Traditional Chinese medicine composition for treating arrhythmia and preparation method thereof

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating arrhythmia and a preparation method thereof. The traditional Chinese medicine composition for treating arrhythmia comprises the following components according to monarch, minister, assistant and guide: coptis chinensis for purging fire for removing toxin, clearing away the heart-fire and drying dampness, nacre for soothing the nerves and arresting convulsion, and coptis chinensis and nacre are combined for regulating qi for arresting palpitation, removing toxin and activating blood. The Chinese angelica, the dried orange peel and the rhodiola rosea are combined to enhance the effects of promoting qi circulation, promoting blood circulation and removing blood stasis. Salvia miltiorrhiza, sandalwood, fructus amomi, polygala tenuifolia and fructus forsythiae are combined to strengthen spleen and stomach, clear away the heart-fire and traffic heart and kidney, and are used as adjuvant drugs. The traditional Chinese medicine is prepared according to a certain weight ratio, treats both symptoms and root causes, treats deficiency and excess simultaneously, has the effects of regulating qi, relieving palpitation, detoxifying and activating blood, and realizes the treatment effect on arrhythmia.

Description

Technical Field

[0001] The present invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine composition for treating arrhythmia and a preparation method thereof. Background Art

[0002] The Suwen (Suwen) chapter on "Discussion on Pain" provides a preliminary description of palpitations: "When frightened, the heart has no support, the spirit has no place to return, and the mind has no peace of mind." Palpitations first appear as a disease name in the Treatise on Febrile Diseases and Miscellaneous Diseases, referring to them as "palpitations below the heart," "palpitations in the heart," and "palpitations caused by shock." The Jisheng Fang (Jisheng Fang) further defines its severe clinical manifestations as "palpitations." Clinically, patients with palpitations experience a violent heartbeat, a sense of restlessness, and even inability to control their movements. These symptoms often occur after emotional excitement or exertion, and are often accompanied by chest tightness, shortness of breath, insomnia, and dizziness.

[0003] Heart palpitations are equivalent to arrhythmias in modern medicine, including bradycardia, tachycardia, premature ventricular contractions, atrial fibrillation, sick sinus syndrome, atrioventricular block, etc.

[0004] Arrhythmia is an abnormality of cardiac activity, characterized by changes in heart rhythm caused by abnormalities in the origin or conduction of cardiac impulses. Mild cases of arrhythmia may present with no obvious symptoms, while severe cases may experience palpitations, chest tightness, shortness of breath, fatigue, and sweating. Severe cases may lead to dizziness, fainting, suffocation, and even life-threatening conditions. Arrhythmias can be caused by a variety of factors, including genetic susceptibility, insufficient internal energy, external environmental stimulation, or other organic disorders.

[0005] Currently, research on the treatment of arrhythmias is ongoing, with both pharmacological and non-drug therapies, or a combination of both, being used clinically. Pharmacological treatments generally include: Class I sodium channel blockers, such as propafenone; Class II β-adrenergic receptor antagonists, such as metoprolol; and Class III potassium channel blockers, such as amiodarone. Clinically, with the exception of severe, life-threatening arrhythmias, such as ventricular fibrillation, ventricular flutter, malignant ventricular tachycardia, and various arrhythmias associated with acute heart failure, which require active Western medical rescue measures, most arrhythmias can be treated with Traditional Chinese Medicine (TCM). TCM also offers a low incidence of adverse reactions, is less likely to recur after discontinuation, and offers numerous advantages over Western medicine in the treatment of arrhythmias. Summary of the Invention

[0006] The purpose of the present invention is to provide a safe, effective and low-adverse-reaction Chinese medicinal composition for treating arrhythmia and a preparation method thereof.

[0007] The invention provides a traditional Chinese medicine composition for treating arrhythmia. The traditional Chinese medicine composition is prepared from coptis root, mother of pearl, angelica root, tangerine peel, rhodiola rosea, salvia miltiorrhiza, santalinum officinale, amomum villosum, polygala tenuifolia and forsythia suspensa.

[0008] Furthermore, the traditional Chinese medicine composition for treating arrhythmia is prepared from the following raw materials: 15-25 parts of coptis chinensis, 15-25 parts of mother-of-pearl, 15-25 parts of angelica sinensis, 10-20 parts of tangerine peel, 10-20 parts of rhodiola rosea, 10-20 parts of salvia miltiorrhiza, 10-20 parts of santalinum, 5-12 parts of amomum villosum, 5-12 parts of polygala tenuifolia and 5-12 parts of forsythia suspensa.

[0009] Furthermore, the Chinese medicine composition for treating arrhythmia includes the following raw materials in parts by weight: 20 parts of coptis chinensis, 20 parts of mother-of-pearl, 20 parts of angelica sinensis, 15 parts of tangerine peel, 15 parts of rhodiola rosea, 15 parts of salvia miltiorrhiza, 15 parts of santalinum, 9 parts of amomum villosum, 9 parts of polygala tenuifolia and 9 parts of forsythia suspensa.

[0010] Furthermore, the Chinese medicine composition for treating arrhythmia includes the following raw materials in parts by weight: 20 parts of Coptis chinensis, 15 parts of mother-of-pearl, 20 parts of Angelica sinensis, 10 parts of dried tangerine peel, 10 parts of Rhodiola rosea, 20 parts of Salvia miltiorrhiza, 20 parts of Santalum album, 10 parts of Amomum villosum, 10 parts of Polygala tenuifolia and 9 parts of Forsythia suspensa.

[0011] Furthermore, the Chinese medicine composition for treating arrhythmia includes the following raw materials in parts by weight: 25 parts of coptis chinensis, 20 parts of mother-of-pearl, 15 parts of angelica sinensis, 20 parts of dried tangerine peel, 15 parts of rhodiola rosea, 10 parts of salvia miltiorrhiza, 20 parts of santalin, 12 parts of amomum villosum, 9 parts of polygala tenuifolia and 9 parts of forsythia suspensa.

[0012] The preparation method of the traditional Chinese medicine composition for treating arrhythmia is as follows: weighing various medicinal materials, mixing, soaking in water, decocting, filtering, and combining the filtrate to obtain a decoction.

[0013] Furthermore, the preparation method of the present invention is as follows: weigh each medicinal material, soak for 30-50 minutes, decoct twice, add 10 times the amount of water each time, decoct for 60-90 minutes each time, concentrate the filtrate, and combine the filtrate to obtain a decoction.

[0014] The preparation of the traditional Chinese medicine composition for treating arrhythmia of the present invention is decoction, pill, gel, tablet, mixture, capsule, granule, powder or paste.

[0015] Furthermore, the preparation of the traditional Chinese medicine composition for treating arrhythmia is a decoction.

[0016] The present invention provides use of the traditional Chinese medicine composition for treating arrhythmia in preparing a medicine for preventing or treating arrhythmia.

[0017] The pharmacological effects of the raw materials in the Chinese medicine composition for treating arrhythmia of the present invention are as follows:

[0018] Coptis chinensis: bitter in taste, cold in nature, enters the heart, spleen, stomach, liver, gallbladder, and large intestine meridians, clears away heat and dampness, purges fire and detoxifies; used for damp-heat fullness, vomiting and acid regurgitation, diarrhea, jaundice, high fever and coma, hyperactivity of heart fire, restlessness and insomnia, vomiting and epistaxis due to blood heat, red eyes, toothache, diabetes, carbuncles and furuncles.

[0019] Mother of pearl: salty in taste, cold in nature, enters the liver and heart meridians, calms the liver and suppresses yang, calms the mind and relieves convulsions, and removes cataracts; used for headaches, dizziness, palpitations, insomnia, red eyes, cataracts, and blurred vision.

[0020] Angelica: spicy and bitter in taste, warm in nature, enters the liver, heart and spleen meridians, replenishes blood and promotes blood circulation, regulates menstruation and relieves pain, moistens the intestines and promotes bowel movements; used for blood deficiency and sallow complexion, dizziness and palpitations, irregular menstruation, amenorrhea and dysmenorrhea, abdominal pain due to deficiency and cold, dry intestines and constipation, rheumatic pain, injuries from falls, carbuncles and ulcers.

[0021] Tangerine peel: It tastes spicy and bitter, is warm in nature, and enters the spleen meridian, stomach meridian, and lung meridian. It can regulate qi and strengthen the spleen, regulate the middle, dry up dampness, and resolve phlegm. It is used for abdominal distension or pain and indigestion caused by spleen and stomach qi stagnation.

[0022] Rhodiola rosea: sweet and astringent in taste, cold in nature, enters the lung meridian, promotes blood circulation and stops bleeding, clears the lungs and relieves cough; treats hemoptysis, hemoptysis, pneumonia cough, and leucorrhea in women; used externally to treat bruises, burns, and scalds.

[0023] Salvia miltiorrhiza: bitter in taste, slightly cold in nature, enters the heart and liver meridians, removes blood stasis and relieves pain, promotes blood circulation and dredges menstruation, clears the heart and relieves restlessness; used for irregular menstruation, amenorrhea, dysmenorrhea, accumulation of masses, stabbing pain in the chest and abdomen, pain due to heat rheumatic arthritis, swollen and painful sores, restlessness and insomnia; hepatosplenomegaly, and angina pectoris.

[0024] Sandalwood: spicy and warm in nature, it enters the spleen, stomach, heart and lung meridians, promotes qi and warms the middle, stimulates appetite and relieves pain; it is used to treat cold stagnation of qi, chest discomfort and other symptoms.

[0025] Amomum villosum: spicy in taste, warm in nature, enters the spleen, stomach, and kidney meridians, eliminates dampness and stimulates appetite, warms the spleen and stops diarrhea, regulates qi and stabilizes the fetus; used for dampness and turbidity blocking the middle part of the body, abdominal distension without hunger, spleen and stomach deficiency and cold, vomiting and diarrhea, nausea and vomiting during pregnancy, and fetal movement disorder.

[0026] Polygala: bitter and pungent in taste, warm in nature, enters the heart, kidney and lung meridians, calms the mind and improves intelligence; used for palpitations, insomnia, forgetfulness and nightmares, expectoration and invigoration, cough with phlegm, chest tightness, swelling and pain relief, carbuncle, swelling and poison, bruises, etc.

[0027] Forsythia: bitter in taste, cool in nature, enters the heart, liver, and gallbladder meridians, clears heat, detoxifies, disperses stagnation, and reduces swelling; used for febrile diseases, erysipelas, rashes, carbuncles, swelling, scrofula, and stranguria.

[0028] The formula of the Chinese medicine of the present invention is as follows:

[0029] The core pathogenesis of palpitations lies in weak Zhongqi, leading to disharmony between the heart and kidneys, resulting in excessive heat and fire in the upper body, and disturbing the mind. Therefore, the root cause of palpitations is the abnormal transformation of Zhongqi in the spleen and stomach. Furthermore, arrhythmias are primarily due to deficiency of Qi and blood, and yin and yang deficits; the symptoms are qi stagnation, blood stasis, turbid phlegm, and water retention. Treatments include pungent dispersing herbs to dispel wind, calming the liver to extinguish wind, detoxifying to dispel wind, activating blood circulation to dispel wind, nourishing blood to dispel wind, and clearing the meridians to dispel wind.

[0030] The traditional Chinese medicine composition for treating arrhythmias of the present invention is formulated according to the principles of monarch, minister, adjuvant, and guiding: Coptis chinensis clears heat and detoxifies, clears the heart and dries dampness, while mother-of-pearl calms the mind and calms the nerves. The combination of the two promotes qi and calms palpitations, detoxifies, and promotes blood circulation. Angelica sinensis replenishes blood and promotes blood circulation, dried tangerine peel regulates qi and strengthens the spleen, and rhodiola rosea promotes blood circulation and stops bleeding. The combination of the three enhances the efficacy of promoting qi, activating blood circulation, and removing blood stasis. Salvia miltiorrhiza, Santalum album, Amomum villosum, Polygala tenuifolia, and Forsythia suspensa together invigorate the spleen and stomach, clear the heart and purge heat, and connect the heart and kidneys, serving as adjuvant and guiding ingredients. The entire formula is formulated according to specific weight ratios, treating both the symptoms and the root cause, addressing both deficiency and excess, and achieving the effects of regulating qi and calming palpitations, detoxifying, and promoting blood circulation, thereby achieving a therapeutic effect on arrhythmias.

[0031] Compared with the prior art, the present invention has the following advantages:

[0032] The Chinese herbal composition of the present invention significantly delays the onset of arrhythmias, shortens their duration, and reduces the incidence of VT and VF, combating myocardial ischemia-reperfusion arrhythmias and demonstrating a promising therapeutic effect. Comparative results indicate that the addition of coptis root, mother-of-pearl, angelica root, dried tangerine peel, and salvia miltiorrhiza has a key impact on the anti-arrhythmic effect, demonstrating that the synergistic effects of the medicinal ingredients in the Chinese herbal composition achieve a therapeutic effect for arrhythmias. BRIEF DESCRIPTION OF THE DRAWINGS

[0033] Figure 1 Comparison of VT incidence in each group.

[0034] Figure 2 Comparison of VF incidence among the groups. DETAILED DESCRIPTION

[0035] The following is a clear and complete description of the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making any creative efforts are within the scope of protection of the present invention.

[0036] Example 1

[0037] A traditional Chinese medicine composition for preventing or treating arrhythmia is prepared from the following raw materials: 20 parts of coptis root, 20 parts of mother-of-pearl, 20 parts of angelica, 15 parts of dried tangerine peel, 15 parts of rhodiola rosea, 15 parts of salvia miltiorrhiza, 15 parts of santalin, 9 parts of amomum villosum, 9 parts of polygala tenuifolia and 9 parts of forsythia.

[0038] Weigh each medicinal material, soak for 50 minutes, decoct twice, add 10 times the amount of water each time, decoct for 90 minutes each time, concentrate the filtrate, and combine the filtrate to obtain the decoction.

[0039] Example 2

[0040] A traditional Chinese medicine composition for preventing or treating arrhythmia is prepared from the following raw materials: 20 parts of coptis root, 15 parts of mother-of-pearl, 20 parts of angelica root, 10 parts of dried tangerine peel, 10 parts of rhodiola rosea, 20 parts of salvia miltiorrhiza, 20 parts of santalin, 10 parts of amomum villosum, 10 parts of polygala tenuifolia and 9 parts of forsythia.

[0041] Weigh each medicinal material, soak for 35 minutes, decoct twice, add 10 times the amount of water each time, decoct for 90 minutes each time, concentrate the filtrate, and combine the filtrate to obtain the decoction.

[0042] Example 3

[0043] A traditional Chinese medicine composition for preventing or treating arrhythmia is prepared from the following raw materials: 25 parts of coptis chinensis, 20 parts of mother-of-pearl, 15 parts of angelica sinensis, 20 parts of dried tangerine peel, 15 parts of rhodiola rosea, 10 parts of salvia miltiorrhiza, 20 parts of santalin, 12 parts of amomum villosum, 9 parts of polygala tenuifolia and 9 parts of forsythia suspensa.

[0044] Weigh each medicinal material, soak for 35 minutes, decoct twice, add 10 times the amount of water each time, decoct for 70 minutes each time, concentrate the filtrate, and combine the filtrate to obtain the decoction.

[0045] Example 4

[0046] A traditional Chinese medicine composition for preventing or treating arrhythmia is prepared from the following raw materials: 25 parts of coptis chinensis, 25 parts of mother-of-pearl, 25 parts of angelica sinensis, 10 parts of dried tangerine peel, 20 parts of rhodiola rosea, 10 parts of salvia miltiorrhiza, 20 parts of santalin, 5 parts of amomum villosum, 12 parts of polygala tenuifolia and 5 parts of forsythia suspensa.

[0047] Weigh each medicinal material, soak for 40 minutes, decoct twice, add 10 times the amount of water each time, decoct for 60 minutes each time, concentrate the filtrate, and combine the filtrate to obtain the decoction.

[0048] Example 5

[0049] A traditional Chinese medicine composition for preventing or treating arrhythmia is prepared from the following raw materials: 15 parts of coptis chinensis, 25 parts of mother-of-pearl, 15 parts of angelica sinensis, 20 parts of dried tangerine peel, 10 parts of rhodiola rosea, 20 parts of salvia miltiorrhiza, 10 parts of santalin, 12 parts of amomum villosum, 5 parts of polygala tenuifolia, and 12 parts of forsythia suspensa.

[0050] Weigh each medicinal material, soak for 50 minutes, decoct twice, add 10 times the amount of water each time, decoct for 80 minutes each time, concentrate the filtrate, and combine the filtrate to obtain the decoction.

[0051] Example 6

[0052] A traditional Chinese medicine composition for preventing or treating arrhythmia is prepared from the following raw materials: 15 parts of coptis chinensis, 20 parts of mother-of-pearl, 20 parts of angelica sinensis, 20 parts of dried tangerine peel, 10 parts of rhodiola rosea, 15 parts of salvia miltiorrhiza, 15 parts of santalin, 8 parts of amomum villosum, 10 parts of polygala tenuifolia and 10 parts of forsythia.

[0053] Weigh each medicinal material, soak for 35 minutes, decoct twice, add 10 times the amount of water each time, decoct for 70 minutes each time, concentrate the filtrate, and combine the filtrate to obtain the decoction.

[0054] Comparative Example 1

[0055] Liangui Ningxin Decoction: It is composed of 15 parts of Coptis chinensis, 12 parts of Ophiopogon japonicus, 15 parts of Pueraria lobata, 10 parts of Tangerine peel, 9 parts of Pinellia ternata, 15 parts of Poria cocos, 3 parts of cinnamon bark, 12 parts of Corydalis yanhusuo, and 10 parts of Licorice root.

[0056] Weigh each medicinal material, soak for 50 minutes, decoct twice, add 10 times the amount of water each time, decoct for 90 minutes each time, concentrate the filtrate, and combine the filtrate to obtain the decoction.

[0057] Comparative Example 2

[0058] 20 parts of Chinese Angelicae Sinensis, 15 parts of dried tangerine peel, 15 parts of Rhodiola Rosea, 15 parts of Salvia miltiorrhiza, 15 parts of Santalum album, 9 parts of Amomum villosum, 9 parts of Polygala tenuifolia and 9 parts of Forsythia suspensa.

[0059] Compared with Example 1, the difference is that Rhizoma Coptidis and Mother of Pearl are not contained, and the other components and amounts remain unchanged.

[0060] The preparation method is the same as that of Example 1.

[0061] Comparative Example 3

[0062] 20 parts of Coptis chinensis, 20 parts of Mother of Pearl, 15 parts of Rhodiola rosea, 15 parts of Salvia miltiorrhiza, 15 parts of Santalum album, 9 parts of Amomum villosum, 9 parts of Polygala tenuifolia and 9 parts of Forsythia suspensa.

[0063] Compared with Example 1, the difference is that angelica and dried tangerine peel are not contained, and other components and usage remain unchanged.

[0064] The preparation method is the same as that of Example 1.

[0065] Comparative Example 4

[0066] 20 parts of Scutellaria baicalensis, 20 parts of mother-of-pearl, 20 parts of Chinese angelica, 15 parts of dried tangerine peel, 15 parts of rhodiola rosea, 15 parts of ligusticum chuanxiong, 15 parts of santalinum, 9 parts of amomum, 9 parts of polygala tenuifolia and 9 parts of forsythia.

[0067] Compared with Example 1, the difference is that Scutellaria baicalensis is used instead of Coptis chinensis, and Ligusticum chuanxiong is used instead of Salvia miltiorrhiza, and the other components and amounts remain unchanged.

[0068] The preparation method is the same as that of Example 1.

[0069] Experimental study on the effect of the Chinese medicine composition of the present invention on myocardial ischemia-reperfusion arrhythmia

[0070] 1. Establishment of arrhythmia rat model

[0071] 42 Wistar rats, weighing 180-220 g, were randomly divided into 7 groups according to their weight, with 6 rats in each group, namely model control group, Example 1 group, Example 2 group, Comparative Example 1 group, Comparative Example 2 group, Comparative Example 3 group, and Comparative Example 4 group.

[0072] The Example 1 group was gavaged with 17.6 g / kg of the Example 1 decoction. The Example 2 group was gavaged with 17.6 g / kg of the Example 2 decoction. The Comparative Example 1 group was gavaged with 17.6 g / kg of the Comparative Example 1 decoction. The Comparative Example 2 group was gavaged with 17.6 g / kg of the Comparative Example 2 decoction. The Comparative Example 3 group was gavaged with 17.6 g / kg of the Comparative Example 3 decoction. The Comparative Example 4 group was gavaged with 17.6 g / kg of the Comparative Example 4 decoction. The dosage for each group was calculated based on the amount of the raw medicinal material. The model control group rats were gavaged with an equal volume of normal saline at a dose of 10 mL / kg. Each group was pre-gavaged for 14 days and then dosed once daily. One hour after the last dose, the rats in each group were lightly anesthetized with an intraperitoneal injection of 25% urethane. Needle electrodes were inserted subcutaneously into the limbs, and standard limb II lead electrocardiograms were observed and recorded. The patients were tracheotomized and artificial respiration was performed with a ventilator at a respiratory rate of 80 times / min. The heart was exposed by thoracotomy. A ligature was made through the superficial myocardium with a needle and suture about 1 mm below the lower edge of the left atrial appendage. The ligature was stabilized for 10 minutes before experimental treatment.

[0073] A 3mm wide rubber strip was placed between the threads of the rats, and the left anterior descending branch of the coronary artery was ligated with a double slipknot. Myocardial ischemia was indicated by a significant elevation of the T segment on the electrocardiogram and darkening of the myocardium below the ligature. The ligature was released after 30 minutes of ischemia, and reperfusion was resumed for 120 minutes.

[0074] 2. Index detection

[0075] During reperfusion, standard limb II lead electrocardiogram was used for continuous monitoring, and the incidence of ventricular tachycardia (VT) and ventricular fibrillation (VF) and the duration of arrhythmia were recorded in each group within 30 minutes.

[0076] 3. Statistical methods

[0077] Graphpad Prism 7.0 software was used for data processing, and the measured data were expressed as mean ± standard deviation (- ) indicated that multiple groups were compared using one-way analysis of variance, and group comparisons were performed using SNK-q. P < 0.05 was considered statistically significant.

[0078] 4. Experimental Results

[0079] The model control group developed severe arrhythmia very quickly, while the onset of arrhythmia in the Example 1 and Example 2 groups was significantly delayed, and the duration of arrhythmia was significantly shortened.

[0080] Compared with the comparative example groups 1-4, the example 1 group had significant differences in delaying the onset of arrhythmia and shortening the duration of arrhythmia. The results are shown in Tables 1 and 2.

[0081] Table 1 Comparison of arrhythmia occurrence time in each group

[0082]

[0083] Note: Compared with the model control group, * P<0.05, ** P < 0.01;

[0084] Compared with Example 1, # P<0.05, ## P<0.01.

[0085] Table 2 Comparison of arrhythmia duration in each group

[0086]

[0087] Note: Compared with the model control group, * P<0.05, ** P < 0.01;

[0088] Compared with Example 1, # P<0.05, ## P<0.01.

[0089] The incidence of VT and VF in Example 1 and Example 2 groups was significantly reduced. Compared with the comparative example 1-4 groups, the Example 1 group had a significant difference in reducing the incidence of VT and VF. Figure 1 、 Figure 2 .

[0090] The Chinese herbal composition of the present invention significantly delays the onset of arrhythmias, shortens their duration, and reduces the incidence of VT and VF, combating myocardial ischemia-reperfusion arrhythmias and demonstrating a promising therapeutic effect. Comparative results indicate that the addition of coptis root, mother-of-pearl, angelica root, dried tangerine peel, and salvia miltiorrhiza has a key impact on the anti-arrhythmic effect, demonstrating that the synergistic effects of the medicinal ingredients in the Chinese herbal composition achieve a therapeutic effect for arrhythmias.

[0091] The preferred embodiments of the present invention disclosed above are intended only to help illustrate the present invention. These preferred embodiments do not exhaustively describe all details, nor do they limit the present invention to the specific embodiments described. Obviously, many modifications and variations are possible based on the content of this specification. These embodiments are selected and described in detail in this specification to better explain the principles and practical applications of the present invention, thereby enabling those skilled in the art to better understand and utilize the present invention. The present invention is limited only by the claims and their full scope and equivalents.

Claims

1. A Chinese medicine composition for treating arrhythmia, characterized in that: The traditional Chinese medicine composition for treating arrhythmia is prepared from the following raw materials: 15-25 parts of coptis chinensis, 15-25 parts of mother-of-pearl, 15-25 parts of angelica sinensis, 10-20 parts of dried tangerine peel, 10-20 parts of rhodiola rosea, 10-20 parts of salvia miltiorrhiza, 10-20 parts of santalinum officinale, 5-12 parts of amomum villosum, 5-12 parts of polygala tenuifolia and 5-12 parts of forsythia suspensa.

2. The Chinese medicine composition for treating arrhythmia according to claim 1, characterized in that The traditional Chinese medicine composition for treating arrhythmia comprises the following raw materials: 20 parts of coptis root, 20 parts of pearl shell, 20 parts of angelica root, 15 parts of dried tangerine peel, 15 parts of rhodiola rosea, 15 parts of salvia miltiorrhiza, 15 parts of santalin, 9 parts of amomum villosum, 9 parts of polygala tenuifolia and 9 parts of forsythia.

3. The Chinese medicine composition for treating arrhythmia according to claim 1, characterized in that The traditional Chinese medicine composition for treating arrhythmia comprises the following raw materials: 20 parts of coptis root, 15 parts of pearl shell, 20 parts of angelica root, 10 parts of dried tangerine peel, 10 parts of rhodiola rosea, 20 parts of salvia miltiorrhiza, 20 parts of santalinum officinale, 10 parts of amomum villosum, 10 parts of polygala tenuifolia and 9 parts of forsythia suspensa.

4. The Chinese medicine composition for treating arrhythmia according to claim 1, characterized in that The traditional Chinese medicine composition for treating arrhythmia comprises the following raw materials: 25 parts of coptis root, 20 parts of pearl shell, 15 parts of angelica root, 20 parts of dried tangerine peel, 15 parts of rhodiola rosea, 10 parts of salvia miltiorrhiza, 20 parts of santalin, 12 parts of amomum villosum, 9 parts of polygala tenuifolia and 9 parts of forsythia suspensa.

5. The Chinese medicine composition for treating arrhythmia according to any one of claims 1 to 4, characterized in that: The preparation method of the traditional Chinese medicine composition for treating arrhythmia is as follows: weighing various medicinal materials, mixing, soaking in water, decocting, filtering, and combining the filtrate to obtain a decoction.

6. The Chinese medicine composition for treating arrhythmia according to claim 5, characterized in that The preparation method of the traditional Chinese medicine composition for treating arrhythmia is as follows: weigh various medicinal materials, soak them for 30-50 minutes, decoct them twice, add 10 times the amount of water each time, decoct them for 60-90 minutes each time, concentrate the filtrate, and combine the filtrates to obtain a decoction.

7. The Chinese medicine composition for treating arrhythmia according to claim 6, characterized in that: The preparation method of the traditional Chinese medicine composition for treating arrhythmia is as follows: weigh various medicinal materials, soak them for 50 minutes, decoct them twice, add 10 times the amount of water each time, decoct them for 90 minutes each time, concentrate the filtrate, and combine the filtrates to obtain a decoction.

8. The Chinese medicine composition for treating arrhythmia according to any one of claims 1 to 4, characterized in that: The preparation of the traditional Chinese medicine composition for treating arrhythmia is decoction, pill, gel, tablet, mixture, capsule, granule, powder or paste.

9. The Chinese medicine composition for treating arrhythmia according to claim 8, characterized in that The preparation of the traditional Chinese medicine composition for treating arrhythmia is a decoction.

10. Use of the traditional Chinese medicine composition for treating arrhythmia according to any one of claims 1 to 4 in the preparation of a medicament for preventing or treating arrhythmia.

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