A reaction vessel for processing pharmaceutical intermediates

Abstract

This application relates to the technical field of intermediate processing equipment, and more particularly to a reaction vessel for processing pharmaceutical intermediates. The reaction vessel includes a frame and a reaction vessel body mounted on the frame. A cleaning component is provided on the stirring assembly for cleaning residues remaining on the inner wall of the reaction vessel body. The stirring assembly includes a stirring motor fixed to the frame and a stirring shaft fixed to the stirring motor. The cleaning component includes a moving rod sleeved on the stirring shaft and a cleaning ring mounted on the moving rod. The cleaning ring has multiple cleaning holes. A liquid inlet is provided at the lower end of the stirring shaft. A one-way spring is provided at the liquid inlet at the lower end of the stirring shaft to seal the lower opening of the stirring shaft. A liquid extraction component is provided on the stirring shaft for drawing liquid from inside the reaction vessel body into the hollow stirring shaft. This application has the effect of making the liquid inside the reaction vessel body more uniformly heated.

Description

Technical Field

[0001] This application relates to the technical field of intermediate processing equipment, and in particular to a reaction vessel for processing pharmaceutical intermediates. Background Technology

[0002] Pharmaceutical intermediates are high-tech, high-value-added, and specifically targeted chemical raw materials or products used in drug synthesis processes. With the continuous improvement of people's living standards and the constant upgrading of pharmaceuticals, the demand for intermediates is increasing. Reactors are generally used in the production of pharmaceutical intermediates. A reaction vessel is a device used for chemical reactions, typically made of high-temperature, pressure-resistant, and corrosion-resistant materials such as stainless steel, fiberglass, and titanium alloys. It can hold reactants and catalysts and provide appropriate temperature, pressure, stirring, and control conditions to promote the reaction. Through structural design and parameter configuration of the reaction vessel, the required heating, evaporation, cooling, and low-to-high-speed mixing functions can be achieved.

[0003] For example, Chinese patent document CN220940606U discloses a reaction vessel for synthesizing pharmaceutical intermediates, comprising: a reaction vessel shell, several supports fixedly connected to the bottom of the reaction vessel shell, a top cover fixedly connected to the top of the supports, a fixing plate fixedly connected to the top of the top cover, and a motor mounted on the top of the fixing plate; wherein: a rotating rod is disposed inside the reaction vessel shell, the rotating rod passes through the fixing plate and is connected to the bottom of the motor; a catalyst box is fixedly connected to the side wall of the rotating rod, a spiral stirring tube is fixedly connected to one side of the catalyst box, the spiral stirring tube surrounds the side wall of the rotating rod, and several catalyst discharge ports are opened on the side wall of the spiral stirring tube; an upper circulation port is opened on the top side wall of the reaction vessel shell, a lower circulation port is opened on the bottom side wall of the reaction vessel shell, and a circulation pipe is arranged around the side wall of the reaction vessel shell, with both ends of the circulation pipe connected to the upper circulation port and the lower circulation port respectively. First, store a sufficient amount of catalyst in the catalyst tank. After the preparation is complete, place the substance to be reacted into the outer shell of the reactor through the feed inlet. Turn on the motor, and the power provided by the motor will drive the rotating rod to rotate. The catalyst in the catalyst tank will flow into the spiral stirring tube. The catalyst outlet on the spiral stirring tube will directly contact the substance in the outer shell of the reactor. The rotation of the rotating rod will drive the spiral stirring tube to rotate, and the spiral stirring tube will allow the substance and catalyst to come into full contact and mix.

[0004] In the aforementioned technologies, the rotating rod drives the spiral stirring tube to rotate, which allows the substances and catalysts to come into full contact and mix. However, when the reaction takes place in the intermediate body in a double-layer reactor, a heating medium is placed in the reactor jacket. During the heating process, a portion of viscous liquid will adhere to the inner wall of the reactor. This viscous liquid increases thermal resistance, slows down the heat from entering the reactor, and causes uneven heating of the liquid inside the reactor, thus increasing the reaction time of the liquid inside the reactor. Summary of the Invention

[0005] This application provides a reaction vessel for processing pharmaceutical intermediates, aiming to solve the problem of uneven heating of liquid inside the reaction vessel in related technologies.

[0006] The reaction vessel for processing pharmaceutical intermediates provided in this application adopts the following technical solution:

[0007] A reaction vessel for processing pharmaceutical intermediates includes a frame and a reaction vessel body mounted on the frame. The reaction vessel body is equipped with a stirring assembly for stirring the pharmaceutical intermediates. The stirring assembly also includes a cleaning assembly for cleaning residues remaining on the inner wall of the reaction vessel body. The stirring assembly includes a stirring motor fixed to the frame and a stirring shaft fixed to the stirring motor. The cleaning assembly includes a moving rod sleeved on the stirring shaft and a cleaning ring mounted on the moving rod. The cleaning ring has multiple cleaning holes. The frame is equipped with a drive assembly for moving the moving rod up and down. The stirring shaft has a hollow structure with a liquid inlet at its lower end. A one-way spring is provided at the lower opening of the stirring shaft to seal it. The stirring shaft is equipped with a pumping assembly for drawing liquid from the reaction vessel body into the hollow stirring shaft. The pumping assembly also pushes the liquid from the stirring shaft into the cleaning ring, which then sprays it onto the inner wall of the reaction vessel body through the cleaning holes on the cleaning ring.

[0008] By adopting the above technical solution, in the initial state, the lower end of the pumping rod is at the bottom of the stirring shaft. Then, the liquid inlet at the bottom of the stirring shaft is blocked by a one-way spring. When blocked, the liquid in the reactor body cannot enter the stirring shaft. When it is necessary to clean the inner wall of the reactor body, the drive assembly moves the moving rod upward. The moving rod moves the cleaning ring upward. During the upward movement, the pumping assembly draws the liquid in the reactor body into the hollow stirring shaft. The upward tilt of the one-way spring opens the liquid inlet of the stirring shaft, and the liquid in the reactor body is sucked into the bellows. When the cleaning ring moves to the top, the pumping assembly needs to move downward, and then push the liquid in the stirring shaft out through the cleaning hole. The liquid sprayed from the cleaning hole will clean the inner wall of the reactor body, thereby reducing the liquid residue on the inner wall of the reactor body and making the liquid in the reactor body heat more evenly.

[0009] Optionally, the liquid extraction assembly includes a bellows disposed inside the stirring shaft and a liquid extraction rod slidably connected inside the stirring shaft. The liquid extraction rod is provided with an installation assembly, and the liquid extraction rod is fixed to a movable rod by the installation assembly. One end of the bellows is fixed to the opening at the lower end of the stirring shaft, and the other end is fixed to the liquid extraction rod. The liquid extraction rod is fixed to the movable rod by the installation assembly.

[0010] By adopting the above technical solution, when it is necessary to clean the inner wall of the reactor body, the moving rod is moved upward. During the upward movement of the moving rod, the liquid suction rod is moved upward, which in turn stretches the bellows. Then, the liquid in the reactor body is sucked into the bellows from the liquid inlet. When it is necessary to clean the inner wall of the reactor body, the liquid suction rod is moved downward. The downward movement of the liquid suction rod causes the cleaning ring to move downward. Since the liquid inlet is blocked by the one-way spring, the liquid suction rod will squeeze the liquid in the bellows. The length of the bellows gradually decreases, and the liquid inside is squeezed into the cleaning ring. Finally, it is sprayed out from the cleaning hole on the cleaning ring, which facilitates the cleaning of the inner wall of the reactor body.

[0011] Optionally, the cleaning ring is provided with a connecting assembly for connecting the cleaning ring and the moving rod. The connecting assembly includes a connecting ring fixed on the moving rod and a connecting tube fixed on the connecting ring. The connecting ring is configured as a hollow structure. One end of the connecting tube is used to communicate with the cleaning ring, and the other end is used to connect with the cavity of the connecting ring.

[0012] By adopting the above technical solution, the cleaning ring is fixed to the moving rod by the connecting pipe, and the cleaning ring can be moved by the moving rod moving up and down, thus making it more convenient to adjust the cleaning ring.

[0013] Optionally, the connecting pipe is inclined, and the connecting ring is positioned above the cleaning ring.

[0014] By adopting the above technical solution, due to the inclined setting of the connecting pipe, after the liquid in the reactor body is discharged, the liquid in the connecting ring and the connecting pipe will enter the cleaning ring and finally be discharged through the cleaning hole on the cleaning ring, thereby reducing the liquid residue in the cleaning ring and the cleaning pipe.

[0015] Optionally, the mounting assembly includes a mounting block fixed to the suction rod and a connecting hole formed on the mounting block. The mounting block is fixedly mounted on the connecting ring, and the connecting hole is used to connect the cavity of the connecting ring and the chamber inside the bellows. During the movement of the connecting ring driven by the moving rod, the connecting ring will drive the suction rod to move and the bellows to extend and retract.

[0016] By adopting the above technical solution, the pumping rod is fixed on the connecting ring by the mounting block. Then, during the up-and-down movement of the moving rod, the moving rod drives the connecting ring and the mounting block set on the connecting ring to move, which in turn drives the pumping rod to move, thereby achieving the purpose of facilitating the movement of the pumping rod.

[0017] Optionally, the mounting block is provided with an adjustment component for adjusting the size of the connecting hole. When the opening of the connecting hole is at its maximum, the liquid pressure ejected from the cleaning hole is at its minimum. The adjustment component includes an adjustment shaft fixedly installed on the inner wall of the connecting hole and an adjustment plate rotatably connected to the adjustment shaft. The connecting ring is provided with a pushing component for pushing the adjustment plate to rotate. During the process of the pushing component pushing the adjustment plate to rotate, the opening of the connecting hole becomes smaller, the liquid pressure entering the connecting ring increases, and the liquid pressure ejected from the cleaning hole increases.

[0018] By adopting the above technical solution, the cleaning ring will move into the liquid inside the reactor body during its up-and-down movement. At this time, it is necessary to increase the pressure of the liquid sprayed from the cleaning hole so that the pressure of the sprayed liquid can overcome the resistance of the liquid inside the reactor body. By rotating the adjusting plate, the opening of the connecting hole on the mounting block is reduced, and then the pressure of the liquid entering the connecting pipe increases. The pressure of the liquid sprayed from the cleaning hole also increases. When the cleaning ring moves out of the liquid, it is necessary to reduce the pressure of the sprayed liquid, thereby reducing the impact force of the liquid on the reactor body. This can be achieved by simply rotating the adjusting plate to enlarge the opening on the connecting ring, and then reducing the pressure of the liquid entering the connecting pipe, thereby reducing the pressure of the sprayed liquid.

[0019] Optionally, a torsion spring is sleeved on the adjusting shaft, with one end of the torsion spring fixed to the adjusting shaft and the other end fixed to the adjusting plate.

[0020] By adopting the above technical solution, when the adjusting plate is pushed to rotate upward, the opening on the connecting hole becomes smaller. When the pushing block moves in the opposite direction, the torsion spring drives the adjusting plate to rotate in the opposite direction, and the opening on the connecting hole becomes larger.

[0021] Optionally, the pushing assembly includes a limiting rod slidably connected to the mounting block, a pushing block fixed to the limiting rod, a pushing shaft fixed to the pushing block, and a pushing strip fixed to the inner wall of the clearance groove. The pushing strip is provided with a pushing inclined surface. The limiting rod slides horizontally on the mounting block, and the sliding direction of the limiting rod is perpendicular to the axis of the adjusting shaft. The axis of the pushing shaft is parallel to the axis of the adjusting shaft, and the pushing shaft is perpendicular to the limiting rod. The side of the pushing shaft abuts against the pushing inclined surface. When the mounting block and the moving rod move downward, the pushing inclined surface will push the pushing shaft to move closer to the axis of the stirring shaft.

[0022] Optionally, the drive assembly includes a drive sleeve fixed on the frame and a drive rod fixed on the moving rod. The inner wall of the drive sleeve is provided with a threaded groove, and the drive rod is slidably connected in the threaded groove.

[0023] By adopting the above technical solution, during the rotation of the stirring shaft, the moving rod will be driven to rotate simultaneously. The rotation of the moving rod will drive the drive rod to rotate, and under the action of the threaded groove, the moving rod will move up and down. During the up and down movement of the moving rod, the suction rod will move, thereby facilitating the adjustment of the position of the suction rod and the cleaning ring on the moving rod.

[0024] Optionally, the lower surface of the adjusting plate is provided with an inclined surface, and the pushing block is provided with an arc-shaped surface, the arc-shaped surface being used to abut against the inclined surface.

[0025] In summary, this application includes at least one of the following beneficial technical effects:

[0026] 1. The suction rod moves downward, which in turn moves the cleaning ring downward. The suction rod will squeeze the liquid inside the bellows. As the length inside the bellows gradually decreases, the liquid inside will be squeezed into the cleaning ring and finally sprayed out from the cleaning hole on the cleaning ring, thus facilitating the cleaning of the inner wall of the reactor body.

[0027] 2. When removing liquid from the cleaning ring, it is necessary to reduce the pressure of the liquid spraying out, thereby reducing the impact force of the liquid on the reactor body. Simply rotate the adjusting plate to make the opening on the connecting ring larger, and then reduce the pressure of the liquid entering the connecting pipe, thereby reducing the pressure of the sprayed liquid. Attached Figure Description

[0028] Figure 1 This is a cross-sectional view of the reactor according to an embodiment of this application.

[0029] Figure 2 This is a cross-sectional view of the stirring shaft according to an embodiment of this application.

[0030] Figure 3 This is a schematic diagram of the drive sleeve and drive rod structure according to an embodiment of this application.

[0031] Figure 4 This is a schematic diagram of the cleaning ring structure according to an embodiment of this application.

[0032] Figure 5 yes Figure 4 Enlarged view of point A in the middle.

[0033] Figure 6 yes Figure 4 Enlarged view of point B in the middle.

[0034] Figure 7 This is a perspective view of the cleaning component according to an embodiment of this application.

[0035] Figure 8 yes Figure 7 A magnified view of point C in the middle.

[0036] Reference numerals: 01, Frame; 02, Reactor body; 03, Liquid inlet; 04, Clearance groove; 05, Mounting ring; 06, One-way spring; 1, Stirring assembly; 11, Stirring motor; 12, Stirring shaft; 2, Cleaning assembly; 21, Moving rod; 22, Cleaning ring; 23, Cleaning hole; 3, Liquid suction assembly; 31, Bellows; 32, Liquid suction rod; 4, Drive assembly; 41, Drive sleeve; 42, Drive rod; 43, Threaded groove; 5, Mounting assembly; 51, Mounting block; 52, Connecting hole; 6, Connecting assembly; 61, Connecting pipe; 62, Connecting ring; 7, Adjusting assembly; 71, Adjusting shaft; 72, Adjusting plate; 73, Torsion spring; 8, Pushing assembly; 81, Limiting rod; 82, Pushing block; 83, Pushing shaft; 84, Pushing bar; 85, Pushing inclined surface; 9, Inclined surface; 91, Arc-shaped surface. Detailed Implementation

[0037] The following combination Figures 1-8 This application will be described in further detail.

[0038] This application discloses a reaction vessel for processing pharmaceutical intermediates. (Refer to...) Figure 1 and Figure 2 A reaction vessel for processing pharmaceutical intermediates includes a frame 01 and a reaction vessel body 02 disposed on the frame 01. A stirring assembly 1 is disposed on the reaction vessel body 02 for stirring the pharmaceutical intermediates inside the reaction vessel body 02. A cleaning assembly 2 is disposed on the stirring assembly 1 for cleaning residues remaining on the inner wall of the reaction vessel body 02, thereby reducing the residues adhering to the inner wall of the reaction vessel body 02 and making the pharmaceutical intermediates inside the reaction vessel body 02 more uniformly heated.

[0039] Reference Figure 1 and Figure 2The stirring assembly 1 includes a stirring motor 11 fixed on the frame 01, a stirring shaft 12 fixed on the stirring motor 11, and stirring blades (not shown in the figure) fixed on the stirring shaft 12. The stirring blades are located at the bottom of the stirring shaft 12, and the stirring shaft 12 is rotatably connected to the reactor body 02. In this embodiment, the reactor body 02 is configured as a double-layer glass structure, and heat transfer oil can be introduced between the double-layer glass. The heat transfer oil can be used to heat or cool the drug intermediate in the reactor body 02. At the same time, an inlet pipe and an outlet pipe are provided on the reactor body 02. The inlet pipe is located above the reactor body 02, and the outlet pipe is located below the reactor body 02. The object to be reacted is put into the reactor body 02 through the inlet pipe and then heated by the heat transfer oil. The stirring motor 11 drives the stirring shaft 12 and the stirring blades fixed on the stirring shaft 12 to rotate, thereby mixing and stirring the drug intermediate in the reactor body 02.

[0040] Reference Figures 1 to 5 The cleaning component 2 includes a movable rod 21 sleeved on the stirring shaft 12 and a cleaning ring 22 fixed on the movable rod 21. The cleaning ring 22 has multiple cleaning holes 23. At the same time, a drive component 4 for driving the movable rod 21 to move up and down is provided on the frame 01.

[0041] Reference Figures 1 to 5 The stirring shaft 12 is a hollow structure with a liquid inlet 03 at its lower end. A liquid extraction assembly 3 is also installed on the stirring shaft 12. This assembly draws liquid from the reactor body 02 into the hollow stirring shaft 12, then pushes the liquid into the cleaning ring 22. Finally, the liquid is sprayed through the cleaning holes 23 on the cleaning ring 22 onto the inner wall of the reactor body 02. The liquid sprayed from the cleaning holes 23 cleans the inner wall of the reactor body 02, reducing liquid adhesion to the inner wall. As the driving assembly 4 moves the cleaning ring 22 up and down, different locations on the inner wall of the reactor body 02 can be cleaned, resulting in more uniform heating of the liquid inside the reactor body 02.

[0042] Reference Figures 1 to 5The drive assembly 4 includes a drive sleeve 41 fixed on the frame 01 and a drive rod 42 fixed on the moving rod 21. A threaded groove 43 is provided on the inner wall of the drive sleeve 41, and the drive rod 42 is slidably connected in the threaded groove 43. When the stirring motor 11 drives the stirring shaft 12 to rotate, the stirring shaft 12 will drive the moving rod 21 to rotate. During the rotation of the moving rod 21, the drive rod 42 will rotate. Then, under the action of the threaded groove 43, the moving rod 21 on the stirring shaft 12 can move up and down. During the up and down movement of the moving rod 21, the cleaning ring 22 will move up and down. Then, under the action of the liquid pumping assembly 3, the liquid can be pushed out from the cleaning hole 23. The liquid sprayed from the cleaning hole 23 can clean the inner wall of the reactor body 02.

[0043] Reference Figures 1 to 6 The liquid extraction assembly 3 includes a bellows 31 disposed inside the stirring shaft 12 and a liquid extraction rod 32 slidably connected inside the stirring shaft 12. An installation assembly 5 is provided on the liquid extraction rod 32, and the liquid extraction rod 32 is fixed to the moving rod 21 by the installation assembly 5. One end of the bellows 31 is fixed at the liquid inlet 03 at the lower end of the stirring shaft 12, and the other end is fixed to the liquid extraction rod 32. Since the liquid extraction rod 32 is fixed to the moving rod 21 by the installation assembly 5, a clearance groove 04 is provided on the stirring shaft 12 for the installation assembly 5 to slide. The clearance groove 04 is arranged along the length direction of the stirring shaft 12, and multiple clearance grooves 04 are provided. The multiple clearance grooves 04 are arranged at intervals along the circumference of the stirring shaft 12. Then, the bellows 31 inside the stirring shaft 12 can block the clearance groove 04 on the stirring shaft 12 to prevent liquid from entering the hollow stirring shaft 12.

[0044] Reference Figures 1 to 5 An installation ring 05 is fixedly installed at the liquid inlet 03 at the lower end of the stirring shaft 12. A one-way spring 06 is provided on the installation ring 05. The one-way spring 06 is used to block the liquid inlet 03 at the lower end of the stirring shaft 12. One end of the one-way spring 06 is fixed on the installation ring 05. Under the elastic force of the one-way spring 06, in the initial state, the one-way spring 06 is tightly attached to the surface of the installation ring 05. Then, the liquid in the reactor body 02 cannot enter the stirring shaft 12 through the liquid inlet 03 at the lower end of the stirring shaft 12.

[0045] When liquid needs to be drawn from the reactor body 02 into the stirring shaft 12, the drive assembly 4 moves the moving rod 21 upward. The upward-moving moving rod 21, through the mounting assembly 5, moves the suction rod 32 upward. During the upward movement of the suction rod 32, the bellows 31 expands. Simultaneously, due to the suction force, the one-way spring 06 tilts upward. During the tilting process, the one-way spring 06 no longer abuts against the surface of the mounting ring 05. Then, during the upward movement of the suction rod 32, the liquid in the reactor body 02 is drawn into the bellows 31. After the bellows 31 is fully expanded, the drive assembly 4 moves the moving rod 21 downward. The downward movement of the moving rod 21 will drive the pumping rod 32 and the cleaning ring 22 to move downward. At this time, the liquid in the bellows 31 will be squeezed. The liquid in the bellows 31 will enter the cleaning ring 22 through the mounting component 5, and finally be sprayed onto the inner wall of the reactor body 02 through the cleaning hole 23 on the cleaning ring 22. During the process of pushing the pumping rod 32 downward, the bellows 31 is compressed. At the same time, the liquid in the bellows 31 will push the one-way spring 06 to block the opening of the stirring shaft 12, so that the liquid in the bellows 31 cannot flow out from the opening of the stirring shaft 12, and can only be discharged from the cleaning hole 23 on the cleaning ring 22.

[0046] Reference Figures 2 to 7 A connecting component 6 is provided on the cleaning ring 22. The connecting component 6 is used to connect the cleaning ring 22 and the moving rod 21. In this embodiment, multiple cleaning holes 23 are provided on the cleaning ring 22. The multiple cleaning holes 23 are spaced apart along the circumference of the cleaning ring 22. The connecting component 6 includes a connecting ring 62 fixed on the moving rod 21 and a connecting tube 61 fixed on the connecting ring 62. The connecting ring 62 is set as a hollow structure. One end of the connecting tube 61 is used to communicate with the cleaning ring 22, and the other end is used to connect with the cavity of the connecting ring 62.

[0047] Reference Figures 2 to 7 The mounting assembly 5 includes a mounting block 51 fixed on the suction rod 32 and a connecting hole 52 opened on the mounting block 51. The mounting block 51 is fixedly mounted on the connecting ring 62, and the connecting hole 52 is used to connect the cavity of the connecting ring 62 and the chamber inside the bellows 31. The mounting block 51 on the suction rod 32 is slidably connected in the relief groove 04. Since the mounting block 51 is fixedly connected to the connecting ring 62, when the moving rod 21 drives the connecting ring 62 to move, the connecting ring 62 will drive the suction rod 32 to move and the bellows 31 to extend and retract. Multiple mounting blocks 51 are provided, and multiple mounting blocks 51 and multiple relief grooves 04 correspond one-to-one.

[0048] Initially, the cleaning ring 22 is at the bottom of the reactor body 02. As the drive assembly 4 moves the moving rod 21 upwards, the moving rod 21 moves the connecting ring 62 upwards. The upward-moving connecting ring 62 moves the connecting pipe 61 and the cleaning ring 22 upwards. Since the mounting block 51 is engaged with the connecting ring 62, it also moves the suction rod 32 upwards. During the upward movement of the suction rod 32, the bellows 31 extends, and the one-way spring 06 tilts upwards. The one-way spring 06 is spaced apart from the surface of the mounting ring 05. Then, the liquid inside the reactor body 02 is drawn into the bellows 31 through the opening of the stirring shaft 12. When the cleaning ring 22 moves upwards... The drive assembly 4 moves the moving rod 21 downward, which in turn moves the connecting ring 62 and the suction rod 32 mounted on the connecting ring 62 downward. The suction rod 32 pushes the liquid in the bellows 31 through the connecting hole 52 into the cavity of the connecting ring 62, and then through the cavity of the connecting ring 62 into the connecting pipe 61 and the cleaning ring 22. Finally, the liquid is ejected through the cleaning hole 23 on the cleaning ring 22. The ejected liquid cleans the side wall of the reactor body 02, thereby reducing the amount of liquid residue on the inner wall of the reactor body 02. This improves the thermal conductivity of the inner wall of the reactor body 02 and makes the liquid in the reactor body 02 heat up more evenly.

[0049] In this embodiment, the connecting pipe 61 is inclined, and the height of the connecting ring 62 is higher than the height of the cleaning ring 22. When the liquid in the reactor body 02 is completely discharged, the suction rod 32 is at its lowest point, and the bellows 31 is in a compressed state. Then, the liquid in the connecting ring 62 and the connecting pipe 61 will enter the cleaning ring 22 under the action of gravity. Then, the liquid in the cleaning ring 22 will flow out from the cleaning hole 23 under the action of gravity, thereby facilitating the cleaning of the liquid in the cleaning ring 22 and reducing the liquid residue in the connecting ring 62, the connecting pipe 61 and the cleaning ring 22.

[0050] Reference Figures 4 to 8 An adjustment component 7 is provided on the mounting block 51. The adjustment component 7 is used to adjust the size of the connecting hole 52. When the opening of the connecting hole 52 is at its maximum, the liquid pressure entering the connecting ring 62 is the minimum. Then the liquid pressure entering the connecting ring 62, the connecting pipe 61 and the cleaning ring 22 will also be the minimum. Finally, the liquid pressure sprayed from the cleaning hole 23 is the minimum. At this time, the impact on the inner wall of the reactor body 02 can be reduced, thereby protecting the inner wall of the reactor body 02.

[0051] When the cleaning ring 22 is inside the liquid in the reactor body 02, in order to facilitate the cleaning of the liquid on the inner wall of the reactor body 02 by the liquid sprayed from the cleaning hole 23, the pressure of the liquid sprayed from the cleaning hole 23 needs to be increased. After the pressure increases, it overcomes the resistance of the liquid in the reactor body 02, and then the inner wall of the reactor body 02 can be cleaned better. When the cleaning ring 22 is above the liquid in the reactor body 02, the connecting hole 52 is maximized, and the pressure of the liquid sprayed from the cleaning hole 23 is minimized, thereby reducing the damage of the liquid to the reactor body 02.

[0052] Reference Figures 4 to 8 The adjusting assembly 7 includes an adjusting shaft 71 fixedly installed on the inner wall of the connecting hole 52, an adjusting plate 72 rotatably connected to the adjusting shaft 71, and a torsion spring 73 sleeved on the adjusting shaft 71. One end of the torsion spring 73 is fixed to the adjusting shaft 71, and the other end is fixed to the adjusting plate 72. A pushing assembly 8 is provided on the connecting ring 62 for pushing the adjusting plate 72 to rotate. During the process of the pushing assembly 8 pushing the adjusting plate 72 to rotate, the opening of the connecting hole 52 becomes smaller, and then the liquid pressure entering the connecting ring 62 increases. When the cross-section of the connecting hole 52 becomes larger, the pushing assembly 8 no longer abuts against the adjusting plate 72. Under the action of the torsion spring 73, it will drive the adjusting plate 72 to rotate in the opposite direction, thereby facilitating the adjustment of the size of the connecting hole 52.

[0053] Reference Figures 4 to 8 The pushing assembly 8 includes a limiting rod 81 slidably connected to the mounting block 51, a pushing block 82 fixed to the limiting rod 81, a pushing shaft 83 fixed to the pushing block 82, and a pushing strip 84 fixed to the inner wall of the clearance groove 04. The pushing strip 84 is provided with a pushing inclined surface 85. The limiting rod 81 slides horizontally on the mounting block 51, and the sliding direction of the limiting rod 81 is perpendicular to the axis of the adjusting shaft 71. The axis of the pushing shaft 83 is parallel to the axis of the adjusting shaft 71, and the pushing shaft 83 is perpendicular to the limiting rod 81. The side of the pushing shaft 83 abuts against the pushing inclined surface 85.

[0054] During the simultaneous downward movement of mounting block 51 and moving rod 21, the pushing inclined surface 85 pushes the pushing shaft 83 towards the axis closer to the stirring shaft 12. As the pushing shaft 83 moves, it drives the pushing block 82 to move, which in turn pushes the adjusting plate 72 to rotate upwards, facilitating position adjustment. A return spring is fitted onto the limiting rod 81, with one end fixed to the limiting rod 81 and the other end fixed to the pushing block 82. When the pushing block 82 moves towards the axis closer to the stirring shaft 12, the return spring is compressed. During the upward movement of mounting block 51 driven by moving rod 21, the return spring pushes the limiting rod 81 to move in the opposite direction, simultaneously causing the pushing shaft 83 to abut against the pushing inclined surface 85. The adjusting plate 72 rotates in the opposite direction under the action of the torsion spring 73, making position adjustment of the adjusting plate 72 more convenient.

[0055] To facilitate the rotation of the adjusting plate 72, an inclined surface 9 is provided on the lower surface of the adjusting plate 72. Simultaneously, an arc-shaped surface 91 is provided on the pushing block 82, which abuts against the inclined surface 9. When the pushing block 82 slides horizontally towards the axis of the stirring shaft 12, the arc-shaped surface 91 on the pushing block 82 pushes the adjusting plate 72 to rotate upwards. During this rotation, the opening size of the connecting hole 52 is adjusted. The arc-shaped surface 91 reduces the friction between the pushing block 82 and the adjusting plate 72, making the rotation of the adjusting plate 72 more convenient.

[0056] The implementation principle of a reaction vessel for processing pharmaceutical intermediates according to an embodiment of this application is as follows: When reacting pharmaceutical intermediates, raw materials need to be added to the reaction vessel body 02 sequentially through the feed inlet. The raw materials added to the reaction vessel body 02 are rotated by the stirring blades. At the same time, the heat transfer oil between the double-layer reaction vessel body 02 heats the raw materials in the reaction vessel body 02. During the heating and stirring process, some raw materials will be agitated and will adhere to the inner wall of the reaction vessel body 02. At the same time, during the heating process, the inner wall of the reaction vessel body 02 in contact with the raw materials will also be covered with raw materials.

[0057] During the rotation of the stirring shaft 12, the moving rod 21 will rotate simultaneously. Under the action of the drive sleeve 41 and the threaded groove 43, the moving rod 21 will move upward. During the upward movement of the moving rod 21, the suction rod 32 and the cleaning ring 22 will also move upward. During the upward movement, the bellows 31, which is under compression, will be stretched, and due to the suction, the one-way spring 06 will tilt upward, forming a gap with the mounting ring 05. The liquid in the reactor body 02 will enter the bellows 31 through the gap between the mounting ring 05 and the one-way spring 06. After being fully stretched, the cleaning ring 22 moves to the top, and the bellows 31 is filled with liquid. At this time, the drive sleeve 41 drives the moving rod 21 to move down. The moving rod 21 moves the cleaning ring 22 and the liquid suction rod 32 down. The moving liquid suction rod 32 pushes the liquid in the bellows 31 through the connecting hole 52 into the cleaning ring 22, and finally sprays out from the cleaning hole 23. The sprayed liquid cleans the inner wall of the reactor body 02, thereby reducing the amount of liquid residue on the inner wall of the reactor body 02 and making the liquid in the reactor body 02 heat up more evenly.

[0058] The above are all preferred embodiments of this application, and are not intended to limit the scope of protection of this application. Therefore, all equivalent changes made in accordance with the structure, shape and principle of this application should be covered within the scope of protection of this application.

Claims

1. A reaction vessel for processing pharmaceutical intermediates, comprising a frame and a reaction vessel body mounted on the frame, wherein the reaction vessel body is provided with a stirring assembly for stirring the pharmaceutical intermediates, characterized in that: The stirring assembly is equipped with a cleaning component for cleaning residues remaining on the inner wall of the reactor body. The stirring assembly includes a stirring motor fixed on the frame and a stirring shaft fixed on the stirring motor. The cleaning component includes a moving rod sleeved on the stirring shaft and a cleaning ring set on the moving rod. The cleaning ring has multiple cleaning holes. The frame is equipped with a drive component for moving the moving rod up and down. The stirring shaft is a hollow structure with a liquid inlet at the lower end. A one-way spring is set at the lower end of the stirring shaft for sealing the liquid inlet. The stirring shaft is equipped with a liquid extraction component for drawing liquid from the reactor body into the hollow stirring shaft. The liquid extraction component also pushes the liquid in the stirring shaft into the cleaning ring and sprays it onto the inner wall of the reactor body through the cleaning holes on the cleaning ring. The liquid extraction assembly includes a bellows installed inside the stirring shaft and a liquid extraction rod slidably connected inside the stirring shaft. The liquid extraction rod is equipped with an installation assembly, and the liquid extraction rod is fixed to the moving rod by the installation assembly. One end of the bellows is fixed to the liquid inlet, and the other end is fixed to the liquid extraction rod. The cleaning ring is provided with a connecting assembly for connecting the cleaning ring and the moving rod. The connecting assembly includes a connecting ring fixed on the moving rod and a connecting tube fixed on the connecting ring. The connecting ring is a hollow structure. One end of the connecting tube is used to communicate with the cleaning ring, and the other end is used to connect with the cavity of the connecting ring. The connecting tube is inclined and the connecting ring is positioned above the cleaning ring. The mounting assembly includes a mounting block fixed to the suction rod and a connecting hole formed on the mounting block. The mounting block is fixedly mounted on the connecting ring, and the connecting hole is used to connect the cavity of the connecting ring and the chamber inside the bellows. As the moving rod drives the connecting ring to move, the connecting ring will drive the suction rod to move and the bellows to extend and retract.

2. The reaction vessel for processing pharmaceutical intermediates according to claim 1, characterized in that: The mounting block is equipped with an adjustment component for adjusting the size of the connecting hole. When the opening of the connecting hole is at its maximum, the liquid pressure ejected from the cleaning hole is at its minimum. The adjustment component includes an adjustment shaft fixedly installed on the inner wall of the connecting hole and an adjustment plate rotatably connected to the adjustment shaft. The connecting ring is equipped with a pushing component for rotating the adjustment plate. As the pushing component rotates the adjustment plate, the opening of the connecting hole becomes smaller, the liquid pressure entering the connecting ring increases, and the liquid pressure ejected from the cleaning hole increases.

3. The reaction vessel for processing pharmaceutical intermediates according to claim 2, characterized in that: A torsion spring is fitted onto the adjusting shaft, with one end of the torsion spring fixed to the adjusting shaft and the other end fixed to the adjusting plate.

4. The reaction vessel for processing pharmaceutical intermediates according to claim 2, characterized in that: The pushing assembly includes a limiting rod slidably connected to the mounting block, a pushing block fixed to the limiting rod, a pushing shaft fixed to the pushing block, and a pushing strip fixed to the inner wall of the clearance groove. The pushing strip is provided with a pushing inclined surface. The limiting rod slides horizontally on the mounting block, and the sliding direction of the limiting rod is perpendicular to the axis of the adjusting shaft. The axis of the pushing shaft is parallel to the axis of the adjusting shaft, and the pushing shaft is perpendicular to the limiting rod. The side of the pushing shaft abuts against the pushing inclined surface. When the mounting block and the moving rod move downward, the pushing inclined surface will push the pushing shaft to move closer to the axis of the stirring shaft.

5. The reaction vessel for processing pharmaceutical intermediates according to claim 1, characterized in that: The drive assembly includes a drive sleeve fixed on the frame and a drive rod fixed on the moving rod. The inner wall of the drive sleeve is provided with a threaded groove, and the drive rod is slidably connected in the threaded groove.

6. The reaction vessel for processing pharmaceutical intermediates according to claim 4, characterized in that: The lower surface of the adjustment plate is provided with an inclined surface, and the push block is provided with an arc-shaped surface, which is used to abut against the inclined surface.

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