Oral composition

Abstract

The technical problem to be solved by the present invention is that in an oral composition, if a condensed phosphate for preventing dental calculus deposition and an astringent for imparting astringent feeling are used in combination, it is possible that oral mucosa dissection occurs. In view of the above situation, it is desirable that the oral composition can exhibit a sense of astringency and prevent the exfoliation of the oral mucosa. In order to solve the technical problem, the present invention provides an oral composition containing (A) sodium fluoride, (B) a water-soluble calcium salt, (C) one or more substances selected from condensed phosphoric acid and alkali metal salts thereof, and (D) an astringent.

Description

TECHNICAL FIELD

[0001] The present application relates to an oral composition. BACKGROUND

[0002] In a tooth in which a root surface is exposed, calculus is easily deposited, and a biofilm of periodontal pathogenic bacteria is formed as the calculus is deposited, and thus periodontal disease is easily developed. Therefore, in an oral composition for the purpose of preventing the deposition of calculus, condensed phosphoric acid such as pyrophosphoric acid, polyphosphoric acid, or the like is incorporated.

[0003] Further, in order to impart a tightening feeling (astringent feeling) to the oral cavity after the use of the oral composition, a compound having astringency (an astringent) is incorporated in the oral composition. The oral composition can exhibit an astringent feeling of the oral cavity by containing the astringent, and the prevention of periodontal disease is actually felt.

[0004] For example, Patent Documents 1 and 2 disclose an oral composition containing an astringent.

[0005] PRIOR ART DOCUMENTS PATENT DOCUMENTS Patent Document 1: Japanese Patent Application Laid-Open No. 11-21219 Patent Document 2: Japanese Patent Application Laid-Open No. 2015-205836 SUMMARY PROBLEMS TO BE SOLVED BY THE INVENTION However, if condensed phosphates and astringents are used in combination, peeling of the oral mucosa can occur.

[0006] Therefore, an object of the present application is to provide an oral composition which can prevent the deposition of calculus, exhibit an astringent feeling, and prevent peeling of the oral mucosa.

[0007] MEANS FOR SOLVING THE PROBLEMS The present application has the following modes.

[0008] <1> An oral composition comprising: (A) sodium fluoride; (B) a water-soluble calcium salt; (C) one or more selected from condensed phosphoric acid and alkali metal salts thereof; and (D) an astringent.

[0009] <2> The oral composition according to <1>, wherein the component (D) is at least one selected from allantoin and derivatives thereof, the molar ratio of the component (C) / the component (D) is 0.03 to 14.00.

[0010] <3> The oral composition according to <1>, wherein the (D) component is at least one selected from azulenes and derivatives thereof and water-soluble copper compounds, The molar ratio of the (C) component / the (D) component is 1.00 to 3000.

[0011] <4> The oral composition according to <1>, wherein the (D) component is sodium chloride, The molar ratio of the (C) component / the (D) component is 0.0004 to 0.26.

[0012] <5> The oral composition according to any one of <1> to <4>, wherein the molar ratio of the (B) component / the (A) component is 0.03 to 10.

[0013] <6> The oral composition according to any one of <1> to <5>, wherein the molar ratio of the (C) component / the (A) component is 0.005 to 1.5.

[0014] <7> The oral composition according to any one of <1> to <6>, wherein the oral composition is a dentifrice.

[0015] Effects of the Invention The oral composition according to the present application can prevent deposition of dental calculus, give astringency, and prevent peeling of oral mucosa. DETAILED DESCRIPTION

[0016] In the present specification, the "oral composition" means a composition mainly for use in the oral cavity.

[0017] In the present specification, the "water-soluble" means solubility in water at 20°C of 1 g / 100 g or more.

[0018] In the present specification, the "~" indicating a numerical range means that the lower limit value and the upper limit value recited before and after it are included.

[0019] [Oral Composition] The oral composition of the present application contains an (A) component, a (B) component, a (C) component, and a (D) component.

[0020] < (A) Component > (A) component is sodium fluoride (NaF). The oral composition, by using the (A) component and the (B) component in combination, can prevent peeling of the oral mucosa. As the (A) component, commercially available products can be used.

[0021] < (B) component > The (B) component is a water-soluble calcium salt. The oral composition, by using the (A) component and the (B) component in combination, can prevent peeling of the oral mucosa.

[0022] As the (B) component, for example, calcium chloride, calcium nitrate, calcium acetate, calcium citrate, calcium glycerophosphate, calcium gluconate, calcium benzoate, calcium formate, calcium fumarate, calcium lactate, calcium butyrate, calcium isobutyrate, calcium malate, calcium maleate, calcium propionate, calcium valerate, calcium pantothenate, and the like can be given. As the (B) component, calcium chloride, calcium glycerophosphate, calcium gluconate, calcium lactate, and calcium pantothenate are preferred.

[0023] The (B) component can be one alone or a combination of two or more. As the (B) component, commercially available products can be used.

[0024] < (C) component > The (C) component is at least one selected from condensed phosphoric acid and alkali metal salts thereof. The (C) component can be combined with two or more. The oral composition, by containing the (C) component, can prevent deposition of dental calculus. In addition, by using the (A) to (C) components in combination, the effect of the (D) component on the oral mucosa can be mitigated.

[0025] As the condensed phosphoric acid or the alkali metal salt thereof, water-soluble condensed phosphoric acid or the salt thereof can be preferably used.

[0026] As the condensed phosphoric acid, for example, straight-chain polyphosphoric acid, cyclic polyphosphoric acid can be given.

[0027] As the straight-chain polyphosphoric acid, for example, pyrophosphoric acid, tripolyphosphoric acid, tetrapolyphosphoric acid, and the like can be given.

[0028] As the cyclic polyphosphoric acid, for example, trimetaphosphoric acid, tetrametaphosphoric acid, hexametaphosphoric acid, and the like can be given.

[0029] As the alkali metal salt, sodium salt, potassium salt, and the like can be given.

[0030] Among them, as the (C) component, pyrophosphate, tripolyphosphate, hexametaphosphate are preferred, and pyrophosphate is more preferred, and potassium pyrophosphate, sodium pyrophosphate are further preferred.

[0031] These (C) components can be one alone or a combination of two or more.

[0032] As the (C) component, commercially available products can be used.

[0033] < (D) component > (D) Component is an astringent. The oral composition imparts an astringent sensation to the oral cavity after the oral composition is used by containing the (D) component. The astringent sensation of the oral cavity is typically a tight sensation of the gingiva.

[0034] As the (D) component, for example, allantoin or a derivative thereof, azulene or a derivative thereof, sodium chloride, a water-soluble copper compound, and the like can be given. That is, as the (D) component, one or more selected from the group consisting of allantoin and a derivative thereof, azulene and a derivative thereof, sodium chloride, and a water-soluble copper compound can be used.

[0035] As the allantoin or a derivative thereof, for example, allantoin, allantoin chlorohydrex aluminum, allantoin aluminum, dihydroxy allantoin aluminum, and the like can be given.

[0036] As the azulene or a derivative thereof, for example, azulene, sodium azulene sulfonate hydrate, and the like can be given.

[0037] As the water-soluble copper compound, for example, sodium copper chlorophyllin, copper sulfate, copper chloride, and the like can be given.

[0038] Among the above (D) components, allantoin, sodium azulene sulfonate hydrate, and sodium copper chlorophyllin are preferred.

[0039] As the (D) component, commercially available products can be used.

[0040] <Content of Each Component> The content of the (A) component is preferably 0.09 to 1.3% by mass, more preferably 0.10 to 1.1% by mass, relative to the total mass of the oral composition. When the content of the (A) component is equal to or more than the above lower limit value, a complex with the (C) component can be stably formed, and thus the peeling of the oral mucosa can be more favorably prevented. When the content of the (A) component is equal to or less than the above upper limit value, a complex with the (C) component can be stably formed, and thus the peeling of the oral mucosa can be more favorably prevented.

[0041] The content of the (B) component is preferably 0.02 to 5.0% by mass, more preferably 0.03 to 3.0% by mass, relative to the total mass of the oral composition. When the content of the (B) component is equal to or more than the above lower limit value, a complex with the (C) component can be stably formed, and thus the peeling of the oral mucosa can be more favorably prevented. When the content of the (B) component is equal to or less than the above upper limit value, a complex with the (C) component can be stably formed, and thus the peeling of the oral mucosa can be more favorably prevented.

[0042] The content of the (C) component is preferably 0.02 to 3.0% by mass, more preferably 0.03 to 1.3% by mass, relative to the total mass of the oral composition. When the content of the (C) component is equal to or more than the above lower limit value, the deposition of dental calculus can be more favorably prevented. When the content of the (C) component is equal to or less than the above upper limit value, the peeling of the oral mucosa can be more favorably prevented.

[0043] The content of the (D) component can be appropriately determined in consideration of the kind of the (D) component, for example, in the range of 0.001 to 10% by mass relative to the total mass of the oral composition.

[0044] In the case where the (D) component is at least one selected from the group consisting of allantoin and derivatives thereof, the content of the (D) component is preferably 0.01 to 0.5% by mass, more preferably 0.1 to 0.5% by mass, relative to the total mass of the oral composition.

[0045] In the case where the (D) component is at least one selected from the group consisting of azulene and derivatives thereof and water-soluble copper compounds, the content of the (D) component is preferably 0.001 to 0.15% by mass, more preferably 0.005 to 0.15% by mass, relative to the total mass of the oral composition.

[0046] In the case where the (D) component is sodium chloride, the content of the (D) component is preferably 2.0 to 10.0% by mass, more preferably 5.0 to 10.0% by mass, relative to the total mass of the oral composition.

[0047] When the content of the (D) component is equal to or more than the lower limit value described above, the sense of convergence can be further improved. When the content of the (D) component is equal to or less than the upper limit value described above, peeling of the oral mucosa can be more effectively prevented, and the flavor can be prevented from being reduced.

[0048] The molar ratio of the (B) component to the (A) component (B / A ratio) is preferably 0.03 to 10.0, more preferably 0.08 to 2.0. When the B / A ratio is within the range described above, peeling of the oral mucosa can be more effectively prevented.

[0049] The molar ratio of the (C) component to the (A) component (C / A ratio) is preferably 0.005 to 1.5, more preferably 0.01 to 1.3. When the C / A ratio is within the range described above, deposition of dental calculus can be more effectively prevented.

[0050] In the case where the (D) component is at least one selected from the group consisting of allantoin and derivatives thereof, the molar ratio of the (C) component to the (D) component (C / D ratio) is preferably 0.03 to 14.00, more preferably 0.04 to 4.00.

[0051] In the case where the (D) component is at least one selected from the group consisting of azulene and derivatives thereof and water-soluble copper compounds, the C / D ratio is preferably 1.00 to 3000, more preferably 1.45 to 250.

[0052] When component (D) is sodium chloride, the C / D ratio is preferably 0.0004 to 0.26, more preferably 0.0005 to 0.046.

[0053] When the C / D ratio is above the lower limit mentioned above, the astringency can be further enhanced. When the C / D ratio is below the upper limit mentioned above, it can better prevent the peeling of the oral mucosa and prevent the reduction of aroma.

[0054] <Water> Oral compositions typically also contain water. Examples of water include purified water, sterile purified water, and water for injection.

[0055] The water content in oral compositions can be appropriately set according to the product form and method of use of the oral composition.

[0056] For example, when the oral composition is toothpaste, the water content relative to the total mass of the oral composition is preferably 5 to 90% by mass, more preferably 10 to 60% by mass, and even more preferably 20 to 50% by mass.

[0057] <Other Ingredients> Oral compositions may further contain other ingredients besides (A), (B), (C), (D) and water.

[0058] Other ingredients can be appropriately selected from known ingredients, taking into account the form and method of application of the oral composition. Examples of other ingredients include surfactants, abrasives, binders, thickeners, colorants, sweeteners, preservatives, flavorings, active ingredients, and pH adjusters.

[0059] As surfactants, surfactants known in oral compositions can be used. Examples include nonionic surfactants, amphoteric surfactants, and anionic surfactants.

[0060] Examples of nonionic surfactants include polyoxyethylene alkyl ethers, polyoxyethylene hydrogenated castor oil, sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters (e.g., polyoxyethylene sorbitan monostearate), alkylolamides, polyoxyethylene fatty acid esters, polyoxyethylene alkenyl ethers, glycerol fatty acid esters, sucrose fatty acid esters (e.g., maltose fatty acid esters), sugar alcohol fatty acid esters (e.g., maltitol fatty acid esters, lactitol fatty acid esters), fatty acid diethanolamides (e.g., lauric acid mono- or diethanolamides), polyoxyethylene polyoxypropylene copolymers, polyoxyethylene polyoxypropylene fatty acid esters, polyoxyethylene polyoxypropylene (EOPO) copolymers, alkyl glucosides, and polyglycerol fatty acid esters.

[0061] The number of carbon atoms in the alkyl group of the polyoxyethylene alkyl ether is usually 12 to 18, preferably 14 to 18 (e.g., lauryl, stearyl), and the average number of moles of ethylene oxide added is usually 5 to 30, preferably 15 to 30.

[0062] The average number of ethylene oxide addition moles in polyoxyethylene hydrogenated castor oil is typically 5 to 100 moles, preferably 20 to 100 moles, and more preferably 20 to 60 moles.

[0063] The fatty acids in sorbitan fatty acid esters typically have 12 to 18 carbon atoms. Polyoxyethylene sorbitan fatty acid esters typically have 16 to 18 carbon atoms in their fatty acids, and the average molar addition of ethylene oxide is typically 10 to 40 moles.

[0064] The alkyl chain of alkylolamides typically has 12 to 14 carbon atoms.

[0065] The polyoxyethylene-polyoxypropylene (EOPO) copolymer is preferably composed of an average addition molar number of ethylene oxide of 20 to 210 and an average addition molar number of propylene oxide of 15 to 60. It can be a block copolymer or a random copolymer.

[0066] Examples of amphoteric surfactants include betaine-type and amino acid-type amphoteric surfactants. Examples of betaine-type amphoteric surfactants include fatty acid amamidopropyl betaine (e.g., cocamidopropyl betaine), alkyl acetate betaine (e.g., lauryl dimethylaminoacetic acid betaine and other alkylaminoacetic acid betaines), and alkyl imidazoline betaine (e.g., alkyl carboxymethyl hydroxyethyl imidazoline betaine). Fatty acid amamidopropyl betaine and alkyl acetate betaine are preferred, and cocamidopropyl betaine is more preferred. When the amphoteric surfactant has alkyl or acyl groups, they can be either straight-chain or branched, and either saturated or unsaturated. The number of carbon atoms in the alkyl or acyl group is preferably 10 to 20, more preferably 12 to 18, and even more preferably 14 to 16.

[0067] Examples of anionic surfactants include alkyl sulfates (e.g., sodium dodecyl sulfate (SDS)), α-olefin sulfonates (AOS), lauroyl methyl taurine (LMT), sulfosuccinic acid, GluNa, and alanine salts. The alkyl or acyl group can be either straight-chain or branched, and either saturated or unsaturated. The number of carbon atoms in the alkyl or acyl group is preferably, for example, 10 to 20, more preferably 12 to 18, and even more preferably 14 to 16.

[0068] The salt can be selected from pharmacologically permissible salts. Examples of pharmacologically permissible salts include base addition salts and amino acid salts. Examples of salts include inorganic base salts such as sodium salts, potassium salts, calcium salts, magnesium salts, and ammonium salts; organic base salts such as triethylammonium salts, triethanolamine salts, pyridinium salts, and diisopropylammonium salts; and basic amino acid salts such as arginine salts. Among these, inorganic base salts are preferred, alkali metal salts (e.g., sodium salts, potassium salts) or ammonium salts are more preferred, and sodium salts are even more preferred.

[0069] When the oral composition contains a surfactant, the surfactant content is preferably 0.05 to 10% by mass relative to the total mass of the oral composition, more preferably 0.1 to 8.0% by mass.

[0070] Examples of abrasives include anhydrous silica, precipitated silica, silica gel, aluminosilicate, zirconium silicate, and other silica-based abrasives; dicalcium phosphate dihydrate or anhydrous dicalcium phosphate, monocalcium phosphate, tricalcium phosphate, tetracalcium phosphate, calcium carbonate, calcium hydroxide, aluminum hydroxide, insoluble sodium metaphosphate, trimagnesium phosphate, and magnesium carbonate. Silica-based abrasives are preferred.

[0071] The content of the abrasive relative to the total mass of the oral composition is preferably 0 to 60% by mass, more preferably 0 to 30% by mass, and may also be 25% by mass or less. A content of 0% by mass indicates that the abrasive is not present.

[0072] Examples of adhesives include: organic adhesives selected from water-soluble polymers such as sodium carboxymethyl cellulose, methyl cellulose, hydroxymethyl cellulose, hydroxyethyl cellulose, and other cellulose derivatives; gums such as xanthan gum, astragalus gum, ebony gum, and gum arabic; polyacrylates such as sodium polyacrylate; and inorganic adhesives such as thickening silica, thickening aluminum silica, Veegum, and diatomite.

[0073] The content of the adhesive relative to the total mass of the oral composition is preferably 0.05 to 13.0% by mass, for example.

[0074] When the adhesive contains an organic adhesive, the amount of the organic adhesive relative to the total mass of the oral composition is more preferably 0.1 to 3% by mass, and more preferably 0.5 to 2.5% by mass.

[0075] When the adhesive contains an inorganic adhesive, considering the adsorption of fluoride ions on the tooth surface, the content of the inorganic adhesive relative to the total mass of the oral composition is more preferably 0 to 10.0% by mass, and even more preferably 0 to 8.0% by mass.

[0076] Examples of thickeners include sugar alcohols such as sorbitol, xylitol, erythritol, and maltitol, as well as polyols such as glycerol, propylene glycol, and polyethylene glycol with an average molecular weight of 160 to 400 (the average molecular weight recorded in the Japanese Standard for Quasi-Pharmaceutical Raw Materials 2006).

[0077] When the oral composition contains a thickener, the content of the thickener relative to the total mass of the oral composition is preferably 15% by mass or more, more preferably 20% by mass or more. The upper limit of the content of the thickener is preferably 70% by mass or less, more preferably 65% ​​by mass or less.

[0078] Examples of colorants include Red No. 2, Red No. 3, Red No. 225, Red No. 226, Yellow No. 4, Yellow No. 5, Yellow No. 205, Blue No. 1, Blue No. 2, Blue No. 201, Blue No. 204, Green No. 3, Mica Titanium, and Titanium Oxide.

[0079] Examples of sweeteners include sodium saccharin, aspartame, steviol glycosides, stevia extract, p-methoxycinnamonaldehyde, neohesperidin dihydrochalcone, and perilla stigma.

[0080] Examples of preservatives include methylparaben, ethylparaben, butylparaben, and other paraben esters, as well as benzoic acid or its salts such as sodium benzoate.

[0081] As spices, for example, the following can be cited: peppermint oil, spearmint oil, anise oil, eucalyptus oil, wintergreen oil, cinnamon oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, mint oil (Japanese: Hacka oil), cardamom oil, coriander oil, orange peel oil, lime oil, lavender oil, rosemary oil, bay oil, chamomile oil, caraway oil, marjoram oil, elemi oil, lemongrass oil, oregano oil, pine needle oil, neroli oil, rose oil, jasmine oil, grapefruit oil, sweetie oil, yuzu oil, iris concrete, peppermint absolute, rose absolute, neroli, etc. natural spices; spices obtained after processing these natural spices (removing the fore fraction, removing the after fraction, fractional distillation, liquid-liquid extraction, essentialization, powder-spice formation, etc.); menthol, carvone, anethole, eucalyptol, methyl salicylate, cinnamaldehyde, eugenol, 3-L-menthoxy-1,2-propanediol, thymol, linalool, linalyl acetate, limonene, menthone, menthyl acetate, N-substituted-p-menthane-3-carboxamide, pinene, octanal, citral, pulegone, carvyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allyl cyclohexanepropionate, methyl anthranilate, ethyl methylphenylglycidate, vanillin, undecanoic acid lactone, hexanal, butanol, isoamyl alcohol, hexenol, dimethyl sulfide, methylcyclopentenolone, furfural, trimethylpyrazine, ethyl lactate, ethyl thioacetate, etc. single-component spices; strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, fruit mixed flavor, tropical fruit flavor, etc. blended flavors, and spice raw materials known to be used in oral compositions can be used in combination.

[0082] The content of the spice is not particularly limited, and the content of the above-mentioned spice raw materials is preferably 0.000001 to 1% by mass relative to the total mass of the oral composition. The content of the flavoring spice using the above-mentioned spice raw materials is preferably 0.05 to 2% by mass relative to the total mass of the oral composition.

[0083] As active ingredients, for example, the following can be cited: bactericides such as isopropylmethylphenol and cetylpyridinium chloride; water-soluble phosphoric acid compounds such as potassium salts and sodium salts of orthophosphoric acid (excluding component (C) therein); enzymes such as dextranase, mutanase, amylase, and protease; tranexamic acid, ε-aminocaproic acid, triclosan, lysozyme chloride, hinokitiol, ascorbic acid, tocopheryl acetate, dihydrocholesterol, α-bisabolol, chlorhexidine salts, aluminum lactate, strontium chloride, potassium nitrate, berberine, hydroxamic acid or its derivatives, glycyrrhizic acid or its salts, glycyrrhetinic acid or its derivatives, dental calculus preventives. The above-mentioned active ingredients can be formulated in an effective amount within the range that does not interfere with the effects of the present invention.

[0084] Examples of pH adjusters include citric acid, tartaric acid, malic acid and their potassium and sodium salts, as well as sodium hydroxide.

[0085] The pH of the oral composition at 25°C is preferably 6.0 to 11.0, more preferably 6.0 to 8.5.

[0086] The pH of the oral composition in this instruction manual is the value measured using a pH meter (model: InLabRoutinePro-ISM) manufactured by METTLERTOLEDO at 25°C for 3 minutes.

[0087] [Form, Dosage Form] Oral compositions can be prepared in various forms, such as liquids, pastes, gels, and solids. That is, there are no particular limitations on the dosage form of oral compositions.

[0088] Oral formulations are typically oral preparations that are expelled from the oral cavity after use. Examples of oral preparations include, for instance, dental floss (liquid dental floss, liquid dental floss, toothpaste, wet powder dental floss, powdered dental floss, etc.), mouthwash, mouthwash, ointment, oral spray, adhesive, tablet, intraoral sustained-release preparation, chewing agent, intraoral dissolving agent, intraoral disintegrant, tongue care agent, oral cooling agent, and denture care agent.

[0089] The oral composition of this embodiment is suitable as a dental cleaning agent in the above-described dosage form, and is particularly suitable as a toothpaste.

[0090] [Manufacturing Method] The oral composition of this embodiment is manufactured by a known method. For example, it can be prepared by mixing component (A), component (B), component (C), and component (D), and other components as needed, using conventional methods.

[0091] As described above, the oral composition of the present invention, due to the inclusion of component (C), is able to prevent the deposition of dental calculus.

[0092] Furthermore, oral compositions exhibit an astringent sensation due to the presence of component (D).

[0093] Furthermore, since the oral composition contains components (A), (B), and (C), it can mitigate the effect of component (D) on the oral mucosa, and components (A) and (B) can prevent the synergistic effect of components (C) and (D) on the peeling of the oral mucosa.

[0094] Example The present invention will be described in detail below with reference to embodiments, but the present invention is not limited thereto.

[0095] Note that in the following examples, “%” as the unit of content represents “mass %” unless otherwise specified.

[0096] [Raw materials used] <Component (A)> · Sodium fluoride: Manufactured by Stella Chemifa Co., Ltd.

[0097] <Component (B)> · Calcium lactate hydrate: Manufactured by Taihei Chemical Industry Co., Ltd., trade name “Calcium lactate (Japanese: 乳酸カルシウム)”. Recorded as “Lactic acid Ca” in the table.

[0098] · Calcium gluconate: Manufactured by Fuso Chemical Industry Co., Ltd. Recorded as “Gluconic acid Ca” in the table.

[0099] · Calcium glycerophosphate: Manufactured by Iwaki Pharmaceutical Co., Ltd. Recorded as “Glycerophosphoric acid Ca” in the table.

[0100] · Calcium chloride: Manufactured by Tomita Pharmaceutical Co., Ltd. Recorded as “Chloride Ca” in the table.

[0101] · Calcium pantothenate: Manufactured by BASF. Recorded as “Pantothenic acid Ca” in the table.

[0102] <Component (C)> · Potassium pyrophosphate: Manufactured by Taihei Chemical Industry Co., Ltd. Recorded as “Pyrophosphate K” in the table.

[0103] · Sodium pyrophosphate: Manufactured by Taihei Chemical Industry Co., Ltd., product name “Sodium pyrophosphate (anhydrous) (Japanese: ピロリン酸ナトリウム(無水))”. Recorded as “Pyrophosphate Na” in the table.

[0104] · Sodium tripolyphosphate: Manufactured by Taihei Chemical Industry Co., Ltd. Recorded as “Tripolyphosphate Na” in the table.

[0105] <Component (D)> · Allantoin: Manufactured by Permachem Asia Co., Ltd..

[0106] · Sodium azulene sulfonate: Manufactured by Alps Pharmaceutical Ind. Co., Ltd.

[0107] · Sodium chloride: Manufactured by Nihon Suisankagaku Co., Ltd.

[0108] · Sodium copper chlorophyllin: Manufactured by TAMABIOCHEMICAL CO., LTD.

[0109] <Optional component> · Water: Purified water • Anhydrous silica (abrasive silica): Manufactured by Tamaki Chemical Co., Ltd.

[0110] • Sorbitol liquid (70%): Manufactured by Mitsubishi Corporation Food Tech Co., Ltd.

[0111] • Propylene glycol: Manufactured by Dow Chemical.

[0112] • Sodium saccharin: Manufactured by Daito Chemical Co., Ltd.

[0113] • Fragrance: Fragrance composition A (Tables 5-6).

[0114] [Examples 1-23, Comparative Examples 1-4] According to the composition shown in Tables 1 to 4, the ingredients were mixed, the pressure was reduced to 4 kPa and defoaming was performed to obtain 1.0 kg of toothpaste.

[0115] Empty columns in the table indicate that the ingredient was not used. The "balance" of purified water indicates the amount needed to make the total amount of the oral composition 100%.

[0116] The obtained oral compositions were evaluated as follows, and the results are shown in the table.

[0117] [Evaluation Method] Oral mucosal dissection Ten subjects used the oral composition according to the method of use described below, and the mucosal peeling in the oral cavity was immediately evaluated according to the scoring criteria described below. The average score of the ten subjects was calculated, and this average score was used according to the judgment criteria described below. Make a judgment.

[0118] How to Use Place 1g of the oral composition (teeth cleaner) on a toothbrush, brush your teeth for 3 minutes, spit it out, and rinse your mouth with 50mL of water.

[0119] Evaluation Criteria 4 points: No change in the mucosa.

[0120] 3 points: The mucous membrane feels irritated.

[0121] 2 points: The mucous membrane feels rough.

[0122] 1 point: Mucosal detachment occurs.

[0123] Judgment Criteria <Convergence> Ten subjects used the oral composition as described below, and the sensation of gingival tightness during use was evaluated according to the following scoring criteria. The average score of the ten subjects was calculated, and this average score was used according to the following judgment criteria. Make a judgment.

[0124] How to Use Place 1g of the oral composition (teeth cleaner) on a toothbrush, brush your teeth for 3 minutes, spit it out, and rinse your mouth with 50mL of water.

[0125] Evaluation Criteria 4 points: The gums feel very tight.

[0126] 3 points: The gums feel quite tight.

[0127] 2 points: Slightly tightness in the gums.

[0128] 1 point: There is almost no tightness in the gums.

[0129] Judgment Criteria [Table 1] [Table 2] [Table 3] [Table 4] As shown in the results above, the oral mucosal peeling of the oral compositions of Examples 1 to 23 was evaluated as “0” or “◎”, and the astringency was evaluated as “0” or “◎”.

[0130] The oral mucosal stripping of Comparative Examples 1 and 2, which lack component (A) or component (B), is evaluated as "×".

[0131] The evaluation of calculus deposition prevention in Comparative Example 3, which lacks component (C), is “×”.

[0132] The convergence of Comparative Example 4, which lacks the (D) component, is rated as "×".

[0133] The results above confirm that by applying the invention of this application, it is possible to prevent the deposition of dental calculus, provide a tightening sensation, and prevent the peeling of the oral mucosa.

[0134] (Formula example) The following are examples of formulations of oral compositions to which the present invention is applicable. In each example, the percentage indicating content is "mass %".

[0135] The following formulations 1-6 can also prevent the deposition of tartar, provide a tightening sensation, and prevent the peeling of the oral mucosa.

[0136] Furthermore, in the above formulation examples 1 to 6, flavoring compositions B to P as described in Tables 5 and 6 below were used instead of flavoring composition A. In addition, toothpaste, liquid dental cleaner or mouthwash with the same composition were prepared. As a result, they were able to prevent the deposition of tartar, provide an astringent sensation and prevent the peeling of the oral mucosa.

[0137] The compositions of fragrances 1-7 and solvents recorded in Tables 5 and 6 are shown in Tables 7-14.

[0138] It should be noted that "removing the fore-fraction a%" in the table refers to the initial a% when removing fractionated essential oils, and "removing the fore-fraction and the final b%" refers to the initial b% and the final b% when removing fractionated essential oils.

[0139] [Table 5] [Table 6] [Table 7] [Table 8] [Table 9] [Table 10] [Table 11] [Table 12] [Table 13] [Table 14]

Claims

1. An oral composition, characterized in that, Include: (A) Sodium fluoride; (B) Water-soluble calcium salts; (C) Selected from one or more condensed phosphoric acid and their alkali metal salts; and (D) Astringent.

2. The oral composition according to claim 1, wherein, The (D) component is selected from at least one of allantoin and its derivatives, azurite and its derivatives, water-soluble copper compounds, and sodium chloride.

3. The oral composition according to claim 2, wherein, The component (D) is selected from at least one of allantoin and its derivatives. The molar ratio of component (C) to component (D) is 0.03 to 14.

00.

4. The oral composition according to claim 2, wherein, The (D) component is selected from at least one of azurite and its derivatives and water-soluble copper compounds. The molar ratio of component (C) to component (D) is 1.00 to 3000.

5. The oral composition according to claim 2, wherein, The component (D) is sodium chloride. The molar ratio of component (C) to component (D) is 0.0004 to 0.

26.

6. The oral composition according to claim 1, wherein, The molar ratio of component (B) to component (A) is 0.03 to 10. The molar ratio of component (C) to component (A) is 0.005 to 1.

5.

7. The oral composition according to claim 1, wherein, Relative to the total mass of the oral composition, The content of component (A) is 0.09–1.3% by mass. The content of component (B) is 0.02–5.0% by mass. The content of component (C) is 0.02 to 3.0% by mass.

8. The oral composition according to claim 2, wherein, The (D) component is selected from one or more of allantoin, allantoin chlorohydroxyaluminum, allantoin aluminum, and dihydroxyallantoin aluminum. The content of component (D) is 0.01 to 0.5% of the total mass of the oral composition.

9. The oral composition according to claim 2, wherein, The (D) component is selected from at least one of azurite and its derivatives and water-soluble copper compounds. The content of component (D) is 0.001 to 0.15% of the total mass of the oral composition.

10. The oral composition according to claim 2, wherein, The component (D) is sodium chloride. The content of component (D) is 2.0 to 10.0% of the total mass of the oral composition.

11. The oral composition according to claim 1, wherein, The component (B) is selected from one or more of calcium chloride, calcium glycerophosphate, calcium gluconate, calcium lactate and calcium pantothenate.

12. The oral composition according to claim 1, wherein, The component (C) is selected from one or more of pyrophosphate, tripolyphosphate, tetrapolyphosphate, trimetaphosphate, tetraetaphosphate, hexametaphosphate, and their sodium and potassium salts.

13. The oral composition according to claim 2, wherein, The azurite and its derivatives are azurite and / or azurite sodium sulfonate hydrate.

14. The oral composition according to claim 2, wherein, The water-soluble copper compound is selected from one or more of sodium copper chlorophyllin, copper sulfate, and copper chloride.

15. The oral composition according to any one of claims 1 to 14, wherein, The oral composition is a dental cleaning agent.

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