Acne removal composition and preparation method thereof

Abstract

The invention discloses an acne-removing composition and a preparation method thereof. The acne removing composition is mainly prepared from a fructus forsythiae (FORSYTHIA SUSPENSA) fruit extract, a cortex phellodendri amurensis (PHELLODENDRON AMURENSE) bark extract and a fructus gleditsiae sinensis (GLEDITSIA SINNENSIS) calthrop extract, and the cortex phellodendri amurensis extract, the fructus forsythiae fruit extract, the cortex phellodendri amurensis bark extract and the fructus gleditsiae sinensis (GLEDITSIA SINNENSIS) calthrop The acne-removing composition follows the principle of clearing heat and eliminating dampness, cooling blood and detoxifying, and promoting blood circulation and removing stasis in traditional Chinese medicine, comprehensive conditioning is carried out on different acne stages (such as comedo, inflammatory papule, pustule and nodule cyst) and fundamental causes (such as excessive heat in lung and stomach, damp-heat accumulation and blood heat stasis), and a good instant and long-acting acne-removing effect can be achieved.

Description

Technical Field

[0001] This invention relates to the field of cosmetics, and in particular to an acne-removing composition and its preparation method. Background Technology

[0002] Acne, also known as pimples, is a common chronic inflammatory skin disease that primarily occurs on the cheeks, forehead, and jawline, but can also extend to the trunk, such as the chest, back, and shoulders. It is characterized by comedones, papules, pustules, nodules, cysts, and scars, accompanied by seborrhea. It is most prevalent among adolescent boys and girls, with an incidence rate as high as 54%. The causes of acne are complex, including abnormal androgen levels, excessive sebum secretion, abnormal keratinization of cells around the hair follicles, and an inflammatory response triggered by Propionibacterium acnes.

[0003] Existing acne treatment products primarily rely on the addition of natural plant ingredients with anti-inflammatory and antibacterial properties to achieve these effects. By killing bacteria in the pimples, inhibiting bacterial growth, and reducing bacterial metabolites, they help reduce inflammation and gradually clear up the pimples. While killing and inhibiting bacteria can indeed make pimples disappear, it usually only treats the symptoms, not the root cause. Once the antibacterial and anti-inflammatory effects wear off, bacteria will multiply again, leading to frequent recurrences. This results in a high degree of dependence on acne treatment products, requiring continuous use. Furthermore, as bacteria continue to multiply, tolerance can develop, causing the effectiveness of a particular acne treatment product to gradually decrease after a period of use.

[0004] Natural plants are widely used in skincare due to their unique bioactivity and gentleness. Plant extracts are typically rich in various active ingredients, such as alkaloids, flavonoids, and polyphenols, which excel at inhibiting bacterial growth, reducing inflammation, and promoting skin repair. However, the effects of a single plant extract are often limited, requiring combination with multiple plant extracts to achieve synergistic effects.

[0005] Following extensive research in the field of acne treatment, the inventors of this invention developed an acne-removing composition that adheres to the principles of traditional Chinese medicine: "clearing heat and removing dampness, cooling blood and detoxifying, and promoting blood circulation and resolving stagnation." This composition comprehensively addresses different stages of acne (pimples, inflammatory papules, pustules, nodules and cysts) and their root causes (excessive heat in the lungs and stomach, damp-heat accumulation, and blood stasis), achieving both immediate and long-lasting acne-removing effects, thus completing this invention. Summary of the Invention

[0006] In view of this, the present invention provides an acne-removing composition that follows the principles of traditional Chinese medicine, namely "clearing heat and removing dampness, cooling blood and detoxifying, and promoting blood circulation and resolving lumps". It comprehensively regulates different stages of acne (pustules, inflammatory papules, pustules, nodules and cysts) and their root causes (excessive heat in the lungs and stomach, damp-heat accumulation, and blood heat stagnation), and can achieve good immediate and long-lasting acne-removing effects.

[0007] The acne-removing composition of the present invention mainly contains: Forsythia suspensa fruit extract, Phellodendron amurense bark extract, and Gleditsia sinensis thorn extract.

[0008] The forsythia involved in this invention is the mature fruit of the forsythia shrub, belonging to the genus Forsythia of the Oleaceae family. Forsythia has the effects of clearing heat and detoxifying, reducing swelling and dissipating nodules. It is one of the traditional Chinese medicines commonly used in clinical practice in China, often used to treat acute wind-heat colds, lymph node tuberculosis, and other symptoms.

[0009] The *Phellodendron* species involved in this invention is a deciduous tree belonging to the genus *Phellodendron* in the Rutaceae family. Its inner bark, after processing, is used medicinally and is called *Phellodendron*. It has a bitter taste and cold properties. It clears heat and detoxifies, drains fire and dries dampness. It is mainly used to treat acute bacterial dysentery, acute enteritis, acute jaundice hepatitis, urinary tract infections, and other inflammatory conditions. Externally, it is used to treat burns, otitis media, and acute conjunctivitis.

[0010] The thorns of the soapberry tree involved in this invention, also known as soapberry thorns, are the dried thorns of the soapberry plant (Gleditsia sinensis). According to *Compendium of Materia Medica*, soapberry thorns draw out toxins and dispel wind. For carbuncles and boils that have not yet formed, they can be drawn to disperse; for those about to rupture, they can be drawn to bring forth the head; and for those that have already ulcerated, they can be drawn to promote pus drainage. It is a primary remedy among medicines for sores and boils. It also drains wind-heat and wind-toxins from the blood; therefore, it is also considered a vanguard in medicines for treating severe wind-related ailments.

[0011] This invention also discloses a method for preparing the acne-removing composition, comprising the following steps: (1) Weigh the following raw materials by weight: 1-10 parts of Forsythia fruit, 1-10 parts of Phellodendron bark, and 1-10 parts of Gleditsia sinensis thorns, dry and pulverize them to obtain Chinese medicine powder; (2) Add water and cellulase to the Chinese medicine powder, mix well, fully enzymatically hydrolyze, filter and collect the residue, and drain. (3) Mix glycerophosphate choline, lactic acid and butanediol, heat and dissolve into a transparent and homogeneous solvent; mix the filter residue with 10-15 times the weight of the filter residue in the solvent; heat to 75-85℃, stir and extract for 30-60 minutes under the assistance of 200-400W ultrasound, centrifuge while hot, and take the supernatant. (4) Dilute the supernatant with water 1-5 times, adjust the pH to 7.0-8.0, add diatomaceous earth, heat to 50-60℃, stir for 30-60 minutes; filter with a filter press to obtain a clear liquid with a lighter color, which is the acne treatment composition.

[0012] In one embodiment, the raw materials are in the following weight parts: 8 parts forsythia fruit, 5 parts phellodendron bark, and 3 parts soapberry thorns.

[0013] In some embodiments, the amount of water added is 5-10 times that of the Chinese medicine powder, and the amount of cellulase added is 1-5‰ of the Chinese medicine powder.

[0014] In some of these embodiments, the enzymatic hydrolysis is performed by slow stirring at 25-30°C for 1-3 hours.

[0015] In some embodiments, the molar ratio of glycerophosphate choline, lactic acid, and butylene glycol is 1:2:3-5.

[0016] In some embodiments, the amount of diatomaceous earth added is 1-3% of the weight of the supernatant.

[0017] The acne-removing composition described in this invention can be used as an active ingredient in cosmetic formulations.

[0018] This invention also discloses a refreshing acne cream, comprising the following components in weight percentage: 0.5% bis-PEG / PPG-14 / 14 polydimethylsiloxane, 0.5% PEG-10 polydimethylsiloxane, 8% polydimethylsiloxane, 3% polydimethylsiloxane / vinyl polydimethylsiloxane crosspolymer, 4% isododecane, 5% glycerin, 5-10% of the above-mentioned acne-removing composition, 0.5% hexanediol, 0.5% p-hydroxyacetophenone, and the balance being water.

[0019] The beneficial effects of the technical solution provided by the embodiments of the present invention are as follows: This invention uses a formula of three medicinal herbs—Forsythia fruit, Phellodendron bark, and Gleditsia sinensis thorns—to treat acne. The formula focuses on clearing heat and drying dampness, while addressing detoxification and dissipating nodules, supplemented by guiding the medicine through the meridians to promote pus drainage, collectively aiming to clear acne and prevent recurrence. Specifically, Forsythia fruit is the principal herb, clearing heat and detoxifying, and dissipating nodules. Forsythia is cool in nature and bitter in taste, able to clear the heat and toxins permeating the skin, controlling the inflammatory environment of acne hominis as a whole. For existing red, swollen, and even hardened inflammatory acne, Forsythia has a powerful effect of dissipating nodules and reducing swelling, promoting the softening and dissipation of nodules. Phellodendron bark is the assistant herb, clearing heat and drying dampness, purging fire and eliminating steaming. Phellodendron is extremely bitter and cold, with a descending nature, especially good at clearing damp heat in the lower burner. At the skin level, it can effectively remove the "damp turbidity" of the skin (manifested as excessive sebum secretion and viscous pus). For acne caused by "internal heat rising" due to staying up late and high stress, Phellodendron bark can guide the heat downwards, fundamentally reducing acne occurrence. Gleditsia sinensis thorns are used as an adjuvant to penetrate and drain pus, guiding the medicine to the surface. For acne that has already suppurated with white pustules, Forsythia suspensa and Phellodendron bark act as the "encirclement and suppression," while Gleditsia sinensis thorns are the "vanguard." Their sharpness allows them to directly reach the affected area, penetrate the skin, break open the boil, and promote pus drainage. This "gives the pathogen an outlet," as the swelling quickly subsides and healing accelerates after the pus is drained. Gleditsia sinensis thorns possess powerful "penetrating" and "drifting" properties; they act as a "guide," leading the medicinal power of Forsythia suspensa and Phellodendron bark to more effectively reach the skin's texture and deep into the hair follicles, directly acting on the lesion. This is like a "precision-guided missile," greatly improving the targeting and efficacy of the entire formula. In summary, the formula, composed of forsythia fruit, phellodendron bark, and soapberry thorns, is effective for treating inflammatory papules with redness and swelling without a head, where the heat-clearing and anti-inflammatory effects of forsythia and phellodendron are dominant. For pimples with pustules, the pus-draining effect of soapberry thorns is fully utilized. For deep-seated, indurated cystic pimples, the combined effect of the three herbs—soapberry thorns guiding the medicine deeper, forsythia dispersing nodules, and phellodendron reducing inflammation—effectively promotes their resolution. Attached Figure Description

[0020] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the accompanying drawings used in the description of the embodiments or the prior art are briefly introduced below.

[0021] Figure 1 The second test involved consumer trials to assess the acne-removing effectiveness of each test group. Detailed Implementation

[0022] This invention discloses an acne-removing composition. Those skilled in the art can refer to this document and appropriately modify the process parameters to achieve the desired result. It should be particularly noted that all similar substitutions and modifications are obvious to those skilled in the art and are considered to be included in this invention. The methods and applications of this invention have been described through preferred embodiments. Those skilled in the art can obviously make modifications or appropriate alterations and combinations to the methods and applications described herein without departing from the content, spirit, and scope of this invention to implement and apply the technology of this invention.

[0023] The raw materials and reagents used in the acne-removing composition provided by this invention can be purchased from the market.

[0024] The present invention will be further illustrated below with reference to the embodiments: Example

[0025] An acne-removing composition is prepared by the following steps: (1) Weigh the following raw materials by weight: 1 part of Forsythia fruit, 10 parts of Phellodendron bark, and 1 part of Gleditsia sinensis thorns, dry and pulverize them to obtain Chinese medicine powder; (2) Add 10 times its weight of water and 1‰ of cellulase to the Chinese medicine powder, mix well, stir slowly at 30℃ for 1 hour to fully hydrolyze the enzyme, filter and collect the residue, and drain. (3) Mix glycerophosphate choline, lactic acid and butanediol in a molar ratio of 1:2:5 and heat to dissolve into a transparent and homogeneous solvent; mix the filter residue with 10 times the weight of the solvent; heat to 85°C and extract for 60 min with ultrasonic assistance at 200W; centrifuge while hot and take the supernatant. (4) Dilute the supernatant with water by 1:1, adjust the pH to 8.0, add 1% of the weight of diatomaceous earth to the supernatant, heat to 60°C and stir for 30 minutes; filter with a filter press to obtain a clear liquid with a lighter color, which is the acne treatment composition. Example

[0026] An acne-removing composition is prepared by the following steps: (1) Weigh the following raw materials by weight: 10 parts of Forsythia fruit, 1 part of Phellodendron bark, and 10 parts of Gleditsia sinensis thorns, dry and pulverize them to obtain Chinese medicine powder; (2) Add 5 times its weight of water and 5‰ of cellulase to the Chinese medicine powder, mix well, stir slowly at 25℃ for 3 hours to fully enzymatically hydrolyze, filter and collect the residue, and drain. (3) Mix glycerophosphate choline, lactic acid and butanediol in a molar ratio of 1:2:3 and heat to dissolve into a transparent and homogeneous solvent; mix the filter residue with 15 times the weight of the solvent; heat to 75°C and stir for 30 min under the assistance of 400W ultrasound; centrifuge while hot and take the supernatant. (4) Dilute the supernatant with water 5 times, adjust the pH to 7.0, add 3% of the weight of the supernatant diatomaceous earth, heat to 50°C and stir for 60 minutes; filter with a filter press to obtain a clear liquid with a lighter color, which is the acne treatment composition. Example

[0027] An acne-removing composition is prepared by the following steps: (1) Weigh the following raw materials in parts by weight: 8 parts of Forsythia fruit, 5 parts of Phellodendron bark, and 3 parts of Gleditsia sinensis thorns. Dry and pulverize them to obtain Chinese medicine powder. (2) Add 8 times its weight of water and 3‰ of cellulase to the Chinese medicine powder, mix well, stir slowly at 27℃ for 2 hours to fully enzymatically hydrolyze, filter and collect the residue, and drain. (3) Mix glycerophosphate choline, lactic acid and butanediol in a molar ratio of 1:2:4 and heat to dissolve into a transparent and homogeneous solvent; mix the filter residue with 12 times the weight of the solvent; heat to 80°C and stir for 40 min under the assistance of 300W ultrasound; centrifuge while hot and take the supernatant. (4) Dilute the supernatant with water 3 times, adjust the pH to 7.5, add 2% of the weight of the supernatant diatomaceous earth, heat to 55°C and stir for 40 minutes; filter with a filter press to obtain a clear liquid with a lighter color, which is the acne treatment composition. Example

[0028] A refreshing acne cream comprises the following components in weight percentages: 0.5% bis-PEG / PPG-14 / 14 polydimethylsiloxane, 0.5% PEG-10 polydimethylsiloxane, 8% polydimethylsiloxane, 3% polydimethylsiloxane / vinyl polydimethylsiloxane crosspolymer, 4% isododecane, 5% glycerin, 5% the acne composition prepared in Example 1, 0.5% hexanediol, 0.5% p-hydroxyacetophenone, and the balance being water. Example

[0029] A refreshing acne cream comprises the following components in weight percentages: 0.5% bis-PEG / PPG-14 / 14 polydimethylsiloxane, 0.5% PEG-10 polydimethylsiloxane, 8% polydimethylsiloxane, 3% polydimethylsiloxane / vinyl polydimethylsiloxane crosspolymer, 4% isododecane, 5% glycerin, 10% the acne composition prepared in Example 2, 0.5% hexanediol, 0.5% p-hydroxyacetophenone, and the balance being water.

[0030] Comparative Example 1 A refreshing acne cream comprises the following components in weight percentages: 1% bis-PEG / PPG-14 / 14 polydimethylsiloxane, 8% polydimethylsiloxane, 3% polydimethylsiloxane / vinyl polydimethylsiloxane crosspolymer, 4% isododecane, 5% glycerin, 10% the acne composition prepared in Example 2, 0.5% hexanediol, 0.5% p-hydroxyacetophenone, and the balance being water.

[0031] Comparative Example 2 A refreshing acne cream comprises the following components in weight percentages: 1% PEG-10 polydimethylsiloxane, 8% polydimethylsiloxane, 3% polydimethylsiloxane / vinyl polydimethylsiloxane crosspolymer, 4% isododecane, 5% glycerin, 10% the acne composition prepared in Example 2, 0.5% hexanediol, 0.5% p-hydroxyacetophenone, and the balance being water.

[0032] Test 1 Stability Test The stability of the refreshing acne-removing creams prepared in Examples 4-5 and Comparative Examples 1-2 was tested. The tests were conducted according to the W / O type heat and cold resistance standards recorded in the industry standard QB / T 1857-2004 Moisturizing Creams. Specifically, the oil seepage rate was ≤3% after maintaining a temperature of (40±1)℃ for 24 hours and then returning to room temperature; and the product was kept at -5℃ to -10℃ for 24 hours and then returned to room temperature with no significant difference in properties compared to before the test. If the test met the above standards, it was recorded as qualified; otherwise, it was unqualified. Specific test results are shown in Table 1.

[0033] Table 1 Stability Test Results

[0034] As can be seen from Table 1, the refreshing acne cream prepared in the embodiments of the present invention has good stability.

[0035] Test 2: Consumer Trial Test Consumer trial tests were conducted in accordance with the methods described in the group standard "T / TDCA 004—2021 Test Method for Acne-Removing Efficacy of Cosmetics" published by the Tianjin Daily Chemical Products Association.

[0036] Part 1: Test Samples

[0037] Example 5 was used as the test sample, and comparative examples 3-4 were set up.

[0038] Comparative Example 3 A refreshing acne cream comprises the following components in weight percentages: 0.5% bis-PEG / PPG-14 / 14 polydimethylsiloxane, 0.5% PEG-10 polydimethylsiloxane, 8% polydimethylsiloxane, 3% polydimethylsiloxane / vinyl polydimethylsiloxane crosspolymer, 4% isododecane, 5% glycerin, 10% acne-removing composition, 0.5% hexanediol, 0.5% p-hydroxyacetophenone, and the balance being water; The acne-removing composition is prepared through the following steps: (1) Weigh the following raw materials in parts by weight: 8 parts of Forsythia fruit, 5 parts of Phellodendron bark, and 3 parts of Gleditsia sinensis thorns. Dry and pulverize them to obtain Chinese medicine powder. (2) Add 8 times its weight of water and 3‰ of cellulase to the Chinese medicine powder, mix well, stir slowly at 27℃ for 2 hours to fully enzymatically hydrolyze, filter and collect the residue, and drain. (3) Mix lactic acid and butanediol in a molar ratio of 3:3 and heat to dissolve into a transparent and homogeneous solvent; mix the filter residue with 12 times the weight of the solvent; heat to 80°C and extract for 40 min with ultrasonic assistance at 300W; centrifuge while hot and take the supernatant. (4) Dilute the supernatant with water 3 times, adjust the pH to 7.5, add 2% of the weight of the supernatant diatomaceous earth, heat to 55°C and stir for 40 minutes; filter with a filter press to obtain a clear liquid with a lighter color, which is the acne treatment composition.

[0039] Comparative Example 4 A refreshing acne cream comprises the following components in weight percentages: 0.5% bis-PEG / PPG-14 / 14 polydimethylsiloxane, 0.5% PEG-10 polydimethylsiloxane, 8% polydimethylsiloxane, 3% polydimethylsiloxane / vinyl polydimethylsiloxane crosspolymer, 4% isododecane, 5% glycerin, 10% acne-removing composition, 0.5% hexanediol, 0.5% p-hydroxyacetophenone, and the balance being water; The acne-removing composition is prepared through the following steps: (1) Weigh the following raw materials in parts by weight: 8 parts of Forsythia fruit, 5 parts of Phellodendron bark, and 3 parts of Gleditsia sinensis thorns. Dry and pulverize them to obtain Chinese medicine powder. (2) Add 8 times its weight of water and 3‰ of cellulase to the Chinese medicine powder, mix well, stir slowly at 27℃ for 2 hours to fully enzymatically hydrolyze, filter and collect the residue, and drain. (3) Mix glycerophosphate choline and butanediol in a molar ratio of 3:3 and heat to dissolve into a transparent and homogeneous solvent; mix the filter residue with 12 times the weight of the solvent; heat to 80°C and extract for 40 min with ultrasonic assistance at 300W; centrifuge while hot and take the supernatant. (4) Dilute the supernatant with water 3 times, adjust the pH to 7.5, add 2% of the weight of the supernatant diatomaceous earth, heat to 55°C and stir for 40 minutes; filter with a filter press to obtain a clear liquid with a lighter color, which is the acne treatment composition.

[0040] Part Two: Test Methods and Results The specific method was as follows: Ninety volunteers aged 18-28 were recruited and randomly divided into three groups of 30 each. Volunteers had a certain number of acne spots on their facial skin, but these could not be nodules or cysts that were difficult to improve with clinical agents. Before the test, a visual assessment method was used, with laboratory researchers counting the acne spots on the participants' faces. The product usage method was as follows: After cleansing, take an appropriate amount of the refreshing acne cream, apply it evenly to the face, and gently massage in circular motions until fully absorbed. Use it twice a day, morning and evening, for one week. After one week, volunteers were followed up, and a visual assessment method was used again, with laboratory researchers counting the acne spots on the participants' faces. A reduction of more than 50% in acne spots compared to before the test was considered effective. The effectiveness rate for each test group was calculated. Specific test results are attached. Figure 1 .

[0041] From the appendix Figure 1 It can be seen that the refreshing acne cream prepared in the embodiments of the present invention achieves a good acne removal effect.

[0042] The above description is only a preferred embodiment of the present invention. It should be noted that for those skilled in the art, several improvements and modifications can be made without departing from the principle of the present invention, and these improvements and modifications should also be considered within the scope of protection of the present invention.

Claims

1. An acne-removing composition, characterized in that, It mainly contains: Forsythia suspensa fruit extract, Phellodendron amurense bark extract, and Gleditsia sinensis thorn extract.

2. A method for preparing the acne-removing composition as described in claim 1, characterized in that, Includes the following steps: (1) Weigh the following raw materials by weight: 1-10 parts of Forsythia fruit, 1-10 parts of Phellodendron bark, and 1-10 parts of Gleditsia sinensis thorns, dry and pulverize them to obtain Chinese medicine powder; (2) Add water and cellulase to the Chinese medicine powder, mix well, fully enzymatically hydrolyze, filter and collect the residue, and drain. (3) Mix glycerophosphate choline, lactic acid and butanediol, heat and dissolve into a transparent and homogeneous solvent; mix the filter residue with 10-15 times the weight of the filter residue in the solvent; heat to 75-85℃, stir and extract for 30-60 minutes under the assistance of 200-400W ultrasound, centrifuge while hot, and take the supernatant. (4) Dilute the supernatant with water 1-5 times, adjust the pH to 7.0-8.0, add diatomaceous earth, heat to 50-60℃, stir for 30-60 minutes; filter with a filter press to obtain a clear liquid with a lighter color, which is the acne treatment composition.

3. The method for preparing the acne-removing composition according to claim 2, characterized in that, The raw materials are in the following weight proportions: 8 parts forsythia fruit, 5 parts phellodendron bark, and 3 parts soapberry thorns.

4. The method for preparing the acne-removing composition according to claim 2, characterized in that, The amount of water added is 5-10 times that of the Chinese medicine powder, and the amount of cellulase added is 1-5‰ of the Chinese medicine powder.

5. The method for preparing the acne-removing composition according to claim 2, characterized in that, The enzymatic hydrolysis is carried out by slow stirring at 25-30℃ for 1-3 hours.

6. The method for preparing the acne-removing composition according to claim 2, characterized in that, The molar ratio of glycerophosphate choline, lactic acid, and butylene glycol is 1:2:3-5.

7. The method for preparing the acne-removing composition according to claim 2, characterized in that, The amount of diatomaceous earth added is 1-3% of the weight of the supernatant.

8. The use of the acne-removing composition according to claim 1 in the preparation of cosmetics.

9. A refreshing acne-removing cream, characterized in that, The composition comprises the following components in weight percentages: 0.5% bis-PEG / PPG-14 / 14 polydimethylsiloxane, 0.5% PEG-10 polydimethylsiloxane, 8% polydimethylsiloxane, 3% polydimethylsiloxane / vinyl polydimethylsiloxane crosspolymer, 4% isododecane, 5% glycerin, 5-10% of the acne-removing composition of claim 1, 0.5% hexanediol, 0.5% p-hydroxyacetophenone, and the balance being water.

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