Anti-allergic composition for reducing irritation of 4-butylresorcinol and salicylic acid

Abstract

The invention belongs to the technical field of cosmetics, and particularly relates to an anti-allergic composition for reducing irritation of 4-butylresorcinol and salicylic acid. The opuntia ficus-indica, the radix scutellariae alpinae and the pomelo fruit extract are rich in antioxidant components, free radicals can be removed, damage of oxidative stress to skin cells is reduced, senescence is delayed, release of inflammatory factors is synergistically inhibited, and sensitive symptoms such as skin redness are relieved. The polyhydric alcohol solvent and the phospholipid emulsifier can improve the solubility and the stability of the 4-butylresorcinol. And the nonionic emulsifier is beneficial to formation of a stable emulsification system, so that the uniformity and stability of the composition are improved. The cyclic polysaccharide has good moisturizing and film-forming properties, and can enhance the moisturizing effect and skin adhesion of the composition. The moisturizing agent and the antioxidant further improve the moisturizing and oxidation resistance of the composition.

Description

Technical Field

[0001] This invention belongs to the field of cosmetic technology, specifically relating to an anti-allergic composition that reduces the irritation of 4-butylresorcinol and salicylic acid. Background Technology

[0002] In the cosmetics industry, 4-butylresorcinol is an effective whitening ingredient that can inhibit melanin production and has excellent antioxidant properties. Salicylic acid is a common acne-fighting ingredient with anti-inflammatory and exfoliating effects. However, the application of both in cosmetics also presents some challenges. 4-Butylresorcinol is only slightly soluble in water and is highly irritating, requiring specific formulation techniques to improve its solubility and reduce irritation. Salicylic acid is insoluble in water and has extremely poor solubility in alcohol, and can cause skin irritation, especially at high concentrations. When using cosmetics containing 4-butylresorcinol and salicylic acid, many consumers, especially those with sensitive skin, experience adverse reactions such as redness, peeling, and barrier damage. This not only affects the user experience but also limits the application of these active ingredients in cosmetics suitable for sensitive skin.

[0003] Currently, commonly used anti-allergy agents on the market, such as bisabolol and dipotassium glycyrrhizate, while able to alleviate skin irritation symptoms to some extent, have significant shortcomings. On the one hand, these traditional anti-allergy agents may antagonize the activity of 4-butylresorcinol and salicylic acid, thereby reducing the whitening and anti-acne effects of cosmetics. On the other hand, traditional anti-allergy agents often lack multi-pathway repair mechanisms, only providing symptom relief without fundamentally addressing skin inflammation, oxidative stress, and barrier damage. Therefore, there is a lack of existing technologies that can effectively neutralize the chemical irritation of 4-butylresorcinol and salicylic acid while simultaneously possessing multiple functions such as anti-inflammation, anti-oxidation, and barrier repair to meet the needs of people with sensitive skin for highly effective yet gentle cosmetics. Summary of the Invention

[0004] The purpose of this invention is to address the existing problems by providing an anti-allergic composition that reduces the irritation of 4-butylresorcinol and salicylic acid.

[0005] This invention is achieved through the following technical solution:

[0006] An anti-allergic composition for reducing the irritation of 4-butylresorcinol and salicylic acid, comprising the following components in parts by weight:

[0007] 4-Butylresorcinol 5-10 parts, salicylic acid 2-8 parts, Prunus persica stem extract 1-5 parts, grapefruit fruit extract 1-5 parts, Scutellaria baicalensis flower / leaf / stem extract 0.5-3 parts, polyol solvent 15-30 parts, phospholipid emulsifier 3-8 parts, nonionic emulsifier 15-40 parts, cyclic polysaccharide 3-10 parts, humectant 0.5-5 parts, antioxidant 0.1-2 parts, balance is water, total 100 parts.

[0008] Furthermore, the preparation method of the *Opuntia ficus-indica* stem extract is as follows:

[0009] (1) Take fresh Prunus persica stem, wash it, remove the skin and cut it into thin slices. Dry it under vacuum at 40-50℃ until the moisture content is <6%, then pulverize it through an 80-100 mesh sieve to obtain Prunus persica stem powder.

[0010] (2) Mix cactus stem powder with an ethanol aqueous solution of 20-40% by volume at a material-liquid ratio of 1:15-20, and perform ultrasonic-assisted extraction at 60-70℃ for 40-60 min at 200-300W.

[0011] (3) After filtering the extract, concentrate it under reduced pressure at 50-60℃ and -0.08--0.09MPa to 1 / 5-1 / 10 of the original volume, and then freeze dry it.

[0012] Furthermore, the preparation of the extract of Scutellaria baicalensis flowers / leaves / stems includes the following steps:

[0013] 1) Collect the flowers, leaves and stems of Scutellaria baicalensis from the mountains, remove impurities and dry them in the dark at 35-40℃ until the moisture content is <6%, then pulverize them through a 60-80 mesh sieve to obtain Scutellaria baicalensis raw powder;

[0014] 2) Mix the raw material powder of Scutellaria baicalensis with an aqueous ethanol solution of 60-70% by volume at a material-to-liquid ratio of 1:10-12, and reflux extract at 70-75℃ for 2-3 times, with each extraction time being 1-2 hours. Combine the extracts and concentrate under reduced pressure at 60-65℃ and -0.08--0.09 MPa until there is no alcohol odor. Then purify using AB-8 macroporous adsorption resin. Concentrate the resulting eluent under reduced pressure at 50-55℃ and -0.08--0.09 MPa until it becomes a thick paste without alcohol odor, and then freeze-dry it.

[0015] Furthermore, the preparation of the grapefruit extract includes the following steps:

[0016] ① Take fresh pomelo, wash it, separate the peel and pulp, mash the pulp, filter it coarsely with gauze, collect the filtrate and pasteurize it for later use, dry the peel at 40-50℃ until brittle, and crush it through a 40-60 mesh sieve to obtain peel powder.

[0017] ② Extract the fruit peel powder with a 50-70% ethanol aqueous solution at a material-to-liquid ratio of 1:10-15, reflux at 70-75℃ for 2-3 times, with each extraction lasting 1-2 hours. Combine the extracts and concentrate under reduced pressure at 60-65℃ and -0.08--0.09 MPa until no alcohol odor is detected to obtain a concentrated fruit peel solution.

[0018] ③ Combine the pasteurized filtrate from step ① and the fruit peel concentrate obtained in step ②, concentrate under reduced pressure at 50-55℃ and -0.08--0.09MPa until it becomes a thick paste, and then freeze-dry it.

[0019] Furthermore, the polyol solvent is selected from one or more of 1,2-propanediol, 1,3-propanediol, butanediol, 1,2-pentanediol, and 1,2-hexanediol.

[0020] Furthermore, the phospholipid emulsifier is selected from one or more of lecithin, phosphatidylcholine, sphingomyelin, hydrogenated lecithin, and lysophosphatidylcholine.

[0021] Furthermore, the nonionic emulsifier is selected from one or more of PEG-20 hydrogenated castor oil, PEG-40 hydrogenated castor oil, polysorbate-20, polysorbate-80, cetearyl alcohol polyether-20, polyglycerol-10 distearate, polyglycerol-10 myristate, and polyglycerol-10 oleate.

[0022] Furthermore, the moisturizer is selected from one or more of sodium hyaluronate, trehalose, inositol, mannose, and betaine;

[0023] The antioxidant is selected from one or more of vitamin E, tea polyphenols, ascorbic acid, and rosemary leaf extract.

[0024] Furthermore, the cyclic polysaccharide is selected from one or more of cyclodextrin, hydroxypropyl cyclodextrin, chitosan, and carrageenan.

[0025] A method for preparing an anti-allergic composition that reduces the irritation of 4-butylresorcinol and salicylic acid includes the following steps:

[0026] S1. Add polyol, phospholipid emulsifier, nonionic emulsifier and antioxidant to the reaction vessel, heat to 70-80℃, and stir evenly at 50-60 rpm;

[0027] When the temperature is lowered to 50-55℃, 4-butylresorcinol is added, and the mixture is stirred at 40-50 rpm until homogeneous. Then the temperature is lowered to 38-45℃ to obtain the emulsion matrix.

[0028] S2. The cyclic polysaccharide was dissolved in deionized water at 60℃ and stirred until clear to obtain an aqueous solution of the cyclic polysaccharide; simultaneously, salicylic acid was dissolved in ethanol and sonicated to obtain an ethanolic solution of salicylic acid; the ethanolic solution of salicylic acid was added dropwise to the aqueous solution of the cyclic polysaccharide under stirring at 60℃ and 600 rpm, and the reaction was continued for 6 hours; after cooling to room temperature, it was refrigerated at 4℃ for 12 hours, and the precipitate was collected by suction filtration; the precipitate was washed three times with a pre-cooled ethanol-water mixture (volume ratio of 1:1) at 5℃; the filter cake was vacuum dried at 40℃ for 12 hours to obtain supramolecularly encapsulated salicylic acid;

[0029] S3. At room temperature, add supramolecularly encapsulated salicylic acid, Prunus persica stem extract, grapefruit extract, Scutellaria baicalensis flower / leaf / stem extract, and humectant to water, stir well, and prepare an aqueous solution.

[0030] S4. Add the aqueous solution to the emulsion matrix and keep stirring to fully mix the two phases and form a uniform emulsion mixture. Then, process the mixture three times using a high-pressure microjet machine to produce uniform liposomes with a particle size of 10-100 nm. The pressure value is controlled at 10,000-30,000 psi.

[0031] Application of a composition for reducing the irritation and allergy of 4-butylresorcinol and salicylic acid in the preparation of cosmetics with whitening, anti-inflammatory and acne-removing effects.

[0032] The present invention has the following advantages over the prior art:

[0033] 1. The extracts of Prunus persica, Scutellaria baicalensis, and pomelo fruit of this invention are rich in antioxidants, which can scavenge free radicals, reduce the damage of oxidative stress to skin cells, delay aging, synergistically inhibit the release of inflammatory factors, and alleviate sensitive symptoms such as skin redness and itching.

[0034] 2. The polyol solvent and phospholipid emulsifier of this invention can improve the solubility and stability of 4-butylresorcinol. The nonionic emulsifier helps to form a stable emulsion system, improving the uniformity and stability of the composition. The cyclic polysaccharide has good moisturizing and film-forming properties, enhancing the moisturizing effect and skin adhesion of the composition. The humectant and antioxidant further improve the moisturizing and antioxidant properties of the composition. Detailed Implementation

[0035] To further explain the present invention, the following specific embodiments are described.

[0036] Unless otherwise specified, the raw materials used in this invention are all from commercially available conventional products.

[0037] Example 1

[0038] An anti-allergic composition for reducing the irritation of 4-butylresorcinol and salicylic acid, comprising the following components by weight:

[0039] 5 parts of 4-butylresorcinol

[0040] - 2 parts salicylic acid

[0041] - 1 part of Prunus persica stem extract

[0042] - 1 part grapefruit extract

[0043] -0.5 parts of extract from the flower, leaf, and stem of Scutellaria baicalensis (Alpine Scutellaria).

[0044] - 15 parts of polyol solvent (1,2-propanediol)

[0045] - 3 parts phospholipid emulsifier (lecithin)

[0046] - 15 parts nonionic emulsifier (PEG-40 hydrogenated castor oil)

[0047] - 3 parts of cyclic polysaccharide (hydroxypropyl cyclodextrin)

[0048] - 0.5 parts moisturizer (betaine)

[0049] - 0.1 parts antioxidant (vitamin E)

[0050] - Remaining water

[0051] Example 2 (corresponding to Comparative Example 1)

[0052] An anti-allergic composition for reducing the irritation of 4-butylresorcinol and salicylic acid, comprising the following components by weight:

[0053] 6 parts of 4-butylresorcinol

[0054] - 4 parts salicylic acid

[0055] -1.5 parts of Prickly Pear Cactus Stem Extract

[0056] - 1.5 parts grapefruit extract

[0057] -0.6 parts of extract from the flower, leaf, and stem of Scutellaria baicalensis (Alpine Scutellaria).

[0058] 18 parts of -1,2-propanediol

[0059] -5 parts lecithin

[0060] 20 parts PEG-40 hydrogenated castor oil

[0061] 4 parts of hydroxypropyl cyclodextrin

[0062] - 0.5 parts betaine

[0063] - Vitamin E 0.3 servings

[0064] - Remaining water

[0065] Example 3

[0066] An anti-allergic composition for reducing the irritation of 4-butylresorcinol and salicylic acid, comprising the following components by weight:

[0067] 8 parts of 4-butylresorcinol

[0068] -5 parts salicylic acid

[0069] - 2 portions of Prunus persica stem extract

[0070] - 2 portions of grapefruit extract

[0071] -0.8 parts of extract from the flower, leaf, and stem of Scutellaria baicalensis (Alpine Scutellaria).

[0072] 20 parts of 1,2-propanediol

[0073] - 6 parts lecithin

[0074] 25 parts PEG-40 hydrogenated castor oil

[0075] 5 parts of hydroxypropyl cyclodextrin

[0076] - 0.5 parts betaine

[0077] - Vitamin E 0.5 parts

[0078] - Remaining water

[0079] Example 4

[0080] An anti-allergic composition for reducing the irritation of 4-butylresorcinol and salicylic acid, comprising the following components by weight:

[0081] 10 parts of 4-butylresorcinol

[0082] -6 parts salicylic acid

[0083] - 2.5 parts of Prickly Pear Cactus Stem Extract

[0084] - Grapefruit extract 2.5 parts

[0085] -0.9 parts of extract from the flower, leaf, and stem of Scutellaria baicalensis (Alpine Scutellaria).

[0086] 28 parts of 1,2-propanediol

[0087] -7 parts lecithin

[0088] -28 parts PEG-40 hydrogenated castor oil

[0089] 8 parts of hydroxypropyl cyclodextrin

[0090] - 1 part betaine

[0091] - Vitamin E 0.8 parts

[0092] - Remaining water

[0093] Example 5 (corresponding to Comparative Example 2, showing the best whitening effect)

[0094] An anti-allergic composition for reducing the irritation of 4-butylresorcinol and salicylic acid, comprising the following components by weight:

[0095] 10 parts of 4-butylresorcinol

[0096] -8 parts salicylic acid

[0097] - 3 portions of Prunus persica stem extract

[0098] -3 parts grapefruit extract

[0099] - 1 part of extract from Scutellaria baicalensis flower / leaf / stem

[0100] 25 parts of 1,2-propanediol

[0101] -8 parts lecithin

[0102] 30 parts PEG-40 hydrogenated castor oil

[0103] 10 parts of hydroxypropyl cyclodextrin

[0104] - 1 part betaine

[0105] -1 serving of Vitamin E

[0106] - Remaining water

[0107] The composition described in Example 1 was prepared according to the following process:

[0108] S1. Add 1,2-propanediol, lecithin, PEG-40 hydrogenated castor oil and vitamin E to the reaction vessel, heat to 70-80℃, and stir evenly at 50-60 rpm.

[0109] When the temperature is lowered to 50-55℃, 4-butylresorcinol is added, and the mixture is stirred at 40-50 rpm until homogeneous. Then the temperature is lowered to 38-45℃ to obtain the emulsion matrix.

[0110] S2. Hydroxypropyl cyclodextrin was dissolved in deionized water at 60℃ (0.01 mol hydroxypropyl cyclodextrin, 500 mL water), and stirred until clear to obtain an aqueous solution of hydroxypropyl cyclodextrin; simultaneously, salicylic acid was dissolved in ethanol (0.01 mol salicylic acid dissolved in 50 mL ethanol), and sonicated to obtain an ethanolic solution of salicylic acid; the ethanolic solution of salicylic acid was added dropwise to the aqueous solution of hydroxypropyl cyclodextrin under stirring at 60℃ and 600 rpm, and the reaction was continued for 6 h; after cooling to room temperature, it was refrigerated at 4℃ and allowed to stand for 12 h, and the precipitate was collected by suction filtration; the precipitate was washed three times with a pre-cooled ethanol-water mixture at 5℃; the filter cake was vacuum dried at 40℃ for 12 h to obtain supramolecularly encapsulated salicylic acid;

[0111] S3. At room temperature, salicylic acid encapsulated in supramolecular layers, extracts of Prunus persica stem, grapefruit extract, extracts of Scutellaria baicalensis flower / leaf / stem, and betaine were added to water and stirred until homogeneous to obtain an aqueous solution.

[0112] S4. Add the aqueous solution to the emulsion matrix and keep stirring to fully mix the two phases and form a uniform emulsion mixture. Then, process the mixture three times using a high-pressure microjet machine to produce uniform liposomes with a particle size of 10-100 nm. The pressure value is controlled at 10,000-30,000 psi.

[0113] Efficacy test

[0114] The compositions prepared in Examples 1 to 5 were subjected to efficacy tests. The results showed that the compositions had good whitening, acne-removing, and anti-inflammatory effects. Furthermore, consumer surveys and human skin patch tests showed that the compositions were gentle and non-irritating to the skin and suitable for use on various skin types.

[0115] The compositions of Examples 1 to 5 above were prepared into creams.

[0116] The formula for the cream is shown in Table 1 below.

[0117] Table 1

[0118]

[0119]

[0120] Comparative Example 1:

[0121] The component content is consistent with that of Example 5;

[0122] Comparative Example 1 Manufacturing Process:

[0123] S1. Add 1,2-propanediol, lecithin, PEG-40 hydrogenated castor oil, and vitamin E to the reaction vessel, heat to 70-80℃, and stir until homogeneous.

[0124] When the temperature drops to 50-55℃, add 4-butylresorcinol and salicylic acid, continue stirring until all components are fully dissolved, and then stir and cool to 40℃ to obtain the emulsified matrix.

[0125] S2. At room temperature, add hydroxypropyl cyclodextrin, Prunus persica stem extract, pomelo fruit extract, Scutellaria baicalensis flower / leaf / stem extract, and trehalose to an appropriate amount of water, stir well, and prepare an aqueous solution.

[0126] S3. Slowly add the aqueous solution to the emulsion matrix while stirring to ensure thorough mixing of the two phases and the formation of a homogeneous emulsion system.

[0127] The difference from the example is that supramolecular self-assembly is not performed, and supramolecularly encapsulated salicylic acid cannot be prepared.

[0128] The resulting emulsions are ultimately produced by a high-pressure microfluidic machine, and the particle size of the emulsions cannot reach the nanoscale, thus failing to produce nanoliposomes.

[0129] Comparative Example 2:

[0130] The composition content is basically the same as in Example 5, except that no extract of Scutellaria baicalensis flower / leaf / stem is added;

[0131] Comparative Example 3:

[0132] The composition content is basically the same as in Example 5, except that no extracts of the stem of the prickly pear cactus or grapefruit extract are added.

[0133] Comparative Examples 2 and 3 were prepared using the same process as the Examples.

[0134] Human efficacy test

[0135] Example 2, Example 5, Comparative Example 1

[0136] Groups of 30 participants used the VISIA-CR facial imaging system to test their facial skin and analyze the ITA° value. The average ITA° value of the facial skin was recorded on days 0, 14, and 28. A higher ITA° value indicates brighter and whiter skin. The test results are shown in Table 2 below.

[0137] Table 2

[0138]

[0139] The results showed that the whitening effect of Example 5 was better than that of Example 2, indicating that higher concentrations have better effects; the effect of Example 5 was better than that of Comparative Example 1, indicating that the composition treated with nanoliposomes and supramolecular targeted self-assembly technology can have a better whitening effect.

[0140] Human patch test

[0141] Test product: Face creams prepared in the embodiments and comparative examples of this invention;

[0142] Participants: A total of 33 participants, including 10 males and 23 females, aged 20-35 years, who met the criteria for voluntary participation.

[0143] Experimental method: A closed-system test method was adopted. 0.02g to 0.03g of the test substance was placed in a suitable patch applicator and applied to the flexor side of the subject's arm with hypoallergenic adhesive tape. The patch was then gently pressed with the palm of the hand to ensure even application to the skin. The applicator was removed after 24 hours. Skin reactions were observed and recorded at 0.5h, 24h, and 48h.

[0144] The severity of adverse skin reactions is shown in Table 3 below.

[0145] Table 3

[0146]

[0147]

[0148] The test results are shown in Table 4 below.

[0149] Table 4

[0150]

[0151] The experimental results show that Examples 2 and 5, which were treated with supramolecular targeted self-assembly and nanoliposomes, and the compositions of Prunus persica stem extract, grapefruit extract, and Scutellaria baicalensis flower / leaf / stem extract, were non-irritating. However, in Comparative Example 1, although the composition was the same as in Example 5, it was not treated with supramolecular targeted self-assembly and nanoliposomes, and the result was still somewhat irritating. In Comparative Examples 2 and 3, which added one or two of the compositions of Prunus persica stem extract, grapefruit extract, and Scutellaria baicalensis flower / leaf / stem extract, the ointments prepared were not as mild as those in Example 5.

[0152] The above description is only a preferred embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any equivalent substitutions or modifications made by those skilled in the art within the scope of the technology disclosed in the present invention, based on the technical solution and inventive concept of the present invention, should be covered within the scope of protection of the present invention.

Claims

1. A composition for reducing the irritation and allergic reaction of 4-butylresorcinol and salicylic acid, characterized in that, It consists of the following components in parts by weight: 4-Butylresorcinol 5-10 parts, salicylic acid 2-8 parts, Prunus persica stem extract 1-5 parts, grapefruit fruit extract 1-5 parts, Scutellaria baicalensis flower / leaf / stem extract 0.5-3 parts, polyol solvent 15-30 parts, phospholipid emulsifier 3-8 parts, nonionic emulsifier 15-40 parts, cyclic polysaccharide 3-10 parts, humectant 0.5-5 parts, antioxidant 0.1-2 parts, balance is water, total 100 parts.

2. The anti-allergic composition for reducing the irritation of 4-butylresorcinol and salicylic acid according to claim 1, characterized in that, The preparation method of the *Opuntia ficus-indica* stem extract is as follows: (1) Take fresh Prunus persica stem, wash it, remove the skin and cut it into thin slices. Dry it under vacuum at 40-50℃ until the moisture content is <6%, then pulverize it through an 80-100 mesh sieve to obtain Prunus persica stem powder. (2) Mix cactus stem powder with an ethanol aqueous solution of 20-40% by volume at a material-liquid ratio of 1:15-20, and perform ultrasonic-assisted extraction at 60-70℃ for 40-60 min at 200-300W. (3) After filtering the extract, concentrate it under reduced pressure at 50-60℃ and -0.08--0.09MPa to 1 / 5-1 / 10 of the original volume, and then freeze dry it.

3. The anti-allergic composition for reducing the irritation of 4-butylresorcinol and salicylic acid according to claim 1, characterized in that, The preparation of the extract of Scutellaria baicalensis flowers / leaves / stems includes the following steps: 1) Collect the flowers, leaves and stems of Scutellaria baicalensis from the mountains, remove impurities and dry them in the dark at 35-40℃ until the moisture content is <6%, then pulverize them through a 60-80 mesh sieve to obtain Scutellaria baicalensis raw powder; 2) Mix the raw material powder of Scutellaria baicalensis with an aqueous ethanol solution of 60-70% by volume at a material-to-liquid ratio of 1:10-12, and reflux extract at 70-75℃ for 2-3 times, with each extraction time being 1-2 hours. Combine the extracts and concentrate under reduced pressure at 60-65℃ and -0.08--0.09 MPa until there is no alcohol odor. Then purify using AB-8 macroporous adsorption resin. Concentrate the resulting eluent under reduced pressure at 50-55℃ and -0.08--0.09 MPa until it becomes a thick paste without alcohol odor, and then freeze-dry it.

4. The anti-allergic composition for reducing the irritation of 4-butylresorcinol and salicylic acid according to claim 1, characterized in that, The preparation of the grapefruit extract includes the following steps: ① Take fresh pomelo, wash it, separate the peel and pulp, mash the pulp, filter it coarsely with gauze, collect the filtrate and pasteurize it for later use, dry the peel at 40-50℃ until brittle, and crush it through a 40-60 mesh sieve to obtain peel powder. ② Extract the fruit peel powder with a 50-70% ethanol aqueous solution at a material-to-liquid ratio of 1:10-15, reflux at 70-75℃ for 2-3 times, with each extraction lasting 1-2 hours. Combine the extracts and concentrate under reduced pressure at 60-65℃ and -0.08--0.09 MPa until no alcohol odor is detected to obtain a concentrated fruit peel solution. ③ Combine the pasteurized filtrate from step ① and the fruit peel concentrate obtained in step ②, concentrate under reduced pressure at 50-55℃ and -0.08--0.09MPa until it becomes a thick paste, and then freeze-dry it.

5. The anti-allergic composition for reducing the irritation of 4-butylresorcinol and salicylic acid according to claim 1, characterized in that, The polyol solvent is selected from one or more of 1,2-propanediol, 1,3-propanediol, butanediol, 1,2-pentanediol, and 1,2-hexanediol.

6. The anti-allergic composition for reducing the irritation of 4-butylresorcinol and salicylic acid according to claim 1, characterized in that, The phospholipid emulsifier is selected from one or more of lecithin, phosphatidylcholine, sphingomyelin, hydrogenated lecithin, and lysophosphatidylcholine.

7. The anti-allergic composition for reducing the irritation of 4-butylresorcinol and salicylic acid according to claim 1, characterized in that, The nonionic emulsifier is selected from one or more of the following: PEG-20 hydrogenated castor oil, PEG-40 hydrogenated castor oil, polysorbate-20, polysorbate-80, cetearyl alcohol polyether-20, polyglycerol-10 distearate, polyglycerol-10 myristate, and polyglycerol-10 oleate.

8. The anti-allergic composition for reducing the irritation of 4-butylresorcinol and salicylic acid according to claim 1, characterized in that, The moisturizer is selected from one or more of sodium hyaluronate, trehalose, inositol, mannose, and betaine; The antioxidant is selected from one or more of vitamin E, tea polyphenols, ascorbic acid, and rosemary leaf extract.

9. The anti-allergic composition for reducing the irritation of 4-butylresorcinol and salicylic acid according to claim 1, characterized in that, The cyclic polysaccharide is selected from one or more of cyclodextrin, hydroxypropyl cyclodextrin, chitosan, and carrageenan.

10. A method for preparing an anti-allergic composition for reducing the irritation of 4-butylresorcinol and salicylic acid as described in any one of claims 1 to 9, characterized in that, Includes the following steps: S1. Add polyol, phospholipid emulsifier, nonionic emulsifier and antioxidant to the reaction vessel, heat to 70-80℃, and stir evenly at 50-60 rpm; When the temperature is lowered to 50-55℃, 4-butylresorcinol is added, and the mixture is stirred at 40-50 rpm until homogeneous. Then the temperature is lowered to 38-45℃ to obtain the emulsion matrix. S2. The cyclic polysaccharide was dissolved in deionized water at 60℃ and stirred until clear to obtain an aqueous solution of the cyclic polysaccharide; at the same time, salicylic acid was dissolved in ethanol and sonicated to obtain an ethanolic solution of salicylic acid; the ethanolic solution of salicylic acid was added dropwise to the aqueous solution of the cyclic polysaccharide under stirring at 60℃ and 600 rpm, and the reaction was continued for 6 hours; after cooling to room temperature, it was refrigerated at 4℃ and allowed to stand for 12 hours, and the precipitate was collected by suction filtration; the precipitate was washed three times with a pre-cooled ethanol-water mixture at 5℃; the filter cake was vacuum dried at 40℃ for 12 hours to obtain supramolecularly encapsulated salicylic acid; S3. At room temperature, add supramolecularly encapsulated salicylic acid, Prunus persica stem extract, grapefruit extract, Scutellaria baicalensis flower / leaf / stem extract, and humectant to water, stir well, and prepare an aqueous solution. S4. Add the aqueous solution to the emulsion matrix and keep stirring to fully mix the two phases and form a uniform emulsion mixture. Then, process the mixture three times using a high-pressure microjet machine to produce uniform liposomes with a particle size of 10-100 nm. The pressure value is controlled at 10,000-30,000 psi.

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