A cold compress mask for treating acne based on a traditional Chinese medicine compound and a preparation method thereof

Abstract

This invention discloses a cold compress mask for acne treatment based on a traditional Chinese medicine compound and its preparation method, belonging to the field of medical topical Chinese medicine preparations. It solves the problems of existing topical preparations containing irritating ingredients that easily damage the fragile skin barrier and lacking active repair components, thus failing to improve the skin condition of acne patients. The cold compress mask for acne treatment based on a traditional Chinese medicine compound includes anti-acne components, oil-controlling and repairing components, and a carrier matrix. In the embodiments of this invention, the cold compress mask for acne treatment based on a traditional Chinese medicine compound achieves the dual functions of acne treatment and barrier protection through a four-step synergistic mechanism of antibacterial-anti-inflammatory-oil-repair. This results in a mask without irritating ingredients, enhances the skin's barrier function, reduces the damage of external irritants to the skin, and achieves active repair in acne treatment.

Description

Technical Field

[0001] This invention belongs to the field of medical topical preparations of traditional Chinese medicine, specifically relating to a cold compress mask for acne treatment based on a traditional Chinese medicine compound and its preparation method. Background Technology

[0002] Acne, a common skin disease, has always been a hot topic and a challenge in the field of dermatology. Currently, acne treatment methods mainly include drug therapy, physical therapy, and topical preparations. While drug therapy is highly effective, it often comes with a series of side effects, such as gastrointestinal discomfort from oral antibiotics and endocrine disorders caused by hormonal drugs. Physical therapies, such as phototherapy and laser therapy, can quickly improve symptoms, but they are costly and require specialized equipment and personnel, making them inconvenient for daily use by patients. Topical preparations, due to their ease of use and fewer side effects, have become an important means of acne treatment; however, existing topical preparations still have many shortcomings in terms of therapeutic efficacy and safety.

[0003] Chinese patent CN105616232A discloses a method for preparing an anti-inflammatory facial mask made from traditional Chinese medicine, including the following steps: taking 3-8 parts by weight of Phellodendron bark, 8-12 parts by weight of Sophora flavescens root, 8-12 parts by weight of raw rhubarb, 8-12 parts by weight of Houttuynia cordata, 8-12 parts by weight of dandelion, 8-12 parts by weight of licorice root, and 3-8 parts by weight of Gleditsia sinensis, washing and drying them for later use; soaking the above-mentioned medicinal materials in 75% food-grade alcohol at room temperature for 8-10 days, stirring 2-4 times a day; filtering, removing the alcohol by vacuum distillation of the filtrate, compressing and filtering to prepare the mask stock solution; soaking the mask in the mask stock solution to fully moisten it, and then packaging it to obtain the finished product; however, the raw materials of the mask prepared by the above method contain irritating ingredients such as raw rhubarb, which have a keratolytic effect, thereby damaging the patient's fragile skin barrier and aggravating transepidermal water loss. At the same time, the long-term soaking in 75% ethanol during the preparation of the mask can easily destroy heat-sensitive active ingredients such as flavonoids and alkaloids, resulting in a decrease in antibacterial efficacy.

[0004] Chinese patent CN114099623A discloses a dehumidifying and antipruritic ointment and its preparation method. The ointment is prepared from the following medicinal materials in the indicated mass ratios: Atractylodes lancea, Phellodendron chinense, Coptis chinensis, Sophora flavescens, Dictamnus dasycarpus, Stemona japonica, Pseudolarix amabilis, Angelica sinensis, Kochia scoparia, Cnidium monnieri, Zanthoxylum bungeanum, and calcined calamine powder; additional materials include borneol, sesame oil, and white petrolatum. However, in existing antipruritic ointments, the sesame oil contains unsaturated fatty acids, which are easily oxidized and rancid, promoting the growth of Gram-positive bacteria, thus forming a symbiotic relationship with Propionibacterium acnes. Furthermore, these ointments rely solely on the physical encapsulation of petrolatum, lacking active repair components, and therefore cannot improve the skin condition of acne patients.

[0005] Meanwhile, Chinese patent CN112842974A discloses a traditional Chinese medicine acne-removing facial mask powder, which is composed of the following raw materials: rhubarb, sulfur, phellodendron bark, coptis root, scutellaria root, sophora root, dandelion, aloe vera, licorice, and tea tree oil. However, existing facial mask powders rely on mineral drugs such as sulfur as antibacterial ingredients. Although they have a certain antibacterial effect, they are prone to causing adverse reactions such as skin barrier damage and peeling in people with sensitive skin.

[0006] Therefore, in response to the problem that existing topical preparations contain irritating ingredients that can easily damage the fragile skin barrier of patients and lack active repair ingredients, thus failing to improve the skin condition of acne patients, we propose a cold compress mask for acne treatment based on a traditional Chinese medicine compound and its preparation method. Summary of the Invention

[0007] The purpose of this invention is to address the shortcomings of existing technologies by providing a cold compress mask for acne treatment based on a traditional Chinese medicine compound and its preparation method. This invention solves the problems that existing topical preparations contain irritating ingredients that easily damage the patient's fragile skin barrier and lack active repair ingredients, thus failing to improve the skin condition of acne patients.

[0008] This invention is achieved as follows: a cold compress mask for acne treatment based on a traditional Chinese medicine compound. The cold compress mask for acne treatment based on a traditional Chinese medicine compound includes an anti-acne component, an oil-controlling and repairing component, and a carrier matrix. The anti-acne component includes Sophora flavescens, Coptis chinensis, Phellodendron chinense, Scutellaria baicalensis, and Taraxacum mongolicum. The oil-controlling and repairing component includes Atractylodes lancea, Kochia scoparia, and talc.

[0009] Preferably, the acne treatment cold compress mask based on traditional Chinese medicine compound comprises the following raw materials in parts by weight: 2-8 parts Sophora flavescens, 3-8 parts Coptis chinensis, 2-8 parts Phellodendron chinense, 4-9 parts Scutellaria baicalensis, 1-7 parts Taraxacum mongolicum, 2-8 parts Atractylodes lancea, 1-6 parts Kochia scoparia, and 4-12 parts talc.

[0010] Preferably, the acne treatment cold compress mask based on traditional Chinese medicine compound comprises the following raw materials in parts by weight: 5 parts Sophora flavescens, 5 parts Coptis chinensis, 5 parts Phellodendron chinense, 5 parts Scutellaria baicalensis, 5 parts Taraxacum mongolicum, 5 parts Atractylodes lancea, 5 parts Kochia scoparia, and 5 parts talc.

[0011] Preferably, the carrier matrix comprises sodium carboxymethyl cellulose gel, and the pH of the sodium carboxymethyl cellulose gel is 5.5-6.0.

[0012] Preferably, the acne treatment cold compress mask based on traditional Chinese medicine compound adopts a double-layer membrane structure, which is divided into an inner membrane layer and an outer membrane layer.

[0013] Preferably, the inner layer of the membrane is a drug-loaded gel layer, and the outer layer is an isolation-type seaweed fiber membrane.

[0014] On the other hand, the present invention also provides a method for preparing a cold compress mask for acne treatment based on a traditional Chinese medicine compound, the method comprising:

[0015] S10, take the raw materials Sophora flavescens, Coptis chinensis, Phellodendron chinense and Scutellaria baicalensis, crush them to 50-60 mesh using a crusher, then mix them together, add the extract to extract the raw materials stepwise, and obtain the raw material extract. Concentrate the raw material extract to obtain the raw material extract.

[0016] S20, take Atractylodes lancea, Taraxacum mongolicum and Kochia scoparia from the raw materials, add water to Atractylodes lancea, Taraxacum mongolicum and Kochia scoparia and decoct, filter to obtain decoction water extract, concentrate the decoction water extract under reduced pressure to obtain water extract concentrate.

[0017] S30, combine the pre-prepared raw material extract and concentrated aqueous extract, mix the raw material extract and concentrated aqueous extract with talc powder and disperse them in a pre-cooled carrier matrix, homogenize under inert gas protection to obtain a homogeneous gel.

[0018] S40, take the prepared homogeneous gel, use a peristaltic pump to inject the homogeneous gel into the inner mold of the double-layer membrane mold, so that the homogeneous gel fills the drug-loaded gel layer, and use an isolation type seaweed fiber membrane to adsorb and fix the drug-loaded gel layer under vacuum negative pressure to obtain a cold compress mask.

[0019] S50: Transfer the entire cold compress mask to a constant temperature incubator and place it for 10-12 hours. After cutting off the excess gel from the edges, sterilize it with ultraviolet light for 20-25 minutes to obtain the final product.

[0020] Preferably, in step S10, when adding an extractant for stepwise extraction of the raw material, the extractant is ethanol or 1,2-pentanediol.

[0021] Preferably, in step S30, the particle size of the talc powder does not exceed 200 nanometers.

[0022] Compared with the prior art, the embodiments of this application have the following main advantages:

[0023] This invention provides a cold compress mask for acne treatment based on a traditional Chinese medicine compound and its preparation method. The cold compress mask for acne treatment based on the traditional Chinese medicine compound achieves the dual functions of acne treatment and barrier protection through a four-step synergistic mechanism of antibacterial, anti-inflammatory, oil-controlling, and repairing. The ingredients, including Coptis chinensis, Phellodendron chinense, and Taraxacum mongolicum, synergistically inhibit Propionibacterium acnes, resulting in a good antibacterial effect. Meanwhile, Sophora flavescens and Atractylodes lancea effectively downregulate TNF-α inflammatory factors, and Scutellaria baicalensis regulates sebaceous gland activity, reducing excessive sebum secretion. This combination of anti-inflammatory and oil-controlling ingredients not only reduces redness and pain caused by acne but also reduces sebum accumulation. Furthermore, the ingredients, including Kochia scoparia and talc, form a physical protective layer, thereby reducing transepidermal water loss, ensuring the prepared mask contains no irritating ingredients, enhancing the skin's barrier function, reducing the damage of external irritants to the skin, and achieving active repair in acne treatment.

[0024] This invention provides a method for preparing a cold compress mask for acne treatment based on a traditional Chinese medicine compound. The method employs a stepwise extraction process, specifically treating different medicinal materials and fusing them under low-temperature conditions. The talc powder in the raw materials undergoes nano-processing (particle size ≤200nm), which enhances adsorption capacity, reduces the risk of sebum blockage, and strengthens the physical protective layer, thereby reducing transepidermal water loss and preventing high-temperature damage to active ingredients, ensuring the activity of the traditional Chinese medicine components. The resulting cold compress mask has a double-layer membrane structure, which can directly act on the skin, improving drug penetration and therapeutic effect.

[0025] In this embodiment of the invention, the acne treatment cold compress mask based on traditional Chinese medicine compound adopts a double-layer membrane structure. The double-layer membrane structure consists of a drug-loaded gel layer and an isolation seaweed fiber membrane. The drug-loaded gel layer contains active ingredients that can directly act on the skin, thereby improving the drug penetration rate and therapeutic effect. The isolation seaweed fiber membrane can delay water evaporation and extend the mask's action time to 25 minutes, thereby enhancing the cold compress effect of the mask. Attached Figure Description

[0026] Figure 1 This is a schematic diagram showing the test results of the acne-reducing effect of the cold compress masks prepared in Examples 1-5 of this invention.

[0027] Figure 2 This is a schematic diagram showing the safety test results of the cold compress masks prepared in Examples 1-5 of the present invention.

[0028] Figure 3 This is a schematic diagram of the skin barrier repair ability test results of the cold compress masks prepared in Examples 1-5 of this invention. Detailed Implementation

[0029] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs; the terminology used herein in the specification of the application is for the purpose of describing particular embodiments only and is not intended to be limiting of the application; the terms "comprising" and "having," and any variations thereof, in the specification, claims, and foregoing drawings of this application are intended to cover non-exclusive inclusion. The terms "first," "second," etc., in the specification, claims, or foregoing drawings of this application are used to distinguish different objects, not to describe a particular order.

[0030] Example 1

[0031] This invention provides a cold compress mask for acne treatment based on a traditional Chinese medicine compound. The cold compress mask for acne treatment based on a traditional Chinese medicine compound includes an anti-acne component, an oil-controlling and repairing component, and a carrier matrix. The anti-acne component includes Sophora flavescens, Coptis chinensis, Phellodendron chinense, Scutellaria baicalensis, and Taraxacum mongolicum. The oil-controlling and repairing component includes Atractylodes lancea, Kochia scoparia, and talc.

[0032] The acne treatment cold compress mask based on traditional Chinese medicine compound includes the following raw materials in parts by weight: 2 parts Sophora flavescens, 3 parts Coptis chinensis, 2 parts Phellodendron chinense, 4 parts Scutellaria baicalensis, 1 part Taraxacum mongolicum, 2 parts Atractylodes lancea, 1 part Kochia scoparia, and 4 parts talc.

[0033] In this embodiment, the carrier matrix includes sodium carboxymethyl cellulose gel, and the pH of the sodium carboxymethyl cellulose gel is 5.5. The acne treatment cold compress mask based on traditional Chinese medicine compound adopts a double-layer membrane structure, consisting of an inner membrane layer and an outer membrane layer. The inner membrane layer is a drug-loaded gel layer, and the outer membrane layer is an isolation-type seaweed fiber membrane.

[0034] In this embodiment of the invention, the acne treatment cold compress mask based on traditional Chinese medicine compound adopts a double-layer membrane structure. The double-layer membrane structure consists of a drug-loaded gel layer and an isolating seaweed fiber membrane. The drug-loaded gel layer contains active ingredients that can directly act on the skin, thereby improving the drug penetration rate and therapeutic effect. The isolating seaweed fiber membrane can delay water evaporation and extend the mask's action time to 25 minutes, thereby enhancing the cold compress effect of the mask. Using the acne treatment cold compress mask based on traditional Chinese medicine compound of this invention as an adjunct treatment for acne accompanied by skin sensitivity, 2-3 times a week, combined with red and blue light therapy, can improve the efficacy of acne treatment by 28%.

[0035] This invention also provides a method for preparing a cold compress mask for acne treatment based on a traditional Chinese medicine compound, the method comprising:

[0036] S10, take the raw materials Sophora flavescens, Coptis chinensis, Phellodendron chinense and Scutellaria baicalensis, crush them to 50 mesh using a crusher, then mix them together, add the extract to extract the raw materials stepwise, and obtain the raw material extract. Concentrate the raw material extract to obtain the raw material extract, wherein the extract is ethanol.

[0037] S20, take Atractylodes lancea, Taraxacum mongolicum and Kochia scoparia from the raw materials, add water to Atractylodes lancea, Taraxacum mongolicum and Kochia scoparia and decoct, filter to obtain decoction water extract, concentrate the decoction water extract under reduced pressure to obtain water extract concentrate.

[0038] S30, combine the pre-prepared raw material extract and concentrated aqueous extract, mix the raw material extract and concentrated aqueous extract with talc powder and disperse them in a pre-cooled carrier matrix, homogenize under inert gas protection to obtain a homogeneous gel, wherein the particle size of talc powder is 200 nanometers.

[0039] S40, take the prepared homogeneous gel, use a peristaltic pump to inject the homogeneous gel into the inner mold of the double-layer membrane mold, so that the homogeneous gel fills the drug-loaded gel layer, and use an isolation type seaweed fiber membrane to adsorb and fix the drug-loaded gel layer under vacuum negative pressure to obtain a cold compress mask.

[0040] S50: Transfer the entire cold compress mask to a constant temperature incubator and place it for 10 hours. After cutting off the excess gel from the edges, sterilize it with ultraviolet light for 20 minutes to obtain the final product.

[0041] This invention provides a cold compress mask for acne treatment based on a traditional Chinese medicine compound and its preparation method. The cold compress mask for acne treatment based on the traditional Chinese medicine compound achieves the dual functions of acne treatment and barrier protection through a four-step synergistic mechanism of antibacterial, anti-inflammatory, oil-controlling, and repairing. The ingredients, including Coptis chinensis, Phellodendron chinense, and Taraxacum mongolicum, synergistically inhibit Propionibacterium acnes, resulting in a good antibacterial effect. Meanwhile, Sophora flavescens and Atractylodes lancea effectively downregulate TNF-α inflammatory factors, and Scutellaria baicalensis regulates sebaceous gland activity, reducing excessive sebum secretion. This combination of anti-inflammatory and oil-controlling ingredients not only reduces redness and pain caused by acne but also reduces sebum accumulation. Furthermore, the ingredients, including Kochia scoparia and talc, form a physical protective layer, thereby reducing transepidermal water loss, ensuring the prepared mask contains no irritating ingredients, enhancing the skin's barrier function, reducing the damage of external irritants to the skin, and achieving active repair in acne treatment.

[0042] Example 2

[0043] This invention provides a cold compress mask for acne treatment based on a traditional Chinese medicine compound. The cold compress mask for acne treatment based on a traditional Chinese medicine compound includes an anti-acne component, an oil-controlling and repairing component, and a carrier matrix. The anti-acne component includes Sophora flavescens, Coptis chinensis, Phellodendron chinense, Scutellaria baicalensis, and Taraxacum mongolicum. The oil-controlling and repairing component includes Atractylodes lancea, Kochia scoparia, and talc.

[0044] The acne treatment cold compress mask based on traditional Chinese medicine compound comprises the following ingredients in parts by weight: 8 parts Sophora flavescens, 8 parts Coptis chinensis, 8 parts Phellodendron chinense, 9 parts Scutellaria baicalensis, 7 parts Taraxacum mongolicum, 8 parts Atractylodes lancea, 6 parts Kochia scoparia, and 12 parts talc.

[0045] In this embodiment of the invention, the raw material Sophora flavescens can be Sophora flavescens extract. Oxymatrine in Sophora flavescens has a significant anti-inflammatory effect, which can effectively inhibit the expression of inflammatory factors such as IL-8 and reduce redness and pain caused by acne. Coptis chinensis is Coptis chinensis extract. Berberine in Coptis chinensis extract has a strong inhibitory effect on Propionibacterium acnes, which can effectively reduce bacterial reproduction and thus reduce the occurrence of inflammation. At the same time, berberine in Phellodendron chinense can regulate the differentiation and secretion of sebaceous glands, reduce excessive sebum secretion, and thus reduce the formation of acne. The combined use of Coptis chinensis (berberine) and Phellodendron chinense (berberine) in the raw material can reduce the MIC value of Propionibacterium acnes to 0.78 μg / mL, which has a significant synergistic effect compared with the MIC value of Propionibacterium acnes greater than 3.12 μg / mL when used alone.

[0046] It should be noted that the oil-controlling and repairing ingredients include Atractylodes lancea, Kochia scoparia, and talc. Among them, the saponins in Kochia scoparia can enhance the expression of tight junction proteins in keratinocytes, repair the skin barrier, reduce moisture loss, counteract the potential irritation of Sophora flavescens, and enhance the skin's moisturizing ability. Dandelion concentrate is rich in polyphenols such as chlorogenic acid and chicoric acid, which have the dual effects of scavenging free radicals and inhibiting inflammatory pathways.

[0047] In this embodiment, the carrier matrix includes sodium carboxymethyl cellulose gel, and the pH of the sodium carboxymethyl cellulose gel is 6.0. The acne treatment cold compress mask based on traditional Chinese medicine compound adopts a double-layer membrane structure, consisting of an inner membrane layer and an outer membrane layer. The inner membrane layer is a drug-loaded gel layer, and the outer membrane layer is an isolation-type seaweed fiber membrane.

[0048] This invention also provides a method for preparing a cold compress mask for acne treatment based on a traditional Chinese medicine compound, the method comprising:

[0049] S10, take the raw materials Sophora flavescens, Coptis chinensis, Phellodendron chinense and Scutellaria baicalensis, crush them to 60 mesh using a crusher, then mix them together, add the extract to extract the raw materials stepwise, and obtain the raw material extract. Concentrate the raw material extract to obtain the raw material extract, wherein the extract is 1,2-pentanediol;

[0050] S20, take Atractylodes lancea, Taraxacum mongolicum and Kochia scoparia from the raw materials, add water to Atractylodes lancea, Taraxacum mongolicum and Kochia scoparia and decoct, filter to obtain decoction water extract, concentrate the decoction water extract under reduced pressure to obtain water extract concentrate.

[0051] S30, combine the pre-prepared raw material extract and concentrated aqueous extract, mix the raw material extract and concentrated aqueous extract with talc powder and disperse them in a pre-cooled carrier matrix, homogenize under inert gas protection to obtain a homogeneous gel, wherein the particle size of talc powder is 150 nanometers.

[0052] S40, take the prepared homogeneous gel, use a peristaltic pump to inject the homogeneous gel into the inner mold of the double-layer membrane mold, so that the homogeneous gel fills the drug-loaded gel layer, and use an isolation type seaweed fiber membrane to adsorb and fix the drug-loaded gel layer under vacuum negative pressure to obtain a cold compress mask.

[0053] S50: Transfer the entire cold compress mask to a constant temperature incubator and place it for 11 hours. After cutting off the excess gel from the edges, sterilize it with ultraviolet light for 22 minutes to obtain the final product.

[0054] This invention provides a method for preparing a cold compress mask for acne treatment based on a traditional Chinese medicine compound. The method employs a stepwise extraction process, specifically treating different medicinal materials and fusing them under low-temperature conditions. The talc powder in the raw materials undergoes nano-processing (particle size ≤200nm), which enhances adsorption capacity, reduces the risk of sebum blockage, and strengthens the physical protective layer, thereby reducing transepidermal water loss and preventing high-temperature damage to active ingredients, ensuring the activity of the traditional Chinese medicine components. The resulting cold compress mask has a double-layer membrane structure, which can directly act on the skin, improving drug penetration and therapeutic effect.

[0055] Example 3

[0056] This invention provides a cold compress mask for acne treatment based on a traditional Chinese medicine compound. The cold compress mask for acne treatment based on a traditional Chinese medicine compound includes an anti-acne component, an oil-controlling and repairing component, and a carrier matrix. The anti-acne component includes Sophora flavescens, Coptis chinensis, Phellodendron chinense, Scutellaria baicalensis, and Taraxacum mongolicum. The oil-controlling and repairing component includes Atractylodes lancea, Kochia scoparia, and talc.

[0057] The acne treatment cold compress mask based on traditional Chinese medicine compound includes the following raw materials in parts by weight: 3 parts Sophora flavescens, 3 parts Coptis chinensis, 4 parts Phellodendron chinense, 5 parts Scutellaria baicalensis, 2 parts Taraxacum mongolicum, 3 parts Atractylodes lancea, 2 parts Kochia scoparia, and 5 parts talc.

[0058] In this embodiment, the carrier matrix includes sodium carboxymethyl cellulose gel, and the pH of the sodium carboxymethyl cellulose gel is 5.6. The acne treatment cold compress mask based on traditional Chinese medicine compound adopts a double-layer membrane structure, consisting of an inner membrane layer and an outer membrane layer. The inner membrane layer is a drug-loaded gel layer, and the outer membrane layer is an isolation-type seaweed fiber membrane.

[0059] This invention also provides a method for preparing a cold compress mask for acne treatment based on a traditional Chinese medicine compound, the method comprising:

[0060] S10, take the raw materials Sophora flavescens, Coptis chinensis, Phellodendron chinense and Scutellaria baicalensis, crush them to 50 mesh using a crusher, then mix them together, add the extract to extract the raw materials stepwise, and obtain the raw material extract. Concentrate the raw material extract to obtain the raw material extract, wherein the extract is 1,2-pentanediol;

[0061] S20, take Atractylodes lancea, Taraxacum mongolicum and Kochia scoparia from the raw materials, add water to Atractylodes lancea, Taraxacum mongolicum and Kochia scoparia and decoct, filter to obtain decoction water extract, concentrate the decoction water extract under reduced pressure to obtain water extract concentrate.

[0062] S30, combine the pre-prepared raw material extract and concentrated aqueous extract, mix the raw material extract and concentrated aqueous extract with talc powder and disperse them in a pre-cooled carrier matrix, homogenize under inert gas protection to obtain a homogeneous gel, wherein the particle size of talc powder does not exceed 200 nanometers.

[0063] S40, take the prepared homogeneous gel, use a peristaltic pump to inject the homogeneous gel into the inner mold of the double-layer membrane mold, so that the homogeneous gel fills the drug-loaded gel layer, and use an isolation type seaweed fiber membrane to adsorb and fix the drug-loaded gel layer under vacuum negative pressure to obtain a cold compress mask.

[0064] S50: Transfer the entire cold compress mask to a constant temperature incubator and place it for 12 hours. After cutting off the excess gel from the edges, sterilize it with ultraviolet light for 25 minutes to obtain the final product.

[0065] Example 4

[0066] This invention provides a cold compress mask for acne treatment based on a traditional Chinese medicine compound. The cold compress mask for acne treatment based on a traditional Chinese medicine compound includes an anti-acne component, an oil-controlling and repairing component, and a carrier matrix. The anti-acne component includes Sophora flavescens, Coptis chinensis, Phellodendron chinense, Scutellaria baicalensis, and Taraxacum mongolicum. The oil-controlling and repairing component includes Atractylodes lancea, Kochia scoparia, and talc.

[0067] The acne treatment cold compress mask based on traditional Chinese medicine compound includes the following raw materials in parts by weight: 7 parts Sophora flavescens, 6 parts Coptis chinensis, 7 parts Phellodendron chinense, 5 parts Scutellaria baicalensis, 2 parts Taraxacum mongolicum, 7 parts Atractylodes lancea, 5 parts Kochia scoparia, and 10 parts talc.

[0068] In this embodiment, the carrier matrix includes sodium carboxymethyl cellulose gel, and the pH of the sodium carboxymethyl cellulose gel is 6.0. The acne treatment cold compress mask based on traditional Chinese medicine compound adopts a double-layer membrane structure, consisting of an inner membrane layer and an outer membrane layer. The inner membrane layer is a drug-loaded gel layer, and the outer membrane layer is an isolation-type seaweed fiber membrane.

[0069] This invention also provides a method for preparing a cold compress mask for acne treatment based on a traditional Chinese medicine compound, the method comprising:

[0070] S10, take the raw materials Sophora flavescens, Coptis chinensis, Phellodendron chinense and Scutellaria baicalensis, crush them to 60 mesh using a crusher, then mix them together, add the extract to extract the raw materials stepwise, and obtain the raw material extract. Concentrate the raw material extract to obtain the raw material extract, wherein the extract is 1,2-pentanediol;

[0071] S20, take Atractylodes lancea, Taraxacum mongolicum and Kochia scoparia from the raw materials, add water to Atractylodes lancea, Taraxacum mongolicum and Kochia scoparia and decoct, filter to obtain decoction water extract, concentrate the decoction water extract under reduced pressure to obtain water extract concentrate.

[0072] S30, combine the pre-prepared raw material extract and concentrated aqueous extract, mix the raw material extract and concentrated aqueous extract with talc powder and disperse them in a pre-cooled carrier matrix, homogenize under inert gas protection to obtain a homogeneous gel, wherein the particle size of talc powder is 180 nanometers.

[0073] S40, take the prepared homogeneous gel, use a peristaltic pump to inject the homogeneous gel into the inner mold of the double-layer membrane mold, so that the homogeneous gel fills the drug-loaded gel layer, and use an isolation type seaweed fiber membrane to adsorb and fix the drug-loaded gel layer under vacuum negative pressure to obtain a cold compress mask.

[0074] S50: Transfer the entire cold compress mask to a constant temperature incubator and place it for 11 hours. After cutting off the excess gel from the edges, sterilize it with ultraviolet light for 21 minutes to obtain the final product.

[0075] Example 5

[0076] This invention provides a cold compress mask for acne treatment based on a traditional Chinese medicine compound. The cold compress mask for acne treatment based on a traditional Chinese medicine compound includes an anti-acne component, an oil-controlling and repairing component, and a carrier matrix. The anti-acne component includes Sophora flavescens, Coptis chinensis, Phellodendron chinense, Scutellaria baicalensis, and Taraxacum mongolicum. The oil-controlling and repairing component includes Atractylodes lancea, Kochia scoparia, and talc.

[0077] The acne treatment cold compress mask based on traditional Chinese medicine compound includes the following raw materials in parts by weight: 5 parts Sophora flavescens, 5 parts Coptis chinensis, 5 parts Phellodendron chinense, 5 parts Scutellaria baicalensis, 5 parts Taraxacum mongolicum, 5 parts Atractylodes lancea, 5 parts Kochia scoparia, and 5 parts talc.

[0078] In this embodiment, the carrier matrix includes sodium carboxymethyl cellulose gel, and the pH of the sodium carboxymethyl cellulose gel is 5.5. The acne treatment cold compress mask based on traditional Chinese medicine compound adopts a double-layer membrane structure, consisting of an inner membrane layer and an outer membrane layer. The inner membrane layer is a drug-loaded gel layer, and the outer membrane layer is an isolation-type seaweed fiber membrane.

[0079] This invention also provides a method for preparing a cold compress mask for acne treatment based on a traditional Chinese medicine compound, the method comprising:

[0080] S10, take the raw materials Sophora flavescens, Coptis chinensis, Phellodendron chinense and Scutellaria baicalensis, crush them to 50 mesh using a crusher, then mix them together, add the extract to extract the raw materials stepwise, and obtain the raw material extract. Concentrate the raw material extract to obtain the raw material extract, wherein the extract is 1,2-pentanediol;

[0081] S20, take Atractylodes lancea, Taraxacum mongolicum and Kochia scoparia from the raw materials, add water to Atractylodes lancea, Taraxacum mongolicum and Kochia scoparia and decoct, filter to obtain decoction water extract, concentrate the decoction water extract under reduced pressure to obtain water extract concentrate.

[0082] S30, combine the pre-prepared raw material extract and concentrated aqueous extract, mix the raw material extract and concentrated aqueous extract with talc powder and disperse them in a pre-cooled carrier matrix, homogenize under inert gas protection to obtain a homogeneous gel, wherein the particle size of talc powder is 100 nanometers.

[0083] S40, take the prepared homogeneous gel, use a peristaltic pump to inject the homogeneous gel into the inner mold of the double-layer membrane mold, so that the homogeneous gel fills the drug-loaded gel layer, and use an isolation type seaweed fiber membrane to adsorb and fix the drug-loaded gel layer under vacuum negative pressure to obtain a cold compress mask.

[0084] S50: Transfer the entire cold compress mask to a constant temperature incubator and place it for 12 hours. After cutting off the excess gel from the edges, sterilize it with ultraviolet light for 25 minutes to obtain the final product.

[0085] Performance testing:

[0086] To verify the acne-reducing effect, safety (incidence of erythema / sting), and skin barrier repair ability of the cold compress masks prepared in Examples 1-5 of this invention, the cold compress masks prepared in Examples 1-5 of this invention, as well as commercially available product 1 and commercially available product 2, were used to conduct tests on acne-reducing effect (4 weeks), safety (incidence of erythema / sting), and skin barrier repair ability. The test results are shown in Table 1 and... Figure 1-3 As shown.

[0087] Table 1

[0088]

[0089] As shown in Table 1, compared with commercially available products 1 and 2, the cold compress masks prepared in Examples 1-5 of this invention have significantly improved acne reduction effect, safety (incidence of erythema / sting), and skin barrier repair ability. Among them, the acne reduction rate test results show that the product of this invention has a stronger lesion clearance ability for mild to moderate acne vulgaris (mainly papules and pustules), can achieve skin lesion improvement more quickly, and shorten the treatment cycle for patients. The erythema / sting incidence test results show that the active ingredients of the cold compress mask prepared by this invention are pure plant compound, which will not cause damage or irritation to the patient's skin, and the types of active ingredients are relatively few, and the extraction is relatively simple. The skin barrier repair rate test results show that the cold compress mask prepared by this invention has a high skin barrier repair rate after 4 weeks, which is significantly improved compared with commercially available products, reflecting a deep repair effect on skin barrier function.

[0090] In summary, this invention provides a cold compress mask for acne treatment based on a traditional Chinese medicine compound and its preparation method. In this embodiment, the cold compress mask for acne treatment based on the traditional Chinese medicine compound achieves the dual functions of acne treatment and barrier protection through a four-step synergistic mechanism of antibacterial, anti-inflammatory, oil-controlling, and repairing. Furthermore, the raw materials Coptis chinensis, Phellodendron chinense, and Taraxacum mongolicum synergistically inhibit Propionibacterium acnes, resulting in a good antibacterial effect. Simultaneously, Sophora flavescens and Atractylodes lancea effectively downregulate TNF-α inflammatory factors, and Scutellaria baicalensis regulates sebaceous gland activity, reducing excessive sebum secretion. This combination of anti-inflammatory and oil-controlling ingredients not only alleviates redness and pain caused by acne but also reduces sebum accumulation. The raw materials Kochia scoparia combined with talc form a physical protective layer, thereby reducing transepidermal water loss, ensuring the prepared mask contains no irritating ingredients, enhancing the skin's barrier function, reducing the damage of external irritants to the skin, and achieving active repair in acne treatment.

[0091] It should be noted that, for the sake of simplicity, the foregoing embodiments are all described as a series of actions. However, those skilled in the art should understand that the present invention is not limited to the described order of actions, as some steps may be performed in other orders or simultaneously according to the present invention. Furthermore, those skilled in the art should also understand that the embodiments described in the specification are preferred embodiments, and the actions and modules involved are not necessarily essential to the present invention.

[0092] The above embodiments are only used to illustrate the technical solutions of the present invention, and are not intended to limit the scope of protection of the invention. Obviously, the described embodiments are only some embodiments of the present invention, not all embodiments. Based on these embodiments, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention. Although the present invention has been described in detail with reference to the above embodiments, those skilled in the art can still combine, add, delete, or otherwise adjust the features of the various embodiments of the present invention according to the circumstances without conflict or creative effort, thereby obtaining different technical solutions that do not fundamentally depart from the concept of the present invention. These technical solutions also fall within the scope of protection of the present invention.

Claims

1. A cold compress facial mask for acne treatment based on a traditional Chinese medicine compound, characterized in that, The cold compress mask for acne treatment based on traditional Chinese medicine compound includes anti-acne components, oil-controlling and repairing components, and a carrier matrix. The anti-acne components include Sophora flavescens, Coptis chinensis, Phellodendron chinense, Scutellaria baicalensis, and Taraxacum mongolicum. The oil-controlling and repairing components include Atractylodes lancea, Kochia scoparia, and talc. The carrier matrix includes sodium carboxymethyl cellulose gel with a pH of 5.5-6.

0. The cold compress mask for acne treatment based on traditional Chinese medicine compound adopts a double-layer membrane structure, consisting of an inner layer and an outer layer. The inner layer is a drug-loaded gel layer, and the outer layer is an isolating seaweed fiber membrane. The cold compress mask for acne treatment based on traditional Chinese medicine compound includes the following raw materials in parts by weight: 2-8 parts Sophora flavescens, 3-8 parts Coptis chinensis, 2-8 parts Phellodendron chinense, 4-9 parts Scutellaria baicalensis, 1-7 parts Taraxacum mongolicum, 2-8 parts Atractylodes lancea, 1-6 parts Kochia scoparia, and 4-12 parts talc.

2. The cold compress mask for acne treatment based on traditional Chinese medicine compound as described in claim 1, characterized in that: The acne treatment cold compress mask based on traditional Chinese medicine compound includes the following raw materials in parts by weight: 5 parts Sophora flavescens, 5 parts Coptis chinensis, 5 parts Phellodendron chinense, 5 parts Scutellaria baicalensis, 5 parts Taraxacum mongolicum, 5 parts Atractylodes lancea, 5 parts Kochia scoparia, and 5 parts talc.

3. The method for preparing the acne treatment cold compress mask based on a traditional Chinese medicine compound as described in claim 2, characterized in that: The method includes: S10, take the raw materials Sophora flavescens, Coptis chinensis, Phellodendron chinense and Scutellaria baicalensis, crush them to 50-60 mesh using a crusher, then mix them together, add the extract to extract the raw materials stepwise, and obtain the raw material extract. Concentrate the raw material extract to obtain the raw material extract. S20, take Atractylodes lancea, Taraxacum mongolicum and Kochia scoparia from the raw materials, add water to Atractylodes lancea, Taraxacum mongolicum and Kochia scoparia and decoct, filter to obtain decoction water extract, concentrate the decoction water extract under reduced pressure to obtain water extract concentrate. S30, combine the pre-prepared raw material extract and concentrated aqueous extract, mix the raw material extract and concentrated aqueous extract with talc powder and disperse them in a pre-cooled carrier matrix, homogenize under inert gas protection to obtain a homogeneous gel. S40, take the prepared homogeneous gel, use a peristaltic pump to inject the homogeneous gel into the inner mold of the double-layer membrane mold, so that the homogeneous gel fills the drug-loaded gel layer, and use an isolation type seaweed fiber membrane to adsorb and fix the drug-loaded gel layer under vacuum negative pressure to obtain a cold compress mask. S50: Transfer the entire cold compress mask to a constant temperature incubator and place it for 10-12 hours. After cutting off the excess gel from the edges, sterilize it with ultraviolet light for 20-25 minutes to obtain the final product.

4. The method for preparing a cold compress mask for acne treatment based on a traditional Chinese medicine compound as described in claim 3, characterized in that: In step S10, when adding an extractant for stepwise extraction of the raw material, the extractant is ethanol or 1,2-pentanediol.

5. The method for preparing a cold compress mask for acne treatment based on a traditional Chinese medicine compound as described in claim 4, characterized in that: In step S30, the particle size of the talc powder does not exceed 200 nanometers.

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