Water-soluble polysiloxanes, their preparation methods and applications

Abstract

This application relates to water-soluble polysiloxanes, their preparation methods, and applications. The preparation method of water-soluble polysiloxanes includes: mixing lipase, trehalose, and a surfactant to prepare a modified lipase; and mixing vinyl acetate, alkoxysilane, monomethoxy polyethylene glycol, and the modified lipase to prepare the water-soluble polysiloxane. This preparation method utilizes trehalose to coat the lipase, forming a modified lipase that maintains high catalytic activity at higher temperatures for extended periods. This allows for the efficient one-step preparation of water-soluble polysiloxanes via lipase-catalyzed reactions. Compared to traditional acid / base synthesis methods, this method achieves higher conversion rates at lower reaction temperatures, eliminates the need for antioxidants, and yields water-soluble polysiloxanes with good water solubility, light transmittance, and safety.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of daily chemical products, in particular to a water-soluble polysiloxane and a preparation method and application thereof. BACKGROUND

[0002] Water-soluble polysiloxane is a kind of organosilicon polymer in which hydrophilic groups are introduced into polysiloxane to improve its hydrophilicity. Water-soluble polysiloxane has excellent properties of polysiloxane and improved water solubility, and has been widely used in personal care products such as cream, mask, moisturizing water, shaving cream and hand sanitizer.

[0003] At present, water-soluble polysiloxane is usually synthesized by traditional acid / alkali catalysis method, which requires long-time reaction at high temperature (> 80℃). Long-time high-temperature reaction is easy to cause the product to yellow, which affects the appearance of the product, so a small amount of antioxidant (such as BHT or VE, etc.) is usually added to avoid deepening of the color of the system. However, with the continuous development of people's health consciousness, the addition of antioxidants will be considered by some consumers as a potential safety hazard. SUMMARY

[0004] Therefore, it is necessary to provide a preparation method of water-soluble polysiloxane without adding antioxidants, water-soluble polysiloxane and application thereof.

[0005] In a first aspect, the present application provides a preparation method of water-soluble polysiloxane.

[0006] The preparation method of water-soluble polysiloxane comprises the following steps:

[0007] Mixing lipase, trehalose and surfactant to prepare modified lipase;

[0008] Mixing vinyl acetate, alkoxysilane and monomethoxypolyethylene glycol with the modified lipase to prepare water-soluble polysiloxane at 20℃~60℃.

[0009] In some embodiments, the process of preparing the modified lipase comprises:

[0010] Mixing the lipase, the trehalose, the surfactant and the pH buffer at a temperature less than or equal to 45℃ for 1h~3h, and solid-liquid separation to obtain the modified lipase.

[0011] In some embodiments, the pH of the liquid phase is maintained at 7~9 by the pH buffer.

[0012] In some embodiments, the mass ratio of the lipase, the trehalose and the surfactant is 20:(1~10):(1~20); and / or

[0013] The surfactant includes sodium lauroyl sarcosinate; and / or

[0014] The lipase includes lipase CLAB; and / or

[0015] The degree of polymerization of the monomethoxy polyethylene glycol is 6 to 24.

[0016] In some embodiments, the process for preparing the water-soluble polysiloxane includes:

[0017] The vinyl acetate, the alkoxysilane, the monomethoxy polyethylene glycol, the modified lipase, the hydrolysis inhibitor, and the organic solvent are mixed to obtain the first reaction solution;

[0018] The first reaction solution is continuously reacted at a temperature of 35℃~55℃ for 20h~60h to prepare a second reaction solution, and the water-soluble polysiloxane is separated from the second reaction solution.

[0019] In some embodiments, the hydrolysis inhibitor comprises a perfluoropolyether; and / or

[0020] The organic solvent includes one or more of tert-butanol and propylene carbonate.

[0021] In some embodiments, the aqueous phase in the reaction system is continuously separated during the preparation of the second reaction solution.

[0022] In some embodiments, the process of separating the water-soluble polysiloxane from the second reaction solution includes:

[0023] The modified lipase in the second reaction solution was removed by membrane separation, the solution was concentrated by evaporation, and the water-soluble polysiloxane was obtained by chromatographic separation.

[0024] In a second aspect, this application provides a water-soluble polysiloxane.

[0025] A water-soluble polysiloxane is prepared using the above-described method for preparing water-soluble polysiloxanes.

[0026] A third aspect of this application provides the use of a water-soluble polysiloxane in the preparation of cosmetics, wherein the water-soluble polysiloxane includes the above-described water-soluble polysiloxane or a water-soluble polysiloxane prepared by the above-described preparation method.

[0027] The above preparation method utilizes trehalose to coat lipase, forming a modified lipase that maintains high catalytic activity at specific reaction temperatures for an extended period. This effectively overcomes the temperature limitations of lipase catalysis, enabling the efficient one-step preparation of water-soluble polysiloxanes via lipase-catalyzed reactions. Compared to traditional acid / base synthesis methods, this method achieves higher conversion rates at lower reaction temperatures, eliminates the need for antioxidants, and allows for easy separation and removal of the modified lipase. The resulting water-soluble polysiloxanes exhibit good water solubility, light transmittance, and safety. Attached Figure Description

[0028] To more clearly illustrate the technical solutions in the embodiments of this application, the accompanying drawings used in the description of the embodiments will be briefly introduced below. Obviously, the accompanying drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0029] Figure 1 The data are hydrogen nuclear magnetic resonance data of the water-soluble polysiloxane of Example 1 of this application.

[0030] Figure 2 The infrared spectral data are for the water-soluble polysiloxane of Example 1 of this application. Detailed Implementation

[0031] To make the above-mentioned objectives, features, and advantages of this application more apparent and understandable, a detailed description of specific embodiments of this application is provided below. Many specific details are set forth in the following description to provide a thorough understanding of this application. However, this application can be implemented in many other ways different from those described herein, and those skilled in the art can make similar modifications without departing from the spirit of this application. Therefore, this application is not limited to the specific embodiments disclosed below.

[0032] In the description of this application, "multiple" means at least two, such as two, three, etc., unless otherwise explicitly specified. In this application, "at least one" means one or more, such as one, two, or more than two. "Multiple" or "several" means at least two, such as two, three, etc.

[0033] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the application. The term "and / or" as used herein includes any and all combinations of one or more of the associated listed items.

[0034] When a numerical range is disclosed herein, the range is considered continuous and includes the minimum and maximum values ​​of the range, as well as every value between the minimum and maximum values. Furthermore, when the range refers to integers, it includes every integer between the minimum and maximum values ​​of the range. Additionally, when multiple ranges are provided to describe a feature or characteristic, the ranges may be combined. In other words, unless otherwise specified, all ranges disclosed herein should be understood to include any and all subranges to which they are incorporated.

[0035] Unless otherwise specified, all steps in this application may be performed sequentially or randomly. For example, the method includes steps (a) and (b), indicating that the method may include steps (a) and (b) performed sequentially, or it may include steps (b) and (a) performed sequentially. For example, the method may also include step (c), indicating that step (c) may be added to the method in any order. For example, the method may include steps (a), (b), and (c), or it may include steps (a), (c), and (b), or it may include steps (c), (a), and (b), etc.

[0036] In this application, "above" or "below" includes the number itself. For example, "below 1" includes 1.

[0037] Unless otherwise specified, the temperature parameters in this application are permitted to be either constant-temperature treatment or variations within a certain temperature range. It should be understood that the constant-temperature treatment allows temperature fluctuations within the precision range of the instrument control, such as ±5℃, ±4℃, ±3℃, ±2℃, or ±1℃.

[0038] The first aspect of this application provides a method for preparing high-purity, light-colored water-soluble polysiloxanes without the need to add antioxidants.

[0039] For example, a method for preparing water-soluble polysiloxanes includes the following steps:

[0040] Modified lipase was prepared by mixing lipase, trehalose and surfactant.

[0041] Water-soluble polysiloxanes were prepared by mixing vinyl acetate, alkoxysilane, monomethoxy polyethylene glycol, and modified lipase at 20℃~60℃.

[0042] In the above preparation method, to address the problem that lipase catalytic activity is greatly affected by temperature and is easily deactivated during long-term reactions, trehalose is used to coat the lipase to form a modified lipase. The trehalose coating allows the modified lipase to maintain high catalytic activity for extended periods at higher temperatures. This enables the efficient one-step preparation of water-soluble polysiloxanes via lipase-catalyzed reactions at specific temperatures. Compared to traditional acid / base synthesis methods, the above method for preparing water-soluble polysiloxanes achieves higher conversion rates at lower reaction temperatures, eliminates the need for antioxidants, and yields water-soluble polysiloxanes with good water solubility, light transmittance, and safety.

[0043] In some embodiments, the molar ratio of monomethoxy polyethylene glycol to vinyl acetate is 1:(0.9~1.1). Optionally, the molar ratio of monomethoxy polyethylene glycol to vinyl acetate can be, but is not limited to, other values ​​within the range of 1:0.8, 1:0.9, 1:1, 1:1.1, 1:1.2, or 1:(0.8~1.2).

[0044] In some embodiments, alkoxysilanes include dimethyldiethoxysilane.

[0045] In some embodiments, the molar ratio of dimethyldiethoxysilane to monomethoxy polyethylene glycol is 1:(2~2.6). Optionally, the molar ratio of dimethyldiethoxysilane to monomethoxy polyethylene glycol can be, but is not limited to, other values ​​within the range of 1:2, 1:2.1, 1:2.2, 1:2.3, 1:2.4, 1:2.5, 1:2.6, or 1:(2~2.6).

[0046] In this application, the mechanism of the synthetic reaction is as follows: Monomethoxy polyethylene glycol reacts with vinyl acetate under the directed catalysis of lipase. After the ester bond of vinyl acetate is broken, the acetyl group combines with the hydroxyl group of monomethoxy polyethylene glycol to generate monomethoxy polyethylene glycol acetate, and acetaldehyde is generated simultaneously. The chemical equation for this process is as follows:

[0047] mPEG-OH + CH3COOCH=CH2→ mPEG-OCOCH3+ CH3CHO;

[0048] Furthermore, the ester group of monomethoxy polyethylene glycol acetate undergoes an exchange reaction with the silicon-oxygen bond of alkoxysilane, completing the grafting of polyethylene glycol. Taking dialkoxydimethylsilane as an example, the chemical equation is as follows:

[0049] (CH3)2Si(OR')2 + mPEG-OCOCH3→(CH3)2Si(OR')[(O-mPEG)] + CH3COOR';

[0050] (CH3)2Si(OR')[(O-mPEG)] + mPEG-OCOCH3 → (CH3)2Si(O-mPEG)2 + CH3COOR'.

[0051] When preparing water-soluble polysiloxanes via the above reaction, the pH of the reaction system is recommended to be controlled between 7.0 and 8.5. In some embodiments, vinyl acetate, alkoxysilane, monomethoxy polyethylene glycol, modified lipase, and pH buffer are mixed to prepare water-soluble polysiloxanes under conditions of pH 7-8.5 and 20°C-60°C.

[0052] In some embodiments, the temperature for preparing the modified lipase does not exceed 45°C. Further, the temperature for preparing the modified lipase is 20°C to 40°C to reduce lipase inactivation.

[0053] In some embodiments, the process of preparing the modified lipase includes:

[0054] Lipase, trehalose, surfactant and pH buffer are mixed at a temperature not exceeding 45°C for 1 to 3 hours, and then separated into solid and liquid components to obtain modified lipase.

[0055] In some embodiments, the pH of the liquid phase is controlled to be 7-9 using a pH buffer. It is understood that the liquid phase refers to the liquid phase of the mixture formed by the lipase, trehalose, surfactant, and pH buffer. Optionally, the pH of the liquid phase can be, but is not limited to, 7, 7.1, 7.2, 7.3, 7.4, 5.5, 7.7, 7.8, 7.9, 8.0, 8.1, 8.2, 8.3, 8.4, 8.5, 8.6, 8.7, 8.8, 8.9, 9.0, or other values ​​within the range of 7-9. Maintaining pH stability of the reaction system using a pH buffer helps the lipase maintain high catalytic activity. Further, the pH of the liquid phase is controlled to be 7.5-9 using a pH buffer.

[0056] In some embodiments, the mass ratio of lipase, trehalose, and surfactant is 1:0.2:0.5.

[0057] In some of these implementations, the pH buffer includes a Tris-HCl buffer.

[0058] In some embodiments, the surfactant includes sodium lauroyl sarcosinate.

[0059] In some of these embodiments, the lipase includes lipase CLAB.

[0060] In some embodiments, the degree of polymerization of monomethoxy polyethylene glycol is 6 to 24. The degree of polymerization of polyethylene glycol in monomethoxy polyethylene glycol has a significant impact on hydrophilicity; maintaining the above-mentioned degree of polymerization yields water-soluble polysiloxanes with appropriate hydrophilicity.

[0061] In some embodiments, the process for preparing water-soluble polysiloxanes includes:

[0062] Water-soluble polysiloxanes were prepared by reacting vinyl acetate, alkoxysilane, monomethoxy polyethylene glycol, and modified lipase at 20°C to 60°C in the presence of hydrolysis inhibitors and organic solvents.

[0063] Furthermore, to obtain a higher yield, the process for preparing water-soluble polysiloxanes includes: mixing vinyl acetate, alkoxysilane, monomethoxy polyethylene glycol, modified lipase, hydrolysis inhibitor, and organic solvent to obtain a first reaction solution; continuously reacting the first reaction solution at a temperature of 35℃~55℃ for 20h~60h to prepare a second reaction solution; and separating the water-soluble polysiloxane from the second reaction solution.

[0064] In some embodiments, the hydrolysis inhibitor includes perfluoropolyether. The addition of perfluoropolyether can effectively inhibit the hydrolysis of silanes and improve reaction efficiency.

[0065] In some embodiments, the organic solvent includes one or more of tert-butanol and propylene carbonate.

[0066] In some embodiments, the volume ratio of tert-butanol, propylene carbonate, and perfluoropolyether is (15-40):(2-5):1. Maintaining this solvent ratio helps to improve the yield of the target product.

[0067] In some embodiments, the aqueous phase in the reaction system is continuously separated during the preparation of the second reaction solution. Continuous separation of the aqueous phase helps to suppress hydrolysis and improve reaction conversion. Optionally, a molecular sieve column is used to separate the aqueous phase.

[0068] In some embodiments, the process of separating the water-soluble polysiloxane from the second reaction solution includes:

[0069] The modified lipase was removed by membrane separation, concentrated by evaporation, and then separated by chromatography to obtain water-soluble polysiloxane.

[0070] In some embodiments, the crude reaction product is evaporated and concentrated, and then separated and purified using a rapid chromatographic purification system.

[0071] In some embodiments, the stationary phase of the chromatographic column comprises 200-300 mesh silica gel.

[0072] In some embodiments, a gradient elution method is used to elute the crude product, with the mobile phase comprising dichloromethane and methanol, and the ratio of dichloromethane to methanol being gradually reduced.

[0073] In some embodiments, the elution flow rate is 30 mL / min to 50 mL / min.

[0074] In some implementations, the detection wavelength is set to 210 nm.

[0075] In some implementations, an automatic fraction collector is used to collect fractions according to the peak time.

[0076] In some embodiments, the fractions of the target product are compared by thin-layer chromatography (developing solvent DCM / MeOH=9 / 1, Rf value approximately 0.4-0.5) to combine the fractions.

[0077] In some embodiments, the solvent in the combined distillates is evaporated to obtain a water-soluble polysiloxane.

[0078] In a second aspect, this application provides a water-soluble polysiloxane.

[0079] A water-soluble polysiloxane is prepared using the above-described method for preparing water-soluble polysiloxanes.

[0080] A third aspect of this application provides the use of a water-soluble polysiloxane in the preparation of cosmetics, wherein the water-soluble polysiloxane includes the above-described water-soluble polysiloxane or a water-soluble polysiloxane prepared by the above-described preparation method.

[0081] In some of these implementations, cosmetics include face creams, conditioners, and shampoos.

[0082] The present application will be further described in detail below with reference to specific embodiments.

[0083] Unless otherwise specified, the raw materials used in the following specific embodiments and comparative examples are all commercially available products; the instruments used are all commercially available products; and the processes used are all conventionally selected by those skilled in the art unless otherwise specified.

[0084] Example 1

[0085] This embodiment provides a water-soluble polysiloxane.

[0086] The preparation method of water-soluble polysiloxane is as follows:

[0087] 10g of lipase Novozym 435, 2g of trehalose, and 5g of sodium lauroyl sarcosinate were dissolved in 50mL of Tris-HCl buffer at pH 6.8, and the mixture was sonicated at 40℃ for 2h. The mixture was then ultrafiltered and lyophilized to obtain the modified lipase.

[0088] The components are mixed to obtain a first reaction solution. The raw materials for the first reaction solution are:

[0089] 12.1g of vinyl acetate;

[0090] 7.2g of dimethyldiethoxysilane;

[0091] mPEG-18-OH 100g;

[0092] Modified lipase 4.8g;

[0093] 10 mL of perfluoropolyether (Krytox);

[0094] 150 mL of tert-butanol; and

[0095] 40 mL of propylene carbonate.

[0096] The first reaction solution was continuously reacted at 50°C in a nitrogen atmosphere for 40 hours to prepare the second reaction solution. During the reaction, a 3Å molecular sieve column was used to circulate and remove water, keeping the water content less than 100ppm.

[0097] The modified lipase in the second reaction solution was removed using a 0.45 μm filter membrane, followed by evaporation and concentration. The solution was then separated by column chromatography to obtain water-soluble polysiloxanes. The specific separation method is as follows:

[0098] The crude reaction product after evaporation and concentration was separated and purified using a rapid chromatographic purification system.

[0099] The stationary phase was 300-mesh silica gel, and the mobile phase (eluent) was dichloromethane (DCM) and methanol (MeOH). Gradient elution was used at a flow rate of 40 mL / min. The initial DCM / MeOH ratio was 95 / 5 (v / v), and the final ratio was 85 / 15 (v / v).

[0100] The detection wavelength was set to 210nm.

[0101] Use an automatic fraction collector to collect fractions according to the peak time.

[0102] By comparing the fractions containing the target product with an Rf value of approximately 0.4-0.5 using thin-layer chromatography (developing solvent DCM / MeOH=9 / 1), the fractions were combined.

[0103] The combined fractions were subjected to rotary evaporation under reduced pressure at 35°C to remove the solvent, finally yielding 98.1g of colorless, transparent, oily, water-soluble polysiloxane, with a product yield of 95.3%.

[0104] Please see Figure 1 , 2 , Figure 1 The data for the hydrogen nuclear magnetic resonance of the water-soluble polysiloxane in this embodiment shows signal peaks corresponding to the hydrogen of the mPEG-18-OH ethoxy group and the hydrogen of the Si-CH3 methyl group. Figure 2 The infrared spectral data for the water-soluble polysiloxane in this embodiment are shown at 800 cm⁻¹. -1 The area exhibited characteristic peaks of siloxanes, and the above characterization spectrum indicates that the grafting reaction proceeded smoothly.

[0105] Example 2

[0106] This embodiment provides a water-soluble polysiloxane.

[0107] The preparation method of the water-soluble polysiloxane in this embodiment is basically the same as that in Example 1, except that mPEG-18-OH is replaced with mPEG-24-OH, and the first reaction solution is continuously reacted at 40°C in a nitrogen atmosphere for 50 hours to prepare the second reaction solution. The final product yield is 94.2%.

[0108] Example 3

[0109] This embodiment provides a water-soluble siloxane.

[0110] The preparation method of the water-soluble siloxane in this embodiment is basically the same as that in Example 1, except that:

[0111] In the preparation of the modified lipase, the mass ratio of lipase, trehalose, and sodium lauroyl sarcosinate was 1:0.05:0.3. The final product yield was 92.5%.

[0112] Example 4

[0113] This embodiment provides a water-soluble siloxane.

[0114] The preparation method of the water-soluble siloxane in this embodiment is basically the same as that in Example 1, except that:

[0115] The first reaction solution did not contain the hydrolysis inhibitor Krytox perfluoropolyether, and the solvent was only 190 mL of tert-butanol. The final product yield was 82.1%.

[0116] Comparative Example 1

[0117] This comparative example provides a water-soluble siloxane.

[0118] The preparation method of the water-soluble polysiloxane in this comparative example is basically the same as that in Example 1, except that Novozym 435 lipase is used instead of the modified lipase.

[0119] Comparative Example 2

[0120] This comparative example provides a water-soluble siloxane.

[0121] The preparation method of the water-soluble siloxane in this comparative example is basically the same as that in comparative example 1, except that the first reaction solution is continuously reacted at 45°C in a nitrogen atmosphere for 40 hours to prepare the second reaction solution.

[0122] Comparative Example 3

[0123] This comparative example provides a water-soluble siloxane.

[0124] The preparation method of the water-soluble siloxane in this comparative example is basically the same as that in comparative example 1, except that the first reaction solution is continuously reacted at 40°C in a nitrogen atmosphere for 40 hours to prepare the second reaction solution.

[0125] Comparative Example 4

[0126] This comparative example provides a water-soluble siloxane.

[0127] The water-soluble siloxanes in this comparative example were prepared using a traditional acid-catalyzed method:

[0128] 100 g of mPEG-18-OH was mixed with 7.2 g of dimethyldiethoxysilane, and 0.5 g of p-toluenesulfonic acid was added as a catalyst. The mixture was reacted at 110 °C under nitrogen protection for 24 h. After the reaction was completed, the mixture was neutralized with sodium bicarbonate, filtered, and the filtrate was distilled under reduced pressure to remove volatiles, yielding a pale yellow viscous liquid. The product yield was 85.0%.

[0129] Test case

[0130] The water solubility, aqueous solution odor, color (APHA), and stability of the water-soluble polysiloxanes in the examples and comparative examples were tested, and the test results are shown in Tables 1 and 2. The water solubility test method was to compare the transmittance of a 10 wt% aqueous solution of water-soluble polysiloxane at 420 nm.

[0131] Table 1. Basic performance test data of water-soluble polysiloxanes in the examples and comparative examples.

[0132]

[0133] Table 2. Stability test data of water-soluble polysiloxanes in the examples and comparative examples.

[0134]

[0135] As can be seen from the above comparison, water-soluble polysiloxanes synthesized by the traditional acid-base synthesis method without the addition of antioxidants have a yellowish color, while the water-soluble polysiloxanes prepared by the preparation method of this application have a significantly lighter color and also have the characteristics of high yield and high stability.

[0136] The technical features of the above embodiments can be combined in any way. For the sake of brevity, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0137] The embodiments described above are merely illustrative of several implementation methods of this application, and while the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the invention patent. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of this application, and these all fall within the protection scope of this application. Therefore, the protection scope of this invention patent should be determined by the appended claims, and the specification can be used to interpret the content of the claims.

Claims

1. A method for preparing a hydrophilically modified silane, characterized in that, The method comprises the following steps: mixing a lipase, trehalose and a surfactant to prepare a modified lipase; mixing a vinyl acetate, an alkoxysilane and a monomethoxypolyethylene glycol with the modified lipase to prepare a hydrophilic modified silane at 20-60°C.

2. The method for preparing hydrophilic modified silane according to claim 1, characterized in that, The process for preparing the modified lipase comprises: mixing the lipase, the trehalose, the surfactant and a pH buffer at a temperature of less than or equal to 45°C for 1-3 hours, and then solid-liquid separation to obtain the modified lipase.

3. The method for preparing hydrophilic modified silane according to claim 2, characterized in that, The pH of the liquid phase is maintained at 7-9 by the pH buffer.

4. The method for preparing hydrophilic modified silane according to claim 1, characterized in that, The mass ratio of the lipase, the trehalose and the surfactant is 20:(1-10):(1-20); and / or The surfactant comprises sodium lauroyl sarcosinate; and / or The lipase comprises lipase CLAB; and / or The monomethoxypolyethylene glycol has a degree of polymerization of 6-24.

5. The method of claim 1 to 4, wherein The process for preparing the hydrophilic modified silane comprises: mixing the vinyl acetate, the alkoxysilane, the monomethoxypolyethylene glycol, the modified lipase, a hydrolysis inhibitor and an organic solvent to obtain a first reaction liquid; allowing the first reaction liquid to react at a temperature of 35-55°C for 20-60 hours to prepare a second reaction liquid, and separating the hydrophilic modified silane from the second reaction liquid.

6. The method for preparing hydrophilic modified silane according to claim 5, characterized in that, The hydrolysis inhibitor comprises perfluoropolyether; and / or The organic solvent comprises one or more of tert-butyl alcohol and propylene carbonate.

7. The method for preparing hydrophilic modified silane according to claim 5, characterized in that, During the preparation of the second reaction liquid, the aqueous phase in the reaction system is continuously separated.

8. The method for preparing hydrophilic modified silane according to claim 5, characterized in that, The process for separating the hydrophilic modified silane from the second reaction liquid comprises: removing the modified lipase in the second reaction liquid by membrane separation, evaporating and concentrating, and then separating the hydrophilic modified silane by chromatography.

9. A hydrophilically modified silane characterized by, The hydrophilic modified silane is prepared by the method of any one of claims 1-8.

10. Use of a hydrophilic modified silane in the preparation of a cosmetic product, wherein the hydrophilic modified silane comprises or is prepared by the method of any one of claims 1-8 or the hydrophilic modified silane of claim 9.

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