Composite nanomaterial, preparation method and application thereof
CN120960404BActive Publication Date: 2026-08-28HENAN ACADEMY OF SCIENCES ORGANOID CHIP & DRUG TRANSLATION RESEARCH INSTITUTE +1
Patent Information
- Application Number
- CN202511048643.8
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2025-07-29
- Publication Date
- 2026-08-28
- Estimated Expiration
- 2045-07-29
AI Technical Summary
Technical Problem
所述的复合纳米材料为基于分子动力学和酶微环境工程模拟的肿瘤协同治疗体系，旨在解决现有CDT或ST+CDT疗法仍然存在外源性金属物质的摄入而可能引发机体不良副反应的问题
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Figure CN120960404B_ABST
Abstract
The application discloses a kind of composite nanomaterial and its preparation method and application, belong to biological medicine technical field.The composite nanomaterial includes: metal organic framework and glucose oxidase (GOx) and polymer modified catalase (CAT) inside the metal organic framework.The CAT covalently modified by polymer, on the one hand, can efficiently catalyze hydrogen peroxide (H2O2) decomposition into O2 and H2O, on the other hand, can efficiently catalyze H2O2 conversion into high toxicity ·OH.The composite nanomaterial, on the one hand, can generate gluconic acid and H2O2 by the GOx catalysis glucose and O2, the H2O2 is decomposed into water and O2 by the CAT further promote glucose consumption, on the other hand, is converted into high toxicity ·OH by the CAT, has significant inhibitory effect on tumor growth, has broad application prospect in tumor treatment.
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Citation Information
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