Toothpaste for preventing and treating oral ulcer and preparation method thereof

Abstract

The invention belongs to the technical field of oral care, and provides toothpaste for preventing and treating oral ulcer and a preparation method thereof, and the toothpaste for preventing and treating oral ulcer comprises the following components: dipotassium glycyrrhizinate, beta-glucan, sodium hyaluronate, a honeysuckle extract, poloxamer 407, an abrasive, a humectant, a foaming agent, an adhesive, a sweetening agent, a preservative, essence and water. The core of the toothpaste is that a gel film is formed in an oral cavity by utilizing the temperature-sensitive characteristic of poloxamer 407, so that the retention and action time of active ingredients is remarkably prolonged, and long-acting nursing is realized; meanwhile, a sodium lauroyl sarcosinate SLS-free mild foaming system is adopted, so that mucous membrane stimulation is avoided. The formula can effectively prevent oral ulcer recurrence through multi-mechanism synergy of anti-inflammation, immunoregulation and physical repair, and clinically shows that the recurrence rate can be reduced by 55%, the recurrence interval can be prolonged to 28 days or above, the tooth brushing pricking occurrence rate is reduced to 5%, and use is safe and comfortable.

Description

Technical Field

[0001] This invention relates to the field of oral care technology, and in particular to a toothpaste for preventing and treating oral ulcers and its preparation method. Background Technology

[0002] Recurrent aphthous ulcers (RAU) are the most common ulcerative lesions of the oral mucosa, affecting approximately 10% to 25% of the population. Their main clinical features include recurrent attacks, significant burning pain, and slow healing, severely impacting patients' eating, speech, and quality of life.

[0003] Currently, commercially available toothpaste products primarily focus on cleaning, cavity prevention, and whitening teeth, and their formulations generally lack targeted maintenance for oral mucosal health. More concerning is that many traditional toothpastes use sodium lauryl sulfate (SLS) as a foaming agent. Studies have shown that SLS may have potential irritant and exfoliating effects on the mucosa, potentially inducing or worsening oral ulcers.

[0004] In addition, the active ingredients in regular toothpaste (such as anti-inflammatory and repairing ingredients) are quickly rinsed away after brushing, and their retention time on the oral mucosa is extremely short, making it difficult to form effective protection and exert a sustained repairing effect. This is a significant technical shortcoming for ulcer-prone people who require long-term care.

[0005] In the prior art, CN110123669A discloses a mouthwash containing licorice extract for relieving oral discomfort, but its dosage form determines that the ingredient has a short retention time and does not solve the irritation problem in toothpaste. CN112220727A discloses an oral care composition containing sodium hyaluronate, but does not involve achieving long-term drug delivery through thermosensitive gel technology.

[0006] Therefore, there is an urgent need in this field for a toothpaste specifically designed for people susceptible to ulcers that can not only avoid mucosal irritation, but also extend the duration of action of active ingredients through technological innovation, thereby achieving long-lasting and proactive prevention and care. Summary of the Invention

[0007] The purpose of this invention is to provide a toothpaste for preventing and treating oral ulcers and its preparation method. This toothpaste, by introducing temperature-sensitive gel technology and compounding multiple active ingredients, achieves multiple effects such as long-lasting retention care, anti-inflammatory soothing, immune regulation and physical barrier repair, and can effectively prevent ulcer recurrence and help improve the oral environment.

[0008] To achieve the above-mentioned objectives, the present invention provides the following technical solution: This invention provides a toothpaste for preventing and treating oral ulcers, comprising the following ingredients by weight percentage: dipotassium glycyrrhizate 0.1-0.5%, β-glucan 0.05-0.3%, sodium hyaluronate 0.02-0.1%, honeysuckle extract 0.1-0.8%, poloxamer 407 0.5-3.0%, abrasive 15-50%, humectant 20-50%, foaming agent 0.5-2.5%, binder 0.5-2.0%, sweetener 0.1-3.0%, preservative 0.05-0.5%, and fragrance 0.5-1.5%, with the balance being water.

[0009] Preferably, the weight percentage of poloxamer 407 is 1.0 to 2.0%.

[0010] Preferably, the friction agent is one or more of hydrated silica, dicalcium phosphate, and calcium carbonate; The moisturizer is one or more of glycerin and sorbitol; The foaming agent is one or more of sodium lauroyl sarcosinate and potassium cocoamide propionate; The adhesive is one or more of sodium carboxymethyl cellulose, xanthan gum, and carrageenan; The sweetener is one or more of xylitol, sucralose and sodium saccharin; The preservative is one or more of sodium benzoate, potassium sorbate, and methylparaben.

[0011] Preferably, the toothpaste contains the following ingredients in weight percentage: dipotassium glycyrrhizate 0.2%, β-glucan 0.1%, sodium hyaluronate 0.05%, honeysuckle extract 0.3%, poloxamer 407 1.5%, hydrated silica 20%, glycerin 22%, sorbitol 13%, sodium lauroyl sarcosinate 1.0%, sodium carboxymethyl cellulose 1.0%, xanthan gum 0.2%, xylitol 1.0%, sucralose 0.08%, sodium benzoate 0.2%, and fragrance 1.0%, with the balance being water.

[0012] The present invention also provides a method for preparing the toothpaste, comprising the following steps: (1) At 300~500 rpm, mix most of the humectant, binder and some water, adjust the speed to 800~1200 rpm, stir for 30~50 min to form paste 1; (2) Adjust the stirring speed to 400~600 rpm, add the abrasive to paste 1, and homogenize at 1100~1500 rpm for 10~20 min to obtain paste 2; (3) Under the condition of 400~600rpm, β-glucan, sodium hyaluronate, dipotassium glycyrrhizate and honeysuckle extract were added to paste 2 in sequence and mixed to obtain paste 3; (4) Add poloxamer 407 to paste 3 and mix to obtain paste 4; (5) Add foaming agent to paste 4 and stir at 400-600 rpm for 10-15 min to obtain paste 5; (6) Add sweetener, preservative and flavoring to paste 5, and stir at 400~600rpm for 15~20min to obtain paste 6; (7) Vacuum degassing of paste 6 yields the final toothpaste.

[0013] Preferably, step (3) further includes a step of premixing the β-glucan with a portion of water into a slurry before adding it to paste 2; and the sodium hyaluronate further includes a step of pre-dispersing it with a portion of glycerin before adding it to paste 2. The sweetener and preservative described in step (6) are further dissolved using the remaining water before being added to paste 5; The vacuum degree of vacuum degassing in step (7) is -0.095MPa to -0.098MPa, and the vacuum degassing time is 10 to 15 minutes.

[0014] The beneficial effects of this invention are as follows: 1. Innovative Long-Lasting Care Mechanism: The core technology lies in utilizing the thermosensitive properties of poloxamer 407, overcoming the key technical bottleneck of short retention time of active ingredients in traditional toothpaste. This ingredient is easy to process at room temperature and reversibly forms a transparent gel protective film at oral temperature (approximately 37°C). This film significantly prolongs the retention and action time of active ingredients such as dipotassium glycyrrhizate (anti-inflammatory) and honeysuckle extract (heat-clearing and antibacterial) in ulcer-prone areas, achieving a technological leap from "instant contact during brushing" to "continuous care after brushing."

[0015] 2. Multi-target synergistic prevention and repair: A synergistic system of "anti-inflammatory-immune regulation-physical repair" has been constructed. Dipotassium glycyrrhizate rapidly reduces inflammation and relieves discomfort; β-glucan enhances the mucosal resistance through immune regulation, reducing the risk of recurrence; sodium hyaluronate forms a hydrophilic and moisturizing film on the mucosal surface, isolating external stimuli and promoting tissue repair. These three components work synergistically with temperature-sensitive gel technology to maintain mucosal health from different levels.

[0016] 3. Gentle and safe from the root cause: It completely abandons SLS foaming agent, which may induce ulcers, and chooses sodium lauroyl sarcosinate, a gentler alternative, to minimize mucosal damage caused by formula irritation. Experiments have shown that the incidence of brushing pain is as low as 5%, making it especially suitable for people with sensitive mucosa.

[0017] 4. Significant preventative effects and superior user experience: Clinical observations show that continuous use for 3 months can reduce the ulcer recurrence rate by 55%, and extend the average recurrence interval to more than 28 days. Multiple moisturizing agents ensure a smooth and delicate texture, providing a comfortable user experience and encouraging long-term adherence for sustained preventative effects. Detailed Implementation

[0018] This invention provides a toothpaste for preventing and treating oral ulcers, comprising the following ingredients by weight percentage: dipotassium glycyrrhizate 0.1-0.5%, β-glucan 0.05-0.3%, sodium hyaluronate 0.02-0.1%, honeysuckle extract 0.1-0.8%, poloxamer 407 0.5-3.0%, abrasive 15-50%, humectant 20-50%, foaming agent 0.5-2.5%, binder 0.5-2.0%, sweetener 0.1-3.0%, preservative 0.05-0.5%, and fragrance 0.5-1.5%, with the balance being water.

[0019] In this invention, the weight percentage of poloxamer 407 is preferably 1.0 to 2.0%, and more preferably 1.5%.

[0020] In this invention, the friction agent is preferably one or more of hydrated silica, dicalcium phosphate and calcium carbonate, and more preferably hydrated silica; The moisturizer is preferably one or more of glycerin and sorbitol, and more preferably glycerin and sorbitol; The foaming agent is preferably one or more of sodium lauroyl sarcosinate and potassium cocoamide propionate, and more preferably sodium lauroyl sarcosinate. The adhesive is preferably one or more of sodium carboxymethyl cellulose, xanthan gum and carrageenan, and more preferably sodium carboxymethyl cellulose and xanthan gum. The sweetener is preferably one or more of xylitol, sucralose and sodium saccharin, and more preferably xylitol and sucralose; The preservative is preferably one or more of sodium benzoate, potassium sorbate and methylparaben, and more preferably sodium benzoate.

[0021] In this invention, the toothpaste preferably contains the following ingredients in weight percentage: dipotassium glycyrrhizate 0.2%, β-glucan 0.1%, sodium hyaluronate 0.05%, honeysuckle extract 0.3%, poloxamer 407 1.5%, hydrated silica 20%, glycerin 22%, sorbitol 13%, sodium lauroyl sarcosinate 1.0%, sodium carboxymethyl cellulose 1.0%, xanthan gum 0.2%, xylitol 1.0%, sucralose 0.08%, sodium benzoate 0.2%, and fragrance 1.0%, with the balance being water.

[0022] The present invention also provides a method for preparing the toothpaste, preferably comprising the following steps: (1) At 300~500 rpm, mix most of the humectant, binder and some water, adjust the speed to 800~1200 rpm, stir for 30~50 min to form paste 1; (2) Adjust the stirring speed to 400~600 rpm, add the abrasive to paste 1, and homogenize at 1100~1500 rpm for 10~20 min to obtain paste 2; (3) Under the condition of 400~600rpm, β-glucan, sodium hyaluronate, dipotassium glycyrrhizate and honeysuckle extract were added to paste 2 in sequence and mixed to obtain paste 3; (4) Add poloxamer 407 to paste 3 and mix to obtain paste 4; (5) Add foaming agent to paste 4 and stir at 400-600 rpm for 10-15 min to obtain paste 5; (6) Add sweetener, preservative and flavoring to paste 5, and stir at 400~600rpm for 15~20min to obtain paste 6; (7) Vacuum degassing of paste 6 yields the final toothpaste.

[0023] In this invention, the method for preparing the toothpaste preferably includes the following steps: (1) At 400 rpm, most of the moisturizer, binder and some water are mixed, the speed is adjusted to 1000 rpm and stirred for 40 min to form paste 1; (2) Adjust the stirring speed to 500 rpm, add the abrasive to paste 1, and homogenize at 1300 rpm for 15 min to obtain paste 2; (3) At 500 rpm, β-glucan, sodium hyaluronate, dipotassium glycyrrhizate and honeysuckle extract were added to paste 2 in sequence and mixed to obtain paste 3; (4) Add poloxamer 407 to paste 3 and mix to obtain paste 4; (5) Add foaming agent to paste 4 and stir at 500 rpm for 12 min to obtain paste 5; (6) Add sweetener, preservative and flavoring to paste 5 and stir at 500 rpm for 18 min to obtain paste 6; (7) Vacuum degassing of paste 6 yields the final toothpaste.

[0024] In this invention, step (3) of the β-glucan is further included in the step of premixing a portion of water and β-glucan into a slurry before being added to paste 2; the sodium hyaluronate is further included in the step of pre-dispersing a portion of glycerin before being added to paste 2; The sweetener and preservative described in step (6) are further dissolved using the remaining water before being added to paste 5; The vacuum degree of vacuum degassing in step (7) is preferably -0.095MPa to -0.098MPa, and more preferably -0.096MPa. The vacuum degassing time is preferably 10 to 15 minutes, and more preferably 12 minutes.

[0025] The technical solutions provided by the present invention will be described in detail below with reference to the embodiments, but they should not be construed as limiting the scope of protection of the present invention.

[0026] Example 1

[0027] 1. A toothpaste for preventing and treating oral ulcers, formulated per 100 kg according to the following weight percentages: Dipotassium glycyrrhizate: 0.2%; β-glucan: 0.1%; Sodium hyaluronate: 0.05%; Honeysuckle extract: 0.3%; Poloxamer 407: 1.5%; Hydrated silica (abrasive): 20%; Glycerin (humectant): 22%; Sorbitol (humectant): 13%; Sodium lauroyl sarcosinate (foaming agent): 1.0%; Sodium carboxymethyl cellulose (binder): 1.0%; Xanthan gum (binder): 0.2%; Xylitol (sweetener): 1.0%; Sucralose (sweetener): 0.08%; Sodium benzoate (preservative): 0.2%; Fragrance: 1.0%; and Deionized water: balance.

[0028] 2. The toothpaste is prepared as follows: (1) Preparation of glue phase: Add 20 kg (91% of the total amount) of glycerin, sorbitol and 60% of the total water volume of deionized water to the paste preparation pot, start stirring (400 rpm), slowly and evenly add sodium carboxymethyl cellulose and xanthan gum, after the addition is complete, increase the stirring speed to 1000 rpm and stir for 40 minutes to form a transparent and uniform paste 1.

[0029] (2) Powder dispersion: Adjust the stirring speed to 500 rpm, add hydrated silica to paste 1, and after the addition is complete, homogenize at high speed (1300 rpm) for 15 minutes to ensure that the system is uniform and free of dry powder particles, and obtain paste 2.

[0030] (3) Addition of active ingredients: Keep stirring at 500 rpm, premix β-glucan with 40% deionized water to form a slurry and then add it; Add sodium hyaluronate after pre-dispersing it in 2 kg of glycerin, and homogenize for 5 minutes; Then add dipotassium glycyrrhizate and stir for 10 minutes until completely dispersed and dissolved; Add honeysuckle extract and stir for 10 minutes until completely dispersed and dissolved to obtain paste 3.

[0031] (4) Add gelling and foaming agents: Add poloxamer 407 and stir until completely dissolved to obtain paste 4; add sodium lauroyl sarcosinate and stir at 500 rpm for 12 minutes until uniform to obtain paste 5.

[0032] (5) Adding ingredients: Dissolve xylitol, sucralose and sodium benzoate in the remaining deionized water and add them to paste 5; then add fragrance and stir at 500 rpm for 18 minutes to mix them thoroughly and evenly to obtain paste 6.

[0033] (6) Vacuum degassing and pH adjustment: Turn on the vacuum system (vacuum degree -0.096 MPa), and perform high-speed homogenization degassing for 12 minutes to obtain paste 7.

[0034] (7) Dispensing and filling: Dispense the paste 7 under vacuum, fill and seal it to obtain the final finished toothpaste.

[0035] Example 2 (Low Concentration Example)

[0036] 1. A toothpaste for preventing and treating oral ulcers, formulated per 100 kg according to the following weight percentages: Dipotassium glycyrrhizate: 0.1%, β-glucan: 0.05%, sodium hyaluronate: 0.02%, honeysuckle extract: 0.1%, poloxamer 407: 0.5%, hydrated silica: 15%, glycerin: 15%, sorbitol: 15%, sodium lauroyl sarcosinate: 0.5%, sodium carboxymethyl cellulose: 0.9%, xanthan gum: 0.1%, xylitol: 0.5%, sucralose: 0.05%, sodium benzoate: 0.1%, fragrance: 0.8%, and deionized water: balance.

[0037] 2. The preparation method is the same as in Example 1.

[0038] Example 3 (High Concentration Example)

[0039] 1. A toothpaste for preventing and treating oral ulcers, formulated per 100 kg according to the following weight percentages: Dipotassium glycyrrhizate: 0.5%, β-glucan: 0.3%, sodium hyaluronate: 0.1%, honeysuckle extract: 0.8%, poloxamer 407: 3.0%, hydrated silica: 25%, glycerin: 25%, sorbitol: 15%, sodium lauroyl sarcosinate: 1.5%, sodium carboxymethyl cellulose: 1.5%, xanthan gum: 0.4%, xylitol: 2.0%, sucralose: 0.15%, sodium benzoate: 0.3%, fragrance: 1.2%, and deionized water: balance.

[0040] 2. The preparation method is the same as in Example 1.

[0041] Comparative Example 1 (Commercially Available Products)

[0042] A common toothpaste has the following formula: 20% hydrated silica, 25% glycerin, 10% sorbitol, 1.5% sodium lauryl sulfate (SLS), 1.2% sodium carboxymethyl cellulose, 1.0% fragrance, 0.2% sodium saccharin, 0.2% sodium benzoate, and the balance being deionized water; pH 7.0.

[0043] Comparative Example 2 (Missing Items in this Invention)

[0044] A toothpaste that does not contain poloxamer 407 has the same ingredients and proportions as in Example 1, except that it does not contain poloxamer 407, and is supplemented with deionized water.

[0045] Experimental Example: Evaluation of Ulcer Prevention Efficacy

[0046] To verify the efficacy of the toothpaste of this invention, 60 patients with recurrent oral ulcers were recruited and randomly divided into three groups (n=20). Each group used toothpaste from Example 1, Comparative Example 1 (containing SLS), or Comparative Example 2 (without poloxamer 407), respectively, brushing twice daily for three consecutive months. The results are shown in the table below: Table 1 Comparison of ulcer prevention efficacy and user experience

[0047] Conclusion: The toothpaste of Example 1 was significantly superior to the two comparative examples in preventing ulcer recurrence, prolonging the recurrence interval, and reducing brushing sting. This fully demonstrates the core role of the poloxamer 407 thermosensitive gel technology in achieving long-lasting care, and the importance of the SLS-free gentle foaming system in ensuring safe use. This specific combination produced an unexpected synergistic technical effect.

[0048] As can be seen from the above embodiments and experimental examples, the toothpaste of the present invention can effectively reduce the recurrence frequency of oral ulcers, significantly prolong the recurrence interval, and is extremely gentle and non-irritating during use, providing an effective daily prevention and care solution for patients with recurrent oral ulcers.

[0049] As can be seen from the above embodiments, the present invention provides a toothpaste for preventing and treating oral ulcers and its preparation method. The toothpaste for preventing and treating oral ulcers comprises the following components: dipotassium glycyrrhizate, β-glucan, sodium hyaluronate, honeysuckle extract, poloxamer 407, abrasive, humectant, foaming agent, binder, sweetener, preservative, fragrance, and water. The core of the toothpaste of the present invention lies in utilizing the thermosensitive properties of poloxamer 407 to form a gel film in the oral cavity, significantly prolonging the retention and action time of active ingredients, and achieving long-lasting care; at the same time, it adopts a sodium lauroyl sarcosinate sodium SLS-free mild foaming system to avoid mucosal irritation. This formula can effectively prevent the recurrence of oral ulcers through the synergistic effect of anti-inflammatory, immunomodulatory, and physical repair mechanisms. Clinical studies show that continuous use for 3 months can reduce the recurrence rate by 55%, prolong the recurrence interval to more than 28 days, and the incidence of brushing stinging sensation is as low as 5%, making it safe and comfortable to use.

[0050] The above description is only a preferred embodiment of the present invention. It should be noted that for those skilled in the art, several improvements and modifications can be made without departing from the principle of the present invention, and these improvements and modifications should also be considered within the scope of protection of the present invention.

Claims

1. A toothpaste for preventing and treating oral ulcers, characterized in that, It contains the following ingredients by weight percentage: dipotassium glycyrrhizate 0.1-0.5%, β-glucan 0.05-0.3%, sodium hyaluronate 0.02-0.1%, honeysuckle extract 0.1-0.8%, poloxamer 407 0.5-3.0%, abrasive 15-50%, humectant 20-50%, foaming agent 0.5-2.5%, binder 0.5-2.0%, sweetener 0.1-3.0%, preservative 0.05-0.5%, and fragrance 0.5-1.5%, with the balance being water.

2. The toothpaste according to claim 1, characterized in that, The weight percentage of poloxamer 407 is 1.0 to 2.0%.

3. The toothpaste according to claim 1, characterized in that, The friction agent is one or more of hydrated silica, dicalcium phosphate and calcium carbonate; The moisturizer is one or more of glycerin and sorbitol; The foaming agent is one or more of sodium lauroyl sarcosinate and potassium cocoamide propionate; The adhesive is one or more of sodium carboxymethyl cellulose, xanthan gum, and carrageenan; The sweetener is one or more of xylitol, sucralose and sodium saccharin; The preservative is one or more of sodium benzoate, potassium sorbate, and methylparaben.

4. The toothpaste according to claim 1, characterized in that, The toothpaste contains the following ingredients by weight percentage: dipotassium glycyrrhizate 0.2%, β-glucan 0.1%, sodium hyaluronate 0.05%, honeysuckle extract 0.3%, poloxamer 407 1.5%, hydrated silica 20%, glycerin 22%, sorbitol 13%, sodium lauroyl sarcosinate 1.0%, sodium carboxymethyl cellulose 1.0%, xanthan gum 0.2%, xylitol 1.0%, sucralose 0.08%, sodium benzoate 0.2%, and fragrance 1.0%, with the balance being water.

5. The method for preparing the toothpaste according to any one of claims 1 to 4, characterized in that, Includes the following steps: (1) At 300~500 rpm, mix most of the humectant, binder and some water, adjust the speed to 800~1200 rpm, stir for 30~50 min to form paste 1; (2) Adjust the stirring speed to 400~600 rpm, add the abrasive to paste 1, and homogenize at 1100~1500 rpm for 10~20 min to obtain paste 2; (3) Under the condition of 400~600rpm, β-glucan, sodium hyaluronate, dipotassium glycyrrhizate and honeysuckle extract were added to paste 2 in sequence and mixed to obtain paste 3; (4) Add poloxamer 407 to paste 3 and mix to obtain paste 4; (5) Add foaming agent to paste 4 and stir at 400-600 rpm for 10-15 min to obtain paste 5; (6) Add sweetener, preservative and flavoring to paste 5, and stir at 400~600rpm for 15~20min to obtain paste 6; (7) Vacuum degassing of paste 6 yields the final toothpaste.

6. The preparation method according to claim 5, characterized in that, Step (3) The β-glucan is added to paste 2 by premixing it with some water to form a slurry; the sodium hyaluronate is added to paste 2 by pre-dispersing it with some glycerin. The sweetener and preservative described in step (6) are further dissolved using the remaining water before being added to paste 5; The vacuum degree of vacuum degassing in step (7) is -0.095MPa to -0.098MPa, and the vacuum degassing time is 10 to 15 minutes.

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