Continuous micro-dosing device

Abstract

The invention provides a continuous micro-dosing device and an injection method. The continuous micro-dosing device comprises a needle head device, a medicine storage device, a piston push rod device, a force storage device, a stored force release device and a control device, under the action of the control device, the stored force releasing device releases the specified piston stroke, the stored force device pushes the piston push rod device to move into the medicine storage device by the specified piston stroke, and medicine liquid in the medicine storage device is discharged through the needle head device. The force storage device serves as a power source, the piston is pushed in a rotating or direct pushing mode, the number of needed pulses is calculated according to the dosage needing to be infused or the movement distance of the piston, then the control device accurately controls the force storage releasing device to release the specified piston stroke, and the accuracy of the administration dosage can be improved. A coupling assembly composed of a gear set composed of a plurality of gears is connected with the rotary magnetic brake assembly and the piston push rod device, and large force of the force storage device is controlled through small force of the rotary magnetic brake assembly.

Description

[0001] This application is a divisional application of the following original application:

[0002] Original application filing date: December 8, 2023

[0003] Original application application number: 202311685633.6

[0004] Original application invention creation name: A continuous micro-dosing device and injection method TECHNICAL FIELD

[0005] The present application relates to the technical field of medical devices, in particular to a continuous micro-dosing device and an injection method. BACKGROUND

[0006] Continuous dosing refers to continuous dosing every day to maintain the effective blood concentration of the drug. In the current clinical medical system, continuous dosing is often used in the medical fields of endocrine and analgesia for treatment.

[0007] Taking the treatment of diabetes as an example, there are currently two methods for the treatment and control of diabetes: one is the conventional method of treatment, that is, 1-2 times of insulin injection and 1-2 times of blood glucose monitoring per day; the other is the intensive treatment method, which is multiple blood glucose monitoring per day, continuous infusion of insulin in a manner simulating the secretion of pancreatic islet cells, and making blood glucose as close to normal as possible. This method is mostly realized by using an insulin pump.

[0008] In 1993, the Diabetes Control and Complications Trial (DCCT) used the above two methods to carry out a large-scale long-term clinical trial to observe the benefits of intensive blood glucose control. The results showed that the average glycosylated hemoglobin of the good blood glucose control group decreased by 2% compared with the poor blood glucose control group, greatly reducing the risk of chronic complications of diabetes: the risk of diabetic eye disease decreased by about 76%, and the risk of kidney and neuropathy was also reduced to the same extent.

[0009] The existing Chinese patent application document with publication number CN113633850B discloses an automatic insulin injection device, which comprises an insulin pen, a protective sleeve for wrapping the needle is connected to the needle end of the insulin pen, a connecting device for automatic injection of the insulin pen and insertion of the needle into the patient's skin is arranged between the insulin pen injection push key and the protective sleeve. The automatic insulin injection device can automatically trigger the insertion of the needle into the subcutaneous fat of the patient to complete the insulin dose bolus injection.

[0010] The automatic insulin injection device in the prior art is difficult to accurately control the dose, has a complex structure, and has a high manufacturing cost, which needs to be improved. SUMMARY

[0011] Aiming at the defects in the prior art, the present application aims to provide a continuous micro-dosing device and an injection method.

[0012] The continuous micro-dosing device provided by the present application comprises a needle device, a drug storage device, a piston push rod device, a force storage device, a force storage release device and a control device; under the action of the control device, the force storage release device releases a specified piston stroke, the force storage device drives the piston push rod device to move into the drug storage device by a specified piston stroke, and the drug liquid in the drug storage device is discharged through the needle device.

[0013] Preferably, the force storage release device comprises a rotating magnetic brake assembly and a coupling assembly, the rotating magnetic brake assembly is electrically connected with the control device, the rotating magnetic brake assembly controls the piston stroke of the piston push rod device through the coupling assembly, and the force storage device outputs a rotating torque or a linear thrust force to the piston push rod device.

[0014] Preferably, the rotating magnetic brake assembly comprises a fixed coil and a rotating permanent magnet, the permanent magnet is radially magnetized, the magnetic field generated by the fixed coil interacts with the radial magnetic field of the permanent magnet to drive the permanent magnet to rotate or position, and an output gear is fixedly arranged on the permanent magnet; the force storage device comprises an elastic member, the elastic member is in a compressed state; the coupling assembly comprises a gear set, the output gear is engaged with a transmission starting gear of the gear set, a winding wheel is arranged on a transmission terminal gear of the gear set, a pull wire is wound on the winding wheel, and the pull wire extends to the piston push rod device along the extension direction of the elastic member and is connected with the piston push rod device through one end of the elastic member away from the piston push rod device.

[0015] Preferably, the rotating magnetic brake assembly comprises a fixed coil and a rotating permanent magnet, the permanent magnet is radially magnetized, the magnetic field generated by the fixed coil interacts with the radial magnetic field of the permanent magnet to drive the permanent magnet to rotate or position, and an output gear is fixedly arranged on the permanent magnet; the force storage device comprises a first torsional spring, the first torsional spring is in a compressed state; the coupling assembly comprises a gear set, the output gear is engaged with a transmission starting gear of the gear set, a worm is arranged on a transmission terminal gear of the gear set; the piston push rod device comprises a piston, a lead screw, a sleeve assembly and a worm wheel, the piston is arranged in the drug storage device, one end of the lead screw is fixedly connected with the piston body, the other end of the lead screw extends into the sleeve assembly and is threadedly connected with the inner wall of the sleeve assembly, the worm wheel is fixedly connected with the outer wall of the sleeve assembly, and the worm wheel is engaged with the worm; one end of the first torsional spring is fixedly connected with the sleeve assembly, and the other end of the first torsional spring is fixedly connected with the injection device housing.

[0016] Preferably, the sleeve assembly comprises a screw sleeve, a worm sleeve and a locking assembly, the screw sleeve extends into the worm sleeve, and the outer wall of the screw sleeve and the inner wall of the worm sleeve are in sliding fit along the axial direction of the sleeve assembly; the locking assembly fixedly connects the screw sleeve and the worm sleeve, the screw rod extends into the screw sleeve, and the worm wheel is arranged on the outer wall of the worm sleeve.

[0017] Preferably, the locking assembly comprises a locking steel ball and a locking clamping groove, the locking clamping groove is fixedly connected with the worm sleeve, and the screw sleeve extends into the worm sleeve through the locking clamping groove; the locking steel ball is arranged on the outer surface of the screw sleeve, the side of the locking clamping groove close to the locking steel ball is provided with a receiving groove with gradually decreasing diameter, and the locking steel ball is embeddedly fitted with the receiving groove.

[0018] Preferably, a safety valve is arranged on the connecting pipeline between the medicine storage device and the needle device, the safety valve comprises a valve body, a diaphragm and a sealing ring, the valve body is provided with a liquid outlet, and the liquid outlet is communicated with the needle device; the sealing ring and the diaphragm are sequentially arranged on the valve body, the liquid outlet is located in the middle of the sealing ring, and the side of the diaphragm away from the sealing ring is communicated with the medicine storage device; the diaphragm is provided with a liquid inlet hole, the sealing ring is provided with a flow limiting hole, and the valve body is provided with a flow guide groove, and the liquid inlet hole, the flow limiting hole and the flow guide groove are sequentially communicated; when the safety valve is in the open state, a liquid outlet cavity is formed between the diaphragm and the liquid outlet, and the flow guide groove is communicated with the liquid outlet cavity; when the safety valve is in the closed state, the diaphragm is attached to the liquid outlet.

[0019] Preferably, the needle device comprises a vertical needle seat, a rotating needle seat, a hard needle seat, a soft needle seat, a hard needle and a soft needle, the rotating needle seat is arranged in the vertical needle seat in a rotating and lifting mode; the outer wall of the rotating needle seat is provided with a rotating needle seat guide groove, the rotating needle seat guide groove extends downward from the upper end of the rotating needle seat to the lower end of the rotating needle seat, and then extends upward from the lower end of the rotating needle seat to the upper end of the rotating needle seat; the inner wall of the vertical needle seat is vertically provided with a vertical needle seat guide groove, the soft needle seat and the hard needle seat are sequentially arranged in the vertical needle seat guide groove from bottom to top, the soft needle seat is connected with the soft needle below, the hard needle seat is connected with the hard needle below, the hard needle sequentially passes through the soft needle seat and the soft needle from top to bottom, and the hard needle seat is arranged in the rotating needle seat guide groove in a sliding mode.

[0020] According to the injection method of the continuous micro-dosing device, the injection method comprises the following steps:

[0021] Step S1, injecting a sufficient amount of liquid medicine into the medicine storage device;

[0022] Step S2, the control device obtains an injection instruction or an injection program input from outside;

[0023] Step S3, the control device starts to control the force storage releasing device to release the specified piston stroke, the force storage device drives the piston push rod device to move into the medicine storage device by the specified piston stroke, and the quantitative injection is completed.

[0024] Preferably, for step S3, the following sub-steps are included:

[0025] Step S3.1, the control device converts the externally input injection instruction or injection program into a corresponding series of electric pulse signals and transmits the signals to the fixed coil;

[0026] Step S3.2, the fixed coil drives the permanent magnet to make corresponding movement to drive the output gear to rotate, and the worm gear is driven to rotate through the gear set, the lead screw sleeve moves into the worm gear sleeve, and the lead screw sleeve and the worm gear sleeve are locked until the locking steel ball is embedded into the accommodating groove of the locking slot;

[0027] Step S3.3, the control device acquires the locking signals of the lead screw sleeve and the worm gear sleeve, releases the piston stroke contained in the externally input injection instruction through the coil, the output gear and the gear set, and the quantitative injection is completed.

[0028] Compared with the prior art, the present application has the following beneficial effects:

[0029] 1. The present application uses the force storage device as a power source, drives the piston by rotation or direct pushing, calculates the required pulse number according to the required dose or the piston movement distance, and accurately controls the force storage releasing device to release the specified piston stroke through the control device, which helps to improve the accuracy of the drug dose.

[0030] 2. The coupling assembly composed of multiple gears connects the rotary magnetic brake assembly and the piston push rod device, and realizes the control of the larger force of the force storage device by the smaller force of the rotary magnetic brake assembly.

[0031] 3. The sleeve assembly enables the lead screw and the lead screw sleeve to move into the worm gear sleeve when the liquid medicine is injected into the medicine storage cavity, and the worm gear is locked with the lead screw sleeve and the worm gear sleeve by the locking assembly when the liquid is injected, which solves the problem that the worm gear sleeve and the lead screw sleeve need to be freely slid during charging and locked with each other during injection.

[0032] 4. The safety valve is used to suddenly increase the pressure of the diaphragm close to the medicine storage device under the limitation of the flow limiting hole when the coupling fails, deform the diaphragm to the liquid outlet side, cover the liquid outlet with the arc-shaped sealing surface of the sealing boss structure, close the liquid outlet, and prevent the liquid medicine from flowing out, which solves the safety problem when the equipment fails. BRIEF DESCRIPTION OF DRAWINGS

[0033] Other features, objects, and advantages of the application will become apparent from a reading of the detailed description of non-limiting embodiments thereof, taken in conjunction with the following drawings:

[0034] Figure 1 The schematic diagram of the overall structure of the injection device is mainly embodied in the present application;

[0035] Figure 2 The schematic diagram of the overall structure of the rotary magnetic brake assembly is mainly embodied in the present application;

[0036] Figure 3 The schematic diagram of the overall structure of the rotary magnetic brake assembly is mainly embodied in the present application;

[0037] Figure 4 The schematic diagram of the coupling assembly and the force storage device cooperation structure in embodiment one is mainly embodied in the present application;

[0038] Figure 5 The schematic diagram of the overall structure of the needle device is mainly embodied in the present application;

[0039] Figure 6 The schematic diagram of the needle seat structure of the needle device is mainly embodied in the present application;

[0040] Figure 7 The schematic diagram of the overall structure of the safety valve is mainly embodied in the present application;

[0041] Figure 8 The schematic diagram of the overall structure of the safety valve is mainly embodied in the present application;

[0042] Figure 9 The schematic diagram of the overall structure of the injection device in embodiment two is mainly embodied in the present application;

[0043] Figure 10 The schematic diagram of the overall structure of the locking assembly is mainly embodied in the present application;

[0044] Figure 11 The schematic diagram of the overall structure of the piston push rod device is mainly embodied in the present application.

[0045] The schematic diagram of the overall structure of the piston push rod device is mainly embodied in the present application.

[0046] The schematic diagram of the overall structure of the piston push rod device is mainly embodied in the present application.

[0047] The schematic diagram of the overall structure of the piston push rod device is mainly embodied in the present application.

[0048] The schematic diagram of the overall structure of the piston push rod device is mainly embodied in the present application.

[0049] The schematic diagram of the overall structure of the piston push rod device is mainly embodied in the present application.

[0050] Output gear 113 Worm sleeve 342 Control device 6

[0051] Magnetic sheet 114 Locking assembly 35 Circuit board 61

[0052] Limiting hole 115 Locking steel ball 351 Safety valve 7

[0053] Coupling assembly 12 Locking clamping groove 352 Valve body 71

[0054] Gear set 121 Containing groove 353 Diaphragm 72

[0055] Transmission starting gear 122 Locking trigger spring 354 Liquid inlet hole 721

[0056] Transmission end gear 123 Guide rod 36 Sealing ring 73

[0057] Winding wheel 124 Medicine storage device 4 Flow limiting hole 731

[0058] Pull wire 125 Medicine storage cavity 41 Liquid outlet 74

[0059] Worm 126 Needle device 5 Flow guide groove 75

[0060] Guide post 127 Vertical needle seat 51 Annular containing groove 76

[0061] Force storage device 2 Rotating needle seat 52 Sealing boss structure 77

[0062] Compression spring 21 Hard needle seat 53 Housing 8

[0063] First torsion spring 22 Soft needle seat 54 Sleeve locking signal switch 81 Piston push rod device 3 Hard needle 55 Guide seat 82

[0064] Piston body 31 Soft needle 56 DETAILED DESCRIPTION

[0065] The application will be described in detail below with specific embodiments. The following embodiments will help those skilled in the art to further understand the application, but do not limit the application in any form. It should be noted that those skilled in the art can make several changes and improvements without departing from the concept of the application. These are within the scope of the present application.

[0066] Example 1

[0067] As Figure 1As shown, according to the continuous micro-dosing device provided by the application, the device comprises a needle device 5, a drug storage device 4, a piston push rod device 3, a force storage device 2, a force storage release device 1 and a control device 6. Under the action of the control device 6, the force storage release device 1 releases a specified piston stroke, the force storage device 2 drives the piston push rod device 3 to move into the drug storage device 4 by a specified piston stroke, and the drug liquid in the drug storage device 4 is discharged through the needle of the needle device 5.

[0068] The specified piston stroke in the application is an infusion instruction issued by the staff through a Bluetooth communication or other information transmission mode to the control device 6. After receiving the infusion instruction, the control device 6 sends a corresponding electric pulse to the force storage release device 1 to release the specified piston stroke. The force storage device 2 can drive the piston push rod device 3 to move into the drug storage device 4 by the specified piston stroke, so as to squeeze the drug liquid in the drug storage device 4 and discharge the squeezed drug liquid through the needle of the needle device 5.

[0069] Specifically, the injection device further comprises a shell 8, which is the installation basis of the devices on the injection device and has a certain structural strength. The force storage release device 1 comprises a rotary magnetic brake assembly 11 and a coupling assembly 12. The rotary magnetic brake assembly 11 is electrically connected with the control device 6, and the rotary magnetic brake assembly 11 controls the piston stroke of the piston push rod device 3 through the coupling assembly 12. The force storage device 2 outputs a linear thrust to the piston push rod device 3.

[0070] As shown in Figure 1 , Figure 2 , Figure 3 More specifically, the rotary magnetic brake assembly 11 comprises a fixed coil 111 and a rotating permanent magnet 112. The permanent magnet 112 is radially magnetized. The magnetic field generated by the fixed coil 111 interacts with the radial magnetic field of the permanent magnet 112 to drive the permanent magnet 112 to rotate or position. An output gear 113 is fixedly arranged on the permanent magnet 112. The fixed coil 111 comprises a coil and a fixed support. The coil is arranged on the fixed support. The fixed support is fixedly installed on the shell 8 by fasteners. A magnetic conducting sheet 114 is also fixedly installed on the shell 8 by fasteners. The magnetic conducting sheet 114 is provided with a limiting hole 115 allowing the permanent magnet 112 to rotate and position. The permanent magnet 112 is in the shape of a cylinder. The cylindrical permanent magnet 112 is arranged in the limiting hole 115 and is rotatably installed on the shell 8 by a coaxially arranged rotating shaft. The magnetic conducting sheet 114 can be used to generate an alternating direction magnetic field. The magnetic field generated by the fixed coil 111 can interact with the magnetic field of the permanent magnet 112 to make the permanent magnet 112 rotate by a certain angle, especially one hundred and eighty degrees. The output gear 113 is coaxially and fixedly installed on the permanent magnet 112. The rotation of the permanent magnet 112 can drive the output gear 113 to rotate.

[0071] It should be noted that the rotating magnetic brake assembly 11 of the present application can also use the magnetic brake, electromagnetic swing fork or electromagnetic ring capable of outputting torque in the prior art.

[0072] The control device 6 comprises a circuit board 61, and a communication module, a data processing module, a data storage module and a signal conversion module are integrated on the circuit board 61. The signal conversion module and the communication module are electrically connected, and the circuit board 61 is electrically connected with the fixed coil 111. The communication module of the control device 6 can receive wired or wireless infusion instruction signals or infusion programs from the outside world. According to the received infusion information, the data processing module can automatically control the signal conversion module to generate corresponding electric pulse signals according to the needs. The electric pulse signals are transmitted to the fixed coil 111 to control the permanent magnet 112 to rotate by a certain angle, so as to realize the control of the rotation of the output gear 113 by a certain angle.

[0073] As shown in Figure 1 , Figure 2 , Figure 3 and Figure 4 , the coupling assembly 12 comprises a gear set 121, the gear set 121 comprises a plurality of meshing gear structures, any gear of the gear set 121 is rotationally connected with the housing 8 through a rotating shaft, and the gear set 121 comprises at least one transmission starting end gear 122 and at least one transmission end gear 123. The output gear 113 is engaged with the transmission starting end gear 122 of the gear set 121. At least one intermediate transmission gear is arranged between the transmission starting end gear 122 and the transmission end gear 123, the intermediate transmission gear is engaged with the transmission starting end gear 122 and another intermediate transmission gear, or is engaged with the transmission end gear 123 and another intermediate transmission gear, or is engaged with another two intermediate transmission gears.

[0074] The force storage device 2 comprises an elastic member, and the elastic member is in a compressed state. The elastic member of the present application outputs a linear thrust, which can be an elastic device capable of storing potential energy in the prior art, such as a compression spring 21, a rubber band, a compressed air spring, etc. The elastic member of the present application is preferably a compression spring 21.

[0075] The winding wheel 124 is coaxially arranged on the transmission end gear 123 of the gear set 121, and the pull wire 125 is wound on the winding wheel 124. The pull wire 125 extends to the piston push rod device 3 along the extension direction of the compression spring 21 away from one end of the piston push rod device 3 and is connected with the piston push rod device 3 through the compression spring 21. The gear set 121 can convert the rotation angle of the output gear 113 into the linear motion stroke of the pull wire 125 at a certain ratio. When the injection of the medicine is needed, the user sends a specific infusion instruction to the control device 6. After the control device 6 receives the specific infusion instruction, the control device 6 sends a corresponding electric pulse signal to the fixed coil 111, so that the permanent magnet 112 and the output gear 113 rotate by a certain angle. The output gear 113 releases a certain length of the pull wire 125 through the gear set 121, so as to realize the release of the specified piston stroke. At this time, the specified piston stroke is the same as the length of the released pull wire 125.

[0076] Further, the gear set 121 and the compression spring 21 are arranged side by side. The guide column 127 is arranged on the shell 8 and is arranged on the side of the compression spring 21 away from the piston push rod device 3. The pull wire 125 on the take-up wheel first passes through the guide column 127 and then extends to the piston push rod device 3 along the extension direction of the compression spring 21 away from one end of the piston push rod device 3 and is connected with the piston push rod device 3 through the compression spring 21.

[0077] The piston push rod device 3 comprises a piston body 31, and the medicine storage device 4 comprises a medicine storage cavity 41. The piston body 31 extends into the medicine storage cavity 41 and is in sliding connection with the inner wall of the medicine storage cavity 41. A dynamic seal is arranged between the piston body 31 and the inner wall of the medicine storage cavity 41, so as to prevent the medicine from leaking from the connection between the piston body 31 and the inner wall of the medicine storage cavity 41. The movement direction of the piston body 31 in the medicine storage cavity 41 is parallel to the extension direction of the compression spring 21. The compression spring 21 is connected or pressed with the piston body 31. Since the compression spring 21 is in a compressed state, it stores sufficient elastic potential energy. When the gear set 121 releases a certain length of the pull wire 125, the piston body 31 can move into the medicine storage cavity 41 by a certain length under the action of the compression spring 21. It should be noted that the cross-sectional area of the medicine storage cavity 41 can be determined during processing. When the piston body 31 moves into the medicine storage cavity 41 by a certain length, the volume of the medicine discharged by the piston body 31 can be calculated, so as to realize the quantitative infusion of the medicine and improve the accuracy of the infusion of the medicine.

[0078] With the help of gear set 121, the small force of rotating magnetic brake assembly 11 can be used to control the larger force of force storage device 2. Compared with servo motors and memory alloys, the cost of the technical solution of the application is greatly reduced, the required power consumption is one-tenth or even one percent, the cost of patients to purchase medical equipment can be greatly reduced, and battery consumption and pollution can be reduced.

[0079] As shown in Figure 5 and Figure 6 , the needle device 5 includes a vertical needle seat 51, a rotating needle seat 52, a hard needle seat 53, a soft needle seat 54, a hard needle 55, a soft needle 56, a second torsional spring 59, and a needle button 510. The vertical needle seat 51 is fixedly installed on the shell 8, the rotating needle seat 52, the second torsional spring 59 and the needle button 510 are coaxially arranged in the vertical needle seat 51 from bottom to top, the rotating needle seat 52 is rotationally arranged in the vertical needle seat 51, and the rotating needle seat 52 is rotationally connected with the inner wall of the vertical needle seat 51. The outer wall of the rotating needle seat 52 is provided with a rotating needle seat guide groove 57, which extends downward from the upper end of the rotating needle seat 52 to the lower end of the rotating needle seat 52, and then extends upward from the lower end of the rotating needle seat 52 to the upper end of the rotating needle seat 52. The lower end of the second torsional spring 59 is connected or pressed with the upper end of the rotating needle seat 52, and the upper end of the second torsional spring 59 is connected with the needle button 510. When the torsional spring is subjected to vertical pressure, it can drive the rotating needle seat 52 to rotate downward in the vertical direction.

[0080] The inner wall of the vertical needle seat 51 is vertically provided with a vertical needle seat guide groove 58, the soft needle seat 54 and the hard needle seat 53 are sequentially arranged in the vertical needle seat guide groove 58 from bottom to top, and the soft needle seat 54 and the hard needle seat 53 are both slidably connected with the vertical needle seat guide groove 58. The lower end of the soft needle seat 54 is connected with the soft needle 56, and the lower end of the hard needle seat 53 is connected with the hard needle 55. The hard needle 55 sequentially passes through the soft needle seat 54 and the soft needle 56 from top to bottom, and the hard needle seat 53 is slidably arranged in the rotating needle seat guide groove 57. It should be noted that the soft needle 56 is coaxially arranged outside the hard needle 55, and the hard needle 55 provides support for the soft needle 56 when it is inserted into the skin.

[0081] Pressing the needle button 510, the second torsional spring 59 pushes the rotating needle seat 52 to rotate downward, the hard needle seat 53 cannot move left and right under the limitation of the vertical needle seat guide groove 58, but can only slide in the rotating needle seat guide groove 57 and be pushed by the rotating needle seat guide groove 57 to move up and down in the vertical needle seat guide groove 58. When the rotating needle seat guide groove 57 rotates for a half turn, it pushes the hard needle seat 53, the hard needle 55, the soft needle seat 54 and the soft needle 56 to move downward together to insert the hard needle 55 and the soft needle 56 into the subcutaneous tissue. When the rotating needle seat guide groove 57 rotates for a half turn, it pushes the hard needle seat 53 to move upward to pull out the hard needle 55, and the soft needle 56 is left in the subcutaneous tissue.

[0082] The soft needle 56 is communicated with the medicine storage cavity 41 through a pipeline, and a safety valve 7 is arranged on the pipeline communicated between the medicine storage device 4 and the needle device 5, and the safety valve 7 is used for connecting or blocking the liquid passage between the medicine storage device 4 and the needle device 5.

[0083] As shown in the figure, the safety valve 7 comprises a valve body 71, a diaphragm 72 and a sealing ring 73, the valve body 71 is provided with a liquid outlet 74 communicated with the soft needle 56 of the needle device 5, the sealing ring 73 and the diaphragm 72 are sequentially arranged on the valve body 71, the liquid outlet 74 is located in the middle of the sealing ring 73, and the side of the diaphragm 72 away from the sealing ring 73 is communicated with the medicine storage device 4. Specifically, one side of the valve body 71 is provided with an annular accommodating groove 76, the liquid outlet 74 is coaxially arranged with the annular accommodating groove 76, the sealing ring 73 is embedded in the annular accommodating groove 76, and the diaphragm 72 is attached to the sealing ring 73. Figure 7 Figure 8 As shown in the figure, the safety valve 7 comprises a valve body 71, a diaphragm 72 and a sealing ring 73, the valve body 71 is provided with a liquid outlet 74 communicated with the soft needle 56 of the needle device 5, the sealing ring 73 and the diaphragm 72 are sequentially arranged on the valve body 71, the liquid outlet 74 is located in the middle of the sealing ring 73, and the side of the diaphragm 72 away from the sealing ring 73 is communicated with the medicine storage device 4. Specifically, one side of the valve body 71 is provided with an annular accommodating groove 76, the liquid outlet 74 is coaxially arranged with the annular accommodating groove 76, the sealing ring 73 is embedded in the annular accommodating groove 76, and the diaphragm 72 is attached to the sealing ring 73.

[0084] The diaphragm 72 is provided with an inlet hole 721, the sealing ring 73 is provided with a flow limiting hole 731, and the valve body 71 is provided with a flow guide groove 75, and the inlet hole 721, the flow limiting hole 731 and the flow guide groove 75 are sequentially communicated.

[0085] When the safety valve 7 is in the open state, the diaphragm 72 and the liquid outlet 74 form a liquid outlet cavity, and the flow guide groove 75 is communicated with the liquid outlet cavity. The liquid medicine in the medicine storage device 4 flows into the flow guide groove 75 through the inlet hole 721 on the diaphragm 72 and the flow limiting hole 731 on the sealing ring 73 in sequence. The middle part of the annular accommodating groove 76 of the valve body 71 is a sealing boss structure 77, the sealing boss structure 77 is circular, and the sealing boss structure 77 is gradually recessed from the circumferential edge to the middle part and forms a circular sealing surface, the gap between the circular sealing surface of the sealing boss structure 77 and the diaphragm 72 is the liquid outlet cavity, the flow guide groove 75 extends from the annular accommodating groove 76 into the sealing boss structure 77, and the liquid medicine in the medicine storage device 4 enters the liquid outlet cavity through the inlet hole 721, the flow limiting hole 731 and the flow guide groove 75 in sequence, and then enters the needle device 5 through the liquid outlet 74, so as to complete the injection of the liquid medicine.

[0086] When the coupling fails, due to the rapid pushing of the piston body 31, the pressure on the side of the diaphragm 72 close to the medicine storage device 4 suddenly increases under the action of the inlet hole 721 and the flow limiting hole 731, so that the diaphragm 72 deforms in the direction close to the liquid outlet 74 until the diaphragm 72 completely attaches to the circular sealing surface of the sealing boss structure 77. At this time, the diaphragm 72 attaches to the liquid outlet 74 and completely covers the liquid outlet 74, the safety valve 7 is in the closed state, and the liquid medicine cannot flow out.

[0087] Thus, when coupling assembly 12 fails, the restraint on the force storage mechanism is suddenly lost, piston body 31 is pushed at an extremely high speed, and the surface pressure of diaphragm 72 near drug storage device 4 increases suddenly under the restriction of flow restriction hole 731, causing diaphragm 72 to deform toward liquid outlet 74. The arc-shaped sealing surface of diaphragm 72, which contacts sealing boss structure 77, covers liquid outlet 74, sealing it and preventing the drug from flowing out. The use of thin film safety valve 7 solves the safety problem of equipment failure.

[0088] According to the present invention, an injection method of a continuous micro-dosing device is provided, and the injection method comprises the following steps:

[0089] Step S1: Fill a sufficient amount of liquid medicine into the medicine storage device 4.

[0090] Step S2: The control device 6 obtains an injection instruction or injection program input from the outside.

[0091] Step S3 , the control device 6 starts to control the force storage release device 1 to release the specified piston stroke, and the force storage device 2 pushes the piston push rod device 3 to move the specified piston stroke into the drug storage device 4 to complete the quantitative injection.

[0092] Specifically, before use, the continuous micro-dosing device is empty of liquid medicine. The user is required to inject the liquid medicine into the drug storage cavity 41 using a syringe. Therefore, a liquid injection hole is reserved on the sidewall of the drug storage cavity 41 at the end of the piston's extension stroke. During the injection of the liquid medicine into the drug storage cavity 41, the piston body 31 of the drug storage device moves backward as the liquid medicine is injected, compressing the compression spring 21 until a sufficient amount of liquid medicine is added to the drug storage cavity 41. When an injection is required, the user can send a specific infusion instruction to the control device 6 via Bluetooth communication or other means. Upon receiving the specific infusion instruction, the control device 6 sends a corresponding electric pulse signal to the fixed coil 111, causing the permanent magnet 112 and the output gear 113 to rotate a certain angle. The output gear 113 releases a certain length of the pull wire 125 via the gear set 121, thereby releasing the specified piston stroke. The specified piston stroke is now the same as the length of the release pull wire 125. The compressed compression spring 21 resets, pushing the piston push rod assembly 3 into the drug storage device 4 to move the specified piston stroke, completing the quantitative injection.

[0093] Example 2

[0094] Based on Example 1, Figure 9 、 Figure 10 as well as Figure 11As shown, according to the continuous micro-dosing device provided by the application, the application also proposes a feasible combination of the piston push rod device 3, the force storage device 2 and the force storage release device 1. The force storage release device 1 comprises a rotary magnetic brake assembly 11 and a coupling assembly 12. The rotary magnetic brake assembly 11 is electrically connected with the control device 6. The rotary magnetic brake assembly 11 controls the piston stroke of the piston push rod device 3 through the coupling assembly 12. The force storage device 2 outputs a rotary torque to the piston push rod device 3.

[0095] More specifically, the rotary magnetic brake assembly 11 comprises a fixed coil 111 and a rotationally arranged permanent magnet 112. The permanent magnet 112 is radially magnetized. The magnetic field generated by the fixed coil 111 interacts with the radial magnetic field of the permanent magnet 112 to push the permanent magnet 112 to rotate or position. An output gear 113 is fixedly arranged on the permanent magnet 112. The fixed coil 111 comprises a coil and a fixed support. The coil is arranged on the fixed support. The fixed support is fixedly installed on the housing 8 through fasteners. A magnetic conducting sheet 114 is also fixedly installed on the housing 8 through fasteners. The magnetic conducting sheet 114 is provided with a limiting hole 115 allowing the permanent magnet 112 to rotate and position. Through the shape of the limiting hole 115, the limiting hole can position the permanent magnet. The permanent magnet 112 is in the shape of a cylinder. The cylindrical permanent magnet 112 is placed in the limiting hole 115 and rotationally installed on the housing 8 through a coaxially arranged rotating shaft. The magnetic conducting sheet 114 can be used to generate a specific magnetic field, such as an alternating direction magnetic field. The magnetic field generated by the fixed coil 111 can interact with the magnetic field of the permanent magnet 112 to make the permanent magnet 112 rotate by a certain angle, especially one hundred and eighty degrees. The output gear 113 is coaxially and fixedly installed on the permanent magnet 112. The rotation of the permanent magnet 112 can drive the output gear 113 to rotate.

[0096] The control device 6 comprises a circuit board 61. The circuit board 61 is integrated with a communication module, a data processing module, a data storage module and a signal conversion module. The signal conversion module and the communication module are electrically connected. The circuit board 61 is electrically connected with the fixed coil 111. The communication module of the control device 6 can receive wired or wireless infusion instruction signals or infusion programs from the outside. According to the received infusion information, the data processing module can automatically control the signal conversion module to generate corresponding electric pulse signals according to the needs. The electric pulse signals are transmitted to the fixed coil 111 to control the permanent magnet 112 to rotate by a certain angle, so as to control the output gear 113 to rotate by a certain angle.

[0097] The coupling assembly 12 comprises a gear set 121, the gear set 121 comprising a plurality of meshed gear structures, any gear of the gear set 121 being rotatably connected with the housing 8 through a rotating shaft, and the gear set 121 comprising at least one transmission starting end gear 122 and at least one transmission ending end gear 123, the output gear 113 being meshed with the transmission starting end gear 122 of the gear set 121, and the transmission ending end gear 123 of the gear set 121 being provided with the worm 126. At least one intermediate transmission gear is provided between the transmission starting end gear 122 and the transmission ending end gear 123, the intermediate transmission gear being meshed with the transmission starting end gear 122 and another intermediate transmission gear respectively, or being meshed with the transmission ending end gear 123 and another intermediate transmission gear respectively, or being meshed with two other intermediate transmission gears respectively.

[0098] The force storage device 2 outputs a rotating torque, and comprises a first torsion spring 22 in a compressed state. The piston push rod device 3 comprises a piston body 31, a screw rod 32, a sleeve assembly 34, and a worm gear 33, the piston body 31 being arranged in the medicine storage device 4, one end of the screw rod 32 being fixedly connected with the piston body 31, the other end of the screw rod 32 extending into the sleeve assembly 34 and being threadedly connected with the inner wall of the sleeve assembly 34, and the worm gear 33 being fixedly connected with the outer wall of the sleeve assembly 34 and being meshed with the worm 126. One end of the first torsion spring 22 is fixedly connected with the sleeve assembly 34, and the other end of the first torsion spring 22 is fixedly connected with the housing 8 of the injection device.

[0099] Further, the sleeve assembly 34 comprises a screw rod sleeve 341, a worm gear sleeve 342, and a locking assembly 35, the screw rod sleeve 341 extending into the worm gear sleeve 342, and the outer wall of the screw rod sleeve 341 being slidingly fitted with the inner wall of the worm gear sleeve 342 along the axial direction of the sleeve assembly 34. The locking assembly 35 fixedly connects the screw rod sleeve 341 and the worm gear sleeve 342. Before the locking assembly 35 fixedly connects the screw rod sleeve 341 and the worm gear sleeve 342, the screw rod sleeve 341 can slide along the axial direction of the sleeve assembly 34 relative to the worm gear sleeve 342, and after the locking assembly 35 fixedly connects the screw rod sleeve 341 and the worm gear sleeve 342, the screw rod sleeve 341 and the worm gear sleeve 342 do not move relative to each other.

[0100] The locking assembly 35 comprises a locking steel ball 351 and a locking clamping groove 352, the locking clamping groove 352 is fixedly connected with the worm sleeve 342, the screw sleeve 341 passes through the locking clamping groove 352 and extends into the worm sleeve 342. The locking steel ball 351 is arranged on the outer surface of the screw sleeve 341, and the locking clamping groove 352 is provided with a receiving groove 353 with a gradually decreasing diameter on the side close to the locking steel ball 351, and the locking steel ball 351 is embeddedly matched with the receiving groove 353. The receiving groove 353 is formed by the cooperation of the inner wall of the locking clamping groove 352 and the outer wall of the screw sleeve 341, and the cross-sectional shape of the receiving groove 353 is approximately "V" type. When the locking steel ball 351 enters the locking clamping groove 352 by a certain distance to reach a gap smaller than the diameter of the locking steel ball 351, the locking steel ball 351, the locking clamping groove 352 and the screw sleeve 341 are mutually clamped, and the screw sleeve 341 and the worm sleeve 342 are mutually locked.

[0101] Further, the locking trigger spring 354 is coaxially sleeved on the screw sleeve 341, the locking trigger spring 354 is arranged on the side of the locking steel ball 351 away from the locking clamping groove 352, and the locking trigger spring 354 is provided with a semicircular groove embeddedly matched with the locking steel ball 351. The locking steel ball 351 is arranged at equal intervals around the central axis of the screw sleeve 341 on the circumferential side of the screw sleeve 341, and the semicircular groove on the locking trigger spring 354 is correspondingly arranged with the locking steel ball 351. The sleeve locking signal switch 81 is arranged on the shell 8.

[0102] Before use, there is no drug liquid in the drug storage device 4, and the user needs to inject the drug liquid into the drug storage cavity 41 using the syringe. At this time, the piston body 31 will move backward with the injection of the drug liquid, and the screw rod 32 and the screw sleeve 341 connected with the piston body 31 need to freely slide in the worm sleeve 342. When the injection of the drug begins, the worm sleeve 342 and the screw sleeve 341 must be locked and cannot freely slide to push the piston body 31 forward by the screw rod 32 to inject the drug liquid.

[0103] When the turbine starts to rotate during injection, the locking trigger spring 354 rotates with the turbine, and when the locking trigger spring 354 rotates to the position where the sleeve locking signal switch 81 cannot block the locking trigger spring 354, the locking trigger spring 354 pushes the locking steel ball 351 into the locking clamping groove 352. The gap between the locking clamping groove 352 and the screw sleeve 341 is V-shaped, and the gap between the locking clamping groove 352 and the screw sleeve 341 becomes smaller as it goes to the inside of the locking clamping groove 352. When the locking steel ball 351 enters the locking clamping groove 352 by a certain distance to reach a gap smaller than the diameter of the locking steel ball 351, the locking steel ball 351, the locking clamping groove 352 and the screw sleeve 341 are mutually clamped, and the screw sleeve 341 and the worm sleeve 342 are mutually locked. In this way, the problem that the worm sleeve 342 and the screw sleeve 341 need to freely slide during drug filling and be locked during injection is solved.

[0104] Further, the piston body 31 is further fixedly provided with a guide rod 36, the length direction of the guide rod 36 is parallel to the length direction of the screw rod 32, the housing 8 is provided with a guide seat 82, the guide rod 36 horizontally passes through the guide seat 82 and is in sliding fit with the guide seat 82.

[0105] According to the injection method of the continuous micro-dosing device, the injection method comprises the following steps:

[0106] Step S1, injecting a sufficient amount of liquid medicine into the medicine storage device 4.

[0107] Step S2, the control device 6 obtains the injection instruction or injection program inputted from outside.

[0108] Step S3, the control device 6 starts to control the force storage and release device 1 to release the specified piston stroke, the force storage device 2 drives the piston push rod device 3 to move into the medicine storage device 4 by the specified piston stroke, and the quantitative injection is completed.

[0109] Step S3, comprising the following sub-steps:

[0110] Step S3.1, the control device 6 converts the injection instruction or injection program inputted from outside into a series of corresponding electric pulse signals and transmits the electric pulse signals to the fixed coil.

[0111] Step S3.2, the fixed coil 111 drives the permanent magnet 112 to make corresponding movement to make the output gear 113 rotate, and drives the worm wheel 33 to rotate through the gear set 121, the screw rod sleeve 341 moves into the worm wheel sleeve 342, until the locking steel ball 351 is embedded into the containing groove 353 of the locking slot 352 to lock the screw rod sleeve 341 and the worm wheel sleeve 342.

[0112] Step S3.3, the control device 6 acquires the locking signals of the screw rod sleeve 341 and the worm wheel sleeve 342, releases the piston stroke contained in the injection instruction inputted from outside through the coil, the output gear 113 and the gear set 121, and completes the quantitative injection.

[0113] When initially installed, the force storage release device 1, the force storage device 2 and the piston push rod device 3 are installed in place, coupled and static, and the piston is lifted to the top of the medicine storage cavity 41. The user fills the medicine storage cavity 41 with insulin through the filling hole by means of the syringe, and the piston body 31 retreats under force, triggering the power switch to turn on the circuit. After filling, the user issues an infusion instruction through the controller in a Bluetooth communication mode, and the control device 6 receives the instruction and sends out a corresponding electric pulse. The rotating magnetic brake assembly 11 is angularly offset under the electric pulse, and the output gear 113 also rotates by a corresponding angle. The coupling mechanism transmits the corresponding angle, and the locking assembly 35 locks the screw sleeve 341 and the turbine sleeve 342 to enable the force storage device 2 to push the piston body 31 to move correspondingly. The squeezed liquid flows out through the soft needle 56 needle.

[0114] In the description of the present application, it should be understood that the terms "upper", "lower", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer" and the like indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the devices or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as limiting the present application.

[0115] The specific embodiments of the present application are described above. It should be understood that the present application is not limited to the above specific embodiments, and those skilled in the art can make various changes or modifications within the scope of the claims, which does not affect the essential content of the present application. In the case of no conflict, the embodiments of the present application and the features in the embodiments can be combined with each other arbitrarily.

Claims

1. A continuous micro-dosing device, characterized in that: It comprises a needle device (5), a medicine storage device (4), a piston push rod device (3), a force storage device (2), a force storage release device (1) and a control device (6); Under the action of the control device (6), the force storage release device (1) releases a specified piston stroke, the force storage device (2) pushes the piston push rod device (3) to move the specified piston stroke into the medicine storage device (4), and the medicine liquid in the medicine storage device (4) is discharged through the needle device (5); The force storage release device (1) comprises a rotating magnetic brake assembly (11) and a coupling assembly (12); the rotating magnetic brake assembly (11) is electrically connected to a control device (6); the rotating magnetic brake assembly (11) controls the piston stroke of a piston push rod device (3) through the coupling assembly (12); and the force storage device (2) outputs a rotational torque or a linear thrust to the piston push rod device (3); The rotating magnetic brake assembly (11) comprises a fixed coil (111) and a rotatably arranged permanent magnet (112), wherein the permanent magnet (112) is radially magnetized, and the magnetic field generated by the fixed coil (111) interacts with the radial magnetic field of the permanent magnet (112) to drive the permanent magnet (112) to rotate or position, and an output gear (113) is fixedly arranged on the permanent magnet (112); The force storage device (2) comprises a first torsion spring (22), wherein the first torsion spring (22) is in a compressed state; The coupling assembly (12) includes a gear set (121), the output gear (113) meshes with a transmission start-end gear (122) of the gear set (121), and a worm (126) is provided on the transmission end gear (123) of the gear set (121); The piston push rod device (3) comprises a piston body (31), a screw rod (32), a sleeve assembly (34) and a worm gear (33); the piston body (31) is arranged in the medicine storage device (4); one end of the screw rod (32) is fixedly connected to the piston body (31); the other end of the screw rod (32) extends into the sleeve assembly (34) and is threadedly connected to the inner wall of the sleeve assembly (34); the worm gear (33) is fixedly connected to the outer wall of the sleeve assembly (34); and the worm gear (33) is meshed with the worm (126); One end of the first torsion spring (22) is fixedly connected to the sleeve assembly (34), and the other end of the first torsion spring (22) is fixedly connected to the housing (8).

2. The continuous micro-dosing device according to claim 1, wherein The sleeve assembly (34) comprises a screw sleeve (341), a worm gear sleeve (342) and a locking assembly (35); the screw sleeve (341) extends into the worm gear sleeve (342), and the outer wall of the screw sleeve (341) and the inner wall of the worm gear sleeve (342) are slidably matched along the axial direction of the sleeve assembly (34); The locking assembly (35) fixedly connects the screw sleeve (341) and the worm gear sleeve (342); the screw (32) extends into the screw sleeve (341); and the worm gear (33) is arranged on the outer wall of the worm gear sleeve (342).

3. The continuous micro-dosing device according to claim 2, wherein: The locking assembly (35) includes a locking steel ball (351) and a locking slot (352), wherein the locking slot (352) is relatively fixedly connected to the worm gear sleeve (342), and the screw sleeve (341) passes through the locking slot (352) and extends into the worm gear sleeve (342); The locking steel ball (351) is arranged on the outer surface of the screw sleeve (341), and a receiving groove (353) with a gradually decreasing diameter is provided on the side of the locking slot (352) close to the locking steel ball (351), and the locking steel ball (351) is embedded and matched with the receiving groove (353).

4. The continuous micro-dosing device according to claim 1, wherein A safety valve (7) is provided on the communication pipeline between the drug storage device (4) and the needle device (5), and the safety valve (7) comprises a valve body (71), a diaphragm (72) and a sealing ring (73). The valve body (71) is provided with a liquid outlet (74), and the liquid outlet (74) is communicated with the needle device (5); The sealing ring (73) and the diaphragm (72) are sequentially arranged on the valve body (71), the liquid outlet (74) is located in the middle of the sealing ring (73), and the side of the diaphragm (72) facing away from the sealing ring (73) is in communication with the drug storage device (4); The diaphragm (72) is provided with a liquid inlet hole (721), the sealing ring (73) is provided with a flow limiting hole (731), and the valve body (71) is provided with a flow guide groove (75), and the liquid inlet hole (721), the flow limiting hole (731) and the flow guide groove (75) are sequentially connected; When the safety valve (7) is in an open state, a liquid outlet cavity is formed between the diaphragm (72) and the liquid outlet (74), and the guide groove (75) is in communication with the liquid outlet cavity; When the safety valve (7) is in a closed state, the diaphragm (72) seals the liquid outlet (74).

5. The continuous micro-dosing device according to claim 1, wherein The needle device (5) comprises a vertical needle seat (51), a rotating needle seat (52), a hard needle seat (53), a soft needle seat (54), a hard needle (55) and a soft needle (56), wherein the rotating needle seat (52) is arranged in the vertical needle seat (51) for rotation and lifting; A rotating needle seat guide groove (57) is provided on the outer wall of the rotating needle seat (52), and the rotating needle seat guide groove (57) spirally extends downward from the upper end of the rotating needle seat (52) to the lower end of the rotating needle seat (52), and then spirally extends upward from the lower end of the rotating needle seat (52) to the upper end of the rotating needle seat (52); A vertical needle seat guide groove (58) is vertically provided on the inner wall of the vertical needle seat (51), and the soft needle seat (54) and the hard needle seat (53) are slidably arranged in the vertical needle seat guide groove (58) from bottom to top in sequence. A soft needle (56) is connected to the bottom of the soft needle seat (54), and a hard needle (55) is connected to the bottom of the hard needle seat (53). The hard needle (55) passes through the soft needle seat (54) and the soft needle (56) in sequence from top to bottom, and the hard needle seat (53) is slidably arranged in the rotating needle seat guide groove (57).

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