A mouse wearable micro-injection device for slow release of salidroside

Abstract

The application discloses a mouse wearable micro-injection device for slow release of rhodiolin, and relates to the technical field of medical miniaturized devices. The device comprises a fixing frame, a slow injection device arranged at the upper end of the fixing frame, and a flow guide device connected with the slow injection device. The slow injection device comprises a syringe body internally provided with a liquid storage area and a reaction area. An injection plug is arranged between the liquid storage area and the reaction area. The side edge of the injection plug is in close contact with the inner wall of the syringe body. The flow guide device is in communication with the liquid storage area. The device can realize accurate control of the drug release rate through three different reaction mechanisms, i.e. gas driving of a drug bin, physical expansion of an expansion bag and composite expansion of an expansion bin. In addition, the design of the hanging ear port in the fixing frame can not only disperse the pressure on the ears, but also reduce the fluctuation range of the mouse's corticosterone level in combination with the lightweight structure design.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of medical miniaturized devices, in particular to a mouse wearable micro-injection device for salidroside sustained release. BACKGROUND

[0002] Salidroside (C14H20O7) needs to be administered frequently to maintain effective blood drug concentration due to its low oral bioavailability (15%-20% in rat model) and short half-life (about 2.5 hours) (Zhang et al., Phytomedicine, 2018). Traditional methods such as daily intraperitoneal injection can easily lead to elevated stress corticosterone levels in mice, interfering with the reliability of neuroprotective experimental results.

[0003] The utility model discloses a medicine liquid infusion mechanism based on the separation of medicine reservoir and injector, including medicine reservoir, reversing valve, valve control device, injector, propelling mechanism and injection needle, the reversing valve includes valve slider and valve housing, and the valve slider is installed in the valve housing, the valve slider is equipped with the slot, and the valve housing is equipped with more than one opening, the opening of the valve housing one side is connected with the medicine reservoir, the opening of the valve housing middle is connected with the injector, and the opening of the valve housing other side is connected with the injection needle, the valve control device includes valve slider clamp and axial electromagnet. The utility model can be fully miniaturized and small, the pipe diameter is thin, the precision is improved according to the proportion of area ratio, reduces the pump body volume under the premise of keeping enough drug amount, is convenient for user to wear, and the medicine reservoir, reversing valve and injector are connected with flexible pipeline, have greater layout freedom, and reduce the use cost of user.

[0004] The above scheme can realize miniaturization and injection of mice, but salidroside has poor stability under physiological conditions (pH 7.4, 37℃), and its aqueous solution has a degradation rate of up to 30-40% within 24 hours, and a half-life of only 6-8 hours under natural light conditions. In addition, repeated injection of salidroside can activate the hypothalamic-pituitary-adrenal axis of mice, leading to significant fluctuations in plasma corticosterone levels. If implanted surgically, 15-20% of mice will develop local infection or tissue adhesion, and the dose before implantation is fixed and cannot be adjusted in real time according to the weight change or drug response of mice during the experiment. That is, reducing the frequency of administration will require an extension of the drug release time, but will affect the stability of the drug. Improving the stability of the drug requires complex packaging, which will increase the size of the device and the trauma of implantation. SUMMARY

[0005] The purpose of this invention is to provide a mouse-worn micro-injection device for sustained release of rhodioloside, in order to solve the problems mentioned in the background art.

[0006] To achieve the above objectives, the present invention provides the following technical solution: a mouse-worn micro-injection device for sustained release of rhodioloside, comprising a frame, a slow-release syringe disposed on the upper end of the frame, and a flow guide connected to the slow-release syringe. The slow-release syringe includes a syringe body having an internal reservoir and a reaction zone. An injection plug is disposed between the reservoir and the reaction zone, and the side of the injection plug is in contact with the inner wall of the syringe body. The flow guide is connected to the reservoir.

[0007] The syringe body has an injection port connected to the reaction zone and a drug injection port connected to the reservoir on both sides of its upper end. Both the injection port and the drug injection port are filled with rubber. One end of the syringe body is connected to the flow guide, and the other end is provided with a sealing cap. The reaction zone is provided with a movable reaction component. The sealing cap is located on the side of the movable reaction component. The injection plug moves due to the movement of the movable reaction component and injects the drug in the reservoir into the outside.

[0008] Furthermore, the fixing frame includes a mouthpiece, a head fixing piece, and multiple extension pieces connected in sequence. The strap piece at the end of the mouthpiece and the head adapter ports on both sides of the head fixing piece are fixedly connected by a head fixing strap. The fixing ears on both sides of the syringe body and the extension pieces are fixedly connected by auxiliary fixing straps.

[0009] The mouthpiece has mouth rings on both sides, and the end of the flow guide passes through the mouth rings and the ear hook located on the side of the head adapter fits into the mouse's ear.

[0010] Furthermore, the active reaction components include, but are not limited to, a deformable drug cartridge, an expansion pack, and an expansion chamber, and the injection plug moves due to changes in the drug cartridge, expansion pack, and expansion chamber, while the volume of the reaction zone containing the drug cartridge / expansion pack is smaller than the volume of the reaction zone containing the expansion chamber.

[0011] Furthermore, a pill is placed inside the medicine compartment located in the middle of the sealed cover. The pill is isolated from the reaction zone by an aluminum foil, and the pill and the injection plug are positioned opposite each other. At the same time, the pill falls into the interior of the reaction zone by pressing the medicine compartment and breaking the aluminum foil.

[0012] Furthermore, the pill includes a pill body, the outer surface of which is provided with a wax seal layer, and the wax seal layer is provided with a notch, through which the pill body contacts the interior of the reaction zone.

[0013] Further, the expansion bag arranged on the side of the injection plug towards the reaction area comprises an expansion cavity, a plurality of expansion medicine layers and a plastic sealing belt, the expansion cavity and the plurality of expansion medicine layers are arranged in the interior of the plastic sealing belt, and the expansion cavity and the expansion medicine layers and the adjacent two expansion medicine layers are spaced by cotton sheets.

[0014] The plastic sealing belt is provided with a plurality of through holes at the end close to the expansion medicine layer, and the expansion medicine layer is communicated with the interior of the reaction area through the through holes.

[0015] Further, the injection plug comprises two pistons connected by a connecting rod, and the piston towards the liquid storage area is provided with an arc-shaped groove on the outward side, and the middle part of the arc-shaped groove is matched with the end part of the flow guide, and the side surface of the piston towards the reaction area is tightly and perpendicularly arranged between the inner wall of the syringe body.

[0016] Further, the interior of the expansion bin arranged on the side of the injection plug is filled with solid expansion material and a flow guide strip, the expansion bin and the reaction area are spaced by a spacer, and the end part of the flow guide strip penetrates through the spacer and is communicated with the interior of the reaction area.

[0017] Further, the flow guide strip arranged in the interior of the expansion bin is provided with redundancy, and the end part of the flow guide strip is connected to the side edge of the injection plug in a wave shape.

[0018] Further, the injection plug comprises two pistons connected by a connecting rod, and the side surface of the piston is tightly and perpendicularly arranged between the inner wall of the syringe body.

[0019] Compared with the prior art, the beneficial effects of the present application are:

[0020] Firstly, the present application can realize the accurate regulation of the drug release rate through three different reaction mechanisms, i.e. the gas driving of the medicine bin, the physical expansion of the expansion bag and the composite expansion of the expansion bin, and the design of the hanging ear port in the fixed frame can not only disperse the ear pressure, but also reduce the fluctuation amplitude of the mouse corticosterone level by combining the lightweight structure design.

[0021] Secondly, the present application can maintain a constant release rate by expanding the reaction area with time through the spiral-shaped notch arranged on the medicine pill.

[0022] Thirdly, the present application can adapt to mice of different body types through the modular design of the mouth cover and the head fixing sheet, and the adjustable expansion sheet and the auxiliary fixing belt, and the mouth edge ring can position the flow guide, so as to not only reduce the total weight of the equipment, but also avoid the additional burden on the experimental animals. BRIEF DESCRIPTION OF DRAWINGS

[0023] Figure 1 Structure diagram of the mouse wearable micro-injection device in the present application;

[0024] Figure 2 Structure diagram of the fixed frame in the present application;

[0025] Figure 3 Structure diagram of the slow injection device with medicine bin / expansion bag in the present application;

[0026] Figure 4 Structure diagram of the slow injection device with expansion bin in the present application;

[0027] Figure 5 Sectional view of the slow injection device with expansion bag in the present application;

[0028] Figure 6 Sectional view of the slow injection device with medicine bin in the present application;

[0029] Figure 7 Enlarged view of part A in the present application; Figure 6

[0030] Sectional view of the structure in the present application; Figure 8 Figure 4

[0031] Figure 9 Structure diagram of the injection plug in the present application;

[0032] Figure 10 Another structure diagram of the injection plug in the present application;

[0033] Figure 11 Structure diagram of the medicine pill in the present application;

[0034] Figure 12 Structure diagram of the expansion bag in the present application.

[0035] Corresponding number names of each part in the figure:

[0036] ​​1, fixed frame; 101, mouth sleeve; 102, mouth ring; 103, belt piece; 104, head fixing belt; 105, head fixing piece; 106, head adapting port; 107, hanging ear port; 108, expansion piece; 109, auxiliary fixing belt; 2, slow injection device; 201, syringe body; 202, sealing cover; 203, injection plug; 204, liquid injection port; 205, medicine injection port; 206, fixing ear; 207, medicine bin; 208, medicine pill; 209, aluminum foil; 210, expansion bag; 211, partition piece; 212, flow guide strip; 213, expansion bin; 214, medicine body; 215, wax sealing layer; 216, connecting rod; 217, arc-shaped groove; 218, plastic sealing belt; 219, expansion cavity; 220, cotton piece; 221, expansion medicine layer; 222, through hole; 3, flow guide device. DETAILED DESCRIPTION

[0037] The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor fall within the scope of protection of the present application.

[0038] Embodiment 1

[0039] Reference Figures 1-4 The present embodiment provides a mouse wearable micro-injection device for slow release of rhodiolin, which comprises a fixed frame 1, a slow injection device 2 and a flow guide device 3. The fixed frame 1 is fixedly connected to the head of the mouse through the head fixing belt 104, the slow injection device 2 is arranged at the upper end of the fixed frame 1, and the fixed frame 1, the slow injection device 2 and the back of the mouse are fixedly connected through the auxiliary fixing belt 109.

[0040] In the present embodiment, the slow injection device 2 comprises a syringe body 201, wherein the inside of the syringe body 201 is provided with a liquid storage area and a reaction area. Specifically, the upper end of the syringe body 201 is provided with a liquid injection port 204 and a medicine injection port 205 on both sides, which are respectively connected with the reaction area and the liquid storage area. That is, the rhodiolin-glucose mixed solution can be injected into the liquid storage area through the medicine injection port 205, and the reaction liquid can be injected into the reaction area through the liquid injection port 204. It is worth noting that the inside of the liquid injection port 204 and the medicine injection port 205 in the present embodiment is filled with rubber, that is, in the process of use, the corresponding liquid can be injected into the liquid storage area and the reaction area through the needle of the syringe penetrating the rubber, and after the needle of the syringe is pulled out after injection, the airtightness of the liquid storage area and the reaction area can be ensured through the elastic extrusion of the rubber itself.

[0041] Further, the injection plug 203 is arranged between the liquid storage area and the reaction area, and the side of the injection plug 203 is in close contact with the inner wall of the syringe body 201, and one end of the syringe body 201 is connected with the flow guide 3, and the other end is provided with a sealing cover 202. Specifically, the end of the flow guide 3 is connected with the liquid storage area, and the flow guide 3 and the inside of the liquid storage area are in communication, and the other end of the flow guide 3 extends into the mouse mouth.

[0042] Further, the inside of the reaction area is provided with a movable reaction assembly, the sealing cover 202 is arranged on the side of the movable reaction assembly, and the injection plug 203 moves due to the change of the movable reaction assembly and injects the medicine in the liquid storage area to the outside. That is to say, due to the injection of the reaction liquid in the reaction area, the movable reaction assembly changes, thereby driving the injection plug 203 to move to the liquid storage area, so that under the action of the movement of the injection plug 203, the rhodioloside-glucose mixed solution injected in the liquid storage area flows from the inside of the liquid storage area into the flow guide 3, and under the action of the flow guide 3, enters the mouse body through the mouse mouth. Therefore, through the change of the movable reaction assembly, the rhodioloside-glucose mixed solution micro-flow can be adjusted.

[0043] Embodiment 2

[0044] The embodiment provides a mouse wearable micro-injection device for rhodioloside sustained release, and the specific implementation structure is the same as that of embodiment 1, and the difference lies in that the fixed frame 1 comprises a mouth cover 101, a head fixing sheet 105 and a plurality of expansion sheets 108 connected in sequence, and the mouse and the slow injector 2 are connected through the mouth cover 101, the head fixing sheet 105 and the plurality of expansion sheets 108. The application will be illustrated by combining the specific implementation manner of the embodiment.

[0045] Reference Figure 2 In the embodiment, the end of the mouth cover 101 is provided with a penetrating sheet 103, and the two sides of the mouth cover 101 are provided with a mouth edge ring 102. In the embodiment, the two sides of the head fixing sheet 105 are provided with a head adapting opening 106, and the side of the head adapting opening 106 is provided with a hanging ear opening 107, and the hanging ear opening 107 is in close contact with the mouse ear.

[0046] Specifically, in the embodiment, after the mouth cover 101 penetrates the mouse mouth, the penetrating sheet 103 is arranged at the lower end of the mouse mouth, the head fixing sheet 105 is stretched to the back of the mouse ear, and the hanging ear opening 107 is in close contact with the root of the mouse ear, then the two ends of the head fixing band 104 are respectively penetrated through the perforations at the two ends of the penetrating sheet 103, and then the head fixing band 104 is penetrated through the mouse head and the head adapting openings 106 on the two sides of the head fixing sheet 105. At this time, the two ends of the head fixing band 104 penetrating through the head adapting openings 106 are fixed, and the end of the fixed frame 1 is fixed with the mouse head.

[0047] Further, the expansion pieces 108 in the embodiment are provided in plurality, and the number of the expansion pieces 108 can be adjusted according to the actual size of the mouse, and thus the number of the expansion pieces 108 in the embodiment is not specifically limited, and only six expansion pieces 108 are described and illustrated. Meanwhile, the two sides of the syringe body 201 in the embodiment are provided with the fixing ears 206.

[0048] Specifically, after the auxiliary fixing belt 109 is passed through the abdomen of the mouse, the two ends of the auxiliary fixing belt 109 are passed through the perforations on the two sides of any one of the expansion pieces 108, and then the two ends of the auxiliary fixing belt 109 are passed through the fixing ears 206 on the two sides of the syringe body 201, and then the two ends of the auxiliary fixing belt 109 are fixed, so that the syringe body 201 is fixed on the back of the mouse.

[0049] That is, after the syringe body 201 is fixed with the mouse, one end of the flow guide 3 is connected with the liquid outlet of the liquid storage area of the syringe body 201, and the other end of the flow guide 3 is inserted into the mouth of the mouse after passing through the mouth edge ring 102. Thus, the rhodioloside-glucose mixed solution in the liquid storage area can enter the mouse body through the mouse mouth.

[0050] Embodiment 3

[0051] The embodiment provides a mouse wearable micro-injection device for rhodioloside sustained release, and the specific implementation structure is the same as those in Embodiments 1 and 2, and the difference lies in that the active reaction assembly includes but is not limited to the deformable medicine bin 207, the expansion bag 210 and the expansion bin 213, wherein the injection plug 203 can move due to the changes of the medicine bin 207, the expansion bag 210 and the expansion bin 213, so that the rhodioloside-glucose mixed solution in the liquid storage area is sent into the mouse body through the flow guide 3. The application is exemplarily described below in combination with the specific implementation manner of the embodiment.

[0052] Reference Figure 6 and Figure 7 In the embodiment, the deformable medicine bin 207 is exemplarily described and illustrated. In the embodiment, the medicine bin 207 is arranged in the middle of the sealing cover 202, and the medicine bin 207 is arranged in soft body, that is, the medicine bin 207 can be pressed. Meanwhile, the medicine bin 207 is internally provided with the medicine pill 208, the medicine pill 208 is isolated from the reaction area by the aluminum foil 209, and the medicine pill 208 and the injection plug 203 are oppositely arranged. Specifically, the medicine pill 208 can be squeezed to break the aluminum foil 209 by pressing the medicine bin 207, and at this time, the medicine pill 208 will fall into the inside of the reaction area.

[0053] Reference Figure 11The pill 208 in the embodiment includes a medicine body 214, wherein the outer surface of the medicine body 214 is provided with a wax sealing layer 215, and the wax sealing layer 215 is provided with a notch. That is, after the reaction liquid is injected into the reaction area through the injection port 204, the pill 208 falling in the reaction area will react with the reaction liquid through the notch, and the injection plug 203 will move towards the liquid storage area through the reaction between the two, so that the rhodiolin-glucose mixed solution injected into the liquid storage area will flow into the flow guide 3 under the action of the movement of the injection plug 203.

[0054] Further, referring to Figure 10 The injection plug 203 in the embodiment includes a connecting rod 216 and two pistons. The two pistons are connected through the connecting rod 216, and the piston on the side of the liquid storage area is provided with an arc-shaped groove 217 on the outer side, and the middle part of the arc-shaped groove 217 is fitted with the end of the flow guide 3, and the side of the piston on the side of the reaction area is tightly attached to and perpendicular to the inner wall of the syringe body 201. That is, when the injection plug 203 is driven to move by the reaction between the medicine body 214 and the reaction liquid, the injection plug 203 is not easy to tilt due to the linkage action of the two pistons. At the same time, the setting of the arc-shaped groove 217 can make the rhodiolin-glucose mixed solution in the liquid storage area better transmit outward during injection, thereby reducing the residual amount in the liquid storage area.

[0055] In the embodiment, when the pill 208 is set as a sodium bicarbonate pill, dilute acetic acid solution can be injected into the reaction area. Since the wax sealing layer 215 is provided with a spiral notch, the sodium bicarbonate pill will fall into the dilute acetic acid solution after the aluminum foil 209 is broken by pressing the pill chamber 207. At the same time, due to the setting of the spiral notch, the sodium bicarbonate pill and the dilute acetic acid solution will react initially through the notch, and as the reaction proceeds, the wax sealing layer 215 attached to the outside of the sodium bicarbonate pill will continuously diffuse, at which time the notch will continuously expand, so that although the amount of the sodium bicarbonate pill decreases as the reaction proceeds, the reaction area continuously expands as the reaction proceeds, thereby ensuring the stability of the reaction rate. That is, the CO2 gas generated by the reaction between the sodium bicarbonate pill and the dilute acetic acid solution can increase the pressure in the reaction area, so that the injection plug 203 can move towards the liquid storage area under the action of the pressure difference.

[0056] Specifically, after the needle of the syringe penetrates the rubber in the injection port 205, the salidroside-glucose mixture can be injected into the inside of the storage area, and the inside of the storage area needs to reserve 5% of the redundant space. After the rubber in the injection port 204 is pulled out, the dilute acetic acid solution is injected into the reaction area through the syringe until the injection volume reaches 80% of the volume of the reaction area. Then, the whole buffer injection device 2 is tilted so that the gas in the reaction area can be discharged from the injection port 204, and then the remaining space in the reaction area is injected with the dilute acetic acid solution. Finally, the rubber at the injection port 204 is filled to keep the reaction area sealed, and then the cartridge 207 is pressed so that the sodium bicarbonate pill can react with the dilute acetic acid solution.

[0057] Further, when the pill 208 is set as a calcium carbonate pill, 0.5M dilute hydrochloric acid can be injected into the reaction area. Similarly, the reaction between the calcium carbonate pill and the 0.5M dilute hydrochloric acid is the same as the reaction between the sodium bicarbonate pill and the dilute acetic acid solution. The CO2 gas generated between the two can increase the pressure inside the reaction area, so that the injection plug 203 can move to the storage area under the action of the pressure difference.

[0058] Embodiment 4

[0059] The embodiment provides a mouse wearable micro-injection device for salidroside sustained release. The specific implementation structure is the same as that of the embodiments 1 and 2, and the difference lies in that the movable reaction assembly in the embodiment is set as an expansion bag 210. The embodiment is exemplified in combination with the specific implementation manner of the embodiment.

[0060] Reference Figure 5 and Figure 12 The expansion bag 210 is arranged on the side of the injection plug 203 facing the reaction area. Specifically, the expansion bag 210 comprises an expansion cavity 219, a plurality of expansion pill layers 221 and a plastic sealing strip 218. The expansion cavity 219 and the plurality of expansion pill layers 221 are arranged in the inside of the plastic sealing strip 218, and the expansion cavity 219 and the expansion pill layers 221 and the adjacent two expansion pill layers 221 are spaced by the cotton sheet 220. It is worth noting that the number of the expansion pill layers 221 in the embodiment can be set according to the actual size of the reaction area, and three expansion pill layers 221 are arranged in the embodiment.

[0061] Further, a plurality of through holes 222 are formed in the end of the plastic sealing strip 218 close to the expansion pill layers 221, the plurality of through holes 222 are uniformly formed in the end of the plastic sealing strip 218, and the plurality of through holes 222 are in communication with the inside of the reaction area. That is, the expansion pill layers 221 can be in communication with the inside of the reaction area through the through holes 222.

[0062] Further, reference Figure 10The injection plug 203 in the embodiment comprises a connecting rod 216 and two pistons. The two pistons are connected by the connecting rod 216, and the piston facing the liquid storage area has an arc-shaped groove 217 on the outward side, while the middle part of the arc-shaped groove 217 is in contact with the end of the flow guide 3. The side of the piston facing the reaction area is in close contact with and perpendicular to the inner wall of the syringe body 201. That is, when the injection plug 203 is moved by the reaction between the drug body 214 and the reaction liquid, the two pistons are linked, so that the injection plug 203 is not prone to tilting during movement. The arrangement of the arc-shaped groove 217 can make the salidrosides-glucose mixture in the liquid storage area better transported outward during injection, thereby reducing the residual amount in the liquid storage area.

[0063] Specifically, after the reaction liquid is injected into the reaction area through the liquid injection port 204, the reaction liquid will enter the inside of the expansion drug layer 221 through the plurality of through holes 222, so that the expansion drug layer 221 expands. When the first layer of expansion drug layer 221 expands to the limit, the reaction liquid will pass through the cotton sheet 220 and enter the second layer of expansion drug layer 221, so that the second layer of expansion drug layer 221 expands, until all three layers of expansion drug layer 221 expand to the limit. It is worth noting that due to the slow expansion rate, the injection plug 203 will slowly move to the liquid storage area during expansion.

[0064] In the embodiment, the inside of the expansion drug layer 221 is filled with sodium polyacrylate particles, and physiological saline can be injected into the reaction area. Specifically, the sodium polyacrylate particles can expand by 9-10 times in volume after absorbing water through the through holes 222, so as to sequentially expand the cotton sheets 220. That is, the expansion force generated by the sodium polyacrylate particles after absorbing water can be transmitted to the side of the arc-shaped groove 217 through the expansion cavity 219, so as to move the injection plug 203 to the liquid storage area.

[0065] Specifically, after the needle of the syringe penetrates the rubber in the drug injection port 205, the salidrosides-glucose mixture can be injected into the inside of the liquid storage area, and 5% of redundant space needs to be reserved in the inside of the liquid storage area. After the rubber in the liquid injection port 204 is pulled out, physiological saline is injected into the reaction area through the syringe, and the physiological saline is injected in multiple times with intervals during the injection, so that the gas in the reaction area can be discharged in time, and finally the rubber at the liquid injection port 204 is filled.

[0066] Further, the inside of the expansion drug layer 221 can also be filled with polyacrylamide copolymer, potassium polyacrylate and sodium polyacrylate, and different substances can be sequentially filled in different expansion drug layers 221 to form an expansion gradient, so as to move the injection plug 203 to the liquid storage area.

[0067] Specifically, in this embodiment, polyacrylamide copolymer, potassium polyacrylate and sodium polyacrylate are filled in the three expansion layers 221 respectively. Therefore, when the reaction liquid is injected into the reaction area, the rubber in the injection port 204 is pulled out, 5% NaCl solution is first injected into the reaction area to wet the first layer of the expansion layer 221, and after 10 minutes of waiting and exhausting, 0.9% physiological saline is injected into the reaction area to wet the second layer of the expansion layer 221, and after exhausting again, distilled water is injected into the reaction area to wet all the expansion layers 221 to make them expand. It is worth noting that after each injection of the reaction liquid, the outer wall of the syringe body 201 can be flicked to promote the rising of the bubbles in the reaction area, thereby accelerating the exhausting rate of the reaction area.

[0068] Embodiment 5

[0069] The present embodiment provides a mouse wearable micro-injection device for the sustained release of rhodiolin, which has the same specific implementation structure as Embodiments 1 and 2, except that the movable reaction assembly in the present embodiment is provided as an expansion bin 213. The present application is illustrated below in conjunction with the specific implementation of the present embodiment.

[0070] Reference Figure 8 The expansion bin 213 is arranged on one side of the injection plug 203, wherein the inside of the expansion bin 213 is filled with solid expansion material and a flow guide strip 212, and the expansion bin 213 and the reaction area are spaced apart by a spacer 211, and the end of the flow guide strip 212 penetrates the spacer 211 and is connected to the inside of the reaction area. It is worth noting that the flow guide strip 212 arranged in the expansion bin 213 is provided with redundancy, and the end of the flow guide strip 212 is connected to the side of the injection plug 203 in a wavy manner. That is, after the reaction liquid is injected into the inside of the reaction area through the injection port 204, the reaction liquid will be guided into the inside of the expansion bin 213 through the flow guide strip 212 of the reaction area, and will react with the solid expansion material in the inside of the expansion bin 213, so that the solid expansion material will expand, and under the expansion action of the solid expansion material, the injection plug 203 will move towards the liquid storage area, and then the rhodiolin-glucose mixed solution injected into the inside of the liquid storage area will flow into the flow guide 3 from the inside of the liquid storage area.

[0071] Reference Figure 9 The injection plug 203 in the present embodiment includes a connecting rod 216 and two pistons. The two pistons are connected by the connecting rod 216, and the side surfaces of the pistons are tightly and perpendicularly arranged between the inner wall of the syringe body 201. That is, when the injection plug 203 is moved by the reaction between the solid expansion material and the reaction liquid, the injection plug 203 is not easy to tilt due to the linkage action of the two pistons.

[0072] In the present embodiment, the solid expansion material includes, but is not limited to, acrylic-acrylamide copolymer particles, sodium bicarbonate solid and sodium polyacrylate composite. Specifically, when the solid expansion material is acrylic-acrylamide copolymer particles, normal saline can be injected into the reaction zone. That is, after the acrylic-acrylamide copolymer particles are wetted by the capillary action of the flow guide strip 212, the acrylic-acrylamide copolymer particles will expand and push the injection plug 203 to move towards the liquid storage zone in the process of expansion. It is worth noting that the volume of the expansion chamber 213 should be 1.2 times that of the liquid storage zone to ensure that it can be completely emptied. That is, the volume of the reaction zone in which the cartridge 207 / expansion bag 210 is arranged inside is smaller than the volume of the reaction zone in which the expansion chamber 213 is arranged inside.

[0073] Further, the inside of the expansion chamber 213 can also be layered with sodium bicarbonate solid and sodium polyacrylate, and an acidic reaction liquid can be injected into the reaction zone. That is, after the acidic reaction liquid and the sodium bicarbonate solid are initially reacted by the capillary action of the flow guide strip 212 to generate an initial thrust, the sodium polyacrylate will further react and generate a subsequent thrust in the process of the reaction, so as to ensure that the injection plug 203 moves stably towards the liquid storage zone.

[0074] It is worth noting that the reaction zone in the present embodiment is inside the expansion chamber 213, so when the reaction liquid is injected into the inside of the reaction zone through the liquid injection port 204, the rubber at the liquid injection port 204 does not need to be pulled out, and the needle of the syringe can directly penetrate the rubber inside the liquid injection port 204 to inject the reaction liquid into the reaction zone.

[0075] Although the embodiments of the present application have been shown and described, it is understood that various changes, modifications, substitutions and variations can be made to these embodiments without departing from the principles and spirit of the present application, and the scope of the present application is defined by the appended claims and their equivalents.

Claims

1. A mouse-worn micro-injection device for sustained release of rhodioloside, comprising a frame (1), a slow-release injector (2) disposed at the upper end of the frame (1), and a flow guide (3) connected to the slow-release injector (2), characterized in that: The slow-injector (2) includes a syringe body (201) with a reservoir and a reaction zone inside. An injection plug (203) is provided between the reservoir and the reaction zone. The side of the injection plug (203) is in contact with the inner wall of the syringe body (201), and the flow guide (3) is connected to the reservoir. The syringe body (201) has an injection port (204) connected to the reaction zone and a drug injection port (205) connected to the reservoir zone on both sides of its upper end. The injection port (204) and the drug injection port (205) are filled with rubber. One end of the syringe body (201) is connected to the flow guide (3), and the other end is provided with a sealing cap (202). The reaction zone is provided with a movable reaction component. The sealing cap (202) is located on the side of the movable reaction component. The injection plug (203) moves due to the change of the movable reaction component and injects the drug in the reservoir zone to the outside. The fixing frame (1) includes a mouthpiece (101), a head fixing piece (105) and a plurality of extension pieces (108) connected in sequence. The strap piece (103) at the end of the mouthpiece (101) and the head adapter port (106) on both sides of the head fixing piece (105) are fixedly connected by a head fixing strap (104). The fixing ears (206) on both sides of the syringe body (201) and the extension pieces (108) are fixedly connected by an auxiliary fixing strap (109). The mouth cover (101) has mouth rings (102) on both sides, the end of the flow guide (3) passes through the mouth rings (102), and the ear hook (107) located on the side of the head adapter (106) fits into the mouse's ear. The active reaction component includes a deformable drug container (207), an expansion pack (210), or an expansion chamber (213), and the injection plug (203) moves due to the changes in the drug container (207), the expansion pack (210), or the expansion chamber (213). The volume of the reaction zone with the drug container (207) or the expansion pack (210) inside is smaller than the volume of the reaction zone with the expansion chamber (213) inside. The expansion chamber (213) located on one side of the injection plug (203) is filled with solid expansion material and a guide strip (212). The expansion chamber (213) and the reaction zone are separated by a partition (211), and the end of the guide strip (212) passes through the partition (211) and is connected to the interior of the reaction zone.

2. The mouse-worn micro-injection device for sustained release of rhodioloside according to claim 1, characterized in that: A pill (208) is disposed inside the medicine chamber (207) located in the middle of the sealing cover (202). The pill (208) is isolated from the reaction zone by aluminum foil (209). The pill (208) and the injection plug (203) are arranged opposite to each other. At the same time, the pill (208) falls into the interior of the reaction zone by pressing the medicine chamber (207) and breaking the aluminum foil (209).

3. The mouse-worn micro-injection device for sustained release of rhodioloside according to claim 2, characterized in that: The pill (208) includes a pill body (214), the outer surface of which is provided with a wax seal layer (215), and the wax seal layer (215) is provided with a notch, through which the pill body (214) contacts the interior of the reaction zone.

4. The mouse-worn micro-injection device for sustained release of rhodioloside according to claim 1, characterized in that: The expansion pack (210) located on the side of the injection plug (203) facing the reaction zone includes an expansion cavity (219), multiple expansion drug layers (221), and a sealing strip (218). The expansion cavity (219) and multiple expansion drug layers (221) are all located inside the sealing strip (218), and the expansion cavity (219) and expansion drug layers (221), as well as two adjacent expansion drug layers (221), are spaced apart by cotton pads (220). The sealing tape (218) has multiple through holes (222) at one end near the expanded drug layer (221), and the expanded drug layer (221) is connected to the interior of the reaction zone through the through holes (222).

5. A mouse-worn micro-injection device for sustained release of rhodioloside according to claim 2 or 4, characterized in that: The injection plug (203) includes two pistons connected by a connecting rod (216), and an arc groove (217) is provided on the outward side of the piston facing the liquid storage area. At the same time, the middle part of the arc groove (217) is in contact with the end of the guide (3), and the side of the piston facing the reaction area is in close contact with and perpendicular to the inner wall of the syringe body (201).

6. The mouse-worn micro-injection device for sustained release of rhodioloside according to claim 1, characterized in that: The guide strip (212) provided inside the expansion chamber (213) is redundant, and the end of the guide strip (212) is wavy and connected to the side of the injection plug (203).

7. A mouse-worn micro-injection device for sustained release of rhodioloside according to claim 1 or 6, characterized in that: The injection plug (203) includes two pistons connected by a connecting rod (216), and the sides of the pistons are in close contact with and perpendicular to the inner wall of the syringe body (201).

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