Composition for relieving children eczema and application thereof
By using a specific ratio of egg yolk oil, Artemisia annua extract, phytosterol oleate, phytosterol compound, and ceramide NP, this product solves the problems of high irritation and poor antibacterial effect in the treatment of childhood eczema, achieving significant antibacterial effect, reducing skin damage and melanin deposition, and is suitable for children's skin care products.
Patent Information
- Application Number
- CN202511500761.8
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-10-21
- Publication Date
- 2025-12-19
AI Technical Summary
Existing products for treating childhood eczema are highly irritating to children's skin and have poor antibacterial effects, making it difficult to quickly relieve eczema symptoms, especially to inhibit melanin synthesis and reduce skin damage.
A composition for relieving childhood eczema is formed by combining egg yolk oil, Artemisia annua extract, phytosterol oleate, and phytosterols, with the addition of ceramide NP. Through synergistic effects in a specific ratio, the composition is prepared by heating, stirring, and filtering.
It significantly inhibits bacteria, reduces itching, reduces skin damage, inhibits melanin synthesis, and restores the skin to its original state. It is suitable for children's skin and has low irritation.
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Abstract
Description
Technical Field
[0001] This invention relates to the field of raw materials for children's skin care products, and in particular to a composition that can be used to soothe childhood eczema and its application. Background Technology
[0002] Eczema is a common skin disease in infancy, belonging to the category of allergic dermatitis. During an acute flare-up, the skin of affected children typically displays visible red rashes and edema. As the condition progresses, papules, vesicles, and large papules may appear. In severe cases, skin ulcers and sores may develop, with the center of the lesion worsening more rapidly and potentially spreading to surrounding areas. In the subacute phase, redness and swelling are reduced, oozing decreases, and ulcers form crusts. In the chronic phase, the skin thickens, pigmentation changes occur, and in severe cases, lichenification may develop. Because the typical symptom is intense itching, and children often have poor self-control, scratching can cause the eczema to spread. The itching can also severely affect sleep quality, and long-term eczema can negatively impact growth and development.
[0003] Currently, the treatment of eczema generally involves using strong bactericides or corticosteroids to kill the pathogens causing skin lesions, thereby alleviating eczema symptoms and relieving itching. However, children's skin is very sensitive and fragile because it is 20%-30% thinner than adult skin. The aforementioned bactericides are too irritating for children's skin. Although they can inhibit bacterial damage to the skin, these ingredients themselves can also harm children's skin. Therefore, milder ingredients are added to products for children. However, children's skin is more alkaline, resulting in a lower ability to inhibit bacteria. Existing milder antibacterial ingredients lack the acidic environment of adult skin, resulting in poor antibacterial effects and difficulty in quickly soothing children's eczema. Therefore, there is still room for improvement. Summary of the Invention
[0004] To quickly soothe childhood eczema with minimal skin irritation, this application provides a composition and its application for soothing childhood eczema. In a first aspect, this application provides a composition that can be used to soothe childhood eczema, employing the following technical solution: A composition for relieving childhood eczema, comprising the following components in parts by weight: Solvent 20-40 parts; Moisturizer 22.03-48.1 parts; Skin conditioning agent 0.05-0.2 parts; The emollient is a compound of egg yolk oil, Artemisia annua extract, phytosterol oleate, and phytosterols.
[0005] By adopting the above technical solution, and using egg yolk oil, Artemisia annua extract, phytosterol oleate, and phytosterols in combination, the synergistic effect of each component can achieve a very significant antibacterial effect, effectively inhibit hyaluronidase, and significantly inhibit melanin synthesis. This makes it less likely for dark spots to remain after eczema heals, and less likely to affect the appearance of the skin. In addition, the composition has low irritation and is less likely to cause secondary damage to children's skin. It is well-suited for relieving the condition of children's eczema and well meets the needs of consumers.
[0006] Preferably, in the emollient, the mass ratio of egg yolk oil, Artemisia annua extract, phytosterol oleate, and phytosterols is 20-40:1-5:1-3:0.03-0.1.
[0007] By adopting the above technical solution and by specifically selecting the mass ratio of egg yolk oil, Artemisia annua extract, phytosterol oleate, and phytosterols, the components are combined in a specific ratio to exert a more significant synergistic effect, resulting in better antibacterial, soothing, and melanin-reducing effects at the healing site.
[0008] Preferably, the skin conditioning agent is ceramide NP.
[0009] By adopting the above technical solution and adding ceramide NP, the soothing effect can be further improved, and it can help promote skin barrier repair, thus making the effect of relieving childhood eczema better.
[0010] Preferably, the solvent is caprylic / capric triglyceride.
[0011] By adopting the above technical solution and specifically selecting caprylic / capric triglyceride as the solvent, each component has high solubility in the solvent, thereby enabling each component to exert a better synergistic effect and providing better relief for childhood eczema.
[0012] Preferably, the Artemisia annua extract is an oil-soluble extract.
[0013] By adopting the above technical solution, and by specifically selecting Artemisia annua extract as an oil-soluble extract, the special active ingredients in the oil-soluble extract can work together with other ingredients in the emollient to exert a significant synergistic effect, thereby achieving a significant effect in relieving childhood eczema.
[0014] Secondly, this application provides a method for preparing a composition that can be used to soothe childhood eczema, using the following technical solution: A method for preparing the above-mentioned composition for relieving childhood eczema includes the following steps: Step 1), heat and stir the solvent, emollient, and skin conditioner until they are mixed evenly to obtain a premix; Step 2), filter the premix to obtain a composition that can be used to soothe childhood eczema.
[0015] By adopting the above technical solution, the composition prepared for relieving childhood eczema can significantly relieve skin discomfort during childhood eczema, reduce itching, reduce secondary skin damage caused by children scratching, inhibit bacteria, reduce skin damage caused by bacterial infection, and reduce melanin deposition in the skin after healing, so that the skin can return to its original state. It has low irritation and is very suitable for children.
[0016] Preferably, in step 1), the heating temperature is 60-80℃, the stirring speed is 15-30 r / min, and the stirring time is 5-10 min.
[0017] By adopting the above technical solution and mixing at 60-80℃, the active ingredients can better cooperate with each other, thereby exerting a significant synergistic effect.
[0018] Preferably, in step 2), the premix is cooled to 45°C or below before filtration.
[0019] By adopting the above technical solution, cooling and then filtering reduces the excessive contact between the composition and air at high temperatures, resulting in better product quality.
[0020] Thirdly, this application provides an application of a composition that can be used to soothe childhood eczema, employing the following technical solution: An application of the above-mentioned composition for relieving childhood eczema, wherein the composition for relieving childhood eczema is added to a skin care product formulation to prepare a skin care product with the effect of relieving childhood eczema, wherein the composition for relieving childhood eczema has a mass content of 1-10% in the skin care product.
[0021] By adopting the above technical solution, the composition that can be used to soothe childhood eczema can be applied to skin care products, which can make the skin care products have a significant effect in soothing childhood eczema, with low irritation, and can protect the skin well, allowing the skin to recover to its original state.
[0022] In summary, this application has the following beneficial effects: 1. Because this application uses egg yolk oil, Artemisia annua extract, phytosterol oleate, and phytosterols in combination, the synergistic effect of each component can achieve a very significant antibacterial effect, effectively inhibit hyaluronidase, and significantly inhibit melanin synthesis. This makes it less likely to leave dark spots after eczema heals and less likely to affect the appearance of the skin. In addition, the composition has low irritation and is less likely to cause secondary damage to children's skin. It is well-suited for relieving the condition of children's eczema and well meets the needs of consumers.
[0023] 2. In this application, the preferred method is to select the specific mass ratio of egg yolk oil, Artemisia annua extract, phytosterol oleate, and phytosterols so that the components are combined in a specific ratio to exert a more significant synergistic effect, resulting in better antibacterial, soothing, and melanin-reducing effects at the healing site.
[0024] 3. In this application, the addition of ceramide NP is preferred, which can further enhance the soothing effect and help promote skin barrier repair, thus making the effect of relieving childhood eczema better. Detailed Implementation
[0025] The present application will be further described in detail below with reference to the embodiments. Example 1
[0026] A composition for relieving childhood eczema, prepared by the following steps: Step 1): Add 20 kg of caprylic / capric triglycerides, 20 kg of egg yolk oil, 1 kg of Artemisia annua extract, 1 kg of phytosterol oleate, 0.03 kg of phytosterols, and 0.05 kg of ceramide NP into a mixing vessel, purge with nitrogen to remove air, heat to 60°C under a sealed environment, stir at 15 r / min for 5 min until homogeneous, and obtain a premix.
[0027] Step 2), cool the premix to 45°C, filter and discharge to obtain a composition that can be used to soothe childhood eczema.
[0028] Caprylic / capric triglycerides were purchased from Wilmar Oils & Fats Biotechnology Co., Ltd.
[0029] Egg yolk oil was purchased from Guangzhou Junmu Biotechnology Co., Ltd.
[0030] Artemisia annua extract was purchased from Guangdong Gexin Biotechnology Co., Ltd., and is an oil-soluble extract.
[0031] Phytosterol oleate was purchased from Guangzhou Youran Biotechnology Co., Ltd.
[0032] Phytosterols were purchased from Guangzhou Youran Biotechnology Co., Ltd.
[0033] Ceramide NP was purchased from Guangzhou Baihaobo Biotechnology Co., Ltd. Example 2
[0034] A composition for relieving childhood eczema, prepared by the following steps: Step 1): Add 30 kg of caprylic / capric triglyceride, 30 kg of egg yolk oil, 3 kg of Artemisia annua extract, 2 kg of phytosterol oleate, 0.06 kg of phytosterols, and 0.1 kg of ceramide NP into a mixing vessel, purge with nitrogen to remove air, heat to 70°C under a sealed environment, stir at 25 r / min for 8 min until homogeneous, and obtain a premix.
[0035] Step 2), cool the premix to 45°C, filter and discharge to obtain a composition that can be used to soothe childhood eczema.
[0036] Caprylic / capric triglycerides were purchased from Wilmar Oils & Fats Biotechnology Co., Ltd.
[0037] Egg yolk oil was purchased from Guangzhou Junmu Biotechnology Co., Ltd.
[0038] Artemisia annua extract was purchased from Guangdong Gexin Biotechnology Co., Ltd., and is an oil-soluble extract.
[0039] Phytosterol oleate was purchased from Guangzhou Youran Biotechnology Co., Ltd.
[0040] Phytosterols were purchased from Guangzhou Youran Biotechnology Co., Ltd.
[0041] Ceramide NP was purchased from Guangzhou Baihaobo Biotechnology Co., Ltd. Example 3
[0042] A composition for relieving childhood eczema, prepared by the following steps: Step 1): Add 40 kg of caprylic / capric triglyceride, 40 kg of egg yolk oil, 5 kg of Artemisia annua extract, 3 kg of phytosterol oleate, 0.1 kg of phytosterols, and 0.2 kg of ceramide NP into a mixing vessel, purge with nitrogen to remove air, heat to 80°C under a sealed environment, stir at 30 r / min for 10 min until homogeneous, and obtain a premix.
[0043] Step 2), cool the premix to 45°C, filter and discharge to obtain a composition that can be used to soothe childhood eczema.
[0044] Caprylic / capric triglycerides were purchased from Wilmar Oils & Fats Biotechnology Co., Ltd.
[0045] Egg yolk oil was purchased from Guangzhou Junmu Biotechnology Co., Ltd.
[0046] Artemisia annua extract was purchased from Guangdong Gexin Biotechnology Co., Ltd., and is an oil-soluble extract.
[0047] Phytosterol oleate was purchased from Guangzhou Youran Biotechnology Co., Ltd.
[0048] Phytosterols were purchased from Guangzhou Youran Biotechnology Co., Ltd.
[0049] Ceramide NP was purchased from Guangzhou Baihaobo Biotechnology Co., Ltd.
[0050] Comparative Example 1 A composition that can be used to soothe childhood eczema, differing from Example 2 only in that: Replace the egg yolk oil with an equal amount of camellia oil.
[0051] Camellia oil was purchased from Guangzhou Minghui Fine Chemical Co., Ltd.
[0052] Comparative Example 2 A composition that can be used to soothe childhood eczema, differing from Example 2 only in that: Artemisia argyi extract was used to replace Artemisia annua extract in an equal amount.
[0053] Artemisia argyi extract was purchased from Zhuanzhou Zhanhong Biotechnology Co., Ltd.
[0054] Comparative Example 3 A composition that can be used to soothe childhood eczema, differing from Example 2 only in that: Bisabolol was used to replace phytosterol oleate in equal amounts.
[0055] Bisabolol was purchased from Guangzhou Youcui Biotechnology Co., Ltd.
[0056] Comparative Example 4 A composition that can be used to soothe childhood eczema, differing from Example 2 only in that: Cholesterol was used to replace phytosterols in equal amounts.
[0057] Cholesterol was purchased from Guangzhou Youcui Biotechnology Co., Ltd.
[0058] Comparative Example 5 A composition that can be used to soothe childhood eczema, differing from Example 2 only in that: Camellia oil was used to replace egg yolk oil in equal amounts, Artemisia argyi extract was used to replace Artemisia annua extract in equal amounts, bisabolol was used to replace phytosterol oleate in equal amounts, and cholesterol was used to replace phytosterols in equal amounts.
[0059] Camellia oil was purchased from Guangzhou Minghui Fine Chemical Co., Ltd.
[0060] Artemisia argyi extract was purchased from Zhuanzhou Zhanhong Biotechnology Co., Ltd.
[0061] Bisabolol was purchased from Guangzhou Youcui Biotechnology Co., Ltd.
[0062] Cholesterol was purchased from Guangzhou Youcui Biotechnology Co., Ltd.
[0063] Experiment 1 According to WS / T 650-2019 "Evaluation Methods for Antibacterial and Bacteriostatic Effects" 5.1.1, the suspension quantitative antibacterial test was used to detect the inhibition rate of the test samples prepared from the compositions of each example and comparative example that can be used to relieve childhood eczema against Staphylococcus aureus (ATCC6538).
[0064] Test sample: Take 1g of the composition that can be used to soothe childhood eczema and 99g of caprylic / capric triglycerides, mix them evenly to obtain the test sample.
[0065] Experiment 2 The hyaluronidase inhibition rate (%) of the test samples prepared from the compositions of each embodiment and comparative example that can be used to soothe childhood eczema was determined according to T / JSRH 003-2023 "Test of anti-allergic activity of cosmetic raw materials - hyaluronidase inhibition method".
[0066] Test sample: Take 1g of the composition that can be used to soothe childhood eczema and 99g of caprylic / capric triglycerides, mix them evenly to obtain the test sample.
[0067] Experiment 3 According to T / GDCA 006—2021 "Test Method for Inhibition of Tyrosinase Activity by Cosmetic Raw Materials (In Vitro Method)", the tyrosinase inhibition rate (%) of the test samples prepared from the compositions of each embodiment and comparative example that can be used to soothe childhood eczema was tested.
[0068] Test sample: Take 1g of the composition that can be used to soothe childhood eczema and 99g of caprylic / capric triglycerides, mix them evenly to obtain the test sample.
[0069] Experiment 4 Irritation scores (IS) of test samples prepared from compositions for relieving childhood eczema in each example and comparative example were tested according to SNT 2329-2009, "Eye Irritation / Corrosivity of Cosmetics - Chicken Embryo Villi Allantoic Membrane Test".
[0070] IS < 1: Non-irritating.
[0071] 1 ≤ IS < 5: Mild irritation.
[0072] 5 ≤ IS < 9: Moderate irritation.
[0073] IS≥10: Strong irritant / corrosive.
[0074] Test sample: Take 1g of the composition that can be used to soothe childhood eczema and 99g of caprylic / capric triglycerides, mix them evenly to obtain the test sample.
[0075] Detailed experimental data for each experiment are shown in Table 1.
[0076] Table 1
[0077] According to the data comparison of each embodiment and comparative example in Table 1, the antibacterial rate (%), hyaluronidase inhibition rate (%), and tyrosinase inhibition rate (%) of each embodiment are significantly higher than those of each comparative example. It can be seen that each embodiment has a better antibacterial effect, which can reduce the bacterial infection of eczema skin, significantly inhibit skin itching, reduce children's scratching, thereby reducing secondary skin damage, and significantly inhibit melanin synthesis, so that after the eczema subsides, the skin is less likely to leave dark spots, and the skin can recover well.
[0078] In each comparative example, other ingredients with antibacterial and soothing effects were used to replace egg yolk oil, artemisia annua extract, phytosterol oleate, and phytosterols in the examples, either individually or in whole. Although the comparative examples also had lower irritation and could be used on children's skin, the examples had even lower irritation and were more skin-friendly for children. However, the antibacterial and soothing effects of the comparative examples were not as good as those of the examples, and the skin protection effect was not as good. Furthermore, the effect of the comparative examples in inhibiting melanin was significantly lower than that of the examples, making it difficult to reduce melanin deposition after the eczema heals, which led to the formation of dark spots on the skin. It can be seen that only when egg yolk oil, artemisia annua extract, phytosterol oleate, and phytosterols are combined in a specific ratio can significant antibacterial, soothing, and melanin deposition reduction effects be achieved with lower irritation.
[0079] This specific embodiment is merely an explanation of this application and is not intended to limit it. After reading this specification, those skilled in the art can make modifications to this embodiment without contributing any inventive step, but such modifications are protected by patent law as long as they fall within the scope of the claims of this application.
Claims
1. A composition for relieving childhood eczema, characterized in that: The components include the following parts by mass: Solvent 20-40 parts; Moisturizer 22.03-48.1 parts; Skin conditioning agent 0.05-0.2 parts; The emollient is a compound of egg yolk oil, Artemisia annua extract, phytosterol oleate, and phytosterols.
2. The composition according to claim 1 for relieving childhood eczema, characterized in that: In the emollient, the mass ratio of egg yolk oil, Artemisia annua extract, phytosterol oleate, and phytosterols is 20-40:1-5:1-3:0.03-0.
1.
3. The composition according to claim 2 for relieving childhood eczema, characterized in that: The skin conditioning agent is ceramide NP.
4. The composition according to claim 3 for relieving childhood eczema, characterized in that: The solvent is caprylic / capric triglyceride.
5. A composition according to claim 1 for relieving childhood eczema, characterized in that: The Artemisia annua extract is an oil-soluble extract.
6. A method for preparing a composition according to any one of claims 1-5 that can be used to soothe childhood eczema, characterized in that: Includes the following steps: Step 1), heat and stir the solvent, emollient, and skin conditioner until they are mixed evenly to obtain a premix; Step 2), filter the premix to obtain a composition that can be used to soothe childhood eczema.
7. A method for preparing a composition for relieving childhood eczema according to claim 6, characterized in that: In step 1), the heating temperature is 60-80℃, the stirring speed is 15-30 r / min, and the stirring time is 5-10 min.
8. A method for preparing a composition for relieving childhood eczema according to claim 7, characterized in that: In step 2), the premix is cooled to 45°C or below before filtration.
9. The application of a composition according to any one of claims 1-5 for relieving childhood eczema, characterized in that: The composition that can be used to soothe childhood eczema is added to a skin care product formulation to prepare a skin care product with the effect of soothing childhood eczema, wherein the composition that can be used to soothe childhood eczema has a mass content of 1-10% in the skin care product.