Hot rhizoma cibotii formula granules and preparation method thereof

Abstract

The invention provides scalded rhizoma cibotii formula granules and a preparation method thereof. The preparation method sequentially comprises the steps of processing, decocting and extracting, concentrating, drying and granulating. Wherein the processing step comprises the following steps: adding river sand with a first preset weight into a container, and heating the river sand to 180-210 DEG C; putting a rhizoma cibotii piece with a second preset weight into the river sand, and scalding until the surface of the rhizoma cibotii piece bulges; when the temperature of the rhizoma cibotii slices is 180-210 DEG C, taking out the rhizoma cibotii slices from the container; and screening out the river sand, cooling to room temperature, and cutting into particles to obtain the scalded rhizoma cibotii decoction pieces. The preparation method solves the problem that the content of protocatechuic acid in the hot cibotium rhizome dry paste powder is low in the existing preparation method of the hot cibotium rhizome formula granules.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of traditional Chinese medicine formula granules, in particular to a preparation method of formula granules of Sinocrassula indica and formula granules of Sinocrassula indica. BACKGROUND

[0002] In the related art, formula granules of Sinocrassula indica are prepared from Sinocrassula indica raw medicinal materials through processing, decoction extraction, concentration, drying, and granulation. The processing method of Sinocrassula indica is as follows: river sand is heated to 140℃, and Sinocrassula indica tablets are put into the river sand, and the Sinocrassula indica tablets are cooked until the surface of the Sinocrassula indica tablets is swollen, and the material is taken out when the temperature of the Sinocrassula indica tablets is 150℃, and the river sand is sieved out, and the Sinocrassula indica tablets are cooled to room temperature and cut into granules to obtain Sinocrassula indica decoction pieces; wherein the weight ratio of the Sinocrassula indica tablets to the river sand is 5:1. However, the content of protocatechuic acid in the Sinocrassula indica decoction pieces obtained by using the above processing method is low, only 0.05 mg / g; which leads to a low content of protocatechuic acid in the subsequent dry extract powder. SUMMARY

[0003] In view of the above problems, the present application is proposed in order to provide a preparation method of formula granules of Sinocrassula indica and formula granules of Sinocrassula indica which can overcome the above problems or at least partially solve the above problems, can solve the technical problem of low content of protocatechuic acid in the dry extract powder of the existing formula granules of Sinocrassula indica, and can improve the quality of the formula granules of Sinocrassula indica.

[0004] Specifically, the present application provides a preparation method of formula granules of Sinocrassula indica, which comprises the steps of processing, decoction extraction, concentration, drying, and granulation in sequence to obtain the formula granules of Sinocrassula indica.

[0005] The processing step comprises:

[0006] A first preset weight of river sand is added to a container, and the river sand is heated to 180-210℃;

[0007] A second preset weight of Sinocrassula indica tablets is put into the river sand, and the Sinocrassula indica tablets are cooked until the surface of the Sinocrassula indica tablets is swollen;

[0008] The Sinocrassula indica tablets are taken out from the container when the temperature of the Sinocrassula indica tablets is 180-210℃;

[0009] The river sand is sieved out, and the Sinocrassula indica tablets are cooled to room temperature and cut into granules to obtain Sinocrassula indica decoction pieces.

[0010] Optionally, the ratio of the first preset weight to the second preset weight is greater than 1:5.

[0011] Optionally, the ratio of the first preset weight to the second preset weight is 3:5.

[0012] Optionally, the decoction extraction step comprises:

[0013] The hot dog spine decoction pieces are put into an extraction tank and soaked at room temperature for 0.5 to 1.5 hours, and then heated to 100℃;

[0014] The extraction is sequentially performed for three times, and the extraction liquid obtained in each extraction is combined and filtered to obtain hot dog spine filtrate;

[0015] In each extraction, the amount of water added in the extraction tank is 10 to 12 times the weight of the hot dog spine decoction pieces, and the extraction time is 0.5 to 1 hour.

[0016] Optionally, in the decoction extraction step:

[0017] In the first extraction, the extraction time is 1 hour, and the amount of water added in the extraction tank is 12 times the weight of the hot dog spine decoction pieces;

[0018] In the second extraction, the extraction time is 0.5 hour, and the amount of water added in the extraction tank is 10 times the weight of the hot dog spine decoction pieces;

[0019] In the third extraction, the extraction time is 0.5 hour, and the amount of water added in the extraction tank is 10 times the weight of the hot dog spine decoction pieces.

[0020] Optionally, the concentration step comprises: concentrating the hot dog spine filtrate to obtain concentrated medicinal paste;

[0021] The drying step comprises: spray drying the concentrated medicinal paste to obtain dry paste powder;

[0022] The granulation step comprises: dry compression granulation of the dry paste powder to obtain hot dog spine formula granules.

[0023] Optionally, in the concentration step: the steam pressure is not more than 0.12 MPa, the vacuum degree is -0.03 to -0.09 MPa, the concentration temperature is 50 to 85℃, and the relative density of the concentrated medicinal paste is 1.01 to 1.10;

[0024] In the drying step: the inlet air temperature is 120 to 180℃, the outlet air temperature is 80 to 110℃, and the liquid inlet frequency is 5.0 to 30.0 Hz;

[0025] In the granulation step: dry compression granulation is used for granulation, the screen mesh number of the granulator is 12 meshes, the screen mesh number for sizing is 10 meshes and 40 meshes, the material conveying speed is 20 to 230 r / min, the speed of the pressure roller is 3 to 40 r / min, and the sizing speed is 20 to 230 r / min; the weight ratio of dry paste powder to lactose during granulation is 1:0 to 1:0.5;

[0026] The total amount of auxiliary materials used in the drying step and the granulation step is ≤5% of the amount of hot dog spine decoction pieces.

[0027] In another aspect, the present application also provides a prepared granule of Radix Sinocrassulae, which is prepared by the preparation method of any one of the above-mentioned preparation methods.

[0028] Advantages of the present application:

[0029] In the preparation method of the prepared granule of Radix Sinocrassulae, in the processing step, by increasing the heating temperature of the river sand and the taking-out temperature (out-of-pan temperature) of the Radix Sinocrassulae tablets, the processing temperature is limited to 180-210℃, which can significantly increase the content of protocatechuic acid in the processed Radix Sinocrassulae decoction pieces, to 0.24-0.38mg / g, which is 4.8-7.6 times higher than 0.05mg / g in the related art; thereby the subsequent extraction yield and the content of protocatechuic acid in the dry extract powder can be increased, and the quality of the prepared granule of Radix Sinocrassulae can be improved.

[0030] Further, by increasing the ratio of the amount of river sand to the amount of Radix Sinocrassulae tablets, on the one hand, it is beneficial to uniformly heat the Radix Sinocrassulae tablets, thereby improving the content of protocatechuic acid in the Radix Sinocrassulae decoction pieces; on the other hand, it can improve the heating efficiency of the Radix Sinocrassulae tablets, thereby improving the processing efficiency.

[0031] Further, by setting reasonable process parameters (decoction, concentration, drying, granulation), the stable transfer of high content protocatechuic acid in the final granule and the granule formability can be ensured.

[0032] The above and other objects, advantages and features of the present application will become more apparent from the following detailed description of some embodiments thereof, when taken in conjunction with the accompanying drawings. BRIEF DESCRIPTION OF DRAWINGS

[0033] Some specific embodiments of the present application will be described in detail below with reference to the accompanying drawings, in an exemplary and non-limiting manner. The same reference numerals in the drawings denote the same or similar components or parts. Those skilled in the art should understand that these drawings are not necessarily drawn to scale. In the drawings:

[0034] Figure 1 is a schematic structural diagram of the preparation method of the prepared granule of Radix Sinocrassulae according to an embodiment of the present application. DETAILED DESCRIPTION

[0035] The following will be described with reference to Figure 1The dog spine scalding formula granules and the preparation method thereof are described in the embodiments of the present application. In the description of the embodiments, it should be understood that the terms "first", "second" are used only for the purpose of description and should not be understood as indicating or implying relative importance or implying the number of the indicated technical features. Therefore, the features defined as "first", "second" can explicitly or implicitly include at least one of the features, that is, one or more of the features. In the description of the present application, the meaning of "a plurality of" is at least two, for example, two, three, etc., unless otherwise specifically limited. When a certain feature "includes or contains" a certain or certain features, unless otherwise specifically described, it indicates that other features are not excluded and can further include other features.

[0036] In the description of the embodiments, the description with reference to the terms "one embodiment", "some embodiments", "illustrative embodiment", "example", "specific example", or "some examples" means that the specific features, structures, materials or characteristics described in connection with the embodiment or example are included in at least one embodiment or example of the present application. In the present specification, the illustrative description of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner.

[0037] As shown in Figure 1 The present embodiment provides a preparation method of dog spine scalding formula granules, which comprises the steps of processing, decocting and extracting, concentrating, drying and granulating in sequence, and finally obtaining the dog spine scalding formula granules.

[0038] The processing step specifically comprises: adding a first preset weight of river sand into a container, heating the river sand to 180-210℃; adding a second preset weight of dog spine slices into the river sand, and scalding until the surface of the dog spine slices is swollen; taking out the dog spine slices from the container when the temperature of the dog spine slices is 180-210℃; sieving out the river sand, cooling to room temperature, and cutting into granules to obtain the dog spine decoction pieces.

[0039] In the present embodiment, the ratio of the first preset weight to the second preset weight is greater than or equal to 1:5.

[0040] In the processing step, by increasing the heating temperature of the river sand and the taking-out temperature (out-of-pan temperature) of the dog spine slices, the processing temperature is limited to 180-210℃, which can significantly increase the content of protocatechuic acid in the processed dog spine decoction pieces, thereby improving the subsequent extract yield and the content of protocatechuic acid in the dry extract powder.

[0041] In some optional embodiments of the present application, in the processing step, the river sand is heated to 180-200℃; and the dog spine slices are taken out from the container when the temperature of the dog spine slices is 180-200℃. That is, the processing temperature is 180-200℃.

[0042] In some optional embodiments of the present application, the ratio of the first preset weight to the second preset weight is greater than 1:5.

[0043] In the present embodiment, by increasing the ratio of the amount of river sand used to the amount of Goujizi pieces, on the one hand, it is beneficial to uniformly heat the Goujizi pieces, thereby facilitating the increase of the content of protocatechuic acid in the Goujizi decoction pieces; on the other hand, it can improve the heating efficiency of the Goujizi pieces, thereby facilitating the improvement of the processing efficiency.

[0044] In some optional embodiments of the present application, the ratio of the first preset weight to the second preset weight is greater than 3:5.

[0045] The present embodiment optimizes the ratio of the amount of river sand used to the amount of Goujizi pieces, better balances the heating uniformity, heating efficiency and the use cost of river sand.

[0046] In some optional embodiments of the present application, the decoction and extraction step comprises the following steps: after the Goujizi decoction pieces are put into the extraction tank for 0.5 to 1.5 hours of normal temperature soaking, the temperature is raised to 100℃; three extractions are carried out in turn, the extraction liquid obtained in each extraction is combined, and after filtration, the Goujizi filtrate is obtained; wherein, during each extraction, the amount of water added in the extraction tank is 10 to 12 times the weight of the Goujizi decoction pieces, and the extraction time of each extraction is 0.5 to 1 hour.

[0047] In the present embodiment, by setting appropriate decoction and extraction process steps and parameters, it is beneficial to further improve the extraction rate of protocatechuic acid, thereby further improving the extraction rate and the content of protocatechuic acid in the dry extract powder.

[0048] In some optional embodiments of the present application, in the decoction and extraction step: during the first extraction, the extraction time is 1 hour, the amount of water added in the extraction tank is 12 times the weight of the Goujizi decoction pieces, and it is sieved through a 60-mesh sieve; during the second extraction, the extraction time is 0.5 hour, the amount of water added in the extraction tank is 10 times the weight of the Goujizi decoction pieces, and it is sieved through a 60-mesh sieve; during the third extraction, the extraction time is 0.5 hour, the amount of water added in the extraction tank is 10 times the weight of the Goujizi decoction pieces, and it is sieved through a 60-mesh sieve.

[0049] In the present embodiment, by limiting the specific time and water amount of each extraction, the process operation can be standardized and highly repeatable, ensuring production stability and batch consistency. Further, the gradient water amount design is more scientific and economical, which not only ensures sufficient extraction of the first decoction, but also reduces the water amount of the last two decoctions, significantly reduces the subsequent concentration energy consumption, and improves the overall production efficiency. Furthermore, precise control of the extraction time helps to balance the thermal stability and impurity control while fully extracting protocatechuic acid, thereby more stably and reliably achieving high extraction rate, high transfer rate and high extraction rate.

[0050] In some optional embodiments of the present application, the concentrating step comprises concentrating the hot dog spine filtrate to obtain concentrated ointment.

[0051] The drying step comprises spray drying the concentrated ointment to obtain dry ointment powder.

[0052] The granulating step comprises dry pressing the dry ointment powder to obtain hot dog spine formula granules.

[0053] In some optional embodiments of the present application, in the concentrating step: the steam pressure is not more than 0.12 MPa, the vacuum degree is -0.03 to -0.09 MPa, the concentration temperature is 50 to 85℃, and the relative density of the concentrated ointment is 1.01 to 1.10.

[0054] In this embodiment, the concentrated ointment can also be called extract. In the process of preparing the extract, steam pressure, concentration temperature and relative density (specific gravity) are three core parameters, which have important influence on the quality and production efficiency of the extract.

[0055] Steam pressure refers to the pressure of the steam generated by the steam generator or steam boiler during the concentration process. The steam pressure directly affects the temperature of the steam and the heat transfer efficiency. Generally speaking, the higher the steam pressure, the higher the steam temperature and the higher the heat transfer efficiency, thereby accelerating the concentration speed of the extract. However, too high steam pressure may cause some components in the extract to be destroyed or volatilized. In this embodiment, the appropriate steam pressure is selected according to the components, properties and concentration requirements of the extract, so as to ensure the safe operation of the steam generator and steam pipeline and avoid safety accidents such as overpressure.

[0056] Concentration temperature refers to the temperature environment of the extract during the concentration process. The concentration temperature directly affects the evaporation rate of water in the extract and the viscosity of the extract. Generally speaking, the higher the concentration temperature, the faster the evaporation rate of water and the higher the viscosity of the extract. However, too high concentration temperature may cause some components in the extract to be destroyed or have adverse reactions. In this embodiment, the appropriate concentration temperature is set according to the components, properties and concentration requirements of the extract, so as to ensure the accuracy and stability of the heating equipment and temperature control system and avoid the influence of temperature fluctuation on the quality of the ointment.

[0057] Relative density refers to the ratio of the density of the extract to the density of water, which is usually used to measure the viscosity and concentration of the extract. Generally speaking, the higher the relative density, the higher the viscosity and stability of the extract. However, too high relative density will affect the spray drying effect. In this embodiment, by setting a reasonable relative density, the texture, stability and use effect of the extract can be guaranteed.

[0058] Therefore, the embodiment can obtain high-quality extract and has high production efficiency by setting reasonable concentration process parameters, and can ensure the accuracy, stability and safety of the production equipment.

[0059] In some optional embodiments of the present application, in the drying step: the inlet air temperature is 120-180°C, the outlet air temperature is 80-110°C, and the liquid inlet frequency is 5.0-30.0 Hz.

[0060] In the embodiment, the inlet air temperature refers to the temperature of the hot gas entering the drying tower, which directly affects the heat obtained by the mist droplets and the evaporation rate of the moisture. By setting the inlet air temperature to 120-180°C, a higher moisture evaporation rate can be achieved, and the effective ingredients in the product will not be damaged. The outlet air temperature determines the final state of the dried extract powder. If the outlet air temperature is too high, the product may be charred, melted or decomposed. If the outlet air temperature is too low, the product may be in a semi-dry state, causing adhesion or aggregation to adhere to the bottom of the drying chamber. In order to avoid the influence of the outlet air temperature on the dried extract powder, the outlet air temperature is set to 80-110°C in the embodiment, so that a dried extract powder with high quality can be obtained. The liquid inlet frequency refers to the rate of feeding the liquid into the spray drying tower, which determines the number and size of the mist droplets. If the liquid inlet speed is too fast, the mist droplets may be too large and not completely dried. If the liquid inlet speed is too slow, the production efficiency may be reduced. In the embodiment, the liquid inlet frequency is set to 5.0-30.0 Hz, so that the mist droplet size is uniform and the drying effect is good.

[0061] Therefore, the embodiment is beneficial to controlling the preparation efficiency and quality of the dried extract powder by setting reasonable drying process parameters.

[0062] In some optional embodiments of the present application, in the granulation step: dry compression granulation is used, the screen mesh number of the granulator is 12 meshes, the screen mesh number for sizing is 10 meshes and 40 meshes, the material conveying speed is 20-230 r / min (for example: 20 r / min, 50 r / min, 80 r / min, 100 r / min, 150 r / min, 200 r / min, or 230 r / min), the speed of the pressure roller is 3-40 r / min (for example: 3 r / min, 10 r / min, 20 r / min, 30 r / min, or 40 r / min), and the sizing speed is 20-230 r / min (20 r / min, 50 r / min, 80 r / min, 100 r / min, 150 r / min, 200 r / min, or 230 r / min); the weight ratio of the dried extract powder to lactose during the granulation process is 1:0-1:0.5.

[0063] The total amount of the auxiliary materials in the drying step and the granulation step is ≤5% of the amount of the Cibotii Rhizoma decoction.

[0064] In the present embodiment, the granulation step specifically comprises: uniformly mixing the dry paste powder and lactose in a certain proportion, adding the mixed material into a dry compression granulator; adjusting parameters such as the rotation speed of the compression wheel and the compression wheel pressure to compress the material into a sheet; cutting the sheet into granules through a crushing chamber; and performing granule sizing treatment on the granules through different size screens to obtain granules of the required formula. The screen mesh count directly affects the size of the granules; a low mesh count results in large granules; a high mesh count results in fine granules; and the present embodiment can obtain granules of a reasonable size by setting a reasonable screen mesh count. The material conveying speed affects the rate at which the material enters the dry compression granulator; the rotation speed of the compression wheel affects the compression time and pressure distribution of the material in the nip area of the roller; and the present embodiment can ensure that the material can enter the compression wheel area for compression uniformly and stably by setting a reasonable material conveying speed and compression wheel rotation speed. The proportion of the dry paste powder and lactose affects the formability, stability and solubility of the granules; and the present embodiment can ensure that the granules have good flowability and disintegrability by setting an appropriate proportion.

[0065] Therefore, the present embodiment is conducive to controlling the quality and yield of the dog spine formula granules by setting reasonable granulation process parameters.

[0066] Another aspect of the present embodiment also provides a dog spine formula granule prepared by the preparation method of any one of the above embodiments.

[0067] The preparation method of the present application will be described in detail below in conjunction with specific embodiments.

[0068] Embodiment 1

[0069] A preparation method of a dog spine formula granule comprises the following steps:

[0070] Processing: 30 kg of river sand is added to a container, and the river sand is heated to 180℃; 50 kg of dog spine slices are put into the river sand, and the dog spine slices are heated until the surface of the dog spine slices is swollen; the dog spine slices are taken out of the container when the temperature of the dog spine slices is 180℃; the river sand is sieved out, and the dog spine slices are cooled to room temperature and cut into coarse granules to obtain dog spine slices.

[0071] Decoction extraction: the dog spine slices are put into an extraction tank, and water is added, with the amount of water being 12 times the weight of the dog spine slices; after soaking at room temperature for 1.5 h, the temperature is increased to 100℃, and then the first extraction (micro-boiling) is performed for 1 h; then the second extraction (micro-boiling) and the third extraction (micro-boiling) are performed, wherein the extraction time of the second extraction and the third extraction is 0.5 h, and the amount of water added is 10 times the weight of the dog spine slices; finally, the extraction liquids obtained in each extraction are combined, filtered, and a dog spine filtrate is obtained.

[0072] Concentrating: concentrating the hot dog spine filtrate to obtain concentrated ointment; wherein the steam pressure is not more than 0.12 MPa, the vacuum degree is-0.03 to-0.09 MPa, the concentration temperature is 50 to 85℃, and the relative density of the concentrated ointment is 1.01 to 1.10;

[0073] Drying: taking the concentrated ointment to spray drying to obtain dry ointment powder; wherein the inlet air temperature is 120 to 180℃, the outlet air temperature is 80 to 110℃, and the liquid inlet frequency is 5.0 to 30.0 Hz;

[0074] Granulating: taking the dry ointment powder to dry compression granulation to obtain hot dog spine formula granules; wherein the granulation adopts dry compression granulation method, the screen mesh number of the granulator is 12 meshes, the screen mesh number for sizing is 10 meshes and 40 meshes, the material conveying speed is 20 to 230 r / min, the speed of the compression wheel is 3 to 40 r / min, and the sizing speed is 20 to 230 r / min; the weight ratio of the dry ointment powder to lactose in the granulation process is 1:0 to 1:0.5; the total amount of auxiliary materials in the drying step and the granulation step is ≤5% of the feeding amount of the hot dog spine decoction pieces.

[0075] Example 2

[0076] A preparation method of hot dog spine formula granules comprises the steps of processing, decocting and extracting, concentrating, drying, and granulating in sequence. Compared with Example 1, Example 2 is only different in the processing step, and the other steps and parameters are the same.

[0077] In this example, the processing step comprises: adding 30 kg of river sand into a container, heating the river sand to 190℃, putting 50 kg of dog spine pieces into the river sand, and frying until the surface of the dog spine pieces is puffed; taking out the dog spine pieces when the temperature of the dog spine pieces is 190℃; sieving out the river sand, cooling to room temperature, cutting the dog spine pieces into coarse particles, and obtaining hot dog spine decoction pieces.

[0078] Example 3

[0079] A preparation method of hot dog spine formula granules comprises the steps of processing, decocting and extracting, concentrating, drying, and granulating in sequence. Compared with Example 1, Example 3 is only different in the processing step, and the other steps and parameters are the same.

[0080] In this example, the processing step comprises: adding 30 kg of river sand into a container, heating the river sand to 200℃, putting 50 kg of dog spine pieces into the river sand, and frying until the surface of the dog spine pieces is puffed; taking out the dog spine pieces when the temperature of the dog spine pieces is 200℃; sieving out the river sand, cooling to room temperature, cutting the dog spine pieces into coarse particles, and obtaining hot dog spine decoction pieces.

[0081] Example 4

[0082] A preparation method of a parched dog spine formula granule comprises the steps of processing, decocting and extracting, concentrating, drying, and granulating in sequence. In Example 4, the heating temperature of the river sand in the processing step and the temperature at which the dog spine pieces are taken out of the container are different from those in Example 1, and the other steps and parameters are the same as those in Example 1.

[0083] In this example, the processing step comprises: adding 30 kg of river sand into a container, heating the river sand to 210°C; putting 50 kg of dog spine pieces into the river sand, and parching until the surface of the dog spine pieces is swollen; taking out the dog spine pieces from the container when the temperature of the dog spine pieces is 210°C; sieving out the river sand, cooling to room temperature, cutting the dog spine pieces into coarse granules, and obtaining parched dog spine decoction pieces.

[0084] Example 5

[0085] A preparation method of a parched dog spine formula granule comprises the steps of processing, decocting and extracting, concentrating, drying, and granulating in sequence. In Example 5, only the decocting and extracting step is different from that in Example 2, and the other steps and parameters are the same as those in Example 2.

[0086] In this example, the decocting and extracting step comprises: first extraction, boiling water feeding, extraction time of 0.5 h (micro-boiling), and water amount of 12 times the weight of the parched dog spine decoction pieces; second extraction, extraction time of 0.5 h (micro-boiling), and water amount of 10 times the weight of the parched dog spine decoction pieces; and third extraction, extraction time of 0.5 h (micro-boiling), and water amount of 10 times the weight of the parched dog spine decoction pieces. That is, compared with Example 2, the soaking step is omitted, and boiling water feeding is adopted.

[0087] Example 6

[0088] A preparation method of a parched dog spine formula granule comprises the steps of processing, decocting and extracting, concentrating, drying, and granulating in sequence. In Example 6, only the decocting and extracting step is different from that in Example 2, and the other steps and parameters are the same as those in Example 2.

[0089] In this example, the decocting and extracting step comprises:

[0090] First extraction: after water feeding is completed, the parched dog spine decoction pieces are soaked for 1.0 h, and then the first extraction is started. Among them, the water amount is 12 times the weight of the parched dog spine decoction pieces, the extraction time is 1 h, and the extraction temperature is 80°C.

[0091] Second extraction: extraction time of 0.5 h (micro-boiling), and water amount of 10 times the weight of the parched dog spine decoction pieces.

[0092] Third extraction: extraction time of 0.5 h (micro-boiling), and water amount of 10 times the weight of the parched dog spine decoction pieces.

[0093] Comparative Example 1

[0094] A preparation method of a scalded dog spine dispensing granule sequentially comprises processing, decocting and extracting, concentrating, drying and granulating steps. The processing step of Comparative Example 1 is different from that of Example 1, and the other steps and parameters are the same.

[0095] In this example, the processing step comprises: adding 10 kg of river sand into a container, heating the river sand to 140℃; putting 50 kg of dog spine slices into the river sand, and scalding until the surface of the dog spine slices is swollen; taking out the dog spine slices when the temperature of the dog spine slices is 150℃; sieving out the river sand, cooling to room temperature, and cutting the dog spine slices into coarse granules to obtain scalded dog spine slices.

[0096] Comparative Example 2

[0097] A preparation method of a scalded dog spine dispensing granule sequentially comprises processing, decocting and extracting, concentrating, drying and granulating steps. The processing step of Comparative Example 1 is different from that of Example 1, and the other steps and parameters are the same.

[0098] In this example, the processing step comprises: adding 10 kg of river sand into a container, heating the river sand to 160℃; putting 50 kg of dog spine slices into the river sand, and scalding until the surface of the dog spine slices is swollen; taking out the dog spine slices when the temperature of the dog spine slices is 160℃; sieving out the river sand, cooling to room temperature, and cutting the dog spine slices into coarse granules to obtain scalded dog spine slices.

[0099] The dry extract powder of the scalded dog spine dispensing granule prepared in the above Examples 1-6 and Comparative Examples 1-2 is detected, and the results are shown in Table 1.

[0100] Table 1 Comparison of Examples 1-6 and Comparative Examples

[0101]

[0102]

[0103] From Comparative Examples 1-4 and 2, it can be seen that under the same decocting and extracting, concentrating, drying and granulating processes, changing the processing step has a greater impact on the content of protocatechuic acid in the scalded dog spine slices and the dry extract powder. The content of protocatechuic acid in the scalded dog spine slices obtained in Example 2 is the highest. When the processing temperature is greater than 200℃, protocatechuic acid may be decomposed.

[0104] From Comparative Examples 2, 5 and 6, it can be seen that under the same processing process, changing the soaking time and decocting time and temperature in the decocting and extracting step has little effect on the content of protocatechuic acid, but the extract yield of the dry extract is slightly reduced.

[0105] Therefore, considering the production factors and saving energy, Example 2 (processing at 190℃) is finally selected as the best example.

[0106] Further, 3 batches of Cibotium regale formula granules were produced according to the process of Example 2, and the feeding amount of the process test was 10 kg, and 3 batches of Cibotium regale formula granules dry extract powder were obtained. The test results of the 3 batches of test samples are shown in Table 2.

[0107] Table 2 Quality test results of 3 batches of test products

[0108]

[0109] As can be seen from Table 2, stable products can be produced according to the above process, which is suitable for large-scale production.

[0110] At this point, those skilled in the art should recognize that although the present application has been fully shown and described with reference to a number of exemplary embodiments, many other variations or modifications can be directly determined or deduced from the disclosure of the present application in accordance with the principles of the present application without departing from the spirit and scope of the present application. Therefore, the scope of the present application should be understood and recognized as covering all these other variations or modifications.

Claims

1. A method for preparing scalded dog spine formula granules, characterized in that: The method comprises the steps of processing, decoction extraction, concentration, drying and granulation in sequence; The preparation steps include: Adding a first predetermined weight of river sand into the container, and heating the river sand to 180 to 210° C.; Adding a second preset weight of spinach slices into the river sand and scalding until the surface of the spinach slices bulges; When the temperature of the dog spine slices reaches 180 to 210°C, take them out of the container; The river sand was sieved out, the mixture was cooled to room temperature, and cut into granules to obtain the hot dog spine slices.

2. The method for preparing the Tanggouji formula granules according to claim 1, characterized in that: The ratio of the first preset weight to the second preset weight is greater than 1:

5.

3. The method for preparing the Tanggouji formula granules according to claim 2, characterized in that: The ratio of the first preset weight to the second preset weight is 3:

5.

4. The method for preparing the Tanggouji formula granules according to claim 1, characterized in that: The decoction and extraction step comprises: Put the hot dog spine slices into an extraction tank and soak them at room temperature for 0.5 to 1.5 hours, then heat them to 100° C. The extraction is performed three times in sequence, and the extracts obtained from each extraction are combined and filtered to obtain a filtrate of the scalded dog spine; During each extraction, the amount of water added to the extraction tank is 10 to 12 times the weight of the scalded dog spine slices, and the time for each extraction is 0.5 to 1 hour.

5. The method for preparing the Tanggouji formula granules according to claim 4, characterized in that: In the decoction extraction step: During the first extraction, the extraction time is 1 hour, and the amount of water added is 12 times the weight of the Tanggouji slices; During the second extraction, the extraction time was 0.5 h, and the amount of water added was 10 times the weight of the Tanggouji slices; During the third extraction, the extraction time was 0.5 h, and the amount of water added was 10 times the weight of the Tanggouji slices.

6. The method for preparing the Tanggouji formula granules according to claim 1, characterized in that: The concentration step comprises: concentrating the filtrate of Tanggouji to prepare a concentrated ointment; The drying step comprises: taking the concentrated ointment and spray drying it to obtain dry ointment powder; The granulation step comprises: taking the dry paste powder and dry-pressing granules to prepare the shanggouji formula granules.

7. The method for preparing the Tanggouji formula granules according to claim 6, characterized in that: In the concentration step: the steam pressure does not exceed 0.12 MPa, the vacuum degree is -0.03 to -0.09 MPa, the concentration temperature is 50 to 85° C., and the relative density of the concentrated ointment is 1.01 to 1.10; In the drying step: the air inlet temperature is 120 to 180°C, the air outlet temperature is 80 to 110°C, and the liquid inlet frequency is 5.0 to 30.0 Hz; In the granulation step, the granulation is carried out by dry pressing granulation, the mesh size of the granulator screen is 12 mesh, the mesh size of the granulation screen is 10 mesh and 40 mesh, the feeding speed is 20 to 230 r / min, the pressing wheel speed is 3 to 40 r / min, and the granulation speed is 20 to 230 r / min; the weight ratio of the dry paste powder to lactose during the granulation process is 1:0 to 1:0.5; The sum of the amounts of the auxiliary materials used in the drying step and the granulation step is ≤5% of the amount of the Tanggouji decoction pieces fed.

8. A granule for hot dog spine, characterized in that: The scalded dog spine formula granules are prepared by the preparation method according to any one of claims 1 to 7.

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