Tibetan medicine nasal drops as well as preparation method and application thereof

Abstract

The invention relates to the technical field of traditional Chinese medicine, in particular to Tibetan medicine nasal drops as well as a preparation method and application thereof, and the Tibetan medicine nasal drops are prepared from the following raw materials in parts by weight: 380-420 parts of liquorice, 280-320 parts of phyllanthus emblica, 8-12 parts of saffron crocus and 8-12 parts of sugar. The Tibetan medicine nasal drops can rapidly permeate into the deep layer of nasal mucosa to play anti-inflammatory, antibacterial and immunoregulation roles, so that the symptoms such as nasal obstruction, running nose and pain caused by nasal inflammation are effectively relieved. In clinical tests, the total effective rate of an experimental group reaches 91.67%, which shows that the traditional Chinese medicine composition has high efficiency in the aspect of treating nasal inflammation.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine technology, specifically to a Tibetan medicine nasal drop, its preparation method, and its application. Background Technology

[0002] Nasal inflammation is a common upper respiratory tract disease, which can be classified into five main types based on etiology: infectious, allergic, occupational, drug-induced, and idiopathic. The systemic harm of nasal inflammation is mainly achieved through three pathways: 1. Activation of the nasopulmonary reflex arc can lead to bronchial smooth muscle contraction, explaining why patients with allergic rhinitis have a 3-5 times higher incidence of asthma than the general population. 2. Chronic nasal congestion causing persistent mouth breathing alters breathing patterns, leading to fragmented sleep structure and reducing deep sleep time by more than 40%, resulting in decreased daytime cognitive function. 3. Systemic dissemination of inflammatory mediators can trigger increased bone marrow hematopoiesis, with peripheral blood eosinophil counts often exceeding 500 / μL.

[0003] Children with nasal inflammation face unique risks. Chronic nasal obstruction can lead to maxillofacial bone developmental abnormalities, manifesting as adenoid facies. Studies show that approximately 65% ​​of untreated children with allergic rhinitis develop at least one craniofacial developmental disorder. Furthermore, conductive hearing loss caused by middle ear ventilation dysfunction can result in delayed language development, the effects of which can persist into adulthood.

[0004] Nasal corticosteroids, such as fluticasone propionate, can effectively suppress inflammatory responses, but long-term use can increase nasal mucosal fragility; clinical studies show that the incidence of nosebleeds can reach 23% in patients using them continuously for more than one year. Antihistamines are effective in controlling early symptoms, but their improvement rate for nasal congestion is less than 40%. Of concern, the cardiotoxicity of second-generation antihistamines remains a significant issue. Immunotherapy shows unique value in the treatment of allergic rhinitis, but a 3-5 year course of treatment reduces patient compliance to approximately 35%. More seriously, for patients with multiple allergens, the effectiveness of existing standardized vaccines has significantly decreased to below 50%. While surgical procedures such as inferior turbinate reduction can immediately improve ventilation, postoperative follow-up data shows a symptom recurrence rate as high as 30% within 5 years. This is mainly because the surgery fails to eliminate the molecular basis of inflammation, only addressing morphological abnormalities. Further complicating matters, excessive resection may lead to empty nose syndrome, causing patients to experience difficult-to-treat complications such as paradoxical nasal congestion. While minimally invasive techniques such as radiofrequency ablation are less traumatic, improper temperature control can lead to permanent damage to the mucociliary transport function. Recent studies have found that patients undergoing radiofrequency ablation experienced a 40% decrease in nasal mucociliary clearance rate compared to pre-treatment levels, directly weakening the respiratory tract's defense function. Biologics such as anti-IgE monoclonal antibodies show promise in the treatment of severe cases, but the annual treatment cost of 100,000 to 150,000 yuan significantly limits their clinical application. Stem cell therapy has been shown to promote mucosal repair in animal experiments, but human studies show that the survival rate of transplanted cells is less than 20%, and there is a risk of abnormal differentiation. Although nasal microecological modulators can temporarily alter the flora composition, the original flora structure returns to its pre-treatment state within two weeks after discontinuation of the medication.

[0005] Therefore, there is an urgent need to provide a new strategy for the treatment of nasal inflammation. Summary of the Invention

[0006] This invention provides a Tibetan medicine nasal drop that effectively treats nasal inflammation, significantly relieving symptoms such as pain, itching, runny nose, and nasal mucosal congestion caused by nasal inflammation.

[0007] This invention provides a Tibetan medicine nasal drop solution, which is made from the following raw materials in parts by weight: Licorice 380-420 parts, Phyllanthus emblica 280-320 parts, saffron 8-12 parts, and sugar 8-12 parts.

[0008] Preferably, the Tibetan medicine nasal drops are made from the following raw materials in parts by weight: 400 parts licorice, 300 parts amla, 10 parts saffron, and 10 parts sugar.

[0009] A second aspect of the present invention provides a method for preparing the Tibetan medicine nasal drops, comprising the following steps: Prepare licorice powder, amla powder, saffron powder and sugar powder; weigh out the licorice powder, amla powder, saffron powder and sugar powder according to the stated weight parts, and set aside for later use; Licorice powder and amla powder were decocted to prepare decoction 1; Saffron powder was decocted to prepare decoction 2; After mixing decoction 1 and decoction 2, add olive oil and powdered sugar, mix well, let stand, sieve, and collect the filtrate to obtain Tibetan medicine nasal drops.

[0010] Preferably, the preparation process of the decoction 1 is as follows: Mix licorice powder and amla powder, add water and decoct 3 times. Combine the 3 decoctions and filter to obtain decoction 1. The decoction temperature is 90℃~100℃ and the decoction time is 60min~120min each time. The amount of water added is 3 to 5 times the weight of licorice powder and amla powder.

[0011] Preferably, the preparation process of the decoction 2 is as follows: Saffron powder is boiled twice with water. The two decoctions are combined and filtered to obtain decoction 2. The boiling temperature is 85℃~95℃ and the boiling time is 30min~35min each time. The amount of water added is 3 to 4 times the weight of saffron powder.

[0012] Preferably, the amount of olive oil added is 1 / 3 to 1 / 2 of the total volume of decoction liquid 1 and decoction liquid 2.

[0013] Preferably, the settling time is 16h to 24h.

[0014] A third aspect of the present invention provides an application of the Tibetan medicine nasal drops, wherein the Tibetan medicine ear drops are used to prepare a drug for treating nasal inflammation.

[0015] Preferably, the nasal inflammation is sinusitis.

[0016] In the raw materials of the Tibetan medicine nasal drops described in this invention, the principal ingredient is licorice, the assistant ingredient is amla, the adjuvant ingredient is saffron, and the guiding ingredient is sugar. Olive oil is used as an excipient. Licorice has the effects of clearing the meridians and relieving heat, and is mainly used to relieve symptoms such as nasal congestion; amla has the effects of clearing heat and detoxifying, and removing blood stasis, and is mainly used to relieve symptoms such as nasal secretions and nasal congestion. Saffron has the effects of clearing heat and reducing fire, and is mainly used to relieve symptoms such as nasal congestion and itching; sugar is mainly used to enhance the sense of smell.

[0017] Compared with the prior art, the beneficial effects of the present invention are as follows: This invention provides a Tibetan medicine nasal drop, which is made from the following raw materials in parts by weight: 380-420 parts licorice, 280-320 parts Phyllanthus emblica, 8-12 parts saffron, and 8-12 parts sugar. This Tibetan medicine nasal drop can rapidly penetrate deep into the nasal mucosa, exerting anti-inflammatory, antibacterial, and immunomodulatory effects, thereby effectively relieving symptoms such as nasal congestion, runny nose, and pain caused by nasal inflammation. In clinical trials, the total effective rate of the experimental group reached 91.67%, significantly higher than the 78.3% of the control group, demonstrating its high efficacy in treating nasal inflammation. Through its unique herbal formula, this Tibetan medicine nasal drop not only relieves symptoms but also promotes the recovery of the nasal mucosa, penetrating deep into the nasal mucosa to effectively clear heat, relieve pain, unblock meridians, improve patient comfort, and help patients fundamentally improve their nasal health and reduce the recurrence of inflammation.

[0018] In addition, the Tibetan medicine nasal drops described in this invention have the following advantages: 1. Improve patient comfort.

[0019] Reduced drug irritation: Compared with traditional nasal medications, the nasal drop formula of this invention is carefully designed to reduce drug irritation, decrease discomfort during use, and improve the patient's medication experience.

[0020] Enhances nasal sense of smell: The sugar component in the formula helps enhance the patient's nasal sense of smell, which is an important improvement for patients whose sense of smell is reduced due to nasal inflammation, and helps improve their quality of life.

[0021] 2. The drug has high stability and safety.

[0022] The herbal ingredients are safe: the raw materials used in this invention are all natural herbs, such as licorice, amla, and saffron. These herbs have a long history of use in traditional medicine, and their safety has been widely recognized.

[0023] Scientific preparation process: A scientific preparation process ensures the stability and consistency of the drug. Strict decoction, filtration, and mixing steps ensure uniform distribution of the drug components, guaranteeing efficacy with each use.

[0024] 3. High cost-effectiveness.

[0025] Low raw material cost: The raw materials of this invention are relatively easy to obtain and have low cost, which makes the nasal drops cost-effective in large-scale production and application.

[0026] Low treatment cost: Compared with some high-cost biological agents or surgical procedures, the Tibetan medicine nasal drops of this invention have a lower treatment cost, which can save patients a lot of medical expenses and make effective treatment affordable for more patients.

[0027] 4. Wide range of applications.

[0028] Various types of nasal inflammation: The Tibetan medicine nasal drops of this invention are suitable for various types of nasal inflammation, including infectious, allergic, and drug-induced inflammations, and have a wide range of applications.

[0029] Patients of different ages: This nasal drop is suitable for patients of different ages, especially children and the elderly, providing a safe and effective treatment option for these special groups.

[0030] 5. It has great clinical application value.

[0031] Filling a market gap: Current treatments for nasal inflammation have certain limitations. The Tibetan medicine nasal drops of this invention provide a new treatment strategy, filling a market gap.

[0032] Improving treatment adherence: Due to its ease of use, significant effects, and low cost, it can improve patient adherence to treatment and help improve long-term patient outcomes.

[0033] In summary, the Tibetan medicine nasal drops of the present invention have significant benefits in the treatment of nasal inflammation. They can not only effectively relieve symptoms and promote mucosal recovery, but also improve patient comfort. They have high stability and safety, are cost-effective, and have a wide range of applications, thus having important clinical application value. Attached Figure Description

[0034] Figure 1 The images show the finished product of Tibetan medicine nasal drops. A: Image of the Tibetan medicine nasal drops; B: A single image of A.

[0035] Figure 2 The patient was treated with Tibetan medicine nasal drops. Detailed Implementation

[0036] The present invention will be further illustrated below with specific embodiments, but these embodiments do not limit the scope of the invention. Modifications or substitutions to the details and form of the technical solutions of the present invention may be made without departing from the spirit and scope of the invention, but all such modifications or substitutions fall within the protection scope of the present invention.

[0037] The inventive concept of this invention is as follows: Tibetan medicine categorizes human physiology and pathology into three major factors: Lung, Tripa, and Pekan. Sinusitis in Tibetan medicine is often classified under "nasal diseases," and its causes are frequently related to imbalances in these three factors due to external pathogenic factors and improper diet and lifestyle. External invasion of cold or heat pathogens causes Lung qi to rise upwards, Tripa heat to become excessive, and Pekan to stagnate in the nasal cavity, leading to symptoms such as nasal congestion, increased secretions, and redness and swelling of the mucous membranes. Treatment should focus on harmonizing these three factors, clearing the nasal passages and detoxifying, and clearing heat and reducing swelling.

[0038] The Tibetan medical classic *Jingzhu Materia Medica* records that licorice is sweet and neutral in nature, possessing the functions of harmonizing various medicines and nourishing and tonifying. Its sweetness can nourish the *Phātu* (a type of medicinal substance), balancing the excess of *Lung* and *Tripa* (another type of medicinal substance), relieving nasal congestion and pain caused by the upward flow of *Lung* qi and excessive *Tripa* heat, and restoring the physiological function of the nasal cavity. Modern research shows that glycyrrhizic acid and glycyrrhizin in licorice have anti-inflammatory and antibacterial effects, inhibiting pathogens such as *Staphylococcus aureus* and reducing inflammation of the sinus mucosa; simultaneously, licorice extract can promote mucosal cell repair and alleviate mucosal damage caused by sinusitis. Licorice can regulate respiratory fluid metabolism, reduce nasal secretion accumulation, and relieve nasal congestion and runny nose symptoms, aligning with the Tibetan medical treatment philosophy of "resolving phlegm and dampness, and clearing the nasal passages."

[0039] In Tibetan medicine, amla (Phyllanthus emblica) is hailed as the "King of Detoxification." It has a sour, astringent, and sweet taste, and is cooling in nature, effectively clearing away heat-related pathogens. Its phenolic and flavonoid compounds can reduce the level of local inflammatory mediators in the sinuses, relieving symptoms such as redness, swelling, heat, and pain. Amla is rich in vitamin C and superoxide dismutase, which can regulate the body's immune function and enhance disease resistance, aligning with the Tibetan medical theory of "strengthening the body's resistance and eliminating pathogens," thus preventing recurrence of sinusitis caused by repeated invasions of external pathogens. Its astringent properties can astringe the nasal mucosa, reduce inflammatory exudate, improve symptoms such as runny nose and nasal congestion, and promote the restoration of the sinuses to their normal physiological state.

[0040] Saffron has a sweet taste and neutral properties, and it enters the heart, liver, and lung meridians. Tibetan medicine believes that it can unblock the flow of qi and blood in the nasal cavity and dispel qi and blood stagnation caused by imbalances in these three factors. Modern research has confirmed that components in saffron, such as crocin and crocin acid, can dilate blood vessels, improve local blood circulation in the sinuses, reduce tissue edema, and relieve nasal congestion. Saffron has significant anti-inflammatory and analgesic effects, can inhibit the release of inflammatory factors, reduce inflammation of the sinus mucosa, and relieve pain symptoms, which aligns with the Tibetan medicine principle of "reducing swelling and relieving pain." Saffron also has detoxifying and nasal-opening functions, clearing heat toxins and blood stasis from the nasal cavity, harmonizing qi and blood, and restoring nasal patency. It is especially suitable for symptoms such as decreased sense of smell and turbinate hypertrophy caused by qi and blood stagnation in the later stages of sinusitis.

[0041] The combination of these three ingredients—licorice root, emblica seed, and saffron—harmonizes the three factors (sinusitis, rhinitis, and phlox), clears heat and strengthens the body, and enhances immunity; and saffron promotes blood circulation, removes blood stasis, clears the nasal passages, and relieves pain. Together, they harmonize the three factors, clear heat and reduce inflammation, and clear the nasal passages and detoxify, treating both the symptoms and the root cause of sinusitis. This combination not only conforms to the holistic conditioning and balancing of the three factors theory of Tibetan medicine, but also aligns with the modern medical treatment approach of anti-inflammatory, antibacterial, and mucosal repair, providing a scientific basis for the Tibetan medicine treatment of sinusitis.

[0042] The sugar in this preparation can absorb moisture from the air, helping to keep the nasal mucosa moist, preventing excessive dryness, and relieving discomfort, pain, and bleeding caused by dryness. It can also improve the local environment: it can alter the local osmotic pressure of the nasal cavity to some extent, allowing nasal mucosal cells to maintain normal morphology and function, which is beneficial for maintaining the physiological state of the nasal cavity.

[0043] Olive oil has excellent lubricating properties, forming a protective film on the nasal mucosa. This reduces direct contact between the nasal mucosa and air, decreasing friction and relieving discomfort caused by inflammation or dryness. It also helps prevent nasal crusting. Furthermore, olive oil contains anti-inflammatory components such as squalene and olive polyphenols, which can reduce inflammation of the nasal mucosa, soothe it, and help alleviate nasal inflammation caused by sinusitis. It can also provide nutrition to the nasal mucosa, promoting the repair and regeneration of mucosal cells and helping damaged nasal mucosa regain normal function.

[0044] To enable those skilled in the art to better understand and implement the technical solutions of this invention, the invention will be further described below with reference to specific embodiments. Unless otherwise specified, all reagents used in this invention are commercially available, and all methods used are conventional techniques in the art.

[0045] In the following examples, 1g represents one part by weight.

[0046] Example 1 A method for preparing Tibetan medicine nasal drops is as follows: S1: Prepare licorice powder, amla powder, saffron powder and sugar powder.

[0047] Licorice, amla, and saffron were separately pulverized using a grinder and passed through a 40-mesh sieve to obtain licorice powder, amla powder, and saffron powder, respectively. Sugar was pulverized and passed through a 200-mesh sieve to obtain powdered sugar.

[0048] S2: Decoction 1 is prepared by decocting licorice powder and amla powder.

[0049] Take 400g of licorice powder and 300g of amla powder, mix them evenly, add 4 times their weight of purified water, and decoct 3 times, controlling the temperature at 90℃ each time. The first decoction is for 60 minutes, the second for 90 minutes, and the third for 120 minutes. Collect the decoction after each decoction, combine the three decoctions and filter to obtain decoction 1.

[0050] S3: Boil saffron powder to prepare decoction 2.

[0051] Take 10g of saffron powder, add water and decoct twice, controlling the temperature at 85℃, for 30 minutes each time. Combine the two decoctions and filter to obtain decoction 2. The weight ratio of water to saffron powder is 1:4.

[0052] S4: After mixing decoction 1 and decoction 2, add olive oil and powdered sugar, mix well, let stand, sieve, and collect the filtrate to obtain Tibetan medicine nasal drops.

[0053] Mix decoction 1 and decoction 2 thoroughly, add 3000mL of olive oil and 10g of powdered sugar, mix well, let stand for 24 hours, then pass the supernatant through a 200-mesh sieve. Divide the filtrate into smaller portions to obtain Tibetan medicine nasal drops. See finished product image. Figure 1 .

[0054] Example 2 A method for preparing Tibetan medicine nasal drops is as follows: S1: Prepare licorice powder, amla powder, saffron powder and sugar powder.

[0055] Licorice, amla, and saffron were separately pulverized using a grinder and passed through a 40-mesh sieve to obtain licorice powder, amla powder, and saffron powder, respectively. Sugar was pulverized and passed through a 200-mesh sieve to obtain powdered sugar.

[0056] S2: Decoction of licorice and amla is prepared by boiling.

[0057] Take 380g of licorice powder and 280g of amla powder, mix them evenly, add three times their weight of purified water, and decoct three times, controlling the temperature at 95℃ each time. The first decoction is for 60 minutes, the second for 80 minutes, and the third for 100 minutes. Collect the decoction after each decoction, combine the three decoctions, and filter to obtain decoction 1.

[0058] S3: Boil saffron powder to prepare decoction 2.

[0059] Take 8g of saffron powder, add water and decoct twice, controlling the temperature at 95℃, for 30 minutes each time. Combine the two decoctions and filter to obtain decoction 2. The weight ratio of water to saffron powder is 1:3.

[0060] S4: After mixing decoction 1 and decoction 2, add olive oil and powdered sugar, mix well, let stand, sieve, and collect the filtrate to obtain Tibetan medicine nasal drops.

[0061] Mix decoction 1 and decoction 2, add 2800mL of olive oil, then add 8g of powdered sugar, mix well, let stand for 18 hours, then pass the supernatant through a 200-mesh sieve, and dispense the filtrate to obtain Tibetan medicine nasal drops.

[0062] Example 3 A method for preparing Tibetan medicine nasal drops is as follows: S1: Prepare licorice powder, amla powder, saffron powder and sugar powder.

[0063] Licorice, amla, and saffron were separately pulverized using a grinder and passed through a 40-mesh sieve to obtain licorice powder, amla powder, and saffron powder, respectively. Sugar was pulverized and passed through a 200-mesh sieve to obtain powdered sugar.

[0064] S2: Decoction 1 is prepared by decocting licorice powder and amla powder.

[0065] Take 420g of licorice powder and 320g of amla powder, mix them evenly, add 5 times their weight of purified water, and decoct 3 times, controlling the temperature at 100℃ each time. The first decoction is for 70 minutes, the second for 90 minutes, and the third for 120 minutes. Collect the decoction after each decoction, combine the three decoctions and filter to obtain decoction 1.

[0066] S3: Boil saffron powder to prepare decoction 2.

[0067] Take 12g of saffron powder, add water and decoct twice, controlling the temperature at 90℃, for 35 minutes each time. Combine the two decoctions and filter to obtain decoction 2. The weight ratio of water to saffron powder is 1:4.

[0068] S4: After mixing decoction 1 and decoction 2, add olive oil and powdered sugar, mix well, let stand, sieve, and collect the filtrate to obtain Tibetan medicine nasal drops.

[0069] Mix decoction 1 and decoction 2, add 3300mL of olive oil and 12g of powdered sugar, mix well, let stand for 16 hours, then pass the supernatant through a 200-mesh sieve, and dispense the filtrate to obtain Tibetan medicine nasal drops.

[0070] Example 4 The application of a Tibetan medicine nasal drop is as follows: This embodiment studies the efficacy of the Tibetan medicine nasal drops prepared in Examples 1 to 3, and their efficacy is similar. For the convenience of subsequent discussion and reference, the results of Example 1 are used here.

[0071] The standards for nasal inflammation testing in this invention are as follows: Diagnostic criteria: The diagnostic criteria were formulated with reference to the "Diagnosis and Treatment of Chronic Sinusitis in China (2018)" and the patient had symptoms such as facial pain or pressure, decreased sense of smell, nasal congestion, and purulent nasal discharge. The patient was diagnosed with chronic sinusitis by nasal endoscopy.

[0072] Diagnostic criteria: Referring to the diagnostic criteria for nasal diseases in the Four Medical Classics, the main symptoms are nasal congestion, purulent nasal discharge, facial pain, and decreased sense of smell, while the secondary symptoms are headache, cough, fever, chills, sore throat or discomfort, etc.

[0073] Inclusion criteria: gender not limited, age 18-60 years; meeting the diagnostic and diagnostic criteria, with stable physical signs under blinding, and signing an informed consent form.

[0074] Exclusion criteria: Patients who have received or are currently receiving treatment for chronic sinusitis, have a history of drug allergies, or have undergone nasal surgery.

[0075] General Information: Patients with sinusitis admitted to the Tibetan Medicine Hospital of Qinghai Province from January 2023 to December 2024 were selected and randomly divided into a control group and an experimental group, with 60 patients in each group. The average age ranged from 20 to 57 years, and the duration of disease ranged from 4 to 10 months.

[0076] Implementation method: The experimental group was given the Tibetan medicine nasal drops prepared in Example 1 of this invention, 3 drops 3 times a day, for 2 courses of treatment, one course of treatment being 7 days. Figure 2 The patient was treated with Tibetan medicine nasal drops.

[0077] The control group received conventional treatment, including Wupeng Pills, 5 pills three times daily, for two courses of treatment, each course lasting seven days. Wupeng Pills were purchased from the Qinghai Provincial Tibetan Medicine Hospital.

[0078] The results are shown in Table 1. Compared with conventional treatment for rhinitis, the Tibetan medicine nasal drops prepared in Example 1 significantly relieved pain, itching, runny nose, and nasal mucosal congestion, and its total effective rate reached 91.67%.

[0079] Table 1. Clinical efficacy of Tibetan medicine nasal drops in treating sinusitis Although preferred embodiments of the invention have been described, those skilled in the art, once they have learned the basic inventive concept, can make other changes and modifications to these embodiments.

[0080] Obviously, those skilled in the art can make various modifications and variations to this invention without departing from its spirit and scope. Therefore, if these modifications and variations fall within the scope of the claims of this invention and their equivalents, this invention also intends to include these modifications and variations.

Claims

1. A Tibetan medicine nasal drop, characterized in that, The Tibetan medicine nasal drops are made from the following raw materials in parts by weight: Licorice 380-420 parts, Phyllanthus emblica 280-320 parts, saffron 8-12 parts, and sugar 8-12 parts.

2. The Tibetan medicine nasal drops as described in claim 1, characterized in that, The Tibetan medicine nasal drops are made from the following raw materials in parts by weight: 400 parts licorice, 300 parts amla, 10 parts saffron, and 10 parts sugar.

3. The method for preparing Tibetan medicine nasal drops as described in claim 1, characterized in that, The following steps are involved: Prepare licorice powder, amla powder, saffron powder and sugar powder; weigh out the licorice powder, amla powder, saffron powder and sugar powder according to the stated weight parts, and set aside for later use; Licorice powder and amla powder were decocted to prepare decoction 1; Saffron powder was decocted to prepare decoction 2; After mixing decoction 1 and decoction 2, add olive oil and powdered sugar, mix well, let stand, sieve, and collect the filtrate to obtain Tibetan medicine nasal drops.

4. The preparation method according to claim 3, characterized in that, The preparation process of the decoction 1 is as follows: Mix licorice powder and amla powder, add water and decoct 3 times. Combine the 3 decoctions and filter to obtain decoction 1. The decoction temperature is 90℃~100℃ and the decoction time is 60min~120min each time. The amount of water added is 3 to 5 times the weight of licorice powder and amla powder.

5. The preparation method according to claim 3, characterized in that, The preparation process of the decoction 2 is as follows: Saffron powder is boiled twice with water. The two decoctions are combined and filtered to obtain decoction 2. The boiling temperature is 85℃~95℃ and the boiling time is 30min~35min each time. The amount of water added is 3 to 4 times the weight of saffron powder.

6. The preparation method according to claim 3, characterized in that, The amount of olive oil added is 1 / 3 to 1 / 2 of the total volume of decoction liquid 1 and decoction liquid 2.

7. The preparation method according to claim 3, characterized in that, The settling time is 16h~24h.

8. The application of the Tibetan medicine nasal drops as described in claim 1, characterized in that, The Tibetan medicine ear drops are used to prepare medicine for treating nasal inflammation.

9. The application as described in claim 8, characterized in that, The nasal inflammation is sinusitis.

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