Intracranial artery repair stent and intracranial artery repair system

Abstract

The invention provides an intracranial artery repair stent and an intracranial artery repair system. The intracranial artery repair system comprises a conveying device and the intracranial artery repair stent. The intracranial artery repair stent comprises a stent body and a whole-body spine which are connected with each other, and the whole-body spine extends in the axial direction of the stent body; the repair stent has a low-porosity area and a high-porosity area; the high-porosity area is used for being supported in a preset pipeline, and the low-porosity area is used for blocking a target cavity; and the length of the low-porosity area in the axial direction of the stent main body is matched with the length of the opening of the target chamber on the preset pipeline. The repair stent is provided with the whole-body spine, and the whole-body spine has the performance of being incapable of axially stretching, so that the repair stent is not shortened or shifted in the implanting process, and accurate positioning and releasing of the intracranial artery repair stent can be achieved. Meanwhile, the repair stent can effectively shorten the design length of the low-porosity area, so that the length of the low-porosity area only covers the opening of the target chamber, the target chamber can be blocked, and the smoothness of the branch pipeline can be ensured.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to an intracranial artery repair stent and an intracranial artery repair system. Background Art

[0002] Intracranial aneurysms are abnormal bulges in intracranial arteries caused by localized damage to the vessel wall due to congenital anomalies or post-natal injury. Under the influence of hemodynamic stress and other factors, they gradually expand and form abnormal bulges. The incidence of intracranial aneurysms in the general population is approximately 3% to 5%, and the annual probability of aneurysm rupture is approximately 0.95%. Once an aneurysm forms, it is likely to rupture, ranking third among cerebrovascular accidents, after cerebral thrombosis and hypertensive intracerebral hemorrhage. Subarachnoid hemorrhage (SAH) can be fatal if an aneurysm ruptures. Intracranial aneurysms are the leading cause of subarachnoid hemorrhage (SAH). According to statistics, approximately 10% of patients with aneurysmal SAH die before reaching the hospital, 25% die within 24 hours, and 40% to 49% die within three months. The mortality rate is estimated to be as high as 65%, with most patients dying in the early clinical stages. Therefore, cerebral aneurysms are like a ticking time bomb buried in the brain, threatening to explode at any moment. Therefore, timely intervention of intracranial aneurysms is very important. Common intervention sites include the internal carotid artery system (accounting for 85%-95%) and the vertebral-basilar artery system (accounting for 5%-15%).

[0003] Currently, the main treatments for intracranial aneurysms include surgical clipping and endovascular treatment. With technological advancements and the minimally invasive and rapid recovery characteristics of interventional treatment, endovascular treatment for intracranial aneurysms has rapidly developed, and the safety and effectiveness of endovascular treatment for intracranial aneurysms have been confirmed in multiple large-scale clinical studies.

[0004] However, the anatomical structure of intracranial blood vessels is complex, especially the deeper intracranial arteries, such as the middle cerebral artery and the anterior cerebral artery, which are tortuous and have numerous small branches, which pose challenges to the interventional treatment of intracranial aneurysms. In order to achieve good results in the interventional treatment of intracranial aneurysms, it is necessary to accurately position and release the interventional stent to block the aneurysm while keeping the branch vessels unobstructed. In the prior art, since the implanted stent (such as an aneurysm auxiliary stent or a blood flow guiding device) is very prone to shortening and displacement when released from the delivery device, the operator needs superb manipulation skills to accurately position and release the implanted stent and ensure the patency of the branch vessels after the stent is implanted. Summary of the Invention

[0005] In order to solve the problems existing in the prior art, the present invention provides an intracranial artery repair stent and an intracranial artery repair system. The repair stent does not shorten or shift during the implantation process, and can achieve accurate positioning and release of the intracranial artery repair stent. At the same time, the repair stent can effectively shorten the design length of the low-porosity area, so that the length of the low-porosity area only covers the target cavity opening, which can not only achieve the occlusion of the target cavity, but also ensure the patency of the branch pipeline.

[0006] To achieve the above-mentioned objectives, the present invention provides an intracranial artery repair stent for blocking a target chamber on a predetermined pipeline, wherein the repair stent comprises a stent body and a through-body spine that are interconnected, wherein the through-body spine extends axially along the stent body; the repair stent has a low-porosity region and a high-porosity region that are axially arranged in sequence; the high-porosity region is used to support the predetermined pipeline, and the low-porosity region is used to block the target chamber; the axial length of the low-porosity region of the stent body matches the length of the target chamber on the predetermined pipeline.

[0007] Optionally, a plurality of groups of development marks are provided on the stent body or the through-body spine, wherein two groups of development marks are respectively located at two ends of the low-porosity area.

[0008] Optionally, the development mark is provided on the full-body spine, or the development mark is provided on the stent body in an area close to the full-body spine.

[0009] Optionally, the development marks are arranged on the whole body spine and in an area on the stent body close to the whole body spine; the whole body spine has at least one group of the development marks, and at least one group of the development marks on the whole body spine is arranged at the distal end and / or proximal end of the whole body spine; the stent body has at least three groups of the development marks, and the development marks on the stent body are respectively arranged at both ends of the low porosity zone and the high porosity zone.

[0010] Optionally, the through-body spine is a part of the stent body, or the through-body spine is arranged on the inner wall or outer wall of the stent body.

[0011] Optionally, the spine is arc-shaped.

[0012] Optionally, the number of the through-body spines is one or more; when the number of the through-body spines is more than one, the multiple through-body spines are spaced apart in the circumferential direction of the stent body.

[0013] Optionally, the cross-sectional shape of the spine in the low-porosity region is circular or rectangular, and the cross-sectional shape of the spine in the high-porosity region is also circular or rectangular.

[0014] Optionally, the mesh shape of the low porosity zone and / or the mesh shape of the high porosity zone is triangular, quadrilateral, hexagonal or long strip. When the mesh shape of the low porosity zone is long strip, it can allow large-sized external instruments to enter the target cavity.

[0015] Optionally, the cross-sectional shape of the low porosity zone is annular or partially annular, and the cross-sectional shape of the high porosity zone is also annular or partially annular; the outer diameter of the low porosity zone after release and the outer diameter of the high porosity zone after release both match the inner diameter of the predetermined pipeline.

[0016] Optionally, the number of the high-porosity regions is two, the number of the low-porosity region is one, and the two high-porosity regions are connected to both ends of the low-porosity region respectively.

[0017] Alternatively, the number of the high-porosity region is one, the number of the low-porosity region is one, and the high-porosity region is arranged at one end of the low-porosity region.

[0018] Optionally, the low-porosity area further includes a filter screen, which is covered on the inner wall or outer wall of the bracket body in the low-porosity area, and the mesh size of the filter screen is smaller than the mesh size of the bracket body in the low-porosity area.

[0019] To achieve the above-mentioned object, the present invention further provides an intracranial artery repair system, comprising a delivery device and any one of the intracranial artery repair stents described above, wherein the delivery device is used to deliver the intracranial artery repair stent.

[0020] Optionally, the delivery device includes a delivery wire, a sleeve and a shaft, the shaft having two spaced-apart blocks, the sleeve being sleeved on the shaft and movably disposed between the two blocks; the intracranial artery repair stent is connected to one of the sleeve and the shaft, and the delivery wire is connected to the other of the sleeve and the shaft.

[0021] The present invention provides an intracranial artery repair stent and an intracranial artery repair system. The repair stent includes a full-body spine. Since the full-body spine has the property of being non-axially stretchable, the axial length of the intracranial artery repair stent remains unchanged in the gripping state and the released state. This can effectively avoid shortening and displacement during the release process of the repair stent, thereby achieving high-precision positioning and release of the repair stent.

[0022] At the same time, such a configuration can also effectively shorten the design length of the low-porosity zone, so that the length of the low-porosity zone only covers the neck of the aneurysm. It can not only achieve effective occlusion of the aneurysm, but also reduce the probability of the low-porosity zone covering the branch vessels, so that the low-porosity zone minimizes the impact on the branch vessels and the tumor-bearing vessels, ensuring the patency of the branch vessels on the intracranial tumor-bearing artery. It is very suitable for the treatment of intracranial aneurysms, especially the vascular anatomical structure of deep intracranial aneurysms and intracranial arteries with numerous branches, which can bring greater clinical benefits to patients.

[0023] The stent also features a zoned design with varying porosities. A high-porosity zone of a defined length is designed at one or both ends of the low-porosity zone. The low-porosity zone is used to accurately seal the aneurysm ostium through imaging markings, while the high-porosity zone is anchored to the conduit near the aneurysm. This allows the stent to be stably anchored within the intended conduit, ensuring the sealing effect of the low-porosity zone and improving the stability of the stent implant and the effectiveness of the treatment. Furthermore, the larger mesh size of the high-porosity zone ensures the patency of branch vessels, preserving the possibility of secondary interventional treatment and enhancing treatment efficacy. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 This is a schematic structural diagram of an intracranial artery repair stent in a preferred embodiment of the present invention;

[0025] Figure 2 This is a schematic diagram of a usage scenario of an intracranial artery repair stent in a preferred embodiment of the present invention, wherein the shape of the predetermined pipeline is an arc;

[0026] Figure 3a This is a schematic structural diagram of the bracket body in a preferred embodiment of the present invention;

[0027] Figure 3b This is a schematic structural diagram of the bracket body in another preferred embodiment of the present invention;

[0028] Figure 3c This is a structural diagram of the bracket body in another preferred embodiment of the present invention;

[0029] Figure 3d This is a structural diagram of the bracket body in another preferred embodiment of the present invention;

[0030] Figure 3e This is a structural diagram of the bracket body in another preferred embodiment of the present invention;

[0031] Figure 3f This is a structural diagram of the bracket body in another preferred embodiment of the present invention;

[0032] Figure 4a This is a schematic structural diagram of the entire spine in a preferred embodiment of the present invention;

[0033] Figure 4b This is a schematic structural diagram of a full-body spine in another preferred embodiment of the present invention;

[0034] Figure 4c This is a schematic structural diagram of a full-body spine in another preferred embodiment of the present invention;

[0035] Figure 5a FIG1 is a schematic front view of the structure of an intracranial artery repair stent in a preferred embodiment of the present invention, wherein arrow y indicates that the intracranial artery repair stent bends up and down due to the bending moment in the y direction (horizontal direction);

[0036] Figure 5b This is a schematic side view of the structure of an intracranial artery repair stent in a preferred embodiment of the present invention, wherein arrow z indicates that the intracranial artery repair stent is subjected to circumferential torsion due to torque;

[0037] Figure 5c FIG1 is a schematic diagram of a top view of an intracranial artery repair stent according to a preferred embodiment of the present invention, wherein the arrow x indicates that the intracranial artery repair stent is subjected to a bending moment in the x-direction (vertical direction) and bends left and right;

[0038] Figure 6 This is a schematic diagram of a usage scenario of an intracranial artery repair stent in a preferred embodiment of the present invention, wherein the shape of the predetermined pipeline is S-shaped;

[0039] Figure 7a This is a schematic structural diagram of an intracranial artery repair stent in another preferred embodiment of the present invention;

[0040] Figure 7b This is a schematic structural diagram of an intracranial artery repair stent in another preferred embodiment of the present invention;

[0041] Figure 8a Schematic diagram of a use scenario of an intracranial artery repair stent in a preferred embodiment of the present invention, wherein both the low-porosity area and the high-porosity area are non-circular in design;

[0042] Figure 8b This is a schematic diagram of a usage scenario of an intracranial artery repair stent in another preferred embodiment of the present invention, wherein the low-porosity area is a non-circular design and the high-porosity area is a circular design;

[0043] Figure 9 A schematic structural diagram of a conveying device in a preferred embodiment of the present invention;

[0044] Figure 10 This is a schematic structural diagram of an intracranial artery repair stent in another preferred embodiment of the present invention;

[0045] Figure 11aThis is a schematic diagram of a usage scenario of an intracranial artery stent before deployment in a preferred embodiment of the present invention, wherein the development marks at both ends of the low-porosity region of the stent before deployment are located on both sides of the entrance of the target cavity;

[0046] Figure 11b This is a schematic diagram of a usage scenario after the distal high-porosity region of the intracranial artery repair stent is released in the first preferred embodiment of the present invention;

[0047] Figure 11c This is a schematic diagram of a usage scenario after the intracranial artery repair stent is completely released in the first preferred embodiment of the present invention;

[0048] Figure 11d This is a schematic diagram of a usage scenario of the final implantation state of the intracranial artery repair stent in the first preferred embodiment of the present invention;

[0049] Figure 12a This is a schematic diagram of a usage scenario of an intracranial artery stent before being deployed in a preferred embodiment 2 of the present invention, wherein the development marks at both ends of the low-porosity region of the stent before deployment are located on both sides of the entrance of the target cavity;

[0050] Figure 12b This is a schematic diagram of a usage scenario after the distal high-porosity region of the intracranial artery repair stent is released in the second preferred embodiment of the present invention;

[0051] Figure 12c This is a schematic diagram of a usage scenario after the intracranial artery repair stent is completely released in the second preferred embodiment of the present invention;

[0052] Figure 12d This is a schematic diagram of a usage scenario of the final implantation state of the intracranial artery repair stent in the second preferred embodiment of the present invention;

[0053] Figure 13a This is a schematic diagram of a usage scenario of an intracranial artery stent before deployment in a third preferred embodiment of the present invention, wherein the development marks at both ends of the low-porosity region of the stent before deployment are located on both sides of the entrance of the target cavity;

[0054] Figure 13b This is a schematic diagram of a usage scenario after the distal low-porosity region of the intracranial artery repair stent is released in the third preferred embodiment of the present invention;

[0055] Figure 13c This is a schematic diagram of a usage scenario after the intracranial artery repair stent is completely released in the third preferred embodiment of the present invention;

[0056] Figure 13d This is a schematic diagram of a usage scenario of the final implantation state of the intracranial artery repair stent in the third preferred embodiment of the present invention;

[0057] Figure 14a This is a schematic structural diagram of an intracranial artery repair stent in a fourth preferred embodiment of the present invention;

[0058] Figure 14b This is a schematic structural diagram of another intracranial artery repair stent in a fourth preferred embodiment of the present invention;

[0059] Figure 15a This is a schematic diagram of a usage scenario of the intracranial artery stent before being released in the fifth preferred embodiment of the present invention;

[0060] Figure 15b This is a schematic diagram of a usage scenario after the distal high-porosity region of the intracranial artery repair stent is released in the fifth preferred embodiment of the present invention;

[0061] Figure 15c This is a schematic diagram of a usage scenario in which the intracranial artery repair stent is fully released in the fifth preferred embodiment of the present invention;

[0062] Figure 15d This is a schematic diagram of a usage scenario in which the proximal end of the intracranial artery repair stent is anchored to the pipeline on the other side of the target cavity in the fifth preferred embodiment of the present invention;

[0063] Figure 15e This is a schematic diagram of a usage scenario of the final implantation state of the intracranial artery repair stent in the fifth preferred embodiment of the present invention;

[0064] Figure 16a This is a schematic diagram of a usage scenario of the intracranial artery stent before being released in the sixth preferred embodiment of the present invention;

[0065] Figure 16b This is a schematic diagram of a usage scenario after the distal high-porosity region of the intracranial artery repair stent is released in the sixth preferred embodiment of the present invention;

[0066] Figure 16c This is a schematic diagram of a usage scenario after the intracranial artery repair stent is completely released in the sixth preferred embodiment of the present invention;

[0067] Figure 16d This is a schematic diagram of a usage scenario in which the proximal end of the intracranial artery repair stent is anchored to the pipeline on the other side of the target cavity in the sixth preferred embodiment of the present invention;

[0068] Figure 16e This is a schematic diagram of a usage scenario of the final implantation state of the intracranial artery repair stent in the sixth preferred embodiment of the present invention;

[0069] Figure 17a This is a schematic diagram of a use scenario of an intracranial artery repair stent with a straight spine according to a seventh preferred embodiment of the present invention, wherein the predetermined conduit has a bifurcated aneurysm with an arc-shaped branch at the top;

[0070] Figure 17bThis is a schematic diagram of a use scenario of the intracranial artery repair stent with an arc-shaped spine in the seventh preferred embodiment of the present invention, wherein the predetermined conduit has a top bifurcation aneurysm with an arc-shaped branch;

[0071] Figure 18a Schematic diagram of the structure of an intracranial artery repair stent in a seventh preferred embodiment of the present invention, wherein the cross-sectional shapes of the low-porosity region and the high-porosity region of the intracranial artery repair stent are both annular;

[0072] Figure 18b Schematic diagram of the structure of another intracranial artery repair stent in a seventh preferred embodiment of the present invention, wherein the cross-sectional shape of the low-porosity region and the cross-sectional shape of the high-porosity region of the intracranial artery repair stent are both annular;

[0073] Figure 19a Schematic diagram of the structure of an intracranial artery repair stent in a seventh preferred embodiment of the present invention, wherein the cross-sectional shapes of the low-porosity region and the high-porosity region of the intracranial artery repair stent are both partially annular;

[0074] Figure 19b Schematic diagram of the structure of another intracranial artery repair stent in a seventh preferred embodiment of the present invention, wherein the cross-sectional shape of the low-porosity region of the intracranial artery repair stent is partially circular, and the cross-sectional shape of the high-porosity region of the intracranial artery repair stent is circular;

[0075] Figure 19c for Figure 19a Schematic diagram of the three-dimensional structure of the middle intracranial artery repair stent;

[0076] Figure 20a Schematic diagram of the structure of an intracranial artery repair stent in preferred embodiment eight of the present invention, wherein the spine of the intracranial artery repair stent is straight;

[0077] Figure 20b Schematic diagram of the structure of another intracranial artery repair stent in the eighth preferred embodiment of the present invention, wherein the spine of the intracranial artery repair stent is arc-shaped;

[0078] Figure 21a This is a schematic diagram of a usage scenario of the intracranial artery stent before being released in the ninth preferred embodiment of the present invention;

[0079] Figure 21b This is a schematic diagram of a usage scenario after the distal high-porosity region of the intracranial artery repair stent is released in the ninth preferred embodiment of the present invention;

[0080] Figure 21c This is a schematic diagram of a usage scenario after the intracranial artery repair stent is completely released in the ninth preferred embodiment of the present invention;

[0081] Figure 21dThis is a schematic diagram of a scenario in which the intracranial artery repair stent is anchored in a pipeline on the other side of the target cavity in the ninth preferred embodiment of the present invention;

[0082] Figure 21e This is a schematic diagram of a usage scenario in which a packing device penetrates a target cavity and fills a packing medium after an intracranial artery repair stent is anchored in a ninth preferred embodiment of the present invention;

[0083] Figure 21f This is a schematic diagram of the usage scenario of the packing device after packing is completed in the ninth preferred embodiment of the present invention.

[0084] In the picture:

[0085] Predetermined pipeline 10; target chamber 20;

[0086] Repair stent 100; delivery catheter 200;

[0087] Low porosity area 1; high porosity area 2; full-body spine 3; full-body spine 31 in the low-porosity area; full-body spine 32 in the high-porosity area; stent body 4; stent body 41 in the low-porosity area; stent body 42 in the high-porosity area; development marker 5; sleeve 61; shaft 62; block 63; filter screen 7; aneurysm packing device 8. DETAILED DESCRIPTION

[0088] The present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments. The advantages and features of the present invention will become more apparent from the following description. It should be noted that the drawings are greatly simplified and not to exact scale, and are only used to facilitate and clearly illustrate the embodiments of the present invention.

[0089] Terms such as "center," "longitudinal," "transverse," "length," "width," "thickness," "up," "down," "front," "back," "left," "right," "vertical," "horizontal," "top," "bottom," "inside," "outside," "clockwise," "counterclockwise," "axial," "radial," and "circumferential" indicate positions or locations based on those shown in the accompanying drawings. These terms are intended solely to facilitate description and simplify the present invention and are not intended to indicate or imply that the mechanisms or components referred to must have, be constructed, or operate in a specific orientation. These terms are not to be construed as limiting the present invention. The term "proximal end" generally refers to the end closest to the operator; the term "distal end" is the end opposite the "proximal end" and generally refers to the end farther from the operator.

[0090] In the present invention, unless otherwise specified or limited, the terms "installed," "connected," "fixed," and the like should be understood broadly. For example, they may refer to fixed connections, detachable connections, or integration; mechanical connections, electrical connections, or communication between them; direct connections or connections through an intermediate medium; and internal communication between two components or interaction between two components, unless otherwise specified. Those skilled in the art will understand the specific meanings of the above terms in the present invention based on specific circumstances.

[0091] The present invention will be described in detail below with reference to the accompanying drawings and preferred embodiments. In the absence of conflict, the following embodiments and features therein may complement or be combined with each other.

[0092] Reference Figure 1 and Figure 2 As shown, a preferred embodiment of the present invention provides an intracranial artery repair stent for occluding a target cavity 20 on a predetermined conduit 10. The repair stent 100 includes a through-body spine 3 and a stent body 4 connected to each other. The through-body spine 3 extends axially along the stent body 4, and the length of the through-body spine 3 matches the length of the stent body 4.

[0093] Furthermore, the repair stent 100 has a low-porosity region 1 and a high-porosity region 2 arranged in sequence axially. In one example, the low-porosity region 1 and the high-porosity region 2 are connected axially along the stent body 4. In another example, the low-porosity region 1 and the high-porosity region 2 are spaced apart axially along the stent body 4 and connected by a through-body spine 3.

[0094] Furthermore, the axial length of the low-porosity region 1 of the stent body 4 matches the opening length of the target cavity 20 on the predetermined conduit 10. The high-porosity region 2 is used to support the predetermined conduit 10, and the low-porosity region 1 is used to block the target cavity 20. Preferably, the low-porosity region 1 includes a through-body spine 3 for blocking the target cavity 20. The through-body spine 3 is used to prevent the low-porosity region 1 and the high-porosity region 2 from axial shortening during the release process.

[0095] Reference Figure 1 and Figure 2 , multiple groups of imaging marks 5 are provided on the stent body 4 or the whole body spine 3. Two groups of imaging marks 5 are respectively located at the two ends of the low porosity area 1 along its own axial direction.

[0096] It should be noted that the predetermined pipeline 10 generally refers to an intracranial artery, and the target chamber 20 on the predetermined pipeline 10 generally refers to an aneurysm on the intracranial artery.

[0097] Typically, an intracranial artery repair stent enters the intracranial artery through the internal carotid artery system or the vertebral-basilar artery system. The intracranial artery repair stent can be released at the aneurysm location of the intracranial artery and block the artery.

[0098] More specifically, the stent body 4 has a compressed state and a released state. When the stent body 4 is loaded into the delivery device, the stent body 4 is in the compressed state. After at least a portion of the stent body 4 is removed from the delivery device, the stent body 4 transitions from the compressed state to the released state and is positioned within the predetermined conduit 10.

[0099] Furthermore, the outer diameter of the stent body 4 after release matches the inner diameter of the predetermined pipeline 10 , so that the stent body 4 is anchored in the predetermined pipeline 10 after release.

[0100] The present application provides an intracranial artery repair stent, which includes a full-body spine 3. Since the full-body spine 3 has the property of being non-axially stretchable, the axial length of the intracranial artery repair stent remains unchanged in the gripping state and the released state. This can effectively avoid shortening and displacement during the release process of the repair stent 100, thereby achieving high-precision positioning and release of the repair stent 100.

[0101] At the same time, such a configuration can also effectively shorten the length of the low-porosity zone 1, so that the designed length of the low-porosity zone 1 only covers the neck of the aneurysm. It can not only achieve effective occlusion of the aneurysm, but also effectively avoid the phenomenon that the branch blood vessels near the aneurysm are blocked due to increasing the designed length of the low-porosity zone 1 in order to completely occlude the aneurysm, thereby reducing the probability of the low-porosity zone 1 covering the branch blood vessels, so that the low-porosity zone 1 minimizes the impact on the branch blood vessels and the tumor-bearing blood vessels, ensuring the patency of the branch blood vessels on the intracranial tumor-bearing artery. It is very suitable for the treatment of intracranial aneurysms, especially the vascular anatomical structure of deep intracranial aneurysms and intracranial arteries with numerous branches, which can bring greater clinical benefits to patients.

[0102] In addition, the repair stent 100 features a zoned design with varying porosities. A high-porosity zone 2 of a certain length is designed at one or both ends of the low-porosity zone 1. The low-porosity zone 1 is used to accurately seal the aneurysm ostium using a radiographic marker 5. The high-porosity zone 2 is anchored to the conduit 10 near the aneurysm, allowing the repair stent 100 to be stably anchored within the intended conduit 10, ensuring the sealing effect of the low-porosity zone 1 and improving the implant stability and treatment effectiveness of the repair stent 100. Furthermore, the larger mesh size of the high-porosity zone 2 ensures the patency of branch vessels, retaining the possibility of secondary interventional treatment and enhancing treatment efficacy.

[0103] The present application does not limit the material of the stent body 4. The stent body 4 can preferably be made of a metal material, such as a shape memory alloy, stainless steel, or a degradable metal. Furthermore, the stent body 4 can also be made of a polymer material, such as a degradable polymer material.

[0104] In addition, the stent body 4 can be manufactured in various ways, such as laser cutting, weaving, and chemical etching, but is not limited thereto.

[0105] Reference Figure 3a to Figure 3f The mesh shape of the support body 41 in the low porosity area and / or the mesh shape of the support body 42 in the high porosity area is a triangle, a quadrilateral, a hexagon or a long strip.

[0106] Reference Figure 3a to Figure 3c As shown, the mesh shape of the stent body 4 is preferably triangular, quadrilateral and hexagonal. In this case, the stent body 4 has an array grid structure with equal sizes in the axial and circumferential directions, which is more stable and can more effectively block the aneurysm opening.

[0107] Reference Figure 3d to Figure 3f As shown, the mesh shape of the stent body 4 is preferably elongated. The stent body 42 in the high-porosity region has a mesh structure with an axial dimension that is significantly smaller or significantly larger than the circumferential dimension. This structure allows a microcatheter to pass through the stent body 42 in the high-porosity region, enabling secondary intervention in branch vessels. The elongated mesh shape of the low-porosity region 1 allows larger external devices (such as aneurysm packing devices) to enter the target lumen 20, thereby achieving embolization of the aneurysm.

[0108] Reference Figure 1 and Figure 2 As shown, in some embodiments, the visualization mark 5 is provided on the through-body spine 3. In other embodiments, the visualization mark 5 is provided in a region of the stent body 4 near the through-body spine 3. For example, the low-porosity region 1 includes a low-porosity stent body 41, and the high-porosity region 2 includes a high-porosity stent body 42. The visualization mark 5 can be provided in a region near the through-body spine 3 on the stent body 41 in the low-porosity region and / or the stent body 42 in the high-porosity region (i.e., the visualization mark 5 is provided in a region near the through-body spine 3).

[0109] In some other embodiments, the visualization markers 5 are disposed on the entire spine 3 and in an area near the entire spine 3 on the stent body 41. The entire spine 3 has at least one set of visualization markers 5, and at least one set of visualization markers 5 on the entire spine 3 is disposed at the distal end and / or proximal end of the entire spine 3. The stent body 41 has at least three sets of visualization markers 5, and the visualization markers 5 on the stent body 41 are disposed at both ends of the low-porosity region 1 and at both ends of the high-porosity region 2, respectively.

[0110] Continue to refer to Figure 1 and Figure 2 As shown, in one example, there are two groups of development marks 5, and the two groups of development marks 5 are set at the two ends of the low-porosity region 1 along its own axis. The distance between the development marks 5 at both ends of the low-porosity region 1 matches the distance between the two ends of the neck of the aneurysm, so that the low-porosity region 1 of the repair stent 100 can effectively block the aneurysm.

[0111] During actual implantation, the low-porosity region 1 can be positioned at the aneurysm opening through the development mark 5. The advantage of designing the development mark 5 is that, on the one hand, it can achieve highly precise positioning and release of the repair stent 100, and on the other hand, the length of the low-porosity region 1 can be shortened during design so that the low-porosity region 1 just covers the aneurysm neck opening. The shorter low-porosity region 1 can better ensure the patency of the branch blood vessels.

[0112] Reference Figure 10 As shown, in another example, the number of development marks 5 is four groups, wherein development marks 5 are respectively provided at both ends of the low-porosity region 1, and development marks 5 are also respectively provided at both ends of the stent body 4, which helps to accurately position the low-porosity region 1 of the repair stent 100 at the aneurysm on the intracranial artery.

[0113] As a preferred solution, the whole spine 3 is a part of the stent body 4. In this case, the repair stent 100 can be formed into the stent body 4 including the whole spine 3 by laser cutting.

[0114] As another preferred embodiment, the through-body spine 3 is disposed on the inner or outer wall of the stent body 3. In this case, the repair stent 100 can be formed into the stent body 4 by laser cutting or weaving, and then the columnar or sheet-like through-body spine 3 is fixed to the inner or outer wall of the stent body 4 to form the repair stent 100.

[0115] The repair stent 100 provided by the present invention can achieve aneurysm occlusion treatment solely through the low-porosity region 1. When the mesh size of the low-porosity region 1 in the circumferential direction is significantly larger or significantly smaller than its axial dimension, the low-porosity region 1 can serve as a support and auxiliary embolization device for aneurysm packing. Furthermore, when the low-porosity region 1 is changed to a medium-porosity region or a high-porosity region, the low-porosity region 1 can also serve as a support and auxiliary embolization device for aneurysm packing.

[0116] In a preferred embodiment, the number of high porosity regions 2 is two, and the number of low porosity regions 1 is one, that is, the repair stent 100 includes one low porosity region 1 and two high porosity regions 2 (refer to Figure 1), the two high-porosity regions 2 are respectively connected to the two ends of the low-porosity region 1, that is, the two high-porosity regions 2 are respectively arranged at the proximal and distal ends of the low-porosity region 1, so as to better support the repair bracket 100 in the predetermined pipeline 10.

[0117] In another preferred embodiment, the number of high porosity regions 2 is one, and the number of low porosity regions 1 is one, that is, the repair stent 100 includes one low porosity region 1 and one high porosity region 2 (refer to Figure 1 The high porosity region 2 is disposed at one end of the low porosity region 1 , that is, the high porosity region 2 can be located proximal or distal to the low porosity region 1 to adapt to complex vascular anatomical structures.

[0118] Reference Figure 4a to Figure 4c As shown, the cross-sectional shape of the through-body ridgepole 31 in the low-porosity region is circular or rectangular, and the cross-sectional shape of the through-body ridgepole 32 in the high-porosity region is also circular or rectangular.

[0119] Reference Figure 4a and Figure 4b In some embodiments, the number of the through-body vertebrae 31 in the low-porosity region is one, the number of the through-body vertebrae 32 in the high-porosity region is two, and the two through-body vertebrae 32 in the high-porosity region are respectively arranged at the two ends of the through-body vertebrae 31 in the low-porosity region.

[0120] As an alternative, the cross-sectional shape of the spine 31 throughout the low porosity region is circular, and the cross-sectional shape of the spine 32 throughout the high porosity region is rectangular. As another alternative, the cross-sectional shape of the spine 31 throughout the low porosity region is rectangular, and the cross-sectional shape of the spine 32 throughout the high porosity region is circular.

[0121] Reference Figure 4c In other embodiments, the number of the through-body vertebrae 31 in the low-porosity zone is one, and the number of the through-body vertebrae 32 in the high-porosity zone is one. The through-body vertebrae 32 in the high-porosity zone can be arranged at one end (for example, the proximal end or the distal end) of the through-body vertebrae 31 in the low-porosity zone.

[0122] Reference Figure 5a to Figure 5c As shown, the spine 3 of the repair stent 100 can have different cross-sectional designs, so that the repair stent 100 has a designed torsional rigidity (refer to FIG. Figure 5b ), upper and lower bending stiffness (refer to Figure 5a ) and left and right bending stiffness (refer to Figure 5c ) so that the repair stent 100 has better compliance with the vascular anatomical structure, thereby achieving high-precision release of the repair stent 100 and improving the sealing effect of the low-porosity area 1.

[0123] In more detail, when the cross-sectional shape of the through-body spine 31 in the low-porosity zone and / or the cross-sectional shape of the through-body spine 32 in the high-porosity zone is circular, the through-body spine 31 in the low-porosity zone and / or the through-body spine 32 in the high-porosity zone have isotropic bending stiffness and excellent torsional stiffness, so that the repair bracket 100 has better overall stability.

[0124] When the cross-sectional shape of the spine 31 in the low-porosity zone and / or the cross-sectional shape of the spine 32 in the high-porosity zone is rectangular, the spine 31 in the low-porosity zone and / or the spine 32 in the high-porosity zone have anisotropic bending stiffness, which can better control the bending stiffness of the repair stent 100 in a specific direction and improve the compliance of the repair stent 100 to blood vessels with specific anatomical structures.

[0125] Reference Figure 6 As shown, when the repair stent 100 needs to be delivered to the bend of the S-shaped intracranial artery to block the aneurysm, the blood vessels on both sides are reversely bent, and the blood vessels at the proximal and distal ends of the aneurysm may be spatially distorted. Figure 6 a is designed so that the repair stent 100 has a better therapeutic effect.

[0126] Specifically, the cross-sectional shape of the high porosity region is a rectangular spine 32 ( Figure 6 The AB and CD segments in the aneurysm can better match the spatial distortion of the intracranial artery proximal and distal to the aneurysm, thereby enabling the spine 32 in the high-porosity area to better fit the inner wall of the aneurysm. Figure 6 The BC segment in the aneurysm has isotropic bending stiffness and high torsional stiffness, so it can maintain good structural stability when the vascular space on both sides of the aneurysm is distorted, further improving the aneurysm occlusion effect.

[0127] like Figure 1 and Figure 2 As shown, the spine 3 can be set to a straight line or an arc shape, and the cross-sectional shape of the spine 3 is preferably matched with the cross-sectional shape of the predetermined pipeline 10, so that the repair stent 100 can better fit the inner wall of the predetermined pipeline 10. For example, when the spine 3 of the repair stent 100 is designed to be arc-shaped, the spine 3 can make the repair stent 100 better fit the aneurysm on the greater curvature side of the arc-shaped blood vessel, thereby achieving a better blocking effect (refer to Figure 2 ).

[0128] The whole-body spine 3 of the repair stent 100 provided in the present application can have a specific shape design. For example, the whole-body spine 3 can be set to a straight line or an arc shape so that the shape of the whole-body spine 3 matches the structure of the tumor-bearing artery, which helps the repair stent 100 to adapt to the complex intracranial vascular anatomical structure, further improve the low-porosity area 1 of the repair stent 100 and the wall adhesion of the intracranial artery, and achieve more effective blockage.

[0129] Reference Figure 1 、 Figure 7a and Figure 7b As shown, the number of the whole body spine 3 is one or more. When the number of the whole body spine 3 is more than one, the multiple whole body spines 3 are spaced apart in the circumferential direction of the stent body 4, further improving the release stability of the repair stent 100.

[0130] like Figure 7a As shown, in a specific example, there are two through-body spines 3 , and the two through-body spines 3 are arranged on opposite sides of the stent body 4 .

[0131] like Figure 7b As shown, in another specific example, the number of the through-body spines 3 is four, and the four through-body spines 3 are evenly or unevenly arranged in the circumferential direction of the stent body 4 .

[0132] Furthermore, the cross-sectional shape of the low-porosity zone can be set to be annular or partially annular, and the cross-sectional shape of the high-porosity zone can also be set to be annular or partially annular (i.e., an arc structure less than 360 degrees), and the outer diameter of the low-porosity zone 1 after release and the outer diameter of the high-porosity zone 2 after release are both matched with the inner diameter of the predetermined pipeline 10, so that the repair bracket 100 can be sealed and anchored in the predetermined pipeline 10.

[0133] Reference Figure 8a and Figure 8b As shown, in a preferred case, in the axial direction of the stent body 4 , the cross-sectional area of ​​the low-porosity region 1 and / or the cross-sectional area of ​​the high-porosity region 2 changes gradually.

[0134] In a specific example, the cross-sectional shape of the high porosity region 2 and the cross-sectional shape of the low porosity region 1 are both partially annular, and the cross-sectional shape of the low porosity region 1 gradually increases from the middle position to both ends along the axial direction of the stent body 4, and the cross-sectional shapes at both ends of the low porosity region 1 are partially annular (refer to Figure 8a In another specific example, the cross-sectional shape of the high porosity region 2 is annular, the cross-sectional shape of the low porosity region 1 is partially annular, and the cross-sectional shape of the low porosity region 1 gradually increases from the middle position to both ends along the axial direction of the stent body 4, and the cross-sectional shapes of the two ends of the low porosity region 1 are annular (refer to Figure 8bBoth of the above-mentioned two embodiments are adaptable to the treatment needs of aneurysms at the bifurcation of intracranial arteries, and can maintain the patency of the main blood vessels and branch blood vessels to the greatest extent possible while effectively blocking the aneurysm with the repair stent 100.

[0135] Reference Figure 1 As shown, the cross-sectional shape of the low-porosity region 1 and the cross-sectional shape of the high-porosity region 2 can also be set to be ring-shaped, so that the repair stent 100 can be firmly fixed in the blood vessel.

[0136] A preferred embodiment of the present invention further provides an intracranial artery repair system, comprising a delivery device and any one of the intracranial artery repair stents described above, wherein the delivery device is used to deliver the intracranial artery repair stent.

[0137] Reference Figure 9 As shown, as a preferred embodiment, the delivery system includes a delivery wire (not shown), a sleeve 61, and a shaft 62. The shaft 62 has two spaced-apart blocks 63. The sleeve 61 is sleeved on the shaft 62 and movably disposed between the two blocks 63. The intracranial artery repair stent is connected to one of the sleeve 61 and the shaft 62, and the delivery wire is connected to the other of the sleeve 61 and the shaft 62. At this time, the repair stent 100 and the delivery wire can move and rotate relative to each other, which can prevent the repair stent 100 from twisting and deforming during delivery and achieve a limited axial displacement constrained connection between the repair stent 100 and the delivery device. This method helps the repair stent 100 to conform to the vascular anatomical structure, especially for non-circumferentially designed repair stents 100, which can be effectively delivered and improve the low-porosity region 1 of the repair stent 100 to block aneurysms, further improving the effectiveness of the intracranial artery repair system.

[0138] The structure of the intracranial artery repair stent is described below through specific examples.

[0139] <Example 1>

[0140] Reference Figure 10 As shown, in this embodiment, the repair stent 100 includes a low-porosity region 1 and two high-porosity regions 2. The two high-porosity regions 2 are connected to the two ends of the low-porosity region 1. Development marks 5 are respectively provided at both ends of the low-porosity region 1 and at both ends of the repair stent 100.

[0141] Furthermore, the repair stent 100 is preferably laser-cut from a shape memory alloy material, wherein the low-porosity region 1 is preferably configured as a dense diamond pattern with smaller diamond meshes, and the high-porosity region 2 is preferably configured as a sparse diamond pattern with larger diamond meshes.

[0142] Figures 11a to 11dThe figure shows the process of accurately positioning and releasing the repair stent 100 through the delivery catheter 200. When the repair stent 100 is delivered through the delivery catheter 200, it is first implanted into the predetermined conduit 10 through the delivery catheter 200. During the delivery and positioning process of the repair stent 100, the imaging marks 5 at both ends of the low-porosity region 1 of the repair stent 100 are located on both sides of the target cavity 20, so that the low-porosity region 1 can block the aneurysm. At this time, the repair stent 100 can be prepared for release (refer to Figure 11a ).

[0143] Then, the delivery catheter 200 can be withdrawn to achieve the gradual release of the repair stent 100. During the withdrawal of the delivery catheter 200, the high porosity region 2 at the distal end of the repair stent 100 begins to be released in situ (refer to Figure 11b Due to the effect of the through-body spine 3, the repair stent 100 does not shorten during release. The axial length of the repair stent 100 remains unchanged before and after release. At this time, the repair stent 100 can still remain in the delivery position during the release process. In other words, after the high-porosity region 2 at the distal end of the repair stent 100 is released, the position of the low-porosity region 1 of the repair stent 100 does not change. The low-porosity region 1 can block the aneurysm orifice, thereby achieving precise positioning and in-situ release of the repair stent 100.

[0144] Afterwards, as the delivery catheter 200 is gradually withdrawn, the low porosity region 1 and the proximal high porosity region 2 of the repair stent 100 are gradually released. The low porosity region 1 and the proximal high porosity region 2 will not shrink during the release process. After the repair stent 100 is fully released, the low porosity region 1 can still be accurately distributed at the aneurysm orifice (refer to Figure 11c ).

[0145] After the repair stent 100 is implanted and fully released, the delivery catheter 200 is withdrawn from the body, and the high porosity regions 2 at both ends of the repair stent 100 can be firmly anchored in the predetermined conduit 10 (refer to Figure 11d On the one hand, the low-porosity region 1 of the repair stent 100 is ensured to always effectively block the aneurysm; on the other hand, the high-porosity region 2 does not block the branch vessels of the predetermined conduit 10, thereby ensuring the patency of the branch vessels on the intracranial artery.

[0146] <Example 2>

[0147] In this embodiment, the repair stent 100 includes a low porosity region 1 and a high porosity region 2. The high porosity region 2 is arranged at one end of the low porosity region 1. Figure 12a In the figure, the high porosity region 2 is arranged at the distal end of the low porosity region 1. The development marks 5 are arranged at the proximal and distal ends of the low porosity region 1 and the distal end of the repair stent 100, respectively.

[0148] Figures 12a to 12d The figure shows the process of accurately positioning and releasing the repair stent 100 through the delivery catheter 200. When the repair stent 100 is delivered through the delivery catheter 200, it is first implanted into the predetermined conduit 10 through the delivery catheter 200. During the delivery and positioning process of the repair stent 100, the imaging marks 5 at both ends of the low-porosity region 1 of the repair stent 100 are located on both sides of the target cavity 20, so that the low-porosity region 1 can block the aneurysm. At this time, the repair stent 100 can be prepared for release (refer to Figure 12a ).

[0149] Then, the delivery catheter 200 can be withdrawn to achieve the gradual release of the repair stent 100. During the withdrawal of the delivery catheter 200, the high porosity region 2 at the distal end of the repair stent 100 begins to be released in situ (refer to Figure 12b After the high-porosity region 2 at the distal end of the repair stent 100 is released, the position of the low-porosity region 1 of the repair stent 100 does not change. At this time, the low-porosity region 1 can block the aneurysm opening, achieving precise in-situ release of the repair stent 100.

[0150] Afterwards, as the delivery catheter 200 is gradually withdrawn, the low porosity region 1 of the repair stent 100 is gradually released, and the low porosity region 1 and the proximal high porosity region 2 do not shrink during the release process. After the repair stent 100 is fully released, the low porosity region 1 can still be accurately distributed at the aneurysm orifice (refer to Figure 12c ).

[0151] After the repair stent 100 is implanted and fully released, the delivery catheter 200 is withdrawn from the body, and the high porosity region 2 at the distal end of the repair stent 100 can be firmly anchored in the predetermined conduit 10 (refer to Figure 12d On the one hand, the low-porosity region 1 of the repair stent 100 is ensured to always effectively occlude the aneurysm; on the other hand, the high-porosity region 2 does not occlude the branch vessels of the predetermined conduit 10, thereby ensuring the patency of the branch vessels on the intracranial artery. Moreover, the high-porosity region 2 is provided only distal to the low-porosity region 1, further reducing the impact of the repair stent 100 on the proximal branch vessels of the aneurysm and allowing it to accommodate more complex aneurysm anatomical structures.

[0152] <Example 3>

[0153] In this embodiment, the repair stent 100 includes a low porosity region 1 and a high porosity region 2. The high porosity region 2 is arranged at one end of the low porosity region 1. Figure 13aIn the figure, the high-porosity region 2 is located proximal to the low-porosity region 1. Visual markers 5 are located proximal and distal to the low-porosity region 1, as well as at the proximal end of the stent repair 100. This design minimizes the space occupied by the stent repair 100 in the distal artery of the aneurysm and is suitable for anatomies with narrowed or extremely tortuous distal arteries.

[0154] Figures 13a to 13d The figure shows the process of accurately positioning and releasing the repair stent 100 through the delivery catheter 200. When the repair stent 100 is delivered through the delivery catheter 200, the imaging marks 5 at both ends of the low porosity area 1 of the repair stent 100 are first positioned on both sides of the target cavity 20 (refer to Figure 13a Then, the delivery catheter 200 is gradually withdrawn, and the low-porosity region 1 at the distal end of the repair stent 100 begins to be released in situ (refer to Figure 13b After the repair stent 100 is fully released, the low porosity area 1 can be accurately distributed at the aneurysm opening (refer to Figure 13c ) to achieve effective closure of the aneurysm. After the repair stent 100 is implanted and fully released, the delivery catheter 200 is withdrawn from the body, and the high porosity region 2 at the proximal end of the repair stent 100 can be firmly anchored in the predetermined conduit 10 (refer to Figure 13d ).

[0155] <Example 4>

[0156] Reference Figure 14a and Figure 14b As shown, in this embodiment, the repair stent 100 includes a low porosity area 1 and a high porosity area 2. Figure 14a In the figure, the high porosity region 2 is located at the proximal end or distal end of the low porosity region 1. The development marks 5 are respectively set at both ends of the low porosity region 1 and the proximal end of the repair stent 100.

[0157] Furthermore, the outer diameter of the low porosity zone 1 and the outer diameter of the high porosity zone 2 both match the inner diameter of the predetermined pipeline 10, and the cross-sectional shape of the low porosity zone 1 and / or the high porosity zone 2 of the repair stent 100 is partially annular, that is, the low porosity zone 1 and / or the high porosity zone 2 are both non-circular designs, which can ensure that the passages of the main blood vessels and branch blood vessels are unobstructed after the repair stent 100 is implanted.

[0158] It should be noted that when treating intracranial bifurcation aneurysms, since the aneurysm is located at a main vessel and at least two branch vessels, a circumferentially designed stent repair device 100 would block the main vessel or at least one branch vessel, making secondary interventional treatment impossible for the blocked vessel. To accommodate the treatment of intracranial bifurcation aneurysms, this embodiment employs a non-circumferential design for at least a portion of the stent repair device 100, preventing the stent repair device 100 from blocking the main vessel and branch vessels, thereby ensuring that the intracranial arteries and branch vessels remain unobstructed.

[0159] Reference Figure 14a As shown, in a preferred embodiment, the cross-sectional shapes of the low-porosity region 1 and the high-porosity region 2 of the repair stent 100 are both partially annular. In this case, both the low-porosity region 1 and the high-porosity region 2 are non-circular in design. This configuration allows the repair stent 100 to require a smaller delivery system. This smaller delivery system can reach deeper into the intracranial arteries, making it more suitable for treating deep intracranial aneurysms.

[0160] Reference Figure 14b As shown, in a preferred embodiment, at least part of the low-porosity region 1 of the repair stent 100 has a partially annular cross-section, while the high-porosity region 2 has an annular cross-section. In this case, the low-porosity region 1 is non-circular, while the high-porosity region 2 is circumferential. This arrangement provides the high-porosity region 2 of the repair stent 100 with a stronger radial support force, allowing the repair stent 100 to be more firmly anchored at the implant site.

[0161] <Example 5>

[0162] Reference Figures 15a to 15e As shown, in this embodiment, the repair stent 100 includes a low-porosity region 1 and two high-porosity regions 2. The two high-porosity regions 2 are located at both ends of the low-porosity region 1. Visualization marks 5 are respectively provided at both ends of the low-porosity region 1 and at the proximal and distal ends of the repair stent 100.

[0163] Furthermore, the cross-sectional shape of one high-porosity region 2 is annular, and the cross-sectional shape of at least a portion of the low-porosity region 1 and the cross-sectional shape of another high-porosity region 2 are both partial annular.

[0164] Reference Figure 15aAs shown, in a specific example, the cross-sectional shape of at least part of the low-porosity region 1 and the cross-sectional shape of the high-porosity region 2 proximal to the low-porosity region 1 are both partially annular, while the cross-sectional shape of the high-porosity region 2 distal to the low-porosity region 1 is annular. That is, the low-porosity region 1 and the distal high-porosity region 2 are both non-circular in design, while the proximal high-porosity region 2 is circumferential in design. The cross-sectional area of ​​the low-porosity region 1 in its own axial direction gradually decreases from the distal end toward the proximal end, thereby achieving a transition from the annular distal high-porosity region 2 to the partially annular proximal high-porosity region 2. This approach has the advantage of simplifying the release of the repair stent 100 and maintaining the patency of all blood vessels.

[0165] In another specific example, the cross-sectional shape of at least part of the low-porosity region 1 and the cross-sectional shape of the high-porosity region 2 at the distal end of the low-porosity region 1 are both partially annular, and the cross-sectional shape of the high-porosity region 2 at the proximal end of the low-porosity region 1 is annular.

[0166] Figures 15a to 15e The figure shows the process of accurately positioning and releasing the repair stent 100 through the delivery catheter 200. When the repair stent 100 is delivered through the delivery catheter 200, the imaging mark 5 at the distal end of the low porosity region 1 of the repair stent 100 is located on one side of the target cavity 20 (refer to Figure 15a Then, the delivery catheter 200 is gradually withdrawn, and the high porosity region 2 at the distal end of the repair stent 100 begins to be released in situ (refer to Figure 15b After the repair stent 100 is completely released, a portion of the repair stent 100 is located in the main vessel, and the other portion is located in the first branch vessel. At this time, the repair stent 100 fails to block the aneurysm (refer to Figure 15c The proximal end of the repair stent 100 is smoothly guided and pushed into the second branch vessel by the pre-shaped delivery wire. The imaging markers 5 at both ends of the low-porosity region 1 can be located on both sides of the aneurysm orifice. The low-porosity region 1 can be accurately distributed at the aneurysm orifice to achieve effective occlusion of the aneurysm (refer to Figure 15d After the repair stent 100 is implanted and fully released, the delivery catheter 200 is withdrawn from the body, and the high porosity regions 2 at both ends of the repair stent 100 can be firmly anchored in the predetermined conduit 10 (refer to Figure 15e ), thereby improving the overall stability of the repair bracket 100.

[0167] <Example 6>

[0168] Reference Figures 16a to 16e As shown, in this embodiment, the repair stent 100 includes a low-porosity region 1 and a high-porosity region 2. The high-porosity region 2 is located at the distal end of the low-porosity region 1. Development marks 5 are respectively provided at both ends of the low-porosity region 1 and at the distal end of the repair stent 100.

[0169] Furthermore, the cross-sectional shape of the low-porosity zone 1 is partially annular, and the cross-sectional shape of the high-porosity zone 1 is annular, that is, the low-porosity zone 1 is a non-circular design, and the high-porosity zone 2 is a circumferential design. The cross-sectional area of ​​the low-porosity zone 1 gradually decreases from the distal end to the proximal end to achieve a non-circumferential design of the low-porosity zone 1. The advantage of this is that it simplifies the release of the repair stent 100 and enables all blood vessels to remain unobstructed. At the same time, this design does not require the repair stent 100 to be released into the second branch vessel, and is suitable for scenarios where the anatomical structure of the second branch vessel is tortuous and the repair stent 100 is difficult to guide into.

[0170] Figures 16a to 16e The figure shows the process of accurately positioning and releasing the repair stent 100 through the delivery catheter 200. When the repair stent 100 is delivered through the delivery catheter 200, the imaging mark 5 at the distal end of the low porosity region 1 of the repair stent 100 is located on one side of the target cavity 20 (refer to Figure 16a Then, the delivery catheter 200 is gradually withdrawn, and the high porosity region 2 at the distal end of the repair stent 100 begins to be released in situ (refer to Figure 16b After the repair stent 100 is completely released, the repair stent 100 is in a bent state, with a portion of the repair stent 100 located in the main vessel and another portion located in the first branch vessel. At this time, the repair stent 100 fails to block the aneurysm (refer to Figure 16c The proximal end of the low-porosity region 1 is smoothly guided to the other side of the aneurysm opening by the pre-shaped delivery wire. The imaging markers 5 at both ends of the low-porosity region 1 can be located on both sides of the aneurysm opening, so that the low-porosity region 1 can be accurately distributed at the aneurysm opening to achieve effective occlusion of the aneurysm (refer to Figure 16d After the repair stent 100 is implanted and fully released, the delivery catheter 200 is withdrawn from the body, and the high porosity region 2 at the distal end of the repair stent 100 can be firmly anchored in the predetermined conduit 10 (refer to Figure 16e ), thereby improving the overall stability of the repair bracket 100.

[0171] <Example 7>

[0172] Reference Figure 17a and Figure 17b As shown, in this embodiment, the repair stent 100 includes a low-porosity region 1 and a high-porosity region 2. The high-porosity region 2 is located at one end (i.e., the proximal end or the distal end) of the low-porosity region 1. The imaging markers 5 are respectively provided at the proximal and distal ends of the low-porosity region 1 and the proximal or distal end of the repair stent 100.

[0173] In a preferred embodiment, the spine 3 is straight. Figure 17a The figure is a schematic diagram of the application scenario of an intracranial repair stent with a straight spine in a apical bifurcation aneurysm with curved branches. Figure 17a As shown, the straight-line spine cannot match the curved branch blood vessels to achieve the fit between the repair stent and both sides of the aneurysm, and thus cannot achieve effective occlusion of the aneurysm opening.

[0174] In another preferred embodiment, the spine 3 is arc-shaped. Figure 17b The figure is a schematic diagram of the application scenario of an intracranial repair stent with an arc-shaped spine at a apical bifurcation aneurysm with an arc-shaped branch. Figure 17b As shown, the arc-shaped repair stent 100 can be used to treat the top bifurcation aneurysm of the intracranial artery with arc-shaped branches. The arc-shaped spine 3 can fit closely to the aneurysm opening, thereby achieving effective occlusion treatment of the bifurcation aneurysm.

[0175] In some embodiments, the cross-sectional shape of the low porosity region 1 and the cross-sectional shape of the high porosity region 2 of the repair stent 100 are both annular. In this case, the low porosity region 1 and the high porosity region 2 are both circumferentially designed, and the shape of the spine 3 of the repair stent 100 is arc-shaped.

[0176] Reference Figure 18a As shown, in one example, the low-porosity region 1 is configured as fine ribs, and the high-porosity region 2 is configured as sparse ribs.

[0177] Reference Figure 18b As shown, in one example, the low porosity zone 1 is set to a fine diamond pattern, that is, the low porosity zone 1 has a smaller diamond mesh; the high porosity zone 2 is set to a sparse diamond pattern, that is, the high porosity zone 2 has a larger diamond mesh.

[0178] Reference Figure 19a and Figure 19c As shown, in other embodiments, the cross-sectional shapes of the low-porosity region 1 and the high-porosity region 2 of the repair stent 100 are both partially annular. In this case, the low-porosity region 1 and the high-porosity region 2 are both non-circular in design, and the shape of the spine 3 throughout the repair stent 100 is arc-shaped. The low-porosity region 1 is configured as fine ribs, while the high-porosity region 2 is configured as sparse ribs.

[0179] Reference Figure 19b As shown, in some other embodiments, the cross-sectional shape of the low-porosity region 1 of the repair stent 100 is partially annular, while the cross-sectional shape of the high-porosity region 2 is annular. In this case, the low-porosity region 1 is non-circular, while the high-porosity region 2 is circumferential. The shape of the spine 3 throughout the repair stent 100 is arc-shaped. The low-porosity region 1 is configured with a fine diamond mesh, while the high-porosity region 2 is configured with a sparse diamond mesh.

[0180] <Embodiment 8>

[0181] Reference Figure 20a and Figure 20b As shown, in this embodiment, the repair stent 100 includes a low-porosity region 1 and a high-porosity region 2. The high-porosity region 2 is located proximal or distal to the low-porosity region 1. Visualization marks 5 are respectively provided at the proximal and distal ends of the low-porosity region 1 and the proximal or distal end of the repair stent 100.

[0182] Furthermore, the cross-sectional shape of the low porosity region 1 of the repair stent 100 is partially circular, and the cross-sectional shape of the high porosity region 2 is circular. In this case, the low porosity region 1 is non-circular in design, and the high porosity region 2 is circumferential in design. The shape of the spine 3 of the repair stent 100 is linear (refer to Figure 20a ) or arc (refer to Figure 20b ). The low porosity area 1 is set to a fine diamond mesh, and the high porosity area 2 is set to a sparse diamond mesh.

[0183] In this embodiment, the low-porosity region 1 further includes a filter 7 (e.g., a woven mesh) that covers the inner or outer wall of the stent body 41 in the low-porosity region. The mesh size of the filter 7 is smaller than that of the stent body 41 in the low-porosity region. The low-porosity region 1 with the filter 7 can enhance the aneurysm occlusion effect. This allows the outer diameter of the crimping grip of the low-porosity region 1 to be reduced while maintaining the occlusion effect, thereby reducing the size of the delivery system and making the intracranial artery repair system suitable for treating deeper intracranial aneurysms.

[0184] <Example 9>

[0185] The parts of this embodiment that are the same as those of the sixth embodiment will not be described in detail, and only the differences will be described below.

[0186] In this embodiment, the mesh of the low-porosity region 1 is in the shape of an elongated strip. The elongated strip of mesh allows an aneurysm packing device to pass through and enter the target cavity, thereby achieving embolization treatment of the aneurysm.

[0187] Figures 21a to 21f The figure shows the process of accurately positioning and releasing the repair stent 100 through the delivery catheter 200. When the repair stent 100 is delivered through the delivery catheter 200, the imaging mark 5 at the distal end of the low porosity region 1 of the repair stent 100 is located on one side of the target cavity 20 (refer to Figure 21a Then, the delivery catheter 200 is gradually withdrawn, and the high porosity region 2 at the distal end of the repair stent 100 begins to be released in situ (refer to Figure 21b After the repair stent 100 is completely released, the repair stent 100 is in a bent state, with a portion of the repair stent 100 located in the main vessel and another portion located in the first branch vessel. At this time, the repair stent 100 fails to block the aneurysm (refer to Figure 21cThe proximal end of the low-porosity region 1 is smoothly guided to the other side of the aneurysm opening by the pre-shaped delivery wire. The imaging markers 5 at both ends of the low-porosity region 1 can be located on both sides of the aneurysm opening, so that the low-porosity region 1 can be accurately distributed at the aneurysm opening to achieve effective occlusion of the aneurysm (refer to Figure 21d ). The delivery catheter 200 can be withdrawn before or after the aneurysm is packed. After the repair stent 100 is implanted and fully released, the catheter is passed through the stent body 41 of the low-porosity area of ​​the aneurysm orifice and the aneurysm packing device 8 is implanted into the aneurysm (refer to Figure 21e After the aneurysm packing device 8 is completely implanted in the aneurysm, the delivery catheter 200 is withdrawn from the body to complete the implantation of the repair stent 100 and the aneurysm packing device 8. After implantation, the high porosity region 2 of the repair stent 100 can be firmly anchored in the predetermined conduit 10, and the low porosity region 1 of the repair stent 100 can block the target chamber 20 and support the aneurysm packing device 8 in the aneurysm (refer to Figure 21f ), which improves the stability of aneurysm packing and the effectiveness of treatment.

[0188] In summary, the present invention provides an intracranial artery repair stent and an intracranial artery repair system. The repair stent 100 includes a full-body spine 3. Since the full-body spine 3 has the property of not being axially stretchable, the axial length of the intracranial artery repair stent remains unchanged in the gripping state and the released state. This can effectively avoid shortening and displacement during the release process of the repair stent 100, thereby achieving high-precision positioning and release of the repair stent 100.

[0189] At the same time, such a configuration can also effectively shorten the length of the low-porosity zone 1, so that the length of the low-porosity zone 1 only covers the neck of the aneurysm. It can not only achieve effective occlusion of the aneurysm, but also effectively avoid the phenomenon that the branch blood vessels near the aneurysm are blocked due to increasing the design length of the low-porosity zone 1 in order to completely occlude the aneurysm, and reduce the probability of the low-porosity zone 1 covering the branch blood vessels, so that the low-porosity zone 1 minimizes the impact on the branch blood vessels and the tumor-bearing blood vessels, ensuring the patency of the branch blood vessels on the intracranial tumor-bearing artery. It is very suitable for the treatment of intracranial aneurysms, especially the vascular anatomical structure of deep intracranial aneurysms and intracranial arteries with numerous branches, which can bring greater clinical benefits to patients.

[0190] The above description is only a description of the preferred embodiments of the present invention and does not limit the scope of the present invention. Any changes and modifications made by ordinary technicians in the field of the present invention based on the above disclosure are within the scope of protection of the present invention.

Claims

1. An intracranial artery repair stent for blocking a target cavity on a predetermined pipeline, characterized in that: The repair stent includes a stent body and a through-body spine that are interconnected, and the through-body spine extends axially along the stent body; the repair stent has a low-porosity zone and a high-porosity zone that are axially arranged in sequence; the high-porosity zone is used to support the predetermined pipeline, and the low-porosity zone is used to block the target chamber; the length of the low-porosity zone in the axial direction of the stent body matches the length of the target chamber on the predetermined pipeline.

2. The intracranial artery repair stent according to claim 1, wherein: A plurality of groups of development marks are provided on the stent body or the through-body spine, wherein two groups of development marks are respectively located at two ends of the low-porosity area.

3. The intracranial artery repair stent according to claim 2, characterized in that: The visualization mark is arranged on the whole body spine, or the visualization mark is arranged on the area of ​​the stent body close to the whole body spine.

4. The intracranial artery repair stent according to claim 2, wherein: The development marks are arranged on the whole body spine and in the area of ​​the stent body close to the whole body spine; the whole body spine has at least one group of the development marks, and at least one group of the development marks on the whole body spine is arranged at the distal end of the whole body spine and / or the proximal end of the whole body spine; the stent body has at least three groups of the development marks, and the development marks on the stent body are respectively arranged at both ends of the low porosity area and the high porosity area.

5. The intracranial artery repair stent according to claim 1, wherein: The through-body spine is a part of the stent body, or the through-body spine is arranged on the inner wall or outer wall of the stent body.

6. The intracranial artery repair stent according to claim 1, characterized in that: The whole spine is arc-shaped.

7. The intracranial artery repair stent according to claim 1, characterized in that: The number of the through-body spine is one or more; when the number of the through-body spine is more than one, the multiple through-body spines are spaced apart in the circumferential direction of the stent body.

8. The intracranial artery repair stent according to claim 1, wherein: The cross-sectional shape of the spine in the low-porosity region is circular or rectangular, and the cross-sectional shape of the spine in the high-porosity region is also circular or rectangular.

9. The intracranial artery repair stent according to any one of claims 1 to 8, characterized in that: The mesh shape of the low porosity area and / or the mesh shape of the high porosity area is triangular, quadrilateral, hexagonal or long strip. When the mesh shape of the low porosity area is long strip, it can allow large-sized external instruments to enter the target cavity.

10. The intracranial artery repair stent according to any one of claims 1 to 8, characterized in that: The cross-sectional shape of the low porosity zone is annular or partially annular, and the cross-sectional shape of the high porosity zone is also annular or partially annular; the outer diameter of the low porosity zone after release and the outer diameter of the high porosity zone after release both match the inner diameter of the predetermined pipeline.

11. The intracranial artery repair stent according to claim 10, characterized in that: There are two high-porosity regions and one low-porosity region, and the two high-porosity regions are connected to both ends of the low-porosity region respectively. Alternatively, the number of the high-porosity region is one, the number of the low-porosity region is one, and the high-porosity region is arranged at one end of the low-porosity region.

12. The intracranial artery repair stent according to claim 10, characterized in that: The low-porosity area further includes a filter screen, which is covered on the inner wall or outer wall of the support body in the low-porosity area. The mesh size of the filter screen is smaller than the mesh size of the support body in the low-porosity area.

13. An intracranial artery repair system, characterized in that: The invention comprises a delivery device and the intracranial artery repair stent according to any one of claims 1 to 12, wherein the delivery device is used for delivering the intracranial artery repair stent.

14. The intracranial artery repair system according to claim 13, wherein: The delivery device includes a delivery wire, a sleeve and a shaft, the shaft is provided with two spaced-apart blocks, the sleeve is sleeved on the shaft and movably arranged between the two blocks; the intracranial artery repair stent is connected to one of the sleeve and the shaft, and the delivery wire is connected to the other of the sleeve and the shaft.

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