Chinese herbal medicine composite special diet and preparation method thereof

Abstract

The invention relates to the technical field of special diets, in particular to a Chinese herbal medicine composite special diet and a preparation method of the Chinese herbal medicine composite special diet. The core blood pressure reducing component is prepared from the following raw materials in parts by weight: 10 to 20 parts of corn stigma, 15 to 25 parts of radix puerariae, 10 to 20 parts of semen cassiae, 10 to 20 parts of flos chrysanthemi and 8 to 15 parts of fructus gardeniae; and the synergistic conditioning component comprises the following components in parts by weight: 10-25 parts of Chinese dates, 10-20 parts of Chinese wolfberry fruits and 15-25 parts of white gourds. According to the traditional Chinese medicine composition, multi-mechanism synergistic blood pressure reduction can achieve the effects of diuresis, excretion, RAS system inhibition, vascular endothelium protection and nerve and endocrine regulation, meanwhile, the jujube, the Chinese yam and the rhizoma polygonati in the components for invigorating the spleen and replenishing qi can improve the phlegm-damp constitution, and the inducement of liver-yang hyperactivity is reduced from the source; ganoderma lucidum and cordyceps militaris in the immunoregulation component can enhance the tolerance of the body, reduce the uncomfortable reaction in the antihypertensive process, and form a comprehensive conditioning system of antihypertensive, foundation consolidation and rebound prevention.

Description

Technical Field

[0001] The present invention relates to the technical field of special diets, and in particular to a Chinese herbal medicine compound special diet and a preparation method thereof. Background Art

[0002] Hypertension is one of the most common chronic diseases worldwide. Existing antihypertensive dietary supplements often rely on single ingredients (such as apigenin and hawthorn extract), resulting in limited targets and inconsistent results. Traditional Chinese Medicine (TCM) theory posits that hypertension is closely related to "hyperactivity of liver yang and internal obstruction of phlegm and dampness," necessitating multi-faceted treatment aimed at clearing heat, calming the liver, and removing dampness and unblocking the meridians.

[0003] The market currently lacks a comprehensive diet based on traditional Chinese medicines that are both medicinal and edible, and that synergistically lowers blood pressure through multiple mechanisms: diuresis and natriuresis, vasodilation, endothelial protection, and neuromodulation. This invention addresses this gap by screening traditional Chinese medicines with demonstrated antihypertensive activity and optimizing their formulation and extraction process to develop a safe and effective special diet. Summary of the Invention

[0004] The purpose of the present invention is to provide a special diet of Chinese herbal medicines with natural ingredients and clear efficacy for assisting in lowering blood pressure, which regulates blood pressure through the synergistic action of multiple ingredients while also having the effects of enhancing immunity and improving metabolism, and to provide a preparation method that efficiently retains the active ingredients.

[0005] In order to achieve the above object, the present invention adopts the following technical solutions: A Chinese herbal compound special diet comprises a core blood pressure lowering component and a synergistic seasoning component. The raw material composition and weight proportions of the core blood pressure lowering component and the synergistic seasoning component are as follows: Core blood pressure-lowering ingredients: 10-20 parts of corn silk, 15-25 parts of kudzu root, 10-20 parts of cassia seed, 10-20 parts of chrysanthemum, 8-15 parts of gardenia; Synergistic conditioning ingredients: 10-25 parts of jujube, 10-20 parts of wolfberry, 15-25 parts of winter melon, 3-8 parts of ginseng, 5-12 parts of Ganoderma lucidum, 10-20 parts of yam, 5-12 parts of Cordyceps militaris, and 10-20 parts of Polygonatum.

[0006] As a further description of the above technical solution: The ginseng is selected from those that have been artificially cultivated for less than five years.

[0007] A method for preparing a Chinese herbal medicine compound special diet comprises the following steps: S100, raw material pretreatment: remove the core of the jujube, peel the winter melon, cut into sections for later use, then spray-clean all the medicinal materials, add the washed medicinal materials into a vacuum dryer for drying and dehydration, and then grind them into powder in a grinder. After passing through a 100-mesh sieve, they can proceed to the next step; S200, targeted extraction process: Targeted extraction includes three parts: flavonoid / saponin enrichment group extraction, polysaccharide / nucleoside enrichment group extraction, and triterpenoid / sterol extraction group extraction. The specific extraction process is as follows: Flavonoid / saponin enrichment group extraction: According to the dosage requirements of the formula, corn silk, kudzu root, cassia seed, chrysanthemum, and gardenia were weighed, and 8 times the amount of 70% ethanol was added. The mixture was added to an ultrasonic extractor for extraction. The extract was added to a vacuum filter for filtration. The filtered extract was added to a vacuum distillation recovery machine for decompression and ethanol recovery. Finally, the extract was added to a concentrator for concentration to enrich the antihypertensive active ingredients such as puerarin, cassia seed saponins, and chrysanthemum flavonoids. Polysaccharide / nucleoside enrichment group extraction: According to the dosage requirements of the formula, weigh jujube, wolfberry, Chinese yam, Cordyceps militaris, and Polygonatum sibiricum, add 10 times the amount of pure water, mix and add to a traditional Chinese medicine decoction machine and boil twice at 100°C for 1.5 hours each time. Then, combine the filtrate and add it to a concentrator for concentration to retain the spleen-tonifying and qi-invigorating polysaccharide components; Triterpene / sterol extraction group extraction: According to the dosage requirements of the formula, weigh ginseng, ganoderma lucidum, and wax gourd, add 6 times the amount of 95% ethanol, add the mixture into the mixed flow extraction equipment, reflux extraction twice, each time for 1 hour, and then add the mixture into the concentrator for concentration to extract ginsenosides, ganoderic acid and other immunomodulatory components; S300, composite preparation: adding the three extracts from step S200 into a mixer and mixing and stirring for 1 hour, and then adding them into a spray dryer to prepare composite powder; S400, preparation molding: the composite powder prepared in S300 is formed into granules, tablets or powders according to actual processing and consumption requirements; S500, sterilization packaging: The formed medicine is sterilized by irradiation sterilization equipment, and then quantitatively added into the packaging bag and sealed for storage.

[0008] As a further description of the above technical solution: In step S100 , the operating temperature of the vacuum desiccant is set to 55° C., and the drying process can be stopped when the moisture content of the medicinal material is ≤7%.

[0009] As a further description of the above technical solution: In step S200 , the working power of the ultrasonic extractor is set to 300 W, the working temperature is set to 60° C., and the working time is set to 40 minutes.

[0010] As a further description of the above technical solution: In the step S200 , the operating temperature of the concentrator in the flavonoid / saponin enrichment group extraction is set to 60° C., and the density of the concentrated product is 1.15.

[0011] As a further description of the above technical solution: In the polysaccharide / nucleoside enrichment group extraction in step S200, the operating temperature of the concentrator is set to 60° C., and the density of the concentrated product is 1.20.

[0012] As a further description of the above technical solution: In the step S200 , the working temperature of the concentrator in the triterpene / sterol extraction group is set to 60° C., and the density of the concentrated product is 1.10.

[0013] As a further description of the above technical solution: In step S300 , the air inlet temperature of the spray dryer is set to 190° C., and the air outlet temperature is set to 85° C.

[0014] As a further description of the above technical solution: In step S500 , the bagging amount of the granules and powder is 1.2 g / bag, and the specification of the tablets is 0.6 g / tablet.

[0015] In summary, due to the adoption of the above technical solution, the beneficial effects of the present invention are: 1. In the present invention, multiple mechanisms synergistically lower blood pressure. Corn silk flavonoids and gardenia glycosides increase glomerular filtration rate, promote sodium ion excretion, reduce blood volume, and achieve diuretic and excretion effects; puerarin and cassia saponins inhibit angiotensin-converting enzyme, reduce angiotensin II production, relax vascular smooth muscle, and achieve the effect of inhibiting the RAS system; chrysanthemum flavonoids and wolfberry polysaccharides scavenge free radicals, increase nitric oxide synthesis, and improve endothelium-dependent vasodilation function, achieving the effect of protecting the vascular endothelium; ginsenosides and polygonatum polysaccharides relieve stress, reduce norepinephrine levels, and inhibit the increase in blood pressure caused by sympathetic nerve excitation, achieving the effect of regulating nerves and endocrine system.

[0016] 2. In the present invention, the jujube, yam and polygonatum in the spleen-strengthening and qi-invigorating components can improve phlegm-damp constitution and reduce the cause of "liver yang hyperactivity" from the source; the ganoderma and cordyceps militaris in the immune-regulating ingredients can enhance the body's tolerance and reduce the discomfort reaction during the blood pressure lowering process, forming a comprehensive conditioning system of "lowering blood pressure - strengthening the foundation - preventing rebound".

[0017] 3. In the present invention, innovations have been made in the preparation process. Ultrasound-assisted ethanol extraction is used to target and enrich flavonoid / saponin antihypertensive components. Compared with the traditional water decoction method, the extraction yield is increased by more than 30%, and the puerarin extraction rate is ≥92%. In addition, step-by-step extraction avoids high-temperature destruction of heat-sensitive components, and the Cordyceps militaris nucleoside retention rate is ≥85%, ensuring maximum utilization of active ingredients. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 This is a flowchart of the workflow of the method for preparing a Chinese herbal medicine compound special diet proposed in the present invention. DETAILED DESCRIPTION

[0019] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making any creative efforts shall fall within the scope of protection of the present invention.

[0020] See also Figure 1 The present invention provides a technical solution: a Chinese herbal medicine compound special diet, comprising a core blood pressure lowering component and a synergistic seasoning component. The raw material composition and weight proportions of the core blood pressure lowering component and the synergistic seasoning component are as follows: Core blood pressure-lowering ingredients: 10-20 parts of corn silk, 15-25 parts of kudzu root, 10-20 parts of cassia seed, 10-20 parts of chrysanthemum, 8-15 parts of gardenia; Synergistic conditioning ingredients: 10-25 parts of jujube, 10-20 parts of wolfberry, 15-25 parts of winter melon, 3-8 parts of ginseng (artificially cultivated for less than five years), 5-12 parts of Ganoderma lucidum, 10-20 parts of yam, 5-12 parts of Cordyceps militaris, and 10-20 parts of Polygonatum.

[0021] Specifically, such as Figure 1 As shown, a method for preparing a Chinese herbal medicine compound special diet comprises the following steps: Step 1: Pre-treatment of raw materials: remove the core of jujube, peel and cut winter melon into sections for later use, then spray and clean all the medicinal materials. After cleaning, the medicinal materials are classified and added to the vacuum dryer for drying and dehydration. The working temperature of the vacuum desiccant is set to 55°C. When the moisture content of the medicinal materials is ≤7%, the drying process can be stopped, and then the materials are crushed by a grinder. After passing through a 100-mesh sieve, they can proceed to the next step. Step 2: Targeted extraction process: Targeted extraction includes three parts: flavonoid / saponin enrichment group extraction, polysaccharide / nucleoside enrichment group extraction, and triterpenoid / sterol extraction group extraction. The specific extraction process is as follows: Flavonoid / saponin enrichment group extraction: According to the dosage requirements of the formula, corn silk, kudzu root, cassia seed, chrysanthemum and gardenia were weighed, 8 times the amount of 70% ethanol was added, and the mixture was added to an ultrasonic extractor for extraction. The ultrasonic extractor was set to 300W working power, 60℃ working temperature, and 40 minutes working time. The extract was added to a vacuum filter for filtration. The filtered extract was added to a vacuum distillation recovery machine for decompression and ethanol recovery. Finally, the extract was added to a concentrator for concentration. The concentrator operating temperature was set to 60℃ and the concentrated density was 1.15. The antihypertensive active ingredients such as puerarin, cassia seed saponins, and chrysanthemum flavonoids were enriched. Polysaccharide / nucleoside enrichment group extraction: According to the dosage requirements of the formula, weigh jujube, wolfberry, Chinese yam, Cordyceps militaris, and Polygonatum sibiricum, add 10 times the amount of pure water, mix and add to a traditional Chinese medicine decoction machine and boil twice at 100°C for 1.5 hours each time. Then, add the combined filtrate to a concentrator for concentration at 60°C and a density of 1.20 to retain the spleen-strengthening and qi-invigorating polysaccharide components; Triterpene / sterol extraction group extraction: According to the dosage requirements of the formula, weigh ginseng, ganoderma lucidum and wax gourd, add 6 times the amount of 95% ethanol, add the mixture into the mixed flow extraction equipment and reflux extraction twice, each time for 1 hour, and then add the mixture into the concentrator for concentration. The working temperature of the concentrator is set to 60℃ and the density of the concentrate is 1.10 to extract ginsenosides, ganoderic acid and other immunomodulatory components; Step 3: Composite preparation: Add the three extracts from step 2 into a mixer and mix and stir for 1 hour, then add them into a spray dryer. The inlet air temperature of the spray dryer is set to 190°C and the outlet air temperature is set to 85°C to obtain composite powder. Step 4: Formulation: The composite powder prepared in step 3 is formed into granules, tablets or powders according to actual processing and consumption requirements; Step 5: Sterilization and packaging: The finished medicine is sterilized by irradiation sterilization equipment. The bagging amount of granules and powders is 1.2g / bag, and the specification of tablets is 0.6g / tablet. Then, it is quantitatively added into the packaging bag or bottle and sealed for storage.

[0022] Example 1 A Chinese herbal compound special diet was prepared by adding 10 parts of corn silk, 15 parts of kudzu root, 10 parts of cassia seed, 10 parts of chrysanthemum, 8 parts of gardenia, 10 parts of jujube, 10 parts of wolfberry, 15 parts of wax gourd, 3 parts of ginseng, 5 parts of ganoderma lucidum, 10 parts of yam, 5 parts of cordyceps militaris and 10 parts of polygonatum according to the above preparation method, and the mixture was made into granules with a weight of 1.2 g per bag.

[0023] Forty volunteers with elevated blood pressure were randomly divided into two groups, each consisting of 20 participants. The experimental group took one bag of the product prepared in this example twice daily, while the control group took a placebo. After three months of continuous use, the blood pressure levels of the volunteers in both groups were measured. The results showed that the blood pressure of the volunteers in the experimental group decreased significantly compared to the control group, as shown in the following table (data in the table are average values):

[0024] Example 2 A Chinese herbal compound special diet was prepared by adding 15 parts of corn silk, 20 parts of kudzu root, 15 parts of cassia seed, 15 parts of chrysanthemum, 12 parts of gardenia, 17 parts of jujube, 15 parts of wolfberry, 20 parts of wax gourd, 5 parts of ginseng, 9 parts of ganoderma lucidum, 15 parts of yam, 8 parts of cordyceps militaris and 15 parts of polygonatum according to the above preparation method, and the powder was made into 1.2 g / bag.

[0025] Forty volunteers with elevated blood pressure were randomly divided into two groups, each consisting of 20 participants. The experimental group took one bag of the product prepared in this example twice daily, while the control group took a placebo. After three months of continuous use, the blood pressure levels of the volunteers in both groups were measured. The results showed that the blood pressure of the volunteers in the experimental group decreased significantly compared to the control group, as shown in the following table (data in the table are average values):

[0026] Example 3 20 parts of corn silk, 25 parts of kudzu root, 20 parts of cassia seed, 20 parts of chrysanthemum, 15 parts of gardenia, 25 parts of jujube, 20 parts of wolfberry, 25 parts of wax gourd, 8 parts of ginseng, 12 parts of ganoderma lucidum, 20 parts of yam, 12 parts of cordyceps militaris and 10-20 parts of polygonatum were prepared as described above to prepare a Chinese herbal medicine compound special diet, and made into tablets of 0.6g / tablet. 40 volunteers with high blood pressure were selected and randomly divided into two groups, with 20 people in each group. The experimental group took the product prepared in this embodiment twice a day, 2 tablets each time; the control group took a placebo. After taking it for 3 consecutive months, the blood pressure levels of the two groups of volunteers were tested. The results showed that the blood pressure data of the volunteers in the experimental group were significantly lower than those in the control group, as shown in the following table (the data in the table are average values):

[0027] In order to further verify whether the Chinese herbal compound special diet prepared by the above preparation method meets the dietary safety standards, China Testing International Certification Group Co., Ltd. was commissioned to test the Chinese herbal compound special diet. The official website of the testing unit is https: / / mycti.cti-cert.com, and the test report number is A2240811479101001C. Among them, the Chinese herbal compound special diet did not contain 12 chemical antihypertensive drugs such as atenolol, captopril, clonidine hydrochloride, reserpine, nifedipine, hydrochlorothiazide, amlodipine, nitrendipine, nimodipine, nisoldipine, felodipine and prazosin hydrochloride. The special diet does not contain illegally added Western medicine ingredients, complies with the Food Safety Law and relevant regulations on special diets, and avoids the safety performance of side effects that may be caused by chemical drugs.

[0028] In summary, this Chinese herbal compound special diet meets the special dietary standards. The Chinese herbal compound special diet is composed of thirteen Chinese medicinal materials with medicinal and edible properties, including jujube, corn silk, wolfberry, wax gourd, ginseng (artificially cultivated for less than five years), Ganoderma lucidum, yam, cassia seed, Cordyceps militaris, Pueraria root, Gardenia jasminoides, Polygonatum sibiricum and chrysanthemum. Through ultrasound-assisted extraction and other processes, active ingredients such as flavonoids and saponins are enriched to achieve synergistic blood pressure reduction through multiple mechanisms such as diuresis and sodium excretion, vasodilation, and endothelial protection, and improve vascular endothelial function. It is suitable as a safe and natural antihypertensive auxiliary food. At the same time, the preparation process efficiently retains the active ingredients, and the preparation forms are diverse, including granules, tablets and powders, to meet the needs of different groups of people.

[0029] The above description is only a preferred specific embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any technician familiar with the technical field, within the technical scope disclosed by the present invention, who makes equivalent replacements or changes based on the technical solution and inventive concept of the present invention, should be covered by the scope of protection of the present invention.

Claims

1. A Chinese herbal medicine compound special diet, characterized in that: It includes a core blood pressure lowering component and a synergistic seasoning component. The raw material composition and weight proportions of the core blood pressure lowering component and the synergistic seasoning component are as follows: Core blood pressure lowering ingredients: 10-20 parts of corn silk, 15-25 parts of kudzu root, 10-20 parts of cassia seed, 10-20 parts of chrysanthemum, 8-15 parts of gardenia; Synergistic conditioning ingredients: 10-25 parts of jujube, 10-20 parts of wolfberry, 15-25 parts of winter melon, 3-8 parts of ginseng, 5-12 parts of Ganoderma lucidum, 10-20 parts of yam, 5-12 parts of Cordyceps militaris, and 10-20 parts of Polygonatum.

2. The Chinese herbal medicine compound special diet according to claim 1, characterized in that: The ginseng is selected from artificial cultivation for less than five years.

3. The method for preparing a Chinese herbal medicine compound special diet according to claim 1, characterized in that: The steps are as follows: S100, raw material pretreatment: remove the core of the jujube, peel the winter melon, cut into sections for later use, then spray-clean all the medicinal materials, add the washed medicinal materials into a vacuum dryer for drying and dehydration, and then grind them into powder in a grinder. After passing through a 100-mesh sieve, they can proceed to the next step; S200, targeted extraction process: Targeted extraction includes three parts: flavonoid / saponin enrichment group extraction, polysaccharide / nucleoside enrichment group extraction, and triterpenoid / sterol extraction group extraction. The specific extraction process is as follows: Flavonoid / saponin enrichment group extraction: According to the dosage requirements of the formula, corn silk, kudzu root, cassia seed, chrysanthemum, and gardenia are weighed, 8 times the amount of 70% ethanol is added, and the mixture is added to an ultrasonic extractor for extraction processing. The extract is added to a vacuum filter for filtration. The filtered extract is added to a vacuum distillation recovery machine to recover ethanol under reduced pressure. Finally, the extract is added to a concentrator for concentration to enrich antihypertensive active ingredients such as puerarin, cassia seed saponins, and chrysanthemum flavonoids; Polysaccharide / nucleoside enrichment group extraction: According to the dosage requirements of the formula, weigh jujube, wolfberry, Chinese yam, Cordyceps militaris, and Polygonatum sibiricum, add 10 times the amount of pure water, mix and add to a traditional Chinese medicine decoction machine and boil twice at 100°C for 1.5 hours each time. Then, combine the filtrate and add it to a concentrator for concentration to retain the spleen-tonifying and qi-invigorating polysaccharide components; Triterpene / sterol extraction group extraction: According to the dosage requirements of the formula, weigh ginseng, ganoderma lucidum, and wax gourd, add 6 times the amount of 95% ethanol, add the mixture into the mixed flow extraction equipment, reflux extraction twice, each time for 1 hour, and then add the mixture into the concentrator for concentration to extract ginsenosides, ganoderic acid and other immunomodulatory components; S300, composite preparation: adding the three extracts in step S200 into a mixer and mixing and stirring for 1 hour, and then adding them into a spray dryer to prepare composite powder; S400, preparation molding: the composite powder prepared in S300 is formed into granules, tablets or powders according to actual processing and consumption requirements; S500, Sterilization Packaging: The formed medicine is sterilized by irradiation sterilization equipment, and then quantitatively added into packaging bags or bottles for sealed storage.

4. The method for preparing a Chinese herbal medicine compound special diet according to claim 3, characterized in that: In step S100 , the operating temperature of the vacuum desiccant is set to 55° C., and the drying process can be stopped when the moisture content of the medicinal material is ≤7%.

5. The method for preparing a Chinese herbal medicine compound special diet according to claim 3, characterized in that: In step S200 , the working power of the ultrasonic extractor is set to 300 W, the working temperature is set to 60° C., and the working time is set to 40 minutes.

6. The method for preparing a Chinese herbal medicine compound special diet according to claim 3, characterized in that: In the step S200 , the operating temperature of the concentrator in the flavonoid / saponin enrichment group extraction is set to 60° C., and the density of the concentrated product is 1.

15.

7. The method for preparing a Chinese herbal medicine compound special diet according to claim 3, characterized in that: In the polysaccharide / nucleoside enrichment group extraction in step S200, the operating temperature of the concentrator is set to 60° C., and the density of the concentrated product is 1.

20.

8. The method for preparing a Chinese herbal medicine compound special diet according to claim 3, characterized in that: In the step S200 , the working temperature of the concentrator in the triterpene / sterol extraction group is set to 60° C., and the density of the concentrated product is 1.

10.

9. The method for preparing a Chinese herbal medicine compound special diet according to claim 3, characterized in that: In step S300 , the air inlet temperature of the spray dryer is set to 190° C., and the air outlet temperature is set to 85° C.

10. The method for preparing a Chinese herbal medicine compound special diet according to claim 3, characterized in that: In step S500 , the bagging amount of the granules and powder is 1.2 g / bag, and the specification of the tablets is 0.6 g / tablet.

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