Brain nerve repairing and regenerating composition as well as preparation method and application thereof

Abstract

The invention belongs to the field of biological medicine, and provides a brain nerve repairing and regenerating composition as well as a preparation method and application thereof. The composition consists of 28 amino acids, mannitol low-molecular peptide and endogenous coenzyme B12, and all the components have a synergistic effect: the amino acids supply energy, regulate the environment in the brain, resist oxidation and regulate emotion; mannitol low-molecular peptide has nerve protection, growth promotion, oxidation resistance and inflammation resistance; the endogenous coenzyme B12 promotes nerve regeneration, promotes myeloid phospholipid formation, prevents encephalatrophy and improves mental symptoms. The preparation method comprises the following steps: accurately weighing the raw materials, uniformly mixing at proper temperature and humidity, sterilizing and packaging. The composition can remove neuroendotoxin, promote synthesis of nucleic acid and protein into nerve cells, further improve brain functions, repair cranial nerves and activate brain cells, and is suitable for treatment of multiple nervous system diseases such as insomnia, neuralgia, neuromuscular diseases, epilepsy, migraine and mental and psychological disorders.

Description

Technical Field

[0001] This invention relates to the field of biomedical technology, specifically to a brain nerve repair and regeneration composition, its preparation method, and its application in the preparation of drugs for treating nervous system diseases. Background Technology

[0002] With the accelerated pace of modern life, increased work pressure, and the rapid aging of the population, the incidence of neurological diseases is showing a year-on-year upward trend. Neurological disorders such as insomnia, neuralgia, neurodegenerative diseases, and mental health issues not only severely impact patients' quality of life but also impose a heavy burden on families and society.

[0003] Currently, there are various treatments for neurological diseases, but most have certain limitations. For example, traditional drug treatments often only alleviate single symptoms and are difficult to fundamentally repair damaged nerve cells and improve brain function; physical therapy and surgery may be accompanied by high risks and complications, and their applicability is limited. Therefore, developing a safe and effective treatment method that can comprehensively improve brain function has become an important problem that urgently needs to be solved in the current biomedical field. Summary of the Invention

[0004] This invention aims to provide a brain nerve repair and regeneration composition, which is a carefully crafted combination of 28 amino acids, mannitol low-molecular-weight peptides, and endogenous coenzyme B12. The components work synergistically to provide crucial support for the repair and regeneration of the nervous system, improving brain nerve function on multiple levels and treating various neurological diseases.

[0005] To achieve the above objectives, the present invention provides the following technical solution:

[0006] The brain nerve repair and regeneration composition is a sophisticated combination of 28 amino acids, mannitol low molecular weight peptides, and endogenous coenzyme B12. The components work synergistically to repair and regenerate the nervous system.

[0007] A method for preparing a brain nerve repair and regeneration composition includes the following steps:

[0008] Raw material preparation: Accurately weigh 28 kinds of amino acids, mannitol low molecular weight peptides and endogenous coenzyme B12 raw materials;

[0009] Mixing: Place the weighed raw materials into the mixing equipment and mix them thoroughly and evenly at a suitable temperature and stirring speed to ensure that all components are evenly dispersed;

[0010] Sterilization: The mixed composition is sterilized by methods such as high-temperature instantaneous sterilization or filtration sterilization to ensure the sterility and stability of the product;

[0011] Packaging: The sterilized composition is dispensed and packaged to obtain the finished product.

[0012] Application of a brain nerve repair and regeneration composition in the preparation of drugs for treating nervous system diseases.

[0013] Furthermore, the neurological disorders include insomnia, excessive dreaming, amnesia, trigeminal neuralgia, facial neuritis, hemifacial spasm, occipital neuralgia, sciatica, diabetic peripheral neuropathy, myasthenia gravis, progressive muscular dystrophy, periodic paralysis, polymyositis, epilepsy, and migraine.

[0014] Furthermore, the aforementioned neurological disorders also include mental stress, poor mental state, weakness, fatigue, abnormal skin sensations and pain, decreased self-control, irritability, anxiety, depression, shortness of breath, sudden excitement, insomnia, hallucinations, headache, dizziness, palpitations, arrhythmia, neck discomfort, nausea, vomiting, abdominal distension, diarrhea, constipation, frequent urination, sexual dysfunction, menstrual disorders, and decreased memory, attention, and reaction time.

[0015] Furthermore, the brain nerve repair and regeneration composition achieves therapeutic effects through the following mechanism of action:

[0016] Step 1: Clear neuroendotoxins and promote brain metabolism;

[0017] Step 2: Promote the synthesis of nucleic acids and proteins to enter nerve cells;

[0018] Step 3: Improve brain function, repair brain nerves, and activate brain cells.

[0019] The brain nerve repair and regeneration composition of the present invention has the following beneficial effects:

[0020] Synergistic effect of multiple components: 28 kinds of amino acids, mannitol low molecular weight peptides and endogenous coenzyme B12 are scientifically combined. The components work together to play a role in multiple aspects such as energy supply, anti-oxidation, anti-inflammation, promoting nerve growth and repair, so as to comprehensively improve brain nerve function.

[0021] Comprehensive therapeutic effect: Compared with traditional drugs, this composition can simultaneously treat the symptoms and causes of multiple neurological diseases, with a wider range of treatment and better therapeutic effect.

[0022] High safety: This composition uses natural bioactive ingredients, has few side effects, is highly safe, and is suitable for long-term use, providing patients with a safer and more reliable treatment option. Detailed Implementation

[0023] The present invention will now be described in more detail and in a more complete manner.

[0024] This invention provides a brain nerve repair and regeneration composition, which is a carefully crafted combination of 28 amino acids, mannitol low-molecular-weight peptides, and endogenous coenzyme B12. The components work synergistically to provide crucial support for the repair and regeneration of the nervous system, improving brain nerve function on multiple levels and treating various neurological diseases.

[0025] I. Composition and Functions of the Composition

[0026] 28 amino acids:

[0027] As an energy source for cells, glucose can be converted into glucose in the brain through gluconeogenesis, providing a continuous and stable energy supply to the brain and maintaining its normal physiological activities.

[0028] It helps maintain the stability of the brain's internal environment, regulates acid-base balance and osmotic pressure, and ensures that brain cells are in a suitable living environment;

[0029] Some amino acids have antioxidant properties, which can eliminate free radicals in the brain, protect brain cells from oxidative stress damage, and delay brain cell aging and death;

[0030] Specific amino acid supplements can help improve memory, learning ability, and cognitive function, and promote brain development and functional enhancement.

[0031] Tryptophan plays an important role in mood regulation. For example, it is a precursor to serotonin, which is closely related to mood stability and sleep regulation. Tryptophan deficiency may lead to depressive symptoms.

[0032] Mannitol low molecular weight peptides:

[0033] It has neuroprotective and nerve growth promoting effects, and can form a protective barrier around nerve cells to reduce damage to nerve cells from external factors;

[0034] It possesses antioxidant and anti-inflammatory functions, which can effectively inhibit oxidative stress response and the release of inflammatory factors, protect brain cells from oxidative stress and inflammatory damage, and thus play a neuroprotective role.

[0035] It helps promote the growth and repair of nerve cells, providing essential nutrients and growth signals for nerve cell regeneration, and has a positive promoting effect on the recovery after nerve injury. Among them, glutathione (GSH), as a low molecular weight peptide containing three amino acids, has a strong antioxidant effect and can further enhance the antioxidant capacity of the composition.

[0036] Endogenous Coenzyme B12 combination:

[0037] It plays a variety of important roles in the brain and nerves, promoting the regeneration of nerve cells and repairing damaged nerve cells, thus accelerating the recovery of nerve function.

[0038] It helps form myelin, a protective sheath that wraps around nerve fibers. Myelin allows nerves to send electrical impulses to other nerves quickly and efficiently, which is crucial for the accurate transmission of nerve signals.

[0039] To prevent brain volume reduction in the elderly, reduce the risk of brain atrophy, and maintain the normal structure and function of the brain;

[0040] Maintaining healthy nerve cells can help prevent Alzheimer's disease and may also be helpful in treating depression, stress, and other anxiety disorders.

[0041] II. Composition Formulation

[0042] This brain nerve repair and regeneration composition is made of 28 kinds of amino acids, mannitol low molecular weight peptides and endogenous coenzyme B12 mixed in a specific ratio. The specific ratio can be adjusted appropriately according to different application needs and patient conditions.

[0043] III. Preparation Method

[0044] Raw material preparation: Accurately weigh 28 kinds of amino acids, mannitol low molecular weight peptides and endogenous coenzyme B12 raw materials to ensure that the quality and purity of the raw materials meet the requirements;

[0045] Mixing: Place the weighed raw materials into a mixing device and mix thoroughly and evenly at a suitable temperature (20-30℃) and stirring speed (100-300 rpm) to ensure that the components are evenly dispersed and form a stable composition;

[0046] Sterilization: The mixed composition is sterilized by high-temperature instantaneous sterilization (temperature 121-134℃, time 2-5 seconds) or filtration sterilization (filtration using a 0.22μm microporous membrane) to ensure the sterility and stability of the product.

[0047] Packaging: The sterilized composition is dispensed and packaged, and the appropriate packaging form is selected according to different usage methods, such as capsules, tablets, or oral liquids, to obtain the finished product.

[0048] IV. Implementation Methods

[0049] (1) Clear neuroendotoxins and promote brain metabolism

[0050] After the patient takes this brain nerve repair and regeneration composition as prescribed, the ingredients in the composition take effect rapidly. Amino acids and other components can regulate the brain's metabolic environment, promote the excretion of neuroendotoxins, improve cerebral microcirculation, and create favorable conditions for the repair and regeneration of nerve cells. Simultaneously, the composition's antioxidant and anti-inflammatory effects can reduce inflammatory responses in the brain, further promoting normal brain metabolism.

[0051] (2) Promotes the synthesis of nucleic acids and proteins and their entry into nerve cells

[0052] The amino acids in the composition serve as raw materials for the synthesis of nucleic acids and proteins, entering nerve cells through specific transport mechanisms. Endogenous coenzyme B12 and other components activate intracellular signaling pathways, promoting the synthesis of nucleic acids and proteins and providing the necessary material basis for nerve cell growth, division, and repair. Mannitol low-molecular-weight peptides provide nutritional support to nerve cells, enhance cellular metabolic activity, and promote the smooth progress of the synthesis process.

[0053] (3) Improve brain function, repair brain nerves, and activate brain cells

[0054] As nucleic acid and protein synthesis increases, the structure and function of nerve cells gradually return to normal. Damaged nerves are repaired, dormant brain cells are activated, and nerve signal transmission becomes smoother. The patient's brain function is significantly improved, symptoms such as insomnia, neuralgia, and mental and psychological disorders gradually lessen or disappear, and cognitive functions such as memory, attention, and reaction time are enhanced.

[0055] V. Indications

[0056] This brain nerve repair and regeneration composition is suitable for the treatment and improvement of the following neurological diseases:

[0057] Neuropathic pain disorders: trigeminal neuralgia, facial neuritis, hemifacial spasm, occipital neuralgia, sciatica, diabetic peripheral neuropathy;

[0058] Neuromuscular diseases: myasthenia gravis, progressive muscular dystrophy, periodic paralysis, polymyositis;

[0059] Paroxysmal neurological disorders: epilepsy, migraine;

[0060] Mental and psychological disorders: mental tension, poor mental state, weakness, fatigue, decreased self-control, irritability, anxiety, depression, irritability, sudden excitement, insomnia, and hallucinations;

[0061] Other neurological symptoms include headache, dizziness, palpitations, arrhythmia, neck discomfort, nausea, vomiting, abdominal distension, diarrhea, constipation, frequent urination, sexual dysfunction, menstrual disorders, memory loss, decreased attention and reaction time, abnormal skin sensations, and pain.

[0062] The above description is merely a specific embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any variations or substitutions that can be easily conceived by those skilled in the art within the technical scope disclosed in the present invention should be included within the scope of protection of the present invention. Therefore, the scope of protection of the present invention should be determined by the scope of the claims.

Claims

1. A brain nerve repair and regeneration composition, characterized in that: It is composed of 28 kinds of amino acids, mannitol low molecular weight peptides and endogenous coenzyme B12. The components work synergistically to repair and regenerate the nervous system.

2. A method for preparing the brain nerve repair and regeneration composition as described in claim 1, characterized in that, Includes the following steps: Raw material preparation: Accurately weigh 28 kinds of amino acids, mannitol low molecular weight peptides and endogenous coenzyme B12 raw materials; Mixing: Place the weighed raw materials into the mixing equipment and mix them thoroughly and evenly at a suitable temperature and stirring speed to ensure that all components are evenly dispersed; Sterilization: The mixed composition is sterilized by methods such as high-temperature instantaneous sterilization or filtration sterilization to ensure the sterility and stability of the product; Packaging: The sterilized composition is dispensed and packaged to obtain the finished product.

3. The use of the brain nerve repair and regeneration composition as described in any one of claims 1-2 in the preparation of a medicament for treating nervous system diseases.

4. The application according to claim 3, characterized in that: The neurological disorders mentioned include insomnia, excessive dreaming, forgetfulness, trigeminal neuralgia, facial neuritis, hemifacial spasm, occipital neuralgia, sciatica, diabetic peripheral neuropathy, myasthenia gravis, progressive muscular dystrophy, periodic paralysis, polymyositis, epilepsy, and migraine.

5. The application according to claim 6, characterized in that: The neurological disorders also include mental stress, poor mental state, weakness, fatigue, abnormal skin sensations and pain, decreased self-control, irritability, anxiety, depression, shortness of breath, sudden excitement, insomnia, hallucinations, headache, dizziness, palpitations, arrhythmia, neck discomfort, nausea, vomiting, abdominal distension, diarrhea, constipation, frequent urination, sexual dysfunction, menstrual disorders, and decreased memory, attention, and reaction time.

6. The application according to any one of claims 3-5, characterized in that: The brain nerve repair and regeneration composition achieves its therapeutic effect through the following mechanism of action: Step 1: Clear neuroendotoxins and promote brain metabolism; Step 2: Promote the synthesis of nucleic acids and proteins to enter nerve cells; Step 3: Improve brain function, repair brain nerves, and activate brain cells.