of promoting salivation, removing phlegm, reducing internal heat, nourishing yin, and relieving cough.

[0005] Amadori compounds are relatively stable products in the early stages of the Maillard reaction. Fru-Asp is one of these compounds and a characteristic Amadori compound in pear paste. A paper from Jiangnan University, "Detection, Regulation, and Functional Research of Amadori Compounds in Pear Paste," specifically explored Fru-Asp, a characteristic Amadori compound in pear paste, and further explored its functional properties, including its antioxidant properties, ACE inhibition, cough suppressant properties, and lung inflammation relief.

[0006] Chinese patent CN115590911A discloses a pear paste with a high Fru-Asp content for cough and expectoration, as well as its preparation and ingredient detection methods. The invention's preparation method comprises the following steps: Step 1: selecting, washing, crushing, squeezing, and filtering to obtain pear juice; Step 2: concentrating to a solids content of 55-65%; Step 3: maintaining the liquid in a closed system at a temperature of 80-90°C for 3-5 hours; Step 4: rapidly evaporating the water to a total solids content of 70-75%; and Step 5: weighing, filling, sealing, and packaging to obtain the pear paste. This invention's preparation process increases the Fru-Asp content in the pear paste by over 150%, reduces the 5-HMF content to only 4.37% of the average value of conventional pear paste products, and demonstrates significant cough and expectoration efficacy.

[0007] Although much research has been conducted on the optimization of the preparation process of pear paste, the lung-clearing, phlegm-reducing and cough-relieving effects of a single ingredient in pear paste are limited. Therefore, based on pear paste, more products for clearing the lungs, resolving phlegm and relieving coughs still need to be studied to achieve better lung-clearing, phlegm-reducing and cough-relieving effects while being natural and healthy. Summary of the Invention

[0008] The present invention provides a lung-clearing, phlegm-relieving, and cough-relieving composition containing high-Fru-Asp pear extract, as well as its preparation method and application. By utilizing the synergistic effect of natural raw materials, white lentils and chrysanthemums were selected for combination with high-Fru-Asp pear extract. The composition was found to synergistically enhance the lung-clearing, cough-relieving, and phlegm-relieving effects while also possessing significant anti-inflammatory activity, thereby enhancing the therapeutic effects of pear paste products. Furthermore, the ingredients are all medicinal and edible, enhancing safety.

[0009] In order to achieve the above-mentioned purpose of the invention, the technical solution of the present invention is as follows: In one aspect, the present invention provides a lung-clearing, phlegm-reducing and cough-relieving composition containing high-Fru-Asp pear extract, which is prepared from the following ingredients in parts by weight: 5-50 parts of high-Fru-Asp pear extract, 10-30 parts of white lentils and 25-50 parts of chrysanthemum.

[0010] Chrysanthemum has the effect of clearing heat and detoxifying, and white lentil is a good adjuvant for cough and phlegm products. The two are combined with high Fru-Asp pear extract to prepare a composition, which significantly improves the effects of clearing the lungs, resolving phlegm and relieving cough, achieving good synergistic effects.

[0011] In the present invention, high Fru-Asp pear extract means a pear paste with a Fru-Asp mass content of ≥1.0%.

[0012] Fru-Asp is one of the Amadori compounds and is also the characteristic Amadori compound in pear paste. You can refer to the description of Fru-Asp in literature such as the paper "Detection, Regulation and Functional Research of Amadori Compounds in Pear Paste" from Jiangnan University.

[0013] Preferably, the Fru-Asp mass content in the high Fru-Asp pear extract is ≥1.2%.

[0014] Preferably, the lung-clearing, phlegm-reducing and cough-relieving composition containing high-Fru-Asp pear extract is made from the following ingredients in parts by weight: 10-40 parts of high-Fru-Asp pear extract, 12-20 parts of white lentils and 30-45 parts of chrysanthemum.

[0015] Further preferably, the lung-clearing, phlegm-reducing and cough-relieving composition containing high-Fru-Asp pear extract is made from the following ingredients in parts by weight: 20 parts of high-Fru-Asp pear extract, 15 parts of white lentils and 40 parts of chrysanthemum.

[0016] In another aspect, the present invention provides a method for preparing the lung-clearing, phlegm-reducing and cough-relieving composition containing the high-Fru-Asp pear extract, comprising the following steps: (1) Crush the formulated amount of chrysanthemum and white lentil, add water to boil and extract, filter to obtain a filtrate; (2) The filtrate obtained in step (1) was placed at -5°C to 5°C for 2 h to 15 h, filtered, and the supernatant was collected and concentrated to a relative density of 1.15 to 1.2 to obtain a concentrated solution; (3) The concentrated solution obtained in step (2) is mixed with the formulated amount of high Fru-Asp pear extract to obtain the product.

[0017] Preferably, in step (1), the decoction and extraction are specifically as follows: decoction and extraction are performed 1-3 times, each time adding 10-20 times the weight of water and decocting for 0.5h-2h; further preferably, decoction and extraction are performed 2 times, each time adding 15 times the weight of water and decocting for 1h.

[0018] In step (1), the filtration may be a conventional filtration method in the art, the purpose of which is to achieve the effect of solid-liquid separation, including but not limited to normal pressure filtration, reduced pressure filtration, etc.

[0019] In step (2), the concentration may be a conventional concentration method in the art, including but not limited to evaporation concentration, membrane separation concentration, reduced pressure concentration, etc.

[0020] Preferably, step (2) is specifically as follows: placing the filtrate obtained in step (1) at 0°C for 10 hours, filtering, taking the supernatant, and concentrating under reduced pressure to a relative density of 1.15-1.2 to obtain a concentrated solution.

[0021] For the technical solution of the present invention, placing the extract under appropriate low temperature conditions to precipitate unnecessary components and optimize the composition of the extract is a necessary preparation step. The best condition for achieving precipitation is: placing the extract at 0°C for 10 hours.

[0022] As a most preferred example of the present invention, the following steps are included: (1) Crush the formulated amount of chrysanthemum and white lentil, add water and boil and extract twice, adding 15 times the weight of water each time and boiling and extracting for 1 hour, filter and combine the filtrates; (2) The filtrate obtained in step (1) was placed at 0°C for 10 hours, filtered, and the supernatant was collected and concentrated under reduced pressure to a relative density of 1.15-1.2 to obtain a concentrated solution; (3) The concentrated solution obtained in step (2) is mixed with the formulated amount of high Fru-Asp pear extract, and the mixture is stirred thoroughly to obtain the product.

[0023] Preferably, the preparation method of the lung-clearing, phlegm-reducing and cough-relieving composition containing high-Fru-Asp pear extract may further comprise the step of freeze-drying the product obtained in step (3) to prepare a powder preparation, depending on the preparation form required.

[0024] Preferably, the lung-clearing, phlegm-reducing and cough-relieving composition containing high-Fru-Asp pear extract can also be made of suitable raw materials and auxiliary materials according to the needs of product type or functional direction. Examples of the raw materials and auxiliary materials include stabilizers, natural pigments, acidity regulators, sweetness regulators, thickeners, emulsifiers and natural antioxidants.

[0025] Among them, examples of the stabilizer include pectin, mannitol, xanthan gum, etc.; examples of natural pigments include carmine, β-carotene, gardenia powder, etc.; examples of acidity regulators include DL-malic acid, citric acid, etc.; examples of sweetness regulators include maltitol, sorbitol, erythritol, steviol glycosides, mogrosides, etc.; examples of thickeners include soybean polysaccharides, sodium caseinate, etc.; examples of emulsifiers include phospholipids, glycerol, etc.; examples of natural antioxidants include ascorbic acid, tea polyphenols, vitamin E, etc.

[0026] Preferably, the lung-clearing, phlegm-reducing and cough-relieving composition containing high-Fru-Asp pear extract can be prepared into the following dosage forms as needed: candy, beverage, soft capsule, paste, tea bag, jelly, protein bar, nut bar, etc.

[0027] In another aspect, the present invention provides use of the lung-clearing, phlegm-resolving and cough-relieving composition containing high-Fru-Asp pear extract in the preparation of a lung-clearing and phlegm-resolving product.

[0028] Finally, the present invention provides the use of the lung-clearing, phlegm-resolving and cough-relieving composition containing high-Fru-Asp pear extract in the preparation of anti-inflammatory and cough-relieving products.

[0029] In the present invention, the term "prevention and treatment" includes prevention and / or treatment, and is a preventive and therapeutic measure for cough and sputum. It includes methods for preventing the occurrence of cough, the purpose of which is to prevent, slow down (reduce) undesirable physiological changes or pathological changes in the subject. Beneficial or desired clinical outcomes include, but are not limited to, avoiding the occurrence of cough and sputum, alleviating the symptoms of cough and sputum, reducing the severity of cough and sputum, stabilizing the cough and sputum state (no worsening), delaying or slowing the progression of cough, improving or alleviating the cough and sputum state, and alleviating.

[0030] Those in need of treatment include those already with the condition or disease as well as those prone to have the condition or disease or those in which the condition or disease is to be prevented.

[0031] In the present invention, the objects of prevention and treatment are humans or mammals, and the mammals include bovines, equines, ovines, porcines, canines, felines, rodents, and primates. The rodents are mice and / or rats.

[0032] The beneficial effects of the present invention are: (1) By combining white lentil, chrysanthemum and high Fru-Asp pear extract in a reasonable proportion, a synergistic effect is shown in the treatment of clearing the lungs and resolving phlegm, and reducing inflammation and relieving cough, which significantly improves the therapeutic activity.

[0033] (2) The raw materials of the present invention are all natural ingredients that are both medicinal and edible, and are highly safe to use.

[0034] (3) The present invention uses a method of combining water extraction and low-temperature precipitation to extract impurities from white lentils and chrysanthemums to obtain a concentrated solution, thereby obtaining a synergistic composition. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] Figure 1 This is the detection spectrum of the high Fru-Asp pear extract used in the present invention.

[0036] Figure 2 This is a graph showing the test results of phenol red excretion in the control group, positive drug group, and example group; In the figure, Compared with the control group, p < 0.05, Represents p < 0.01 compared with the control group.

[0037] Figure 3 The graph shows the phenol red excretion test results of the Example 1 group and the comparative example group; In the figure, Compared with the Example 1 group, p < 0.05, Compared with the Example 1 group, p < 0.01.

[0038] Figure 4 The swelling rate test results of the control group, positive drug group, example group and comparative example group are shown in FIG. In the figure, Compared with the control group, p < 0.05, represents p < 0.01 compared with the control group; # represents p<0.05 compared with the Example 1 group, and ## represents p<0.01 compared with the Example 1 group. DETAILED DESCRIPTION

[0039] The following non-limiting examples are provided to enable those skilled in the art to more fully understand the present invention, but are not intended to limit the present invention in any way. The following are merely illustrative of the scope of the present invention, and those skilled in the art may make various changes and modifications to the present invention based on the disclosed content, which should also fall within the scope of the present invention.

[0040] The present invention will be further described below by way of specific examples. The various chemical reagents used in the examples of the present invention were obtained through conventional commercial channels unless otherwise specified. Unless otherwise specified, the contents described below are all by weight. Unless otherwise specified, it is understood that the experiments were conducted at room temperature.

[0041] In the following examples, the relative density of the concentrated solution was measured at 60°C.

[0042] The high Fru-Asp pear extract is a pear paste prepared according to Example 2 of Chinese Patent CN115590911A. After testing, the Fru-Asp content is 1.2%. The mass spectrometry conditions for the test are shown in Table 1. The test spectrum is shown in Figure 1 shown.

[0043] Table 1

[0044] Table 2 shows the results of animal experiments (using the same testing methods as those described in the following examples) showing the cough-relieving, expectorant, and anti-inflammatory effects of the High Fru-Asp Pear Extract.

[0045] Table 2

[0046] Note: In the table, Represents p < 0.01 compared with the control group.

[0047] The present invention is based on the high Fru-Asp pear extract prepared in Chinese patent CN115590911A. With the purpose of improving the cough and phlegm-relieving effect, reducing the dosage, and achieving the anti-inflammatory effect, a compound product with better activity and more comprehensiveness is obtained through the screening and improvement of the formulation and process.

[0048] Example 1 According to weight, the raw material formula is: 20 parts of high Fru-Asp pear extract, 15 parts of white lentils and 40 parts of chrysanthemum.

[0049] Preparation process: (1) Crush the formulated amount of chrysanthemum and white lentil, add water and boil and extract twice, adding 15 times the weight of water each time and boiling and extracting for 1 hour, filter and combine the filtrates; (2) The filtrate obtained in step (1) was placed at 0°C for 10 hours, filtered, and the supernatant was collected and concentrated under reduced pressure to a relative density of 1.2 to obtain a concentrated solution; (3) The concentrated solution obtained in step (2) is mixed with the formulated amount of high Fru-Asp pear extract, and the mixture is stirred thoroughly to obtain the product.

[0050] Example 2 The difference from Example 1 is that, in parts by weight, the raw material formula of Example 2 is: High Fru-Asp pear extract 10 parts, white lentil 20 parts and chrysanthemum 45 parts.

[0051] The preparation process is the same as that of Example 1.

[0052] Example 3 The difference from Example 1 is that, in parts by weight, the raw material formula of Example 3 is: High Fru-Asp pear extract 40 parts, white lentil 12 parts and chrysanthemum 30 parts.

[0053] The preparation process is the same as that of Example 1.

[0054] Example 4 The difference from Example 1 is that, in parts by weight, the raw material formula of Example 4 is: 5 parts of High Fru-Asp Pear Extract, 30 parts of White Lentils and 50 parts of Chrysanthemum.

[0055] The preparation process is the same as that of Example 1.

[0056] Example 5 The difference from Example 1 is that, in parts by weight, the raw material formula of Example 5 is: High Fru-Asp pear extract 50 parts, white lentil 10 parts and chrysanthemum 25 parts.

[0057] The preparation process is the same as that of Example 1.

[0058] Example 6 The difference from Example 1 is that step (2) of Example 6 is as follows: the filtrate obtained in step (1) is placed at -5°C for 2 hours, taken out and properly placed at room temperature, filtered, the supernatant is taken, and concentrated under reduced pressure to a relative density of 1.2 to obtain a concentrated solution.

[0059] Example 7 Different from Example 1, step (2) of Example 7 is as follows: the filtrate obtained in step (1) is placed at 5°C for 15 hours, filtered, the supernatant is taken, and concentrated under reduced pressure to a relative density of 1.2 to obtain a concentrated solution.

[0060] Comparative Example 1 The difference from Example 1 is that, in parts by weight, the raw material formula of Comparative Example 1 is: 20 parts of High Fru-Asp Pear Extract and 15 parts of White Lentils.

[0061] The preparation process is the same as that of Example 1.

[0062] Comparative Example 2 The difference from Example 1 is that, in parts by weight, the raw material formula of Comparative Example 2 is: 20 parts of high Fru-Asp pear extract and 40 parts of chrysanthemum.

[0063] The preparation process is the same as that of Example 1.

[0064] Comparative Example 3 The difference from Example 1 is that, in parts by weight, the raw material formula of Comparative Example 3 is: 20 parts of High Fru-Asp Pear Extract, 15 parts of White Lentils and 40 parts of Tremella.

[0065] The preparation process is the same as that of Example 1.

[0066] Comparative Example 4 The difference from Example 1 is that, in parts by weight, the raw material formula of Comparative Example 4 is: High Fru-Asp pear extract 20 parts, monk fruit 15 parts and orange peel 40 parts.

[0067] The preparation process is the same as that of Example 1.

[0068] Comparative Example 5 The raw material formula is the same as that in Example 1, and the preparation process is as follows: (1) Crush the formulated amount of chrysanthemum and white lentil, add water and boil and extract twice, adding 15 times the weight of water each time and boiling and extracting for 1 hour, filter and combine the filtrates; (2) Filter the filtrate obtained in step (1), take the supernatant, and concentrate under reduced pressure to a relative density of 1.2 to obtain a concentrated solution; (3) The concentrated solution obtained in step (2) is mixed with the formulated amount of high Fru-Asp pear extract, and the mixture is stirred thoroughly to obtain the product.

[0069] Results test: 1. Cough suppression effect test Experimental animals: Healthy Kunming mice (18g-22g), half male and half female.

[0070] Preliminary screening: Mice were placed in an inverted 500mL glass beaker and exposed to 0.2mL of 25% concentrated ammonia for 45 seconds using the cotton ball method. Mice were considered qualified if their cough latency was less than 1 minute and they coughed >3 times within 1 minute. Otherwise, mice were excluded. Cough criteria included abdominal muscle contraction, mouth opening, and sometimes a coughing sound. Qualified mice were randomly divided into groups of 10 per group and dosed every other day.

[0071] Experimental groups and drug administration: Positive drug group: Oral administration of dextromethorphan hydrobromide, once a day, dose of 30 mg / kg, oral volume of 20 mL / kg, for 5 consecutive days; Experimental group: Administered high-Fru-Asp pear extract, the products prepared in Examples 1 to 7, and Comparative Examples 1 to 5, once daily at a dose of 2 g / kg and an oral gavage volume of 20 mL / kg for 5 consecutive days; Control group: gavage with equal volume of normal saline.

[0072] Experimental methods: One hour after the last dose, mice were placed in an inverted 500-mL glass beaker and exposed to 0.2 mL of 25% concentrated ammonia for 45 seconds using the cotton ball method. The cough latency (time from the onset of stimulation to the first cough) was recorded in seconds, and the number of coughs within 2 minutes was recorded in times.

[0073] The results are shown in Table 3.

[0074] Table 3

[0075] Note: In the table, Compared with the control group, p < 0.05, Represents p < 0.01 compared with the control group.

[0076] The results showed that compared with the control group, the products prepared in Examples 1-7 of the present invention were able to significantly prolong the cough latency period and reduce the number of coughs. Compared with the group treated with high Fru-Asp pear extract, the cough suppression level was also improved to a certain extent. Comparative Examples 1-7 also showed significant differences compared with the control group, but at the specific data level, there were still significant differences compared with Example 1.

[0077] 2. Expectorant effect test Experimental animals: healthy Kunming mice (18g-22g), half male and half female, fasted but not watered for 16h before the experiment.

[0078] Experimental groups and drug administration: Positive drug group: Oral administration of ambroxol hydrochloride solution (China Resources Sanjiu Pharmaceutical, national medicine standard H20103009) once a day, dosage 6.15mL / kg, oral volume 20mL / kg, for 5 consecutive days; Experimental group: Administered high-Fru-Asp pear extract, the products prepared in Examples 1 to 7, and Comparative Examples 1 to 5, once daily at a dose of 2 g / kg and an oral gavage volume of 20 mL / kg for 5 consecutive days; Control group: gavage with equal volume of normal saline.

[0079] Experimental methods: One hour after the last dose, 0.5 mL of 0.5% phenol red solution was injected intraperitoneally. The mice were killed 30 minutes later, and the trachea between the thyroid cartilage and the main bronchus was separated and placed in a test tube. 1 mL of 5% NaHCO3 saline solution was added and ultrasonicated for 10 minutes. The absorbance OD value at 546 nm was measured using a multifunctional microplate reader.

[0080] Phenol red in 5% NaHCO3 saline solution with concentrations of 10μg / mL, 5μg / mL, 2.5μg / mL, 1μg / mL, 0.5μg / mL, 0.25μg / mL, and 0.1μg / mL were prepared respectively, and their absorbance OD values ​​at 546nm were measured. A phenol red standard curve was drawn, and the phenol red excretion amount (μg / mL) and the excretion increase rate (%) were calculated.

[0081] The excretion increase rate = (phenol red excretion in the experimental group - phenol red excretion in the control group) / phenol red excretion in the control group × 100%.

[0082] The results are as follows Figure 2 、 Figure 3 shown.

[0083] Depend on Figure 2The results show that the product prepared in this example significantly increased phenol red excretion, demonstrating that the composition can better promote pharyngeal and bronchial mucus secretion and achieve a good expectorant effect. Compared with the group treated with high-Fru-Asp pear extract (Table 2), the expectorant effect was significantly improved, overcoming the limited therapeutic activity of high-Fru-Asp pear extract.

[0084] Figure 3 The results show that the results of Comparative Examples 1 to 5 show significant differences in phenol red excretion compared to Example 1, and correspondingly, the excretion increase rate is very different. Among them, the formulas in Comparative Examples 1 to 4 were screened, and the results showed that the combination of high Fru-Asp pear extract, white lentils and chrysanthemums can further improve the expectorant effect of Fru-Asp pear extract and reduce the dosage compared to other conventional combinations. The preparation process of Comparative Example 5 does not perform a low-temperature treatment step. Compared with Example 1, the results show that appropriate low-temperature treatment can significantly improve the impurity removal effect, optimize the composition of the composition, and thus significantly improve the expectorant activity of the obtained product.

[0085] 3. Anti-inflammatory effect detection Experimental animals: Healthy Kunming mice (18g-22g), half male and half female.

[0086] Experimental groups and drug administration: Positive drug group: oral administration of prednisone 5 mg / kg, once a day, oral volume 20 mL / kg, for 3 consecutive days; Experimental group: The products prepared in Examples 1 to 7 and Comparative Examples 1 to 5 were administered once a day at a dose of 2 g / kg and an oral gavage volume of 20 mL / kg for 3 consecutive days. Control group: gavage with equal volume of normal saline.

[0087] Experimental methods: One hour after the last administration, 0.05 mL of xylene was applied to the inner and outer sides of the right ear of the experimental mice to induce inflammation. One hour later, the mice were killed by cervical dislocation, and the left and right ear pieces were taken from the same part using an 8 mm punch, weighed, and the swelling rate was calculated.

[0088] Swelling rate = (right ear weight - left ear weight) / left ear weight × 100%.

[0089] The results are as follows Figure 4 shown.

[0090] Figure 4The results showed that the combination of high-Fru-Asp pear extract, white lentils, and chrysanthemum simultaneously achieved excellent anti-inflammatory activity. The results of Comparative Examples 1-4 showed that the combination of high-Fru-Asp pear extract, white lentils, and chrysanthemum achieved even better anti-inflammatory activity. Specifically, the anti-inflammatory activity of Example 1 and the comparative example showed a significant difference. The comparison of Comparative Example 5 with Example 1 showed that appropriate low-temperature treatment also enhanced the anti-inflammatory activity of the resulting product.

[0091] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A lung-clearing, phlegm-reducing and cough-relieving composition containing high-Fru-Asp pear extract, characterized in that: The invention is prepared from the following ingredients in parts by weight: 5-50 parts of high Fru-Asp pear extract, 10-30 parts of white lentils and 25-50 parts of chrysanthemum; The high Fru-Asp pear extract is a pear paste with a Fru-Asp mass content of ≥1.0%.

2. The lung-clearing, phlegm-resolving and cough-relieving composition containing high-Fru-Asp pear extract according to claim 1, characterized in that: The high-Fru-Asp pear extract has a Fru-Asp content of ≥1.2%.

3. The lung-clearing, phlegm-resolving and cough-relieving composition containing high-Fru-Asp pear extract according to claim 2, characterized in that: The invention is prepared from the following ingredients by weight: 10-40 parts of high-Fru-Asp pear extract, 12-20 parts of white lentils and 30-45 parts of chrysanthemum.

4. The lung-clearing, phlegm-resolving and cough-relieving composition containing high-Fru-Asp pear extract according to claim 3, characterized in that: The product is made from the following ingredients by weight: 20 parts of high Fru-Asp pear extract, 15 parts of white lentils and 40 parts of chrysanthemum.

5. A method for preparing the lung-clearing, phlegm-reducing and cough-relieving composition containing high-Fru-Asp pear extract according to any one of claims 1 to 4, characterized in that: The following steps are involved: (1) Crush the formulated amount of chrysanthemum and white lentil, add water to boil and extract, and filter to obtain the filtrate; (2) The filtrate obtained in step (1) was placed at -5°C to 5°C for 2-15 hours, filtered, and the supernatant was collected and concentrated to a relative density of 1.15-1.2 to obtain a concentrated solution; (3) The concentrated solution obtained in step (2) is mixed with the formulated amount of high Fru-Asp pear extract to obtain the product.

6. The preparation method according to claim 5, characterized in that In step (1), the decoction and extraction are specifically as follows: decoction and extraction are performed 1-3 times, each time adding 10-20 times the weight of water and decocting for 0.5-2 hours.

7. The preparation method according to claim 5, characterized in that Step (2) is specifically as follows: placing the filtrate obtained in step (1) at 0°C for 10 hours, filtering, taking the supernatant, and concentrating under reduced pressure to a relative density of 1.15-1.2 to obtain a concentrated solution.

8. The preparation method according to claim 5, characterized in that The following steps are involved: (1) Crush the formulated amount of chrysanthemum and white lentil, add water and boil and extract twice, adding 15 times the weight of water each time and boiling and extracting for 1 hour, filter and combine the filtrates; (2) The filtrate obtained in step (1) was placed at 0°C for 10 hours, filtered, and the supernatant was collected and concentrated under reduced pressure to a relative density of 1.2 to obtain a concentrated solution; (3) The concentrated solution obtained in step (2) is mixed with the formulated amount of high Fru-Asp pear extract, and the mixture is stirred thoroughly to obtain the product.

9. The preparation method according to claim 5, characterized in that The method further comprises the step of freeze-drying the product obtained in step (3) to prepare a powder preparation.

10. Use of the lung-clearing, phlegm-reducing and cough-relieving composition containing high-Fru-Asp pear extract according to any one of claims 1 to 4 in the preparation of a lung-clearing and phlegm-reducing product.

11. Use of the lung-clearing, phlegm-resolving and cough-relieving composition containing high-Fru-Asp pear extract according to any one of claims 1 to 4 in the preparation of anti-inflammatory and cough-relieving products.

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