Microscopic end-side anastomosis stent

Abstract

The invention discloses a microscopic end-side anastomosis stent which comprises a circular tube part, a taper tube part and an annular surface part which are sequentially connected in the axial direction, at least the taper tube part is of a net-shaped hollow structure, and the caliber of the taper tube part is gradually increased from the circular tube part to the annular surface part. The microscopic end-side anastomosis stent is easy to operate, the microoperation difficulty can be reduced, the learning period can be shortened, the anastomosis success rate is increased, and the risk of postoperative obstruction is reduced; due to the net-shaped hollow structure, the visual field in an operation is greatly improved, suture of a needle and fixation of the stent are facilitated, the difficulty of the operation is greatly reduced, and the stent has certain elasticity, so that the stent is better adapted to creeping, expansion and contraction of tissues at the anastomosis position; specific drugs can be attached to the surface of the stent, and multi-scene operation requirements can be met; a stent assisting scheme for assisting the anastomosis of the tubule and the large tissue surface end side is provided, and the technical blank in the field is filled.

Description

Technical Field

[0001] This invention relates to the field of surgical instruments, and more particularly to a microscopic end-to-side anastomosis stent. Background Technology

[0002] Anastomotic stents are medical devices used to support the anastomosis after surgery. Their main advantages include reducing the risk of anastomotic leakage and maintaining structural stability.

[0003] The applicant found that previous studies lacked scaffolds to assist in microscopic tubule anastomosis to larger tissue surfaces, namely, so-called end-to-side (tubule-to-face) anastomosis scaffolds. Currently, microsurgical anastomosis procedures such as vascular anastomosis, lymphatic-venous anastomosis, and vas deferens-epididymis anastomosis still mainly rely on the surgeon's clinical experience, but the long training period for surgeons is difficult to overcome. On the other hand, surgical procedures involving tubule anastomosis to larger tissue surfaces are time-consuming, difficult, and complex, and the success rate of anastomosis is hard to guarantee. Even with experienced surgeons, there is a risk of anastomotic stenosis or secondary obstruction postoperatively. Summary of the Invention

[0004] The purpose of this invention is to provide a microscopic end-to-side anastomosis stent to assist in the anastomosis of small channels with large tissue surfaces, thereby reducing surgical time, simplifying the surgical procedure, reducing surgical difficulty, and improving the success rate of anastomosis.

[0005] The objective of this invention is achieved by the following technical solution: a microscopic end-to-side anastomosis stent, comprising a circular tube portion, a conical tube portion, and an annular portion connected sequentially along the axial direction, wherein at least the conical tube portion has a mesh-like perforated structure, and the diameter of the conical tube portion gradually increases from the circular tube portion to the annular portion.

[0006] In an alternative embodiment, the circular tube portion and / or the annular portion has a mesh-like perforated structure.

[0007] In an alternative embodiment, the tapered tube includes a first suture area and a second suture area, wherein the mesh perforation density of the first suture area is greater than that of the second suture area.

[0008] In an alternative embodiment, the annular portion is bent or tilted toward the circular tube portion.

[0009] In an alternative embodiment, in the microsurgical end-side anastomosis stent, at least the surface of the conical portion is configured to hold one or more drugs.

[0010] In an alternative embodiment, the outer surface of the tapered tube has a microporous structure.

[0011] In an alternative embodiment, the microscopic end-to-end anastomosis stent is formed by 3D printing or weaving.

[0012] In an alternative embodiment, the microsurgical end-to-end anastomosis scaffold is a non-degradable elastic scaffold, the material of which includes, but is not limited to, nickel-titanium alloy, cobalt-chromium alloy or nylon.

[0013] In one alternative embodiment, the microsurgical end-to-end anastomosis scaffold is a biodegradable elastic scaffold, the materials of which include, but are not limited to, sodium alginate, chitosan, collagen, poly(L-lactide)-PLLA, poly(lactic-co-glycolic acid)-PLGA, or polydioxanone-PDO.

[0014] In one alternative embodiment, the length of the circular tube portion is 1.5 mm to 2 mm; and / or, The diameter of one end of the tapered tube is 0.5mm-1mm, and the diameter of the other end is 2mm-3mm; and / or, The outer diameter of the annular portion is 3mm-5mm; and / or, The total length of the microscopic end-to-side anastomosis stent is 3mm-5mm.

[0015] In an alternative embodiment, the microscopic end-to-side anastomosis support is used to connect the tube end of the first target to the side anastomosis port of the second target; wherein the tube end diameter of the first target is smaller than the side anastomosis port diameter of the second target, and the two are anastomosed on the conical tube portion.

[0016] In one alternative embodiment, both the first target and the second target are blood vessels; or, the first target is a lymphatic vessel and the second target is a vein; or, the first target is a vas deferens and the second target is an epididymis.

[0017] Compared with the prior art, the beneficial effects of the present invention include at least the following: 1. The operation is simple, which can reduce the difficulty of microsurgery and the learning cycle, improve the success rate of anastomosis, and reduce the risk of postoperative obstruction.

[0018] 2. The mesh-like perforated structure greatly improves the intraoperative field of vision, which is conducive to needle suturing and stent fixation, greatly reduces the difficulty of the operation, and makes the stent have a certain degree of elasticity, so as to better adapt to the peristalsis and expansion and contraction of the anastomosis tissue.

[0019] 3. The conical tube achieves an organic combination of "rigid fixation" and "flexible transition" on both sides, effectively solving the problem of ensuring firm fixation while avoiding excessive tissue damage in microsurgical end-to-side anastomosis surgery.

[0020] 4. Specific drugs can be attached to the surface of the stent to meet the needs of surgery in multiple scenarios.

[0021] 5. It provides a stent-assisted solution to help small tubes anastomose with the ends of large tissue surfaces, filling a technological gap in this field. Attached Figure Description

[0022] Figure 1 This is a three-dimensional structural schematic diagram of the microscopic end-side anastomosis stent of the present invention.

[0023] Figure 2 This is a schematic diagram of the planar structure of the microscopic end-side anastomosis stent of the present invention.

[0024] Figure 3 This is a schematic diagram before the first and second objectives coincide.

[0025] Figure 4 This is a schematic diagram showing the first and second targets after being anastomosed using a microscopic end-to-side anastomosis stent.

[0026] In the diagram: 1. Circular tube section; 2. Conical tube section; 21. First suture area; 22. Second suture area; 3. Circular section; 4. First target; 5. Second target. Detailed Implementation

[0027] Exemplary embodiments will now be described more fully with reference to the accompanying drawings. However, these exemplary embodiments can be implemented in many forms and should not be construed as limited to the embodiments set forth herein; rather, they are provided to make the invention more comprehensive and complete, and to fully convey the concept of the exemplary embodiments to those skilled in the art. The same reference numerals in the drawings denote the same or similar structures, and therefore repeated descriptions of them will be omitted.

[0028] The terms used to express position and direction in this invention are illustrated with reference to the accompanying drawings, but changes can be made as needed, and all such changes are included within the scope of protection of this invention.

[0029] See Figures 1 to 4 As shown, this invention discloses a microscopic end-to-side anastomosis stent, which assists in the anastomosis of small tubes to large tissue surfaces. More specifically, the microscopic end-to-side anastomosis stent is used to connect the tube end of a first target 4 to the side anastomosis port of a second target 5, wherein the tube end diameter of the first target 4 is smaller than the side anastomosis port diameter of the second target 5.

[0030] like Figure 1 As shown, the overall length of the microscopic end-side anastomosis stent of the present invention is approximately 3mm-5mm, and includes a circular tube portion 1, a tapered tube portion 2, and an annular portion 3 connected sequentially along the axial direction.

[0031] The diameter of the round tube 1 is approximately 0.5 mm to 1 mm and the length is 1.5 mm to 2 mm. In this application, the round tube 1 is used to connect the end of the small tube (i.e., the first target 4) that needs to be sewn together.

[0032] The conical tube portion 2 has a diameter of 0.5 mm-1 mm at one end and 2 mm-3 mm at the other end. In this stent, at least the conical tube portion 2 has a mesh-like perforated structure, and the diameter of the conical tube portion 2 gradually increases from the circular tube portion 1 towards the annular portion 3. In this application, the conical tube portion 2 is used to expand the end of the small tube, thereby facilitating subsequent anastomosis. Furthermore, the mesh-like perforated design greatly improves the intraoperative field of vision, facilitating needle suturing and stent fixation, and significantly reducing the difficulty of the surgery. In addition, the mesh-like perforated structure saves material while allowing the stent to have a certain degree of elasticity, thus better adapting to the peristalsis and expansion / contraction of the tissue at the anastomosis site, reducing anastomotic tension caused by rigidity.

[0033] The annular portion 3 extends radially outward from the large opening of the conical tube portion 2, and its outer diameter is approximately 3mm-5mm. In this application, the annular portion 3 is used to hook the lateral anastomosis of the large tissue surface (i.e., the second target 5) that needs to be sutured, so as to reduce or avoid retraction that would cause anastomotic tension at the connection between the lateral anastomosis and the tube end.

[0034] Combination Figure 3 and Figure 4 As shown, the process of anastomosis between the small tube and the large tissue surface is as follows: S1. The circular tube portion 1 and the annular portion 3 of the stent are respectively implanted into the small tube and the large tissue surface; S2. The tube end of the small tube is expanded by means of the conical tube section 2, and the lateral anastomosis of the large tissue surface is attached to the conical tube section 2. S3. Adjust the position of the anastomosis between the tube end and the side, and use sutures to connect the two to the mesh-like perforated structure of the tapered tube section 2.

[0035] Compared to existing end-to-side anastomosis surgeries, the microscopic end-to-side anastomosis stent of this application solves the problems of difficult tube expansion and inaccurate control of anastomotic surface tension by transferring the anastomosis position to the conical tube 2. The suturing operation is not limited by angle, which effectively simplifies the surgical procedure, reduces the difficulty of the operation, and improves the success rate of anastomosis.

[0036] Furthermore, in some embodiments, the circular tube portion 1 and / or the annular portion 3 have a mesh-like perforated structure, thereby further enhancing the overall elasticity of the stent and adapting precisely to the natural movements of the tissue at the anastomosis site, such as peristalsis and expansion / contraction, ensuring implantation effectiveness. On the other hand, the small tubes and / or large tissue surfaces can also be partially embedded into the circular tube portion 1 and / or the annular portion 3, thereby enhancing the bonding strength with the stent and reducing the risk of stent loosening.

[0037] See Figure 4 As shown, in some embodiments, the tapered tube portion 2 includes a first stitching area 21 and a second stitching area 22, wherein the mesh perforation density of the first stitching area 21 is greater than that of the second stitching area 22.

[0038] It is understandable that the high-density first suture zone 21 allows for a more even distribution of pressure at the end of the expanded tube, ensuring initial fixation strength and preventing slippage. The low-density second suture zone 22 primarily serves as a transitional connection, reducing mechanical stimulation to the tissue and maintaining appropriate flexibility at the lateral anastomosis. Furthermore, the boundary between the first and second suture zones 21 provides clear positioning markers for suturing, guiding the surgeon's standardized procedures. Through differentiated density zoning design, the conical tube section 2 achieves an organic combination of "rigid fixation" and "flexible transition" on both sides, effectively solving the problem of ensuring firm fixation while avoiding excessive tissue damage in microsurgical end-to-side anastomosis surgery.

[0039] See Figure 2 As shown, in some embodiments, the annular face 3 is bent or tilted toward the circular tube 1 to better hook the anastomotic surface, reduce the risk of tissue tearing during suturing, and improve the anastomosis effect.

[0040] In some embodiments, the surface of at least the conical tube portion 2 of the microscopic end-to-side anastomosis stent is configured to carry one or more drugs. It should be understood that the mesh-like perforated structure of the conical tube portion 2 provides a high specific surface area, which is beneficial for drug loading and sustained release. Drugs can be adhered to the surface of the conical tube portion 2 through material adsorption or coating technology, and by configuring different drugs or drug combinations, it can meet the needs of various scenarios, such as anticoagulation, anti-bioadhesion, anti-inflammatory, and sperm motility promotion.

[0041] Furthermore, the outer surface of the conical tube 2 has a microporous structure to further increase its drug-carrying area and drug capacity. After the drug is consumed, the microporous structure can fit into the inner cavity of the small tube and the large tissue surface, thereby strengthening the binding firmness.

[0042] In some embodiments, the microscopic end-to-end anastomosis stent is formed by 3D printing or weaving. This application preferably uses 3D printing, which enables manufacturing with a precision of 50 μm and allows control over the location and concentration of drug distribution, ensuring precise control over stent size and drug delivery.

[0043] In some embodiments, the microsurgical end-to-side anastomosis scaffold is a non-degradable elastic scaffold, made of materials including but not limited to nickel-titanium alloy, cobalt-chromium alloy, or nylon. This type of scaffold is implanted long-term or permanently in the body, continuously supporting the short tube of the tubule and maintaining the patency of the lateral anastomosis of the large tissue surface. Alternatively, the microsurgical end-to-side anastomosis scaffold can be a biodegradable elastic scaffold, made of materials including but not limited to natural biodegradable biomaterials such as sodium alginate, chitosan, and collagen, or synthetic biodegradable biomaterials such as poly(L-lactide)-PLLA, poly(lactic-co-glycolic acid)-PLGA, or polydioxanone-PDO. This type of scaffold can be degraded over a period of time after implantation.

[0044] Example 1 Both the first target 4 and the second target 5 are blood vessels, such as the spermatic vein and the inferior epigastric vein, and the diameter of the port of the first target 4 is smaller than the diameter of the lateral anastomosis of the second target 5.

[0045] The corresponding microsurgical end-to-side anastomotic stent can be made of nickel-titanium alloy (non-degradable, elastic support), and the drug on its surface can be heparin (anticoagulant) combined with rapamycin (anti-proliferative). The total length of the stent is 4.2 mm, of which the circular tube 1 is 1.8 mm long and has a diameter of 0.8 mm (matching the radial artery); the small port diameter of the conical tube 2 is 0.8 mm and the large port diameter is 2.5 mm; and the outer diameter of the circumferential section 3 is 4 mm.

[0046] Example 2 The first target 4 is a lymphatic vessel, and the second target 5 is a vein. The diameter of the port of the first target 4 is smaller than the diameter of the lateral anastomosis of the second target 5.

[0047] The corresponding microsurgical end-to-side anastomosis stent can be made of poly(lactic-co-glycolic acid)-PLGA (biodegradable, with a 6-month absorption cycle), and the drug on its surface can be heparin (anticoagulant) combined with dexamethasone (anti-inflammatory). The total length of the stent is 3.5 mm, of which the circular tube 1 is 1.5 mm long and has a diameter of 0.5 mm (to match lymphatic vessels); the conical tube 2 has a small port diameter of 0.5 mm and a large port diameter of 2 mm; and the outer diameter of the circumferential face 3 is 3 mm (to avoid venous collapse).

[0048] Example 3 The first target 4 is the vas deferens, and the second target 5 is the epididymis. The diameter of the tube port of the first target 4 is smaller than the diameter of the lateral anastomosis port of the second target 5.

[0049] The corresponding microscopic end-to-side anastomosis scaffold can be made of chitosan (biodegradable, with a 3-month absorption cycle), and the drug on its surface can be prostaglandin E (promoting sperm motility) combined with ciprofloxacin (antibacterial). The total length of the scaffold is 5 mm, of which the circular tube 1 is 2 mm long and has a diameter of 1 mm (matching the vas deferens); the conical tube 2 has a small port diameter of 1 mm and a large port diameter of 3 mm; and the annular facet 3 has an outer diameter of 5 mm (covering the epididymal section).

[0050] Although embodiments of the present invention have been shown and described above, it is understood that the above embodiments are exemplary and should not be construed as limiting the present invention. Those skilled in the art can make changes, modifications, substitutions and variations to the above embodiments within the scope of the invention without departing from the principles and spirit of the invention, and all such changes should fall within the protection scope of the claims of the present invention.

Claims

1. A microscopic end-to-side anastomosis stent, characterized in that, It includes a circular tube section (1), a tapered tube section (2) and an annular section (3) connected sequentially along the axial direction, wherein at least the tapered tube section (2) has a mesh-like hollow structure, and the diameter of the tapered tube section (2) gradually increases from the circular tube section (1) to the annular section (3).

2. The microscopic end-to-side anastomosis stent according to claim 1, characterized in that, The circular tube portion (1) and / or the annular portion portion (3) have a mesh-like hollow structure.

3. The microscopic end-to-side anastomosis stent according to claim 1, characterized in that, The conical tube section (2) includes a first suture area (21) and a second suture area (22), wherein the mesh perforation density of the first suture area (21) is greater than that of the second suture area (22).

4. The microscopic end-to-side anastomosis stent according to claim 1, characterized in that, The annular portion (3) is bent or tilted toward the circular tube portion (1).

5. The microscopic end-to-side anastomosis stent according to claim 1, characterized in that, In the microsurgical end-side anastomosis stent, at least the surface of the conical tube portion (2) is configured to carry one or more drugs.

6. The microscopic end-to-side anastomosis stent according to claim 5, characterized in that, The outer surface of the tapered tube (2) has a microporous structure.

7. The microsurgical end-to-side anastomosis stent according to any one of claims 1-6, characterized in that, The microscopic end-to-side anastomosis stent is formed by 3D printing or weaving.

8. The microscopic end-to-side anastomosis stent according to claim 7, characterized in that, The microsurgical end-to-side anastomosis scaffold is a non-degradable elastic scaffold, and its materials include, but are not limited to, nickel-titanium alloy, cobalt-chromium alloy, or nylon.

9. The microscopic end-to-side anastomosis stent according to claim 7, characterized in that, The microsurgical end-to-side anastomosis scaffold is a biodegradable elastic scaffold, and its materials include, but are not limited to, sodium alginate, chitosan, collagen, poly(L-lactide)-PLLA, poly(lactic-co-glycolic acid)-PLGA, or polydioxanone-PDO.

10. The microscopic end-to-side anastomosis stent according to claim 8 or 9, characterized in that, The length of the circular tube portion (1) is 1.5mm-2mm; and / or, The conical tube section (2) has a diameter of 0.5 mm - 1 mm at one end and 2 mm - 3 mm at the other end; and / or, The outer diameter of the annular portion (3) is 3mm-5mm; and / or, The total length of the microscopic end-to-side anastomosis stent is 3mm-5mm.

11. The microsurgical end-to-side anastomosis stent according to any one of claims 1-6, characterized in that, The microscopic end-to-side anastomosis stent is used to connect the tube end of the first target (4) to the side anastomosis port of the second target (5); Wherein, the pipe port diameter of the first target (4) is smaller than the side anastomosis port diameter of the second target (5), and the two are anastomosed on the tapered tube (2).

12. The microscopic end-to-side anastomosis stent according to claim 11, characterized in that, Both the first target (4) and the second target (5) are blood vessels; or, The first target (4) is a lymphatic vessel, and the second target (5) is a vein; or, The first target (4) is the vas deferens, and the second target (5) is the epididymis.

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