Chemiluminescence immunoassay analyzer reaction cup automatic management cup loading device and control method

Abstract

The application discloses a kind of chemiluminescence immunoassay analyzer reaction cup automatic sorting cup loading device and control method, belong to the technical field of immunological analysis equipment automation, comprising: funnel-shaped reaction cup stock bin: located in the upper portion of device, for storing reaction cup;Rotary disturbance mechanism: suspended in the interior of stock bin, its rotation axis is coaxial with the bottom round table and bottom round hole of stock bin, for disturbing reaction cup and making it orderly fall;Order loading module: be set below stock bin, for receiving the reaction cup of falling and making it in slide way sequentially arranged;Push cup isolation module: be set in order loading module terminal, for the reaction cup of last end of slide way and the rest reaction cup isolation;Support platform: located in the side of device, for fixing and limiting each module.The application can realize reaction cup automatic, efficient, orderly sorting cup and loading, improve the detection efficiency and stability of chemiluminescence immunoassay analyzer, applicable to high-throughput detection scene.

Description

Technical Field

[0001] This invention belongs to the field of automation technology for immunoassay equipment, specifically relating to an automatic cup loading device and control method for a chemiluminescence immunoassay analyzer reaction cups. Background Technology

[0002] Chemiluminescence immunoassay analyzers are widely used in clinical immunology testing, tumor marker screening, thyroid function assessment, myocardial injury marker determination, and antibody / antigen detection of infectious pathogens, providing precise data support for early disease diagnosis, treatment monitoring, and epidemiological surveys. The reaction cups in a chemiluminescence immunoassay analyzer are key consumables that carry out antigen-antibody reactions and the chemiluminescence process. The automated reaction cup loading function, through the coordinated operation of a mechanical structure and control system, automates the process of moving reaction cups from a stacked state to an ordered single-cup output. After loading, the reaction cups can be gripped by claws, achieving seamless integration with sample addition and reaction processes. The automated reaction cup loading function of a chemiluminescence immunoassay analyzer needs to continuously supply hundreds to thousands of reaction cups, adapting to automated batch use in high-throughput testing scenarios.

[0003] Currently, the main methods for automated reaction cup loading and unloading in chemiluminescence immunoassay analyzers are as follows:

[0004] One type is a tracked cup-retrieval structure, which consists of several cup-retrieval blocks or pick-up blocks spaced apart on a conveyor chain or synchronous belt drive structure. The cup-retrieval blocks or pick-up blocks retrieve or pick up the reaction cups one by one, and then sort and load them (such as an automatic reaction cup loading device with patent publication number CN108845155A, and an automatic reaction cup loading device and sample analyzer with patent publication number CN111033268A). This type of loading device has a complex structure, large size, high cost, and high failure rate.

[0005] One type is a disc-type cup-collecting structure, which consists of several cup-collecting fingers or lifting blocks and cup-dispensing protrusions or stirring blocks spaced apart on the rotating disk drive structure. The cup-collecting fingers or lifting blocks pick up the reaction cups one by one, and the cup-dispensing protrusions or stirring blocks can improve the picking efficiency (such as an automatic cup loading device based on a chemiluminescence immunoassay analyzer with patent publication number CN208026755U, and an automatic continuous loading device for reaction cups with patent publication number CN114414825A). This type of loading device has a complex structure and large volume. In addition, the rotating disk is vertical, and the cup-collecting or cup-dispensing components on it interact with the disorderly stacked reaction cups in the hopper during the downward movement, which can easily cause the reaction cups to be squeezed and jammed.

[0006] Another type is the pusher-type cup retrieval structure, which uses a pusher plate that slides up and down in the accommodating cavity to push out the reaction cups one by one for sorting and loading (such as the feeding device with patent publication number CN112811206A). This type of loading device has low cup retrieval efficiency, especially when there are few reaction cups in the hopper. When there are many reaction cups in the hopper, multiple reaction cups may be pushed out at the same time, causing the reaction cups to get stuck in the channel.

[0007] Therefore, there is a need for a device that is compact, low-cost, has a low failure rate, and can efficiently and stably achieve continuous automatic loading of reaction vessels. Summary of the Invention

[0008] In view of the above, the purpose of this invention is to provide an automatic reaction cup loading device and control method for a chemiluminescence immunoassay analyzer. By setting up a funnel-shaped reaction cup hopper to achieve centralized storage of reaction cups, a rotating disturbance mechanism to make the reaction cups fall in an orderly manner, a sorting loading module to arrange the reaction cups in sequence, and a cup pushing isolation module to accurately isolate individual reaction cups, so as to achieve automatic, efficient, and orderly cup loading and sorting, improve the detection efficiency and stability of the chemiluminescence immunoassay analyzer, and be suitable for high-throughput detection scenarios.

[0009] To achieve the above-mentioned objectives, the present invention provides the following technical solution:

[0010] An automatic reaction cup loading device for a chemiluminescence immunoassay analyzer is provided in this embodiment of the invention, comprising: a funnel-shaped reaction cup hopper, a rotating disturbance mechanism, a sorting and loading module, a cup pushing and isolation module, and a support platform;

[0011] The funnel-shaped reaction cup hopper is located at the top of the device and is used to store the reaction cups;

[0012] The rotating disturbance mechanism is suspended inside the funnel-shaped reaction cup hopper, and its rotation axis is coaxial with the bottom frustum and bottom circular hole of the funnel-shaped reaction cup hopper, which is used to disturb the reaction cup so that it falls in an orderly manner.

[0013] The sorting and loading module is located below the funnel-shaped reaction cup hopper and is used to receive the reaction cups falling from the funnel-shaped reaction cup hopper and arrange them in sequence in the slide.

[0014] The pusher cup isolation module is located at the end of the sorting and loading module and is used to isolate the reaction cup at the end of the slide in the sorting and loading module from the other reaction cups.

[0015] The support platform is located on the side of the device and is used to fix and limit the funnel-shaped reaction cup hopper, the rotating disturbance mechanism, the sorting and loading module, and the cup pushing isolation module.

[0016] Preferably, the funnel-shaped reaction cup hopper includes a top cover, a cup inlet, a storage compartment, a bottom frustum hole, a bottom circular hole, and a bottom slot;

[0017] The top cover includes a fixed part and an opening and closing part. The fixed part is provided with an opening to avoid the rotation disturbance mechanism, and the opening and closing part is used to close or open the cup inlet.

[0018] The storage compartment is located below the top cover and the inlet of the reaction cups and is used to store a certain number of reaction cups;

[0019] The bottom frustum hole is located below the storage compartment, and its frustum inclination angle is adapted to the shape of the reaction cup;

[0020] The bottom circular hole is located below the bottom frustum hole and includes three sections: upper, middle and lower. The upper section circular hole is connected to the bottom frustum hole and transitions through an arc surface. The middle section circular hole and the lower section circular hole are both straight holes with a fixed diameter that is adapted to the size and shape of the reaction cup. The middle section circular hole and the lower section circular hole have a smooth transition.

[0021] The bottom slot is used to engage and fix with the sorting and loading module.

[0022] Preferably, the frustum angle of the bottom frustum hole is 40-50 degrees, and more preferably 45 degrees.

[0023] Preferably, the diameter of the middle section of the bottom circular hole is 2 to 3 times the outer diameter of the reaction cup body, the sum of the heights of the upper and middle sections of the circular hole should be less than the height of the reaction cup body, and the diameter of the lower section of the circular hole is 1 to 1.5 times the diameter of the reaction cup flange.

[0024] Preferably, the rotating disturbance mechanism includes a rotating disturbance rod, a drive motor, and a motor mounting base;

[0025] The upper end of the rotating disturbance rod is connected to the drive motor shaft, and the lower end is forked into a rod with an included angle, with the end of the rod bending inward.

[0026] The drive motor is used to drive the rotating disturbance rod to rotate around the axis and control the rotation angle, rotation speed, rotation acceleration and rotation direction of the rotating disturbance rod;

[0027] The motor mounting base is fixedly connected to the support platform to fix the drive motor and ensure that the rotating disturbance mechanism is suspended inside the reaction cup hopper.

[0028] Preferably, the lower end of the rotating disturbance rod is forked into two rods, with the two rods forming an angle of 45 to 55 degrees, preferably 50 degrees.

[0029] Preferably, the sorting and loading module includes a slide plate, a connecting block, and a baffle.

[0030] The slide plate and connecting block are used to construct the slide. The slide is inclined at an angle of 15 to 20 degrees with the horizontal direction, preferably 15 degrees. The width of the slide is greater than the diameter of the reaction cup body and less than the diameter of the reaction cup flange. The depth of the slide is greater than the height of the reaction cup body. The end of the slide has a horizontal section with a length less than the diameter of the reaction cup.

[0031] The baffle is located on the outside of the slide to prevent the reaction cup from coming off.

[0032] Preferably, the cup-pushing isolation module includes an electric push rod, a lever, and a mounting base;

[0033] The electric push rod moves in a direction perpendicular to the slide rail and is used to extend or retract the lever.

[0034] The lever is fixed to the end of the electric push rod, and its front end forms an angle of 25 to 35 degrees with the direction of push rod movement, preferably 30 degrees, for using to push the reaction cup upward when extended;

[0035] The mounting base is fixed to the support platform and is used to fix the electric push rod and guide the lever.

[0036] Preferably, the funnel-shaped reaction cup hopper is equipped with at least one photoelectric detection sensor located at different heights of the funnel-shaped reaction cup hopper for monitoring the amount of reaction cups stored; the sorting and loading module is also equipped with a photoelectric detection sensor located on the side of the sorting and loading module for detecting the number of reaction cups in the chute.

[0037] To achieve the above-mentioned objectives, this invention also provides a control method for the automatic cup loading device for a chemiluminescence immunoassay analyzer, as described above, comprising the following steps:

[0038] S1, the reaction cups stored in the funnel-shaped reaction cup hopper are continuously agitated by the rotating disturbance mechanism to promote their orderly falling;

[0039] S2, receives reaction cups through the sorting loading module and arranges them sequentially in the slide;

[0040] S3, the push cup isolation module isolates the reaction cup at the end of the slide in the sorting loading module from the other reaction cups, making it easier for the gripper of the chemiluminescence immunoassay analyzer to grab the reaction cup at the end.

[0041] S4 monitors the number of reaction cups in the funnel-shaped reaction cup hopper and chute using photoelectric detection sensors, and provides feedback to control the operation of the rotating disturbance mechanism and the cup pushing isolation module.

[0042] Compared with the prior art, the beneficial effects of the present invention include at least the following:

[0043] (1) The device has a simple structure: the funnel-shaped reaction cup hopper and the inverted Y-shaped rotating disturbance mechanism can realize the automatic falling of a single reaction cup. The reaction cup can automatically adjust its posture and arrange its order when it falls into the slide. There are no complicated structures such as cup scooping, cup flipping, and conveying.

[0044] (2) The device is easy to operate: the reaction cups can be automatically dropped by controlling the rotating disturbance mechanism to drive the motor to rotate. After the reaction cups are dropped, they automatically adjust their posture and slide down by their own gravity, so that the reaction cups in the slide are arranged in order. There is no need to detect and control the attitude of the reaction cups when they are dropped.

[0045] (3) High cup sorting efficiency: All reaction cups that automatically fall from the reaction cup hopper enter the chute for sorting and loading, eliminating the need for screening based on the falling posture of the reaction cups and improving the cup sorting efficiency. Furthermore, the frequency of automatic falling of reaction cups from the hopper is not affected by the number of cups in the hopper, and the cup sorting efficiency will not decrease as the number of reaction cups in the hopper decreases. At the same time, the rotating disturbance mechanism can actively agitate the reaction cups in the reaction cup hopper, avoiding the impact on the cup sorting efficiency due to the reaction cups piling up and not moving.

[0046] (4) Fewer cup handling failures: The rotating disturbance rod of the rotating disturbance mechanism is suspended in the reaction cup hopper and rotates horizontally. It only pushes the reaction cup in the horizontal direction, avoiding the occurrence of failures such as jamming of the moving mechanism or squeezing and flying of the reaction cup due to the vertical contact of the moving mechanism such as cup scooping with the reaction cup. Attached Figure Description

[0047] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0048] Figure 1 This is a schematic diagram of the automatic cup loading device for the chemiluminescence immunoassay analyzer provided in this embodiment of the invention;

[0049] Figure 2 This is a side view of the automatic cup loading device for the chemiluminescence immunoassay analyzer provided in an embodiment of the present invention;

[0050] Figure 3 This is a cross-sectional view of the funnel-shaped reaction cup silo provided in an embodiment of the present invention;

[0051] Figure 4 This is a schematic diagram of the rotating disturbance mechanism provided in an embodiment of the present invention;

[0052] Figure 5 This is a schematic diagram of the sorting and loading module provided in an embodiment of the present invention;

[0053] Figure 6 This is a top view of the automatic cup loading device for the chemiluminescence immunoassay analyzer provided in this embodiment of the invention;

[0054] Figure 7 This is a flowchart illustrating the control method of the automatic cup loading device for the chemiluminescence immunoassay analyzer provided in this embodiment of the invention.

[0055] The specific symbols in the accompanying drawings and embodiments are as follows:

[0056] 1. Funnel-shaped reaction cup hopper; 11. Top cover; 12. Cup inlet; 13. Storage hopper; 14. Bottom frustum hole; 15. Bottom round hole; 151. Upper round hole; 152. Middle round hole; 153. Lower round hole; 16. Bottom slot; 17. Funnel-shaped reaction cup hopper photoelectric detection sensor; 2. Rotary disturbance mechanism; 21. Rotary disturbance rod; 22. Drive motor; 23. Motor mounting base; 3. Sorting loading module; 31. Slide plate I; 32. Slide plate II; 33. Connecting block I; 34. Connecting block II; 35. Baffle I; 36. Baffle II; 37. Baffle III; 38. Sorting loading module photoelectric detection sensor; 4. Cup pushing isolation module; 41. Electric push rod; 42. Toggle rod; 43. Mounting base; 5. Support platform. Detailed Implementation

[0057] To make the objectives, technical solutions, and advantages of this invention clearer, the invention will be further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and do not limit the scope of protection of this invention.

[0058] The inventive concept of this invention is to address the problems of complex cup handling methods, low efficiency of cup retrieval mechanisms, and easy cup jamming during the loading process of reaction cups in chemiluminescence immunoassay analyzers. This invention provides an automatic cup handling and loading device and control method for chemiluminescence immunoassay analyzers. Through the coordinated operation of a funnel-shaped reaction cup storage bin, a rotating disturbance mechanism controlling orderly descent, an automatic cup sorting module, and a precise isolation module, the automatic cup handling and loading function of reaction cups can be achieved efficiently and stably. The device has a simple structure and a convenient control method, and can meet the requirements of high-throughput detection.

[0059] like Figure 1 and Figure 2As shown, this embodiment provides an automatic reaction cup loading device for a chemiluminescence immunoassay analyzer, including a funnel-shaped reaction cup hopper 1, a rotating disturbance mechanism 2, a sorting and loading module 3, a cup-pushing isolation module 4, and a support platform 5. The funnel-shaped reaction cup hopper 1 is positioned above the sorting and loading module 3, with its bottom fixedly connected to one end of the module 3. The rotating disturbance mechanism 2 is suspended inside the funnel-shaped reaction cup hopper 1, and its rotation axis is coaxial with the bottom frustum hole 14 and bottom circular hole 15 of the funnel-shaped reaction cup hopper 1. The cup-pushing isolation module 4 is fixedly connected to the other end of the sorting and loading module 3. The funnel-shaped reaction cup hopper 1 and the rotating disturbance mechanism 2 are fixed and confined to the upper part of the device by the support platform 5; the sorting and loading module 3 and the cup-pushing isolation module 4 are fixed and confined to the lower part of the device by the support platform 5. The funnel-shaped reaction cup hopper 1 is used to store reaction cups and, in conjunction with the rotating disturbance mechanism 2, completes the automatic descent of a single reaction cup. The sorting and loading module 3 receives reaction cups falling from the funnel-shaped reaction cup hopper 1, and allows the falling reaction cups to automatically adjust their posture and slide down under their own gravity, thus arranging the reaction cups in sequence within the chute. The cup-pushing isolation module 4 isolates the last reaction cup at the end of the chute from the other reaction cups by a distance, allowing the grippers of the chemiluminescence immunoassay analyzer to grasp the last reaction cup without obstruction. The support platform 5 fixes the funnel-shaped reaction cup hopper 1, the rotating disturbance mechanism 2, the sorting and loading module 3, and the cup-pushing isolation module 4, and defines their relative positions.

[0060] Specifically, such as Figure 3As shown, the funnel-shaped reaction cup hopper 1 consists of a top cover 11, a cup inlet 12, a storage compartment 13, a bottom frustum-shaped hole 14, a bottom circular hole 15, and a bottom slot 16. The top cover 11 is located at the top of the funnel-shaped reaction cup hopper 1 and is used to close the opening above the funnel-shaped reaction cup hopper 1 to prevent the reaction cups from overflowing. The top cover 11 is divided into a fixed part and an opening / closing part. The fixed part is fixedly connected to the funnel-shaped reaction cup hopper 1 and has an opening to avoid the rotational disturbance mechanism 2; the opening / closing part is movable and used to close or open the cup inlet 12 above the funnel-shaped reaction cup hopper 1. Below the top cover 11 and the cup inlet 12 of the funnel-shaped reaction cup hopper 1 is the storage compartment 13, which is used to store a certain number of reaction cups. Its size and shape can be determined according to the number of reaction cups that the chemiluminescence immunoassay analyzer needs to store and the spatial layout of the instrument. Below the storage compartment 13 is a bottom frustum hole 14, the frustum angle of which is a fixed value and adapted to the size and shape of the reaction cup, preferably 45 degrees; the diameter of its bottom surface is a fixed value and adapted to the size and shape of the reaction cup. Below the bottom frustum hole 14 is the bottom circular hole 15, which is divided into three sections: upper, middle, and lower. The upper circular hole 151 connects to the bottom frustum hole 14 and transitions with an arc surface. The middle circular hole 152 is a straight hole with a fixed diameter that matches the size and shape of the reaction cup, preferably 2 to 3 times the outer diameter of the reaction cup body. The sum of the heights of the upper circular hole 151 and the middle circular hole 152 should be less than the height of the reaction cup body, so that part of the reaction cup body that has not fallen is located in the bottom frustum hole 14, and the rotating disturbance mechanism 2 can disturb and change its posture. The lower circular hole 153 is a straight hole with a fixed diameter that matches the size and shape of the reaction cup, preferably 1 to 1.5 times the diameter of the reaction cup flange. The middle circular hole 152 and the lower circular hole 153 should have a smooth transition. The bottom slot 16 cooperates with the sorting and loading module 3 for clamping, limiting, and fixing the connection between the two. The distance between the bottom of the funnel-shaped reaction cup hopper 1 and the slide of the sorting and loading module 3 should not be less than the height of the reaction cup body, and the bottom of the funnel-shaped reaction cup hopper 1 should be close to the connecting block I 33 of the sorting and loading module 3 to facilitate the automatic adjustment of the attitude of the falling reaction cup. The funnel-shaped reaction cup hopper 1 is provided with a connecting part for fixed connection with the support platform 5. The funnel-shaped reaction cup hopper 1 is provided with a photoelectric detection sensor 17 for monitoring the storage amount of reaction cups in the reaction cup hopper. There can be one or more photoelectric detection sensors 17 and they can be set at different heights.

[0061] Specifically, such as Figure 4As shown, the rotating disturbance mechanism 2 consists of a rotating disturbance rod 21, a drive motor 22, and a motor mounting base 23. The rotating disturbance rod 21 is used to stir the reaction cup in the funnel-shaped reaction cup hopper 1, causing the reaction cup near the bottom frustum hole 14 of the funnel-shaped reaction cup hopper 1 to continuously adjust and change its posture, increasing the probability of the reaction cup falling out of the bottom hole 15. The length of the rotating disturbance rod 21 is determined according to the height of the funnel-shaped reaction cup hopper 1. The upper end of the rotating disturbance rod 21 is fixedly connected to the drive motor shaft, and the rotation axis of the rotating disturbance rod 21 is coaxial with the drive motor shaft. The lower end of the rotating disturbance rod 21 is split into two rods, with a certain angle between the two rods, preferably 50 degrees. The ends of the two rods are bent inwards into a certain arc. The bent portions of the two rod ends are close to the wall surface of the bottom frustum hole 14 of the funnel-shaped reaction cup hopper 1 and maintain a certain gap. The rotating disturbance rod 21 has a certain rigidity and should not deform during the stirring of the reaction cup. The rotating disturbance rod 21 should have a smooth, rounded shape without any sharp edges to avoid scratching the reaction cup during agitation. The material of the rotating disturbance rod 21 is preferably wear-resistant plastic. The drive motor 22 is used to drive the rotating disturbance rod 21 to rotate around its axis, and can control the rotation angle, rotation speed, rotation acceleration, and rotation direction of the rotating disturbance rod 21 whether the funnel-shaped reaction cup hopper 1 is full or empty. A stepper motor is preferred. The motor mounting base 23 is used to fix the drive motor 22 and ensure that the rotating disturbance mechanism 2 is suspended inside the funnel-shaped reaction cup hopper 1. The rotation axis of the rotating disturbance rod 21 is coaxial with the bottom frustum hole 14 and the bottom circular hole 15 of the funnel-shaped reaction cup hopper 1. The motor mounting base 23 is fixedly connected to the support platform 5.

[0062] Specifically, such as Figure 5 As shown, the sorting and loading module 3 consists of a slide plate, connecting blocks, baffles, and photoelectric detection sensors 38. The slide plate and connecting blocks construct the slide. Slide plate I 31 and slide plate II 32 are fixedly connected by connecting blocks I 33 and II 34, forming a slide with a certain interval width. The interval width of the slide should be slightly larger than the diameter of the reaction cup body and smaller than the diameter of the reaction cup flange. The slide depth is greater than the height of the reaction cup body. The slide has a certain inclination angle, preferably 15 degrees with the horizontal direction, to ensure that the reaction cup can slide smoothly under its own weight. A short horizontal section at the end of the slide is provided; the length of this horizontal section should be less than the diameter of the reaction cup. The contact area between the slide and the reaction cup is smooth to reduce frictional resistance. The baffles prevent the reaction cup from detaching from the slide during its descent or descent. Baffles I 35 and II 36 are fixedly connected to the outside of slide plate I 31 and slide plate II 32, and baffle III 37 is fixedly connected to the outside of connecting block I 33. Baffle I 35 and baffle II 36 are equipped with photoelectric detection sensors 38 for monitoring the number of reaction cups in the slide. There may be one or more photoelectric detection sensors 38 and they may be set at different heights.

[0063] Specifically, such as Figure 6As shown, the cup isolation module 4 consists of an electric push rod 41, a lever 42, and a mounting base 43. The electric push rod 41, preferably a self-holding electromagnet, drives the lever 42 to extend or retract a certain distance. The electric push rod 41 moves perpendicular to the slide direction. The lever 42 moves all reaction cups in the slide upwards except for the last one, isolating the last reaction cup from the others. The lever 42 is fixedly connected to the end of the electric push rod 41. The straight section at the front end of the lever 42 forms a certain angle with the direction of movement of the electric push rod 41, preferably 30 degrees. This angle allows the lever 42 to move vertically along the slide while simultaneously pushing the reaction cups upwards along the slide direction. The greater the distance the lever 42 moves vertically along the slide, the greater the distance the reaction cups move upwards along the slide direction. The bottom of the lever 42 slides relative to the mounting base 43, serving as a guide and preventing the lever 42 from flipping. The electric push rod 41 is fixedly connected to the mounting base 43. The mounting base 43 is fixedly connected to the support platform 5 and defines the relative positional relationship between the lever 42, the slide, and the reaction cup.

[0064] Based on the same inventive concept, such as Figure 7 As shown in the figure, this embodiment of the invention also provides a control method for an automatic cup loading device for a chemiluminescence immunoassay analyzer, comprising the following steps:

[0065] S1, the reaction cup stored in the funnel-shaped reaction cup hopper 1 is continuously agitated by the rotating disturbance mechanism 2 to promote its orderly falling.

[0066] S1.1 Open the top cover 11 of the funnel-shaped reaction cup hopper 1, add a certain number of reaction cups through the cup inlet 12, and close the top cover 11.

[0067] S1.2, control the drive motor 22 of the rotary disturbance mechanism 2 to rotate clockwise by a certain angle with a certain acceleration and speed, and then rotate counterclockwise by a certain angle with a certain acceleration and speed, and repeat this cycle. During this process, the reaction cup automatically falls from the bottom round hole 15 of the funnel-shaped reaction cup hopper 1.

[0068] S2 receives the reaction cups through the sorting and loading module 3 and arranges them in sequence within the slide.

[0069] S2.1 When the falling reaction cups come into contact with the slide of the sorting and loading module 3, they automatically adjust their posture and slide down by their own gravity, and the reaction cups are arranged in order in the slide.

[0070] S2.2 When the photoelectric detection sensor 38 of the sorting and loading module 3 detects that the number of reaction cups in the slide reaches a certain amount, the drive motor 22 of the rotating disturbance mechanism 2 is controlled to stop rotating.

[0071] S3, the reaction cup at the end of the slide in the sorting and loading module 3 is isolated from the other reaction cups by the cup isolation module 4, so that the gripper of the chemiluminescence immunoassay analyzer can grab the reaction cup at the end.

[0072] S3.1, the electric push rod 41 of the control cup isolation module 4 extends a certain distance, and the lever 42 moves the other reaction cups in the slide channel, except for the last reaction cup, upward along the slide channel direction, and the jaws of the chemiluminescence immunoassay analyzer pick up the last reaction cup.

[0073] S3.2, the electric push rod 41 of the control cup isolation module 4 retracts a certain distance, and the reaction cup in the slide slides downwards along the slide direction.

[0074] S3.3, Repeat steps S3.1 and S3.2 as needed for the reaction cups used in the chemiluminescence immunoassay analyzer.

[0075] S4 monitors the number of reaction cups in the funnel-shaped reaction cup hopper 1 and the slide through a photoelectric detection sensor, and provides feedback to control the operation of the rotating disturbance mechanism 2 and the cup pushing isolation module 4.

[0076] S4.1 When the photoelectric detection sensor 38 of the sorting and loading module detects that the number of reaction cups in the slide is insufficient, repeat steps S1.2 and S2.2.

[0077] S4.2 When the photoelectric detection sensor 17 of the funnel-shaped reaction cup hopper detects that the number of reaction cups in the funnel-shaped reaction cup hopper 1 is insufficient, step S1.1 is repeated.

[0078] The specific embodiments described above illustrate the technical solution and beneficial effects of the present invention in detail. It should be understood that the above description is only the most preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, additions, and equivalent substitutions made within the scope of the principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A chemical luminescence immunoassay analyzer reaction cup automatic cup handling loading device, characterized by, The device comprises a funnel-shaped reaction cup stock bin, a rotating disturbance mechanism, a sequencing loading module, a cup pushing and isolating module, and a support platform. The funnel-shaped reaction cup stock bin is located at the upper part of the device and is used for storing reaction cups. The funnel-shaped reaction cup stock bin comprises a cup dropping opening, a bottom circular cone hole, a bottom circular hole, and a bottom clamping groove. The bottom circular cone hole is located below the storage bin and its circular cone angle is adapted to the shape of the reaction cup. The bottom circular hole is located below the bottom circular cone hole and comprises an upper section, a middle section, and a lower section. The upper section circular hole is connected to the bottom circular cone hole and is connected through a circular arc surface. The middle section and lower section circular holes are straight holes and their diameters are fixed values and are adapted to the size and shape of the reaction cup.

2. The chemiluminescent immunoassay analyzer reaction cup automatic management cup loading device according to claim 1, characterized in that, The middle section and lower section circular holes are smoothly connected. The bottom clamping groove is used for clamping and fixing the sequencing loading module. The rotating disturbance mechanism is suspended in the funnel-shaped reaction cup stock bin and its rotating axis is coaxial with the bottom circular cone and the bottom circular hole of the funnel-shaped reaction cup stock bin.

3. The CLIA reaction cup auto-loading device according to claim 1, wherein The rotating disturbance mechanism is used for disturbing the reaction cup to make it fall in order.

4. The CLIA reaction cup auto-loading device according to claim 1, wherein The rotating disturbance mechanism comprises a rotating disturbance rod.

5. The CLIA reaction cup auto-loading device according to claim 1, wherein The upper end of the rotating disturbance rod is connected to the shaft of a driving motor. The lower end of the rotating disturbance rod is bifurcated into two rod bodies with an included angle. The ends of the rod bodies are bent inward.

6. The CLIA reaction cup auto-loading device according to claim 1, wherein The sequencing loading module is arranged below the funnel-shaped reaction cup stock bin and is used for receiving the reaction cup falling from the funnel-shaped reaction cup stock bin and arranging the reaction cup in order in a slide.

7. The CLIA reaction cup auto-loading device according to claim 1, wherein The cup pushing and isolating module is arranged at the end of the sequencing loading module and is used for isolating the reaction cup at the end of the slide in the sequencing loading module from the other reaction cups. The support platform is located at the side of the device and is used for fixing and limiting the funnel-shaped reaction cup stock bin, the rotating disturbance mechanism, the sequencing loading module, and the cup pushing and isolating module. The funnel-shaped reaction cup stock bin further comprises a top cover and a storage bin. The top cover comprises a fixed part and an opening and closing part. The fixed part is provided with an opening for avoiding the rotating disturbance mechanism. The opening and closing part is used for closing or opening the cup dropping opening. The storage bin is located below the top cover and the cup dropping opening and is used for storing a certain number of reaction cups. The circular cone angle of the bottom circular cone hole is 40-50 degrees. The diameter of the middle section circular hole of the bottom circular hole is 2-3 times the outer diameter of the cup body of the reaction cup. The sum of the heights of the upper section circular hole and the middle section circular hole should be less than the height of the cup body of the reaction cup. The diameter of the lower section circular hole is 1-1.5 times the diameter of the flange of the reaction cup. The rotating disturbance mechanism further comprises a driving motor and a motor mounting seat. The driving motor is used for driving the rotating disturbance rod to rotate around the axis and controlling the rotation angle, rotation speed, rotation acceleration, and rotation direction of the rotating disturbance rod. The motor mounting seat is fixedly connected with the support platform and is used for fixing the driving motor and ensuring that the rotating disturbance mechanism is suspended in the reaction cup stock bin. The lower end of the rotating disturbance rod is bifurcated into two rod bodies with an included angle of 45-55 degrees. The sequencing loading module comprises a slide plate, a connecting block, and a baffle. The slide plate and the connecting block are used for building a slide. The slide has an included angle of 15-20 degrees with the horizontal direction. The width of the slide is greater than the diameter of the cup body of the reaction cup and is less than the diameter of the flange of the reaction cup. The depth of the slide is greater than the height of the cup body of the reaction cup. The end of the slide has a horizontal section with a length less than the diameter of the reaction cup. The baffle is arranged outside the slide and is used for preventing the reaction cup from falling out.

8. The CLIA reaction cup auto-loading device according to claim 1, wherein, The push cup isolation module comprises an electric push rod, a push lever and a mounting seat; The electric push rod is perpendicular to the slide in the direction of movement, and is used to drive the push lever to extend or retract; The push lever is fixed to the end of the electric push rod, and the front end thereof forms an angle of 25-35 degrees with the direction of movement of the push rod, and is used to push the reaction cup upward when it extends; The mounting seat is fixed to the support platform, and is used to fixedly connect the electric push rod and guide the push lever.

9. The CLIA reaction cup auto-loading device according to claim 1, wherein, The funnel-shaped reaction cup bin is provided with at least one photoelectric detection sensor at different heights of the funnel-shaped reaction cup bin, which is used to monitor the storage amount of the reaction cup; the sorting loading module is also provided with a photoelectric detection sensor on the side thereof, which is used to detect the number of reaction cups in the slide.

10. A method of controlling the reaction cup automatic handling device of a chemiluminescent immunoassay analyzer according to any one of claims 1 to 9, characterized by, The method comprises the following steps: S1, continuously stirring the reaction cup stored in the funnel-shaped reaction cup bin through the rotating disturbance mechanism, so as to promote the orderly falling of the reaction cup; S2, receiving the reaction cup through the sorting loading module and arranging the reaction cup in sequence in the slide; S3, isolating the reaction cup at the end of the slide in the sorting loading module from the remaining reaction cups through the push cup isolation module, so as to facilitate the gripper of the chemiluminescence immunoassay analyzer to grab the reaction cup at the end; S4, monitoring the number of reaction cups in the funnel-shaped reaction cup bin and the slide through the photoelectric detection sensor, and feeding back the control of the operation of the rotating disturbance mechanism and the push cup isolation module.

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