Bactericidal composition containing benziothiazolinone and trifluoropyridinamine

Abstract

The invention provides a bactericidal composition containing benziothiazolinone and trifluoropyridylamine, wherein the weight ratio of benziothiazolinone to trifluoropyridylamine in the bactericidal composition is (1: 80)-(80: 1). The bactericidal composition disclosed by the invention has a synergistic effect on prevention and treatment of agricultural diseases, especially crop diseases caused by fusarium, in a limited ratio range. The invention also relates to a method and application of the composition for preventing and treating agricultural diseases.

Description

Technical Field

[0001] The invention belongs to the field of agriculture, and particularly relates to a bactericidal composition containing thiabendazim and trifluoperazine and an application thereof. Background Art

[0002] Triflupyramide is a novel succinate dehydrogenase inhibitor (SDHI) fungicide developed by Syngenta. Its unique chemical structure, combining phenylcyclobutyl and pyridineamide groups, significantly controls diseases caused by Fusarium species (such as F. graminearum and F. graminearum) and various nematodes. Triflupyramide exerts its fungicidal effect by inhibiting the respiration of pathogens, interfering with complex II of the respiratory electron transport chain, inhibiting the tricarboxylic acid cycle, and blocking energy (ATP) production, thereby effectively inhibiting their growth. Triflupyramide is primarily used to control wheat stem rot, among other diseases.

[0003] Thiamethoxam, also known as 1,2-benzisothiazolin-3-one, is a novel, highly effective, low-toxic, broad-spectrum fungicide belonging to the isothiazole class of heterocyclic compounds. Its mechanism of action is primarily through binding to anions or sulfhydryl groups on the surface of bacterial cell membranes, disrupting the nuclear structure, protein synthesis, and cell membrane synthesis, interfering with bacterial cell metabolism, inhibiting bacterial reproduction, and ultimately killing the pathogen. This compound has demonstrated excellent control effects against bacterial and fungal diseases in crops and is highly safe for crops.

[0004] Thiamethoxam is an effective fungicide commonly used to control a variety of diseases, including wheat stem rot. In soil treatment, it can be applied via seed coating or seed dressing to control wheat stem rot. It can also be combined with other fungicides, such as tebuconazole, fludioxonil, and prothioconazole, for spraying on wheat to control stem rot and fusarium head blight.

[0005] Wheat crown rot (FCR) is a soil-borne fungal disease caused by various Fusarium species, including Fusarium pseudograminearum and Fusarium graminearum. It primarily affects the base of wheat stems, causing plant lodging, death, and even crop failure. The pathogen can survive for long periods of time in soil or diseased debris through mycelium and conidia, and is spread through tillage. It primarily infects the base of the wheat stem, causing browning and rot of the leaf sheaths and stalks at the base. In severe cases, the roots turn yellow and rot. High humidity during the grain-filling period can cause a pink or grayish-white mold layer to form on the internodes at the base of the stem, making the stem susceptible to breakage and resulting in white ears. This affects wheat yield and quality, making it a significant disease in major wheat-producing regions worldwide.

[0006] No reports on the combination of thiabendazole and trifluoperazine were found in the prior art. Summary of the Invention

[0007] The present invention relates to a fungicide composition containing thiamethoxam and trifluralin. Studies have shown that thiamethoxam and trifluralin have a synergistic effect in preventing and controlling agricultural diseases, and are particularly suitable for preventing and controlling wheat stem rot.

[0008] The present invention is accomplished through the following technical solutions.

[0009] One aspect of the present invention relates to a fungicide composition, wherein the active ingredients of the fungicide composition contain thiamethoxam and trifluralin, and the weight ratio of thiamethoxam to trifluralin is 1:80 to 80:1.

[0010] In a preferred embodiment of the present invention, the weight ratio of thiophanate-methyl to trifluralin is 1:40 to 40:1.

[0011] In a further preferred embodiment of the present invention, the weight ratio of thiophanate-methyl to trifluoperazine is 1:20 to 20:1, for example, 20:1, 19:1, 18:1, 17:1, 16:1, 15:1, 14:1, 13:1, 12:1, 11:1, 10:1, 9:1, 8:1, 7:1, 6:1, 5:1, 4:1, 3:1, 2:1, 1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, 1:9, 1:10, 1:11, 1:12, 1:13, 1:14, 1:15, 1:16, 1:17, 1:18, 1:19, 1:20. The weight ratio of thiophanate-methyl to trifluralin is more preferably 1:1 to 1:20, further preferably 1:4 to 1:16, and particularly preferably 1:8 to 1:16.

[0012] In one embodiment of the present invention, the fungicidal composition further comprises an agriculturally acceptable adjuvant and / or carrier to be prepared into an agriculturally acceptable formulation.

[0013] in,

[0014] The agricultural formulation includes one or more of a suspension seed coating agent, a suspension concentrate, a microemulsion, a suspoemulsion, an emulsion in water, an emulsifiable concentrate, a wettable powder, and a water-dispersible granule. Preferably, the formulation is one or more of a suspension seed coating agent, a suspension concentrate, and a water-dispersible granule. More preferably, the formulation is a suspension seed coating agent or a suspension concentrate.

[0015] The agriculturally acceptable adjuvant and / or carrier includes: one or more of a dispersant, a wetting agent, an emulsifier, a solvent, a thickener, an adhesive, an antifreeze agent, a defoaming agent, a stabilizer, a disintegrant, a warning color, a film-forming agent, and a filler.

[0016] The dispersant includes but is not limited to: one or more of lignin sulfonate, nonylphenol polyoxyethylene ether, polyoxyethylene alkyl aryl ether, polyoxyethylene lanolin alcohol, fatty alcohol polyoxyethylene ether, fatty alcohol polyoxyethylene ether phosphate, alkyl naphthalene sulfonate, naphthalenesulfonic acid formaldehyde condensate sodium salt, sodium p-hydroxyphenyl lignin sulfonate, fatty alcohol polyoxyethylene ether sulfate, alkylphenol polyoxyethylene ether formaldehyde condensate, alkyl dimethyl benzyl ammonium salt, p-methoxy fatty acid amide benzene sulfonic acid, p-methoxy fatty acid amide benzene sulfonate, and polyoxyethylene sorbitan fatty acid ester.

[0017] The wetting agent includes, but is not limited to, one or more of sodium lauryl sulfate, calcium dodecylbenzenesulfonate, sodium lauroyl sarcosinate, fatty alcohol polyoxyethylene ether, dioctyl sulfosuccinate, polyoxyethylene alkyl aryl ether phosphate, trisiloxane polyoxyethylene ether, sodium isooctyl succinate sulfonate, sodium oleoyl methyl taurate, triphenethyl phenol polyoxyethylene ether, castor oil polyoxyethylene ether, polyoxyethylene fatty acid ester, and sorbitan fatty acid ester.

[0018] The emulsifier includes but is not limited to: one or more of lignin sulfonate, sodium dodecyl sulfate, sodium dodecylbenzene sulfonate, calcium dodecylbenzene sulfonate, naphthalene sulfonate formaldehyde condensate, styrylphenyl polyoxyethylene ether, fatty alcohol polyoxyethylene ether, polyoxyethylene alkyl ether, polyoxyethylene sorbitol fatty acid ester, nonylphenol polyoxyethylene ether phosphate, styrene polyoxyethylene ether ammonium sulfate, sorbitan monostearate, and sorbitan monostearate polyoxyethylene ether.

[0019] The solvent includes, but is not limited to, one or more of dimethylformamide, dimethyl sulfoxide, ethanol, acetone, xylene, dichloromethane, ethyl acetate, cyclohexane, cyclohexanone, N-methylpyrrolidone, coconut fatty acid methyl ester, cyclohexanol, methyl glycol ether, and acetonitrile.

[0020] The thickener includes, but is not limited to, one or more of carboxymethyl cellulose, sodium carboxymethyl cellulose, gum arabic, xanthan gum, gelatin, magnesium aluminum silicate, and sodium alginate.

[0021] The binder includes, but is not limited to, one or more of gum arabic, xanthan gum, starch, carboxymethyl cellulose, carboxyethyl cellulose, and gelatin.

[0022] The antifreeze agent includes but is not limited to: one or more of ethylene glycol, propylene glycol, glycerol, and polyethylene glycol.

[0023] The defoaming agent includes but is not limited to: one or more of butyl phosphate, isobutyl phosphate, n-octanol, and silicone.

[0024] The stabilizer includes, but is not limited to, one or more of triphenyl phosphite, epoxidized soybean oil, epoxidized linseed oil, dialkyl succinate sulfonate, butyl glycidyl ether, and the like.

[0025] The disintegrant includes, but is not limited to, one or more of sodium bicarbonate, ammonium sulfate, sodium carboxymethyl starch, sodium sulfate, calcium sulfate, and urea.

[0026] The warning colors include, but are not limited to, one or more of alkaline rhodamine, acid red, acid red B, and acid orange.

[0027] The film-forming agent includes, but is not limited to, one or more of polyvinyl alcohol, gum arabic, carboxymethyl cellulose, and polyethylene glycol.

[0028] The filler / carrier includes solid fillers / carriers and liquid fillers / carriers, including but not limited to: kaolin, bentonite, diatomaceous earth, attapulgite, montmorillonite, calcium carbonate, clay; one or more of water, soybean oil, corn oil, castor oil, rapeseed oil, and mineral oil.

[0029] In one embodiment of the present invention, the total weight percentage of the active ingredients in the fungicidal composition is 5-60%. For example, the total weight percentage of the active ingredients in the fungicidal composition is as low as 5%, 6%, 7%, 8%, 9%, 10%, etc.; the total weight percentage of the active ingredients in the fungicidal composition is as high as 60%, 59%, 58%, 57%, 56%, 55%, 54%, 53%, 52%, 51%, or 50%. In a further embodiment of the present invention, the total weight percentage of the active ingredients in the fungicidal composition is preferably 10-50%, more preferably 10-40%.

[0030] Another aspect of the present invention relates to the use of the fungicide composition of the present invention for preventing and controlling agricultural diseases, wherein the fungicide composition is contacted with the agricultural plant or its propagation material before or after the occurrence of the agricultural disease.

[0031] Applicable crops include wheat, rice, corn, soybean, peanut, rape, cucumber, eggplant, tomato, potato, cabbage, etc. Agricultural diseases for prevention and control include diseases commonly occurring on the crops.

[0032] In a preferred embodiment of the present invention, the crop to which the fungicidal composition of the present invention is applicable is preferably wheat; the agricultural diseases for which the composition is used to prevent and control include wheat stem rot and wheat head blight. Wheat stem rot is primarily caused by Fusarium species such as Fusarium pseudograminearum and Fusarium graminearum. Wheat head blight is primarily caused by Fusarium species such as Fusarium graminearum, Fusarium avenaceum, and Fusarium moniliforme.

[0033] Another aspect of the present invention relates to a method for using the fungicidal composition of the present invention to control agricultural diseases, wherein the fungicidal composition is contacted with the agricultural plant or its propagation material before or after the occurrence of the agricultural disease. The applicable crops and agricultural diseases to be controlled are as described above.

[0034] For example, the fungicide composition of the present invention can be applied to the seeds, leaves, rhizomes, and other parts of the plant to be treated by spraying, root irrigation, seed coating, or seed dressing. The application amount and timing are both within the skill of those skilled in the art, for example, based on the recommended dosage of the agent, the specific disease occurrence, and the drug resistance of the pathogen.

[0035] Beneficial effects:

[0036] The fungicidal composition containing thiabendazim and trifluralin described in the present invention has a synergistic effect on the prevention and treatment of agricultural diseases within the ratio range specified in the present invention, especially for crop diseases caused by Fusarium, such as wheat stem rot and wheat fusarium, and is particularly suitable for the prevention and treatment of wheat stem rot. DETAILED DESCRIPTION

[0037] The present invention will be further described below with reference to the embodiments, but the present invention is not limited thereto.

[0038] The various reagents used in the following examples of the present invention can be obtained commercially or homemade. The plant pathogenic fungi used were cultured in the laboratory. In addition, unless otherwise specified, the percentages described in the following examples are all weight percentages.

[0039] 1. Combined toxicity test

[0040] 1. Determination of the combined toxicity of thiamethoxam and trifluoperazine against Fusarium graminearum. Test pathogenic fungus: Fusarium pseudograminearum;

[0041] Test drugs: Thiamethoxam technical, Trifluoperazine technical;

[0042] Test method: The toxicity of the agent to pathogenic fungi was determined using the growth rate method, with reference to the agricultural industry standard NY / T1156.2006.

[0043] Prepare the drug into a mother solution, then mix it according to the predetermined proportions in Table 1, and prepare 5 concentration gradients with an aqueous solution containing 1% Tween-80, and then add it to the PDA culture medium at 45-50°C, where the volume ratio of the drug solution to the culture medium is 1:9. Mix evenly and pour it into a sterilized culture dish, and form a poisonous culture medium after cooling. Repeat each concentration 3 times. Use an aqueous solution containing 1% Tween-80 as a control. Afterwards, inoculate the pathogen cake into the center of the poisonous culture medium under sterile conditions. Place the culture dish in an incubator with a temperature of 25°C and a humidity of 90% for incubation. When the colony radius on the control plate grows to about 2 / 3 of the plate radius, measure the diameter of each treated colony using the cross-cross method, and calculate the inhibitory growth rate of each agent treatment on the pathogen using the following formula, and calculate the EC of each treatment on the pathogen. 50 .

[0044]

[0045] Then, the EC values ​​of each treatment were determined according to the Sun Yunpei method. 50 Converted into actual toxicity index (ATI); according to the ratio of the mixture, calculated theoretical toxicity index (TTI), calculated the co-toxicity coefficient (CTC) of the mixture according to the following formula, the results are shown in Table 1 below.

[0046]

[0047] Theoretical (mixed) toxicity index (TTI) = toxicity index of A × content of A in the mixture (%)

[0048] + Toxicity index of B × content of B in the mixture (%)

[0049]

[0050] If the co-toxicity coefficient is greater than 120, it indicates a synergistic effect; if the co-toxicity coefficient is less than 80, it indicates an antagonistic effect; and if the co-toxicity coefficient is between 100-120, it indicates an additive effect.

[0051] Table 1 Results of indoor toxicity test

[0052] Pharmacy <![CDATA[EC 50 (mg / L)]]> ATI TTI Co-toxicity coefficient CTC (A) Thiamethoxam 7.38 100.00 - - (B) Trifluridine 2.05 360.00 - - A:B=120:1 7.11 103.80 102.15 101.61 A:B=80:1 6.14 120.20 103.21 116.46 A:B=40:1 5.22 141.38 106.34 132.95 A:B=20:1 4.75 155.37 112.38 138.25 A:B=16:1 4.93 149.70 115.29 129.84 A:B=8:1 4.37 168.88 128.89 131.03 A:B=4:1 3.95 186.84 152.00 122.92 A:B=1:1 2.26 326.55 230.00 141.98 A:B=1:4 1.51 488.74 308.00 158.68 A:B=1:8 1.31 563.36 331.11 170.14 A:B=1:16 1.25 590.40 344.71 171.28 A:B=1:20 1.48 498.65 347.62 143.45 A:B=1:40 1.54 479.22 353.66 135.50 A:B=1:80 1.65 447.27 356.79 125.36 A:B=1:120 2.27 325.11 357.85 90.85

[0053] The results in Table 1 show that thiamethoxam and trifluralin have an additive and synergistic effect in inhibiting Fusarium graminearum. Synergistic effects are observed in the 80:1 to 1:80 ratio range, and are even more pronounced in the 20:1 to 1:20 ratio range. Furthermore, in the 1:1 to 1:20 ratio range, the co-toxicity coefficients exceed 140; in the 1:4 to 1:16 ratio range, the co-toxicity coefficients exceed 150; and in the 1:8 to 1:16 ratio range, the co-toxicity coefficients exceed 170, representing the most preferred ratio ranges for the present invention.

[0054] 2. Combined toxicity test of thiophanate-methyl and trifluoperazine against Fusarium graminearum

[0055] Test pathogenic fungi: Fusarium graminearum;

[0056] The above method was used to determine the combined toxicity of the composition of the present invention against Fusarium graminearum. The results are shown in Table 2 below.

[0057] Table 2 Results of indoor toxicity test

[0058] Pharmacy <![CDATA[EC 50 (mg / L)]]> ATI TTI Co-toxicity coefficient CTC (A) Thiamethoxam 6.88 100.00 - - (B) Trifluridine 2.73 252.01 - - A:B=120:1 6.81 101.03 101.26 99.77 A:B=80:1 5.15 133.59 101.88 131.13 A:B=40:1 4.89 140.70 103.71 135.67 A:B=20:1 4.72 145.76 107.24 135.92 A:B=16:1 4.55 151.21 108.94 138.80 A:B=8:1 4.26 161.50 116.89 138.17 A:B=4:1 3.87 177.78 130.40 136.33 A:B=1:1 2.85 241.40 176.01 137.16 A:B=1:4 2.08 330.77 221.61 149.26 A:B=1:8 1.84 373.91 235.12 159.03 A:B=1:16 1.82 378.02 243.07 155.52 A:B=1:20 1.89 364.02 244.78 148.72 A:B=1:40 2.03 338.92 248.31 136.49 A:B=1:80 2.01 342.29 250.14 136.84 A:B=1:120 2.65 259.62 250.76 103.54

[0059] The results in Table 1 show that thiamethoxam and trifluralin have an additive and synergistic effect in inhibiting Fusarium graminearum. Synergistic effects are observed in the 80:1 to 1:80 ratio range, and are even more pronounced in the 20:1 to 1:20 ratio range. Furthermore, in the 1:1 to 1:20 ratio range, the co-toxicity coefficients exceed 130; in the 1:4 to 1:16 ratio range, the co-toxicity coefficients exceed 140; and in the 1:8 to 1:16 ratio range, the co-toxicity coefficients exceed 150, representing the most preferred ratio ranges for the present invention.

[0060] 2. Preparation Examples

[0061] Example 1: Suspension seed coating agent

[0062] Thiophanate 2%, trifluralin 16%, nonylphenol polyoxyethylene ether 5%, sodium lauroyl sarcosinate 6%, polyvinyl alcohol 5%, magnesium aluminum silicate 3%, ethylene glycol 5%, alkaline rose essence 4%, silicone 0.5%, balance water.

[0063] The preparation method comprises the following steps: adding the components into water, mixing and stirring, and then dispersing and grinding the mixture through high-speed shearing to obtain the suspended seed coating agent.

[0064] Example 2: Suspension seed coating agent

[0065] Thiophanate 1%, trifluralin 16%, sodium naphthalenesulfonic acid formaldehyde condensate 7%, calcium dodecylbenzenesulfonate 5%, polyvinyl alcohol 5%, sodium carboxymethyl cellulose 4%, propylene glycol 4%, alkaline rhodamine 5%, butyl phosphate 0.5%, balance water.

[0066] The preparation method is the same as that of Example 1.

[0067] Example 3 Wettable powder

[0068] Thiophanate 2%, trifluramide 8%, fatty alcohol polyoxyethylene ether 5%, sodium lauryl sulfate 5%, kaolin is made up to 100%.

[0069] The preparation method comprises the following steps: mixing the components, grinding and pulverizing the components to obtain the wettable powder.

[0070] Example 4 Wettable powder

[0071] Thiophanate 1%, trifluralin 20%, sodium naphthalenesulfonic acid formaldehyde condensate 6%, triphenyl phenol polyoxyethylene ether 6%, and bentonite to 100%.

[0072] The preparation method is the same as Example 3.

[0073] Example 5: Suspension

[0074] Thiophanate 3%, trifluralin 12%, polyoxyethylene alkyl aryl ether 7%, triphenyl phenol polyoxyethylene ether 4%, carboxymethyl cellulose 5%, propylene glycol 5%, silicone 0.5%, balance water.

[0075] The preparation method is as follows: each component is added into water, mixed and stirred, and then dispersed and ground by high-speed shearing to obtain a suspension.

[0076] Example 6: Suspension

[0077] Thiophanate 8%, trifluralin 8%, sodium p-hydroxyphenyl lignin sulfonate 4%, dioctyl sodium sulfosuccinate 6%, sodium carboxymethyl cellulose 5%, ethylene glycol 5%, n-octanol 0.5%, and water as the balance.

[0078] The preparation method is the same as Example 5.

[0079] Example 7 Water Dispersible Granules

[0080] Thiophanate 1%, trifluralin 8%, nonylphenol polyoxyethylene ether 5%, polyoxyethylene fatty acid ester 4%, sodium sulfate 4%, gum arabic 2%, and bentonite balance.

[0081] The preparation method comprises the following steps: uniformly mixing and crushing the components except the binder, then adding the binder aqueous solution to granulate the mixture, and drying the mixture to obtain water-dispersible granules.

[0082] Example 8 Water Dispersible Granules

[0083] Thiophanate 1%, trifluralin 16%, sodium naphthalenesulfonic acid formaldehyde condensate 5%, trisiloxane polyoxyethylene ether 7%, sodium sulfate 4%, gum arabic 3%, kaolin balance.

[0084] The preparation method is the same as Example 7.

[0085] Comparative Example 1 Thiophanate suspension seed coating agent

[0086] Thiophanate 18%, nonylphenol polyoxyethylene ether 5%, sodium lauroyl sarcosinate 6%, polyvinyl alcohol 5%, magnesium aluminum silicate 3%, ethylene glycol 5%, alkaline rose essence 4%, silicone 0.5%, balance water.

[0087] The preparation method is the same as that of Example 1.

[0088] Comparative Example 2 Trifluoperazine Suspension Seed Coating Agent

[0089] Trifluralin 18%, Nonylphenol Polyoxyethylene Ether 5%, Sodium Lauroyl Sarcosinate 6%, Polyvinyl Alcohol 5%, Magnesium Aluminum Silicate 3%, Ethylene Glycol 5%, Alkaline Rose Extract 4%, Silicone 0.5%, Balance Water.

[0090] The preparation method is the same as that of Example 1.

[0091] 3. Field control of wheat stem rot

[0092] Test crops: wheat;

[0093] Target: wheat stem rot;

[0094] Test agent: suspension seed coating agent of formulation example 1-2; suspension seed coating agent of comparative example 1-2;

[0095] Experimental design: The wheat stem rot control experiment included two test agent seed dressing treatments, two control agent seed dressing treatments, and one blank control. Each treatment was repeated four times, and a total of 20 field plots were randomly arranged, with each plot area of ​​30m 2 Wheat seeds were treated with each treatment agent at a dosage of 40 g ai / 100 kg of seeds. After treatment, the seeds were dried in a cool place and then sown using a seeder.

[0096] The control effectiveness survey was conducted during the wheat filling period. A five-point sampling method was used in each plot, with 10 plants sampled at each point. A graded survey of the wheat stem base was conducted, and the control effectiveness was calculated based on the disease index.

[0097] The grading standards are:

[0098] Level 0: The entire stem is asymptomatic;

[0099] Level 1: The first leaf sheath at the base of the aboveground part turns brown, but there is no lesion at the stem node;

[0100] Level 3: The first node of the aboveground part turns brown;

[0101] Level 5: The second node of the aboveground part turns brown;

[0102] Level 7: Brown lesions extend beyond the second stem node, but there is no white spike;

[0103] Level 9: Brown lesions extend beyond the second node, resulting in white ears or no ears due to disease;

[0104] The results of the field test are shown in Table 3 below.

[0105] Table 3 Field test results

[0106]

[0107] The results of the field test showed that the fungicidal composition of the present invention has greatly improved control effect on white stem rot compared with single agents of thiamethoxam and trifluralin, and has a synergistic effect.

[0108] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the above embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the above embodiments, or replace some or all of the technical features therein with equivalents. However, these modifications or replacements do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A bactericidal composition, characterized in that The active ingredients of the fungicide composition contain thiamethoxam and trifluralin, and the weight ratio of thiamethoxam to trifluralin is 1:80 to 80:

1.

2. The bactericidal composition according to claim 1, characterized in that The weight ratio of thiophanate-methyl to trifluralin is preferably 1:40 to 40:

1.

3. The bactericidal composition according to claim 2, characterized in that The weight ratio of thiophanate-methyl to trifluralin is more preferably 1:20 to 20:

1.

4. The bactericidal composition according to claim 1, characterized in that The fungicidal composition further comprises an agriculturally acceptable adjuvant and / or carrier and is prepared into an agriculturally acceptable dosage form.

5. The bactericidal composition according to claim 4, characterized in that The agriculturally acceptable adjuvant and / or carrier includes: one or more of a dispersant, a wetting agent, an emulsifier, a solvent, a thickener, an adhesive, an antifreeze agent, a defoaming agent, a stabilizer, a disintegrant, a warning color, a film-forming agent, and a filler.

6. The bactericidal composition according to claim 4, characterized in that The bactericidal composition is prepared into one or more of a suspension seed coating agent, a suspension agent, a microemulsion, a suspoemulsion, an aqueous emulsion, an emulsifiable concentrate, a wettable powder, and a water-dispersible granule.

7. The bactericidal composition according to any one of claims 5 to 6, characterized in that The total weight percentage of active ingredients in the bactericidal composition is 5-60%.

8. Use of the fungicidal composition according to any one of claims 1 to 6 for preventing and controlling agricultural diseases.

9. A method for preventing and controlling agricultural diseases using the fungicidal composition according to any one of claims 1 to 6, characterized in that: The fungicidal composition is brought into contact with the agricultural plant or its propagation material before or after the occurrence of agricultural diseases.

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