Dense polyester artificial blood vessel

Abstract

The present application relates to a kind of dense polyester artificial blood vessel, it is woven into tubular fabric by polyester fiber, then spiral thread is processed in tubular fabric inside and outside;Its characteristics are that the micropore of the tubular fabric is less than 10um.The woven micropore is controlled at <10um, ensure the whole blood vessel water permeability, i.e.not a lot of water permeability, cell can grow into again.The artificial blood vessel of the present application can be well controlled water permeability and have good biocompatibility, and using single raw material (polyester fiber), therefore, it is not necessary to increase coating again.Greatly reduce the risk brought by coating, i.e., the risk of animal source and other chemical additives toxicity risk, and the risk of thrombosis caused by coating material shedding in long-term implantation process.

Description

Technical Field

[0001] This invention relates to the field of textile biomaterials technology, and in particular to a dense polyester artificial blood vessel. Background Technology

[0002] Polyester braided artificial blood vessels were the earliest vascular material used, and due to their high patency rate, they have long been successfully used for large blood vessel replacement. However, the inside of polyester braided artificial blood vessels needs to be coated with a protein or gelatin coating to prevent blood penetration in a short period of time. At the same time, the rough inner surface of polyester blood vessels can easily activate the cascade reaction of blood coagulation, leading to the reformation of thrombi.

[0003] Therefore, existing polyester artificial blood vessels require pre-coagulation or collagen / gelatin coatings to control leakage rates. However, their drawback is:

[0004] (1) It can only prevent blood penetration for a short period of time.

[0005] (2) Risks of animal origin in the coating and toxicity risks of other chemical additives.

[0006] (3) The risk of thrombosis caused by the detachment of coating material during long-term implantation is also extremely high. Summary of the Invention

[0007] The purpose of this invention is to provide a dense polyester artificial blood vessel, which mainly solves the problems existing in the prior art. It is more conducive to long-term implantation for patients and greatly reduces various risks associated with the coating.

[0008] To achieve the above-mentioned objectives, the technical solution of the present invention is as follows:

[0009] A dense polyester artificial blood vessel is made by weaving polyester fibers into a tubular fabric and then processing spiral patterns on the inside and outside of the tubular fabric; characterized in that the micropores of the tubular fabric are less than 10 μm.

[0010] The dense polyester artificial blood vessel is characterized by:

[0011] When the diameter of the tubular fabric is ≤14mm, the weave spacing is 1±0.2mm and the weave height is 0.5±0.2mm.

[0012] When the diameter of the tubular fabric is greater than 14 mm, the weave spacing is 2 ± 0.2 mm and the weave height is 1 ± 0.2 mm.

[0013] The dense polyester artificial blood vessel is characterized in that: the polyester fiber uses polyester fiber with a fineness of 15D to 300D, and its microfilament part is 30F to 400F, that is, one polyester fiber is formed by the combination of 30 to 400 monofilament fibers.

[0014] The aforementioned dense polyester artificial blood vessel is characterized by the following method for forming a tubular fabric using polyester fiber weaving:

[0015] Polyester fibers are twisted to form S-twist and Z-twist. The two fibers twisted in different directions are arranged side by side to form a cohesive structure, namely, the A combination.

[0016] Several A combinations are processed side-by-side and closely onto the warping head using a warping machine, which is called B combination;

[0017] A combination A is wound onto a small shaft using a slitting device, which is combination C;

[0018] Set up combination B as the warp yarn head on the loom frame, and use a tension between 2g and 1200g to make the tension of combination A in combination B consistent, so as to facilitate stable weaving; set up combination C on the weft yarn head for weft yarn weaving;

[0019] Tubular fabrics are formed by weaving through combinations B and C.

[0020] The dense polyester artificial blood vessel is characterized in that: the tubular fabric is woven by machine, with a warp density > 220 threads / cm and a weft density > 120 threads / cm.

[0021] The dense polyester artificial blood vessel is characterized in that the weave structure of the tubular fabric is satin, plain weave, modified satin, or modified plain weave.

[0022] The dense polyester artificial blood vessel is characterized by the following method for processing the spiral pattern on the inside and outside of the tubular fabric:

[0023] The tubular fabric is inserted into a steel pipe with the same inner diameter. The two ends of the steel pipe are nested on the clamps of the texturing machine. The parameters of the texturing machine are set, and the texturing and winding operation begins.

[0024] The dense polyester artificial blood vessel is characterized by the following method for processing the spiral pattern on the inside and outside of the tubular fabric:

[0025] A. A first textured line is wound around the outside of a metal tube in a spiral pattern from the first end to the second end in the axial direction.

[0026] B. A tubular fabric is placed over a metal tube that has been wrapped with the first textured line;

[0027] C. Then, a second patterning line is wound around the metal tube that has been covered with tubular fabric in an axial direction from the first end to the second end in a spiral pattern, and the second patterning line is located between the loops of adjacent second patterning lines when it is wound.

[0028] D. Remove the second textured line and remove the tubular fabric from the metal tube to form a dense polyester artificial blood vessel with internal and external spiral textures.

[0029] The dense polyester artificial blood vessel is characterized by the following method for processing the spiral pattern on the inside and outside of the tubular fabric:

[0030] a. Take a metal tube with a threaded protrusion extending axially from the first end to the second end.

[0031] b. Cover the metal tube with a tubular fabric;

[0032] c. Then, a spiral pattern is wound around the metal tube that has been fitted with tubular fabric in the axial direction from the first end to the second end, and the spiral pattern is located between the loops of the adjacent spiral protrusions when the spiral pattern is wound.

[0033] d. Remove the textured lines and remove the tubular fabric from the metal tube to form a dense polyester artificial blood vessel with internal and external spiral patterns.

[0034] In view of the above technical features, compared with the prior art, the present invention has the following advantages:

[0035] 1. The artificial blood vessel of the present invention adopts a special braided structure, so that the micropores of the braid are controlled to <10um, which ensures that the water permeability of the entire blood vessel is not excessive, while allowing cells to grow in.

[0036] 2. Because the artificial blood vessel of the present invention can effectively control the permeability and has excellent biocompatibility, and uses a single raw material (polyester fiber), there is no need to add a coating. This greatly reduces the various risks associated with coatings, namely, the risks of animal origin and the toxicity risks of other chemical additives, as well as the risk of thrombosis caused by the detachment of coating materials during long-term implantation.

[0037] 3. The spiral patterns on the inner and outer surfaces of the artificial blood vessel in this invention enable the artificial blood vessel to have stretching and resilience functions. Attached Figure Description

[0038] Figure 1 This is a schematic diagram of the structure of the dense polyester artificial blood vessel of the present invention;

[0039] Figure 2 This is a schematic diagram of the structure of combination A in this invention;

[0040] Figure 3 This is a schematic diagram of the S-twist and Z-twist in combination A;

[0041] Figure 4 This is a schematic diagram of the structure of combination B in this invention;

[0042] Figure 5 This is a schematic diagram of the C combination in this invention;

[0043] Figure 6 This is the imaging of the densely woven structure of the polyester artificial blood vessel of the present invention under a 3D microscope.

[0044] Figure 7 This is the woven structure of existing polyester artificial blood vessels as visualized under a 3D microscope.

[0045] Figure 8 This is a schematic diagram of the operating state of the texturing device of the present invention. Figure 1 .

[0046] Figure 9 This is a schematic diagram of the operating state of the texturing device of the present invention. Figure 2 . Detailed Implementation

[0047] The present invention will be further described below with reference to specific embodiments. It should be understood that these embodiments are for illustrative purposes only and are not intended to limit the scope of the invention. Furthermore, it should be understood that after reading the teachings of this invention, those skilled in the art can make various alterations or modifications to the invention, and these equivalent forms also fall within the scope defined by the appended claims.

[0048] Please see Figure 1 This invention discloses a dense polyester artificial blood vessel, which is made by weaving polyester fibers into a tubular fabric and then processing spiral patterns on the inside and outside of the tubular fabric; the characteristic is that the micropores of the tubular fabric are less than 10 μm.

[0049] Please see Figure 6 The image shows the woven structure of the product, a dense tubular fabric (artificial blood vessel), under a microscope. The light-transmitting points are tightly surrounded by the fabric fibers, and at a water pressure of 16 kPa, the density is less than 5 ml / cm². 2 The water permeability requirements are now consistent with those of coated blood vessels. Because the micropores of the tubular fabric are less than 10µm, the light-transmitting gaps are significantly reduced, and the spacing between pores and the length and width of the strands are also significantly decreased. This causes the fibers in the blood vessel to be compressed more tightly within the same space, ultimately forming extremely dense gaps between the fibers. Under the surface tension of water, this prevents water pressure from penetrating the fabric, effectively reducing the water permeability to an acceptable range.

[0050] Please see again Figure 7 The figure shows the same as Figure 6 Under a microscope, the woven structure of existing products of the same specification, namely ordinary tubular fabrics (artificial blood vessels), shows that the fabric fibers cannot completely lock the micropores at the light-transmitting points. At a water pressure of 16 kPa, this is far greater than 5 ml / cm². 2Therefore, artificial blood vessels need to be coated with a protein or gelatin layer to prevent blood from seeping in for a short period of time.

[0051] The dense polyester artificial blood vessel of the present invention has a texture spacing of 1±0.2mm and a texture height of 0.5±0.2mm when the diameter of the tubular fabric is ≤14mm; and a texture spacing of 2±0.2mm and a texture height of 1±0.2mm when the diameter of the tubular fabric is >14mm.

[0052] In this invention, the polyester fiber uses polyester fiber with a fineness of 15D to 300D, and its microfilament portion is 30F to 400F, that is, one polyester fiber is formed by the combination of 30 to 400 monofilament fibers.

[0053] like Figure 2-5 As shown, the method for forming tubular fabrics using polyester fiber weaving is as follows:

[0054] Polyester fibers are twisted to form S-twist and Z-twist. These two fibers, twisted in different directions, are arranged side-by-side to form a cohesive structure, namely, combination A2, as shown below. Figure 2 , 3 Among them, both S-twist and Z-twist should maintain a T / M of 300-600T / M.

[0055] Several A combinations 2 are processed side-by-side and closely onto the warping head 3 using warping equipment 1, i.e., B combinations, such as... Figure 4 .

[0056] Combination A 2 is wound onto small shaft 4 using a slitting device, i.e., combination C, as shown. Figure 5 .

[0057] The B group is placed on the loom yarn frame as the warp yarn head, and the tension of the A group in the B group is kept consistent with the tension between 2g and 1200g to facilitate stable weaving; the C group is set on the weft yarn head for weft yarn weaving.

[0058] Tubular fabrics are formed by weaving through combinations B and C.

[0059] The tubular fabric is woven by machine, with a warp density of >220 threads / cm and a weft density of >120 threads / cm.

[0060] The tubular fabric is woven in a satin, plain, or modified satin or modified plain weave pattern.

[0061] In this invention, the spiral patterns processed on the inner and outer surfaces of the artificial blood vessel enable it to have stretching and resilience. The method of processing the spiral patterns on the inner and outer surfaces of this tubular fabric is as follows:

[0062] The steps of Method 1 are:

[0063] A. As Figure 8 A first textured line 101 is wound around a metal tube 100 in a spiral pattern from the first end to the second end in the axial direction. During the winding, the drive mechanism 102 drives the metal tube 100 to rotate, and the wire bundle forming the first textured line is released from the winding reel 103.

[0064] B. A tubular fabric 200 is placed over the outer sheath of a metal tube that has been wound with the first textured line;

[0065] C. For example Figure 9 Then, a second patterned thread 104 is wound around the metal tube that has been fitted with tubular weave 200 in an axial direction from the first end to the second end in a spiral pattern, and the second patterned thread 104 is located between the loops of adjacent second patterned threads when it is wound; during the winding, the drive mechanism 102 drives the metal tube 100 to rotate, and the wire bundle forming the second patterned thread is released from the winding reel 103.

[0066] D. Remove the second textured line and remove the tubular fabric from the metal tube to form a dense polyester artificial blood vessel with internal and external spiral textures.

[0067] The steps for Method Two are:

[0068] a. Take a metal tube with a threaded protrusion extending axially from the first end to the second end.

[0069] b. Cover the metal tube with a tubular fabric;

[0070] c. Then, a spiral pattern is wound around the metal tube that has been fitted with tubular fabric in the axial direction from the first end to the second end, and the spiral pattern is located between the loops of the adjacent spiral protrusions when the spiral pattern is wound.

[0071] d. Remove the textured lines and remove the tubular fabric from the metal tube to form a dense polyester artificial blood vessel with internal and external spiral patterns.

[0072] Both methods involve inserting a tubular fabric into a metal tube of the same inner diameter. The metal tube has spiral protrusions extending axially from one end to the other. Then, a textured pattern is wound around the metal tube with the fabric in a spiral pattern, also extending axially from one end to the other. This textured pattern is positioned between loops of adjacent spiral protrusions. This method overcomes the problems of slow processing, high employee learning costs, and inconsistent molding quality associated with traditional manual glass tube winding techniques.

[0073] The above description is merely a preferred embodiment of the present invention and does not limit the patent scope of the present invention. Any equivalent structural or procedural transformations made based on the content of the present invention's specification and drawings, or direct or indirect applications in other related technical fields, are similarly included within the patent protection scope of the present invention.

Claims

1. A dense polyester artificial blood vessel, which is formed by weaving polyester fibers into a tubular fabric and then processing spiral grooves on the inner and outer surfaces of the tubular fabric; characterized in that: The micropores of this tubular fabric are less than 10 μm; ​ The method for forming tubular fabrics using polyester fiber weaving is as follows: Polyester fibers are twisted to form S-twist and Z-twist. The two fibers twisted in different directions are arranged side by side to form a cohesive structure, namely, the A combination. Several A combinations are processed side-by-side and closely onto the warping head using a warping machine, which is called B combination; A combination A is wound onto a small shaft using a slitting device, which is combination C; The B group is placed on the loom frame as the warp yarn head, and the tension of the A group in the B group is made consistent with the tension between 2g and 1200g to facilitate stable weaving. Set the C combination on the weft disc for weft weaving; Tubular fabrics are formed by weaving combinations B and C; The spiral pattern is processed on the inside and outside of the tubular fabric as follows: A. A first textured line is wound around the outside of a metal tube in a spiral pattern from the first end to the second end in the axial direction. B. A tubular fabric is placed over a metal tube that has been wrapped with the first textured line; C. Then, a second patterning line is wound around the metal tube that has been covered with tubular fabric in an axial direction from the first end to the second end in a spiral pattern, and the second patterning line is located between the loops of the adjacent first patterning line when it is wound. D. Remove the second textured line and remove the tubular fabric from the metal tube to form a dense polyester artificial blood vessel with internal and external spiral textures.

2. The dense polyester artificial blood vessel according to claim 1, characterized in that: When the diameter of the tubular fabric is ≤14mm, the weave spacing is 1±0.2mm and the weave height is 0.5±0.2mm. When the diameter of the tubular fabric is greater than 14 mm, the weave spacing is 2 ± 0.2 mm and the weave height is 1 ± 0.2 mm.

3. The dense polyester artificial blood vessel according to claim 1, characterized in that: This polyester fiber uses polyester fibers with a fineness of 15D to 300D, and its microfilament portion is 30F to 400F, meaning that one polyester fiber is formed by the combination of 30 to 400 monofilament fibers.

4. The dense polyester artificial blood vessel according to claim 1, characterized in that: The tubular fabric is woven by machine, with a warp density of >220 threads / cm and a weft density of >120 threads / cm.

5. The dense polyester artificial blood vessel according to claim 4, characterized in that: The tubular fabric is woven in a satin or plain weave.

6. A dense polyester artificial blood vessel, which is made by weaving polyester fibers into a tubular fabric, and then processing spiral patterns on the inside and outside of the tubular fabric; characterized in that: The micropores of this tubular fabric are less than 10 μm; The method for forming tubular fabrics using polyester fiber weaving is as follows: Polyester fibers are twisted to form S-twist and Z-twist. The two fibers twisted in different directions are arranged side by side to form a cohesive structure, namely, the A combination. Several A combinations are processed side-by-side and closely onto the warping head using a warping machine, which is called B combination; A combination A is wound onto a small shaft using a slitting device, which is combination C; The B group is placed on the loom frame as the warp yarn head, and the tension of the A group in the B group is made consistent with the tension between 2g and 1200g to facilitate stable weaving. Set the C combination on the weft disc for weft weaving; Tubular fabrics are formed by weaving combinations B and C; The spiral pattern is processed on the inside and outside of the tubular fabric as follows: a. Take a metal tube with a threaded protrusion extending axially from the first end to the second end. b. Cover the metal tube with a tubular fabric; c. Then, a spiral pattern is wound around the metal tube that has been fitted with tubular fabric in the axial direction from the first end to the second end, and the spiral pattern is located between the loops of the adjacent spiral protrusions when the spiral pattern is wound. d. Remove the textured lines and remove the tubular fabric from the metal tube to form a dense polyester artificial blood vessel with internal and external spiral patterns.

Images